CN214334445U

CN214334445U - Whole blood filtering module

Info

Publication number: CN214334445U
Application number: CN202120353731.XU
Authority: CN
Inventors: 许行尚; 杰弗瑞·陈
Original assignee: Nanjing Lanyu Biological Technology Co Ltd
Current assignee: Nanjing Lanyu Biological Technology Co Ltd
Priority date: 2021-02-08
Filing date: 2021-02-08
Publication date: 2021-10-01
Anticipated expiration: 2031-02-08

Abstract

The utility model discloses a whole blood filtration module, which comprises a chip sampling channel, a chip pressurizing structure, a chip filtration bin and a chip shifting hand component, wherein the chip pressurizing structure is arranged above the chip filtration bin, the chip sampling channel is arranged at one side of the chip pressurizing structure, and the chip shifting hand component is arranged below the chip filtration bin; the chip shifting hand component shifts the whole blood filter chip to the chip filter bin, and the whole blood sample to be detected is filtered in the whole blood filter chip by introducing air through the chip pressurizing structure to pressurize. The sampling needle sucks the filtered plasma/serum for sampling, and then the sampled plasma/serum sample is added into the detection card of the turntable module. The whole blood filtering module is matched with other modules to operate efficiently and smoothly, so that the automatic sample adding machine can realize high-flux detection, and the reagent card strip and the microfluidic chip can perform detection; and meanwhile, the sample adding detection of the whole blood sample is realized, and the detection efficiency is high.

Description

Whole blood filtering module

Technical Field

The utility model belongs to the technical field of medical equipment, especially, relate to a whole blood filter module suitable for automatic model machine that adds.

Background

The fluorescent immunological technique (immunofluoresence technique) is the first one of the development in the labeling immunological technique. It is a technology established on the basis of immunology, biochemistry and microscope technology. The technology is mainly characterized in that: strong specificity, high sensitivity and high speed.

The basic principle is as follows: a new immunoassay technology using fluorescein labeled antibody or antigen as tracer, the principle is similar to ELISA. The method can be used for quantifying the antigen and the antibody in the liquid, and can also be used for qualitatively and quantitatively quantifying the antigen and the antibody in the tissue section. Generally, the self-fluorescence of the sample and the reagent and the scattering of the exciting light cause high background fluorescence, which affects the sensitivity of the measurement. Lanthanide is generally used as a fluorescent label (tracer). After the tracer is combined with corresponding antigen or antibody, the fluorescence phenomenon is observed or the fluorescence intensity is measured by means of a fluorescence detector, so that the existence, location and distribution condition of the antigen or antibody can be judged or the content of the antigen or antibody in a detected sample can be detected.

The existing disease diagnosis process generally comprises the steps of adding a sample into a sample inlet of a reagent card strip after sample treatment, and then manually putting the reagent card strip into a detection analyzer for detection. The reagent card strip can not be added after the sample is automatically diluted and uniformly mixed, and the sample further automatically enters a detection analyzer for detection.

Chinese patent document (application number: 201820280185.X) discloses a sample injection device and a system. The sample feeding device comprises a first driving mechanism, a second driving mechanism and a turntable. Through a actuating mechanism drive carousel rotation, place at the storage tank carousel when the reagent pipe and rotate, when the reagent pipe is placed in the storage tank, just can realize rotating and advance the appearance. With this sampling device and sampling needle cooperation use, this kind of mode of rotating to advance a kind makes things convenient for the sampling needle to take a sample more for the straight line sampling mode among the prior art to the structure is compacter. Further, each accommodating groove is driven to rotate by the second driving mechanism, so that the reagent tube placed in the accommodating groove can be driven to rotate, and then samples in the reagent tube can be uniformly mixed. The sample introduction device adopts a reagent tube on the turntable for sample introduction each time, can not continuously introduce samples, and can only detect reagent clamping strips.

Therefore, there is a need to develop a whole blood filtration module suitable for a full-automatic sample adding machine, which is matched with other modules to operate efficiently and smoothly, so that the automatic sample adding machine can realize high-throughput detection, and both a reagent card strip and a microfluidic chip can perform detection; and meanwhile, the sample adding detection of the whole blood sample is realized, and the detection efficiency is high.

SUMMERY OF THE UTILITY MODEL

The technical problem to be solved by the utility model is to provide a whole blood filtering module suitable for a full-automatic sample adding machine, the whole blood filtering module is matched with other modules to operate efficiently and smoothly, so that the automatic sample adding machine can realize high-flux detection, and a reagent clamping strip and a micro-fluidic chip can perform detection; and meanwhile, the sample adding detection of the whole blood sample is realized, and the detection efficiency is high.

