CN112033919A - Biochemical analyzer - Google Patents

Abstract

The invention discloses a biochemical analyzer. The biochemical analyzer is used for analyzing and testing a sample to be tested on the test paper. The biochemical analyzer comprises a pressing block assembly, a tray assembly and a shell assembly. The pressing block assembly comprises a pressing block body and an actuating mechanism, the pressing block body is used for pressing the upper part of the test paper to fix the test paper, and the actuating mechanism can drive the pressing block body to move up and down; the tray assembly comprises a tray body, and the tray body is used for supporting the test paper from the lower part of the test paper; the pressing block assembly is located in the shell assembly, and the tray assembly can extend out of the shell assembly. The briquetting component in the biochemical analyzer can automatically lift the test paper and automatically fall to compress the test paper, so that the degree of automation is high.

Description

Biochemical analyzer

Technical Field

The invention relates to the technical field of analysis and test, in particular to a biochemical analyzer.

Background

A biochemical analyzer, also called biochemical analyzer, is a biochemical detection device for detecting and feeding back multiple samples or multiple items. The detection principle of the biochemical analyzer is to detect a certain characteristic chemical component in a sample based on the photoelectric colorimetric principle. The biochemical analyzer has the advantages of high detection speed, high accuracy, low consumption of dosage and the like, and is widely applied to places such as hospitals, epidemic prevention stations, quarantine stations and the like. However, the current biochemical instruments have low automation degree, resulting in slower detection speed.

Disclosure of Invention

The invention mainly aims to provide a biochemical analyzer which has the advantage of higher automation degree.

The embodiment of the invention provides a biochemical analyzer. The biochemical analyzer is used for analyzing and testing a sample to be tested on the test paper. The biochemical analyzer includes:

the pressing block assembly comprises a pressing block body and an actuating mechanism, the pressing block body is used for pressing the upper part of the test paper to fix the test paper, and the actuating mechanism can drive the pressing block body to move up and down;

the tray assembly comprises a tray body, and the tray body is used for supporting the test paper from the lower part of the test paper; and

the pressing block assembly is located in the shell assembly, and the tray assembly can extend out of the shell assembly.

The pressing block body above the test paper can be automatically lifted to leave the surface of the test paper under the action of the actuating mechanism, so that the automation degree of the whole biochemical analyzer is improved.

In some embodiments, the biochemical analyzer includes a control unit, the actuating mechanism includes an electromagnet, a first bracket and a second bracket, the control unit is configured to control switching between an energized state and a de-energized state of the electromagnet, the electromagnet is capable of generating a lifting motion in the energized state, the electromagnet and the pressing block body are both fixedly connected to the first bracket, and the second bracket is fixedly connected to the housing assembly.

After the electromagnet is electrified, under the action of the electromagnetic force, the electromagnet can rise, so that the briquetting body can also rise. Under the state of electro-magnet outage, under the effect of self gravity, electro-magnet self can fall for the briquetting body also can fall thereupon.

In some embodiments, the actuating mechanism further includes a guide shaft and a linear bearing, the guide shaft passes through the linear bearing, the linear bearing is fixedly connected with the second bracket, and the guide shaft is fixedly connected with the first bracket.

The guide shaft is matched with the linear bearing, so that the motion of the whole actuating mechanism is always linear motion, and the service life of the actuating mechanism is prolonged.

In some embodiments, the actuating mechanism further comprises a compression spring, and the compression spring is sleeved on the guide shaft.

The compression spring provides a cushioning effect for the actuating mechanism, so that the pressing block assembly can be lifted off and dropped to the surface of the test paper assembly relatively smoothly.

In some embodiments, the electromagnet is fixedly connected to the first bracket through an electromagnet connecting element, and the electromagnet connecting element comprises a plastic material. The electromagnet connecting element made of plastic has the functions of heat insulation and insulation, so that heat loss is prevented, and corresponding electric elements can be protected from short circuit.

In some embodiments, the biochemical analyzer further includes an in-out compartment assembly, the in-out compartment assembly includes a third bracket, a motor, a tray adapter element, and a guide rail, the tray adapter element is fixedly connected to the tray body, the motor and the guide rail are both mounted on the third bracket, an output end of the motor and the tray adapter element form a transmission connection through a screw-nut pair, and the tray connecting element can move along the guide rail.

By means of the screw-nut pair, the rotation of the output shaft of the motor can cause the linear displacement of the tray switching element, so that the tray body generates linear motion, namely the in-and-out cabin motion of the tray body.

