CN213951155U

CN213951155U - Portable device for preparing medicinal red blood cells

Info

Publication number: CN213951155U
Application number: CN202022935142.0U
Authority: CN
Inventors: 叶永清; 黄能平; 伊莉莉
Original assignee: Xiamen Sany Hematopoietic Technology Co ltd
Current assignee: Xiamen Sany Hematopoietic Technology Co ltd
Priority date: 2020-12-09
Filing date: 2020-12-09
Publication date: 2021-08-13
Anticipated expiration: 2030-12-09

Abstract

The utility model discloses a portable device for preparing medicinal red blood cells, which belongs to the technical field of red blood cell biology, and comprises a bottom plate, wherein a reaction box is placed on one side above the bottom plate, a baffle is connected to the inner part of the reaction box close to the lower part, a driving motor is installed at the middle position below the baffle, a centrifugal chamber is arranged at the output shaft end of the driving motor, a reaction chamber is arranged in the reaction box and above the centrifugal chamber, and the outer wall close to the upper part of the reaction chamber is connected with the inner wall of the reaction box through a plurality of support rods; the utility model discloses set up reaction box, baffle, driving motor, layer board, centrifugal chamber, reacting chamber, drain pipe, control valve, red blood cell unicellular suspension storage box, modified liquid storage box, medicine storage box, inlet tube, peristaltic pump, outlet pipe, waste liquid collecting box and collecting pipe, mutually supporting between the structure can realize the automated production of red blood cell medicine, easy operation.

Description

Portable device for preparing medicinal red blood cells

Technical Field

The utility model belongs to the technical field of erythrocyte biology, concretely relates to portable equipment for preparing medicine erythrocyte.

Background

Erythrocytes are the largest number of blood cells in the blood, and have a great deformability, enabling them to pass smoothly through capillaries smaller than their own diameter.

Research shows that when erythrocytes are in a slightly hypotonic environment (about 1/2 of plasma osmotic pressure), external water can enter erythrocytes to cause reversible expansion of 154-174% and become elliptical, when a hemolysis critical point is reached, pores with the diameter of 20-50 nm on erythrocyte membranes are opened transiently, external polypeptides, proteins, enzymes, drugs and the like can enter erythrocyte cavities through the pores, when the surrounding environment of erythrocytes returns to an isotonic state, the erythrocytes can be reduced and restored, the pores on the membranes also contract, and the characteristics of the erythrocytes determine that specific drugs can be encapsulated in the erythrocytes, and in addition, the erythrocytes as a drug carrier have incomparable advantages compared with a synthetic drug carrier: 1) ideal biocompatibility and biodegradability; 2) reducing the immunogenicity of the foreign substance; 3) improve the stability of the medicine in vivo.

The existing preparation methods for producing erythrocyte medicines are basically based on osmotic pressure change, and comprise an early hypotonic hemolysis method, a hypotonic dilution method, an improved hypotonic dialysis method and a hypotonic pre-swelling method, the methods change the permeability of erythrocyte membranes by manual operation so as to achieve the purpose of embedding medicines, have the problems of complicated operation and no standardized flow, have the problems of non-uniform performance and unstable batch of produced erythrocyte medicines, and need an automatic production flow with simple operation so as to reduce the batch difference of products.

SUMMERY OF THE UTILITY MODEL

To solve the problems set forth in the background art described above. The utility model provides a portable equipment of preparation medicine erythrocyte has easy operation, and automated production flow is in order to reduce the characteristics that the product is criticized poor.

In order to achieve the above object, the utility model provides a following technical scheme: a portable device for preparing drug red blood cells comprises a bottom plate, wherein a reaction box is placed on one side above the bottom plate, a partition plate is connected to the inner portion of the reaction box close to the lower portion, a driving motor is installed at the middle position below the partition plate, a centrifugal chamber is arranged at the output shaft end of the driving motor, a reaction chamber is arranged in the reaction box and above the centrifugal chamber, the outer wall of the reaction chamber close to the upper portion is connected with the inner wall of the reaction box through a plurality of support rods, a liquid outlet pipe is connected to one side of the reaction chamber close to the lower portion, a water outlet of the liquid outlet pipe extends into the centrifugal chamber, a control valve is arranged on the liquid outlet pipe, a red blood cell single cell storage box, a modified liquid storage box, a drug storage box and a waste liquid collection box are respectively placed on the other side above the bottom plate in sequence, a support plate is connected to one side, three peristaltic pumps are placed on the supporting plate, the erythrocyte single cell suspension storage box, the modified solution storage box and the medicine storage box are connected with the corresponding peristaltic pumps through water inlet pipes, the water outlet ends of the three peristaltic pumps are connected with water outlet pipes, the water outlet ends of the three water outlet pipes extend into the reaction chamber, and the waste liquid collection box is connected with the reaction chamber through collection pipes.

