CN212540128U - Biochemical analyzer - Google Patents

Abstract

The utility model discloses a biochemical analyzer. The biochemical analyzer is used for analyzing and testing a sample to be tested on the test paper. The biochemical analyzer includes a light path component and a housing component. The light path component comprises a light source component, a heating element and a temperature sensing element, the light source component is used for emitting light rays to the test paper, the heating element is used for transferring the generated heat to the light source component, and the temperature sensing element is used for detecting the temperature of the light source component; the optical path assembly is located within the housing assembly. The utility model provides a light path subassembly among the biochemical analyzer can be heated to required temperature, and then reduces ambient temperature's change to the influence of test result.

Description

Biochemical analyzer

Technical Field

The utility model relates to an analysis and test technical field especially relates to a biochemical analyzer.

Background

A biochemical analyzer, also called biochemical analyzer, is a biochemical detection device for detecting and feeding back multiple samples or multiple items. The detection principle of the biochemical analyzer is to detect a certain characteristic chemical component in a sample based on the photoelectric colorimetric principle. The biochemical analyzer has the advantages of high detection speed, high accuracy, low consumption of dosage and the like, and is widely applied to places such as hospitals, epidemic prevention stations, quarantine stations and the like.

The current biochemical analyzer mainly comprises a sample adding system, a temperature control system, a software system and the like. However, due to the influence of the ambient temperature, the test results of the biochemical instruments on the existing market are difficult to maintain stable and accurate.

SUMMERY OF THE UTILITY MODEL

The main object of the utility model is to provide a biochemical analyzer, make it can reduce ambient temperature to the influence of test result.

The embodiment of the utility model provides a biochemical analyzer. The biochemical analyzer is used for analyzing and testing a sample to be tested on the test paper. The biochemical analyzer includes:

the test paper detection device comprises a light path component, a heating element and a temperature sensing element, wherein the light path component comprises a light source component, the heating element and the temperature sensing element, the light source component is used for emitting light rays to irradiate the test paper, the heating element is used for transferring generated heat to the light source component, and the temperature sensing element is used for detecting the temperature of the light source component; and

a housing assembly, the optical path assembly located within the housing assembly.

The third heating element transfers the generated heat to the light source assembly, so that the temperature of the light source assembly reaches the required temperature, and the influence of the change of the ambient temperature on the test result of the biochemical analyzer is reduced.

In some embodiments, the light path assembly further includes a first fixing seat, the light source assembly and the heating element are both mounted on the first fixing seat, and a surface of the heating element has a thermally conductive silicone.

The light source assembly and the third heating element are both mounted on the first fixing seat, so that heat of the third heating element can be transmitted to the light source assembly through the first fixing seat, and the light source assembly can reach the temperature required by work. The heat conducting silica gel can accelerate the heat transfer.

In some embodiments, the heating element comprises an aluminum substrate material. The aluminum metal has excellent heat conductivity, so that the heating element made of the aluminum base material has excellent heating effect.

In some embodiments, the biochemical analyzer further comprises a control unit, the heating element having a heating circuit, the heating circuit and the temperature sensing element both being electrically connected to the control unit. And the control unit controls the heating circuit to work and be disconnected according to the temperature value detected by the third temperature sensing element. The temperature of the light source component is adjusted in a closed-loop feedback control mode to be basically kept constant, and the temperature cannot fluctuate greatly.

In some embodiments, the biochemical analyzer further comprises a control unit, the light source assembly comprises a first LED light assembly with a wavelength of 405nm, a second LED light assembly with a wavelength of 550nm and a third LED light assembly with a wavelength of 610nm, and the control unit is used for controlling the switching of the power-on state and the power-off state of at least one of the first LED light assembly, the second LED light assembly and the third LED light assembly.

The reagent of the biochemical analyzer and the sample to be tested have selectivity for the absorption of the wavelength, so that different biochemical analyzer test items need to adopt different wavelengths. The control unit can control the LED lamp assembly having a desired wavelength to be in an energized state according to the user's needs.

In some embodiments, the light source assembly comprises an LED lamp assembly including an LED lamp, a sleeve, and a convex mirror, the LED lamp is mounted in the sleeve, the convex mirror is mounted at one end of the sleeve, the sleeve is provided with a light hole, and light of the LED lamp can penetrate through the light hole and enter the surface of the convex mirror. The convex lens can enable light emitted by the LED lamp to converge to a target position (such as test paper coated with a chemical reagent and receiving a sample to be detected), and parameters of the sample to be detected are determined by calculating the degree of light absorption.