In some embodiments, the entry and exit module further comprises a position detection element for detecting a movement position of the tray changeover element. The position detecting element can prevent the tray body from exceeding the maximum stroke.

In some embodiments, the position detecting element includes a first position detecting element and a second position detecting element, the first position detecting element and the second position detecting element are both mounted on the third bracket, the first position detecting element is configured to detect a movement position of the tray adapter element when the screw of the screw-nut pair rotates forward, and the second position detecting element is configured to detect a movement position of the tray adapter element when the screw of the screw-nut pair rotates backward. Two position detection elements for detecting the movement positions in the positive direction and the negative direction are arranged respectively, so that the tray body does not exceed the corresponding maximum stroke when extending out of the shell assembly and retracting into the shell assembly.

In some embodiments, the first position detecting element and the second position detecting element are both optical couplers, and the tray connecting element is further provided with an optical coupler blocking sheet. The optical coupler blocking piece in the motion state is used for opening or closing the optical coupler, so that the optical coupler is matched with the optical coupler to detect the motion position of the tray connecting element.

In some embodiments, the biochemical analyzer further comprises an optical path component comprising a first LED lamp component having a wavelength of 405nm, a second LED lamp component having a wavelength of 550nm, and a third LED lamp component having a wavelength of 610 nm. The biochemical analyzer in this embodiment includes three different wavelengths, enriching the testable objects of the biochemical analyzer.

Drawings

FIG. 1 is a schematic structural diagram of a housing assembly in an embodiment of the invention;

FIG. 2 is a schematic assembly view of the entry and exit assembly according to an embodiment of the present invention;

FIG. 3 is an exploded view of the hatch assembly in an embodiment of the present invention;

FIG. 4 is a schematic structural diagram of a scanning assembly according to an embodiment of the present invention;

FIG. 5 is a schematic diagram of an assembly structure of an optical circuit assembly according to an embodiment of the present invention;

FIG. 6 is an exploded view of an optical circuit assembly according to an embodiment of the present invention;

FIG. 7 is a cross-sectional view of an optical circuit assembly in an embodiment of the present invention;

FIG. 8 is a schematic diagram of an assembly structure of the tray assembly according to an embodiment of the present invention;

FIG. 9 is an exploded view of the tray assembly in an embodiment of the present invention;

FIG. 10 is a schematic diagram of an assembly structure of a pressure block assembly according to an embodiment of the present invention;

FIG. 11 is a cross-sectional view of a compact assembly in an embodiment of the invention;

FIG. 12 is an exploded view of the housing assembly in an embodiment of the present invention;

FIG. 13 is an exploded view of the test strip assembly in an embodiment of the present invention;

FIG. 14 is a schematic diagram (top view) illustrating an assembly structure of the test strip assembly according to an embodiment of the present invention;

fig. 15 is a schematic structural view of the tray assembly extending out of the housing assembly in the embodiment of the present invention.

Reference numerals:

10-a biochemical analyzer;

100-a housing assembly;

200-an in-out cabin assembly; 210-a third scaffold; 220-a step motor; 221-a first screw part, 222-a second screw part, 223-a fixed flange seat; 230-tray changeover elements; 240-guide rail, 241-guide rail mounting seat; 250-optical couplers; 260-a bearing; 270-optical coupling baffle plate;

300-a scanning component, 310-a scanner, 320-a scanner holder;

400-an optical path component; 410-a first LED lamp assembly, 411-a first LED lamp, 412-a first sleeve, 413-a first convex mirror, 414-a first PCBA board, 415-a first convex mirror fixed cover; 420-a second LED lamp assembly; 430-a third LED lamp assembly; 440-a third heating element; 461-first fixed seat; 470-a photodiode;

500-a tray assembly; 510-a tray body, 511-a tray upper cover, 512-a tray lower cover and 513-a test paper component fixing groove; 520-a first heating element, 521-a first temperature sensing element; 522-first over-temperature protection switch; 530-calibration object, 531-calibration object storage tank and 532-calibration object fixing cover; 541-a heat insulation pad;

600-a briquetting assembly; 610-an actuation mechanism; 611-a first bracket, 6111-a first bracket upper fixing cover, 6112-a first bracket lower fixing cover; 612-a second bracket; 613-an electromagnet; 614-guide shaft, 6141-guide shaft thread head; 615-linear bearing, 6151-bearing fixing cover, 6152-bearing buffer ring; 616-a compression spring; 617-an electromagnet connecting element; 618-briquetting body; 620-a heating mechanism; 621-a second heating element; 622-second over-temperature protection switch; 623-a second temperature sensing element;

700-test paper assembly; 710-first support element, 711-first through hole; 720-second support element, 721-second through hole; 730-a permeate membrane layer; 740-a reagent film layer; 750-identification code layer.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention. The technical solutions between the embodiments of the present invention may be combined with each other, but should be based on the realization of those skilled in the art.

