CN206587807U - A kind of special liquor folliculi test tube thermostat of operating room - Google Patents

A kind of special liquor folliculi test tube thermostat of operating room Download PDF

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Publication number
CN206587807U
CN206587807U CN201720180967.1U CN201720180967U CN206587807U CN 206587807 U CN206587807 U CN 206587807U CN 201720180967 U CN201720180967 U CN 201720180967U CN 206587807 U CN206587807 U CN 206587807U
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China
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test tube
muff
support
thermostat
heat preservation
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Expired - Fee Related
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CN201720180967.1U
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Chinese (zh)
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谢金芳
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Individual
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Individual
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Abstract

The utility model is related to a kind of special liquor folliculi test tube thermostat of operating room, including test tube and constant temperature test tube support and muff, the muff is tubulose, lower end closed, upper end open formation accommodates the heat insulation cavity of test tube, and the inwall of the lower end of muff is provided with heat-insulation layer, heat-insulation layer provided with carbon fiber heating silk, the outer wall of the muff is provided with battery and temperature switch, and temperature switch is connected by electric wire with battery and carbon fiber heating silk;The side wall of the muff is provided with two otch from upper end Longitudinal extending downwards, and the tube wall formation adjustment sheet between two otch, the inwall of adjustment sheet is provided with the clamp protruded to muff central axis.Test tube thermostat of the present utility model, test tube can be separated from thermostat as needed, make in the isoperibol that ovum maintains 37 degree all the time, the test tube of taking-up can carry out directly observing and operating to test tube, it enormously simplify the operation sequence of ova harvest, procedure efficiency is improved, fertilization and pregnancy rate is improved.

