CN212395398U - A multichannel connecting line that is used for peripheral blood hemopoietic stem cell to freeze and deposits - Google Patents
A multichannel connecting line that is used for peripheral blood hemopoietic stem cell to freeze and deposits Download PDFInfo
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- CN212395398U CN212395398U CN202021666049.8U CN202021666049U CN212395398U CN 212395398 U CN212395398 U CN 212395398U CN 202021666049 U CN202021666049 U CN 202021666049U CN 212395398 U CN212395398 U CN 212395398U
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Abstract
The utility model discloses a multichannel connecting line for peripheral blood hematopoietic stem cell cryopreserving, pipeline include that pjncture needle, multichannel divide collector one, interpolation formula cross, female spiral joint of winged tape, multichannel divide collector two and interpolation formula two. The utility model discloses in, can realize sealing the operation after finishing pipe connection, both can realize the mixture of peripheral blood hematopoietic stem cell and cell cryoprotectant, can carry out quantitative partial shipment to the mixture through the syringe again, need not to puncture needle and syringe and puncture the plug operation repeatedly. In addition, the utility model discloses in, cancelled the pjncture needle in being connected with cell cryopreserving bag, adopt interpolation formula two-way disect insertion to cut off cell cryopreserving bag pipe internal formation closed tube way and carry out the mixture partial shipment.
Description
Technical Field
The utility model relates to a medical instrument, concretely relates to can rapid mixing peripheral blood hematopoietic stem cell and cell cryoprotectant to joinable syringe utilizes the multichannel connecting line of quick, the ration partial shipment mixture of syringe and application method thereof.
Background
The low-temperature cryopreservation of peripheral blood hematopoietic stem cells refers to a technology of fully mixing peripheral blood hematopoietic stem cells collected by a blood cell separator and a cell cryoprotectant and then freezing and storing in an ultra-low temperature refrigerator at minus 80 ℃ or a liquid nitrogen tank at minus 196 ℃. The technology is a key technology of autologous hematopoietic stem cell transplantation, and has become an effective method for treating malignant hematological diseases and various solid tumors. In the process, peripheral blood hematopoietic stem cells and a cell cryoprotectant are uniformly mixed in proportion in a low-temperature environment (0-4 ℃), and then the mixture is subpackaged into cell cryopreservation bags with the same or different models according to a certain volume. After the split charging is finished, the cell freezing bag filled with the mixture is spread in an ultra-low temperature refrigerator at minus 80 ℃ and is frozen into a thin layer with the thickness less than or equal to 0.5 cm, the operation is finished, and the cell freezing bag is moved to a liquid nitrogen tank at minus 196 ℃ after the next day to realize long-term storage.
Considering the various reasons such as the mobilization effect of peripheral blood hematopoietic stem cells of a patient, the time for collecting, the bearing capacity of the patient, the difficulty degree of freezing operation, the proportion of a cell freezing protective agent and the like, the single collection amount of the peripheral blood hematopoietic stem cells of the unit where the utility model is located is mostly three levels of 100mL, 150mL and 200 mL. The peripheral blood hematopoietic stem cells and the cell cryoprotectant are mixed according to the proportion of 1:2 (volume ratio), so that the cell cryoprotectant is used in three dosage of 200mL, 300mL and 400mL (the specification of the cell cryoprotectant is 100mL per bag). The volumes of the mixture after the peripheral blood hematopoietic stem cells and the cell cryoprotectant are respectively 300mL, 450mL and 600 mL. The mixture is subpackaged into cell freezing bags (100mL standard) according to 50mL per bag, and 6, 9 and 12 cell freezing bags are respectively needed. In clinical work, the number of cell cryoprotectants and cell cryopreservation bags is increased or decreased according to the actual collection amount of peripheral blood hematopoietic stem cells.
At present, a connecting pipeline used in the process of mixing peripheral blood hematopoietic stem cells and a cell cryoprotectant is very simple, and only two ends of one catheter are respectively connected with one puncture needle. The puncture needles at the two ends of the catheter are respectively inserted into an infusion apparatus socket of the peripheral blood hematopoietic stem cell collecting bag and an infusion apparatus socket of the cell freezing protective agent bag, then the cell freezing protective agent bag is suspended in a super-clean workbench, and the cell freezing protective agent can automatically flow into the peripheral blood hematopoietic stem cell collecting bag by utilizing gravity, so that the cell freezing protective agent bag and the peripheral blood hematopoietic stem cell collecting bag are mixed.
