CN214081075U - Locking device and micro-fluidic biochemical analyzer - Google Patents

Abstract

The utility model relates to the technical field of medical equipment, specifically disclose a locking device and micro-fluidic biochemical analyzer, the locking device includes driving piece, apical axis and the retaining member that is used for compressing tightly the chip carrier, the driving piece has the motion axle that can follow vertical direction reciprocating motion, the apical axis sets up in the tip of motion axle, the retaining member rotationally overlaps and locates the apical axis, the retaining member can be under self action of gravity with the apical axis along vertical direction butt, when needing to lock the chip carrier, the driving piece drives the retaining member to move to and chip carrier butt, then the driving piece drives the apical axis and continues relative retaining member motion to separate, the retaining member can rotate along with the magnetism piece is synchronous, and the rotation of retaining member can not be interfered by driving piece and apical axis; when the chip carrier is unlocked, the moving shaft of the driving piece moves upwards, and the locking piece is driven by the jacking shaft to be separated from the chip carrier, so that the chip carrier can be automatically locked without manual operation.

Description

Locking device and micro-fluidic biochemical analyzer

Technical Field

The utility model relates to the technical field of medical equipment, especially, relate to a locking device and micro-fluidic biochemical analysis appearance.

Background

Biochemical analysis is one of the important means commonly used in clinical diagnosis, and various biochemical indexes are determined by analyzing blood or other body fluids. Microfluidics refers to the technology of processing or manipulating tiny fluids using microchannels, involving chemical, fluid physics, microelectronics, new materials, biology, biomedical engineering, and the like. Because of the miniaturization, integration, and other features, microfluidic devices are often referred to as microfluidic chips. Biochemical analyzers, also commonly referred to as biochemics, are instruments that use the principle of optoelectric colorimetry to measure a particular chemical component in a body fluid. Because of its fast measuring speed, high accuracy and small reagent consumption, it is widely used in hospitals, epidemic prevention stations and family planning service stations.

In the portable full-automatic biochemical analyzer disclosed in the prior art, the chip is driven by the holding part to enter and exit the inside of the housing, and is locked by the locking device, and then is driven to rotate by the rotation driving part. The locking device comprises a rotary tray which is arranged on the holding part and used for supporting the chip and a locking disc used for locking the chip, wherein the chip is pressed on the locking tray by the locking disc. However, the locking disc needs to be manually fixed on the rotating tray by a person, so that the testing efficiency is low.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a: the utility model provides a locking device and micro-fluidic biochemical analysis appearance to solve portable full-automatic biochemical analysis device among the correlation technique when locking the chip, need the manual work to install locking disc to locking tray with chip position locking, problem that efficiency of software testing is low.

In one aspect, the present invention provides a locking device comprising a driving member, a top shaft and a locking member for pressing a chip carrier;

the driving piece is provided with a moving shaft capable of reciprocating along the vertical direction, and the top shaft is arranged at the end part of the moving shaft;

the retaining member is rotationally overlapped and is located the apical axis, the retaining member can under self action of gravity with the apical axis is along vertical direction butt, just when the retaining member compresses tightly the chip carrier, the motion axle can drive the apical axis is relative the retaining member motion, so that the apical axis with the retaining member is along vertical direction separation.

As a preferable technical scheme of the locking device, the locking member is provided with a matching hole, the top shaft is rotatably inserted into the matching hole, and the top shaft can slide in the vertical direction relative to the hole wall of the matching hole.

As a preferable technical scheme of the locking device, the matching hole comprises a first matching hole and a second matching hole which are communicated, the aperture of the first matching hole is matched with the outer diameter of the top shaft, and the aperture of the second matching hole is larger than the outer diameter of the top shaft;

the top shaft can slide between the first matching hole and the second matching hole relative to the locking piece, and when the locking piece is abutted against the top shaft along the vertical direction under the action of self gravity, the top shaft is positioned in the first matching hole; when the top shaft is separated from the locking piece along the vertical direction, the top shaft is positioned in the second matching hole.

As the preferred technical scheme of locking device, the retaining member includes the pressure disk and set up in the piece is inhaled to the pressure disk, the mating holes set up in the pressure disk, the chip carrier has the fixed orifices, and works as the pressure disk butt in when the chip carrier, inhale the piece peg graft in the fixed orifices.

As a preferred technical solution of the locking device, the locking device further includes a first anti-slip pad, the first anti-slip pad is disposed on the lower end surface of the pressure plate, and the pressure plate can press the first anti-slip pad against the chip carrier.

As a preferable technical scheme of the locking device, the suction block is partially inserted into the second matching hole, the suction block is provided with a pressing surface located in the second matching hole, and the top shaft can be abutted to or separated from the pressing surface.

As a preferable technical scheme of the locking device, a conical transition surface is arranged between the first matching hole and the second matching hole.

As a preferable technical scheme of the locking device, the jacking shaft is in threaded connection with the moving shaft.

As a preferred technical solution of the locking device, the locking member has a locking position for pressing the chip carrier and an unlocking position separated from the chip carrier, and the driving member can drive the locking member to move between the locking position and the unlocking position;

the locking device also comprises a first sensor and a second sensor, and an induction sheet is fixed on the moving shaft; when the first sensor is matched with the sensing piece, the locking piece is positioned at the locking position; when the second sensor is matched with the sensing piece, the locking piece is located at the unlocking position.

In another aspect, the present invention provides a microfluidic biochemical analyzer, including the locking device according to any of the above schemes.

The utility model has the advantages that:

the utility model provides a hold-down device and micro-fluidic biochemical analyzer, this hold-down device includes the driving piece, the apical axis and be used for compressing tightly the retaining member of chip carrier, the driving piece has the motion axle that can follow vertical direction reciprocating motion, the apical axis sets up in the tip of motion axle, the retaining member rotationally overlaps and locates the apical axis, the retaining member can be under self action of gravity with the apical axis along vertical direction butt, when needing to lock the chip carrier, the driving piece drives the retaining member to move to and chip carrier butt, then the driving piece drives the apical axis and continues relative retaining member motion to separation, the retaining member can rotate along with the magnetism piece is synchronous, and driving piece and apical axis can not interfere the rotation of retaining member; when the chip carrier is unlocked, the moving shaft of the driving piece moves upwards, and the locking piece is driven by the jacking shaft to be separated from the chip carrier, so that the chip carrier can be automatically locked without manual operation.