In order to solve the technical problem, the whole blood filtering module comprises a chip sampling channel, a chip pressurizing structure, a chip filtering bin and a chip shifting hand assembly, wherein the chip pressurizing structure is arranged above the chip filtering bin, the chip sampling channel is arranged on one side of the chip pressurizing structure, and the chip shifting hand assembly is arranged below the chip filtering bin; the chip shifting hand component shifts the whole blood filtering chip to the chip filtering bin, and the chip pressurizing structure is filled with air to pressurize, so that a whole blood sample to be detected is filtered in the whole blood filtering chip. The sampling needle sucks the filtered plasma/serum for sampling, and then the sampled plasma/serum sample is added into the detection card of the turntable module.

As a preferred technical solution of the present invention, the chip hand-shifting assembly comprises a chip hand-shifting and a chip hand-shifting motion assembly, the chip hand-shifting motion assembly drives the chip hand-shifting to move, so that the chip hand-shifting shifts the whole blood filtering chip to move; chip group's hand motion subassembly includes chip group's hand motion motor, chip group's hand belt, chip group's hand action wheel, chip group's hand from driving wheel, chip group's hand slide rail and chip group's hand belt coupling assembling, chip group's hand motion motor with chip group's hand action wheel is connected, chip group's hand action wheel through chip group's hand belt with chip group's hand is connected from the driving wheel, be equipped with chip group's hand belt coupling assembling on the chip group's hand belt, chip group's hand belt coupling assembling connects chip group's hand slider and chip group's hand, chip group's hand motion motor passes through chip group's hand belt drives chip group's hand is dialled the slider through the chip and is dialled the motion of hand slide rail along the chip.

As a preferred technical solution of the present invention, the whole blood filtration module further comprises a chip bin, the chip bin is disposed at one end of the chip filtration bin, the chip bin comprises a casing, a whole blood filtration chip storage tank is disposed in the casing, a chip support structure is disposed at the bottom of the casing, and a spacer is disposed below one side of the casing; the whole blood filter chip is placed on the chip support structure. Through the spacer when whole blood filter chip dials out, the effect of spacer is when moving the process of getting whole blood filter chip and putting into whole blood filter module from the chip storehouse, prevents that the whole blood filter chip in the inside in chip storehouse from spilling.

As the utility model discloses an optimal technical scheme, this whole blood filtration module still includes chip abandonment passageway, the chip abandonment passageway is established the bottom in chip filtration storehouse, the sampling is accomplished the back, whole blood filters the chip and passes through the chip hand setting subassembly drives and reachs the chip abandonment passageway, thereby pass through the chip abandonment passageway gets into abandonment groove.

As the utility model discloses an it is preferred technical scheme, whole blood filters the chip and includes whole blood sample chamber and filter chamber, the chip pressurization structure lets the whole blood sample that awaits measuring follow after letting in air pressurization whole blood sample chamber gets into in the filter chamber to accomplish the filtration of the whole blood sample that awaits measuring. The whole blood sample cavity is pressurized by introducing air through the chip pressurizing structure, so that the whole blood sample enters the filter cavity after being filtered by the whole blood filtering chip, and the sample of the second sampling module is sucked and sampled aiming at the plasma/serum in the filter cavity and is added into the detection card of the turntable module.

As the utility model discloses an optimal technical scheme, chip abandonment passageway includes chip abandonment passageway one and chip abandonment passageway two, chip abandonment passageway one with chip abandonment passageway two the initiating terminal of chip abandonment passageway one is established the chip exit in chip filtration storehouse just chip abandonment passageway sets up with the horizontal direction slope downwards chip abandonment passageway two sets up with the horizontal direction slope, the initiating terminal of chip abandonment passageway two is established one side of the end of chip abandonment passageway one just chip abandonment passageway sets up towards abandonment groove and horizontal direction slope two-way down, thereby makes chip abandonment passageway two can accept the follow the abandonment that chip abandonment passageway one came out whole blood filters the chip and passes through chip abandonment passageway two gets into the waste gas groove. After the whole blood filter chip samples, the chip is dialled the hand and is stirred whole blood filter chip and reachs abandonment position, accepts through the cooperation of chip abandonment passageway one and chip abandonment passageway two and accepts and makes during waste whole blood filter chip gets into abandonment groove.

Compared with the prior art, the utility model discloses the beneficial effect who has is: the whole blood filtering module is matched with other modules to operate efficiently and smoothly, so that the automatic sample adding machine can realize high-flux detection, and the reagent card strip and the microfluidic chip can perform detection; and meanwhile, the sample adding detection of the whole blood sample is realized, and the detection efficiency is high.