Description

A kind of special liquor folliculi test tube thermostat of operating room
Technical field
The utility model is related to technical field of medical instruments, specifically, is that a kind of special liquor folliculi test tube of operating room is permanent Warm device.
Background technology
Estimate according to the World Health Organization, the 10-15% couple at child-bearing age is perplexed by infertility in developed country.Developing country In, the women of child-bearing age to 2002 young 1.86 hundred million suffer from infertility.The statistics of 2014 shows, China's reproductive population infertility Incidence be 12.5%, infertility number be more than 40,000,000.IVF-ET Technique is current treatment infertility Important means.From 1978 since the first " test-tube baby " in the world is born in Britain, current developed country passes through in vitro fertilization Help the baby of pregnant birth to account for the 1-3% of natus sum, estimate the births of whole world test-tube baby more than 500 Ten thousand people., it is necessary in vitro to mankind's gamete (sperm and egg mother cell) during fertilization-embryo transfer technology is implemented in vitro And embryo carries out various observations and operation.Suitable temperature is the essential condition for maintaining gamete and embryo's normal existence, once The temperature of environment changes, and its various normal physiological activity will be influenced to different extents.Optimum mankind gamete and The temperature of embryo cutting is 37 DEG C, difficult during they leave human body or incubator carries out observation in vitro and operation Occurs the fluctuation of temperature with the meeting avoided.Mankind's gamete and embryo are very sensitive, of short duration temperature for the fluctuation of temperature Decline (5-10 minutes), the depolymerization of spindle microtubule albumen may be caused, so as to cause meiosis or the embryo of egg mother cell Mitosis during aneuploid or chimera generation.In addition, temperature drop can also influence the activity ratio of sperm, cause Its fertility declines.The temperature drop (> 1 hour) of long period, it will change gamete and the metabolic process of embryo, increase Chromosome abnormality odds, and reduce its potential for continuing to develop.Therefore trained in vitro to mankind's gamete and embryo In foster process, if at utmost maintaining the stability of vitro, influence of the external environment fluctuation to embryonic development is reduced, It is the major issue that each current laboratory in vitro fertilization must take into consideration.
In vitro in fertilization laboratory, doctor imports the liquor folliculi of patient by suction tube in the test tube of constant temp test tube rack It is interior.The special liquor folliculi test tube thermostat of operating room is there is no at present, it is general in ova harvest to use laboratory test tube constant temperature Frame holding test tubes simultaneously carry out heated at constant temperature to test tube, and this constant temp test tube rack is fixed, because the length of suction tube has Limit is in operating process and its inconvenient, it is necessary to the larger rack for test tube of volume is moved into operation table, and the test tube in rack for test tube It can not be taken out from thermostatic frame, medical personnel are also difficult to the inflow velocity and influx that observation flows into invisible spectro liquor folliculi, nothing Method judges whether Endo-esophageal liquid is filled.Prior art also discloses that a variety of liquor folliculi constant temperature oesophagus devices, such as Chinese patent 201420054044.8 disclose a kind of ova harvest liquor folliculi oesophagus thermostat, including the constant temperature with heat conductivility adds The support 2 that hot body 1 and upper end are connected with the rear wall of heated at constant temperature body 1, the front side of the heated at constant temperature body 1 is offered side by side At least two deep-slotted chip breakers 3, the upper end open of deep-slotted chip breaker 3, lower end closed, and have and liquor folliculi test tube outside wall surface shape phase The inwall of adaptation, its blind end is test tube base 4, and the bottom surface of heated at constant temperature body 1 and the bottom surface of support 2 are in same plane, arc It is in the angle of 40-50 degree between the axis of shape groove 3 and the plane, what the oesophagus thermostat was solved is that test tube takes out operation and seen The problem of examining simple operation, test tube still can not leave rack for test tube.Chinese patent 201521128498.6 discloses a kind of test tube Vertically arranged groove is provided with attemperator, including vertically arranged riser and light-passing board, the side wall of the riser, it is described Vertically arranged groove is provided with the side wall of tabula rasa, the identical docking formation of the groove on groove and light-passing board on the riser is used for The heat preservation channel of oesophagus is placed, the top of heat preservation channel is opening, and what the attemperator was solved is that heating plate directly heats efficiency Lowly, and conventional vacuum device can not carry out the shortcoming that carries out directly observing and operating to test tube, test tube still can not leave Attemperator.Therefore in view of the shortcomings of the prior art, it is necessary to design a kind of special liquor folliculi test tube thermostat of operating room, energy Test tube is separated from thermostat, in the case where not influenceing the survival rate of ovum, is easy to that test tube is carried out directly to observe and grasp Make, and report is yet there are no on such device.
The content of the invention
The purpose of this utility model is to provide a kind of special liquor folliculi test tube thermostat of operating room.
