CN212214206U - Soft capsule preparation system - Google Patents

Soft capsule preparation system Download PDF

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Publication number
CN212214206U
CN212214206U CN202020003077.5U CN202020003077U CN212214206U CN 212214206 U CN212214206 U CN 212214206U CN 202020003077 U CN202020003077 U CN 202020003077U CN 212214206 U CN212214206 U CN 212214206U
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liquid medicine
glue solution
liquid
soft capsule
tank
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CN202020003077.5U
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胡亦乐
丁统帅
朱振羽
黄文杰
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Shanghai Sine Yan'an Pharmaceutical Co ltd
Shanghai Sine Wanxiang Pharmaceutical Co ltd
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Shanghai Sine Yan'an Pharmaceutical Co ltd
Shanghai Sine Wanxiang Pharmaceutical Co ltd
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Priority to CN202020003077.5U priority Critical patent/CN212214206U/en
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Abstract

The utility model discloses a soft capsule preparation system, including liquid medicine piece forming system and capsule body forming system, wherein: the liquid medicine block forming system comprises a plurality of moulds, an automatic feeder, an automatic rod inserting machine and a low-temperature brine tank, wherein the automatic feeder is used for quantitatively injecting liquid medicine into each mould according to the prescription amount; the low-temperature brine tank is used for freezing and solidifying the liquid medicine in the mould into liquid medicine blocks; the capsule blank forming system comprises a glue solution tank and a glue solution pool, wherein the bottom of the glue solution tank is communicated with the lower part of the glue solution pool through a liquid inlet pipeline; and transferring the frozen liquid medicine blocks in the low-temperature brine tank to a liquid medicine pool for coating treatment so as to form a gel skin on the surfaces of the liquid medicine blocks. The soft capsule preparation system has the advantages of high automation degree, simple and efficient process flow, high finished product control rate and low production cost, and realizes the efficient production of soft capsule dosage forms with thicker liquid medicine; and the amount of waste gelatin generated by the method is small, the unit consumption of the gelatin is obviously reduced, and the method is economical and practical.

