CN213433059U - Antibacterial peptide crystallization device - Google Patents
Antibacterial peptide crystallization device Download PDFInfo
- Publication number
- CN213433059U CN213433059U CN202021279356.0U CN202021279356U CN213433059U CN 213433059 U CN213433059 U CN 213433059U CN 202021279356 U CN202021279356 U CN 202021279356U CN 213433059 U CN213433059 U CN 213433059U
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- China
- Prior art keywords
- evaporating pot
- install
- puddler
- pot
- transmission case
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- Expired - Fee Related
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- 238000002425 crystallisation Methods 0.000 title claims abstract description 27
- 230000008025 crystallization Effects 0.000 title claims abstract description 27
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims description 22
- 238000001704 evaporation Methods 0.000 claims abstract description 63
- 238000009833 condensation Methods 0.000 claims abstract description 15
- 230000005494 condensation Effects 0.000 claims abstract description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 7
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 5
- 230000003115 biocidal effect Effects 0.000 claims abstract description 5
- 238000007789 sealing Methods 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 26
- 238000010438 heat treatment Methods 0.000 claims description 25
- 230000005540 biological transmission Effects 0.000 claims description 22
- 238000010030 laminating Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 abstract description 17
- 239000011550 stock solution Substances 0.000 description 18
- 101100298222 Caenorhabditis elegans pot-1 gene Proteins 0.000 description 11
- 101100298225 Caenorhabditis elegans pot-2 gene Proteins 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 102000044503 Antimicrobial Peptides Human genes 0.000 description 1
- 108700042778 Antimicrobial Peptides Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
Images
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- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
The utility model discloses an antibiotic peptide crystallization device, including evaporating pot and crystallizer, the evaporating pot with sealing connection has the vacuum tube between the crystallizer, install the vacuum pump on the vacuum tube, the feeding jar is installed at the evaporating pot top, be equipped with the scale on the feeding jar, feeding tank bottom is equipped with the inlet pipe, the inlet pipe runs through the top of evaporating pot, evaporating pot internally mounted has agitating unit, install the condensation plate in the crystallizer, the condensation plate will the crystallizing pot divide into crystallization chamber and condensation chamber, install the refrigerator in the condensation chamber. The utility model discloses an improve in the evaporating pot stoste and dissolve and evaporation rate, can further improve the efficiency of crystallization.
Description
Technical Field
The utility model relates to an antibacterial peptide crystallization device belongs to crystallization device technical field.
Background
The antibacterial peptide antigen refers to a basic polypeptide substance with antibacterial activity generated by induction in an insect body, has a molecular weight of about 2000-7000 and consists of 20-60 amino acid residues. Most of the active polypeptides have the characteristics of strong alkalinity, heat stability, broad-spectrum antibiosis and the like.
At present, all conventional antibiotics have corresponding drug-resistant pathogenic strains, and the drug resistance problem of pathogenic bacteria increasingly threatens the health of people. The search for new antibiotics is an effective way to solve the problem of drug resistance. The antibacterial peptide is considered to have wide application prospect in the medical industry because of high antibacterial activity, wide antibacterial spectrum, various types, wide selection range, difficult generation of resistance mutation of target strains and the like. The antibacterial peptide has broad-spectrum antibacterial activity, can quickly search and kill targets, and is a pure natural peptide in many cases, so that the antibacterial peptide is quickly used as a potential therapeutic drug. The therapeutic range of the antibacterial peptide is gram-negative bacteria, gram-positive bacteria, fungi, parasites, tumor cells and the like.
However, the existing antibacterial peptide crystallization dissolving tank has low working efficiency and slow crystallization and dissolving speeds; and the antibacterial peptide solution is adhered to the evaporating pot, which causes the waste of the stock solution.
Accordingly, those skilled in the art have been devoted to designing an antimicrobial peptide crystallization device.
SUMMERY OF THE UTILITY MODEL
The main object of the present invention is to provide an antibacterial peptide crystallizing device, which solves the above mentioned problems in the background art.
The purpose of the utility model can be achieved by adopting the following technical scheme:
the utility model provides an antibiotic peptide crystallization device, includes evaporating pot and crystallizer, the evaporating pot with sealing connection has the vacuum tube between the crystallizer, install the vacuum pump on the vacuum tube, the feeding jar is installed at the evaporating pot top, be equipped with the scale on the feeding jar, feeding tank bottom is equipped with the inlet pipe, the inlet pipe runs through the top of evaporating pot, evaporating pot internally mounted has agitating unit, install the condensation plate in the crystallizing pot, the condensation plate will the crystallizing pot divide into crystallization chamber and condensation chamber, install the refrigerator in the condensation chamber.