To achieve the above object, the utility model is adopted the technical scheme that:
A kind of special liquor folliculi test tube thermostat of operating room, including test tube (1) and constant temperature test tube support (2), the perseverance Warm test tube support (2) is made up of fixed support (3), left socle (4) and right support (5), and the fixed support (3) is by firm banking (6) and test tube support (7) composition, the firm banking (6) is fixedly connected with test tube support (7), test tube support (7) and left socle (4) detachable connection and between right support (5);It is vertically arranged at least provided with one on the side of the test tube support (7) There are a semicircular cavities (8), at least provided with a vertically arranged semicircle on the medial surface of the left socle (4) and right support (5) Shape cavity (8), after test tube support (7) is connected with left socle (4) or right support (5), the semicircle on the test tube support (7) Shape cavity (8) forms at least one with the semicircular cavities (8) on left socle (4) or the semicircular cavities (8) on right support (5) For the heat preservation channel (9) of holding test tubes (1), the top of the heat preservation channel (9) is opening;The firm banking (6) is provided with temperature Display screen (15), outlet (16) and temperature controller are spent, the temperature display (15), outlet (16) are arranged on solid Determine the side of base (6);Lateral surface on the left socle (4) or right support (5) is provided with information flag plate (17), described information The quantity of marking plate (17) is identical with the quantity of heat preservation channel (9);
The test tube thermostat also includes muff (10), and the muff (10) is tubulose, and lower end closed, upper end is opened Mouth forms the heat insulation cavity (11) for accommodating test tube (1), the outer wall and the inwall phase of heat preservation channel (9) of the muff (10) Match somebody with somebody, the outer wall of the inwall and test tube (1) of the muff (10) matches, test tube (1) can be inserted into muff (10) in and together with Muff (10) is inserted in heat preservation channel (9) together;The inwall of the lower end of the muff (10) is provided with heat-insulation layer, the guarantor Provided with carbon fiber heating silk in warm layer, the outer wall of the muff (10) is provided with battery (12) and temperature switch (13), temperature Switch (13) is connected by electric wire with battery (12) and carbon fiber heating silk;The side wall of the muff (10) provided with two from Tube wall formation adjustment sheet (18) between the otch (14) of upper end Longitudinal extending downwards, two otch (14), the adjustment sheet (18) inwall is provided with the clamp (19) protruded to muff (10) central axis.
Further, the heat-insulation layer is by graphite material, alumina fibre, titanium alloy, stainless steel, ceramic material or alumina silicate Cellucotton is made
Further, the heat preservation channel (9) is provided with 2 rows, and the heat preservation channel (9) arranges provided with 3-10.
Further, the detachable connection is mode connects for screw, bolt connection or flange connection.
Further, the clamp (19) is made up of elastic polyurethane.
Further, the length of the test tube is 9-12cm;Preferably, the length of the test tube be 9cm, 10cm, 11cm or 12cm。
Further, the internal diameter of the test tube is 1-1.5cm;Preferably, the internal diameter of the test tube 1 be 1.2cm, 1.3cm or 1.5cm。
Further, the profile of the constant temperature test tube support is rectangle, and its a length of 30-50cm, a width of 15-30cm are a height of 20-40cm, it is preferred that its a length of 30cm, 35cm, 40cm, 45cm, a width of 15cm, 20cm, 25cm, 30cm, a height of 20cm, 25cm、30cm、40cm。
The utility model advantage is:
1st, test tube thermostat of the present utility model, test tube can be separated, make ovum from thermostat as needed Son is maintained in 37 degree of isoperibol all the time, and the test tube of taking-up can carry out directly observing and operating to test tube, enormously simplify The operation sequence of ova harvest, improves procedure efficiency, improves fertilization and pregnancy rate.
2nd, test tube thermostat of the present utility model, the constant temperature test tube support is by fixed support, left socle and right support 5 Composition, left socle 4 and right support 5 can be disassembled and heat preservation channel cleaned, with unitary design ratio when not in use Relatively cleaning more facilitates, and is conducive to removing the laying dust in heat preservation channel so that test tube thermostat has good heat insulation function, Either component is damaged simultaneously, and need to only change damage part just can normally use, and reduce maintenance cost.
3rd, the lateral surface on test tube thermostat of the present utility model, the left socle or right support is provided with information flag Plate, the quantity of described information marking plate is identical with the quantity of heat preservation channel, one test tube of each information flag plate correspondence, the design Facilitate medical personnel that each test tube is marked in surgical procedure, prevent different invisible spectro ovum quilts in post-processing Obscure, it is to avoid cause malpractice.
Brief description of the drawings
Accompanying drawing 1 is the structural representation of the special liquor folliculi test tube thermostat of the utility model operating room.
Accompanying drawing 2 is the fractionation schematic diagram of the special liquor folliculi test tube thermostat of the utility model operating room.
Accompanying drawing 3 is the structural representation of constant temperature test tube support in the utility model.
