CN212808307U - Flat plate agglutination test device - Google Patents
Flat plate agglutination test device Download PDFInfo
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- CN212808307U CN212808307U CN202021497881.XU CN202021497881U CN212808307U CN 212808307 U CN212808307 U CN 212808307U CN 202021497881 U CN202021497881 U CN 202021497881U CN 212808307 U CN212808307 U CN 212808307U
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- agglutination test
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Abstract
The utility model discloses a dull and stereotyped agglutination test device, including the reaction plate, the reaction plate is dull and stereotyped structure, just the top surface of reaction plate is equipped with a plurality of to the epirelief and is the ring boss that the matrix distributes, every the inner circumference of ring boss with enclose into a reaction tank between the top surface of reaction plate. The reaction plate of the utility model is provided with the circular bosses, which can form independent reaction tanks, even if the liquid in some reaction tanks overflows, the overflow liquid only flows into the gaps between the circular bosses along the outer circumferential wall of the circular bosses, thus not polluting the samples in other reaction tanks and improving the performance of the reaction plate against cross contamination; and the setting of reaction tank on this reaction plate can be fit for 8 and 12 way pipettors and move the liquid operation, promotes and moves liquid efficiency to satisfy big sample detection demand in batches.
Description
Technical Field
The utility model relates to a biological test apparatus technical field, in particular to dull and stereotyped agglutination test device.
Background
Agglutination assays are serological assays in which particle antigens are agglutinated upon binding to the corresponding antibody. The complex of the antigen and the antibody forms an agglutination mass visible to the naked eye after a certain time under the action of the electrolyte. Agglutination tests are performed on plates, i.e., plate agglutination tests. The reaction plate of the traditional flat plate agglutination test generally uses a glass plate as a medium, wherein the glass plate needs to be repeatedly cleaned, so that higher biological potential safety hazards exist, and the sample cross contamination is easily caused when the reaction plate is moved. At present, a reaction plate with a plurality of grooves is provided, a plurality of grooves for reaction are punched on the reaction plate, but the top surfaces of the openings of the grooves are still positioned on the same plane with the top surface of the reaction plate, if the operation is wrong, liquid in some grooves overflows, the overflowing liquid flows into other grooves along the top surface of the reaction plate to pollute samples in other grooves, and the performance of preventing cross contamination is still poor; in addition, the reaction plate has a small groove area and a circular arc structure at the bottom surface, so that the liquid is gathered and is not light-tight, and the observation of whether the agglutinated particles are generated is not facilitated.
The information disclosed in this background section is only for enhancement of understanding of the general background of the invention and should not be taken as an acknowledgement or any form of suggestion that this information constitutes prior art already known to a person skilled in the art.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a dull and stereotyped agglutination test device to overcome current reaction plate and prevent that cross contamination performance is poor and be unfavorable for observing the shortcoming of agglutinate particle.
In order to achieve the above object, the utility model provides a dull and stereotyped agglutination test device, including the reaction plate, the reaction plate is the plate structure, just the top surface of reaction plate is equipped with the ring boss that a plurality of is matrix distribution, every to the epirelief the inner circumference of ring boss with enclose into a reaction tank between the top surface of reaction plate.
Preferably, in the above technical solution, the reaction plate is rectangular.
Preferably, in the above technical solution, a circle of baffle is convexly provided upwards at the peripheral edge of the reaction plate, and the height of the baffle is greater than the height of the circular boss.
Preferably, in the above technical solution, the baffle is disposed obliquely outward from bottom to top.
Preferably, in the above technical solution, all the circular bosses are uniformly arranged in rows and columns, and each row is provided with a row number and each column is provided with a column number.
Preferably, in the above technical solution, a distance between centers of two adjacent reaction tanks on the left and right sides and a distance between centers of two adjacent reaction tanks on the front and back sides are equal to twice a distance between two adjacent liquid suction nozzles in the multi-channel pipette; wherein the diameter of each circular boss is 9-18 mm.
Preferably, in the above technical solution, the reaction plate is made of polystyrene material.
Preferably, in the above technical scheme, the sample adding device further comprises a sample adding plate, wherein a plurality of placing holes distributed in a matrix are formed in the sample adding plate, the placing holes and the reaction grooves are distributed in a one-to-one correspondence manner, and each placing hole is used for placing one sample tube.