In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", and "left", "right", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the term "connected" is to be interpreted broadly, and may be, for example, a fixed connection and a movable connection, a detachable connection and a non-detachable connection, or an integral connection; may be mechanically or electrically connected or may be in communication with each other. And "fixedly connected" includes detachably connected, non-detachably connected, integrally connected, and the like.

In the present invention, references to terms like "first" or "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. In the present invention, references to the like "vertical" and "horizontal" do not refer to absolute vertical and absolute horizontal only, but also include generally vertical and generally horizontal as is acceptable in the art.

The embodiment of the invention provides a biochemical analyzer. Referring to fig. 1 to 15, the biochemical analyzer 10 includes a housing assembly 100 (shown in fig. 1), a tray assembly 500 (shown in fig. 8 to 9), and a pressure block assembly 600 (shown in fig. 10 to 12).

The compact assembly 600 is located within the housing assembly 100 and the tray assembly 500 can extend out of the housing assembly 100.

The pressing block assembly 600 comprises a pressing block body 618 and an actuating mechanism 610, the pressing block body 618 is used for pressing the upper part of the test paper to fix the test paper, and the actuating mechanism 610 can drive the pressing block body 618 to move up and down; the tray assembly 500 includes a tray body 510 for supporting the test strips from below.

The pressing block body above the test paper can be automatically lifted to leave the surface of the test paper under the action of the actuating mechanism, so that the automation degree of the whole biochemical analyzer is improved.

In some embodiments, referring to fig. 8 to 9, the tray assembly 500 includes a tray body 510, a tray upper cover 511, a tray lower cover 512, a target fixing cover 532, a first temperature sensing element 521, a first over-temperature protection switch 522, a first heating element 520, and a heat insulation pad 541. The tray body 510 is provided therein with a test paper assembly fixing groove 513 and a calibration material storage groove 531. The target storage groove 531 stores the target 530 therein.

Assembly process of the tray assembly 500: the scale fixing cover 532 fixes the scale 530 into the scale storage groove 531 of the tray body 510 by means of the screw coupling member; the first temperature sensing element 521, the first over-temperature protection switch 522 and the first heating element 520 are coated with heat-conducting silica gel and are respectively assembled to corresponding positions of the tray body 510; the tray upper cover 511 and the tray lower cover 512 are fixed on the tray body 510 through threaded connection elements, and the two integrally wrap the outer surface of the tray body 510, and only the test paper assembly fixing groove 513 is exposed, so as to reduce heat loss; the tray assembly 500 is fixed to the hatch-in and hatch-out assembly 200 by means of screw coupling elements (specifically, fixed to the third mounting surface of the tray transit element 230 by means of screw coupling elements), and a heat insulation pad 541 is provided between the tray body 510 and the tray transit element 230, so that effective thermal insulation is achieved between the tray body 510 and the tray transit element 230, thereby reducing heat loss.

The tray assembly 500 functions to: fixing and heating the lower surface of the strip assembly 700 (heating the tray body 510 to a design temperature by the cooperation of the first heating element 520 and the first temperature sensing element 521, and transferring heat to the lower surface of the strip assembly 700 through the strip assembly fixing grooves 513 of the tray body 510); the calibration object 530 is stored for calibration of the optical path of the biochemical analyzer 10.

In some embodiments, referring to fig. 10-12, the biochemical analyzer 10 includes a control unit (not shown), the actuating mechanism 610 includes an electromagnet 613, a first bracket 611, and a second bracket 612; the control unit is used for controlling the switching between the power-on state and the power-off state of the electromagnet 613, the electromagnet 613 can generate a lifting motion in the power-on state, the electromagnet 613 and the pressing block body 618 are both fixedly connected with the first bracket 611, and the second bracket 612 is fixedly connected with the housing assembly 100.

When electromagnet 613 is energized, electromagnet 613 itself can be raised by the action of electromagnetic force to lift first holder 611, and pressing block body 618 can be raised even when electromagnet 613 is energized. In a state where electromagnet 613 is deenergized, electromagnet 613 can fall by its own weight, and press body 618 can also fall along with it.

