CN213210175U - Improved immunochromatographic test paper - Google Patents
Improved immunochromatographic test paper Download PDFInfo
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- CN213210175U CN213210175U CN202022373942.8U CN202022373942U CN213210175U CN 213210175 U CN213210175 U CN 213210175U CN 202022373942 U CN202022373942 U CN 202022373942U CN 213210175 U CN213210175 U CN 213210175U
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Abstract
The utility model discloses a modified immunochromatographic test paper, this modified immunochromatographic test paper include bottom plate, NC membrane, sample pad, gold mark pad, absorb water and fill up and block the rete, and the NC membrane is folded and is located on the bottom plate, and the both ends of bottom plate are located to sample pad and absorption water pad, and the both ends of gold mark pad are connected respectively in sample pad and NC membrane, block the one end adhesion of rete and fill up at gold mark pad or sample, the other end adhesion is at the NC membrane. The utility model discloses an improved immunochromatographic test paper, one end of a blocking film layer is adhered to a gold label pad or a sample pad, the other end is adhered to an NC membrane, so that the problem that the test paper is inclined after sample adding is solved, direct-current liquid quickly washes through a detection line and a quality control line area on the NC membrane, and flows away without reaching the combination, the liquid is blocked by the blocking film layer, so that the liquid can be prevented from flowing away quickly, and the detection precision is improved; the use of the film layer is blocked, the excessive pressure film is avoided, and the release of the gold label in the gold label layer is not influenced.
Description
Technical Field
The utility model relates to a medical science detects technical field, especially relates to a modified immunochromatographic test paper.
Background
The immunochromatographic test strip is a product which is commonly used in clinic. It can be classified into a quantitative chromatographic strip and a qualitative chromatographic strip according to the purpose of the test. According to the structure, it can be divided into naked chromatographic test strips and combined chromatographic test strips (test strips + card shell). The combined chromatographic test strip consists of a test strip and a card shell, the card shell is provided with a sample adding hole and an observation window, and the card shell can protect the chromatographic test strip inside, so the combined chromatographic test strip is more widely applied. When in test, a sample is added into the sample adding hole, the sample flows along the chromatographic test strip and passes through the combination pad, the test line T line and the quality control line C line, and the redundant liquid is absorbed by the absorbent paper.
The structure of the combined test strip in the prior art has certain disadvantages, and during testing, the test strip needs to keep absolute balance, and if the test strip has certain inclination, the test result can be influenced. The main reason for this is that the test strip is inclined during the test, the liquid is influenced by gravity, and the flow rate is changed, so that the binding time of the antigen and antibody is shortened, thereby affecting the test result. In the current structure, control is mainly performed through a structure on a clamping shell, for example, a pressing bar cylinder is added, and a gold marker end of the test strip is pressed through the cylinder, so that liquid is prevented from flowing downwards directly when the test strip inclines. However, the structure of the pressurizing column has the following defects:
1) if the pressing force is too tight, the liquid may not flow through the gold label pad smoothly, and the gold label substance in the gold label pad may not be completely released, thereby affecting the result.
2) If the pressure is too loose, it does not prevent the liquid from flowing downward.
Taking an antibody detection test strip of the novel coronavirus as an example, the detection test strip is a qualitative colloidal gold test strip. During testing, if the test strip is inclined after sample application or moves after sample application, the liquid is caused to flow directly, and the liquid is supposed to react and combine at the T line (detection line) and the C line (quality control line) ends, and is not combined due to too high flow rate. It may result in false negatives or directly in the failure of the C-line to show and the strip is voided.
SUMMERY OF THE UTILITY MODEL
In order to solve the above technical problem, embodiments of the present invention are expected to provide an improved immunochromatographic test strip which can block a direct current of a liquid when an inclination occurs, thereby improving detection accuracy.
The technical scheme of the utility model is realized like this:
the improved immunochromatographic test paper comprises a bottom plate, an NC membrane, a sample pad, a gold label pad, a water absorption pad and a blocking membrane layer, wherein the NC membrane is stacked on the bottom plate, the sample pad and the water absorption pad are respectively arranged at two ends of the bottom plate at intervals, two ends of the gold label pad are respectively connected to the sample pad and the NC membrane, one end of the blocking membrane layer is adhered to the gold label pad or the sample pad, and the other end of the blocking membrane layer is adhered to the NC membrane.