Preferably, in the above technical solution, all the placing holes are uniformly arranged in rows and columns, and each row is provided with a row number and each column is provided with a column number.
Preferably, in the above technical solution, a distance between centers of two adjacent left and right placement holes and a distance between centers of two adjacent front and rear placement holes is equal to twice a distance between two adjacent liquid suction nozzles in the multi-channel pipette; wherein, the depth of each placing hole is 15-30 mm.
Compared with the prior art, the utility model discloses following beneficial effect has:
1. the reaction plate of the utility model is of a flat plate structure, the circular bosses arranged on the reaction plate can be enclosed into independent reaction tanks, even if liquid in some reaction tanks overflows, the overflow liquid only flows into gaps between the circular bosses along the outer circumferential wall of the circular bosses, so that samples in other reaction tanks can not be polluted, and the cross contamination prevention performance of the reaction plate is improved; a reaction tank is enclosed between the inner circumferential surface of each circular boss and the top surface of the reaction plate, so that the bottom surface of the reaction tank can be ensured to be of a planar structure, the agglutination test principle of the reaction plate is more real, and the test result can be conveniently observed; wherein, the setting up of reaction tank can be fit for 8 and 12 way pipettors and move the liquid operation on this reaction plate, promotes and moves liquid efficiency to satisfy big batch sample detection demand.
2. The edge around the reaction plate of the utility model is provided with a circle of baffle plate upwards in a protruding way, which is convenient for taking the reaction plate and can prevent the liquid overflowing from the reaction tank from flowing out along the edge of the reaction plate, so as to limit all samples on the reaction plate, avoid the samples from polluting the experimental environment and have good biological safety performance; wherein, the height of baffle is greater than the height of ring boss, and the baffle sets up from supreme slope outwards, is convenient for stack of a plurality of reaction plates to be convenient for deposit and transport of reaction plate.
3. The utility model discloses a reaction plate is made by the polystyrene material, not only does benefit to and observes agglutinate particle and judgement experimental result, can also regard as disposable reaction plate to use the reaction plate, uses the back, can be convenient for it and medical discarded object carry out biological safety together and handle.
4. The utility model discloses a test device is still including adding the model for place the sample cell, the multichannel pipettor of being convenient for inhales the intraductal sample of sample, once shifts a plurality of samples to the reaction tank that corresponds in the reaction plate in, improves work efficiency.
Drawings
FIG. 1 is a schematic front view of a reaction plate of a plate agglutination test apparatus according to the present invention.
Fig. 2 is a schematic sectional view taken along line a-a of fig. 1 according to the present invention.
Fig. 3 is a schematic structural view of a multi-channel pipette for applying sample to a reaction plate according to the present invention.
Fig. 4 is a schematic front view of a sample adding plate according to the present invention.
Fig. 5 is a schematic diagram of a multi-channel pipette according to the present invention for sampling on a sample adding plate.
Description of the main reference numerals:
1-reaction plate, 11-circular boss, 12-reaction tank, 13-baffle, 2-multi-channel pipettor, 3-sample adding plate, 31-placing hole and 4-sample tube.
Detailed Description
The following detailed description of the present invention is provided in conjunction with the accompanying drawings, but it should be understood that the scope of the present invention is not limited by the following detailed description.
Throughout the specification and claims, unless explicitly stated otherwise, the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element or component but not the exclusion of any other element or component.
FIGS. 1 to 5 are schematic views showing the structure of a plate agglutination test apparatus according to a preferred embodiment of the present invention, which comprises a reaction plate 1. Referring to fig. 1 to 3, the reaction plate 1 is a flat plate structure, and a plurality of circular bosses 11 are protruded upward from the top surface of the reaction plate 1 and distributed in a matrix, that is, the circular bosses 11 are circular, and the top surface and the bottom surface of each circular boss 11 are both open, so that a reaction tank 12 is defined between the inner circumferential surface of each circular boss 11 and the top surface of the reaction plate 1. The circular bosses 11 arranged on the reaction plate 1 of the utility model can be used for enclosing into independent reaction tanks 12, even if liquid in some reaction tanks 12 overflows, the overflow liquid only flows into gaps between the circular bosses 11 along the outer circumferential wall of the circular bosses 11, thus not polluting samples in other reaction tanks 12 and improving the performance of preventing cross contamination of the reaction plate 1; and a reaction tank 12 is enclosed between the inner circumferential surface of each circular boss 11 and the top surface of the reaction plate 1, so that the bottom surface of the reaction tank 12 can be ensured to be a planar structure, the agglutination test principle of the reaction plate is more real, and the test result can be conveniently observed; wherein, the setting up of reaction tank 12 on this reaction plate 1 can be fit for 8 and 12 way pipettors and move the liquid operation, promotes and moves liquid efficiency to satisfy big batch sample detection demand.