In some embodiments, with continued reference to fig. 10-12, the electromagnet 613 is fixedly connected to the first support 611 via an electromagnet connecting element 617, and the electromagnet connecting element 617 comprises a plastic material. The electromagnet connecting element 617 made of plastic has heat insulation and insulation effects, so as to prevent heat loss and protect corresponding electrical elements from short circuit.

In some embodiments, with continued reference to fig. 10 to 12, the actuating mechanism 610 further includes a guide shaft 614 and a linear bearing 615, the guide shaft 614 passes through the linear bearing 615, the linear bearing 615 is fixedly connected to the second bracket 612, and the guide shaft 614 is fixedly connected to the first bracket 611.

The electromagnet 613 and the guide shaft 614 are both fixedly connected to the first bracket 611, so that the electromagnet 613 can drive the guide shaft 614 to move up and down. The guide shaft 614 cooperates with the linear bearing 615 to ensure that the entire actuator mechanism 610 is always moving linearly, thereby extending the operating life of the actuator mechanism 610.

In some embodiments, with continued reference to fig. 10 to 12, the actuating mechanism 610 further includes a compression spring 616, and the compression spring 616 is sleeved on the guide shaft 614. The compression spring 616 provides a cushioning effect for the actuation mechanism 610, thereby enabling the mass assembly 600 to lift off and fall to the surface of the test strip assembly relatively smoothly.

In some embodiments, referring to fig. 10-12, the compact assembly 600 may be generally divided into a heating mechanism 620, an actuating mechanism 610, a compact body 618, and a second support 612. The heating mechanism 620 generally includes a first bracket 611, a second temperature sensing element 623, a second heating element 621, a second over-temperature protection switch 622, a first bracket upper stationary cover 6111, a first bracket lower stationary cover 6112, and an electromagnet connecting element 617. The second temperature sensing element 623 may employ a temperature probe. The first bracket 611 is provided with a pressing block body 618. The actuating mechanism 610 includes a compression spring 616, a bearing cage 6152, a linear bearing 615, a bearing retainer cap 6151, an electromagnet 613, and a guide shaft 614. The guide shaft 614 includes a guide shaft threaded head 6141.

The assembly process of the compact assembly 600 can be briefly described as follows: (1) the heating mechanism 620: the second temperature sensing element 623, the second heating element 621 and the second over-temperature protection switch 622 are assembled to corresponding positions of the first bracket 611 by coating heat-conducting silica gel; the upper fixing cover 6111 of the first bracket, the lower fixing cover 6112 of the first bracket and the electromagnet connecting element 617 are made of plastic materials, and the three are fixed to the first bracket 611 through threaded connecting elements, so that the heating element is wrapped and the heat insulation effect is achieved, and heat dissipation is prevented.

(2) The actuating mechanism 610: the electromagnet 613 is assembled with a slot of the electromagnet connecting element 617; the bearing fixing cover 6151 fixes the bearing buffer ring 6152 and the linear bearing 615 to the second bracket 612 through a threaded connection element; the guide shaft 614 passes through the linear bearing 615 and the compression spring 616, and the guide shaft 614 is locked to the screw hole of the first bracket 611 through the guide shaft threaded head 6141, so that the guide shaft 614 is communicated with the actuating mechanism 610, and the guide and elastic pressing functions are achieved.

The briquetting assembly 600 functions as follows: the upper surface of the test paper is heated when the whole biochemical analyzer works, and the briquetting assembly 600 is automatically lifted when the cabin entering and exiting assembly 200 works so as to prevent the tray assembly 500 from being damaged.

In some embodiments, with continued reference to fig. 10 to 12, the biochemical analyzer 10 further includes an in-out chamber assembly 200, the in-out chamber assembly 200 includes a third bracket 210, a motor, a tray adapter 230, and a guide rail 240, the tray adapter 230 is fixedly connected to the tray body 510, the motor and the guide rail 240 are both mounted on the third bracket 210, an output end of the motor is in transmission connection with the tray adapter 230 via a screw-nut pair, and the tray connecting element 230 can move along the guide rail 240. Specifically, as shown in fig. 1 to 14, the motor is a stepping motor 220.

By means of the screw nut pair, the rotation of the motor output shaft can cause the linear displacement of the tray changeover member 230, so that the tray body 510 generates the linear movement, i.e., the in-and-out movement of the tray body.

In some embodiments, referring to fig. 2 to 3, the hatch-in assembly 200 further includes a position detection element for detecting a movement position of the tray adapter element 230. The position detecting element can prevent the tray body from exceeding the maximum stroke.