Preferably, the output shaft end of the driving motor is connected with a supporting plate, and the supporting plate is fixed with the centrifugal chamber in an adhesive manner.

Preferably, the cross-sectional area of the centrifugal chamber is larger than the cross-sectional area of the reaction chamber.

Preferably, labels are arranged on the erythrocyte single cell suspension storage tank, the modification liquid storage tank, the medicine storage tank and the waste liquid collection tank.

Preferably, the water outlet pipe and the reaction box are limited through a support frame.

Preferably, the reaction box is provided with heat dissipation holes at positions corresponding to the driving motor.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses set up reaction box, baffle, driving motor, layer board, centrifugal chamber, reacting chamber, drain pipe, control valve, red blood cell unicellular suspension storage box, modified liquid storage box, medicine storage box, inlet tube, peristaltic pump, outlet pipe, waste liquid collecting box and collecting pipe, mutually supporting between the structure can realize the automated production of red blood cell medicine, easy operation.

2. The utility model discloses automated production erythrocyte medicine, the flow is standardized, can solve the present erythrocyte medicine performance of producing inhomogenous, and the unstable problem of batch reduces the product batch poor.

Drawings

Fig. 1 is a front view of the present invention;

FIG. 2 is a schematic side view of the present invention;

FIG. 3 is a schematic structural view of the present invention;

FIG. 4 is a schematic sectional view of the present invention;

in the figure: 1. a base plate; 2. a reaction box; 3. a support frame; 4. a water outlet pipe; 5. a peristaltic pump; 6. a support plate; 7. a water inlet pipe; 8. a storage box for the single cell suspension of the red blood cells; 9. a label; 10. a collection pipe; 11. a waste liquid collection box; 12. a drug storage case; 13. a modifying liquid storage tank; 14. a centrifugal chamber; 15. a liquid outlet pipe; 16. a control valve; 17. a reaction chamber; 18. a support bar; 19. a partition plate; 20. a drive motor; 21. and (7) a supporting plate.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-4, the present invention provides the following technical solutions: a portable device for preparing drug red blood cells comprises a bottom plate 1, a reaction box 2 is placed on one side above the bottom plate 1, a partition plate 19 is connected to the inner portion of the reaction box 2 close to the lower portion, a driving motor 20 is installed at the middle position below the partition plate 19, a centrifugal chamber 14 is arranged at the output shaft end of the driving motor 20, a reaction chamber 17 is arranged in the reaction box 2 and above the centrifugal chamber 14, the outer wall of the reaction chamber 17 close to the upper portion is connected with the inner wall of the reaction box 2 through a plurality of support rods 18, a liquid outlet pipe 15 is connected to one side of the reaction chamber 17 close to the lower portion, the water outlet of the liquid outlet pipe 15 extends into the centrifugal chamber 14, a control valve 16 is arranged on the liquid outlet pipe 15, a red blood cell single cell suspension storage box 8, a modification liquid storage box 13, a drug storage box 12 and a waste liquid collection box 11 are respectively placed on the other side above the bottom plate 1 in sequence, a single cell support plate 6 is connected to one side wall of the reaction box 2 close to the red blood cell suspension storage box 8, three peristaltic pumps 5 are placed on the supporting plate 6, the erythrocyte single cell suspension storage tank 8, the modified liquid storage tank 13 and the medicine storage tank 12 are connected with the corresponding peristaltic pumps 5 through the water inlet pipe 7, the water outlet ends of the three peristaltic pumps 5 are connected with the water outlet pipe 4, the water outlet ends of the three water outlet pipes 4 extend into the reaction chamber 17, and the waste liquid collecting tank 11 is connected with the reaction tank 2 through the collecting pipe 10.

Specifically, the output shaft end of the driving motor 20 is connected with a supporting plate 21, the supporting plate 21 and the centrifugal chamber 14 are fixed in an adhesive manner,

by adopting the technical scheme, the supporting plate 21 can increase the contact area with the centrifugal chamber 14, and the rotation stability and the centrifugal effect of the centrifugal chamber 14 are improved.