Drawings

FIG. 1 is an exploded view of a microfluidic biochemical analyzer according to an embodiment of the present invention;

FIG. 2 is an exploded view of a part of the structure of the micro-fluidic biochemical analyzer according to the embodiment of the present invention;

fig. 3 is a first cross-sectional view of the microfluidic biochemical analyzer (with the compressing member in the unlocked position) according to an embodiment of the present invention;

fig. 4 is a second cross-sectional view of the microfluidic biochemical analyzer according to an embodiment of the present invention (the pressing member is in the locking position, and the top shaft abuts against the suction block);

fig. 5 is a third cross-sectional view of the microfluidic biochemical analyzer according to the embodiment of the present invention (the pressing member is in the locking position, and the top shaft is separated from the pressing plate);

fig. 6 is a cross-sectional view of a pressing device in an embodiment of the present invention;

FIG. 7 is an exploded view of a hold-down device in an embodiment of the invention;

FIG. 8 is an exploded view of a rotary drive assembly according to an embodiment of the present invention;

fig. 9 is a cross-sectional view of a rotary drive and a tray in an embodiment of the invention;

FIG. 10 is an exploded view of a chip carrier according to an embodiment of the present invention;

fig. 11 is a first cross-sectional view of a chip carrier according to an embodiment of the present invention;

fig. 12 is a second cross-sectional view of the chip carrier according to the embodiment of the present invention;

fig. 13 is an exploded view of a chip carrier according to an embodiment of the present invention;

FIG. 14 is a schematic structural view of a boat in an embodiment of the present invention;

fig. 15 is a schematic structural diagram of a key in an embodiment of the present invention;

fig. 16 is a schematic structural view of a push rod in an embodiment of the present invention;

FIG. 17 is an exploded view of a test chip according to an embodiment of the present invention;

fig. 18 is a schematic structural diagram of a test chip according to an embodiment of the present invention.

In the figure:

1. a warehouse in and out device; 11. a main body support; 111. a test bin; 12. a tray; 121. a first plate; 122. a second plate; 123. a third plate; 124. a channel groove; 125. fixing the round hole; 126. a stopper; 127. a first detection hole; 128. a second detection hole; 13. a gear; 14. a rack; 15. a warehouse in and out motor; 16. a motor fixing plate; 17. a first photosensor; 18. a second photosensor;

2. a rotation driving device; 21. a main motor; 22. a support disc; 221. a guide slope; 222. a first groove; 223. a second groove; 224. a convex column; 225. positioning holes; 226. a conical surface; 23. a magnetic member; 24. mounting a plate; 25. a second non-slip mat; 26. an encoder;

3. a chip carrier; 31. a carrying tray; 311. a fixing hole; 312. a first guide surface; 313. avoiding vacant positions; 314. a key hole; 315. a push rod groove; 316. a chute; 317. a second limiting surface; 32. a cover plate; 33. pressing a key; 331. a key guide surface; 332. a jack; 34. a first elastic member; 35. a push rod; 351. a sliding part; 352. a plug-in part; 353. a head portion; 36. a second elastic member;

4. a locking device; 41. a locking member; 411. sucking blocks; 412. a platen; 413. a first mating hole; 414. a second mating hole; 415. a first mating surface; 416. a compression surface; 417. inserting a column; 42. a drive member; 421. a motion shaft; 43. a top shaft; 431. a second mating surface; 44. locking the bracket; 45. a first sensor; 46. an induction sheet; 47. a second sensor; 48. a first non-slip mat;

5. testing the chip; 51. a chip body; 511. fixing grooves; 512. a baffle plate; 513. a slide rail; 514. a first limiting surface; 515. a sample application channel; 5151. a sample adding slot; 5152. a sample application cavity; 5153. capillary pores; 5154. a waste fluid chamber; 516. a detection chamber; 52. reagent tablets; 53. an upper sealing film; 531. a sample application hole; 54. a lower sealing film; 541. a detection hole; 542. an exhaust hole; 55. an identification code;

61. a first light source module; 62. a second light source module; 63. a code scanner;

71. an upper heating body; 72. a lower heating body; 73. a temperature sensor.

Detailed Description

The technical solution of the present invention will be described clearly and completely with reference to the accompanying drawings, and obviously, the described embodiments are some, but not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention. And the embodiments described below by referring to the drawings are exemplary only for explaining the present invention, and should not be construed as limiting the present invention.

Referring to fig. 1 to 18, the present embodiment provides a microfluidic biochemical analyzer, which includes a supporting plate 22, a magnetic member 23, a chip carrier 3 and a locking device 4. The magnetic member 23 is arranged on the supporting plate 22, the chip carrier 3 is used for placing the test chip 5 and is provided with a fixing hole 311, at least one test chip 5 is arranged on the chip carrier 3, and the chip carrier 3 is supported on the supporting plate 22; the locking device 4 comprises a locking member 41, the locking member 41 can be inserted into the fixing hole 311 and magnetically attracted with the magnetic member 23, and the locking member 41 can press the chip carrier 3 against the supporting plate 22. It is understood that the locking member 41 includes at least a magnetic or magnetically attractable member, and the magnetic member 23 may be an electromagnet or a magnet. In the microfluidic biochemical analyzer provided by the embodiment, the locking member 41 is magnetically attracted to the magnetic member 23 disposed on the supporting plate 22 to fix the chip carrier 3 on the supporting plate 22, so that the locking structure is simple and the cost is low.

The micro-fluidic biochemical analyzer further comprises a rotary driving device 2, the rotary driving device 2 comprises a main motor 21, a supporting plate 22 is in transmission connection with the main motor 21, and after the rotary driving device 2 and a locking device 4 lock a test chip 5 on a chip carrier 3, the rotary driving device 2 drives the test chip 5 to rotate so as to test the test chip 5.