However, this process has some disadvantages:
1. in the process of mixing 4 bags of cell cryoprotectant with 1 bag of peripheral blood hematopoietic stem cells, the cell cryoprotectant is sequentially mixed with the peripheral blood hematopoietic stem cells, and a puncture needle connected with the cell cryoprotectant needs to be repeatedly inserted and pulled for 4 times.
2. The connecting pipeline can not carry out quantitative sub-packaging on the mixture, in the sub-packaging process, for accurately measuring the volume of the mixture in each cell cryopreservation bag, the connecting pipeline needs to be removed, the syringe is sleeved with the needle to pierce the insertion opening of the transfusion device of the peripheral blood hematopoietic stem cell collection bag to suck the mixture, then the catheter of the cell cryopreservation bag is pierced, and the mixture is injected into the cell cryopreservation bag. The process needs 12 times of reciprocating to complete the split charging of the mixture, so that the operation is complex and the danger is high. The infusion apparatus insertion opening of the peripheral blood hematopoietic stem cell collection bag is easy to damage and leak liquid to pollute the super-clean workbench after repeated puncture, and the finger of an operator is easy to be hurt and pollutants are brought in the process of puncturing the cell cryopreservation bag guide pipe.
3. The mixing and packaging process takes a long time, and when the ambient temperature is higher, the mixture has the possibility of warming, which is not favorable for the cryopreservation of peripheral blood hematopoietic stem cells.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a multichannel connecting line that is used for peripheral blood hematopoietic stem cell cryopreserving, pipeline simple structure, operation, convenient to use, low cost can be with the peripheral blood hematopoietic stem cell and the cell freezing protectant flash mixed of gathering again can be connected quick, the quantitative partial shipment mixture of syringe.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
a multi-channel connecting pipeline for cryopreserving peripheral blood hematopoietic stem cells comprises a puncture needle, a first multi-channel manifold, an internal-insertion four-way, a spiral joint with a wing nut, a second multi-channel manifold and an internal-insertion two-way;
the multi-channel diversity device I comprises a plurality of input channels for connecting puncture needles and an output channel for communicating with the interpolation type four-way through the liquid stopping clips; the puncture needle connected with the first multichannel diversity device is used for connecting the cell freezing protective agent bag;
the four connection channels of the interpolating quad are used for: the output channel of the first multi-channel manifold is connected through a liquid stopping clamp; the puncture needle is connected through the liquid stopping clamp; connecting a female screw joint with a wing; the input channel is connected with the second multi-channel collector;
the puncture needle connected with the interpolation type four-way is used for connecting the peripheral blood hematopoietic stem cell collecting bag; the winged female screw joint is used for connecting a syringe;
the second multi-channel diversity device comprises a plurality of output channels and an input channel, the output channels of the second multi-channel diversity device are respectively used for being connected with an interpolation type two-way through liquid stopping clamps, and the input channel of the second multi-channel diversity device is used for being connected with the interpolation type four-way;
the interpolation type two-way connector comprises two connecting channels, wherein one connecting channel is used for connecting an output channel of the multi-channel divider II, and the other connecting channel is used for being plugged into the tail end closed conduit in a pluggable mode; the other connecting channel of the interpolation type two-way can be inserted with the cell freezing bag conduit of the cell freezing bag after being pulled out from the tail end closed conduit.
Furthermore, a puncture needle protective cap is detachably sleeved on all the puncture needles.
Furthermore, a spiral protective cap is detachably sleeved on the winged female spiral connector.
Further, the first multi-channel diversity device comprises four input channels.
Further, the second multi-channel diversity device comprises twelve output channels.
The beneficial effects of the utility model reside in that:
the utility model discloses in, can realize sealing the operation after finishing pipe connection, both can realize the mixture of peripheral blood hematopoietic stem cell and cell cryoprotectant, can carry out quantitative partial shipment to the mixture through the syringe again, need not to puncture needle and syringe and puncture the plug operation repeatedly. In addition, the utility model discloses in, cancelled the pjncture needle in being connected with cell cryopreserving bag, adopt interpolation formula two-way disect insertion to cut off cell cryopreserving bag pipe internal formation closed tube way and carry out the mixture partial shipment.