Preferably, the transmission case is installed at the top of evaporating pot, the second motor is installed at the transmission case top, the output of second motor runs through the top of transmission case and extends to the inside of transmission case, the action wheel is installed to the output of second motor, the meshing of action wheel one side has from the driving wheel, install first lead screw in the action wheel, install the second lead screw in the follow driving wheel, first lead screw with the bottom of second lead screw is fixed transmission bottom of the case portion.
Preferably, be equipped with the lifter plate in the transmission case, first lead screw with the second lead screw runs through respectively the lifter plate, the bottom center department of lifter plate installs first motor, the slider is installed to the both sides of lifter plate, seted up on the lateral wall of transmission case with slider assorted spout.
Preferably, the first lead screw and the second lead screw are opposite in thread.
Preferably, agitating unit includes the puddler, the output of first motor with the puddler is connected, the externally mounted of puddler has the stirring leaf, the puddler with the stirring leaf is hollow structure, the puddler with stirring leaf internally mounted has the second heater strip, install the heating piece on the puddler, the second heater strip with heating piece electric connection.
Preferably, the puddler externally mounted has the connecting rod, the connecting rod presses close to the scraper blade is installed to the one end of evaporating pot, the scraper blade laminating the inner wall of evaporating pot.
Preferably, the outer part of the evaporation tank is provided with a jacket, a first heating wire is arranged in the jacket, and the first heating wire is spirally arranged in the jacket.
The utility model has the advantages of:
1. the utility model discloses install first heater strip in the outside cover that presss from both sides of evaporating pot, design into the heliciform with first heater strip and heat around the evaporating pot, increase the heating area of the evaporating pot jar body, heat the jar body of evaporating pot, at the internally mounted second heater strip of puddler and stirring leaf simultaneously, heat stoste in the evaporating pot is inside, heat stoste through inside and outside simultaneously like this, improve the rate of heating of stoste, accelerate the dissolving evaporation of stoste, steam gets into behind the crystallizer along the vacuum tube, the refrigerator refrigeration, reach the saturation along with solution, antibiotic peptide is appeared and the crystallization, can further improve the efficiency of crystallization through the rate that improves the evaporating pot.
2. The utility model discloses install the scraper blade on the puddler of evaporating pot, drive first lead screw and second lead screw through the second motor and rotate, connect the lifter plate of first motor and reciprocate, and then the scraper blade on the drive puddler also can reciprocate in horizontal pivoted, and the inner wall laminating of scraper blade and evaporating pot just so scrapes the stoste on the evaporating pot inner wall when the scraper blade reciprocates, avoids extravagant.
Drawings
Fig. 1 is a cross-sectional view of the present invention;
fig. 2 is a sectional view of the lifting device of the present invention;
fig. 3 is a sectional view of the stirring device of the present invention.
In the figure: 1-an evaporation tank, 2-a crystallization tank, 3-a vacuum pipe, 4-a jacket, 5-a first heating wire, 6-a first motor, 7-a slide block, 8-a feeding tank, 9-a vacuum pump, 10-a condensation plate, 11-a refrigerator, 12-a chute, 13-a lifting plate, 14-a connecting rod, 15-a scraping plate, 16-a stirring rod, 17-a second heating wire, 18-a heating block, 19-a stirring blade, 20-a transmission box, 21-a second motor, 22-a driving wheel, 23-a driven wheel, 24-a first screw rod and 25-a second screw rod.
Detailed Description
In order to make the technical solutions of the present invention clearer and clearer for those skilled in the art, the present invention will be described in further detail with reference to the following embodiments and the accompanying drawings, but the embodiments of the present invention are not limited thereto.
As shown in fig. 1-3, the antibacterial peptide crystallization device provided by this embodiment, including evaporating pot 1 and crystallizing pot 2, sealing connection has vacuum tube 3 between evaporating pot 1 and crystallizing pot 2, install vacuum pump 9 on the vacuum tube 3, feeding pot 8 is installed at the top of evaporating pot 1, be equipped with the scale on the feeding pot 8, feeding pot 8 bottom is equipped with the inlet pipe, the inlet pipe runs through the top of evaporating pot 1, evaporating pot 1 internally mounted has agitating unit, install condensing plate 10 in the crystallizing pot 2, condensing plate 10 divides crystallizing pot 2 into crystallization chamber and condensation chamber, install refrigerator 11 in the condensation chamber.
When the device is used, the antibacterial peptide stock solution is poured into the evaporation tank 1 from the feeding tank 8, and the feeding tank 8 is provided with a graduated scale, so that the precipitation proportion of crystals can be known after the crystallization is finished; a stirring device is arranged in the evaporation tank 1, and can stir the stock solution to accelerate the dissolution of the stock solution; the former liquid dissolves the evaporation back in the evaporating pot 1 and pumps the steam in the evaporating pot 1 to crystallizing pot 2 through vacuum pump 9 and send out the crystallization intracavity, and refrigerator 11 blows in air conditioning the condensation intracavity and condenses steam, and the former liquid is the saturated condition this moment, and the crystallization is appeared, can further improve the efficiency of crystallization through the speed that improves the former liquid in the evaporating pot 1 and dissolve and evaporate.