In some embodiments, the position detecting elements include a first position detecting element and a second position detecting element, both of which are mounted on the third bracket 210, and the first position detecting element is used for detecting the moving position of the tray switching element 230 when the screw of the screw-nut pair is rotated forward, and the second position detecting element is used for detecting the moving position of the tray switching element 230 when the screw of the screw-nut pair is rotated backward. Two position detection elements for detecting the movement positions in the positive direction and the negative direction are arranged respectively, so that the tray body does not exceed the corresponding maximum stroke when extending out of the shell assembly and retracting into the shell assembly.

In some embodiments, referring to fig. 2 to fig. 3, the first position detecting element and the second position detecting element are both an optical coupler 250, and the tray connecting element 230 is further provided with an optical coupler blocking sheet 270. An optical coupler, abbreviated as an optocoupler, is a device for transmitting electrical signals by using light as a medium. The optical coupler is used for detecting the position and has the advantages of small size, long service life, no contact, strong anti-interference capability, insulation between output and input, unidirectional signal transmission and the like. When the input end of the optical coupler is electrified with a signal, the light emitter emits light, the light receiver receives the light and then generates light current, and the light current flows out from the output end of the optical coupler, so that the electro-optic conversion is realized. The optical coupler blocking piece in the motion state is used for opening or closing the optical coupler, so that the optical coupler is matched with the optical coupler to detect the motion position of the tray connecting element.

In some embodiments, referring to fig. 2-3, the in-out compartment assembly 200 includes a stepper motor 220, a tray adapter element 230, an optocoupler 250, a guide 240, and a bearing 260. The entry and exit module 200 is used to connect the tray assembly 500, and the automatic entry and exit of the tray assembly 500 and the automatic entry are realized. The number of optocouplers 250 is two. The stepping motor 220, the two optical couplers 250, and the guide rail 240 are fixed to the left cover plate (i.e., the third bracket 210) of the housing assembly 100 by a screw coupling member. The stepping motor 220 is provided with a fixed flange seat 223, the stepping motor 220 is further connected with a first screw rod part 221 and a second screw rod part 222, and the first screw rod part 221 and the second screw rod part 222 are coaxial. The guide rail 240 is provided with a guide rail mounting seat 241, three mutually perpendicular surfaces of the tray switching element 230 are mounting surfaces, and the tray switching element 230 is further provided with an optical coupling baffle 270. Three mounting surfaces are designed on the tray adapter element 230, a first mounting surface is fixed on the guide rail mounting base 241 through a threaded connection element, a second mounting surface is fixedly connected with the fixing flange base 223 through a threaded connection element, and the second mounting surface is fixedly connected with the tray assembly 500.

In some embodiments, referring to fig. 1, the biochemical analyzer further includes a housing assembly 100. The housing assembly 100 is a box structure. The housing assembly 100 includes a base plate, an upper sealing plate, a right sealing plate, and a left sealing plate (the left sealing plate also serves as a left motor bracket, i.e., the third bracket 210 in fig. 2 to 3), which are connected to the housing through screws to form a stroke-closed box. Fig. 1 also shows that the first wire shaft portion 221 extends out of the housing assembly 100.

In some embodiments, biochemical analyzer 10 further includes a scanning assembly 300. As shown in fig. 4, the scanning assembly 300 includes a scanner 310 and a scanner holder 320. The scanner 310 is fixed to the scanner holder 320 by a screw connection element, and the scanner holder 320 is fixed to the upper sealing plate of the housing assembly 100 by a screw connection element. When the biochemical analyzer is in operation, the scanner 310 scans the coded information (e.g., one-dimensional code) on the test strip, so as to identify the parameter type of the test strip and transmit the parameter type to a control unit (e.g., CPU) of the biochemical analyzer, so as to control the on/off state of the LED lamp.

In some embodiments, referring to fig. 5-7, the biochemical analyzer 10 further includes an optical path component 400. The optical path component 400 is used as a core component of the biochemical analyzer 10, and is used for realizing the test of the test paper based on the photoelectric colorimetric principle. As shown in fig. 5 to 7, the light path assembly 400 includes a first LED lamp assembly 410 (wavelength of 405nm), a second LED lamp assembly 420 (wavelength of 550nm), a third LED lamp assembly 430 (wavelength of 610nm), a third heating element 440, a photodiode 470 and a first fixing base 461 (made of aluminum substrate).