Description

Soft capsule preparation system
Technical Field
The utility model relates to a medicine preparation technical field especially relates to a soft capsule preparation system.
Background
The soft capsule has been developed rapidly in China since the last 80 th century, the equipment is continuously updated, the variety and the yield are continuously increased, and the development of the Chinese medicinal soft capsule is also hot. The existing soft capsule manufacturing process is mainly a dropping method and a rotary die pressing method, and when the concentration of liquid medicine in a partial variety of prescriptions is higher (namely the solid particle content of suspension liquid medicine is higher and the suspension liquid medicine is more viscous), problems such as injector blockage and the like occur frequently or production cannot be directly carried out, so that the production efficiency and the variety expansion of soft capsule products are seriously influenced.
In addition, the pressing method can generate a large amount of mesh glue, and the recycling difficulty is high, so that a lot of production cost is increased. The dropping method has relatively slow production speed, complex process flow, poor forming when the loading is more than 200mg and great difficulty in product control. Therefore, there is a need for improvements to existing soft capsule preparation systems.
SUMMERY OF THE UTILITY MODEL
The utility model discloses the technical problem that will solve is: aiming at the defects of capsule preparation production when the concentration of liquid medicine in the existing prescription is thicker, the soft capsule preparation system which is simple and efficient in process flow, high in finished product control rate and low in production cost is provided, so that the efficient production of the soft capsule preparation with thicker liquid medicine is realized.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
the utility model provides a soft capsule preparation system, including being used for freezing liquid medicine low temperature for the liquid medicine piece forming system of liquid medicine piece with be used for liquid medicine piece surface package glue solution forms the capsule body forming system of rubber, wherein:
the liquid medicine block forming system comprises a plurality of moulds, an automatic feeder, an automatic rod inserting machine and a low-temperature brine tank, wherein the automatic feeder is used for quantitatively injecting liquid medicine into each mould according to the prescription amount; the automatic rod inserting machine is used for inserting a transfer rod into the liquid medicine or the liquid medicine block from the top of the mold; the low-temperature brine tank is used for freezing and solidifying the liquid medicine in the mold into liquid medicine blocks;
the capsule blank forming system comprises a glue solution tank and a glue solution pool, wherein the bottom of the glue solution tank is communicated with the lower part of the glue solution pool through a liquid inlet pipeline; and transferring the liquid medicine blocks frozen in the low-temperature brine tank to the glue solution tank for coating treatment so as to form a rubber on the surface of the liquid medicine blocks.
Furthermore, in the soft capsule preparation system, the mold is composed of two openable hemispherical structures, a circular notch is arranged at the center of the top, and an automatic opening and closing mechanism for controlling the opening and closing of the two hemispherical structures is arranged at the bottom.
Further, in the soft capsule preparation system, a plurality of the molds are sequentially arranged on a conveying belt of a production line through the automatic opening and closing mechanism at the bottom of the molds.
Further, in the soft capsule preparation system, the transfer rod is a stainless steel rod or a gelatin rod.
Further, in the soft capsule preparation system, the liquid medicine block molding system further comprises a manipulator for transferring the glue to the liquid glue pool for gluing.
Further, in the soft capsule preparation system, the capsule blank forming system further comprises a liquid level tank connected with the upper part of the glue solution tank through a circulating pipeline, and the bottom of the liquid level tank is connected with the liquid inlet pipeline through a pipeline, so that the glue solution collected in the liquid level tank is conveyed into the glue solution tank again for recycling.
Further preferably, in the soft capsule preparation system, the bottom of the liquid level tank is connected to the liquid inlet pipeline through a circulating liquid valve via a pipeline.
Further, in the soft capsule preparation system, a circulating pump is arranged on the liquid inlet pipeline close to the glue pool; and a liquid inlet valve is arranged on the liquid inlet pipeline and close to the glue liquid tank.
Further, in the soft capsule preparation system, an ultrasonic level meter for detecting the residual amount of the glue solution is arranged on the glue solution tank.
Further, in the soft capsule preparation system, the capsule blank forming system further comprises an air cooler for cooling and shaping the liquid medicine block subjected to glue coating in the glue solution pool.
The above technical scheme is adopted in the utility model, compared with the prior art, following technological effect has:
(1) compared with the existing dripping method and pressing method, the preparation system has small requirements on the physical properties, the loading amount and the like of the liquid medicine due to the filling of the feeder, so that soft capsules can be smoothly and efficiently prepared from products with thick liquid medicine, the application range is wider, and the various developments of the soft capsule varieties are promoted;
(2) compared with a pressing method, a large amount of net glue is generated, the recycling difficulty is high, and a lot of production cost is increased; the preparation system has the advantages that the waste glue generated by the preparation system is small, the unit consumption of the gelatin is obviously reduced, and the preparation system is economical and practical;
(3) compared with a dripping method, the production speed is relatively slow, and the forming is poor when the filling amount is more than 200 mg; the preparation system adopts mechanical automation continuous production, the process flow is simple and efficient, and compared with the prior art, the production speed and efficiency are improved, and the product control difficulty is reduced;
(4) the preparation system does not need to use extra materials such as cooling liquid, lubricating oil and the like, reduces the cost, obtains the semi-finished product of the soft capsule with clean surface, does not need extra steps such as washing the soft capsule and the like, does not have other material residues, and improves the production efficiency;
(5) the preparation system has high automation degree, can reduce operators in the production process, reduces the labor cost, is favorable for the aspects of microbial control and the like, and strengthens the product quality control.