Accompanying drawing 4 is the structural representation of liquor folliculi test tube in the utility model.
Accompanying drawing 5 is the front schematic view of muff in the utility model.
Accompanying drawing 6 is the schematic rear view of muff in the utility model.
Accompanying drawing 7 is the structural representation of muff in the utility model.
Embodiment
With reference to embodiment, the utility model is expanded on further.It should be understood that these embodiments are merely to illustrate The utility model rather than limitation scope of the present utility model.In addition, it is to be understood that reading in the utility model record After appearance, those skilled in the art can make various changes or modifications to the utility model, and these equivalent form of values equally fall within this Apply for appended claims limited range.
The reference and part being related in accompanying drawing are as follows:
1. the fixed support of 2. constant temperature test tube support of test tube 3.
4. the firm banking of 5. right support of left socle 6.
7. the heat preservation channel of 8. semicircular cavities of test tube support 9.
10. the battery of 11. heat insulation cavity of muff 12.
13. the temperature display of 14. otch of temperature switch 15.
16. the adjustment sheet of 17. information flag plate of outlet 18.
19. clamp
The special liquor folliculi test tube thermostat of the utility model operating room of embodiment 1
Refer to Fig. 1-Fig. 6.Accompanying drawing 1 is that the utility model takes the structure of the special liquor folliculi test tube thermostat of operating room to show It is intended to, accompanying drawing 2 is the fractionation schematic diagram of the special liquor folliculi test tube thermostat of the utility model operating room, accompanying drawing 3 is this practicality The structural representation of new middle constant temperature test tube support, accompanying drawing 4 is the structural representation of liquor folliculi test tube in the utility model, accompanying drawing 5 be the front schematic view of muff in the utility model, and accompanying drawing 6 is the schematic rear view of muff in the utility model, accompanying drawing 7 be the structural representation of muff in the utility model,
A kind of special liquor folliculi test tube thermostat of operating room, including test tube 1 and constant temperature test tube support 2, the test tube 1 by Test tube body and cap test tube composition, test tube body are used for loading liquid, and cap test tube passes through the detachable company of screw thread with test tube body Connect.The constant temperature test tube support 2 is made up of fixed support 3, left socle 4 and right support 5, and the fixed support 3 is by firm banking 6 and test tube support 7 constitute, the firm banking 6 is fixedly connected with test tube support 7, test tube support 7 and left socle 4 and right support 5 Between detachable connection, the detachable connection be mode connects for screw, bolt connection or flange connection;The test tube support 7 Side at least provided with one it is vertically arranged have semicircular cavities 8, the medial surface of the left socle 4 and right support 5 is up to Less provided with a vertically arranged semicircular cavities 8, after test tube support 7 is connected with left socle 4 or right support 5, the test tube Semicircular cavities 8 on support 7 are formed at least with the semicircular cavities 8 on left socle 4 or the semicircular cavities 8 on right support 5 One is used for the heat preservation channel 9 of holding test tubes 1, and the top of the heat preservation channel 9 is opening;The firm banking 6 is aobvious provided with temperature Display screen 15, outlet 16 and temperature controller, the temperature display 15, outlet 16 are arranged on the side of firm banking 6 Face;Lateral surface on the left socle 4 or right support 5 is provided with information flag plate 17, the quantity of described information marking plate 11 and guarantor The quantity of warm passage 9 is identical.
The test tube thermostat also includes muff 10, and the muff 10 is tubulose, lower end closed, upper end open shape Into the heat insulation cavity 11 for accommodating test tube 1, the outer wall and the inwall of heat preservation channel 9 of the muff 10 match, the muff The outer wall of 10 inwall and test tube 1 matches, and test tube 1, which can be inserted into muff 10 and insert insulation together with muff 10, to be led to In road 9;The inwall of the lower end of the muff 10 is provided with heat-insulation layer, and the heat-insulation layer is by graphite material, alumina fibre, titanium Alloy, stainless steel, ceramic material or aluminosilicate fiber cotton are made, provided with carbon fiber heating silk, the muff 10 in heat-insulation layer Outer wall be provided with battery 12 and temperature switch 13, temperature switch 13 is connected by electric wire and battery 12 and carbon fiber heating thread; The side wall of the muff 10 is provided with two otch 14 from upper end Longitudinal extending downwards, the tube wall between two otch 14 Adjustment sheet 18 is formed, the inwall of the adjustment sheet 18 is provided with the clamp 19 protruded to the central axis of muff 10, the clamp 19 It is made up of elastic polyurethane.
In one embodiment of the present utility model, the heat preservation channel 9 is provided with 2 rows, and the heat preservation channel 9 is provided with 3-10 Row.
In one embodiment of the present utility model, the length of the test tube 1 is 9-12cm;Preferably, the test tube 1 Length is 9cm, 10cm, 11cm or 12cm.
In one embodiment of the present utility model, the internal diameter of the test tube 1 is 1-1.5cm;Preferably, the test tube 1 Internal diameter be 1.2cm, 1.3cm, 1.4cm or 1.5cm.