The microfluidic biochemical analyzer also comprises an inlet and outlet device 1 and a detection component. The warehouse-in and warehouse-out device 1 comprises a main body support 11 and a tray 12, wherein the main body support 11 is provided with a test warehouse 111, the tray 12 is movably arranged on the main body support 11, and the tray 12 can slide relative to the main body support 11 and is provided with a test position and a sample adding position. Specifically, the main motor 21 is disposed on the main body support 11, the supporting plate 22 is disposed on the moving path of the tray 12, the supporting plate 22 is provided with a guiding inclined plane 221, the chip carrier 3 includes a carrier plate 31 having a fixing hole 311, at least one test chip 5 is disposed on the carrier plate 31, and when the tray 12 is located at the sample loading position, the carrier plate 31 is supported on the tray 12 and can move with the tray 12; in the process that the tray 12 is switched from the sample adding position to the testing position, the carrier plate 31 can abut against the guide inclined surface 221 and move along the guide inclined surface 221; when the tray 12 is located at the testing position, the carrier plate 31 is completely separated from the tray 12 and supported on the supporting plate 22, and the magnetic members 23 are opposite to the fixing holes 311. When the tray 12 is at the testing position, the locking member 41 can be inserted into the fixing hole 311 and magnetically attracted to the magnetic member 23 and the locking member 41 presses the tray 31 against the supporting plate 22. The detection assembly comprises a first light source module 61, and the first light source module 61 is used for emitting detection light to the detection position of the test chip 5 and collecting the detection light reflected by the detection position. This micro-fluidic biochemical analyzer adopts test chip 5 to detect the body fluid, and the body fluid can directly be loaded in test chip 5, need not to set up application of sample system and cleaning system alone, and simple structure, the cost is lower, can effectively save the space and occupy and convenient to carry. When the tray 12 carries the carrier 31 and moves from the sample loading position to the testing position, the guiding slope 221 disposed on the supporting tray 22 guides one end of the carrier 31 to be lifted from the tray 12 and move along the guiding slope 221, along with the movement of the tray 12, the carrier 31 is finally separated from the tray 12 and moves to the supporting tray 22, then the carrier 31 can be fixed on the supporting tray 22 through the locking member 41, and the main motor 21 can drive the supporting tray 22 to drive the carrier 31 to rotate, so as to test the testing chip 5. The micro-fluidic biochemical analyzer realizes the transfer of the carrying disc 31 from the tray 12 to the supporting disc 22 through a mechanical structure, has a simple structure, is favorable for further reducing the cost, and is favorable for further reducing the whole volume. It will be appreciated that during the transfer of the boat 31 from the tray 12 to the support tray 22, the boat 31 is raised to a set height, which can be set as desired.

Optionally, referring to fig. 1 and fig. 2, the tray 12 includes a U-shaped channel 124, the channel 124 is surrounded by a first plate 121, a second plate 122 and a third plate 123, wherein the first plate 121 and the second plate 122 are disposed in parallel and at an interval, the third plate 123 is connected between the first plate 121 and the second plate 122, and the channel 124 extends along the moving direction of the tray 12. In this embodiment, the lower surface of the third plate 123 is higher than the upper surface of the supporting plate 22, and the supporting plate 22 will be located below the channel groove 124 during the process of moving the tray 12 from the loading position to the testing position. The third plate 123 is provided with a fixing circular hole 125, the diameter of the fixing circular hole 125 is greater than the width of the third plate 123, and the fixing circular hole 125 is arranged in the middle along the width direction of the third plate 123, so that the carrier disc 31 can be placed in the fixing circular hole 125 and then supported on the first plate 121 and the second plate 122, at this time, the lower surface of the carrier disc 31 is lower than the height of the upper edge of the guide inclined plane 221 and higher than the height of the lower surface of the third plate 123, so that when the carrier disc 31 is driven by the tray 12 to move, the carrier disc 31 can abut against the guide inclined plane 221 and be separated from the tray 12 under the guide of the guide inclined plane 221.

Optionally, referring to fig. 1 and fig. 2, the device 1 further includes a first stopping member and a second stopping member, one of the first stopping member and the second stopping member is disposed on the main body bracket 11, and the other of the first stopping member and the second stopping member is disposed on the tray 12, when the tray 12 is located at the sample adding position, the tray 12 is located outside the test chamber 111, and the first stopping member and the second stopping member are separated; the first and second stops cooperate to prevent the tray 12 from passing beyond the testing position when the tray 12 is in the testing position. In this way, the first stop member and the second stop member can ensure that the tray 12 is accurately stopped at the testing position. In this embodiment, the first stop member is a first photoelectric sensor 17, the second stop member is a first detection hole 127, when the tray 12 is located at the test position, the first photoelectric sensor 17 is matched with the first detection hole 127, and when the tray 12 is separated from the test position, the first photoelectric sensor 17 is separated from the first detection hole 127. Specifically, the first detection hole 127 may be disposed on the first plate 121 or the second plate 122, in this embodiment, the first detection hole 127 is disposed on the first plate 121, the first photosensor 17 is fixed on the main body bracket 11, the first photosensor 17 includes an integrally disposed light emitting end and a light receiving end, when the tray 12 is located at the test position, the first detection hole 127 can just move to a position opposite to the first photosensor 17, at this time, light emitted from the light emitting end of the first photosensor 17 can penetrate through the first detection hole 127, so that the light receiving end of the first photosensor 17 cannot receive reflected light, and the first photosensor 17 emits a high level (or a low level) indicating that the tray 12 is located at the test position at this time; when the tray 12 is out of the testing position, the light emitted from the light emitting end of the first photosensor 17 is reflected by the first plate 121 and received by the light receiving end of the first photosensor 17, and the first photosensor 17 emits a low level (or a high level) indicating that the tray 12 is out of the testing position. When the first photoelectric sensor 17 is matched with the first detection hole 127, the controller collects a signal of the first photoelectric sensor 17 and controls the in-out motor 15 to stop working so as to stop the tray 12 at the test position. In other embodiments, the first and second stop members may also be two flat surfaces of the main body bracket 11 and the tray 12 that can abut against each other.

Optionally, referring to fig. 1 and fig. 2, in order to ensure that the tray 12 can be effectively limited to the carrier plate 31, a plurality of stoppers 126 are disposed on each of the first plate 121 and the second plate 122, the stoppers 126 extend along the circumferential direction of the fixing circular holes 125, and the stoppers 126 can abut against the test chips 5 fixed on the carrier plate 31.

Optionally, referring to fig. 1 and fig. 2, the in-out device 1 further includes a driving component, and the driving component drives the tray 12 to switch between the sample loading position and the testing position. In this embodiment, the driving assembly includes a rack 14 disposed on the tray 12, a gear 13 engaged with the rack 14, and a motor 15 connected to the gear 13 for driving the tray 12 to slide on the main body support 11. The arrangement is such that the tray 12 can be driven by the in-out motor 15 to automatically enter and exit the test chamber 111. Specifically, the in-out motor 15 is fixed to the main body bracket 11 through the motor fixing plate 16, the gear 13 is located in the test chamber 111, and the rack 14 is fixed to the first plate 121 or the second plate 122, which is beneficial to reducing the space occupation. In other embodiments, the driving assembly may also be configured as a driving motor and belt transmission assembly, or as a pneumatic cylinder, etc.