In this embodiment, a transmission case 20 is installed at the top of an evaporation tank 1, a second motor 21 is installed at the top of the transmission case 20, an output end of the second motor 21 penetrates through the top of the transmission case 20 and extends to the inside of the transmission case 20, a driving wheel 22 is installed at an output end of the second motor 21, a driven wheel 23 is meshed on one side of the driving wheel 22, a first lead screw 24 is installed in the driving wheel 22, a second lead screw 25 is installed in the driven wheel 23, the bottoms of the first lead screw 24 and the second lead screw 25 are fixed at the bottom of the transmission case 20, the threads of the first lead screw 24 and the second lead screw 25 are opposite, a lifting plate 13 is arranged in the transmission case 20, the first lead screw 24 and the second lead screw 25 respectively penetrate through the lifting plate 13, a first motor 6 is installed at the center of the bottom of the lifting plate 13, sliders 7 are installed on two sides of the lifting plate 13.
The second motor 21 is started, the driving wheel 22 drives the driven wheel 23 to rotate, then the first screw rod 24 and the second screw rod 25 rotate in the same direction, the lifting plate 13 rises and falls, the sliding grooves 12 formed in the side wall of the transmission case 20 are matched with the sliding blocks 7 at the two ends of the lifting plate 13, the up-and-down stability of the lifting plate 13 is improved, the bottom of the lifting plate 13 is fixedly connected with the first motor 6 of the stirring device, and the lifting of the stirring device is further realized.
In this embodiment, agitating unit includes puddler 16, and the output of first motor 6 is connected with puddler 16, and the externally mounted of puddler 16 has stirring leaf 19, and puddler 16 and stirring leaf 19 are hollow structure, and puddler 16 and stirring leaf 19 internally mounted have second heater strip 17, install heating block 18 on the puddler 16, and second heater strip 17 and heating block 18 electric connection.
Through setting up puddler 16 and stirring leaf 19, can stir the stoste, accelerate dissolving of stoste to at puddler 16 and 19 internally mounted second heater strips 17 of stirring leaf, can follow that 1 is inside directly heats the stoste, improve stoste dissolving speed.
In this embodiment, a connecting rod 14 is mounted outside the stirring rod 16, a scraper 15 is mounted at one end of the connecting rod 14 close to the evaporation tank 1, and the scraper 15 is attached to the inner wall of the evaporation tank 1.
The scraper 15 attached to the inner wall of the evaporation tank 1 is arranged on the stirring rod 16, so that stock solution on the inner wall of the evaporation tank 1 can be scraped, and waste is prevented.
In this embodiment, a jacket 4 is installed outside the evaporation tank 1, a first heating wire 5 is installed in the jacket 4, and the first heating wire 5 is installed in the jacket 4 in a spiral shape.
The first heating in the jacket 4 is designed into a spiral shape, so that the contact area of the first heating wire 5 and the tank body of the evaporating tank 1 is increased, and the heating efficiency is improved.
The utility model discloses a theory of operation is: when the device is used, the antibacterial peptide stock solution is poured into the evaporation tank 1 from the feeding tank 8, and the feeding tank 8 is provided with a graduated scale, so that the precipitation proportion of crystals can be known after the crystallization is finished; the first heating wire 5 is started, the first heating wire 5 is designed to be spirally heated around the evaporating pot 1, the contact area between the first heating wire 5 and the pot body of the evaporating pot 1 can be increased, the heating speed is increased, the stock solution is heated from the outside of the stock solution, meanwhile, the second heating wire 17 is arranged in the stirring device in the evaporating pot 1, and the stock solution is heated in the stock solution, so that the stock solution is heated from the inside and the outside simultaneously, the heating speed of the stock solution is increased, and the dissolving and evaporation of the stock solution are accelerated; while heating, starting the first motor 6, wherein the first motor 6 drives the stirring rod 16 and the stirring blade 19 to rotate, so as to stir the stock solution in the evaporation tank 1 and accelerate the solution of the stock solution; after the antibacterial peptide stock solution is evaporated, steam is generated, the vacuum pump 9 pumps the steam into the crystallization cavity of the crystallization tank 2, the refrigerator 11 blows cold air into the condensation cavity to condense the steam, the stock solution is in a saturated state at the moment, crystals are separated out, and the crystallization efficiency can be further improved by increasing the dissolving and evaporating speeds of the stock solution in the evaporation tank 1.
Above, only the further embodiments of the present invention are shown, but the protection scope of the present invention is not limited thereto, and any person skilled in the art can replace or change the technical solution and the concept of the present invention within the protection scope of the present invention.