Different sample components to be tested have specific wavelengths respectively, and the absorbance at the specific wavelength is usually in positive correlation with the concentration of the component, so that the concentration of various components needs to be tested and analyzed by adopting different wavelengths. The biochemical analyzer in the embodiment of the invention comprises three different wavelengths, so that the testable objects of the biochemical analyzer are enriched.

Each of the components of the optical circuit assembly 400 is fixed to the first fixing base 461 by a screw connection member. The first LED lamp assembly 410, the second LED lamp assembly 420, and the third LED lamp assembly 430 are identical in structure. Taking the first LED lamp assembly 410 as an example, the first LED lamp assemblies 410 each include a first LED lamp 411, a first sleeve 412, a first convex mirror 413, a first convex mirror fixing cover 415, and a first PCBA board 414. The first sleeve 412 is made of aluminum base material, and the first sleeve 412 has a light hole therein.

The operation of the optical path assembly 400 can be briefly described as follows: after the biochemical analyzer 10 identifies the type of the test paper through the scanning component 300, the corresponding LED lamp is controlled to be powered on. As shown in fig. 7, taking the first LED lamp assembly 410 as an example, light generated by the LED lamp is transmitted through the light-transmitting hole of the first sleeve 412 to irradiate the surface of the first convex mirror 413, and is refracted along the first convex mirror 413 to generate a parallel light beam. In fig. 7, the direction of the arrow indicates the direction of the optical path. As shown in fig. 7, the parallel light beam irradiates the test paper reagent film layer 740 on the tray body 510, and the reagent film layer 740 absorbs a part of the light; the remaining light is reflected to the photodiode 470.

By comparing the difference between the light intensity of the light beam emitted from the LED lamp as the light source and the light intensity of the light beam absorbed by the photodiode 470, the biochemical analyzer 10 converts the corresponding parameter value of the sample to be tested based on the photoelectric colorimetric principle, thereby completing the test of the sample to be tested.

Research shows that the light intensity of the light beam generated by the LED lamp under the same current can be different under different environmental temperatures. To solve this problem, the optical path component 400 of the biochemical analyzer 10 in the embodiment of the present invention further designs a third heating element 440. The third heating element 440 is made of an aluminum substrate, and a heating circuit and a third temperature sensing element (not shown) are disposed in the third heating element 440. The third temperature sensing element may employ a temperature probe. The back surface of the third heating element 440 is coated with a thermally conductive silicone, and the third heating element 440 is fixed to the upper surface of the first fixing base 461 through a screw connection element. When the third heating element 440 is powered on to operate, the third heating element 440 heats the first fixing seat 461 and transfers heat to the sleeve and the LED lamp, so that the operating temperature of the optical path assembly 400 is stabilized at about a desired temperature (e.g., 37 ℃), thereby reducing the influence of the ambient temperature on the light intensity of the LED lamp.

In some embodiments, referring to fig. 13-14, the biochemical analyzer 10 further includes a test strip assembly 700. Test strip assembly 700 includes a second support element 720, a reagent membrane layer 740, a permeation membrane layer 730, a first support element 710, and an identification code layer 750. The test paper assembly 700 is a laminated structure, and includes a first supporting element 710, a permeable membrane layer 730, a reagent membrane layer 740, and a second supporting element 720 from top to bottom. The first supporting element 710 is provided with a first through hole 711, and the first through hole 711 is used for sample injection; the second support member 720 has a second through hole 721, and the second through hole 721 is for passing light emitted from the optical path component and returning.

The surface of the second supporting member 720 may be divided into a first area and a second area, wherein the first area coincides with the first supporting member 710, and the second supporting member 720 further has a second area beyond the first supporting member 710 and not coinciding. The identification code layer 750 is attached to the second region. Specifically, the identification code layer 750 may be a barcode label layer.

The reagent membrane layer 740 is coated with a different chemical reagent that causes incident light to be partially absorbed by the reagent membrane layer 740, and the unabsorbed incident light is reflected off the strip assembly after reaching the lower surface of the permeable membrane layer 730. An identification code layer 750 is designed on the test paper for distinguishing different test papers.