Optionally, referring to fig. 1 and fig. 2, the device for taking in and out of a cartridge 1 further includes a third stopping member and a fourth stopping member, and when the tray 12 is located at the sample loading position, the third stopping member and the fourth stopping member are matched; when the tray 12 is in the test position, the third and fourth stops are separated. In this embodiment, the third stopping member is a second photoelectric sensor 18, the fourth stopping member is a second detection hole 128, when the tray 12 is located at the sample-adding position, the second photoelectric sensor 18 is matched with the second detection hole 128, and when the tray 12 is separated from the sample-adding position, the second photoelectric sensor 18 is separated from the second detection hole 128. Through the cooperation of the second photoelectric sensor 18 and the second detection hole 128, it can be ensured that the tray 12 is accurately stopped at the sample application position when the tray 12 is moved from the test position to the sample application position. Specifically, in the present embodiment, the second detection hole 128 is provided on the first plate 121, and the second photosensor 18 is fixed to the main body frame 11. The working principle of the second photoelectric sensor 18 and the second detection hole 128 is the same as that of the first photoelectric sensor 17 and the first detection hole 127, and the description thereof is omitted. In other embodiments, the third and fourth stops may also be two flat surfaces that can abut against each other on the main body bracket 11 and the tray 12.

Optionally, referring to fig. 1 and fig. 2, the microfluidic biochemical analyzer further includes a heating device for heating the test chamber 111. Specifically, the heating device includes an upper heating body 71, and the upper heating body 71 is connected to the main body support 11 and can seal the test chamber 111 of the main body support 11. Preferably, the heating device further comprises a lower heating body 72, and the lower heating body 72 is disposed in the test chamber 111 and fixed to the main body support 11. When the tray 12 is located at the test position, the boat 31 is located between the upper heating body 71 and the lower heating body 72, and the test chip 5 can be heated by the upper heating body 71 and the lower heating body 72. It is further preferred that the heating device further comprises a temperature sensor 73, and the temperature sensor 73 is used for detecting the temperature in the test chamber 111 to prevent the heating temperature from being too high. Further preferably, two temperature sensors 73 are arranged, the two temperature sensors 73 are respectively used for detecting the temperatures of the upper heating body 71 and the lower heating body 72, the upper heating body 71 and the lower heating body 72 are electrified for heating, the real-time temperatures of the two heating bodies are detected by the two temperature sensors 73, when the required temperature is reached, the heating of the upper heating body 71 and the heating of the lower heating body 72 are stopped, if the temperature is reduced, the upper heating body 71 and the lower heating body 72 are electrified for heating, and the process is circulated so as to ensure that the temperature in the test bin 111 always keeps the required test temperature, so that the influence of the ambient temperature on the test process and the test result is eliminated.

Optionally, referring to fig. 3 to 7, the locking device 4 further includes a driving member 42 and a top shaft 43. The driving member 42 has a moving shaft 421 capable of reciprocating along the vertical direction, the top shaft 43 is disposed at the end of the moving shaft 421, the locking member 41 is rotatably sleeved on the top shaft 43, the locking member 41 can abut against the top shaft 43 along the vertical direction under the action of self gravity, and when the locking member 41 presses the carrying tray 31 of the chip carrier 3, the moving shaft 421 can drive the top shaft 43 to move relative to the locking member 41, so that the top shaft 43 is separated from the locking member 41 along the vertical direction. When the chip carrier 3 needs to be locked, the driving member 42 drives the locking member 41 to move to abut against the carrying tray 31 of the chip carrier 3, then the moving shaft 421 of the driving member 42 continues to move downwards relative to the locking member 41 until the top shaft 43 is separated from the locking member 41, at this time, the locking member 41 and the magnetic member 23 are magnetically attracted to fix the carrying tray 31, and further fix the chip 5, the locking member 41 can synchronously rotate along with the magnetic member 23 under the driving of the main motor 21 to test the chip 5, and the driving member 42 and the top shaft 43 cannot cause interference on the detection of the chip 5. When the chip carrier 3 needs to be unlocked, the moving shaft 421 of the driving member 42 moves upward, and after the moving shaft 421 drives the top shaft 43 to abut against the locking member 41, the top shaft 43 and the locking member 41 move synchronously, so that the locking member 41 moves to a position separated from the tray 31. With such an arrangement, manual operation can be avoided, and automatic locking of the chip carrier 3 can be realized by driving the locking member 41 to move through the driving member 42. In other embodiments, the top shaft 43 may be replaced by a suction cup or a pneumatic gripper, etc., and the selective connection of the driving member 42 to the locking member 41 may be achieved as well.

In this embodiment, the locking member 41 has a locking position pressed against the chip carrier 3 and an unlocking position separated from the chip carrier 3, the driving member 42 can drive the locking member 41 to move between the locking position and the unlocking position, when the locking member 41 is located at the unlocking position, the locking member 41 is inserted into the fixing hole 311 and magnetically attracted with the magnetic member 23 to fix the carrying tray 31 and the supporting tray 22 together, the moving shaft 421 can drive the top shaft 43 to move relative to the locking member 41, so that the top shaft 43 is separated from the locking member 41 in the vertical direction, the connection between the driving member 42 and the locking member 41 is disconnected, and the main motor 21 can drive the carrying tray 31 and the locking member 41 to synchronously rotate so as to detect the test chip 5.

Optionally, referring to fig. 3 to 7, the locking member 41 has a mating hole, the top shaft 43 is rotatably inserted into the mating hole, and the top shaft 43 can slide in a vertical direction relative to a hole wall of the mating hole. Specifically, the matching holes comprise a first matching hole 413 and a second matching hole 414 which are communicated and coaxially arranged, the aperture of the first matching hole 413 is matched with the outer diameter of the top shaft 43, and the aperture of the second matching hole 414 is larger than the outer diameter of the top shaft 43; the top shaft 43 can slide between the first matching hole 413 and the second matching hole 414 relative to the locking piece 41, and when the locking piece 41 abuts against the top shaft 43 under the action of self gravity along the vertical direction, the top shaft 43 is positioned in the first matching hole 413; when the top shaft 43 is vertically separated from the locker 41, the top shaft 43 is positioned at the second coupling hole 414. In this embodiment, the inner wall of the first engaging hole 413 has a first engaging surface 415, the top shaft 43 has a second engaging surface 431, and the first engaging surface 415 and the second engaging surface 431 can abut against each other in the vertical direction. It should be noted that, the structure of the fitting hole is not limited in this embodiment, and in other embodiments, the fitting hole may also be a hole with a uniform outer diameter, and the outer diameter of the fitting hole is matched with the outer diameter of the top shaft 43.

