CN210644251U - A tubular porous titanium alloy prosthesis of 3D printing for big section bone defect of four limbs - Google Patents
A tubular porous titanium alloy prosthesis of 3D printing for big section bone defect of four limbs Download PDFInfo
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- CN210644251U CN210644251U CN201921005835.0U CN201921005835U CN210644251U CN 210644251 U CN210644251 U CN 210644251U CN 201921005835 U CN201921005835 U CN 201921005835U CN 210644251 U CN210644251 U CN 210644251U
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Abstract
A3D printed tubular porous titanium alloy prosthesis for the defects of the large bones of limbs is characterized in that a hollow tubular porous prosthesis with a bone fracture plate is designed according to thin-layer CT scanning data of a patient, an operation path and a bone cutting plane shape of a diseased region are combined, prosthesis design data are led into metal 3D printing equipment to prepare a tubular porous titanium alloy prosthesis, the prepared tubular porous titanium alloy prosthesis is placed in electrolyte of calcium acetate and β sodium glycerophosphate to carry out micro-arc oxidation treatment on the tubular porous titanium alloy prosthesis, then the tubular porous titanium alloy prosthesis is processed in constant-temperature water bath to obtain a 3D printed tubular titanium alloy prosthesis with titanium oxide on the surface, and the 3D printed tubular titanium alloy prosthesis is placed in Ba (OH)2In the solution, the PH value is adjusted to 13 to react with the titanium oxide in the tubular titanium alloy for 3D printingBarium titanate is generated on the surface of the prosthesis. The surface active treatment of the utility model improves the biocompatibility of the prosthesis, induces the growth of new bones and achieves good osseointegration effect; the integrated bone fracture plate has high fit with the backbone, and the fixing reliability is improved.
Description
Technical Field
The utility model relates to a tubulose porous titanium alloy false body, concretely relates to be used for the defective 3D of big section bone of four limbs to print tubulose porous titanium alloy false body.
Background
The repair of large bone defects caused by wounds, tumors, infections, and the like is a common and troublesome problem in clinical practice at present. Allogeneic bone and autologous fibula with blood vessels are currently the most common long bone defect repair methods. Allogenic bone has the advantage of providing bone mass and early support, but has a long activation time, a low rate of healing with the recipient, and is susceptible to infection. The autogenous vascular bone has the advantages of living bone transplantation, high healing rate and certain anti-infection capacity, but is not suitable for being used for lower limb bone defect alone due to thin tube diameter, and the occurrence rate of secondary fracture in the remodeling process after fibula healing is high.
Although the titanium alloy (Ti-6Al-4V) used clinically at present has good mechanical strength, the titanium alloy still has obvious defects in the clinical application process: 1. the elastic modulus (110GPa) is far higher than that of normal bone (the cortical bone is about 15GPa), so that stress shielding is generated, bone absorption is caused, and the bone-metal interface integration is poor; 2. titanium alloy is a biologically inert material and does not have a good stimulating effect on bone formation around the material, resulting in a slower bone in-growth amount and in-growth speed. The bulk phase porous titanium alloy well solves the problem, mainly shows that the internal structure is uniform, no obvious interface effect exists, the internal communicated pore structure also provides a good growing environment for the new bone tissue, and the material strength and modulus can be matched with natural bone through adjusting the parameters of the porous structure, so the bulk phase porous titanium alloy is an ideal orthopedic metal implant material.
The 3D printing technique is a technique for constructing an object by printing layer by layer on the basis of a digital model. The porous titanium alloy bone repair prosthesis which is accurately matched with the bone defect can be obtained through a 3D printing technology, and the strength close to that of a normal bone is obtained through gap and structure adjustment; meanwhile, the 3D printing prosthesis is not limited by the shape of the bone defect, residual bone does not need to be trimmed too much, and individualized, accurate and precise reconstruction treatment is realized on the premise that the bone is reserved as much as possible. The 3D printed porous titanium alloy prosthesis has certain bone ingrowth capacity, can be tightly combined with bone, and can further improve the bone ingrowth capacity of the prosthesis by carrying out piezoelectric ceramic surface modification treatment on the prosthesis. The fibula and the 3D printed porous titanium alloy prosthesis are organically combined, so that the mechanical support of the prosthesis, the osteogenesis and anti-infection effects of the fibula are exerted, and the perfect combination of mechanical reconstruction and biological reconstruction can be realized.