Preferably, the bottom of the blocking film layer protrudes a clamping table, the gold label pad or the sample pad is provided with a clamping groove, and the clamping table is embedded in the clamping groove.
Preferably, the clamping table is matched with the clamping groove in shape, and both the clamping table and the clamping groove are trapezoidal.
Preferably, the blocking film layer is adhered to a position where both the sample pad and the gold pad overlap.
Preferably, the blocking film layer is an adhesive paper layer.
Preferably, the NC membrane is provided with a detection line and a quality control line, the detection line and the quality control line are arranged at intervals, and the blocking membrane layer and the detection line are arranged at intervals and are located on one side, close to the gold label pad, of the detection line.
Preferably, the bottom plate is a PVC bottom plate.
Preferably, the middle part of the blocking film layer is a circular arc surface.
The embodiment of the utility model provides an improved immunochromatographic test paper through will block one end adhesion of rete and stick on gold mark pad or sample pad, the other end adhesion is in on the NC membrane, solve the test paper strip and take place to incline after the application of sample, direct current and liquid down rush through detection line and quality control line region on the NC membrane, the combination is not taken place to combine and just flows away, block the rete through setting up to liquid, can avoid the rapid flow away of liquid, improved detection accuracy effectively; and the use of the blocking film layer avoids the excessive pressure film, and the release of the gold label in the gold label layer is not influenced.
Drawings
FIG. 1 is a schematic structural diagram of the improved immunochromatographic test strip provided by the present invention;
fig. 2 is an enlarged view of a portion a shown in fig. 1.
Detailed Description
In order to illustrate embodiments of the present invention or technical solutions in the prior art more clearly, the following description will be made in conjunction with the accompanying drawings in embodiments of the present invention to describe the technical solutions in the embodiments of the present invention clearly and completely, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
Please refer to fig. 1, which is a schematic structural diagram of the improved immunochromatographic test strip provided by the present invention. The improved immunochromatographic test paper comprises a bottom plate 1, and an NC membrane 2, a sample pad 3, a gold label pad 4, a water absorption pad 5 and a blocking membrane layer 6 which are arranged on the bottom plate 1. The bottom plate 1 is a PVC bottom plate, namely a polyvinyl chloride bottom plate, and has stable material performance and low manufacturing cost.
The NC membrane 2 (namely, a nitrocellulose membrane) is stacked on the bottom plate 1, and is positioned in the middle section of the bottom plate 1. The NC membrane 2 is provided with a detection line 21 and a quality control line 22, the detection line 21 and the quality control line 22 are arranged at intervals, and the blocking membrane layer 6 and the detection line 21 are arranged at intervals and are positioned on one side of the detection line 21 close to the gold-labeled pad 4.
The sample pad 3 and the absorbent pad 5 are respectively arranged at two ends of the bottom plate 1, and two ends of the gold label pad 4 are respectively transitionally connected to the sample pad 3 and the NC membrane 2.
One end of the blocking film layer 6 is adhered to the gold label pad 4 or the sample pad 3, and the other end is adhered to the NC film 2. After the test strip is loaded, if the test strip is inclined, the liquid flowing downwards from the direct current is blocked by the blocking film layer 6, so that the liquid can be prevented from rapidly rushing through the detection line 21 and quality control line 22 areas on the NC film 2 and flowing away without being combined in time, and the detection precision is effectively improved; and the use of the blocking film layer 6 avoids the excessive pressure film, and the release of the gold label in the gold label layer is not influenced.
The blocking film layer 6 may be adhered to both the gold label pad 4 and the sample pad 3, and in this embodiment, the blocking film layer 6 is adhered to the gold label pad 4. Preferably, when the blocking film layer 6 is adhered to the upper surface of the sample pad 3, the position where the sample pad 3 and the gold label pad 4 are overlapped is not exceeded, that is, the blocking film layer 6 is adhered to the position where the sample pad 3 and the gold label pad 4 are overlapped, so as to prevent the blocking film layer 6 from being adhered to the sample pad 3 by an excessive length and exceeding the sample application hole of the card case, which may affect the application of the sample.