It should be noted that in the present embodiment, the shape of the second fitting hole 414 is similar to the shape of the first fitting hole 413, and the shapes of the first fitting hole 413 and the second fitting hole 414 are similar to the outer contour of the top shaft 43. The top shaft 43 can slide in the first engaging hole 413, so that the top shaft 43 and the locking member 41 are coaxial in the process of releasing the locking of the tray 31, and the locking member 41 and the moving shaft 421 are coaxial to prevent the locking member 41 from swinging freely. The second engagement hole 414 is loosely engaged with the top shaft 43 to ensure that the top shaft 43 is disengaged from the locking member 41 when the top shaft 43 is positioned in the second engagement hole 414. The driver 42 may be an electric push rod, and in other embodiments, the driver 42 may instead be an air cylinder. Preferably, a tapered transition surface is provided between the first mating hole 413 and the second mating hole 414. The transition surface guides the top shaft 43 smoothly from the second fitting hole 414 to the first fitting hole 413.

Alternatively, referring to fig. 3 to 7, the locking member 41 includes a pressing plate 412 and a suction block 411 disposed on the pressing plate 412, the pressing plate 412 and the supporting plate 22 are respectively disposed on two sides of the chip carrier 3, and the engaging holes are disposed on the pressing plate 412. Specifically, the driving member 42 can drive the pressure plate 412 and the suction block 411 to move through the top shaft 43, when the driving member 42 drives the suction block 411 to be inserted into the fixing hole 311 and the suction block 411 is attracted to the magnetic member 23, under the magnetic attraction of the suction block 411 and the magnetic member 23, the pressure plate 412 is pressed against the upper end surface of the load plate 31 to fix the load plate 31 on the supporting plate 22, and when the driving member 42 continues to move downward, the top shaft 43 is located in the second engaging hole 414, at this time, the driving member 42 is separated from the pressure plate 412, so that when the main motor 21 drives the supporting plate 22 to drive the load plate 31 to rotate, the suction block 411 and the pressure plate 412 can synchronously rotate along with the rotation, but the top shaft 43 does not cause interference.

Optionally, referring to fig. 3 to 7, the suction block 411 is inserted into the second matching hole 414, and the suction block 411 has a pressing surface 416 located in the second matching hole 414, in order to ensure that the locking member 41 is stably located at the locking position, when the tray 12 is located at the testing position, after the driving member 42 drives the suction block 411 to be inserted into the fixing hole 311, the driving member 42 drives the top shaft 43 to continue to move downward until the top shaft 43 abuts against the pressing surface 416, and then the driving member 42 drives the top shaft 43 to be separated from the pressing surface 416 and located in the second matching hole 414, and the top shaft 43 abuts against the suction block 411, so as to ensure that the position of the suction block 411 is accurate. In this embodiment, the actuating member 42 further includes a locking bracket 44, the locking bracket 44 is configured to be fixedly connected to the main body bracket 11, and the locking bracket 44 is configured to support the actuating member 42.

Optionally, referring to fig. 1 and fig. 2, the locking device 4 further includes a first sensor 45, a sensing piece 46 is fixed on the moving shaft 421, the sensing piece 46 can be engaged with or separated from the first sensor 45 during the extension and contraction of the moving shaft 421, when the first sensor 45 is engaged with the moving shaft 421, the top shaft 43 abuts against the pressing surface 416, and at this time, the locking member 41 is located at the locking position, which indicates that the attraction block 411 has been stably attracted to the magnetic member 23.

Optionally, referring to fig. 1 and 2, the locking device 4 further includes a second sensor 47, the sensing piece 46 can be engaged with or disengaged from the second sensor 47 during the process of extending and retracting the moving shaft 421, when the second sensor 47 is engaged with the moving shaft 421, the locking member 41 is located outside the fixing hole 311, and the locking member 41 is located at the unlocking position, which indicates that the boat 31 has been completely unlocked.

Alternatively, referring to fig. 3 to 4 and fig. 12, in order to ensure that the suction block 411 is smoothly inserted into the fixing hole 311, the upper edge of the fixing hole 311 is provided with a first guide surface 312, and the first guide surface 312 is in a bell shape and is used for guiding the suction block 411 to be inserted into the fixing hole 311.

Optionally, referring to fig. 7, in order to ensure the pressing effect on the carrier plate 31, the locking device 4 further includes a first anti-slip pad 48, the first anti-slip pad 48 is sleeved on the suction block 411 and abuts against the lower end surface of the pressure plate 412, and the pressure plate 412 can press the first anti-slip pad 48 against the upper end surface of the chip carrier 3, so as to ensure that when the main motor 21 rotates, a sufficient friction force can be provided to the chip carrier 3 through the pressure plate 412 to pull the chip carrier 3 to rotate synchronously, thereby preventing the chip carrier 3 and the pressure plate 412 from moving relatively.

Alternatively, referring to fig. 8 and 9, the rotation driving device 2 further includes a mounting plate 24, the main motor 21 is mounted to the mounting plate 24, and the mounting plate 24 is mounted to the main body support 11. Preferably, the rotation driving device 2 further includes a second anti-slip pad 25, the top surface of the supporting plate 22 is provided with a first groove 222, the second anti-slip pad 25 is embedded in the first groove 222, and when the tray 12 is located at the testing position, the carrying tray 31 is supported on the second anti-slip pad 25, when the locking member 41 is located at the locking position, under the suction effect of the suction block 411 and the magnetic member 23, the pressing plate 412 presses the carrying tray 31 against the second anti-slip pad 25, so that when the supporting plate 22 rotates, a sufficient friction force can be given to the carrying tray 31 by the second anti-slip pad 25 to ensure that the carrying tray 31 rotates synchronously with the supporting plate 22. It is understood that when the total weight of the chip carrier 3 and the test chip 5 thereon is greater than the predetermined weight, the second anti-slip pad 25 is not required, and the supporting plate 22 can give the carrying plate 31 enough friction force and drive it to rotate under the predetermined weight. In this embodiment, the first light source module 61 is mounted on the mounting plate 24.