SUMMERY OF THE UTILITY MODEL
The utility model aims to overcome the defects of the prior four-limb large-section bone defect treatment method and provide a 3D printing tubular porous titanium alloy prosthesis for the four-limb large-section bone defect.
In order to achieve the above purpose, the utility model adopts the technical scheme that: comprises a fibula-implanted hollow tubular porous prosthesis with a bone plate and a porosity of 50-80% and a pore diameter of 500-700 mu m, wherein the shape of the bone plate is matched with the shape of a backbone.
The porous space structure of the porous prosthesis in the hollow tubular shape adopts a regular hexadecahedron diamond structure.
The shape of the tube wall of the hollow tubular porous prosthesis is similar to the shape of the bone in the defect area, and the thickness of the tube wall is 0.5mm-1.0mm larger than that of cortical bone.
The utility model is prepared by the following method:
1) preparation of personalized 3D printed prosthesis:
according to thin-layer CT scanning data of a patient, a hollow tubular porous prosthesis with a bone fracture plate, the porosity of which is 50% -80%, and the pore diameter of which is 500-700 mu m, implanted in a fibula is designed by combining an operation path and a bone cutting plane shape of a lesion part, prosthesis design data are guided into metal 3D printing equipment, titanium alloy powder is preheated at 650 ℃ at an electron beam current of 30mA and a scanning speed of 15000mm/s, and then the alloy powder is melted layer by layer at the electron beam current of 6mA and the scanning speed of 400mm/s to prepare the tubular porous titanium alloy prosthesis with the same expected shape;
2) surface active treatment of 3D printing tubular titanium alloy prosthesis
2-1) construction of micron-sized titanium oxide active surface coating
placing the prepared tubular porous titanium alloy prosthesis in an electrolyte with the concentration of calcium acetate of 0.2mol/L and the concentration of β sodium glycerophosphate of 0.04mol/L, performing micro-arc oxidation treatment on the tubular porous titanium alloy prosthesis by a pulse-direct current power supply under constant 350V voltage at the frequency of 200Hz and the duty ratio of 15 percent, and then performing treatment for 5min in a constant-temperature water bath to obtain a 3D printed tubular titanium alloy prosthesis with titanium oxide on the surface;
2-2) construction of a nano-barium titanate piezoelectrically active surface coating
Taking a 3D printing tubular titanium alloy prosthesis with titanium oxide on the surface as a titanium source, and synthesizing a barium titanate piezoelectric ceramic coating by in-situ autorotation: placing a 3D printing tubular titanium alloy prosthesis with titanium oxide on the surface in a Ba in a stainless steel high-pressure reaction kettle at 100-120 DEG C2+Ba (OH) at a concentration of 0.25mol/L2In the solution, the PH value is adjusted to 13 by NaOH, the reaction pressure is 0.7-1.1MPa, the reaction is carried out for 1-3 hours, and the dissolution of titanium oxide and the in-situ reaction of barium ions in the solution generate barium titanate on the surface of the 3D printing tubular titanium alloy prosthesis of titanium oxide.
The utility model has the advantages of it is following:
1. the fibula and the prosthesis are compounded, so that the strength of the bone defect reconstruction material is further improved, the early movement and the early stress are facilitated, the piezoelectric property of the piezoelectric ceramic is exerted by mechanical stimulation, the bone growth of the prosthesis is further promoted, the integration of the bone and the prosthesis is finally completed, and the early bone defect repair treatment is realized; 2. the designed prosthesis changes the single bone growth direction from outside to inside into two-way bone growth from outside to inside and from inside to outside after the traditional prosthesis is fixed, promotes the bone growth of the prosthesis, increases the stability of the prosthesis, and is beneficial to the early healing and the long-term stability of the bone defect; 3.3D printing the appearance of the personalized customized prosthesis to be matched with the height of the bone defect area, which is beneficial to the implementation of the operation and avoids the unequal lengths of the limbs on the two sides after reconstruction; 4. the whole layer of the wall of the prosthesis pipe is of a porous structure, so that the stress shielding effect is reduced; the pore structure is beneficial to implantation, and the stability of the interface with bone tissues is enhanced; 5. the surface active treatment improves the biocompatibility of the prosthesis, induces the growth of new bones and achieves good osseointegration effect; 6. the integrated bone fracture plate has high fit with the backbone, and the fixing reliability is improved. The auxiliary internal fixation is not needed, and the economy is better.