Drawings

The following is a more detailed description of embodiments of the present invention with reference to the accompanying drawings:

FIG. 1 is a block diagram of a whole blood filtration module of the present invention;

FIG. 2 is a block diagram of a chip chamber in the whole blood filtration module of the present invention;

FIG. 3 is a structural diagram of a chip hand-shifting movement assembly in the whole blood filtration module of the present invention;

FIG. 4 is a partially enlarged structural view of a chip paddle motion assembly in the whole blood filtration module of the present invention;

FIG. 5 is a structural diagram of a whole blood filter chip in the whole blood filter module according to the present invention;

wherein: 1-whole blood filtration module; 101-chip sampling channel; 102-a chip pressurization structure; 103-a chip filtration bin; 104-chip finger; 105-whole blood filter chip; 1051-whole blood sample chamber; 1052-a filter chamber; 106-chip paddle motion component; 1061-chip hand-pulling motion motor; 1062-chip hand-pulling belt; 1063-chip hand-dialing driving wheel; 1064-chip hand-pulling driven wheel; 1065-chip handle slide; 1066-chip handle strap connection assembly; 1067-chip hand-dialing slider; 107-chip bins; 1071-case; 1072 — chip support structure; 1073-spacer; 1074-handle; 108-chip waste channel; 1081-chip discard channel one; 1082-chip discard channel two.

Detailed Description

To better explain the technical solution of the present invention, the technical solution of the present invention will now be described in further detail with reference to the accompanying drawings and examples.

Example (b): as shown in fig. 1-5, the whole blood filtration module 1 includes a chip sampling channel 101, a chip pressurizing structure 102, a chip filtration chamber 103, and a chip handle assembly, wherein the chip pressurizing structure 102 is disposed above the chip filtration chamber 103, the chip sampling channel 101 is disposed on one side of the chip pressurizing structure 102, and the chip handle assembly is disposed below the chip filtration chamber 103; the chip shifting hand component shifts the whole blood filtering chip 105 to the chip filtering bin 103, the chip pressurizing structure 102 is filled with air to pressurize, so that a whole blood sample to be detected is filtered in the whole blood filtering chip 105, a sampling needle absorbs filtered plasma/serum to sample, and the collected plasma/serum sample is added into a detection card of the turntable module.

3-4, the chip hand-dialing component comprises a chip hand-dialing 104 and a chip hand-dialing motion component 106, and the chip hand-dialing motion component 106 drives the chip hand-dialing 104 to move, so that the chip hand-dialing 104 dials the whole blood filtering chip 105 to move; the chip hand-dialing motion assembly 106 comprises a chip hand-dialing motion motor 1061, a chip hand-dialing belt 1062, a chip hand-dialing driving wheel 1063, a chip hand-dialing driven wheel 1064, a chip hand-dialing slide rail 1065 and a chip hand-dialing belt connecting assembly 1066, wherein the chip hand-dialing motion motor 1061 is connected with the chip hand-dialing driving wheel 1063, the chip hand-dialing driving wheel 1063 is connected with the chip hand-dialing driven wheel 1064 through a chip hand-dialing belt 1062, the chip hand-dialing belt 1062 is provided with a chip hand-dialing belt connecting assembly 1066, the chip hand-dialing belt connecting assembly 1066 is connected with a chip hand-dialing slider 1067 and a chip hand 104, the chip hand-dialing slider 1067 is connected with a chip hand-dialing slide rail 1065, the chip hand-dialing motion motor 1061 is started to drive the chip hand-dialing driving wheel 1063 to rotate, the chip hand-dialing driving wheel 1063 drives the chip hand-dialing driven wheel 1064 to rotate through the chip hand-dialing belt 1062, thereby drive chip group handle belt coupling assembling 1066 motion, chip group handle belt coupling assembling 1066 drives chip group handle 104 and passes through chip group handle slider 1067 moves along chip group handle slide rail 1065.

As shown in fig. 2, the whole blood filtration module 1 further comprises a chip bin 107, the chip bin 107 is arranged at one end of the chip filtration bin 103, the chip bin 107 comprises a housing 1071, a whole blood filtration chip storage slot is arranged in the housing 1071, and a plurality of whole blood filtration chips 105 are stacked in the whole blood filtration chip storage slot; a chip supporting structure 1072 is arranged at the bottom of the shell 1071, and a spacer 1073 is arranged below one side of the shell 1071; the whole blood filtering chip 105 is placed on the chip supporting structure 1072, and the chip hand-pulling component pulls the whole blood filtering chip 105 into the chip filtering bin 103 through the spacer 1073 for whole blood filtering; the chip bin 107 further comprises a handle 1074, wherein the handle 1074 is arranged on one side of the shell 1071, so that the chip bin 1071 can be taken out conveniently; the whole blood filtering module 1 further comprises a chip waste channel 108, wherein the chip waste channel 108 is arranged at the bottom of the chip filtering bin 103, and after sampling is finished, the whole blood filtering chip 105 is driven by the chip handle assembly to reach the chip waste channel 108, so as to enter a waste groove through the chip waste channel 108; the chip waste channel 108 comprises a first chip waste channel 1081 and a second chip waste channel 1082, the starting end of the first chip waste channel 1081 and the second chip waste channel 1082 are arranged at the chip outlet of the chip filter bin 103, the first chip waste channel 1081 is inclined downwards towards the second chip waste channel 1082 and the horizontal direction, the starting end of the second chip waste channel 1082 is arranged at one side of the tail end of the first chip waste channel 1081, and the second chip waste channel 1082 is inclined downwards towards the waste groove and the horizontal direction, so that the second chip waste channel 1082 can receive the waste whole blood filter chips 105 coming out of the first chip waste channel 1081 and enter the waste gas groove through the second chip waste channel 1082; after the whole blood filtering chip 105 is sampled, the chip handle 104 pulls the whole blood filtering chip 105 to reach the waste position, and the waste whole blood filtering chip 105 enters the waste groove through the matching of the chip waste channel I1081 and the chip waste channel II 1082.

