CN110200727A - A kind of 3D printing tubular porous titanium prosthesis and preparation method thereof for four limbs large segmental bone defect - Google Patents
A kind of 3D printing tubular porous titanium prosthesis and preparation method thereof for four limbs large segmental bone defect Download PDFInfo
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- CN110200727A CN110200727A CN201910583939.8A CN201910583939A CN110200727A CN 110200727 A CN110200727 A CN 110200727A CN 201910583939 A CN201910583939 A CN 201910583939A CN 110200727 A CN110200727 A CN 110200727A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
- A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30108—Shapes
- A61F2002/30199—Three-dimensional shapes
- A61F2002/30224—Three-dimensional shapes cylindrical
- A61F2002/30235—Three-dimensional shapes cylindrical tubular, e.g. sleeves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
- A61F2002/30772—Apertures or holes, e.g. of circular cross section
- A61F2002/30784—Plurality of holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
- A61F2002/30953—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a remote computer network, e.g. Internet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2002/30985—Designing or manufacturing processes using three dimensional printing [3DP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
Abstract
A kind of 3D printing tubular porous titanium prosthesis and preparation method thereof for four limbs large segmental bone defect, according to patient's thin layer CT scan data, tubular porous titanium prosthesis is prepared in prosthetic designs data importing metal 3D printing equipment by the porous prosthese of the hollow tubular in conjunction with operation pathway and diseased region Osteotomy form Design with bone plate；The tubular porous titanium prosthesis of preparation is placed in the electrolyte of calcium acetate and β sodium glycero-phosphate and is reprocessed under water bath with thermostatic control to after tubular porous titanium prosthesis progress micro-arc oxidation treatment, the 3D printing tubulose titanium prosthesis that surface has titanium oxide is obtained；Place it in Ba (OH)2In solution, 3D printing tubulose titanium prosthesis Surface Creation barium titanate of the adjusting pH value to 13 reactions in titanium oxide.Surface-active-treatment of the present invention improves prosthese biocompatibility, induces new bone growth, reaches good Integrated implant effect；Integrated bone plate and backbone compatible degree are high, increase fixed reliability.It is not required to fixed in additional auxiliary.
Description
Technical field
The present invention relates to a kind of tubular porous titanium prosthesis, and in particular to a kind of 3D for four limbs large segmental bone defect is beaten
Print tubular porous titanium prosthesis and preparation method thereof.
Background technique
The reparation of large segmental bone defect caused by wound, tumour, infection etc. is current clinical common and stubborn problem.Allosome
Bone and the self fibula with blood vessel are most common bone defect restorative procedures.The advantages of allograph bone, is to be capable of providing bone
Amount and early stage support, but activation time is long, and the healing rate between receptor is low, and are easy infection.Self band vessel bone advantage exists
In bone collection living, healing rate is high, has certain anti-infection ability, however lacks since the thin Chang Buyi of caliber is individually used for leg bone
Damage, the incidence of secondary fracture is high in remodeling process after fibula healing.
The titanium alloy (Ti-6Al-4V) of clinical use is although have good mechanical strength at present, it is in clinical application
In the process, however it remains obvious shortcoming: 1, elasticity modulus (110GPa) is significantly larger than normal bone (cortex bone about 15GPa), generates
Stress shielding, leads to bone resorption, and bone-metal integration of interface is bad；2, titanium alloy is bio-inert material, to surrounding materials bone
No good stimulation is formed, leads to Bone Ingrowth quantity and to grow into speed slower.Body phase porous titanium alloy very good solution
This problem, is mainly shown as that internal structure is uniform, no sharp interface effect, and the pore structure of inside connection, is also new life
Bone tissue offer is good to grow into environment, and its strength of materials and modulus can be realized by the adjusting to porous structure parameter
It is matched with natural bone, therefore is a kind of ideal orthopaedics metal implant material.
3D printing technique is one kind based on mathematical model, constructs the technology of object by layer-by-layer printing.
By 3D printing technique, can obtain with the accurate matched porous titanium alloy Bone Defect Repari prosthese of bone defect, and pass through gap and knot
Structure adjustment, obtains and the close intensity of normal sclerotin；3D printing prosthese is not limited by bone defect shape simultaneously, it is not necessary to too much
Finishing residual sclerotin realizes individuation under the premise of more reservation sclerotin as far as possible, precisely, Exact Reconstruction treatment.3D printing is more
Hole titanium prosthesis has certain Bone Ingrowth ability, can combine closely with sclerotin, while by carrying out piezoelectricity pottery to prosthese
Porcelain surface modification treatment can further improve its Bone Ingrowth ability.Fibula and 3D printing porous titanium alloy prosthese are organically combined
Get up, to play the mechanical support of prosthese and the skeletonization of fibula and anti-infection effect, it can be achieved that mechanical complete with biology reconstruction
Beauty combines.