Referring to fig. 1 to 3, the reaction plate 1 may have a circular, rectangular or polygonal shape, and in order to facilitate the arrangement of the circular bosses 11 distributed in a matrix and improve the utilization rate of the area of the reaction plate 1, the reaction plate 1 is preferably rectangular.
Referring to fig. 1 to 3, preferably, the edge all around of reaction plate 1 is equipped with round baffle 13 to the epirelief, can be equipped with a baffle 13 at the edge of the four sides of rectangular reaction plate 1, all baffles 13 connect gradually end to end, thereby enclose into a rectangular frame structure, enclose all ring bosses 11 in this rectangular frame, be convenient for take of reaction plate 1, and can prevent that the liquid that overflows in the reaction tank 12 from flowing along the edge of reaction plate 1, with all sample restrictions on reaction plate 1, avoid the sample to pollute experimental environment, and has good biosafety performance. And further preferably, the height of the baffle 13 is greater than that of the circular boss 11, and the baffle 13 is inclined outwards from bottom to top, so that a plurality of reaction plates 1 can be stacked conveniently, and the storage and transportation of the reaction plates 1 are facilitated.
Referring to fig. 1 to 3, preferably, all the circular bosses 11 are uniformly arranged in rows and columns, and each row is provided with a row number and each column is provided with a column number, so that each sample can be distinguished conveniently, and the test result can be recorded.
Referring to fig. 1 to 3, it is preferable that a distance S between centers of two adjacent reaction tanks 12 on the left and right is provided1And the distance S between the centers of two adjacent reaction tanks 121The distance between two adjacent liquid suction nozzles in the multi-channel pipettor 2 is twice, so that the pipetting use of 8-channel pipettors and 12-channel pipettors is compatible, the multi-channel pipettors 2 can be used in a channel-by-channel mode, the area of the reaction tank 12 is increased, and the reaction result can be observed conveniently. Wherein, the distance between two adjacent liquid suction nozzles in the multi-channel liquid moving device 2 is 9mm, so the distance S between the circle centers of two adjacent reaction tanks 12 at the left and the right is1And front and backThe distance S between the centers of circles of the adjacent reaction tanks 121Are all 18mm, and the diameter d of each circular boss 111Is 9-18 mm.
Referring to fig. 1 to 3, reaction plate 1 is preferably made of polystyrene material, which not only facilitates observation of aggregated particles and determination of experimental results, but also allows reaction plate 1 to be used as a disposable reaction plate 1, which facilitates bio-safety treatment with medical waste after use.
Referring to fig. 4 and 5, preferably, the testing apparatus further includes a sample adding plate 3, a plurality of placing holes 31 are disposed on the sample adding plate 3, and the placing holes 31 are disposed in a matrix, and are in one-to-one correspondence with the reaction wells 12, wherein each placing hole 31 is used for placing one sample tube 4, a sample to be tested is stored in each sample tube 4, and a multi-channel pipette 2 is used to transfer the liquid in the sample tube 4 to the corresponding reaction well 12.
Referring to fig. 4 and 5, preferably, all the placing holes 31 are uniformly arranged in rows and columns, and each row is provided with a row number and each column is provided with a column number, so that each sample species can be distinguished and recorded.
Referring to fig. 4 and 5, it is preferable that a distance S between centers of two adjacent left and right placing holes 312And the distance S between the centers of two adjacent placing holes 312Equal to twice the distance between two adjacent pipette tips in the multi-channel pipette 2, i.e., the distance S between the centers of two adjacent left and right placement holes 312And the distance S between the centers of two adjacent placing holes 312Are all 18mm, so that the sample tube 4 is arranged corresponding to the reaction groove 12, and a plurality of pipettes 2 can take liquid from different channels conveniently. Wherein the sample tube 4 can be a 1.5mL or 2mL centrifuge tube, the depth h of the placing hole 31 is 15-30 mm, and the diameter d of the placing hole 312Is 10-12 mm to can fix sample cell 4, avoid sample cell 4 excessive slope, thereby be convenient for the liquid of getting of multichannel liquid taker 2.