The further pore structure adopts a regular sixteen-surface diamond structure, so that the bearing capacity of the prosthesis is improved; the shape of the wall of the prosthesis pipe is similar to that of the backbone of the defect area, so that the prosthesis pipe is fit with the upper end and the lower end after being implanted; the thickness is 0.5mm-1.0mm larger than the cortical bone, so that the cortical bone has enough bearing capacity to avoid cutting the cortical bone; the bone fracture plate and the tubular prosthesis are in integrated printing of a composite structure, and the bonding strength is improved. The shape of the bone plate is matched with the height of the backbone so as to be beneficial to fixation. The prosthesis reserves a fibula implantation area, which is convenient for fibula implantation and blood vessel anastomosis.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a side view of FIG. 1;
fig. 3 is a left side view of fig. 1.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
Referring to fig. 1, 2, 3, the utility model discloses a porous titanium alloy prosthesis of tubular is printed to 3D for damaged big section bone of four limbs is 50% -80% including the porosity that has coaptation board 1, and the aperture is the cavity tubulose porous prosthesis 2 that 500 mu m-700 mu m's fibula was planted, coaptation board 1 shape agrees with diaphysis appearance, the porous space structure of porous prosthesis 2 of cavity tubulose form adopt regular hexadecahedron diamond structure, the porous prosthesis 2 pipe wall shape of cavity tubulose form is similar with defective region diaphysis, the thickness of pipe wall 3 is greater than cortex 0.5mm-1.0 mm.
The utility model is prepared by the following method:
1) preparation of tubular porous titanium alloy prosthesis through 3D printing
Referring to fig. 1 and 2, a hollow tubular porous prosthesis 2 with a bone fracture plate 1 is designed by adopting computer aided design software according to thin-layer CT scanning data of a patient and combining an operation path and a bone cutting plane shape of a lesion part, referring to fig. 3, the porous prosthesis 2 is designed into a hollow tubular bone grafting groove for facilitating fibula transplantation, a tube wall 3 is of a porous pore structure, the shape of the tube wall is similar to that of a skeleton in a defect region, the thickness of the tube wall is 0.5mm-1.0mm larger than that of the skeleton in the implant region, the pore structure is of a regular hexadecahedral diamond structure, the porosity is generally 50% -80%, the pore diameter range is 500 mu m-700 mu m, the bone grafting groove with a hollow structure is reserved on the tube wall, the operations such as fibula implantation, blood vessel anastomosis and the like are facilitated, the fibula implantation can realize bone ingrowth from the inner side of the tube wall to the outer side, the porous prosthesis, the prosthesis and the residual bone end can be locked without other auxiliary fixation, thereby simplifying the operation process and improving the economic benefit. The shape of the bone fracture plate is matched with the height of the backbone, so that the stability of fixation is enhanced, and loosening of internal fixation after operation is avoided. After the prosthesis design is finished, a finite element method is used for carrying out strength analysis, and the position of the bone plate screw setting position and the size of the bone grafting groove opening are optimized according to the analysis result. After the design is finished, data are led into printing equipment, titanium alloy powder (Ti-6Al-4V) is preheated at 650 ℃ by 30mA electron beam current and at the scanning speed of 15000mm/s, then the titanium alloy powder is melted layer by layer according to a set program under the control of a computer by 6mA electron beam current and at the scanning speed of 400 mm/s. And finally preparing the tubular porous titanium alloy prosthesis which is printed in a 3D mode and is consistent with the expected shape.