Drawings
Fig. 1 is a schematic view of a pipeline structure according to embodiment 1 of the present invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings, and it should be noted that the present embodiment is based on the technical solution, and the detailed embodiments and the specific operation processes are provided, but the protection scope of the present invention is not limited to the present embodiment.
Example 1
The embodiment provides a multichannel connecting pipeline for cryopreserving peripheral blood hematopoietic stem cells, which comprises a puncture needle, a catheter, a first multichannel collector, an internal four-way connector, a female spiral connector with wings, a second multichannel collector and an internal two-way connector, as shown in fig. 1;
the multi-channel first manifold 17 comprises a plurality of input channels for connecting puncture needles 13, 14, 15 and 16 and an output channel for communicating with an inner inserting type four-way 20 through a liquid stopping clip 18; puncture needles 13, 14, 15 and 16 connected with the multi-channel manifold I17 are used for connecting cell cryoprotectant bags 1, 2, 3 and 4;
the four connection channels of the interpolating four-way 20 are used for: the output channel of the first multi-channel manifold 17 is connected through a liquid stopping clamp 18; a puncture needle 21 is connected through a liquid stopping clamp 19; a winged female screw joint 25 is connected; the input channel of the second multi-channel splitter 30 is connected;
the puncture needle 21 connected with the interpolation type four-way connector 20 is used for connecting a peripheral blood hematopoietic stem cell collecting bag 24; the winged female screw joint 25 is used for connecting a syringe 27;
the second multi-channel manifold 30 comprises a plurality of output channels and an input channel, the output channels of the second multi-channel manifold 30 are respectively connected with an interpolation two- way 32, 37, 42, 47, 52, 57, 62, 67, 72, 77, 82 and 87 through liquid stopping clips 31, 36, 41, 46, 51, 56, 61, 66, 71, 76, 81 and 86, and the input channel of the second multi-channel manifold 30 is used for connecting the interpolation four-way 20;
each two insert-in passages 32, 37, 42, 47, 52, 57, 62, 67, 72, 77, 82, 87 comprises two connecting passages, wherein one connecting passage is used for connecting the output passage of the second multi-passage manifold 30, and the other connecting passage is used for being inserted into the closed- end guide pipes 33, 38, 43, 48, 53, 58, 63, 68, 73, 78, 83, 88 in an inserting way; after the closed- end conduits 33, 38, 43, 48, 53, 58, 63, 68, 73, 78, 83, 88 are pulled out of the other connecting channel of the two insert passages 32, 37, 42, 47, 52, 57, 62, 67, 72, 77, 82, 87, the other connecting channel of the two insert passages 32, 37, 42, 47, 52, 57, 62, 67, 72, 77, 82, 87 can be inserted into the cell freezing bag conduits 34, 39, 44, 49, 54, 59, 64, 69, 74, 79, 84, 89 of the cut cell freezing bag.
In the embodiment, the puncture needle protective caps 9, 10, 11, 12, 22 are detachably sleeved on all the puncture needles 13, 14, 15, 16, 21.
In this embodiment, the winged female screw joint 25 is detachably sleeved with a screw cap 26.
In this embodiment, the first multi-channel collector 17 includes four input channels, which are respectively connected to four puncture needles. Four cell cryoprotectant bags can be connected through the four puncture needles.
In this embodiment, the second multi-channel splitter 30 includes twelve output channels. Twelve cell cryopreservation bags can be connected through the twelve output channels.
In the multi-channel connecting pipeline, a plurality of puncture needles of an input channel of the multi-channel manifold can be simultaneously inserted into the jacks of the infusion apparatus for the multiple bags of the cell freezing protective agents, so that the defect that only one puncture needle is sequentially inserted and pulled out among the multiple bags of the cell freezing protective agents in the prior art is overcome, the multiple bags of the cell freezing protective agents are sequentially mixed with peripheral blood hematopoietic stem cells and are simultaneously mixed, the mixing time is shortened, and unnecessary puncture operation is reduced.
An output channel of the first multi-channel manifold is connected with a first connecting channel of the inner inserting type four-way valve through a guide pipe, and a liquid stopping clamp is arranged on the connected guide pipe. The second connecting channel of the inner inserting type four-way is connected with another puncture needle through a guide pipe and is used for being inserted into an infusion apparatus socket of a peripheral blood hematopoietic stem cell collecting bag, and a liquid stopping clamp is also arranged on the connecting guide pipe. And the third connecting channel and the fourth connecting channel of the interpolation type four-way connector are respectively connected with the input channel of the winged female spiral connector and the input channel of the multi-channel manifold II through guide pipes.
