CN212476692U - Chimeric antigen receptor T cell preparation device for treating AML - Google Patents

Abstract

The utility model discloses an gomphosis antigen receptor T cell preparation facilities for treating AML, including main part, time-recorder, ultraviolet ray disinfection lamp and feed inlet, the right-hand member of main part is provided with puts the thing cabinet, and puts the bottom arrangement of thing cabinet and have the separating chamber, the outer wall of separating chamber is fixed with temperature controller, and the inboard bottom of separating chamber is provided with first thing board of putting, the first inside culture dish that is provided with in top left side of putting the thing board, and the outer wall of culture dish installs the microscope lens, the time-recorder is fixed in the first right side bottom of putting the thing board, the inboard left end of putting the thing cabinet is provided with the draw-in groove, and the right-hand member of draw-in groove is provided with the slider, the ultraviolet ray disinfection lamp is installed in the inboard top middle part of putting the thing cabinet, the second is installed. The chimeric antigen receptor T cell preparation device for treating AML regulates and controls the temperature according to different stages of separating T cells through the action of the temperature controller, so that the T cells can be better separated.

Description

Chimeric antigen receptor T cell preparation device for treating AML

Technical Field

The utility model relates to a cell preparation technical field specifically is a gomphosis antigen receptor T cell preparation facilities for treating AML.

Background

Chimeric antigen receptor T cells (CAR-T) are a newly developed cell therapy technology for treating tumors, and the therapy mode has high specificity and good effect and is valued by the medical field. The antigen binding portion of an antibody that CAR-T recognizes a certain tumor antigen is coupled in vitro to an immunoreceptor tyrosine activation motif, usually the intracellular portion, as a chimeric protein, and T cells of a patient are transfected by gene transduction to express a Chimeric Antigen Receptor (CAR), thereby helping the patient treat AML disease.

The existing antigen receptor cell preparation device is simple and can be observed by foreign objects in the preparation process, and therefore, a chimeric antigen receptor T cell preparation device for treating AML is provided.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a chimeric antigen receptor T cell preparation facilities for treating AML to the antigen receptor cell preparation facilities who proposes in solving above-mentioned background art is fairly simple, must carry out the problem of observing with the help of the foreign object in the preparation process.

In order to achieve the above object, the utility model provides a following technical scheme: a chimeric antigen receptor T cell preparation device for treating AML comprises a main body, a timer, an ultraviolet disinfection lamp and a feed inlet, wherein a storage cabinet is arranged at the right end of the main body, a separation chamber is arranged at the bottom end of the storage cabinet, a temperature controller is fixed on the outer wall of the separation chamber, a first storage plate is arranged at the bottom end of the inner side of the separation chamber, a culture dish is arranged inside the left side of the top end of the first storage plate, a microscope lens is arranged on the outer wall of the culture dish, the timer is fixed at the bottom end of the right side of the first storage plate, a clamping groove is arranged at the left end of the inner side of the storage cabinet, a sliding block is arranged at the right end of the clamping groove, the ultraviolet disinfection lamp is arranged in the middle of the top end of the inner side of the storage cabinet, a second storage plate is arranged at the right end of the sliding block, a test tube is arranged, the feed inlet sets up in the top of culture dish, the top of feed inlet is provided with the protective cover.

Preferably, the storage cabinet is rectangular, the interior of the storage cabinet is hollow, and the test tubes are distributed equidistantly.

Preferably, the temperature controller is fixedly connected with the separation chamber, and the first object placing plate is movably connected with the culture dish.

Preferably, be fixed connection between timer and the first thing board of putting, be welding integrated structure between draw-in groove and the main part simultaneously.

Preferably, the ultraviolet disinfection lamp and the storage cabinet are welded, and the labels are equidistantly distributed.

Preferably, the feed inlet is circular, and is swing joint between feed inlet and the protective cover.

Compared with the prior art, the beneficial effects of the utility model are that:

1. this a setting that is used for chimeric antigen receptor T cell preparation facilities of treatment AML puts thing cabinet is the blood of patient collection in order to save the test tube, conveniently utilize the blood in the test tube to extract the T cell, conveniently carry out the preparation of T cell, temperature controller's effect is according to the regulation and control that the different stages of separation T cell carried out the temperature, make the T cell can be better separate, first setting of putting the thing board is used for placing the culture dish, make things convenient for it to carry out cultivation on next step, the culture dish is used for separating and activation T cell, the microscope slide is the step of preparing in order to avoid increasing, thereby the efficiency of preparation has been improved, the number after the T cell activation is observed to the microscope slide simultaneously.