In one embodiment of the present utility model, the profile of the constant temperature test tube support 2 is rectangle, its a length of 30- 50cm, a width of 15-30cm, a height of 20-40cm, it is preferred that its a length of 30cm, 35cm, 40cm, 45cm, a width of 15cm, 20cm, 25cm, 30cm, a height of 20cm, 25cm, 30cm, 40cm.
It should be noted that in the utility model, the constant temperature test tube support 2 is by fixed support 3, left socle 4 and right branch Frame 5 is constituted, and the fixed support 3 is made up of firm banking 6 and test tube support 7, test tube support 7 and left socle 4 and right support 5 Between detachable connection, the design make it that constant temperature test tube support, when not in use can be by left socle 4 and right branch to be dismountable Frame 5 is disassembled to be cleaned to heat preservation channel, and cleaning is compared with unitary design and is more facilitated, and is conducive to removing heat preservation channel Interior laying dust so that test tube thermostat has good heat insulation function;While the firm banking 6 and test tube support of different device Between 7 can Optional assembling, even if either component damage, only need to change damage part just can normally use, reduce maintenance cost, this The outer connected mode by screw, by the solid degree of the anxiety for changing screw, can change the size of heat preservation channel, so as to for Fixed different size of test tube and muff, applicability are stronger.
In the utility model, the firm banking 6 is provided with temperature display 15, outlet 16 and temperature controller, institute State temperature display 15, outlet 16 and be arranged on the side of firm banking 6, after outlet 16 connects power supply, temperature control Device processed control is arranged on the heating-up temperature of the heating tube in firm banking 6, can by the temperature control in heat preservation channel 9 at 37 degree, The temperature is identical with human body temperature, can make to be placed in the isoperibol that invisible spectro ovum remains at 37 degree, be conducive to The survival of ovum, improves success rate in vitro fertilization.
In the utility model, the lateral surface on the left socle 4 or right support 5 is provided with information flag plate 17, described information The quantity of marking plate 11 is identical with the quantity of heat preservation channel 9, and one test tube of each information flag plate correspondence, the design facilitates medical care Each test tube is marked in surgical procedure by personnel, prevents different invisible spectro ovums to be confused in post-processing, keeps away Exempt to cause malpractice.
In the utility model, the test tube thermostat also includes muff 10, the inwall of the lower end of the muff 10 It is provided with heat-insulation layer, heat-insulation layer provided with carbon fiber heating silk, the outer wall of the muff 10 is opened provided with battery 12 and temperature 13 are closed, temperature switch 13 is connected by electric wire with battery 12 and carbon fiber heating silk.Temperature open pipe 13 is opened, carbon fiber adds Temperature is raised after heated filament is powered, and heat-insulation layer is maintained 37 degree all the time, the test tube 1 being so placed in muff 10 can be filled from constant temperature Middle taking-up is put, the test tube for leaving attemperator is maintained 37 degree for a long time.The design " can solve test tube from thermostat Put " come out, medical personnel as needed can together take out test tube together with muff during ova harvest, test tube be carried out straight Connect observation and operate, greatly facilitate the ova harvest operation of medical personnel, simplify surgical procedure, improve procedure efficiency.
In the utility model, the side wall of the muff 10 provided with two otch 14 from upper end Longitudinal extending downwards, Tube wall formation adjustment sheet 18 between two otch 14, the inwall of the adjustment sheet 18, which is provided with to the central axis of muff 10, to be protruded Clamp 19, the clamp 19 and be made up of flexible polyurethane material, the design can make the test tube inserted in muff Fixation is more firm, while can avoid causing the deformation of test tube due to the excessive chucking power of test tube generation after being used for a long time, will Test tube is placed on muff and the operation of taking-up test tube is more convenient.
Advantage of the present utility model:
(1) test tube thermostat of the present utility model, test tube can be separated, make ovum from thermostat as needed Son is maintained in 37 degree of isoperibol all the time, and the test tube of taking-up can carry out directly observing and operating to test tube, enormously simplify The operation sequence of ova harvest, improves procedure efficiency, improves fertilization and pregnancy rate.
(2) test tube thermostat of the present utility model, the constant temperature test tube support is by fixed support, left socle and right support 5 compositions, left socle 4 and right support 5 can be disassembled and heat preservation channel cleaned, with unitary design when not in use Compare cleaning more to facilitate, be conducive to removing the laying dust in heat preservation channel so that test tube thermostat has good insulation work( Can, while either component is damaged, need to only change damage part just can normally use, and reduce maintenance cost.
(3) lateral surface on test tube thermostat of the present utility model, the left socle or right support is provided with information flag Plate, the quantity of described information marking plate is identical with the quantity of heat preservation channel, one test tube of each information flag plate correspondence, the design Facilitate medical personnel that each test tube is marked in surgical procedure, prevent different invisible spectro ovum quilts in post-processing Obscure, it is to avoid cause malpractice.