Summary of the invention
It is an object of the invention to overcome the shortcomings of current four limbs large segmental bone defect treatment method, provide a kind of for four
3D printing tubular porous titanium prosthesis of limb large segmental bone defect and preparation method thereof.
In order to achieve the above objectives, the technical solution adopted by the present invention is that:
1) preparation of personalized 3D printing prosthese:
According to patient's thin layer CT scan data, synthetism is had in conjunction with operation pathway and diseased region Osteotomy form Design
The porosity of plate is 50%-80%, the porous prosthese for the hollow tubular that the fibula that aperture is 500 μm -700 μm is implanted into, by prosthese
Design data imports metal 3D printing equipment, preheats titanium in the scanning speed of 650 DEG C of electronic beam currents with 30mA, 15000mm/s
Alloy powder, then with the electronic beam current of 6mA, the layer-by-layer melted alloy powder of the scanning speed of 400mm/s is prepared into and expected shape
The consistent tubular porous titanium prosthesis of shape；
2) 3D printing tubulose titanium prosthesis surface-active-treatment
2-1) construct micron order titanium oxide active surface coating
Using the tubular porous titanium prosthesis of preparation as working electrode, using constant voltage mode prepares coating: will prepare
Tubular porous titanium prosthesis be placed in calcium acetate concentration be 0.2mol/L, β phosphoglycerol na concn be 0.04mol/L electrolysis
It is 200Hz, duty ratio 15%, with pulse-DC power supply under constant 350V voltage to tubular porous titanium alloy in frequency in liquid
Prosthese reprocesses 5min under water bath with thermostatic control after carrying out micro-arc oxidation treatment, obtains the 3D printing tubulose titanium that surface has titanium oxide
Alloy prosthesis；
2-2) construct nanoscale barium titanate piezoelectric activity surface covering
Have the 3D printing tubulose titanium prosthesis of oxygen titanium oxide as titanium source, inverting synthesis of barium titanate in situ using surface
Piezoelectric Ceramic Coatings: in 100-120 DEG C of stainless steel autoclave, surface is had to the 3D printing tubulose titanium alloy of titanium oxide
Prosthese is placed in Ba2+Concentration is the Ba (OH) of 0.25mol/L2In solution, pH value is adjusted to 13 using NaOH, is in reaction pressure
0.7-1.1MPa reacts 1-3 hours, 3D printing tubulose of the barium ions reaction in-situ in titanium oxide dissolution and solution in titanium oxide
Titanium prosthesis Surface Creation barium titanate.
Include by the 3D printing tubular porous titanium prosthesis for being used for four limbs large segmental bone defect made from method made above
Porosity with bone plate is 50%-80%, the porous vacation for the hollow tubular that the fibula that aperture is 500 μm -700 μm is implanted into
Body, the synthetism plate shape are agreed with backbone shape.
The porous space structure of the porous prosthese of the hollow tubular form uses positive ten hexahedrons diamond lattic structure.
The porous prosthese tube wall shape and defective region backbone of the hollow tubular form are similar, and the thickness of tube wall is greater than bone
Cortex 0.5mm-1.0mm.
The invention has the following advantages that
1. fibula with prosthese is compound further improves the intensity of bone defect reconstruction biomaterials, be conducive to early ambulant, in early days by
Power, mechanical stimulation will play the piezoelectric property of piezoelectric ceramics, further promote the Bone Ingrowth of prosthese, be finally completed bone and prosthese
The treatment of early stage bone defect healing is realized in integration；2. prosthese designed by outer arrives interior bone uptake for traditional prosthesis is single after fixed
Direction becomes outer in, interior to outer two-way bone uptake, promotes the Bone Ingrowth of prosthese, increases the stability of prosthese, be conducive to bone
The immediate union of defect and stability at a specified future date；3.3D prints personalized customization prosthese shape and bone defect area high fit, is conducive to
Operation is implemented, and both limbs Length discrepancy after rebuilding is avoided；4. prosthese tube wall holostrome is porous structure, stress shielding effect is reduced
It answers；Pore structure is conducive to be implanted into, and enhances the stability with osseous tissue interface；5. surface-active-treatment improves prosthese biofacies
Capacitive induces new bone growth, reaches good Integrated implant effect；6. integrated bone plate and backbone compatible degree are high, increase and fix
Reliability.It is not required to fix in additional auxiliary, has more economy.
