CN213525691U - A simulated jaw implant based on 3D printed porous titanium alloy - Google Patents
A simulated jaw implant based on 3D printed porous titanium alloy Download PDFInfo
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- CN213525691U CN213525691U CN202021602429.5U CN202021602429U CN213525691U CN 213525691 U CN213525691 U CN 213525691U CN 202021602429 U CN202021602429 U CN 202021602429U CN 213525691 U CN213525691 U CN 213525691U
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Abstract
本实用新型公开了一种基于3D打印多孔钛合金的仿真颌骨植入物，属于生物医学材料技术领域。所述仿真颌骨植入物包括颌骨体和接骨板，所述颌骨体与接骨板为3D打印的一体结构，所述颌骨体包括骨皮质层和骨松质层，其中所述骨皮质层位于骨松质层外周，包绕骨松质层，骨皮质层和骨松质层均为立体多孔钛合金结构，所述接骨板位于颌骨体的两端并留有钉孔用于固定在宿主骨面上。所述植入物为与患者颌骨缺损部位的形态相匹配并且与颌骨原有结构相似的多孔钛合金植入物。本实用新型所述的植入物可用于修复颌骨缺损，其多孔结构有助于新生骨及血管的长入，加速新骨的形成，从而加速骨愈合，有效地维持植入物与宿主骨之间长期稳定地生物固定。
The utility model discloses a simulated jaw implant based on 3D printing porous titanium alloy, which belongs to the technical field of biomedical materials. The artificial jaw implant includes a jaw body and a bone plate, the jaw body and the bone plate are a 3D printed one-piece structure, the jaw body includes a cortical bone layer and a cancellous bone layer, wherein the bone The cortical layer is located on the outer periphery of the cancellous bone layer and surrounds the cancellous bone layer. Both the cortical bone layer and the cancellous bone layer are three-dimensional porous titanium alloy structures. fixed on the host bone. The implant is a porous titanium alloy implant that matches the shape of the defect site of the patient's jaw and is similar to the original structure of the jaw. The implant described in the utility model can be used to repair the defect of the jaw, and its porous structure helps the growth of new bone and blood vessels, accelerates the formation of new bone, thus accelerates bone healing, and effectively maintains the implant and the host bone. long-term stable biofixation.
Description
Technical Field
The utility model belongs to the technical field of biomedical materials, concretely relates to emulation jaw bone implant based on porous titanium alloy is printed to 3D.
Background
The maxillofacial bone defect is a common clinical disease and frequently encountered disease of the maxillofacial region, and is usually caused by severe maxillofacial trauma, tumor postoperative, inflammatory infection, physiological bone atrophy and the like. The maxillofacial bone defect seriously affects the facial appearance and oral function of a patient, and hinders the work and life of the patient, and the restoration of the maxillofacial bone defect is a difficult problem relating to various theories and technologies. The improvement and innovation of the technical method can improve the clinical treatment level of the maxillofacial bone defect, and have important theoretical and practical significance for improving the life quality of patients. The jaw and face anatomy structure is complex and involves various physiological functions, such as chewing, swallowing, eating, speaking and the like, so that the repair and reconstruction are more difficult compared with other parts of the body, and the problem still needs to be solved clinically at present.
The existing bone repair technology mainly comprises autologous bone transplantation, allogeneic bone transplantation, biological material implantation and the like. The autologous bone transplantation needs to open up a second operation area, increases the trauma of patients, and has the problem of limited bone source, and the allogeneic bone transplantation has the problems of immunological rejection, potential infectious diseases and the like, so the clinical application of the autologous bone transplantation and the allogeneic bone transplantation is relatively limited. Therefore, biomaterials, bone-guided regeneration and bone tissue engineering are the most promising bone repair technologies.