In particular, the cross-sectional area of the centrifugal chamber 14 is greater than the cross-sectional area of the reaction chamber 17,

by adopting the technical scheme, the red blood cell medicament in the centrifugal chamber 14 can be taken out conveniently by workers.

Specifically, labels 9 are arranged on the erythrocyte single cell suspension storage tank 8, the modified liquid storage tank 13, the medicine storage tank 12 and the waste liquid collection tank 11,

by adopting the technical scheme, the corresponding substances in the storage box can be conveniently and clearly known by workers, and the subsequent addition is convenient.

In particular, the water outlet pipe 4 and the reaction box 2 are limited by a support frame 3,

by adopting the technical scheme, the water outlet pipes 4 can be neatly arranged on the side wall of the reaction box 2.

Specifically, the reaction box 2 is provided with heat dissipation holes corresponding to the driving motor 20,

through adopting above-mentioned technical scheme, make things convenient for driving motor 20 heat dissipation.

The utility model discloses a theory of operation and use flow: the erythrocyte single cell suspension in the erythrocyte single cell suspension storage box 8 and the modification liquid in the modification liquid storage box 13 are transmitted to the reaction chamber 17 through the peristaltic pump 5, the medicine in the medicine storage box 12 is transmitted to the reaction chamber 17 through the peristaltic pump 5, after reaction, the control valve 16 is opened, the reactant in the reaction chamber 17 enters the centrifugal chamber 14 through the liquid outlet pipe 15, the driving motor 20 is electrified to work, the driving motor 20 drives the supporting plate 21 to rotate, the supporting plate 21 drives the centrifugal chamber 14 to rotate (300g centrifugation for 10min), the erythrocyte embedded with the medicine is left in the centrifugal chamber 14 through centrifugation, the waste liquid reaches the waste liquid collecting box 11 through the collecting pipe 10, the waste liquid collection is completed, and the embedded medicine erythrocyte in the centrifugal chamber 14 is taken by a worker.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A portable device for preparing red blood cells of a drug, comprising a base plate (1), characterized in that: reaction box (2) are placed to top one side of bottom plate (1), the inside of reaction box (2) is connected with baffle (19) by the below, driving motor (20) are installed to the below intermediate position of baffle (19), the output shaft end of driving motor (20) is provided with centrifugal chamber (14), the inside of reaction box (2) and the top that is located centrifugal chamber (14) are provided with reaction chamber (17), the inner wall that leans on top outer wall and reaction box (2) of reaction chamber (17) is connected through a plurality of bracing piece (18) within a definite time, one side of reaction chamber (17) is leaned on the below and is connected with drain pipe (15), the delivery port of drain pipe (15) extends to in centrifugal chamber (14), be provided with control valve (16) on drain pipe (15), red cell suspension storage box (8) have been placed respectively according to the order to the top opposite side of bottom plate (1), Modified liquid storage box (13), medicine storage box (12) and waste liquid collecting box (11), a lateral wall that just is close to red blood cell unicellular suspension storage box (8) on reaction box (2) is connected with backup pad (6), three peristaltic pump (5) have been placed on backup pad (6), red blood cell unicellular suspension storage box (8), modified liquid storage box (13) and medicine storage box (12) are connected through inlet tube (7) with corresponding peristaltic pump (5) within a definite time, and are three the play water end of peristaltic pump (5) all is connected with outlet pipe (4), and is three the play water end of outlet pipe (4) all extends to in reaction chamber (17), be connected through collecting pipe (10) between waste liquid collecting box (11) and reaction box (2).

2. The portable device for preparing medicinal red blood cells according to claim 1, wherein: the output shaft end of the driving motor (20) is connected with a supporting plate (21), and the supporting plate (21) and the centrifugal chamber (14) are fixed in an adhesive mode.

3. The portable device for preparing medicinal red blood cells according to claim 1, wherein: the cross-sectional area of the centrifugal chamber (14) is larger than the cross-sectional area of the reaction chamber (17).

4. The portable device for preparing medicinal red blood cells according to claim 1, wherein: labels (9) are arranged on the erythrocyte single cell suspension storage tank (8), the modified liquid storage tank (13), the medicine storage tank (12) and the waste liquid collection tank (11).

5. The portable device for preparing medicinal red blood cells according to claim 1, wherein: the water outlet pipe (4) and the reaction box (2) are limited through the support frame (3).

6. The portable device for preparing medicinal red blood cells according to claim 1, wherein: the reaction box (2) is provided with heat dissipation holes corresponding to the positions of the driving motors (20).