CN209778712U - Antibacterial peptide crystallization device - Google Patents
Antibacterial peptide crystallization device Download PDFInfo
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- CN209778712U CN209778712U CN201920573158.6U CN201920573158U CN209778712U CN 209778712 U CN209778712 U CN 209778712U CN 201920573158 U CN201920573158 U CN 201920573158U CN 209778712 U CN209778712 U CN 209778712U
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Abstract
The utility model discloses an antibiotic peptide crystallization device, its characterized in that: the device comprises an evaporation tank and a crystallization tank, wherein a feed inlet is formed in the top of the evaporation tank, a first stirring mechanism is arranged in the evaporation tank and comprises a first stirring motor and a first stirring shaft, the output end of the first stirring motor penetrates through the bottom of the evaporation tank and is connected with the first stirring shaft, and the first stirring shaft extends from the bottom of the evaporation tank to the top of the evaporation tank; the inside of the evaporation tank is separated by a heat conduction plate to form a heating layer, and a heating part is arranged in the heating layer; the evaporation tank is communicated with the crystallization tank through a vapor pipe, and an air exhaust part is connected to the evaporation pipe; the crystallizer is characterized in that a condensing plate is arranged inside the crystallizer to divide the crystallizer into a crystallization cavity and a condensation cavity, and the condensation cavity is connected with an external refrigerator through a condensing pipe. The utility model discloses having going on that antibiotic peptide crystallization process can be continuous, crystallization efficiency is high, and solution can crystallize completely.
Description
Technical Field
The utility model relates to an antibacterial peptide apparatus for producing field, concretely relates to antibacterial peptide crystallization device.
Background
At present, all conventional antibiotics have corresponding drug-resistant pathogenic strains, and the drug resistance problem of pathogenic bacteria increasingly threatens the health of people. The search for new antibiotics is an effective way to solve the problem of drug resistance. The antibacterial peptide is considered to have wide application prospect in the medical industry because of high antibacterial activity, wide antibacterial spectrum, various types, wide selection range, difficult generation of resistance mutation of target strains and the like. The antibacterial peptide has broad-spectrum antibacterial activity and strong killing effect on bacteria, and particularly the killing effect on some drug-resistant pathogenic bacteria draws more attention.
abuse of traditional antibiotics causes various drug-resistant strains to appear clinically, and the human health is seriously harmed. In the process of competing with pathogenic bacteria variation, antibacterial peptides from various sources in nature become a new hope for developing novel anti-infective drugs, but the understanding and research of antibacterial peptides still focus on the effect of directly killing bacteria.
Chinese patent, application No. 201520644969.2, specifically discloses a novel antibacterial peptide crystallization and dissolution tank, which comprises a tank body, wherein the upper end of the tank body is provided with a feed inlet, the bottom end of the tank body is provided with a discharge outlet, and a stirring device is arranged in the tank body; the discharge port is internally provided with a filtering device and a valve. The antibacterial peptide of the device is slow in crystallization and cannot be crystallized continuously.
SUMMERY OF THE UTILITY MODEL
In view of the above, there is a need to provide an antimicrobial peptide crystallization device, which is used to solve the technical problems of the prior art that the antimicrobial peptide is slow to crystallize and cannot be crystallized continuously.
In order to solve the technical problem, the utility model discloses the technical scheme who takes is:
An antibacterial peptide crystallization device comprises an evaporation tank and a crystallization tank, wherein a feed inlet is formed in the top of the evaporation tank, a first stirring mechanism is arranged inside the evaporation tank and comprises a first stirring motor and a first stirring shaft, the output end of the first stirring motor penetrates through the bottom of the evaporation tank and is connected with the first stirring shaft, and the first stirring shaft extends from the bottom of the evaporation tank to the top of the evaporation tank; the inside of the evaporation tank is separated by a heat conduction plate to form a heating layer, and a heating part is arranged in the heating layer;
The evaporation tank is communicated with the crystallization tank through a vapor pipe, and an air exhaust part is connected to the evaporation pipe; the crystallizer is characterized in that a condensing plate is arranged inside the crystallizer to divide the crystallizer into a crystallization cavity and a condensation cavity, and the condensation cavity is connected with an external refrigerator through a condensing pipe.