Further pore structure uses positive ten hexahedrons diamond lattic structure, improves prosthese load-bearing capacity；Prosthese tube wall
Shape and defective region backbone are similar, agree with conducive to after Using prosthesis with upper and lower side；Thickness is greater than cortical bone 0.5mm-1.0mm, really
Protecting, there is enough load-bearing capacities to avoid cutting cortical bone；Bone plate, which is that composite construction is integrated with cast prosthese, to be printed, and is improved
Bond strength.Synthetism plate shape and backbone high fit are in favor of fixation.Prosthese reserves fibula implantation region, convenient for fibula implantation and
Vascular anastomosis.
Detailed description of the invention
Fig. 1 is overall structure diagram of the invention；
Fig. 2 is the side view of Fig. 1；
Fig. 3 is the left view of Fig. 1.
Specific embodiment
The present invention is described in further details with reference to the accompanying drawing.
1) prepared by 3D printing tubular porous titanium prosthesis
Referring to Fig. 1,2, using computer aided design software, according to patient's thin layer CT scan data, in conjunction with operation pathway
And diseased region Osteotomy form, the porous prosthese 2 of hollow tubular of the design with bone plate 1, referring to Fig. 3, for convenient for calf
The porous prosthese 2 of bone collection is designed as the bone grafting slot of hollow tubular, and tube wall 3 is porous hole structure, shape and defective region backbone phase
Imitative, pipe thickness is greater than implantation region backbone 0.5mm-1.0mm, and pore structure is positive ten hexahedron diamond lattic structures, porosity
Generally 50%-80%, pore diameter range are 500 μm -700 μm, tube wall there are the bone grafting slot of hollow structure, convenient for fibula implantation and
The operation such as vascular anastomosis, implantation fibula can realize that, by the Bone Ingrowth of tube wall Inside To Outside, porous prosthese 2 is one with bone plate 1
Prosthese and residual epiphysis locking can be auxiliarily fixed without other while fixed fracture end, simplify hand by bodyization connection
Art process is increased economic efficiency.Synthetism plate shape and backbone high fit avoid in postoperative conducive to the stability that enhancing is fixed
It is fixed to loosen.After the completion of prosthetic designs, intensive analysis is carried out using finite element method, optimizes bone plate based on the analysis results and sets nail
Position, bone grafting channel opening size.Printing device is imported data to after the completion of design, in 650 DEG C of electronic beam currents with 30mA, with
The scanning speed of 15000mm/s preheats titanium alloy powder (Ti-6Al-4V), and then with the electronic beam current of 6mA, 400mm/s's is swept
It retouches speed to be controlled by computer, according to the layer-by-layer melted alloy powder of the program set.It is finally prepared to consistent with anticipated shape
3D printing tubular porous titanium prosthesis.
2) 3D printing tubulose titanium prosthesis surface-active-treatment
2-1) construct micron order titanium oxide active surface coating
Using the tubular porous titanium prosthesis of preparation as working electrode, using constant voltage mode prepares coating: will prepare
Tubular porous titanium prosthesis be placed in calcium acetate concentration be 0.2mol/L, β phosphoglycerol na concn be 0.04mol/L electrolysis
It is 200Hz, duty ratio 15%, with pulse-DC power supply under constant 350V voltage to tubular porous titanium alloy in frequency in liquid
Prosthese reprocesses 5min under water bath with thermostatic control after carrying out micro-arc oxidation treatment, obtains the 3D printing tubulose titanium that surface has titanium oxide
Alloy prosthesis；
2-2) construct nanoscale barium titanate piezoelectric activity surface covering
Have the 3D printing tubulose titanium prosthesis of oxygen titanium oxide as titanium source, inverting synthesis of barium titanate in situ using surface
Piezoelectric Ceramic Coatings: in 100-120 DEG C of stainless steel autoclave, surface is had to the 3D printing tubulose titanium alloy of titanium oxide
Prosthese is placed in Ba2+Concentration is the Ba (OH) of 0.25mol/L2In solution, pH value is adjusted to 13 using NaOH, is in reaction pressure
0.7-1.1MPa reacts 1-3 hours, 3D printing tubulose of the barium ions reaction in-situ in titanium oxide dissolution and solution in titanium oxide
Titanium prosthesis Surface Creation barium titanate.
