CN108837548A - A kind of medical science exploitation drug evaporated crystallization device - Google Patents

A kind of medical science exploitation drug evaporated crystallization device Download PDF

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Publication number
CN108837548A
CN108837548A CN201810662248.2A CN201810662248A CN108837548A CN 108837548 A CN108837548 A CN 108837548A CN 201810662248 A CN201810662248 A CN 201810662248A CN 108837548 A CN108837548 A CN 108837548A
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CN
China
Prior art keywords
wall
welded
cooling
heating compartment
bolted
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Pending
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CN201810662248.2A
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Chinese (zh)
Inventor
郜佩环
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Zhengzhou Renhong Pharmaceutical Technology Co Ltd
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Zhengzhou Renhong Pharmaceutical Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Zhengzhou Renhong Pharmaceutical Technology Co Ltd filed Critical Zhengzhou Renhong Pharmaceutical Technology Co Ltd
Priority to CN201810662248.2A priority Critical patent/CN108837548A/en
Publication of CN108837548A publication Critical patent/CN108837548A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0018Evaporation of components of the mixture to be separated
    • B01D9/0022Evaporation of components of the mixture to be separated by reducing pressure
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D9/0018Evaporation of components of the mixture to be separated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D9/00Crystallisation
    • B01D2009/0086Processes or apparatus therefor

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  • Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)

Abstract

The invention belongs to drug processing technique fields, especially a kind of medical science exploitation drug evaporated crystallization device, it is relatively simple for existing apparatus structure, the slow problem of crystallized medicine rate, now propose following scheme, including heating compartment and cooling outer case, the heating compartment side inner wall top is plugged with feed pipe, and feed pipe is equipped with the first solenoid valve, the heating compartment top exterior walls have been bolted first motor, and first motor output shaft passes through heating compartment top inner wall and is welded with the first transmission shaft, first transmission shaft side outer wall is welded with the stirring rod of equidistant annular spread, and first transmission shaft far from one end of first motor be welded with helical blade.The present invention can first improve the concentration after drug solution heating, then be cooled down, so improve drug it is cooling when precipitation rate, additionally improve the speed of crystallization scraping, discharge rapider, also increase the intelligent operation of device, save manpower.