Further, still include the feeding jar, the feeding jar is equipped with the feed opening, the feeding jar passes through the inlet pipe with the evaporating pot to be connected, be equipped with the valve on the inlet pipe, the inside second rabbling mechanism that is equipped with of feeding jar.
further, the second stirring mechanism comprises a second stirring motor and a second stirring shaft, and the output end of the second stirring motor transversely penetrates through the feeding tank and is connected with the second stirring shaft.
Further, the heating member is a heating wire.
Further, the air exhaust part is a steam jet vacuum pump.
Further, the condensing plate is longitudinally arranged inside the crystallizing tank.
Further, the condensing plate is transversely arranged inside the crystallizing tank.
Further, a condensed water outlet is formed in the bottom of the condensation cavity.
Further, a liquid outlet is arranged at the bottom of the crystallization cavity.
Furthermore, temperature sensors are arranged inside the crystallizing tank and the crystallizing cavity.
Compared with the prior art, the beneficial effects of the utility model are that: because the antibacterial peptide solution contains protein or organic matters with larger specific gravity, the bottom inside the bottom of the feeding tank is provided with the second stirring mechanism, the antibacterial peptide solution entering the crystallization tank is stirred for the first time, and the stirring effect of the whole crystallization device is optimal by matching with the first stirring mechanism inside the crystallization tank; in addition, the crystallization of the whole device can be continuously carried out, the crystallization efficiency is high, and the solution can be completely crystallized.
Drawings
Fig. 1 is a schematic front structural view of embodiment 1 of the present invention;
Fig. 2 is a schematic front structural view of embodiment 2 of the present invention;
Reference numerals
An evaporator 1; a crystallization tank 2; a feed inlet 3; a first stirring motor 4; a first stirring shaft 5; a heat-conducting plate 6; a heating means 7; a vapor tube 8; an air extracting part 9; a condensation plate 10; a crystallization chamber 11; a condensation chamber 12; a condenser tube 13; a refrigerator 14; a feed tank 15; a feed opening 16; a feed pipe 17; a valve 18; a second stirring motor 19; a second stirring shaft 20; a condensed water outlet 21; a liquid outlet 22.
Detailed Description
In order to make the technical solution of the present invention better understood, embodiments of the present invention are described in detail below with reference to the accompanying drawings.
In the description of the present invention, it should be noted that the terms "above", "one side", "the other side", "upper part", "lower part", "top", "bottom", "one end", "the other end", "bottom", "inside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present invention.
embodiment 1, with reference to fig. 1, an antibacterial peptide crystallization apparatus includes an evaporation tank 1 and a crystallization tank 2, the top of the evaporation tank is provided with a feed inlet 3, a first stirring mechanism is disposed inside the evaporation tank, the first stirring mechanism includes a first stirring motor 4 and a first stirring shaft 5, an output end of the first stirring motor passes through the bottom of the evaporation tank and is connected to the first stirring shaft, the stirring shaft is preferably a stirring shaft with a spiral piece, and the first stirring shaft extends from the bottom of the evaporation tank to the top of the evaporation tank; the inside of the evaporation tank is separated by a heat conduction plate 6 to form a heating layer, and a heating part 7 is arranged in the heating layer;
The evaporation tank is communicated with the crystallization tank through a steam pipe 8, and an air exhaust part 9 is connected to the evaporation pipe; the crystallizing tank is internally provided with a condensing plate 13 which divides the crystallizing tank into a crystallizing cavity 11 and a condensing cavity 12, and the condensing cavity is connected with an external refrigerator 14 through a condensing pipe 13.
In this embodiment, still include feed tank 15, feed tank is equipped with feed opening 16, feed tank passes through inlet pipe 17 with the evaporating pot and is connected, be equipped with valve 18 on the inlet pipe, the inside second rabbling mechanism that is equipped with of feed tank. The feed inlet of feed inlet pipe one end threaded connection mode connection feeding jar 16, the other end passes through threaded connection mode and connects evaporating pot feed inlet 3, makes feed inlet pipe intercommunication feed inlet jar be connected with the evaporating pot, needs to explain that the feed inlet pipe also can take other connected modes to be connected with feed inlet jar and evaporating pot.