The operation of the test strip assembly 700 can be briefly described as follows: after the sample to be measured is dropped from the first through hole 711 of the first supporting element 710, the sample to be measured diffuses and permeates through the permeation membrane layer 730 to the whole membrane layer, and a diffuse reflection layer is formed on the lower surface of the permeation membrane layer 730; the light emitted by the LED lamp assembly in the light path assembly is partially absorbed after passing through the reagent film layer 740, and the rest of the light is reflected in the diffuse reflection layer; the reflected light is absorbed by the photodiode after passing through the reagent film layer 740. The degree of light absorption is measured as absorbance, and the correlation formula is: the absorbance is — lg (reflected light/incident light), and the biochemical analyzer 10 calculates a parameter value of the corresponding parameter of the sample to be measured from the absorbance.

In some embodiments, the biochemical analyzer 10 includes the housing assembly 100, the entry and exit chamber assembly 200, the scanning assembly 300, the optical path assembly 400, the tray assembly 500, the compact assembly 600, and the test strip assembly 700 described in the previous embodiments. The structure and composition of the above components are not described in detail.

It is understood that the test strip assembly 700 may be provided as a separate component from the biochemical analyzer 10, i.e., in some embodiments, the biochemical analyzer 10 may not include the test strip assembly 700.

The following text will describe the operation of the biochemical analyzer 10 having the above-described components:

(1) the tray assembly 500 is automatically extended (see fig. 15): the electromagnet 613 in the briquetting assembly 600 is electrified to work to drive the heating mechanism 620 to ascend, so that the briquetting body 618 is separated from the surface of the tray assembly 500; the stepping motor 220 of the entrance and exit module 200 works to drive the tray module 500 to extend to a designed position (the optical coupler 250 is used for detecting the movement position of the tray module 500).

(2) A calibration process: the third heating element 440 is electrically operated so that the overall temperature of the optical path assembly 400 is maintained at about 37 ℃; the first LED lamp assembly 410, the second LED lamp assembly 420 and the third LED lamp assembly 430 are respectively turned on, and the emitted light passes through the test paper assembly 700 and then is reflected to the photodiode 470, so that the light intensity of each group of LED lamps can be calibrated.

(3) The placement and sample injection process of the test strip assembly 700: the test strip assembly 700 is placed in the test strip assembly fixing groove 513 of the tray assembly 500, and the liquid of the sample to be tested is dropped into the first through hole 711 of the test strip assembly 700 by using a syringe or a pipette, and the liquid of the sample to be tested is automatically diffused to the whole permeation membrane layer 730.

(4) The tray assembly 500 is automatically retracted: the stepping motor 220 of the entrance and exit module 200 works to drive the tray module 500 to retract to a designed position (the optical coupler 250 is used for detecting the movement position of the tray module 500); the electromagnet 613 in the pressing block assembly 600 is powered off, and the heating mechanism 620 descends under the action of the elastic force of the compression spring 616 and the self gravity, so that the pressing block body 618 presses the upper surface of the test paper assembly 700.

(5) The heating process: the first heating element 520 of the tray assembly 500 is electrically operated to heat the tray body 510; the second temperature sensing element 623 detects the temperature of the tray body 510, and the control unit controls the power of the first heating element 520 to keep the temperature of the tray body 510 at about 37 ℃; heat is transferred to the lower surface of the strip assembly 700 through the strip assembly fixing grooves 513 of the tray body 510.

When the temperature of the tray body 510 is too high, the first over-temperature protection switch 522 automatically de-energizes the first heating element 520 to avoid damaging the tray assembly 500; the second heating element 621 of the briquette assembly 600 is electrically operated to heat the first support 611; under the cooperative action of the second temperature sensing element 623 and the second over-temperature protection switch 622, the temperature of the first support 611 is maintained at about 37 ℃, thereby heating the upper surface of the test strip assembly 700.

By heating the upper and lower surfaces on both sides, the test strip assembly 700 can be heated and kept at about 37 ℃, thereby reducing the influence of the ambient temperature on the test result.

(6) The test procedure: after the tray assembly 500 is retracted to the design position (the optical coupler 250 is used to detect the movement position of the tray assembly 500), the scanner 310 is powered on. The scanner 310 scans and transmits encoded information (e.g., one-dimensional code) on the test strip assembly 700 to the control unit. The control unit identifies the type of the test paper assembly 700 to be tested through the coded information and controls the corresponding LED lamp to be electrified and operated.

The light emitted by the LED lamp assembly in the light path assembly is partially absorbed after passing through the reagent film layer 740, and the rest of the light is reflected in the diffuse reflection layer; the reflected light is absorbed by the photodiode after passing through the reagent film layer 740. The degree of light absorption is measured as absorbance, and the correlation formula is: the absorbance is — lg (reflected light/incident light), and the biochemical analyzer 10 calculates a parameter value of the corresponding parameter of the sample to be measured from the absorbance.