Description

A kind of medical science exploitation drug evaporated crystallization device
Technical field
The present invention relates to technical field of medical equipment more particularly to a kind of medical science exploitation drug evaporative crystallization to fill It sets.
Background technique
Crystallizing tank is the crystallizer that interlayer domestic demand chilled water or chilled water sharply cool down after material hybrid reaction at present, Its key link is that the size of interlayer area, the structure type and material outlet form of blender, the interior high-precision of tank body polish, And the requirement without dead angle is cleaned in tank body to meet technique use condition.
Through retrieving, Chinese patent grant number is the patent of CN203494210U, discloses a kind of knot for being used to prepare drug Brilliant tank, including tank body, agitating paddle, the motor being connected with agitating paddle, the agitating paddle stirs in tank body under the drive of the motor Dynamic reaction raw materials, wherein the crystallizing tank further comprises waste material device for trapping, for retaining the impurity of crystallized medicine tank mouth, Its tank mouth for being installed on crystallizing tank, and be sheathed on agitating paddle.It is installed with waste material device for trapping at tank mouth, is sheathed on stirring It on paddle, slots opposite with tank mouth, continues the impurity or close fallen from tank mouth in rotation process for retaining simultaneously containing agitating paddle Sealing.It is had the following disadvantages in above-mentioned patent:Structure is relatively simple, and crystallized medicine rate is slow, and above-mentioned patent not can solve this Therefore class problem needs a kind of medical science exploitation drug evaporated crystallization device.
Summary of the invention
Technology that is simple based on a kind of crystallizing tank design structure for being used to prepare drug, having a single function, discharge inconvenience is asked Topic, the invention proposes a kind of medical science exploitation drug evaporated crystallization devices.
A kind of medical science exploitation drug evaporated crystallization device proposed by the present invention, including heating compartment and cooling outer container Body, the heating compartment side inner wall top is plugged with feed pipe, and feed pipe is equipped with the first solenoid valve, the heating compartment Top exterior walls have been bolted first motor, and first motor output shaft passes through heating compartment top inner wall and is welded with first Transmission shaft, first transmission shaft side outer wall is welded with the stirring rod of equidistant annular spread, and the first transmission shaft is far from One end of one motor is welded with helical blade, and heating compartment side inner wall is bolted the electricity equidistantly distributed and adds Heat pipe, and heating compartment top exterior walls side is plugged with exhaust pipe, the heating compartment side outer wall bottom end is welded with fixed plate, And fixed plate top exterior walls have been bolted infusion pump, the infusion pump water inlet outer wall is welded with water inlet pipe, it is described into Water pipe is plugged on the inner wall of heating compartment side far from one end of infusion pump, and the infusion pump water outlet outer wall is welded with water outlet Pipe, and outlet pipe is equipped with the one end of outlet pipe described in second solenoid valve far from infusion pump and is plugged on cooling across cooling outer case On the inner wall of internal box side.
Preferably, the cooling outer case side inner wall is welded with multiple fixed links, and one end of fixed link is welded with together One cooling internal box.
Preferably, heating compartment top exterior walls side has been bolted air blower, and blower inlet with Exhaust pipe connection, exhaust pipe side inner wall are welded with the first filter screen.
Preferably, the cooling outer case top exterior walls have been bolted the second motor, and the second motor output shaft It is welded with second driving shaft across cooling internal box top inner wall, second driving shaft side outer wall is welded with multiple equidistant annulars The fixed column of distribution, the bottom end of second driving shaft are welded with the second helical blade, and one end of fixed column is welded with the same scraper plate, Cooling outer case and cooling internal box top exterior walls side are plugged with the same vacuum tube, and vacuum tube side inner wall is welded with second Filter screen, vacuum tube are connected with vacuum generator far from one end of cooling outer case, and vacuum generator is outer by bolt and cooling Cabinet is fixed, and gap is welded with spiral stream guidance pipe between cooling outer case and cooling internal box, and spiral stream guidance tube bottom end passes through cold But outer case is connected with water pump, and cooling outer case top exterior walls are welded with support frame, and support frame top exterior walls side passes through bolt It is fixed with water pump.
Preferably, support frame as described above top exterior walls side is welded with cooling water tank, and pump outlet outer wall is welded with company Adapter tube, connecting tube are plugged on the inner wall of cooling water tank side far from one end of water pump, and spiral stream guidance tube top end is plugged on cooling water On the inner wall top of case side, cooling water tank top exterior walls side is equipped with inlet valve.