In this embodiment, the second stirring mechanism includes a second stirring motor 19 and a second stirring shaft 20, and an output end of the second stirring motor transversely penetrates through the feeding tank and is connected with the second stirring shaft.
In this embodiment, the heating member 7 is a heating wire, and a plurality of heating wires are disposed around the heating layer. It should be noted that the heating means may take other heating means, for example, an electric heating tube.
In this embodiment, the evacuation unit 9 is a vapor jet vacuum pump.
In the present embodiment, the condensation plate 10 is longitudinally disposed inside the crystallization tank 2. It should be noted that, in embodiment 2, as shown in fig. 2, the condensation plate 10 is disposed laterally inside the crystallization tank 2.
In this embodiment, the bottom of the condensation chamber is provided with a condensed water outlet 21 for discharging condensed water during condensation.
In this embodiment, the bottom of the crystallization chamber is provided with a liquid outlet 22. After crystallization is finished, purified water is added to dissolve the crystal, and the antimicrobial peptide can be easily discharged from a liquid outlet and enters a chromatography process.
In this embodiment, the crystallization tank and the crystallization cavity are both provided with temperature sensors (not shown in the figure). Is used for monitoring the internal temperature of the evaporation tank in real time.
The utility model discloses a theory of operation: the antibacterial peptide spray liquid or solution enters from the feeding tank 15, because the antibacterial peptide solution contains protein or organic matter with larger specific gravity, the bottom inside the bottom of the feeding tank is provided with a second stirring mechanism, the antibacterial peptide solution entering the evaporation tank is stirred for the first time, the stirred antibacterial peptide solution enters the evaporation tank 1 through the feeding pipe 17, after the feeding is finished, the valve 18 is closed, the heating part 7 is heated, meanwhile, the first stirring mechanism is stirred to start evaporation crystallization, steam is generated after the antibacterial peptide solution is evaporated, the steam is pumped into the crystallization cavity 11 of the crystallization tank 2 by the steam jet vacuum pump, the refrigerator 14 blows cold air into the condensation cavity 12 to condense the steam, at the moment, the solution is in a saturated state, the solute is gradually separated out, the temperature sensor monitors the temperature inside the evaporation tank 1 and the crystallization cavity 11, thereby adjusting the refrigeration temperature of the refrigerator 14, after the solute is crystallized soon, the valve 18 is opened to continue discharging, so as to achieve the effect of continuous crystallization. The condensed water produced in the condensation process is discharged from a condensed water outlet 21 at the bottom of the condensation chamber. After crystallization is completed, purified water is added to dissolve the crystals, and the antimicrobial peptide can be easily discharged from the liquid outlet 22 and enter a chromatography process.
The following is the specific model and the effect of the part electric component that mentions in the utility model:
the model of the first stirring motor or the second stirring motor is selected as follows: BLD09-11-0.75KW, the stirring shaft is made of 304 stainless steel, and the antibacterial peptide solution is driven to rotate to achieve the effect of uniform stirring;
The heat conducting plate and the condensing plate are both made of aluminum plates with the thickness of 0.25cm, so that the heat conducting effect is good;
The heating wire adopts nichrome electrothermal alloy series, the advantage: the high-temperature strength is higher than that of iron, chromium and aluminum, the high-temperature alloy is not easy to deform under high-temperature use, the structure is not easy to change, the plasticity is better, the repair is easy, the radiance is high, and the high-temperature alloy is non-magnetic and strong in corrosion resistance;
the temperature sensor adopts a model WRN-122 thermocouple, and is cheap and durable;
The refrigerator adopts a miniature air cooler, an Oume miniature air cooler series, and the refrigeration effect completely meets the condensation requirement.
the steam jet vacuum pump adopts a constant HRPQ steam evacuation pump which can pump gas and can also be used for pumping liquid. Has the advantages of high vacuum degree, simple structure, low cost and the like, and is widely applied to the chemical production industry.