The biochemical analyzer 10 of the present embodiment has at least the following technical effects:

(1) the upper surface and the lower surface of the test paper assembly 700 are heated, so that the test paper is rapidly heated and is kept at a constant temperature of about 37 ℃;

(2) the rear end of the tray assembly 500 is provided with a calibration object 530, and during the process of placing the test paper assembly 700 and sample injection, the light intensity of each group of LED lamps of the light source assembly 400 can be calibrated;

(3) the third heating element 440 in the optical path assembly 400 can heat the LED lamp assembly and the like, so that the LED lamp assembly is thermostated to about 37 ℃, thereby reducing the influence of the change of the ambient temperature on the test result;

(4) the biochemical analyzer 10 has a simple structure, reliable test results, short test time and low cost. The entire biochemical analyzer 10 does not require a complicated liquid path structure nor a complicated heat insulating structure. Moreover, the testing process is highly automated-the user only needs to put test paper and complete sample injection, and the subsequent testing can be automatically completed by the biochemical analyzer 10.

The light path component of the biochemical analyzer in the embodiment of the invention is provided with three LED lamps with different wavelengths and a photodiode, and adopts a photoelectric colorimetric principle based on the Lambert beer absorption theory to measure different parameters such as GLU (glucose), TP (total protein), AST (aspartate aminotransferase), GGT (glutamine aminotransferase), CHE (cholinesterase) and CREA (creatinine) in body fluid (containing trace whole blood, plasma, serum or urine).

While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims (10)

1. A biochemical analyzer for performing an analytical test on a sample to be tested on a test strip, the biochemical analyzer comprising:

the pressing block assembly comprises a pressing block body and an actuating mechanism, the pressing block body is used for pressing the upper part of the test paper to fix the test paper, and the actuating mechanism can drive the pressing block body to move up and down;

the tray assembly comprises a tray body, and the tray body is used for supporting the test paper from the lower part of the test paper; and

the pressing block assembly is located in the shell assembly, and the tray assembly can extend out of the shell assembly.

2. The biochemical analyzer according to claim 1, wherein the biochemical analyzer comprises a control unit, the actuating mechanism comprises an electromagnet, a first bracket and a second bracket, the control unit is configured to control switching between an energized state and a de-energized state of the electromagnet, the electromagnet is capable of generating an ascending motion in the energized state, the electromagnet and the pressing block body are both fixedly connected to the first bracket, and the second bracket is fixedly connected to the housing assembly.

3. The biochemical analyzer according to claim 2, wherein the actuating mechanism further comprises a guide shaft and a linear bearing, the guide shaft passes through the linear bearing, the linear bearing is fixedly connected with the second bracket, and the guide shaft is fixedly connected with the first bracket.

4. The biochemical analyzer of claim 3, wherein the actuating mechanism further comprises a compression spring, the compression spring being sleeved on the guide shaft.

5. The biochemical analyzer according to claim 2, wherein the electromagnet is fixedly connected to the first bracket via an electromagnet connecting member, and the electromagnet connecting member comprises a plastic material.

6. The biochemical analyzer according to claim 1, further comprising an in-out compartment assembly, wherein the in-out compartment assembly comprises a third bracket, a motor, a tray adapter element and a guide rail, the tray adapter element is fixedly connected to the tray body, the motor and the guide rail are both mounted on the third bracket, an output end of the motor is in transmission connection with the tray adapter element through a screw-nut pair, and the tray connecting element can move along the guide rail.

7. The biochemical analyzer of claim 6, wherein the access compartment assembly further comprises a position detection element for detecting a movement position of the tray adapter element.

8. The biochemical analyzer according to claim 7, wherein the position detecting element includes a first position detecting element and a second position detecting element, the first position detecting element and the second position detecting element are both mounted on the third bracket, and the first position detecting element is configured to detect a moving position of the tray switching element when the screw of the screw-nut pair is rotated forward, and the second position detecting element is configured to detect a moving position of the tray switching element when the screw of the screw-nut pair is rotated backward.

9. The biochemical analyzer according to claim 8, wherein the first position detecting element and the second position detecting element are both optical couplers, and the tray connecting element is further provided with an optical coupler blocking sheet.

10. The biochemical analyzer according to any one of claims 1 to 9, further comprising an optical path component comprising a first LED lamp component having a wavelength of 405nm, a second LED lamp component having a wavelength of 550nm, and a third LED lamp component having a wavelength of 610 nm.

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