In the last 30 years, in order to develop a scaffold material capable of simulating natural bone tissue, a lot of experiments are carried out by scholars at home and abroad. Common scaffold materials are: natural polymer materials, artificially synthesized organic polymer materials, and artificially synthesized inorganic materials. The natural polymer material such as collagen has the advantages of being similar to human extracellular matrix, having stable biological activity, being easy to degrade and absorb, but having poor mechanical strength. Artificially synthesized organic polymer materials such as polylactic acid (PLA) have good biocompatibility, plasticity and metabolizability, but have some obvious disadvantages, such as too fast degradation speed, early failure of bone tissue transplantation, and aseptic inflammation of organisms caused by degradation of the obtained acid products. Biosynthetic inorganic materials such as hydroxyapatite, bioceramics, while the human bone-like microporous structure facilitates revascularization, such materials also have their own deficiencies, such as greater brittleness, poor mechanical resistance, inability to be plastic, etc. Therefore, these scaffold materials are only used for reparative reconstruction of small bone tissue defects, such as alveolar ridge reconstruction and bone augmentation in the implant area. For the repair and reconstruction of large-area bone tissue defects, much effort is still required to develop new scaffold materials.
With the rapid development of computer-assisted surgery, 3D printing and tissue engineering, new means are continuously provided for the repair and reconstruction of the bone defect of the maxillofacial region, and students also obtain abundant results, however, the ideal prosthesis is still not developed successfully.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to prior art not enough, provide a emulation jaw bone implant based on porous titanium alloy is printed to 3D, can be used to restore the jaw and be defective, its porous structure helps the new bone and vascular growing into, accelerates the formation of new bone to bone healing accelerates, maintain the biological fixation steadily for a long time between implant and the host bone effectively.
In order to achieve the above purpose, the utility model discloses a following technical scheme realizes:
the utility model provides a simulation jaw bone implant based on porous titanium alloy is printed to 3D, includes jaw diaphysis and coaptation board, jaw diaphysis and coaptation board are the integrative structure that 3D printed, jaw body includes bone cortex layer and bone pine layer, wherein the bone cortex level is located bone pine layer periphery, wraps bone pine layer, just bone cortex layer and bone pine layer are three-dimensional porous titanium alloy structure, the coaptation board is located jaw diaphysis's both ends and leaves the nail hole and is used for fixing on the host bone face.
Preferably, the bone plates are positioned at two ends of the jaw bone body, two bone plates with the thickness of 2.0-2.5mm are respectively arranged at the two ends, and further, the thickness of the bone plates is 2.0 mm.
Preferably, the bone fracture plate is in a strip shape, and three nail holes are respectively formed along the length direction and are used for being fixed on the surface of a host bone; except for the nail holes, the bone fracture plate is of a solid structure, namely, has no pores.
The porous titanium alloy structure of the bone cortex layer has a porosity of 5-15%, and in one embodiment, the porosity of the bone cortex layer is 10%.
Preferably, the thickness of the bone cortex layer is 1.8-2.5mm, and further, the thickness of the bone cortex layer is 2.0 mm.
Preferably, the porosity of the porous titanium alloy structure of the bone loose layer is 55-65%, and in a specific embodiment, the porosity of the bone loose layer is 60%.
Preferably, the pores of the bone cortex layer and the bone loose layer have the same pore diameter, but the number of the pores is different.
In one embodiment, the jaw bone body and the bone plate are both made of Ti6Al 4V. The Ti-6Al-4V is a titanium alloy mark, and comprises the following main components in percentage by mass: al: 5.5% -6.75%, V: 3.5 to 4.5 percent of Ti, and the balance of Ti. The Ti-6Al-4V alloy is widely applied due to good heat resistance, strength, plasticity, toughness, formability, weldability, corrosion resistance and biocompatibility, and can be used as a medical orthopedic implant material. Ti6Al4V may also be formed by 3D printing.
Preferably, the jaw bone body and the bone fracture plate are integrally prepared through 3D printing.
And the two ends of the bone loose layer at the same side with the bone fracture plate are not wrapped by the bone cortex layer, and the two ends of the bone loose layer are used for being connected with the broken ends of the human bones.
Preferably, the jaw body form is designed as a jaw original form.