Preferably, the cooling outer case and cooling internal box bottom outer wall are provided with the identical circular through hole of specification, and two A circular through hole inner wall is welded with the same discharge bucket, and discharge bucket bottom interior wall is threaded with discharge gate.
Preferably, heating compartment side outer wall has been bolted control cabinet, and control cabinet side inner wall passes through Bolt is fixed with processor, and heating compartment side outer wall is provided with rectangle mounting hole, and rectangle inner wall of the hole installing has been bolted Observation window.
Preferably, the heating compartment side inner wall top and top inner wall have been bolted temperature sensor respectively And water level sensor, and temperature sensor and water level sensor signal output end are connected by signal wire and processor signal input terminal It connects.
Preferably, the cooling internal box top inner wall has been bolted concentration sensor, and concentration sensor is believed Number output end is connect by signal wire with processor signal input terminal.
Preferably, first solenoid valve, electric heating tube, first motor, air blower, infusion pump, second solenoid valve, water Pump, the second motor and vacuum generator pass through conducting wire and are connected with switch, and switch and exported by signal wire and processor signal End connection.
Having the beneficial effect that in the present invention:
1, stirring rod on the first transmission shaft is able to drive by the setting of first motor and the first helical blade rotates, allow drug Solution seethe up and down, accelerates the rapid evaporation of drug solution, the concentration after improving drug solution heating, and then improves Precipitation rate when drug is cooling.
2, air between cooling internal box and cooling outer case can be cooled down rapidly by the setting of spiral stream guidance pipe, is promoted The high concentration drug solution conveyed into infusion pump is quickly cooled down to be precipitated and be bonded on cooling internal box inner wall, improves drug and is precipitated Working efficiency and drug crystal the uniformity.
3, the scraper plate being able to drive on second driving shaft 3 by the setting of the second motor 27 will be tied on cooling internal box inner wall Brilliant drug scrapes, then is quickly exported crystallized medicine object from discharge bucket by the rotation of the second helical blade, improves crystallization and scrapes The speed taken discharges rapider.
4, can be when strength of fluid decline by the setting of vacuum generator, signal is transmitted to vacuum and sent out by concentration sensor Raw device, vacuum generator generate vacuum in cooling internal box, and liquid is added in cooling internal box from outlet pipe;Concentration is high When concentration sensor defines value, vacuum generator stops vacuum, and charging stops, and improves device repeated work number, increases The intelligent operation of device saves manpower.
Detailed description of the invention
Fig. 1 is the schematic cross-sectional view that drug evaporated crystallization device is used in a kind of medical science exploitation proposed by the present invention;
Fig. 2 is the heating compartment structural schematic diagram that drug evaporated crystallization device is used in a kind of medical science exploitation proposed by the present invention;
Fig. 3 is that a kind of cooling outer case sectional structure of medical science exploitation drug evaporated crystallization device proposed by the present invention shows It is intended to;
Fig. 4 is the second driving shaft structural representation that drug evaporated crystallization device is used in a kind of medical science exploitation proposed by the present invention Figure;
Fig. 5 is that a kind of cooling outer case front view structure of medical science exploitation drug evaporated crystallization device proposed by the present invention is shown It is intended to.
In figure:1 heating compartment, 2 first solenoid valves, 3 feed pipes, 4 first transmission shafts, 5 stirring rod, 6 first motors, 7 rows Tracheae, 8 first filter screens, 9 air blowers, 10 water level sensors, 11 electric heating tubes, 12 temperature sensors, 13 heat keepers, 14 spirals Blade, 15 water inlet pipes, 16 fixed plates, 17 infusion pumps, 18 outlet pipes, 19 second solenoid valves, 20 cooling outer cases, 21 water pumps, 22 Cooling water tank, 23 inlet valves, 24 observation windows, 25 control cabinets, 26 cooling internal box, 27 second motors, 28 vacuum tubes, 29 vacuum hair Raw device, 30 second filter screens, 31 spiral stream guidance pipes, 32 scraper plates, 33 fixed columns, 34 second driving shafts, 35 support frames, 36 dischargings Bucket, 37 second helical blades.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Referring to Fig.1-5, a kind of medical science exploitation drug evaporated crystallization device, including heating compartment 1 and cooling outer container Body 20,1 side inner wall top of heating compartment is plugged with feed pipe 3, and feed pipe 3 is equipped with the first solenoid valve 2, heating compartment 1 Top exterior walls have been bolted first motor 6, and 6 output shaft of first motor passes through 1 top inner wall of heating compartment and is welded with First transmission shaft 4,4 side outer wall of the first transmission shaft is welded with the stirring rod 5 of equidistant annular spread, and the first transmission shaft 4 is remote One end from first motor 6 is welded with helical blade 14, and 1 side inner wall of heating compartment, which is bolted, to be equidistantly distributed Electric heating tube 11, and 1 top exterior walls side of heating compartment is plugged with exhaust pipe 7,1 side outer wall bottom end of heating compartment is welded with solid Fixed board 16, and 16 top exterior walls of fixed plate have been bolted infusion pump 17,17 water inlet outer wall of infusion pump is welded with into water Pipe 15, water inlet pipe 15 are plugged on 1 side inner wall of heating compartment far from one end of infusion pump 17, the weldering of 17 water outlet outer wall of infusion pump It is connected to outlet pipe 18, and outlet pipe 18 is equipped with 19 outlet pipe 18 of second solenoid valve and passes through outside cooling far from one end of infusion pump 17 Cabinet 20 is plugged on cooling 26 side inner wall of internal box.