In some embodiments, the LED lamp assembly further comprises a PCBA board electrically connected to the LED lamp, the PCBA board being mounted to the other end of the sleeve. Through the electrical connection of PCBA board and LED lamp for the switching of the circular telegram state of LED lamp can be controlled with the outage state.

In some embodiments, the light path component further includes a photodiode, the photodiode is mounted below the first fixing seat, and the photodiode is configured to receive light reflected by the test paper after the light from the LED lamp is directed to the test paper. By means of the photodiode, the absorbance can be calculated, and the calculation formula of the absorbance can be expressed as the absorbance-lg (reflected light/incident light), so that the corresponding parameter value of the sample to be measured is calculated through the absorbance.

In some embodiments, the biochemical analyzer further includes a scanning component and a control unit, the test strip has encoded information thereon, the scanning component is configured to scan the encoded information to identify a type of the test strip and transmit the type of the test strip to the control unit, and the control unit is configured to control an on-off state of the light source component. The one-dimensional code, the two-dimensional code, and the three-dimensional code are all readable by a machine device, so that the type of the test paper can be identified.

In some embodiments, the housing assembly is an enclosed structure. The shell assembly with the closed structure provides mounting positions for all assemblies inside the shell assembly and isolates external light so as to avoid the influence of the external light on the light path assembly.

Drawings

Fig. 1 is a schematic structural diagram of a housing assembly according to an embodiment of the present invention;

fig. 2 is an assembly structure diagram of the cabin access assembly in the embodiment of the present invention;

fig. 3 is an exploded schematic view of the cabin entering and exiting assembly in the embodiment of the present invention;

fig. 4 is a schematic structural diagram of a scanning assembly in an embodiment of the present invention;

fig. 5 is a schematic view of an assembly structure of the optical path component in the embodiment of the present invention;

fig. 6 is an exploded schematic view of an optical path module according to an embodiment of the present invention;

fig. 7 is a cross-sectional view of an optical circuit assembly in an embodiment of the present invention;

fig. 8 is a schematic view of an assembly structure of the tray assembly in an embodiment of the present invention;

fig. 9 is an exploded view of the tray assembly according to an embodiment of the present invention;

fig. 10 is a schematic view of an assembly structure of the pressing block assembly in the embodiment of the present invention;

fig. 11 is a cross-sectional view of a pressure block assembly in an embodiment of the present invention;

fig. 12 is an exploded view of the housing assembly according to an embodiment of the present invention;

FIG. 13 is a schematic view of an exploded structure of a test strip assembly according to an embodiment of the present invention;

fig. 14 is a schematic view (top view) illustrating an assembly structure of the test strip assembly according to an embodiment of the present invention;

fig. 15 is a schematic structural view of the tray assembly extending out of the housing assembly according to the embodiment of the present invention.

Reference numerals:

10-a biochemical analyzer;

100-a housing assembly;

200-an in-out cabin assembly; 210-a third scaffold; 220-a step motor; 221-a first screw part, 222-a second screw part, 223-a fixed flange seat; 230-tray changeover elements; 240-guide rail, 241-guide rail mounting seat; 250-optical couplers; 260-a bearing; 270-optical coupling baffle plate;

300-a scanning component, 310-a scanner, 320-a scanner holder;

400-an optical path component; 410-a first LED lamp assembly, 411-a first LED lamp, 412-a first sleeve, 413-a first convex mirror, 414-a first PCBA board, 415-a first convex mirror fixed cover; 420-a second LED lamp assembly; 430-a third LED lamp assembly; 440-a third heating element; 461-first fixed seat; 470-a photodiode;

500-a tray assembly; 510-a tray body, 511-a tray upper cover, 512-a tray lower cover and 513-a test paper component fixing groove; 520-a first heating element, 521-a first temperature sensing element; 522-first over-temperature protection switch; 530-calibration object, 531-calibration object storage tank and 532-calibration object fixing cover; 541-a heat insulation pad;

600-a briquetting assembly; 610-an actuation mechanism; 611-a first bracket, 6111-a first bracket upper fixing cover, 6112-a first bracket lower fixing cover; 612-a second bracket; 613-an electromagnet; 614-guide shaft, 6141-guide shaft thread head; 615-linear bearing, 6151-bearing fixing cover, 6152-bearing buffer ring; 616-a compression spring; 617-an electromagnet connecting element; 618-briquetting body; 620-a heating mechanism; 621-a second heating element; 622-second over-temperature protection switch; 623-a second temperature sensing element;

700-test paper assembly; 710-first support element, 711-first through hole; 720-second support element, 721-second through hole; 730-a permeate membrane layer; 740-a reagent film layer; 750-identification code layer.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are exemplary only for the purpose of explaining the present invention, and should not be construed as limiting the present invention. The technical solutions of the embodiments of the present invention can be combined with each other, but should be implemented by those skilled in the art.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear" and "left", "right", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the term "connected" is to be interpreted broadly, and may be, for example, a fixed connection and a movable connection, a detachable connection and a non-detachable connection, or an integral connection; may be mechanically or electrically connected or may be in communication with each other. And "fixedly connected" includes detachably connected, non-detachably connected, integrally connected, and the like.