Optionally, referring to fig. 8, a second groove 223 communicated with the first groove 222 is further disposed on the supporting plate 22, and the magnetic member 23 is embedded in the second groove 223. Preferably, the magnetic member 23 is annular, the second groove 223 is an annular groove, a protruding pillar 224 is convexly disposed on the bottom wall of the second groove 223, the second anti-slip pad 25 can be sleeved on the protruding pillar 224, a positioning hole 225 is disposed on the protruding pillar 224, and a center line of the positioning hole 225 coincides with a center line of the supporting plate 22. The sucking block 411 is provided with a plug column 417, and when the locking member 41 is located at the locking position, the plug column 417 is inserted into the positioning hole 225, so as to ensure that the plug column 417 and the supporting plate 22 are coaxial. Preferably, the opening end of the positioning hole 225 is provided with a tapered surface 226, the tapered surface 226 is in a bell mouth shape, and the inner diameter of the tapered surface 226 gradually decreases along the direction that the insertion column 417 is inserted into the positioning hole 225, so as to guide the insertion column 417 of the suction block 411 to be inserted into the positioning hole 225, so as to ensure that the insertion column 417 and the positioning hole 225 can be smoothly inserted.

Optionally, referring to fig. 2 to 4 and fig. 13, the carrier disc 31 is provided with a plurality of mounting locations at intervals, at least one mounting location is provided with the test chip 5, the plurality of mounting locations are uniformly distributed in the circumferential direction of the carrier disc 31, and an avoidance space 313 is provided between two adjacent mounting locations; the detection assembly further comprises a second light source module 62, the second light source module 62 and the first light source module 61 are oppositely arranged on two sides of the in-out device 1, and the second light source module 62 is used for collecting detection light emitted by the first light source module 61; when the tray 12 is located at the testing position and the locking member 41 is located at the locking position, the carrying tray 31 rotates to drive the detection position and the clearance position 313 of the testing chip 5 to pass between the first light source module 61 and the second light source module 62. Specifically, when the tray 12 is located at the testing position and the locking member 41 is located at the locking position, the microfluidic biochemical analyzer enters the testing state, the main motor 21 is started, and the carrier disc 31 is driven to rotate for a circle by the supporting disc 22, at this time, when the clearance 313 passes through the first light source module 61, the light emitted by the first light source module 61 is received by the second light source module 62 through the clearance 313, and the signal value received by the second light source module 62 can be used as a white bottom position. Preferably, the main motor 21 is further provided with an encoder 26, and when the second light source module 62 receives the detection light emitted by the first light source module 61, the encoder 26 records its position as an initial position. It should be noted that the first light source module 61 and the second light source module 62 are prior art, and the structure thereof is not described herein again.

The utility model discloses the scheme that is equipped with six installation positions on the year dish 31 has been given exemplarily, in other embodiments, also can set up the installation position on the year dish 31 as required into other figure, and this embodiment does not limit to this. In this embodiment, a maximum of six identical or different test chips 5 can be mounted on the carrier 31 for detection, and the detection efficiency is high. When the test chip 5 is mounted on the carrier disc 31, the test chip 5 exceeds the outer peripheral surface of the carrier disc 31, which helps to reduce the volume of the carrier disc 31, thereby facilitating the reduction of the overall volume of the microfluidic biochemical analyzer. The clearance hole 313 is located between two adjacent test chips 5.

Alternatively, referring to FIG. 17, the test chip 5 has an identification code 55, and the detecting assembly further includes a scanner 63, the scanner 63 being configured to scan the identification code 55 when the tray 12 is in the testing position and the retaining member 41 is in the locking position. The identification code 55 records data information of the test chips 5, when the microfluidic biochemical analyzer enters a test state, the main motor 21 is started, the carrier disc 31 is driven by the support disc 22 to rotate for a circle, the data information of each test chip 5 can be identified by the code scanner 63, and the position of each test chip 5 can be recorded by matching with the encoder 26.

Alternatively, referring to fig. 17, the test chip 5 includes a chip main body 51, a reagent sheet 52, an upper sealing film 53 and a lower sealing film 54. The chip main body 51 is provided with a sample adding channel 515 and a detection cavity 516, the reagent sheet 52 is fixed in the detection cavity 516, the upper sealing film 53 and the lower sealing film 54 are respectively arranged on the upper surface and the lower surface of the chip main body 51 and seal the sample adding channel 515, the upper sealing film 53 is provided with a sample adding hole 531, the sample adding hole 531 is communicated with the sample adding channel 515, and the sample adding channel 515 is communicated with the detection cavity 516, so that body fluid is added from the sample adding hole 531, and the body fluid can flow into the detection cavity 516 through the sample adding channel 515 and can react with the reagent sheet 52. Specifically, the sample addition channel 515 includes a sample addition groove 5151 corresponding to the sample addition hole 531, a sample addition chamber 5152 communicating with the sample addition groove 5151, a capillary 5153 communicating with the sample addition chamber 5152, and a waste liquid chamber 5154 communicating with the sample addition chamber 5152. The capillary aperture 5153 is in communication with the detection chamber 516.

Referring to fig. 18, in the embodiment, the lower sealing film 54 further has a detection through hole 541, the detection through hole 541 corresponds to a detection position of the reagent sheet 52, when the tray 12 is located at the detection position and the locking member 41 is located at the locking position, the main motor 21 drives the carrier plate 31 to rotate, the detection through hole 541 can pass through the upper side of the first light source module 61, the light emitted by the first light source module 61 irradiates the detection through hole 541, the reagent sheet 52 absorbs a portion of the light and can reflect another portion of the light to be received by the first light source module 61, and various indexes and parameters of the sample-added body fluid can be analyzed based on the light signal received by the first light source module 61.

Optionally, referring to fig. 18, the lower sealing film 54 is further provided with a vent hole 542 to prevent the sample feeding channel 515 from being blocked.