Cooling 20 side inner wall of outer case is welded with multiple fixed links in the present invention, and one end of fixed link be welded with it is same A cooling internal box 26,1 top exterior walls side of heating compartment have been bolted air blower 9, and 9 air inlet of air blower and row Tracheae 7 connects, and 7 side inner wall of exhaust pipe is welded with the first filter screen 8, and cooling 20 top exterior walls of outer case have been bolted Second motor 27, and 27 output shaft of the second motor passes through cooling 26 top inner wall of internal box and is welded with second driving shaft 34, second 34 side outer wall of transmission shaft is welded with the fixed column 33 of multiple equidistant annular spreads, and the bottom end of second driving shaft 34 is welded with Two helical blades 37, one end of fixed column 33 are welded with the same scraper plate 32, cooling outer case 20 and cooling 26 top of internal box Outer wall side is plugged with the same vacuum tube 28, and 28 side inner wall of vacuum tube is welded with the second filter screen 30, and vacuum tube 28 is separate One end of cooling outer case 20 is connected with vacuum generator 29, and vacuum generator 29 is fixed by bolt and cooling outer case 20, Gap is welded with spiral stream guidance pipe 31 between cooling outer case 20 and cooling internal box 26, and 31 bottom end of spiral stream guidance pipe passes through cooling Outer case 20 is connected with water pump 21, and cooling 20 top exterior walls of outer case are welded with support frame 35, and support frame top exterior walls side is logical It crosses bolt and water pump 21 is fixed, 35 top exterior walls side of support frame is welded with cooling water tank 22, and 21 water outlet outer wall of water pump welds It is connected to connecting tube, connecting tube is plugged on 22 side inner wall of cooling water tank far from one end of water pump 21,31 top of spiral stream guidance pipe It is plugged on 22 side inner wall top of cooling water tank, 22 top exterior walls side of cooling water tank is equipped with inlet valve 23, cooling outer case 20 are provided with the identical circular through hole of specification with cooling 26 bottom outer wall of internal box, and two circular through hole inner walls be welded with it is same Discharge bucket 36,36 bottom interior wall of discharge bucket are threaded with discharge gate, and 1 side outer wall of heating compartment has been bolted control Case 25 processed, and 25 side inner wall of control cabinet has been bolted processor, 1 side outer wall of heating compartment is provided with rectangle installation Hole, rectangle inner wall of the hole installing have been bolted observation window 24, and 1 side inner wall top of heating compartment and top inner wall are led to respectively It crosses bolt and is fixed with temperature sensor 12 and water level sensor 10, and 10 signal output end of temperature sensor 12 and water level sensor It is connect by signal wire with processor signal input terminal, cooling 26 top inner wall of internal box has been bolted concentration sensing Device, and concentration sensor signal output end is connect by signal wire with processor signal input terminal, the first solenoid valve 2, electric heating Pipe 11, first motor 6, air blower 9, infusion pump 17, second solenoid valve 19, water pump 21, the second motor 27 and vacuum generator 29 Switch is connected with by conducting wire, and switchs and is connect by signal wire with processor signal output end, processor model is ARM10TDMI。
In use, first motor 6 drives stirring rod 5 and the rotation of the first helical blade 14 on the first transmission shaft 4, drug is allowed Solution seethe up and down, accelerates the rapid evaporation of drug solution, the concentration after improving drug solution heating, spiral stream guidance pipe 31 cool down rapidly air between cooling internal box 26 and cooling outer case 20, the high concentration drug for promoting infusion pump 17 to convey Solution is quickly cooled down to be precipitated and be bonded on cooling 26 inner wall of internal box, and the second motor 27 drives the scraper plate 32 on second driving shaft 34 Crystallization drug will scrape on cooling 26 inner wall of internal box, then by the rotation of the second helical blade 37 by crystallized medicine object from discharging Bucket 36 quickly export, improve crystallization scraping speed, discharge it is rapider, vacuum generator 29 strength of fluid decline when, Signal is transmitted to vacuum generator 29 by concentration sensor, and vacuum generator 29 generates vacuum, high concentration medicine in cooling internal box Liquid is added in cooling internal box 26 from outlet pipe 18;When concentration defines value higher than concentration sensor, vacuum generator stops true Sky, charging stop, and continue to crystallize work.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (10)