In the present application, references to terms like "first" or "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. In the present invention, references to "vertical" and "horizontal" are not intended to refer to absolute vertical and absolute horizontal only, but also to include substantially vertical and substantially horizontal as is acceptable in the art.

The embodiment of the utility model provides a biochemical analyzer. Referring to fig. 1 to 15, a biochemical analyzer 10 is used for analyzing and testing a sample to be tested on a test strip, and the biochemical analyzer 10 includes an optical path component 400 (see fig. 5 to 7) and a housing component 100 (see fig. 1). The light path assembly 400 includes a light source assembly for emitting light to irradiate the test paper, a third heating element 440 for transferring the generated heat to the light source assembly, and a third temperature sensing element (not shown in the figure) for detecting the temperature of the light source assembly. The light path assembly 400 is located within the housing assembly 100.

The third heating element transfers the generated heat to the light source assembly, including the third heating element directly heating the light source assembly (i.e., by thermal conduction) and also including the third heating element transferring heat to the light source assembly without contact to heat it up (i.e., by thermal convection or thermal radiation).

The sample to be tested and the reagent in the biochemical analyzer are subjected to biochemical reaction, the activity of the enzyme influences the result of the biochemical reaction, and the activity of the enzyme is influenced by the environmental temperature. Therefore, it is important that the operating environment of the biochemical analyzer be at a desired temperature.

The third heating element transfers the generated heat to the light source assembly, so that the temperature of the light source assembly reaches a required temperature (for example, 37 ℃), and the influence of the change of the environmental temperature on the test result of the biochemical analyzer is reduced.

Referring to fig. 5 to 7, in some embodiments, the light path assembly 400 further includes a first fixing seat 461, the light source assembly and the third heating element 440 are both mounted on the first fixing seat 461, and a surface of the third heating element 440 has a thermal conductive silicone. The heat-conducting silica gel has good heat conductivity and good electrical insulation, and also has wider use temperature.

The third heating element is used as a heating body, and heat conducting silica gel is coated on the surface of the third heating element, so that the heat transfer can be accelerated. The light source assembly and the third heating element are both mounted on the first fixing seat, so that heat of the third heating element can be transmitted to the light source assembly through the first fixing seat, and the light source assembly can reach the temperature required by work.

In some embodiments, the third heating element 440 comprises an aluminum substrate material. The aluminum metal has excellent heat conductivity, so that the heating element made of the aluminum base material has excellent heating effect.

In some embodiments, the biochemical analyzer 10 further comprises a control unit (not shown), the third heating element 440 has a heating circuit, and both the heating circuit and the third temperature sensing element are electrically connected to the control unit. And the control unit controls the heating circuit to work and be disconnected according to the temperature value detected by the third temperature sensing element. The temperature of the light source component is adjusted in a closed-loop feedback control mode to be basically kept constant, and the temperature cannot fluctuate greatly.

With continued reference to fig. 5-7, in some embodiments, the biochemical analyzer 10 further includes a control unit, the light source assembly includes a first LED lamp assembly 410 with a wavelength of 405nm, a second LED lamp assembly 420 with a wavelength of 550nm, and a third LED lamp assembly 430 with a wavelength of 610nm, and the control unit is configured to control switching of an on state and an off state of at least one of the first LED lamp assembly 410, the second LED lamp assembly 420, and the third LED lamp assembly 430.

The reagent of the biochemical analyzer and the sample to be tested have selectivity for the absorption of the wavelength, so that different biochemical analyzer test items need to adopt different wavelengths. The control unit can control the LED lamp assembly having a desired wavelength to be in an energized state according to the user's needs.

With continued reference to fig. 5-7, in some embodiments, the light source assembly includes a first LED light assembly 410, a second LED light assembly 420, and a third LED light assembly 430. The composition of the LED lamp assembly is described below by taking the first LED lamp assembly 410 as an example. The second LED lamp assembly 420 and the third LED lamp assembly 430 are made up as described above with reference to the first LED lamp assembly 410.