Optionally, referring to fig. 10 to 13, the chip carrier 3 further includes a plurality of fixing elements, the fixing elements are disposed corresponding to the mounting positions one by one, the fixing elements are disposed on the carrying tray 31, and the fixing elements can fix the test chip 5 on the carrying tray 31. Can fix a plurality of test chip 5 at a plurality of installation positions of carrying dish 31 through a plurality of fixed subassemblies, when rotary drive device 2 drive carried dish 31 and rotates, can detect a plurality of test chip 5 simultaneously, detection efficiency is higher. Specifically, the fixing assembly comprises a key 33 and a first elastic member 34, the key 33 has a clamping position clamped with the test chip 5 and a separation position separated from the test chip 5, and the first elastic member 34 can drive the key 33 to move from the separation position to the clamping position. The relative positions of the test chip 5 and the carrier disc 31 can be locked or unlocked by pressing the key 33. It should be noted that a key 33 and a first elastic member 34 are provided for each mounting position on the carrier plate 31. Preferably, the chip carrier 3 further comprises a cover plate 32, the cover plate 32 is fixed to the carrier plate 31, and the test chip 5 is clamped between the cover plate 32 and the carrier plate 31 to ensure stable positioning of the test chip 5 in the vertical direction. In this embodiment, the carrier disc 31 is provided with a key hole 314 corresponding to each first elastic member 34, the key 33 is slidably disposed in the key hole 314, and the first elastic members 34 respectively abut against the key 33 and the cover plate 32. The chip main body 51 is further provided with a fixing groove 511, and the key 33 is provided with a hook, so that when the hook is engaged with the fixing groove 511, the hook can lock the relative position of the test chip 5 and the tray 31. In other embodiments, the fixing component may be replaced by a screw or the like, and the fixing between the test chip 5 and the carrier plate 31 may be realized by the screw passing through the chip main body 51 and screwing with the carrier plate 31. In this embodiment, the cover plate 32 is mounted on the carrier plate 31 by screws, and the cover plate 32 and the carrier plate 31 cooperate to clamp only a portion of the outer edge of the test chip 5, so that the first light source module 61 can collect data of the test chip 5.

In this embodiment, the first elastic element 34 is preferably a first compression spring, and in other embodiments, the first elastic element 34 may be replaced by a metal elastic sheet, a plastic elastic sheet, or a rubber pad. Preferably, referring to fig. 16, the key 33 is further provided with an insertion hole 332, and the first elastic member 34 is inserted into the insertion hole 332 to ensure that the elastic deformation direction of the first elastic member 34 is stable.

Optionally, referring to fig. 10, 11 and 13, the chip carrier 3 further includes a push rod 35 and a second elastic member 36, the second elastic member 36 is respectively abutted against the carrier disc 31 and the push rod 35, the test chip 5 is in sliding fit with the carrier disc 31, the test chip 5 can slide relative to the carrier disc 31 and has a pre-assembly position and a loading position, when the test chip 5 is located at the loading position, the push button 33 is clamped with the test chip 5, and the second elastic member 36 can drive the push rod 35 to abut against the test chip 5, so that the push rod 35 always has a tendency of driving the test chip 5 to move from the loading position to the pre-assembly position. It should be noted that two push rods 35 and two second elastic members 36 are provided for each mounting position on the carrier tray 31. By arranging the push rod 35 and the second elastic member 36, after the test chip 5 and the carrying disc 31 are unlocked by pressing the key 33, the push rod 35 can push the test chip 5 to move from the loading position to the pre-loading position under the action of the second elastic member 36, and the operation is simple and convenient. Specifically, a push rod groove 315 is formed in the carrier disc 31 corresponding to each push rod 35, the second elastic element 36 is installed in the push rod groove 315, and the push rod 35 is slidably located in the push rod groove 315. In order to ensure the stable stress of the chip main body 51, a baffle 512 is provided on the chip main body 51, and the push rod 35 abuts against the baffle 512. Preferably, in order to ensure that the sliding directions of the test chip 5 and the tray 12 are stable, the slide groove 316 is provided on the carrier 31, the slide rail 513 is provided on the chip main body 51, and the slide rail 513 is in sliding fit with the slide groove 316, further preferably, two slide rails 513 are oppositely provided on the chip main body 51 along the left-right direction, two slide grooves 316 are correspondingly provided on the carrier 31, and the two slide rails 513 are respectively slidably located in the two slide grooves 316. The test chip 5 can be restricted from moving in the left-right direction by the cooperation of the two slide rails 513 and the two slide grooves 316, wherein the left-right direction is perpendicular to the moving direction of the test chip 5 when moving from the pre-assembly position to the loading position, and the left-right direction is perpendicular to the vertical direction.

In this embodiment, the second elastic element 36 is preferably a second compression spring, and in other embodiments, the second elastic element 36 may be a metal elastic sheet, a plastic elastic sheet, or a rubber pad. Preferably, referring to fig. 15, the push rod 35 includes an insertion portion 352, a sliding portion 351 and a head portion 353, which are connected in sequence, wherein the head portion 353 is used for abutting against the test chip 5, the sliding portion 351 is used for sliding-fitting with the carrying disc 31, and the insertion portion 352 is sleeved with the second compression spring to ensure a stable direction when the second compression spring is elastically deformed.

Optionally, referring to fig. 16, the hook of the key 33 is provided with a key guide surface 331, in the process of pushing the test chip 5 to move from the pre-installed position to the loaded position, the chip main body 51 may abut against the key guide surface 331 and push the key 33 to compress the first elastic member 34, so that the hook of the key 33 is located above the test chip 5, so that the test chip 5 passes over the hook of the key 33 and reaches the loaded position, and when the test chip 5 is located at the loaded position, the hook of the key 33 is clamped into the fixing groove 511 under the action of the first elastic member 34, thereby achieving the position locking of the test chip 5.

Optionally, referring to fig. 14, in the process that the test chip 5 moves from the pre-assembly position to the loading position, in order to ensure that the test chip 5 can stably stop at the loading position, the chip main body 51 is provided with a first limiting surface 514, the carrying disc 31 is provided with a second limiting surface 317, and when the first limiting surface 514 abuts against the second limiting surface 317, the test chip 5 is located at the loading position.

The operating principle of the microfluidic biochemical analyzer is as follows:

1) the test chip 5 is loaded on the carrier tray 31

The two slide rails 513 on the test chip 5 are aligned with the two slide grooves 316 on the carrier tray 31 and push the test chip 5 toward the center of the carrier tray 31 until the first mating surface 415 and the second mating surface 431 are abutted, in the process, the two push rods 35 will gradually compress the second elastic member 36, and the hooks of the keys 33 will be snapped into the fixing grooves 511, so as to lock the relative positions of the test chip 5 and the carrier tray 31.