Claims (7)
1. The utility model provides an antibiotic peptide crystallization device, includes evaporating pot (1) and crystallizer (2), its characterized in that: evaporating pot (1) with sealing connection has vacuum tube (3) between crystallizer (2), install vacuum pump (9) on vacuum tube (3), feeding jar (8) are installed at evaporating pot (1) top, be equipped with the scale on feeding jar (8), feeding jar (8) bottom is equipped with the inlet pipe, the inlet pipe runs through the top of evaporating pot (1), evaporating pot (1) internally mounted has agitating unit, install condensing plate (10) in crystallizing pot (2), condensing plate (10) will crystallizing pot (2) divide into crystallization chamber and condensation chamber, refrigerator (11) are installed to the condensation intracavity.
2. The antibacterial peptide crystallizing device according to claim 1, wherein: transmission case (20) are installed at the top of evaporating pot (1), second motor (21) is installed at transmission case (20) top, the output of second motor (21) runs through the top of transmission case (20) and extends to the inside of transmission case (20), action wheel (22) are installed to the output of second motor (21), the meshing of action wheel (22) one side has from driving wheel (23), install first lead screw (24) in action wheel (22), install second lead screw (25) in from driving wheel (23), first lead screw (24) with the bottom of second lead screw (25) is fixed transmission case (20) bottom.
3. The antibacterial peptide crystallizing device according to claim 2, wherein: be equipped with lifter plate (13) in transmission case (20), first lead screw (24) with second lead screw (25) run through respectively lifter plate (13), the bottom center department of lifter plate (13) installs first motor (6), slider (7) are installed to the both sides of lifter plate (13), seted up on the lateral wall of transmission case (20) with slider (7) assorted spout (12).
4. The antibacterial peptide crystallizing device according to claim 2, wherein: the first screw rod (24) and the second screw rod (25) are opposite in thread.
5. The antibacterial peptide crystallizing device according to claim 3, wherein: agitating unit includes puddler (16), the output of first motor (6) with puddler (16) are connected, the externally mounted of puddler (16) has stirring leaf (19), puddler (16) with stirring leaf (19) are hollow structure, puddler (16) with stirring leaf (19) internally mounted has second heater strip (17), install heating block (18) on puddler (16), second heater strip (17) with heating block (18) electric connection.
6. The antibacterial peptide crystallizing device according to claim 5, wherein: puddler (16) externally mounted has connecting rod (14), connecting rod (14) are pressed close to scraper blade (15) are installed to the one end of evaporating pot (1), scraper blade (15) laminating the inner wall of evaporating pot (1).
7. The antibacterial peptide crystallizing device according to claim 1, wherein: the outer mounting of evaporating pot (1) has clamp cover (4), install first heater strip (5) in clamp cover (4), first heater strip (5) are the heliciform and install in clamp cover (4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021279356.0U CN213433059U (en) | 2020-07-02 | 2020-07-02 | Antibacterial peptide crystallization device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021279356.0U CN213433059U (en) | 2020-07-02 | 2020-07-02 | Antibacterial peptide crystallization device |
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| Publication Number | Publication Date |
|---|---|
| CN213433059U true CN213433059U (en) | 2021-06-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202021279356.0U Expired - Fee Related CN213433059U (en) | 2020-07-02 | 2020-07-02 | Antibacterial peptide crystallization device |
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| CN (1) | CN213433059U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116102110A (en) * | 2023-04-12 | 2023-05-12 | 烟台优泰环保科技有限公司 | Crystallization treatment device based on industrial sewage reuse |
| CN117018994A (en) * | 2023-10-07 | 2023-11-10 | 山东赛高新材料有限公司 | Heating device for adhesive processing |
| CN117326735A (en) * | 2023-10-11 | 2024-01-02 | 河北乐恒节能设备有限公司 | Sodium sulfate solution recovery device and process |
-
2020
- 2020-07-02 CN CN202021279356.0U patent/CN213433059U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116102110A (en) * | 2023-04-12 | 2023-05-12 | 烟台优泰环保科技有限公司 | Crystallization treatment device based on industrial sewage reuse |
| CN116102110B (en) * | 2023-04-12 | 2023-06-16 | 烟台优泰环保科技有限公司 | Crystallization treatment device based on industrial sewage reuse |
| CN117018994A (en) * | 2023-10-07 | 2023-11-10 | 山东赛高新材料有限公司 | Heating device for adhesive processing |
| CN117018994B (en) * | 2023-10-07 | 2024-01-05 | 山东赛高新材料有限公司 | Heating device for adhesive processing |
| CN117326735A (en) * | 2023-10-11 | 2024-01-02 | 河北乐恒节能设备有限公司 | Sodium sulfate solution recovery device and process |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20210615 |
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| CF01 | Termination of patent right due to non-payment of annual fee |