The first LED lamp assembly 410 includes a first LED lamp 411, a first sleeve 412 and a first convex mirror 413, the first LED lamp 411 is installed in the first sleeve 412, the first convex mirror 413 is installed at one end of the first sleeve 412, the first sleeve 412 is provided with a light hole, and light of the first LED lamp 411 can penetrate through the light hole and enter the surface of the first convex mirror 413. The convex lens can enable light emitted by the LED lamp to converge to a target position (such as test paper coated with a chemical reagent and receiving a sample to be detected), and parameters of the sample to be detected are determined by calculating the degree of light absorption.

With continued reference to fig. 5-7, in some embodiments, the LED lamp assembly further includes a PCBA board. The composition of the LED lamp assembly is described below by taking the first LED lamp assembly 410 as an example. The second LED lamp assembly 420 and the third LED lamp assembly 430 are made up as described above with reference to the first LED lamp assembly 410.

The first LED lamp assembly 410 also includes a first PCBA board 414. A first PCBA board 414 is electrically connected to the first LED lamp 411, the first PCBA board 414 being mounted to the other end of the first sleeve 412. Through the electrical connection of PCBA board and LED lamp for the switching of the circular telegram state of LED lamp can be controlled with the outage state.

Referring to fig. 5 to 7, in some embodiments, the light path assembly 400 further includes a photodiode 470, the photodiode 470 is installed below the first fixing seat 461, and the photodiode 470 is used for receiving light reflected by the test paper after the light from the LED lamp is emitted to the test paper. By means of the photodiode, the absorbance can be calculated, and the calculation formula of the absorbance can be expressed as the absorbance-lg (reflected light/incident light), so that the corresponding parameter value of the sample to be measured is calculated through the absorbance.

In some embodiments, as shown in fig. 5 to 7, the light path assembly 400 includes a first LED lamp assembly 410 (wavelength of 405nm), a second LED lamp assembly 420 (wavelength of 550nm), a third LED lamp assembly 430 (wavelength of 610nm), a third heating element 440, a photodiode 470 and a first fixing base 461 (made of aluminum substrate). The optical path component 400 is used as a core component of the biochemical analyzer 10, and is used for realizing the test of the test paper based on the photoelectric colorimetric principle. Each of the components of the optical circuit assembly 400 is fixed to the first fixing base 461 by a screw connection member. The first LED lamp assembly 410, the second LED lamp assembly 420, and the third LED lamp assembly 430 are identical in structure. Taking the first LED lamp assembly 410 as an example, the first LED lamp assemblies 410 each include a first LED lamp 411, a first sleeve 412, a first convex mirror 413, a first convex mirror fixing cover 415, and a first PCBA board 414. The first sleeve 412 is made of aluminum base material, and the first sleeve 412 has a light hole therein.

The operation of the optical path assembly 400 can be briefly described as follows: after the biochemical analyzer 10 identifies the type of the test paper through the scanning component 300, the corresponding LED lamp is controlled to be powered on. As shown in fig. 7, taking the first LED lamp assembly 410 as an example, light generated by the LED lamp is transmitted through the light-transmitting hole of the first sleeve 412 to irradiate the surface of the first convex mirror 413, and is refracted along the first convex mirror 413 to generate a parallel light beam. In fig. 7, the direction of the arrow indicates the direction of the optical path. As shown in fig. 7, the parallel light beams irradiate onto the reagent film layer 740 of the test paper on the tray body 510, and the reagent film layer 740 absorbs part of the light; the remaining light is reflected to the photodiode 470.

By comparing the difference between the light intensity of the light beam emitted from the LED lamp as the light source and the light intensity of the light beam absorbed by the photodiode 470, the biochemical analyzer 10 converts the corresponding parameter value of the sample to be tested based on the photoelectric colorimetric principle, thereby completing the test of the sample to be tested.

Research shows that the light intensity of the light beam generated by the LED lamp under the same current can be different under different environmental temperatures. To solve this problem, the optical path component 400 of the biochemical analyzer 10 according to the embodiment of the present invention further includes a third heating element 440. The third heating element 440 is made of an aluminum substrate, and a heating circuit and a third temperature sensing element are disposed in the third heating element 440. The third temperature sensing element may employ a temperature probe. The back surface of the third heating element 440 is coated with a thermally conductive silicone, and the third heating element 440 is fixed to the upper surface of the first fixing base 461 through a screw connection element. When the third heating element 440 is powered on to operate, the third heating element 440 heats the first fixing seat 461 and transfers heat to the sleeve and the LED lamp, so that the operating temperature of the optical path assembly 400 is stabilized at about a desired temperature (e.g., 37 ℃), thereby reducing the influence of the ambient temperature on the light intensity of the LED lamp.