2) And a sample adding process: after the test chip 5 is loaded on the tray 31, the liquid to be tested is dropped from the loading hole 531 of the test chip 5 into the loading channel 515 by a syringe or a pipette.

3) The chip carrier 3 enters the test chamber 111

The in-out bin motor 15 is started, the in-out bin motor 15 drives the gear 13 to rotate, the gear 13 drives the rack 14 to move, so that the tray 12 drives the chip carrier 3 to move from the testing position to the sample adding position, when the second photoelectric sensor 18 detects the second detection hole 128, the in-out bin motor 15 stops rotating, and the tray 12 is located at the sample adding position at the moment. Install chip carrier 3 to fixed round hole 125, reverse start business turn over storehouse motor 15, business turn over storehouse motor 15 drives gear 13 and rotates, gear 13 drives rack 14 and removes, so that tray 12 drives chip carrier 3 and removes to the test position, in this process, chip carrier 3 and supporting disk 22's direction inclined plane 221 butt, and remove and progressively move to supporting disk 22 along direction inclined plane 221, when first photoelectric sensor 17 detects first inspection hole 127, business turn over storehouse motor 15 stall, tray 12 is located the test position this moment, and chip carrier 3 separates completely with tray 12 and supports in supporting disk 22.

4) And heating the mixture

Go up heating body 71 and lower heating body 72 circular, in order to guarantee that the temperature in test bin 111 keeps the required test temperature always, in order to eliminate the influence of ambient temperature to test process, test result by adding the real-time temperature of two heating bodies of two temperature sensor 73 detection, when reaching the required temperature, stop heating body 71 and lower heating body 72 heating, if after the temperature reduction, go up heating body 71 and lower heating body 72 circular.

5) And locking the same

When the electric push rod starts to work, the moving shaft 421 drives the pressure plate 412 and the suction block 411 to move downwards through the top shaft 43, and when the first sensor 45 detects the sensing piece 46, at this time, the suction block 411 is inserted into the fixing hole 311 and is sucked with the magnetic piece 23, the top shaft 43 abuts against the pressing surface 416, the pressure plate 412 presses on the cover plate 32 of the chip carrier 3 to press the carrier plate 31 on the supporting plate 22, and the relative position of the chip carrier 3 and the supporting plate 22 can be locked. Then, the electric push rod rotates in the opposite direction, the moving shaft 421 drives the top shaft 43 to move upward for a certain distance, so that the top shaft 43 is located in the second matching hole 414, the top shaft 43 is completely separated from the platen 412, and the rotation test of the main motor 21 is waited.

6) Unlocking of the lock

After the test is completed, the electric push rod starts to work, the moving shaft 421 drives the top shaft 43 to enter the first matching hole 413, and continues to drive the pressure plate 412 and the suction block 411 to move upwards through the top shaft 43, so that the magnetic member 23 and the suction block 411 are separated. When the second sensor 47 detects the sensor 46, the electric push rod stops working, and at this time, the suction block 411 is higher than the chip carrier 3, so as to unlock the chip carrier 3, the in-out motor 15 starts working, the tray 12 is driven to withdraw the chip carrier 3 from the test chamber 111, and the test is completed.

It is obvious that the above embodiments of the present invention are only examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.

Claims (10)

1. A locking device is characterized by comprising a driving piece (42), a top shaft (43) and a locking piece (41) used for pressing a chip carrier (3);

the driving piece (42) is provided with a moving shaft (421) capable of reciprocating along the vertical direction, and the top shaft (43) is arranged at the end part of the moving shaft (421);

retaining member (41) rotationally the cover is located apical axis (43), retaining member (41) can under self action of gravity with apical axis (43) along vertical direction butt, just when retaining member (41) compress tightly chip carrier (3), motion axle (421) can drive apical axis (43) is relative retaining member (41) motion, so that apical axis (43) with retaining member (41) separate along vertical direction.

2. Locking device according to claim 1, characterized in that the locking element (41) has a mating hole, the top shaft (43) is rotatably inserted into the mating hole, and the top shaft (43) is slidable in a vertical direction relative to the wall of the mating hole.

3. The locking device according to claim 2, wherein the fitting hole comprises a first fitting hole (413) and a second fitting hole (414) which are communicated, the diameter of the first fitting hole (413) is matched with the outer diameter of the top shaft (43), and the diameter of the second fitting hole (414) is larger than the outer diameter of the top shaft (43);

the top shaft (43) can slide between the first matching hole (413) and the second matching hole (414) relative to the locking piece (41), and when the locking piece (41) abuts against the top shaft (43) in the vertical direction under the action of self gravity, the top shaft (43) is located in the first matching hole (413); when the top shaft (43) is vertically separated from the locker (41), the top shaft (43) is located at the second fitting hole (414).

4. Locking device according to claim 3, characterized in that the locking element (41) comprises a pressure plate (412) and a suction block (411) arranged on the pressure plate (412), the mating hole is arranged on the pressure plate (412), the chip carrier (3) has a fixing hole (311), and the suction block (411) is plugged into the fixing hole (311) when the pressure plate (412) abuts against the chip carrier (3).

5. Locking device according to claim 4, characterized in that it further comprises a first non-slip pad (48), said first non-slip pad (48) being arranged on the lower end face of said platen (412), said platen (412) being adapted to press said first non-slip pad (48) against said chip carrier (3).

6. The locking device according to claim 4, wherein the suction block (411) is partially inserted into the second fitting hole (414), and the suction block (411) has a pressing surface (416) located in the second fitting hole (414), and the top shaft (43) can abut against or separate from the pressing surface (416).

7. Locking device according to claim 3, characterized in that a conical transition surface is provided between the first mating hole (413) and the second mating hole (414).

8. Locking device according to claim 1, characterized in that said top shaft (43) is screwed to said movement shaft (421).

9. Locking device according to claim 1, characterized in that the locking member (41) has a locked position pressed against the chip carrier (3) and an unlocked position separated from the chip carrier (3), the actuating member (42) being capable of actuating the locking member (41) between the locked position and the unlocked position;

the locking device also comprises a first sensor (45) and a second sensor (47), and a sensing piece (46) is fixed on the moving shaft (421); when the first sensor (45) is engaged with the sensing tab (46), the locking member (41) is in the locking position; when the second sensor (47) is engaged with the sensing tab (46), the locking member (41) is in the unlocked position.

10. A microfluidic biochemical analyzer, comprising the locking device of any one of claims 1-9.

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