As shown in fig. 5, the whole blood filter chip 105 includes a whole blood sample chamber 1051 and a filter chamber 1052, and the chip pressurizing structure 102 is pressurized by introducing air to make the whole blood sample to be tested enter the filter chamber 1052 from the whole blood sample chamber 1051, thereby completing the filtration of the whole blood sample to be tested; the whole blood sample chamber 1051 is pressurized by introducing air through the chip pressurizing structure 102, so that the whole blood sample enters the filter chamber 1052 after being filtered by the whole blood filtering chip 105, and the sample of the second sampling module is sucked and sampled aiming at the plasma/serum in the filter chamber and is added into the detection card of the turntable module.

The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the above embodiments, and that the foregoing embodiments and descriptions are provided only to illustrate the principles of the present invention without departing from the spirit and scope of the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A whole blood filtration module is characterized by comprising a chip sampling channel, a chip pressurizing structure, a chip filtration bin and a chip shifting hand assembly, wherein the chip pressurizing structure is arranged above the chip filtration bin, the chip sampling channel is arranged on one side of the chip pressurizing structure, and the chip shifting hand assembly is arranged below the chip filtration bin; the chip shifting hand component shifts the whole blood filtering chip to the chip filtering bin, and the chip pressurizing structure is filled with air to pressurize, so that a whole blood sample to be detected is filtered in the whole blood filtering chip.

2. The whole blood filtration module of claim 1, wherein the chip paddle assembly comprises a chip paddle and a chip paddle motion assembly, the chip paddle motion assembly driving the chip paddle to move, thereby causing the chip paddle to paddle the whole blood filtration chip to move; chip group's hand motion subassembly includes chip group's hand motion motor, chip group's hand belt, chip group's hand action wheel, chip group's hand from driving wheel, chip group's hand slide rail and chip group's hand belt coupling assembling, chip group's hand motion motor with chip group's hand action wheel is connected, chip group's hand action wheel through chip group's hand belt with chip group's hand is connected from the driving wheel, be equipped with chip group's hand belt coupling assembling on the chip group's hand belt, chip group's hand belt coupling assembling connects chip group's hand slider and chip group's hand, chip group's hand motion motor passes through chip group's hand belt drives the chip group's hand passes through chip group's hand slider is followed chip group's hand slide rail motion.

3. The whole blood filtration module according to claim 1, further comprising a chip compartment, wherein the chip compartment is disposed at one end of the chip filtration compartment, the chip compartment comprises a housing, a whole blood filtration chip storage tank is disposed in the housing, a chip support structure is disposed at the bottom of the housing, and a spacer is disposed below one side of the housing; the whole blood filter chip is placed on the chip support structure.

4. The whole blood filtration module according to claim 1, further comprising a chip waste channel, wherein the chip waste channel is arranged at the bottom of the chip filtration bin, and after sampling is completed, the whole blood filtration chip is driven by the chip handle assembly to reach the chip waste channel, so as to enter a waste groove through the chip waste channel.

5. The whole blood filtration module according to claim 1, wherein the whole blood filtration chip comprises a whole blood sample chamber and a filter chamber, and the chip pressurization structure is pressurized by introducing air to allow the whole blood sample to be tested to enter the filter chamber from the whole blood sample chamber, so as to complete the filtration of the whole blood sample to be tested.

6. The whole blood filtration module according to claim 4, wherein the chip waste channel comprises a first chip waste channel and a second chip waste channel, the starting ends of the first chip waste channel and the second chip waste channel are arranged at the chip outlet of the chip filtration bin, the chip waste channel is arranged downwards and slantwise towards the second chip waste channel and the horizontal direction, the starting end of the second chip waste channel is arranged at one side of the tail end of the first chip waste channel, and the chip waste channel is arranged downwards and slantwise towards the waste groove and the horizontal direction, so that the second chip waste channel can receive the waste whole blood filtration chip coming out of the first chip waste channel and enter the waste gas groove through the second chip waste channel.