Referring to fig. 1, in some embodiments, the housing assembly 100 is an enclosed structure. The shell assembly with the closed structure provides mounting positions for all assemblies inside the shell assembly and isolates external light so as to avoid the influence of the external light on the light path assembly. It should be noted that the enclosure assembly of the closed structure does not mean that all the working components of the biochemical analyzer are completely located inside the enclosure assembly, and some components are located outside the enclosure assembly, so that the requirement of isolating the external light can still be met.

In some embodiments, as shown in FIG. 1, the housing assembly 100 is a box structure. The housing assembly 100 includes a base plate, an upper sealing plate, a right sealing plate, and a left sealing plate (the left sealing plate also serves as a left motor bracket, i.e., the third bracket 210 in fig. 2 to 3), which are connected to the housing through screws to form a stroke-closed box. Fig. 1 also shows that the first wire shaft portion 221 extends out of the housing assembly 100.

In some embodiments, referring to fig. 2-3, the in-out compartment assembly 200 includes a stepper motor 220, a tray adapter element 230, an optocoupler 250, a guide 240, and a bearing 260. The entry and exit module 200 is used to connect the tray assembly 500, and the automatic entry and exit of the tray assembly 500 and the automatic entry are realized. The number of optocouplers 250 is two. The stepping motor 220, the two optical couplers 250, and the guide rail 240 are fixed to the left cover plate (i.e., the third bracket 210) of the housing assembly 100 by a screw coupling member. The stepping motor 220 is provided with a fixed flange seat 223, the stepping motor 220 is further connected with a first screw rod part 221 and a second screw rod part 222, and the first screw rod part 221 and the second screw rod part 222 are coaxial. The guide rail 240 is provided with a guide rail mounting seat 241, three mutually perpendicular surfaces of the tray switching element 230 are mounting surfaces, and the tray switching element 230 is further provided with an optical coupling baffle 270. Three mounting surfaces are designed on the tray adapter element 230, a first mounting surface is fixed on the guide rail mounting base 241 through a threaded connection element, a second mounting surface is fixedly connected with the fixing flange base 223 through a threaded connection element, and the second mounting surface is fixedly connected with the tray assembly 500.

In some embodiments, referring to fig. 4, the biochemical analyzer 10 further includes a scanning assembly 300 and a control unit (not shown), the test strip has encoded information thereon, the scanning assembly 300 is used for scanning the encoded information to identify the type of the test strip and transmitting the type of the test strip to the control unit, and the control unit is used for controlling the on/off state of the light source assembly.

As shown in fig. 4, the scanning assembly 300 includes a scanner 310 and a scanner holder 320. The scanner 310 is fixed to the scanner holder 320 by a screw connection element, and the scanner holder 320 is fixed to the upper sealing plate of the housing assembly 100 by a screw connection element. When the biochemical analyzer is in operation, the scanner 310 scans the coded information (e.g., one-dimensional code) on the test strip, so as to identify the parameter type of the test strip and transmit the parameter type to a control unit (e.g., CPU) of the biochemical analyzer, so as to control the on/off state of the LED lamp.

The code includes at least one of a one-dimensional code, a two-dimensional code, and a three-dimensional code. The three-dimensional code is an array which encodes a binary string obtained by text compilation and image information into a set of interpretable binary strings by a specific algorithm in combination with the overall color content of the picture. The one-dimensional code, the two-dimensional code, and the three-dimensional code are all readable by a machine device, so that the type of the test paper can be identified. Specifically, the code may be a one-dimensional code or a two-dimensional code.

In some embodiments, referring to fig. 8-9, the biochemical analyzer 10 further includes a tray assembly 500. The tray assembly 500 includes a tray body 510, a tray upper cover 511, a tray lower cover 512, a scale fixing cover 532, a first temperature sensing element 521, a first over-temperature protection switch 522, a first heating element 520, and a heat insulation pad 541. The tray body 510 is provided therein with a test paper assembly fixing groove 513 and a calibration material storage groove 531. The target storage groove 531 stores the target 530 therein.