Compared with the prior art, the utility model has the advantages of it is following:
1. the utility model discloses human natural bone tissue structure of simulation has the bone cortex layer and the bone pine layer of different porosities, reaches the hardness of approximate human cortex bone and the hole of human cancellous bone, and the constitutional unit body accumulation by a little regular tetrahedron forms three-dimensional porous structure in the microcosmic to reduce stress and shelter from the effect and induce bone tissue and vascular tissue to grow into, realize autologous bone and titanium alloy support integration restoration and rebuild, reach long-term stable biological fixation effect.
2. The utility model discloses print into porous titanium alloy support Ti6Al4V, make the whole form of implant approximate the original form of every patient jaw, implant the internal back of patient, with tissues such as bone, muscle, mucosa more laminate around, obtain the facial profile and the jaw arch form of ideal, realize the target of individualized restoration reconstruction.
3. The utility model discloses can effectively shorten the operation time, reduce the operation degree of difficulty, obviously improve the defective restoration of bone and rebuild the accuracy nature, and avoided the development second art district, reduced the operation wound for the postoperative resumes, reduced postoperative complication.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic vertical sectional structure of a jaw body.
Fig. 3 is a schematic view of the present invention in use.
The reference numbers in the figures are: 1. a mandible; 2. a bone plate; 3. a cortical bone layer; 4. a cancellous layer of bone; 5. nail hole
Detailed Description
Embodiments of the present invention will now be described, with reference to the drawings, wherein like parts are designated by like reference numerals throughout.
As shown in fig. 1-2, the utility model provides a technical solution: the utility model provides a simulation jaw bone implant based on porous titanium alloy is printed to 3D, includes jaw diaphysis 1 and four coaptation boards 2, jaw diaphysis 1 and coaptation board 2 are as an organic whole, are printed by the 3D printer and form, jaw diaphysis 1 includes bone cortex 3 and bone cortex 4, wherein bone cortex 3 is located bone cortex 4 periphery, wraps around bone cortex 4, and thickness is 2.5mm, bone cortex 4 is located inside bone cortex 3, is wrapped by bone cortex 4, coaptation board 2 is located jaw diaphysis 1's both ends, and each end respectively two, and thickness is 1mm to three nail hole 5 respectively remain.
In the embodiment, the bone fracture plate is in a strip shape, and three nail holes are respectively arranged along the length direction and are used for being fixed on the surface of a host bone; except for the nail holes, the bone fracture plate is of a solid structure, namely, has no pores.
In this example, the porosity of the porous titanium alloy structure of the bone cortex layer was 10%. The porosity of the porous titanium alloy structure of the bone loose layer is 60%. And the pore diameters of the pores of the bone loose layer and the bone cortical layer are the same, and the porosity of the pores and the porosity of the bone cortical layer are adjusted by different numbers of the pores.
In the embodiment, the jaw bone body and the bone plate are both made of Ti6Al 4V. The mandible and the bone fracture plate are both prepared by 3D printing. And the two ends of the bone loose layer at the same side with the bone fracture plate are not wrapped by the bone cortex layer, and the two ends of the bone loose layer are used for being connected with the broken ends of the human bones.
The specific design, manufacture and application of the simulated jaw bone implant comprise the following implementation steps:
(1) and performing maxillofacial scanning by adopting 16-layer Brilliance CT (computed tomography) of Philips before operation, collecting preoperative spiral CT data of a patient, importing the CT data of the patient into Mimics16.0 software, and performing three-dimensional model reconstruction.
(2) The three-dimensional reconstruction model obtained in the step (1) is turned over to the affected side by adopting a mirror image technology to determine the normal anatomical structure and contour of the affected side, and the structural unit body is filled by taking the anatomical structure and contour as a template,
(3) and (2) the structural unit bodies are regular tetrahedrons (the aperture is 400um, and the beam diameter is 200um), regular and uniform three-dimensional extension and expansion are carried out, and the regular and uniform three-dimensional extension and expansion are gradually accumulated, so that a three-dimensional isotropic uniform three-dimensional porous structure is formed, the porosity of the porous structure of the bone cortex layer 3 is controlled to be about 10%, and the porosity of the porous structure of the bone cortex layer 4 is controlled to be about 60%.