The winged female screw joint is matched with a screw protective cap, a 50mL or 100mL syringe can be inserted into the winged female screw joint after the screw protective cap is unscrewed in a rotating mode, and the syringe is used for sucking the mixture of peripheral blood hematopoietic stem cells and cell cryoprotectants.
Each output channel of the second multi-channel manifold is connected with one of the connecting channels of the interpolation two-way manifolds through a conduit respectively, and the connected conduits are provided with liquid stopping clamps respectively; the other connecting channel of each of the two add-in passageways is connected to a shorter closed-end conduit. When in use, the catheter with the closed end can be pulled out, and the other connecting channel of each interpolation type two-way is inserted into the cut cell freezing bag catheter of each cell freezing bag.
Example 2
The embodiment provides a method for utilizing the multichannel connecting pipeline for peripheral blood hematopoietic stem cell cryopreservation, which specifically comprises the following steps:
s1, before use, all the liquid stopping clamps 18, 19, 31, 36, 41, 46, 51, 56, 61, 66, 71, 76, 81 and 86 are closed, and then all the puncture needle protective caps 9, 10, 11, 12 and 22 are pulled off;
inserting puncture needles 13, 14, 15 and 16 connected with a first multichannel collector 17 into infusion apparatus sockets 5, 6, 7 and 8 of four cell cryoprotectant bags 1, 2, 3 and 4 respectively, and inserting a puncture needle 21 connected with an interpolation-type four-way 20 into an infusion apparatus socket 23 of a peripheral blood hematopoietic stem cell collection bag 24;
cutting off the cell freezing bag conduit 34, 39, 44, 49, 54, 59, 64, 69, 74, 79, 84, 89 of each cell freezing bag 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, removing the end closing conduit 33, 38, 43, 48, 53, 58, 63, 68, 73, 78, 83, 88 connected to the other connecting channel of each interpolation two- way 32, 37, 42, 47, 52, 57, 62, 67, 72, 77, 82, 87, and then inserting the other connecting channel of each interpolation two-way into the cut cell freezing bag conduit 34, 39, 44, 49, 54, 59, 64, 69, 74, 79, 84, 89 of each cell freezing bag 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90;
screwing off the screw protective cap 26, and inserting the syringe 27 into the winged female screw joint 25; at this point, the connection is complete.
S2, suspending the cell freezing protective agent bags 1, 2, 3 and 4 in a superclean workbench, placing the peripheral blood hematopoietic stem cell collecting bag 24 on an ice row to keep low temperature, opening the liquid stopping clip 18 between the multi-channel first collector 17 and the inner four-way 20 and the liquid stopping clip 19 between the inner four-way 20 and the peripheral blood hematopoietic stem cell collecting bag 24, wherein the cell freezing protective agent flows into the peripheral blood hematopoietic stem cell collecting bag 24 through a pipeline under the action of gravity, and the peripheral blood hematopoietic stem cell collecting bag 24 is continuously shaken to fully mix the cell freezing protective agent and the peripheral blood hematopoietic stem cells.
S3, closing the liquid stopping clamp 18 between the multi-channel manifold I17 and the internal four-way 20 after the cell freezing protective agent and the peripheral blood hematopoietic stem cells are mixed, drawing the injector core rod 28 of the injector 27, and pumping the mixture of the peripheral blood hematopoietic stem cells and the cell freezing protective agent with set volume into the injector 27;
closing the liquid stopping clamp 19 between the internal four-way connector 20 and the peripheral blood hematopoietic stem cell collecting bag 24, opening the liquid stopping clamp 31 between one output channel of the multi-channel manifold two 30 and one internal two-way connector 32, pushing the injector core rod 28, pressing the mixture into the corresponding cell freezing bag 35, sealing the corresponding cell freezing bag conduit 34 by using a heat sealing machine, and cutting the sealing point to finish the first split charging;
the liquid stopping clip 19 between the inner inserting type four-way 20 and the peripheral blood hematopoietic stem cell collecting bag 24 is opened again, the syringe core rod 28 of the syringe 27 is drawn, and the mixture with the same volume is sucked into the syringe 27; closing the liquid stopping clamp 19 between the inner insertion type four-way connector 20 and the peripheral blood hematopoietic stem cell collecting bag 24, opening the liquid stopping clamp 36 between the other output channel of the multi-channel manifold two 30 and the other inner insertion type two-way connector 37, pushing the injector core rod 28, pressing the mixture into the corresponding cell freezing bag 40, then sealing the corresponding cell freezing bag conduit 39 by using a heat sealing machine and cutting the sealing point, thus completing the second sub-packaging;
and by analogy, the mixture is subpackaged into the rest cell freezing bags 45, 50, 55, 60, 65, 70, 75, 80, 85 and 90.