Assembly process of the tray assembly 500: the scale fixing cover 532 fixes the scale 530 into the scale storage groove 531 of the tray body 510 by means of the screw coupling member; the first temperature sensing element 521, the first over-temperature protection switch 522 and the first heating element 520 are coated with heat-conducting silica gel and are respectively assembled to corresponding positions of the tray body 510; the tray upper cover 511 and the tray lower cover 512 are fixed on the tray body 510 through threaded connection elements, and the two integrally wrap the outer surface of the tray body 510, and only the test paper assembly fixing groove 513 is exposed, so as to reduce heat loss; the tray assembly 500 is fixed to the hatch-in and hatch-out assembly 200 by means of screw coupling elements (specifically, fixed to the third mounting surface of the tray transit element 230 by means of screw coupling elements), and a heat insulation pad 541 is provided between the tray body 510 and the tray transit element 230, so that effective thermal insulation is achieved between the tray body 510 and the tray transit element 230, thereby reducing heat loss.

The tray assembly 500 functions to: fixing and heating the lower surface of the strip assembly 700 (heating the tray body 510 to a design temperature by the cooperation of the first heating element 520 and the first temperature sensing element 521, and transferring heat to the lower surface of the strip assembly 700 through the strip assembly fixing grooves 513 of the tray body 510); the calibration object 530 is stored for calibration of the optical path of the biochemical analyzer 10.

In some embodiments, referring to fig. 10-12, the biochemical analyzer 10 further includes a briquetting assembly 600. The compact assembly 600 may be generally divided into a heating mechanism 620, an actuating mechanism 610, a compact body 618, and a second support 612. The heating mechanism 620 generally includes a first bracket 611, a second temperature sensing element 623, a second heating element 621, a second over-temperature protection switch 622, a first bracket upper stationary cover 6111, a first bracket lower stationary cover 6112, and an electromagnet connecting element 617. The second temperature sensing element 623 may employ a temperature probe. The first bracket 611 is provided with a pressing block body 618. The actuating mechanism 610 includes a compression spring 616, a bearing cage 6152, a linear bearing 615, a bearing retainer cap 6151, an electromagnet 613, and a guide shaft 614. The guide shaft 614 includes a guide shaft threaded head 6141.

The assembly process of the compact assembly 600 can be briefly described as follows: (1) the heating mechanism 620: the second temperature sensing element 623, the second heating element 621 and the second over-temperature protection switch 622 are assembled to corresponding positions of the first bracket 611 by coating heat-conducting silica gel; the upper fixing cover 6111 of the first bracket, the lower fixing cover 6112 of the first bracket and the electromagnet connecting element 617 are made of plastic materials, and the three are fixed to the first bracket 611 through threaded connecting elements, so that the heating element is wrapped and the heat insulation effect is achieved, and heat dissipation is prevented.

(2) The actuating mechanism 610: the electromagnet 613 is assembled with a slot of the electromagnet connecting element 617; the bearing fixing cover 6151 fixes the bearing buffer ring 6152 and the linear bearing 615 to the second bracket 612 through a threaded connection element; the guide shaft 614 passes through the linear bearing 615 and the compression spring 616, and the guide shaft 614 is locked to the screw hole of the first bracket 611 through the guide shaft threaded head 6141, so that the guide shaft 614 is communicated with the actuating mechanism 610, and the guide and elastic pressing functions are achieved.

The briquetting assembly 600 functions as follows: the upper surface of the test paper is heated when the whole biochemical analyzer works, and the briquetting assembly 600 is automatically lifted when the cabin entering and exiting assembly 200 works so as to prevent the tray assembly 500 from being damaged.

In some embodiments, referring to fig. 13-14, the biochemical analyzer 10 further includes a test strip assembly 700. Test strip assembly 700 includes a second support element 720, a reagent membrane layer 740, a permeation membrane layer 730, a first support element 710, and an identification code layer 750. The test paper assembly 700 is a laminated structure, and includes a first supporting element 710, a permeable membrane layer 730, a reagent membrane layer 740, and a second supporting element 720 from top to bottom. The first supporting element 710 is provided with a first through hole 711, and the first through hole 711 is used for sample injection; the second support member 720 has a second through hole 721, and the second through hole 721 is for passing light emitted from the optical path component and returning.

The surface of the second supporting member 720 may be divided into a first area and a second area, wherein the first area coincides with the first supporting member 710, and the second supporting member 720 further has a second area beyond the first supporting member 710 and not coinciding. The identification code layer 750 is attached to the second region. Specifically, the identification code layer 750 may be a barcode label layer.

The reagent membrane layer 740 is coated with a different chemical reagent that causes incident light to be partially absorbed by the reagent membrane layer 740, and the unabsorbed incident light is reflected off the strip assembly after reaching the lower surface of the permeable membrane layer 730. An identification code layer 750 is designed on the test paper for distinguishing different test papers.