2. The timer of the chimeric antigen receptor T cell preparation device for treating AML is arranged so that the time of each stage can be mastered when T cells are separated conveniently, the separation process is more accurate, the ultraviolet disinfection lamp is arranged so that the main body can be disinfected by the ultraviolet disinfection lamp before each use or after the use is finished, the phenomenon of cross infection is avoided when the next use is carried out, and the label is used for conveniently and respectively collecting blood samples of patients and avoiding the phenomenon of errors.

3. This a chimeric antigen receptor T cell preparation facilities feed inlet for treating AML sets up in order to be after T cell separation and activation end, to its inside addition CAR, make it infect CAR and reinfuse back to the patient in vivo through quality control, treat patient, the protective cover is in order when the feed inlet need not use, make it form an inclosed space, thereby effectively prevent that the culture dish from receiving the infection of foreign object, when the protective cover that needs to use, just can make the culture dish form an inclosed space when utilizing the pivot of its bottom to rotate it to the position of laminating with the feed inlet.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a schematic view of the internal structure of the storage cabinet of the present invention;

fig. 3 is a schematic view of the top view structure of the culture dish of the present invention.

In the figure: 1. a main body; 2. a storage cabinet; 3. a separation chamber; 4. a temperature controller; 5. a micro-lens; 6. a first object placing plate; 7. a culture dish; 8. a timer; 9. a card slot; 10. a slider; 11. an ultraviolet disinfection lamp; 12. labeling; 13. a second storage plate; 14. a test tube; 15. a protective cover; 16. and (4) feeding a material inlet.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-3, the present invention provides a technical solution: a chimeric antigen receptor T cell preparation device for treating AML comprises a main body 1, a storage cabinet 2, a separation chamber 3, a temperature controller 4, a microscope lens 5, a first storage plate 6, a culture dish 7, a timer 8, a clamping groove 9, a sliding block 10, an ultraviolet disinfection lamp 11, a label sticker 12, a second storage plate 13, a test tube 14, a protective cover 15 and a feed inlet 16, wherein the storage cabinet 2 is arranged at the right end of the main body 1, the separation chamber 3 is arranged at the bottom end of the storage cabinet 2, the temperature controller 4 is fixed on the outer wall of the separation chamber 3, the first storage plate 6 is arranged at the bottom end of the inner side of the separation chamber 3, the culture dish 7 is arranged inside the left side of the top end of the first storage plate 6, the microscope lens 5 is arranged on the outer wall of the culture dish 7, the timer 8 is fixed at the bottom end of the right side of the first storage plate 6, the clamping groove 9 is arranged at the left end of the inner side of the storage cabinet, the ultraviolet disinfection lamp 11 is arranged in the middle of the top end of the inner side of the storage cabinet 2, the right end of the sliding block 10 is provided with a second storage plate 13, a test tube 14 is arranged inside the right side of the top end of the second storage plate 13, a label sticker 12 is fixed on the outer wall of the test tube 14, a feed port 16 is arranged at the top end of the culture dish 7, and a protective cover 15 is arranged at the top end of the feed port 16;

the storage cabinet 2 is rectangular, the interior of the storage cabinet 2 is hollow, the test tubes 14 are distributed at equal intervals, and the storage cabinet 2 is arranged for storing blood collected by a patient in the test tubes 14, so that T cells can be conveniently extracted by using the blood in the test tubes 14, and the preparation of the T cells is convenient;

the temperature controller 4 is fixedly connected with the separation chamber 3, the first object placing plate 6 is movably connected with the culture dish 7, the temperature controller 4 is used for regulating and controlling the temperature according to different stages of T cell separation, so that the T cells can be better separated, the culture dish 7 is placed on the first object placing plate 6 to facilitate the next cultivation of the T cells, the culture dish 7 is used for separating and activating the T cells, the microscope slide 5 is used for avoiding increasing the preparation steps, the preparation efficiency is improved, and the number of the activated T cells is observed by the microscope slide 5;

the timer 8 is fixedly connected with the first object placing plate 6, meanwhile, the clamping groove 9 and the main body 1 are of a welding integrated structure, and the timer 8 is arranged so that the time of each stage can be mastered when T cells are separated, so that the separation process is more accurate;

the ultraviolet disinfection lamp 11 and the storage cabinet 2 are welded, meanwhile, the label stickers 12 are distributed at equal intervals, the ultraviolet disinfection lamp 11 is arranged to disinfect the main body 1 before each use or after the use is finished, the phenomenon of cross infection in the next use is avoided, and the label stickers 12 are used for facilitating blood samples of patients respectively and avoiding the phenomenon of errors;

the feed inlet 16 is round, the feed inlet 16 is movably connected with the protective cover 15, the feed inlet 16 is arranged to add CAR into the feed inlet 16 after T cells are separated and activated, the CAR is infected and then is returned to a patient through quality control, and the patient is treated, the protective cover 15 is arranged to form a closed space when the feed inlet 16 is not needed, so that the culture dish 7 is effectively prevented from being infected by foreign objects, and when the protective cover 15 is needed, the culture dish 7 can form a closed space when the rotary shaft at the bottom end of the protective cover rotates to a position attached to the feed inlet 16.