Specifically, in this embodiment, the blocking film layer 6 is a glue paper layer. Wherein, the blocking film layer 6 is soft or hard adhesive paper. Preferably, the blocking film layer 6 is soft adhesive paper. When the sample pad 3 or the gold mark pad 4 is attached, the middle part of the blocking film layer 6 is an arc surface, and the arc transition surface makes the blocking film layer 6.
Fig. 2 is an enlarged view of a portion a shown in fig. 1. The bottom of the blocking film layer 6 protrudes a clamping table 8, and the gold label pad 4 or the sample pad 3 is provided with a clamping groove 9. Specifically, in this embodiment, the card slot 9 is opened on the gold pad 4. The joint platform 8 inlays to be established in the draw-in groove 9, through the joint platform 8 inlays to be established in the draw-in groove 9, not only increased block the rete with the gold mark pad 4 perhaps the connection performance of sample pad 3 has improved moreover and has blocked liquid and has dashed gold mark pad 4 or sample pad 3 extremely the probability of NC membrane 2 blocks the effect better. The clamping table 8 plays a role of adding a pressing bar cylinder on a clamping shell in a part of the prior art, and the blocking film layer 6 also plays a blocking role, so that the blocking film layer 6 plays a role of double blocking, and the blocking effect is better.
The shape of the clamping table 8 is matched with that of the clamping groove 9, and the clamping table and the clamping groove are both trapezoidal. The trapezoidal structure is more convenient for the clamping table 8 with the assembly connection of clamping groove 9, structural stability is good.
The embodiment of the utility model provides an improved immunochromatographic test paper through will block one end adhesion of rete and stick on gold mark pad or sample pad, the other end adhesion is in on the NC membrane, solve the test paper strip and take place to incline after the application of sample, direct current and liquid down rush through detection line and quality control line region on the NC membrane, the combination is not taken place to combine and just flows away, block the rete through setting up to liquid, can avoid the rapid flow away of liquid, improved detection accuracy effectively; and the use of the blocking film layer avoids the excessive pressure film, and the release of the gold label in the gold label layer is not influenced.
The above description is only for the specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention should be covered by the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (8)
1. The improved immunochromatographic test paper is characterized by comprising a bottom plate, an NC membrane, a sample pad, a gold label pad, a water absorption pad and a blocking membrane layer, wherein the NC membrane is stacked on the bottom plate, the sample pad and the water absorption pad are respectively arranged at two ends of the bottom plate at intervals, two ends of the gold label pad are respectively connected to the sample pad and the NC membrane, one end of the blocking membrane layer is adhered to the gold label pad or the sample pad, and the other end of the blocking membrane layer is adhered to the NC membrane.
2. The improved immunochromatographic test strip of claim 1, wherein a clamping platform protrudes from the bottom of the blocking membrane layer, a clamping groove is formed on the gold label pad or the sample pad, and the clamping platform is embedded in the clamping groove.
3. The improved immunochromatographic test strip of claim 2, wherein the shape of the clamping table and the clamping groove are matched, both of which are trapezoidal.
4. The improved immunochromatographic test strip of claim 1, wherein the blocking membrane layer is adhered to a position where both the sample pad and the gold pad are overlapped.
5. The improved immunochromatographic test strip of claim 1, wherein said blocking membrane layer is a cellophane layer.
6. The improved immunochromatographic test strip of claim 1, wherein the NC membrane is provided with a detection line and a quality control line, the detection line and the quality control line are arranged at intervals, and the blocking membrane layer is arranged at intervals from the detection line and is positioned at one side of the detection line close to the gold-labeled pad.
7. The improved immunochromatographic test strip of claim 1, wherein said substrate is a PVC substrate.
8. The improved immunochromatographic test strip of claim 1, wherein the middle portion of the blocking membrane layer is a circular arc surface.
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CN202022373942.8U CN213210175U (en) | 2020-10-22 | 2020-10-22 | Improved immunochromatographic test paper |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113466461A (en) * | 2021-08-20 | 2021-10-01 | 广东省第二人民医院(广东省卫生应急医院) | Phospholipase A2 lateral chromatography detection test strip, detection card and application thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN113466461A (en) * | 2021-08-20 | 2021-10-01 | 广东省第二人民医院(广东省卫生应急医院) | Phospholipase A2 lateral chromatography detection test strip, detection card and application thereof |
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