The operation of the test strip assembly 700 can be briefly described as follows: after the sample to be measured is dropped from the first through hole 711 of the first supporting element 710, the sample to be measured diffuses and permeates through the permeation membrane layer 730 to the whole membrane layer, and a diffuse reflection layer is formed on the lower surface of the permeation membrane layer 730; the light emitted by the LED lamp assembly in the light path assembly is partially absorbed after passing through the reagent film layer 740, and the rest of the light is reflected in the diffuse reflection layer; the reflected light is absorbed by the photodiode after passing through the reagent film layer 740. The degree of light absorption is measured as absorbance, and the correlation formula is: the absorbance is — lg (reflected light/incident light), and the biochemical analyzer 10 calculates a parameter value of the corresponding parameter of the sample to be measured from the absorbance.

In some embodiments, the biochemical analyzer 10 includes the housing assembly 100, the access compartment assembly 200, the scanning assembly 300, the optical path assembly 400, the tray assembly 500, the compact assembly 600, and the test strip assembly 700 described in the previous embodiments. The structure and composition of the above components are not described in detail.

It is understood that the test strip assembly 700 may be provided as a separate component from the biochemical analyzer 10, i.e., in some embodiments, the biochemical analyzer 10 may not include the test strip assembly 700.

The following text will describe the operation of the biochemical analyzer 10 having the above-described components:

(1) the tray assembly 500 is automatically extended (see fig. 15): the electromagnet 613 in the briquetting assembly 600 is electrified to work to drive the heating mechanism 620 to ascend, so that the briquetting body 618 is separated from the surface of the tray assembly 500; the stepping motor 220 of the entrance and exit module 200 works to drive the tray module 500 to extend to a designed position (the optical coupler 250 is used for detecting the movement position of the tray module 500).

(2) A calibration process: the third heating element 440 is electrically operated so that the overall temperature of the optical path assembly 400 is maintained at about 37 ℃; the first LED lamp assembly 410, the second LED lamp assembly 420 and the third LED lamp assembly 430 are respectively turned on, and the emitted light passes through the test paper assembly 700 and then is reflected to the photodiode 470, so that the light intensity of each group of LED lamps can be calibrated.

(3) The placement and sample injection process of the test strip assembly 700: the test strip assembly 700 is placed in the test strip assembly fixing groove 513 of the tray assembly 500, and the liquid of the sample to be tested is dropped into the first through hole 711 of the test strip assembly 700 by using a syringe or a pipette, and the liquid of the sample to be tested is automatically diffused to the whole permeation membrane layer 730.

(4) The tray assembly 500 is automatically retracted: the stepping motor 220 of the entrance and exit module 200 works to drive the tray module 500 to retract to a designed position (the optical coupler 250 is used for detecting the movement position of the tray module 500); the electromagnet 613 in the pressing block assembly 600 is powered off, and the heating mechanism 620 descends under the action of the elastic force of the compression spring 616 and the self gravity, so that the pressing block body 618 presses the upper surface of the test paper assembly 700.

(5) The heating process: the first heating element 520 of the tray assembly 500 is electrically operated to heat the tray body 510; the second temperature sensing element 623 detects the temperature of the tray body 510, and the control unit controls the power of the first heating element 520 to keep the temperature of the tray body 510 at about 37 ℃; heat is transferred to the lower surface of the strip assembly 700 through the strip assembly fixing grooves 513 of the tray body 510.

When the temperature of the tray body 510 is too high, the first over-temperature protection switch 522 automatically de-energizes the first heating element 520 to avoid damaging the tray assembly 500; the second heating element 621 of the briquette assembly 600 is electrically operated to heat the first support 611; under the cooperative action of the second temperature sensing element 623 and the second over-temperature protection switch 622, the temperature of the first support 611 is maintained at about 37 ℃, thereby heating the upper surface of the test strip assembly 700.

By heating the upper and lower surfaces on both sides, the test strip assembly 700 can be heated and kept at about 37 ℃, thereby reducing the influence of the ambient temperature on the test result.

(6) The test procedure: after the tray assembly 500 is retracted to the design position (the optical coupler 250 is used to detect the movement position of the tray assembly 500), the scanner 310 is powered on. The scanner 310 scans and transmits encoded information (e.g., one-dimensional code) on the test strip assembly 700 to the control unit. The control unit identifies the type of the test paper assembly 700 to be tested through the coded information and controls the corresponding LED lamp to be electrified and operated.