The working principle is as follows: for the chimeric antigen receptor T cell preparation device for treating AML, firstly, the arrangement of the storage cabinet 2 is to store blood collected by a patient in the test tube 14, the T cells are conveniently extracted by using the blood in the test tube 14, so as to prepare the T cells, the temperature controller 4 is used for regulating and controlling according to the temperature required by different stages when the T cells are separated, so that the T cells can be better separated, the first storage plate 6 is arranged for placing the culture dish 7, so as to be convenient for the next cultivation, the movable design between the clamping groove 9 and the sliding block 10 is used for conveniently pulling the first storage plate 6, when the first storage plate 6 is pulled out from the interior of the storage cabinet 2, the handle at the bottom end is held, the first storage plate can be pulled out of the interior of the storage cabinet 2 by utilizing the direct activity of the clamping groove 9 and the sliding block 10, the culture dish 7 is used for separating and activating the T cells, the micro lens 5 is to avoid increasing the preparation step and thus improving the preparation efficiency, when the micro lens 5 is needed to be used, the number of activated T cells can be observed through the micro lens, so as to carry out the next step, the timer 8 is arranged to facilitate the time of each stage to be mastered when the T cells are separated, so that the separation process is more accurate, the ultraviolet disinfection lamp 11 is arranged to utilize the ultraviolet disinfection lamp to disinfect the main body 1 before each use or after the use is finished, so as to avoid the phenomenon of cross infection when the T cells are used next time, the label sticker 12 is arranged to facilitate the blood samples of patients respectively and avoid the phenomenon of error, the feed inlet 16 is arranged to add CAR after the T cells are separated and activated, so that the CAR is infected and then is infused into the bodies of the patients through quality control, treat patient, protective cover 15 is in order when feed inlet 16 need not use for it forms a confined space, thereby effectively prevent that culture dish 7 from receiving the infection of foreign object, when protective cover 15 need use, utilize the pivot of its bottom with its rotatory position with feed inlet 16 laminating in the time just can make culture dish 7 form a confined space, the setting of second thing board 13 is for better placing culture dish 7, make things convenient for it to observe the state of T cell in the culture dish 7 at any time.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (6)

1. A chimeric antigen receptor T cell preparation device for treating AML comprising a main body (1), a timer (8), an ultraviolet ray disinfection lamp (11) and a feed inlet (16), characterized in that: the test tube box is characterized in that a storage cabinet (2) is arranged at the right end of the main body (1), a separation chamber (3) is arranged at the bottom end of the storage cabinet (2), a temperature controller (4) is fixed on the outer wall of the separation chamber (3), a first storage plate (6) is arranged at the bottom end of the inner side of the separation chamber (3), a culture dish (7) is arranged inside the left end of the top end of the first storage plate (6), a microscope lens (5) is arranged on the outer wall of the culture dish (7), a timer (8) is fixed at the bottom end of the right side of the first storage plate (6), a clamping groove (9) is arranged at the left end of the inner side of the storage cabinet (2), a sliding block (10) is arranged at the right end of the clamping groove (9), an ultraviolet disinfection lamp (11) is arranged in the middle of the top end of the inner side of the storage cabinet (2), a second storage plate (13) is arranged on the sliding block (10), and a test, the outer wall of test tube (14) is fixed with label subsides (12), feed inlet (16) set up in the top of culture dish (7), the top of feed inlet (16) is provided with protective cover (15).

2. The apparatus for preparing chimeric antigen receptor T cells for AML according to claim 1, wherein: put thing cabinet (2) and be the rectangle form, and put the inside of thing cabinet (2) and be the cavity form, be the equidistance distribution between test tube (14) simultaneously.

3. The apparatus for preparing chimeric antigen receptor T cells for AML according to claim 1, wherein: the temperature controller (4) is fixedly connected with the separating chamber (3), and the first object placing plate (6) is movably connected with the culture dish (7).

4. The apparatus for preparing chimeric antigen receptor T cells for AML according to claim 1, wherein: timer (8) and first putting are fixed connection between thing board (6), are welding integrated structure between draw-in groove (9) and main part (1) simultaneously.

5. The apparatus for preparing chimeric antigen receptor T cells for AML according to claim 1, wherein: the ultraviolet disinfection lamp (11) and the storage cabinet (2) are welded, and meanwhile, the label stickers (12) are distributed at equal intervals.

6. The apparatus for preparing chimeric antigen receptor T cells for AML according to claim 1, wherein: the feed inlet (16) is round, and the feed inlet (16) is movably connected with the protective cover (15).

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