When the cell freezing bag is 100mL in size, a 50mL syringe may be used in combination, and when the cell freezing bag is 200mL in size and is dispensed, a 100mL syringe may be used in combination to reduce the number of times the mixture is aspirated. In this example, the specification of the cell cryoprotectant bag is 100mL, the specification of the peripheral blood hematopoietic stem cell collection bag is 1000mL, 200mL of the peripheral blood hematopoietic stem cell collection is contained therein, and the ratio of the total amount of the cryoprotectant to the total amount of the hematopoietic stem cells is 1:2, four bags of cell cryoprotectants are needed. Therefore, in this embodiment, a multi-channel diversity device with four input channels is used to connect four puncture needles and four bags of cell cryoprotectant. The multi-channel first manifold and the multi-channel second manifold with different channel numbers can be manufactured and used according to other specifications, mixing requirements and split charging requirements.
Various corresponding changes and modifications can be made by those skilled in the art according to the above technical solutions and concepts, and all such changes and modifications should be included in the protection scope of the present invention.
Claims (5)
1. A multi-channel connecting pipeline for cryopreserving peripheral blood hematopoietic stem cells is characterized by comprising a puncture needle, a first multi-channel collector, an internal insertion type four-way connector, a nut screw connector with wings, a second multi-channel collector and an internal insertion type two-way connector;
the multi-channel diversity device I comprises a plurality of input channels for connecting puncture needles and an output channel for communicating with the interpolation type four-way through the liquid stopping clips; the puncture needle connected with the first multichannel diversity device is used for connecting the cell freezing protective agent bag;
the four connection channels of the interpolating quad are used for: the output channel of the first multi-channel manifold is connected through a liquid stopping clamp; the puncture needle is connected through the liquid stopping clamp; connecting a female screw joint with a wing; the input channel is connected with the second multi-channel collector;
the puncture needle connected with the interpolation type four-way is used for connecting the peripheral blood hematopoietic stem cell collecting bag; the winged female screw joint is used for connecting a syringe;
the second multi-channel diversity device comprises a plurality of output channels and an input channel, the output channels of the second multi-channel diversity device are respectively connected with an interpolation two-way through liquid stopping clamps, and the input channel of the second multi-channel diversity device is used for connecting the interpolation four-way;
the interpolation type two-way connector comprises two connecting channels, wherein one connecting channel is used for connecting an output channel of the multi-channel divider II, and the other connecting channel is used for being plugged into the tail end closed conduit in a pluggable mode; the other connecting channel of the interpolation type two-way can be inserted with the cell freezing bag conduit of the cell freezing bag after being pulled out from the tail end closed conduit.
2. The multi-channel connecting pipeline for the cryopreservation of peripheral blood hematopoietic stem cells as claimed in claim 1, wherein a puncture needle protective cap is detachably sleeved on all puncture needles.
3. The multi-channel connecting pipeline for the cryopreservation of peripheral blood hematopoietic stem cells as claimed in claim 1, wherein a spiral protective cap is detachably sleeved on the winged female spiral connector.
4. The multi-channel connecting pipeline for the cryopreservation of peripheral blood hematopoietic stem cells of claim 1, wherein the first multi-channel diversity device comprises four input channels.
5. The multi-channel connecting pipeline for the cryopreservation of peripheral blood hematopoietic stem cells of claim 1, wherein the second multi-channel diversity device comprises twelve output channels.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202021666049.8U CN212395398U (en) | 2020-08-12 | 2020-08-12 | A multichannel connecting line that is used for peripheral blood hemopoietic stem cell to freeze and deposits |
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| CN202021666049.8U CN212395398U (en) | 2020-08-12 | 2020-08-12 | A multichannel connecting line that is used for peripheral blood hemopoietic stem cell to freeze and deposits |
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