The light emitted by the LED lamp assembly in the light path assembly is partially absorbed after passing through the reagent film layer 740, and the rest of the light is reflected in the diffuse reflection layer; the reflected light is absorbed by the photodiode after passing through the reagent film layer 740. The degree of light absorption is measured as absorbance, and the correlation formula is: the absorbance is — lg (reflected light/incident light), and the biochemical analyzer 10 calculates a parameter value of the corresponding parameter of the sample to be measured from the absorbance.

The biochemical analyzer 10 of the present embodiment has at least the following technical effects:

(1) the upper surface and the lower surface of the test paper assembly 700 are heated, so that the test paper is rapidly heated and is kept at a constant temperature of about 37 ℃;

(2) the rear end of the tray assembly 500 is provided with a calibration object 530, and during the process of placing the test paper assembly 700 and sample injection, the light intensity of each group of LED lamps of the light source assembly 400 can be calibrated;

(3) the third heating element 440 in the optical path assembly 400 can heat the LED lamp assembly and the like, so that the LED lamp assembly is thermostated to about 37 ℃, thereby reducing the influence of the change of the ambient temperature on the test result;

(4) the biochemical analyzer 10 has a simple structure, reliable test results, short test time and low cost. The entire biochemical analyzer 10 does not require a complicated liquid path structure nor a complicated heat insulating structure. Moreover, the testing process is highly automated-the user only needs to put test paper and complete sample injection, and the subsequent testing can be automatically completed by the biochemical analyzer 10.

The embodiment of the utility model provides an LED lamp and a photodiode that have three kinds of different wavelength in biochemical analyzer's the light path subassembly adopts and measures GLU (glucose), TP (total protein), AST (aspartate aminotransferase), GGT (glutamine aminotransferase), CHE (cholinesterase) and different parameters such as CREA (creatinine) in the body fluid (containing trace whole blood, plasma, serum or urine etc.) based on lambert's proportion theory of absorption's photoelectricity colorimetric principle.

While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims (10)

1. A biochemical analyzer for performing an analytical test on a sample to be tested on a test strip, the biochemical analyzer comprising:

the test paper detection device comprises a light path component, a heating element and a temperature sensing element, wherein the light path component comprises a light source component, the heating element and the temperature sensing element, the light source component is used for emitting light rays to irradiate the test paper, the heating element is used for transferring generated heat to the light source component, and the temperature sensing element is used for detecting the temperature of the light source component; and

a housing assembly, the optical path assembly located within the housing assembly.

2. The biochemical analyzer according to claim 1, wherein the optical assembly further comprises a first fixing base, the light source assembly and the heating element are mounted on the first fixing base, and a surface of the heating element has a thermally conductive silicone.

3. The biochemical analyzer of claim 1, wherein the heating element comprises an aluminum substrate material.

4. The biochemical analyzer of claim 2, further comprising a control unit, the heating element having a heating circuit, both the heating circuit and the temperature sensing element being electrically connected to the control unit.

5. The biochemical analyzer according to claim 2, further comprising a control unit, the light source assemblies including a first LED light assembly having a wavelength of 405nm, a second LED light assembly having a wavelength of 550nm, and a third LED light assembly having a wavelength of 610nm, the control unit controlling switching of an on state and an off state of at least one of the first LED light assembly, the second LED light assembly, and the third LED light assembly.

6. The biochemical analyzer according to claim 5, wherein the light source assembly comprises an LED lamp assembly including an LED lamp, a sleeve, and a convex mirror, the LED lamp is mounted in the sleeve, the convex mirror is mounted at one end of the sleeve, the sleeve is provided with a light-transmitting hole, and light from the LED lamp can penetrate through the light-transmitting hole and enter the surface of the convex mirror.

7. The biochemical analyzer according to claim 6, wherein the LED lamp assembly further comprises a PCBA board electrically connected to the LED lamp, the PCBA board being mounted to the other end of the sleeve.

8. The biochemical analyzer according to claim 6, wherein the optical path assembly further comprises a photodiode, the photodiode is mounted below the first fixing base, and the photodiode is configured to receive light reflected by the test paper after the light from the LED lamp is emitted to the test paper.

9. The biochemical analyzer according to claim 1, further comprising a scanning component and a control unit, wherein the test strip has encoded information thereon, the scanning component is configured to scan the encoded information to identify a type of the test strip and transmit the type of the test strip to the control unit, and the control unit is configured to control an on/off state of the light source component.

10. The biochemical analyzer of any one of claims 1-9, wherein the housing assembly is an enclosed structure.

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