The bottom surface of the reaction tank 12 of the test device of the utility model is a plane structure, which can more truly reflect the plate agglutination test principle and is convenient for observing the test result; the annular boss 11 arranged on the reaction plate 1 can further improve the cross contamination prevention performance of the reaction plate 1; the periphery of reaction plate 1 sets up baffle 13, not only can be convenient for take, deposit and transport, can also prevent that the liquid on the reaction plate 1 from leaking outward, avoids sample pollution experimental environment, has fine biological safety performance.
The foregoing descriptions of specific exemplary embodiments of the present invention have been presented for purposes of illustration and description. It is not intended to limit the invention to the precise form disclosed, and obviously many modifications and variations are possible in light of the above teaching. The exemplary embodiments were chosen and described in order to explain certain principles of the invention and its practical application to enable one skilled in the art to make and use various exemplary embodiments of the invention and various alternatives and modifications as are suited to the particular use contemplated. It is intended that the scope of the invention be defined by the claims and their equivalents.
Claims (10)
1. The flat plate agglutination test device is characterized by comprising a reaction plate, wherein the reaction plate is of a flat plate structure, a plurality of circular bosses distributed in a matrix manner are arranged on the top surface of the reaction plate in an upward protruding manner, and a reaction tank is defined between the inner circumferential surface of each circular boss and the top surface of the reaction plate.
2. The plate agglutination test apparatus according to claim 1 wherein said reaction plate is rectangular.
3. The plate agglutination test apparatus of claim 1 wherein said reaction plate has a ring of baffles protruding upwardly from the peripheral edge of said reaction plate.
4. The plate agglutination test apparatus according to claim 3 wherein said baffle plate has a height greater than the height of said annular boss, and said baffle plate is disposed inclined outwardly from the bottom to the top.
5. The plate agglutination test apparatus of claim 1 wherein all of said circular bosses are uniformly arranged in rows and columns, and wherein each row is provided with a row number and each column is provided with a column number.
6. The plate agglutination test apparatus according to claim 1 wherein the distance between the centers of the left and right adjacent reaction wells and the distance between the centers of the front and rear adjacent reaction wells is equal to twice the distance between two adjacent pipette tips in the multi-channel pipette; wherein the diameter of each circular boss is 9-18 mm.
7. The plate agglutination test apparatus of claim 1 wherein said reaction plate is made of a polystyrene material.
8. The plate agglutination test apparatus according to claim 1 further comprising a sample adding plate, wherein said sample adding plate is provided with a plurality of placing holes distributed in a matrix, and said placing holes are distributed in one-to-one correspondence with said reaction wells, wherein each of said placing holes is used for placing a sample tube.
9. The plate agglutination test apparatus according to claim 8 wherein all of said placement holes are uniformly arranged in rows and columns, and wherein each row is provided with a row number and each column is provided with a column number.
10. The plate agglutination test apparatus according to claim 8 wherein the distance between the centers of two adjacent left and right placement holes and the distance between the centers of two adjacent front and rear placement holes is equal to twice the distance between two adjacent pipette tips in a multi-channel pipette; wherein, the depth of each placing hole is 15-30 mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021497881.XU CN212808307U (en) | 2020-07-23 | 2020-07-23 | Flat plate agglutination test device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021497881.XU CN212808307U (en) | 2020-07-23 | 2020-07-23 | Flat plate agglutination test device |
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| Publication Number | Publication Date |
|---|---|
| CN212808307U true CN212808307U (en) | 2021-03-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202021497881.XU Active CN212808307U (en) | 2020-07-23 | 2020-07-23 | Flat plate agglutination test device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114214169A (en) * | 2021-11-28 | 2022-03-22 | 美东汇成生命科技(昆山)有限公司 | Cross infection prevention PCR plate |
-
2020
- 2020-07-23 CN CN202021497881.XU patent/CN212808307U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114214169A (en) * | 2021-11-28 | 2022-03-22 | 美东汇成生命科技(昆山)有限公司 | Cross infection prevention PCR plate |
| CN114214169B (en) * | 2021-11-28 | 2023-10-13 | 美东汇成生命科技(昆山)有限公司 | PCR plate for preventing cross infection |
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