Because the antibacterial peptide solution contains protein or organic matters with larger specific gravity, the bottom inside the bottom of the feeding tank is provided with the second stirring mechanism, the antibacterial peptide solution entering the crystallization tank is well stirred, and the stirring effect of the whole crystallization device is optimal by matching with the first stirring device inside the crystallization tank; in addition, the crystallization of the whole device can be continuously carried out, the crystallization efficiency is high, and the solution can be completely crystallized.
The above only is the embodiment of the present invention, not limiting the patent scope of the present invention, all utilize the equivalent structure or equivalent flow transformation that the content of the specification does, or directly or indirectly use in other related technical fields, all including in the same way the patent protection scope of the present invention.
It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein, and any reference signs in the claims are not intended to be construed as limiting the claim concerned.
Claims (10)
1. an antibacterial peptide crystallization device, which is characterized in that: the device comprises an evaporation tank (1) and a crystallization tank (2), wherein a feed inlet (3) is formed in the top of the evaporation tank, a first stirring mechanism is arranged in the evaporation tank and comprises a first stirring motor (4) and a first stirring shaft (5), the output end of the first stirring motor penetrates through the bottom of the evaporation tank and is connected with the first stirring shaft, and the first stirring shaft extends from the bottom of the evaporation tank to the top of the evaporation tank; the inside of the evaporation tank is separated by a heat conduction plate (6) to form a heating layer, and a heating part (7) is arranged in the heating layer;
The evaporation tank is communicated with the crystallization tank through a steam pipe (8), and an air exhaust part (9) is connected to the evaporation pipe; the crystallizer is characterized in that a condensing plate (10) is arranged inside the crystallizer to divide the crystallizer into a crystallization cavity (11) and a condensation cavity (12), and the condensation cavity is connected with an external refrigerator (14) through a condensing pipe (13).
2. The antibacterial peptide crystallizing device according to claim 1, wherein: still include feed tank (15), the feed tank is equipped with feed opening (16), the feed tank passes through inlet pipe (17) with the evaporating pot and is connected, be equipped with valve (18) on the inlet pipe, the inside second rabbling mechanism that is equipped with of feed tank.
3. the antibacterial peptide crystallizing device according to claim 2, wherein: the second stirring mechanism comprises a second stirring motor (19) and a second stirring shaft (20), and the output end of the second stirring motor transversely penetrates through the feeding tank and is connected with the second stirring shaft.
4. The antibacterial peptide crystallizing device according to claim 1, wherein: the heating component is an electric heating wire.
5. the antibacterial peptide crystallizing device according to claim 1, wherein: the air extraction part is a steam jet vacuum pump.
6. The antibacterial peptide crystallizing device according to claim 1, wherein: the condensation plate (10) is longitudinally arranged inside the crystallization tank.
7. the antibacterial peptide crystallizing device according to claim 1, wherein: the condensation plate (10) is transversely arranged inside the crystallization tank.
8. The antibacterial peptide crystallizing device according to claim 1, wherein: and a condensed water outlet (21) is formed at the bottom of the condensation cavity.
9. The antibacterial peptide crystallizing device according to claim 1, wherein: a liquid outlet (22) is arranged at the bottom of the crystallization cavity.
10. The antibacterial peptide crystallizing device according to claim 1, wherein: and temperature sensors are arranged in the crystallizing tank and the crystallizing cavity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920573158.6U CN209778712U (en) | 2019-04-24 | 2019-04-24 | Antibacterial peptide crystallization device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920573158.6U CN209778712U (en) | 2019-04-24 | 2019-04-24 | Antibacterial peptide crystallization device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209778712U true CN209778712U (en) | 2019-12-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920573158.6U Active CN209778712U (en) | 2019-04-24 | 2019-04-24 | Antibacterial peptide crystallization device |
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| Country | Link |
|---|---|
| CN (1) | CN209778712U (en) |
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2019
- 2019-04-24 CN CN201920573158.6U patent/CN209778712U/en active Active
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