(4) And (4) storing the data of the three-dimensional porous structure obtained in the step (3) into an STL format, introducing the data into a metal 3D printer, and printing and forming the Ti6Al4V powder.
(5) As shown in fig. 3, the 3D printed implant obtained in step (4) is placed into a jaw bone defect of a patient during operation, closely attached to surrounding bone, muscle mucosa and other tissues, and screwed into the nail holes 5 through screws to fix the implant and the host bone together.
The utility model discloses human natural bone tissue structure of simulation has the bone cortex layer and the bone pine layer of different porosities, reaches the hardness of approximate human cortex bone and the hole of human cancellous bone, and the constitutional unit body accumulation by a little regular tetrahedron forms three-dimensional porous structure in the microcosmic to reduce stress and shelter from the effect and induce bone tissue and vascular tissue to grow into, realize autologous bone and titanium alloy support integration restoration and rebuild, reach long-term stable biological fixation effect.
The above-mentioned embodiments are only preferred embodiments of the present invention, and the ordinary changes and substitutions performed by those skilled in the art within the technical scope of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A simulation jaw bone implant based on 3D printing porous titanium alloy comprises a jaw bone body (1) and a bone fracture plate (2), and is characterized in that: the utility model discloses a three-dimensional porous titanium alloy bone plate, including jaw diaphysis (1) and coaptation board (2), the integrative structure that 3D printed, jaw diaphysis (1) includes bone cortex layer (3) and bone pine layer (4), wherein bone cortex layer (3) are located bone pine layer (4) periphery, wrap up bone pine layer (4), just bone cortex layer (3) and bone pine layer (4) are three-dimensional porous titanium alloy structure, coaptation board (2) are located the both ends of jaw diaphysis (1) and leave nail hole (5) and are used for fixing on the host bone face.
2. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the bone plates (2) are positioned at two ends of the jaw bone body (1), and two bone plates (2) with the thickness of 2.0-2.5mm are respectively arranged at the two ends.
3. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the bone fracture plate (2) is in a strip shape, three nail holes (5) are respectively formed in the length direction and used for being fixed on the surface of a host bone, and the bone fracture plate is of a solid structure except the nail holes.
4. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the porosity of the porous titanium alloy structure of the bone cortex layer (3) is 5-15%.
5. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the thickness of the bone cortex layer (3) is 1.8-2.5 mm.
6. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the porosity of the porous titanium alloy structure of the bone loose layer (4) is 55-65%.
7. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the jaw bone body (1) and the bone plate (2) are both made of Ti6Al 4V.
8. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the mandible (1) and the bone fracture plate (2) are both prepared by 3D printing.
9. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: and the two ends of the bone loose layer (4) at the same side with the bone fracture plate (2) are not wrapped by the bone cortex layer (3).
10. The 3D printed porous titanium alloy-based simulated jaw bone implant according to claim 1, wherein: the shape of the jaw bone body (1) is designed to be the original shape of the jaw bone.
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| CN202021602429.5U CN213525691U (en) | 2020-08-05 | 2020-08-05 | A simulated jaw implant based on 3D printed porous titanium alloy |
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| CN202021602429.5U CN213525691U (en) | 2020-08-05 | 2020-08-05 | A simulated jaw implant based on 3D printed porous titanium alloy |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200726A (en) * | 2019-06-25 | 2019-09-06 | 上海交通大学医学院附属第九人民医院 | Mandibular defect dummy |
| CN116688242A (en) * | 2023-05-26 | 2023-09-05 | 华南理工大学 | Titanium/tantalum composite porous bone defect repair stent and preparation method thereof |
-
2020
- 2020-08-05 CN CN202021602429.5U patent/CN213525691U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110200726A (en) * | 2019-06-25 | 2019-09-06 | 上海交通大学医学院附属第九人民医院 | Mandibular defect dummy |
| CN110200726B (en) * | 2019-06-25 | 2024-09-13 | 上海交通大学医学院附属第九人民医院 | Mandibular defect restoration |
| CN116688242A (en) * | 2023-05-26 | 2023-09-05 | 华南理工大学 | Titanium/tantalum composite porous bone defect repair stent and preparation method thereof |
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