Claims (4)

1. a kind of special liquor folliculi test tube thermostat of operating room, including test tube (1) and constant temperature test tube support (2), its feature exist In the length of the test tube (1) is 12cm, and the internal diameter of the test tube (1) is 1.5cm, the profile of the constant temperature test tube support (2) For rectangle, a length of 45cm, a width of 30cm, a height of 40cm;The constant temperature test tube support (2) is by fixed support (3), left socle (4) and right support (5) composition, the fixed support (3) is made up of firm banking (6) and test tube support (7), the firm banking (6) it is fixedly connected with test tube support (7), detachable connection between test tube support (7) and left socle (4) and right support (5);Institute State semicircular cavities (8) vertically arranged at least provided with one on the side of test tube support (7), the left socle (4) and right branch At least provided with a vertically arranged semicircular cavities (8) on the medial surface of frame (5), when test tube support (7) and left socle (4) or After right support (5) connection, the semicircular cavities (8) on the test tube support (7) and the semicircular cavities (8) on left socle (4) Or the semicircular cavities (8) on right support (5) form at least one heat preservation channel (9) for holding test tubes (1), the insulation is led to The top in road (9) is opening;The firm banking (6) is provided with temperature display (15), outlet (16) and temperature controller, The temperature display (15), outlet (16) are arranged on the side of firm banking (6);The left socle (4) or right support (5) lateral surface on is provided with information flag plate (17), the quantity phase of the quantity and heat preservation channel (9) of described information marking plate (17) Together;The test tube thermostat also includes muff (10), and the muff (10) is tubulose, lower end closed, upper end open shape Into the heat insulation cavity (11) for accommodating test tube (1), the outer wall and the inwall of heat preservation channel (9) of the muff (10) match, institute The outer wall for stating the inwall and test tube (1) of muff (10) matches, and test tube (1) can be inserted into muff (10) and together with muff (10) insert together in heat preservation channel (9);The inwall of the lower end of the muff (10) is provided with heat-insulation layer, the heat-insulation layer and set There is carbon fiber heating silk, the outer wall of the muff (10) is provided with battery (12) and temperature switch (13), temperature switch (13) It is connected by electric wire with battery (12) and carbon fiber heating silk;The side wall of the muff (10) provided with two from upper end downwards Tube wall formation adjustment sheet (18) between the otch (14) of Longitudinal extending, two otch (14), the inwall of the adjustment sheet (18) Provided with the clamp (19) protruded to muff (10) central axis.
2. the special liquor folliculi test tube thermostat of operating room according to claim 1, it is characterised in that the heat preservation channel (9) 2 rows are provided with, the heat preservation channel (9) arranges provided with 3-10.
3. the special liquor folliculi test tube thermostat of operating room according to claim 1, it is characterised in that the detachable company It is connected in mode connects for screw, bolt connection or flange connection.
4. the special liquor folliculi test tube thermostat of operating room according to claim 1, it is characterised in that the clamp (19) sets Put in the position close to muff (10) upper end.
CN201720180967.1U 2017-02-28 2017-02-28 A kind of special liquor folliculi test tube thermostat of operating room Expired - Fee Related CN206587807U (en)

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CN201720180967.1U CN206587807U (en) 2017-02-28 2017-02-28 A kind of special liquor folliculi test tube thermostat of operating room

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Application Number Priority Date Filing Date Title
CN201720180967.1U CN206587807U (en) 2017-02-28 2017-02-28 A kind of special liquor folliculi test tube thermostat of operating room

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110090680A (en) * 2019-05-08 2019-08-06 白银市红十字中心血站 A kind of multi-functional Quality Control sample sample mixing instruction device in blood station
CN111715320A (en) * 2020-07-17 2020-09-29 清华大学 Array test tube positioner of quick fastening

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110090680A (en) * 2019-05-08 2019-08-06 白银市红十字中心血站 A kind of multi-functional Quality Control sample sample mixing instruction device in blood station
CN110090680B (en) * 2019-05-08 2021-01-05 白银市红十字中心血站 Blood station mixes appearance indicating device with multi-functional matter accuse sample
CN111715320A (en) * 2020-07-17 2020-09-29 清华大学 Array test tube positioner of quick fastening

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20171027

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