By the 3D printing tubular porous titanium prosthesis for being used for four limbs large segmental bone defect made from preparation method of the invention
Including with bone plate 1 porosity be 50%-80%, aperture be 500 μm -700 μm fibula be implanted into hollow tubular it is more
Hole prosthese 2,1 shape of bone plate are agreed with backbone shape, the porous space of the porous prosthese 2 of the hollow tubular form
Structure uses positive ten hexahedrons diamond lattic structure, and the 2 tube wall shape of porous prosthese and defective region backbone of hollow tubular form are similar,
The thickness of tube wall 3 is greater than cortical bone 0.5mm-1.0mm.
For the present invention under the premise of retaining piezoelectric ceramics piezoelectric property, the combination for substantially increasing itself and base material is strong
Degree, solves the problems, such as that Piezoelectric Ceramic Coatings and base material binding ability are poor, so that mechanics-electrical effects are promoting bone long
Efficiency played in entering.It assigns porous titanium alloy prosthese certain piezoelectric property, improves its self-bone grafting and grow into ability, promote its morning
Phase forms Integrated implant.
Claims (4)
1. a kind of preparation method of the 3D printing tubular porous titanium prosthesis for four limbs large segmental bone defect, it is characterised in that packet
Include following steps:
1) preparation of personalized 3D printing prosthese:
According to patient's thin layer CT scan data, bone plate is had in conjunction with operation pathway and diseased region Osteotomy form Design
(1) porosity is 50%-80%, and the porous prosthese (2) for the hollow tubular that the fibula that aperture is 500 μm -700 μm is implanted into will
Prosthetic designs data import metal 3D printing equipment, pre- in the scanning speed of 650 DEG C of electronic beam currents with 30mA, 15000mm/s
Hot titanium alloy powder, then with the electronic beam current of 6mA, the layer-by-layer melted alloy powder of the scanning speed of 400mm/s be prepared into in advance
The consistent tubular porous titanium prosthesis of phase shape；
2) 3D printing tubulose titanium prosthesis surface-active-treatment
2-1) construct micron order titanium oxide active surface coating
Using the tubular porous titanium prosthesis of preparation as working electrode, using constant voltage mode prepares coating: by the pipe of preparation
It is 0.2mol/L that shape porous titanium alloy prosthese, which is placed in calcium acetate concentration, and β phosphoglycerol na concn is the electrolyte of 0.04mol/L
In, it is 200Hz in frequency, duty ratio 15% is false to tubular porous titanium alloy with pulse-DC power supply under constant 350V voltage
Body reprocesses 5min under water bath with thermostatic control after carrying out micro-arc oxidation treatment, obtains surface and closes with the 3D printing tubulose titanium of titanium oxide
Golden prosthese；
2-2) construct nanoscale barium titanate piezoelectric activity surface covering
Have the 3D printing tubulose titanium prosthesis of oxygen titanium oxide as titanium source, inverting synthesis of barium titanate piezoelectricity in situ using surface
Ceramic coating: in 100-120 DEG C of stainless steel autoclave, surface is had to the 3D printing tubulose titanium prosthesis of titanium oxide
It is placed in Ba2+Concentration is the Ba (OH) of 0.25mol/L2In solution, pH value is adjusted to 13 using NaOH, is 0.7- in reaction pressure
1.1MPa reacts 1-3 hours, and 3D printing tubulose titanium of the titanium oxide dissolution with the barium ions reaction in-situ in solution in titanium oxide closes
Golden prosthetic surface generates barium titanate.
2. a kind of preparation method as described in claim 1 3D printing tubular porous titanium obtained for being used for four limbs large segmental bone defect
Alloy prosthesis, it is characterised in that: the porosity including having bone plate (1) is 50%-80%, and aperture is 500 μm -700 μm
The porous prosthese (2) of the hollow tubular of fibula implantation, bone plate (1) shape are agreed with backbone shape.
3. the 3D printing tubular porous titanium prosthesis according to claim 2 for four limbs large segmental bone defect, feature
Be: the porous space structure of the porous prosthese (2) of the hollow tubular form uses positive ten hexahedrons diamond lattic structure.
4. the 3D printing tubular porous titanium prosthesis according to claim 2 for four limbs large segmental bone defect, feature
Be: porous prosthese (2) the tube wall shape and defective region backbone of the hollow tubular form are similar, and the thickness of tube wall (3) is big
In cortical bone 0.5mm-1.0mm.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113500207A (en) * | 2021-06-29 | 2021-10-15 | 华南理工大学 | Manufacturing method of conformal cooling mold for preparing self-supporting runner through metal 3D printing |
| CN115887069A (en) * | 2023-02-15 | 2023-04-04 | 吉林大学 | Femoral shaft multilayer composite bionic self-fixing prosthesis |
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