1. a kind of medical science exploitation drug evaporated crystallization device, including heating compartment(1)With cooling outer case(20), special Sign is, the heating compartment(1)Side inner wall top is plugged with feed pipe(3), and feed pipe(3)It is equipped with the first solenoid valve (2), the heating compartment(1)Top exterior walls have been bolted first motor(6), and first motor(6)Output shaft passes through Heating compartment(1)Top inner wall is welded with the first transmission shaft(4), first transmission shaft(4)Side outer wall is welded with equidistant The stirring rod of annular spread(5), and the first transmission shaft(4)Far from first motor(6)One end be welded with helical blade(14), institute State heating compartment(1)Side inner wall is bolted the electric heating tube equidistantly distributed(11), and heating compartment(1)Top Outer wall side is plugged with exhaust pipe(7), the heating compartment(1)Side outer wall bottom end is welded with fixed plate(16), and fixed plate (16)Top exterior walls have been bolted infusion pump(17), the infusion pump(17)Water inlet outer wall is welded with water inlet pipe (15), the water inlet pipe(15)Far from infusion pump(17)One end be plugged on heating compartment(1)On the inner wall of side, the infusion pump (17)Water outlet outer wall is welded with outlet pipe(18), and outlet pipe(18)It is equipped with second solenoid valve(19)The outlet pipe(18) Far from infusion pump(17)One end pass through cooling outer case(20)It is plugged on cooling internal box(26)On the inner wall of side.
2. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described cold But outer case(20)Side inner wall is welded with multiple fixed links, and one end of fixed link is welded with the same cooling internal box (26).
3. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described to add Hot tank body(1)Top exterior walls side has been bolted air blower(9), and air blower(9)Air inlet and exhaust pipe(7)Even It connects, exhaust pipe(7)Side inner wall is welded with the first filter screen(8).
4. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described cold But outer case(20)Top exterior walls have been bolted the second motor(27), and the second motor(27)Output shaft passes through in cooling Cabinet(26)Top inner wall is welded with second driving shaft(34), second driving shaft(34)Side outer wall is welded with multiple equidistant rings The fixed column of shape distribution(33), second driving shaft(34)Bottom end be welded with the second helical blade(37), fixed column(33)One End is welded with the same scraper plate(32), cooling outer case(20)With cooling internal box(26)Top exterior walls side is plugged with same Vacuum tube(28), vacuum tube(28)Side inner wall is welded with the second filter screen(30), vacuum tube(28)Far from cooling outer case (20)One end be connected with vacuum generator(29), vacuum generator(29)Pass through bolt and cooling outer case(20)It is fixed, it is cold But outer case(20)With cooling internal box(26)Between gap be welded with spiral stream guidance pipe(31), spiral stream guidance pipe(31)It wears bottom end Supercooling outer case(20)It is connected with water pump(21), cooling outer case(20)Top exterior walls are welded with support frame(35), support frame Top exterior walls side passes through bolt and water pump(21)It is fixed.
5. a kind of medical science exploitation drug evaporated crystallization device according to claim 4, which is characterized in that the branch Support(35)Top exterior walls side is welded with cooling water tank(22), and water pump(21)Water outlet outer wall is welded with connecting tube, connection It manages far from water pump(21)One end be plugged on cooling water tank(22)On the inner wall of side, spiral stream guidance pipe(31)Top is plugged on cooling Water tank(22)On the inner wall top of side, cooling water tank(22)Top exterior walls side is equipped with inlet valve(23).
6. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described cold But outer case(20)With cooling internal box(26)Bottom outer wall is provided with the identical circular through hole of specification, and two circular through hole inner walls It is welded with the same discharge bucket(36), discharge bucket(36)Bottom interior wall is threaded with discharge gate.
7. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described to add Hot tank body(1)Side outer wall has been bolted control cabinet(25), and control cabinet(25)Side inner wall has been bolted Processor, heating compartment(1)Side outer wall is provided with rectangle mounting hole, and rectangle inner wall of the hole installing has been bolted observation window (24).
8. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described to add Hot tank body(1)Side inner wall top and top inner wall have been bolted temperature sensor respectively(12)And water level sensor (10), and temperature sensor(12)And water level sensor(10)Signal output end is connected by signal wire and processor signal input terminal It connects.
9. a kind of medical science exploitation drug evaporated crystallization device according to claim 4, which is characterized in that described cold But internal box(26)Top inner wall has been bolted concentration sensor, and concentration sensor signal output end passes through signal wire It is connect with processor signal input terminal.
10. a kind of medical science exploitation drug evaporated crystallization device according to claim 1, which is characterized in that described First solenoid valve(2), electric heating tube(11), first motor(6), air blower(9), infusion pump(17), second solenoid valve(19), water Pump(21), the second motor(27)And vacuum generator(29)Switch is connected with by conducting wire, and is switched through signal wire and place Manage the connection of device signal output end.
CN201810662248.2A 2018-06-25 2018-06-25 A kind of medical science exploitation drug evaporated crystallization device Pending CN108837548A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020228550A1 (en) * 2019-05-12 2020-11-19 江苏嘉泰蒸发设备股份有限公司 Evaporative crystallization device convenient for discharging
CN112237751A (en) * 2019-07-16 2021-01-19 合众思(北京)环境工程有限公司 MVR evaporation crystallization device with automatic crystal scale processing function

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845916A (en) * 2014-03-19 2014-06-11 河北美邦工程科技有限公司 System and technology for continuously concentrating and collecting crystals
CN204543582U (en) * 2015-01-25 2015-08-12 宁波大学 A kind of Electromagnetic Heating concentration tank
CN205435038U (en) * 2015-12-30 2016-08-10 天津滨茂科技有限公司 Pharmaceutical crystallization device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103845916A (en) * 2014-03-19 2014-06-11 河北美邦工程科技有限公司 System and technology for continuously concentrating and collecting crystals
CN204543582U (en) * 2015-01-25 2015-08-12 宁波大学 A kind of Electromagnetic Heating concentration tank
CN205435038U (en) * 2015-12-30 2016-08-10 天津滨茂科技有限公司 Pharmaceutical crystallization device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020228550A1 (en) * 2019-05-12 2020-11-19 江苏嘉泰蒸发设备股份有限公司 Evaporative crystallization device convenient for discharging
CN112237751A (en) * 2019-07-16 2021-01-19 合众思(北京)环境工程有限公司 MVR evaporation crystallization device with automatic crystal scale processing function

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