2) Surface active treatment of 3D printing tubular titanium alloy prosthesis
2-1) construction of micron-sized titanium oxide active surface coating
placing the prepared tubular porous titanium alloy prosthesis in an electrolyte with the concentration of calcium acetate of 0.2mol/L and the concentration of β sodium glycerophosphate of 0.04mol/L, performing micro-arc oxidation treatment on the tubular porous titanium alloy prosthesis by a pulse-direct current power supply under constant 350V voltage at the frequency of 200Hz and the duty ratio of 15 percent, and then performing treatment for 5min in a constant-temperature water bath to obtain a 3D printed tubular titanium alloy prosthesis with titanium oxide on the surface;
2-2) construction of a nano-barium titanate piezoelectrically active surface coating
Taking a 3D printing tubular titanium alloy prosthesis with titanium oxide on the surface as a titanium source, and synthesizing a barium titanate piezoelectric ceramic coating by in-situ autorotation: placing a 3D printing tubular titanium alloy prosthesis with titanium oxide on the surface in a Ba in a stainless steel high-pressure reaction kettle at 100-120 DEG C2+Ba (OH) at a concentration of 0.25mol/L2In the solution, the PH value is adjusted to 13 by NaOH, the reaction pressure is 0.7-1.1MPa, the reaction is carried out for 1-3 hours, and the dissolution of titanium oxide and the in-situ reaction of barium ions in the solution generate barium titanate on the surface of the 3D printing tubular titanium alloy prosthesis of titanium oxide.
The utility model discloses under the prerequisite that remains piezoceramics piezoelectricity characteristic, improved its and substrate material's joint strength greatly, solved the relatively poor problem of piezoceramics coating and substrate material combining ability for mechanics-electricity effect is promoting bone to grow into and is exert efficiency. Endows the porous titanium alloy prosthesis with certain piezoelectric performance, improves the bone induction growth capability of the porous titanium alloy prosthesis, and promotes the early formation of osseointegration.
Claims (3)
1. A3D prints porous titanium alloy prosthesis for big segment bone defect of four limbs which characterized in that: comprises a fibula-implanted hollow tubular porous prosthesis (2) with a bone plate (1) and a porosity of 50-80% and a pore diameter of 500-700 mu m, wherein the shape of the bone plate (1) is matched with the shape of a backbone.
2. The 3D printed tubular porous titanium alloy prosthesis for bone defects of large limbs according to claim 1, characterized in that: the porous space structure of the porous prosthesis (2) in the hollow tubular shape adopts a regular hexadecahedron diamond structure.
3. The 3D printed tubular porous titanium alloy prosthesis for bone defects of large limbs according to claim 1, characterized in that: the shape of the tube wall of the hollow tubular porous prosthesis (2) is similar to the shape of the bone in the defect area, and the thickness of the tube wall (3) is 0.5mm-1.0mm larger than that of cortical bone.
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| CN201921005835.0U CN210644251U (en) | 2019-07-01 | 2019-07-01 | A tubular porous titanium alloy prosthesis of 3D printing for big section bone defect of four limbs |
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| CN201921005835.0U CN210644251U (en) | 2019-07-01 | 2019-07-01 | A tubular porous titanium alloy prosthesis of 3D printing for big section bone defect of four limbs |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028035A (en) * | 2020-06-29 | 2022-02-11 | 北京力达康科技有限公司 | Fibula prosthesis based on 3D printing |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114028035A (en) * | 2020-06-29 | 2022-02-11 | 北京力达康科技有限公司 | Fibula prosthesis based on 3D printing |
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Effective date of registration: 20211025 Address after: 710000 Caotang Science and Technology Industrial Base, Xi'an High-tech Zone, Shaanxi Province Patentee after: WEIDU (XI'AN) BIOMEDICAL TECHNOLOGY Co.,Ltd. Address before: 710032 No. 169 West Changle Road, Shaanxi, Xi'an Patentee before: THE FOURTH MILITARY MEDICAL University |
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