Drawings
FIG. 1 is a flow chart of a process for forming a liquid block of Chinese herbs in a system for preparing a soft capsule of the present invention;
FIG. 2 is a process flow chart of the capsule blank forming in the soft capsule preparation system of the present invention;
FIG. 3 is a schematic structural view of a glue tank in the capsule blank forming process in the soft capsule preparation system of the present invention;
wherein the reference symbols are:
1-mould, 2-automatic feeder, 3-automatic rod inserting machine, 4-low temperature brine tank, 5-manipulator, 6-glue tank, 7-glue tank, 8-liquid level tank, 9-liquid inlet pipeline, 10-circulating pipeline, 11-liquid inlet valve, 12-circulating liquid valve, 13-circulating pump, 14-transfer rod, 15-ultrasonic level instrument.
Detailed Description
The present invention will be described in detail and specifically with reference to specific embodiments so as to provide a better understanding of the present invention, but the following embodiments do not limit the scope of the present invention.
Referring to fig. 1 and 2, the present embodiment provides a system for preparing a soft capsule preparation, including a liquid medicine block forming system for freezing a liquid medicine into a liquid medicine block at a low temperature and a capsule blank forming system for wrapping a liquid glue on the surface of the liquid medicine block to form a rubber, and the main technical scheme is to freeze the liquid medicine into a solid liquid medicine block at a low temperature, and then wrap the liquid glue on the surface of the solid medicine block to form a rubber to prepare the soft capsule preparation, thereby realizing efficient production of a soft capsule preparation with a thick liquid medicine.
In the present embodiment, please refer to fig. 1, the liquid medicine block forming system includes a plurality of molds 1, an automatic feeder 2, an automatic rod inserting machine 3, and a low-temperature brine tank 4, wherein the automatic feeder 2 is configured to quantitatively inject liquid medicine into each mold 1 according to a prescribed amount; the automatic rod inserting machine 3 is used for inserting a transfer rod 14 into the liquid medicine or the liquid medicine block from the top of the mold 1, and the transfer rod 14 is a stainless steel rod or a gelatin rod; the low-temperature brine tank 4 is used for freezing and solidifying the liquid medicine in the mould 1 into a liquid medicine block.
In this embodiment, please refer to fig. 2, the capsule blank forming system includes a glue solution tank 6 and a glue solution tank 7, and the bottom of the glue solution tank 6 is communicated with the lower portion of the glue solution tank 7 through a liquid inlet pipe 9; and transferring the liquid medicine blocks frozen in the low-temperature brine tank 4 to the glue solution tank 7 for coating treatment so as to form a rubber on the surface of the liquid medicine blocks.
In this embodiment, please refer to fig. 1, the mold 1 is composed of two openable hemispherical structures, the mold 1 is ellipsoidal or spherical, and has a circular notch at the top center and an automatic opening and closing mechanism at the bottom for controlling the opening and closing of the two hemispherical structures. The plurality of moulds 1 are sequentially arranged on a conveying belt of the production line through the automatic opening and closing mechanisms at the bottoms of the moulds.
In the present embodiment, please refer to fig. 1, an automatic feeder 2 is used to fill the liquid medicine into the mold 1; the soft capsules are filled by the feeder 2, so that the requirements on the physical properties, the filling quantity and the like of the liquid medicine are low, the soft capsules can be smoothly and efficiently prepared from products with thick liquid medicine, the application range is wider, and the various developments of the soft capsule varieties are promoted.
In this embodiment, after the liquid medicine is frozen in the low-temperature brine tank 4, the mold 1 is sprayed with 20-30 ℃ demolding water to separate the liquid medicine block from the mold 1. The low-temperature brine tank 4 is a low-temperature brine tank.
In this embodiment, as shown in fig. 1, the liquid medicine block forming system further includes a manipulator 5 for transferring the glue block to the glue pool 7 for gluing.
In this embodiment, please refer to fig. 2, the capsule blank forming system further includes a liquid level tank 8 connected to the upper portion of the glue solution tank 7 through a circulation pipeline 10, and the bottom of the liquid level tank 8 is connected to the liquid inlet pipeline 9 through a pipeline, so as to transport the glue solution collected in the liquid level tank 8 to the glue solution tank 7 again for recycling.
In this embodiment, as shown in fig. 2, the bottom of the liquid level tank 8 is connected to the liquid inlet pipe 9 through a circulating liquid valve 12. A circulating pump 13 is arranged on the liquid inlet pipeline 9 close to the glue liquid pool 7; and a liquid inlet valve 11 is arranged on the liquid inlet pipeline 9 and close to the glue solution tank 6.
In this embodiment, please refer to fig. 3, an ultrasonic level meter 15 for detecting the remaining amount of the glue solution is disposed on the glue solution tank 6. The distance between the ultrasonic level meter 15 and the axis feed inlet at the top of the glue solution tank 6 is 2/3 the radius of the glue solution tank 6, namely the distance between the ultrasonic level meter 15 and the edge of the glue solution tank 6 is 1/3 the radius of the glue solution tank 6. Through setting up the ultrasonic wave position appearance 15 that is used for detecting the glue solution surplus at glue solution jar 6 top, through ultrasonic wave position appearance 15's probe, form ultrasonic pulse and detection echo, ultrasonic pulse ripples is propagated away from the surface of probe with certain toper wavefront, especially to the glue solution of the calm no ripples in surface, and the ultrasonic measurement will obtain the best effect to this knows glue solution surplus in glue solution jar 6.
In this embodiment, please refer to fig. 2, the capsule blank forming system further includes an air cooler for cooling and shaping the liquid medicine block after the glue is applied to the glue solution tank 7, the air cooler cools and shapes the capsule blank, removes the transfer rod on the capsule blank, seals the part of the top end of the capsule blank protruding out of the pellet, and performs subsequent processes such as drying to obtain the soft capsule preparation.
In this embodiment, when applied to a part of soft capsule health products, the auxiliary materials can be printed or wrapped on the incompletely solidified surface of the capsule blank, so as to improve the effects of the soft capsule preparation, such as color value, taste and nutritive value, and facilitate sale.
The process principle of the soft capsule preparation system provided by the embodiment is as follows:
continuing to refer to fig. 1, in a flow-line operation mode, the liquid medicine is quantitatively injected into each mold 1 from the liquid medicine tank through the automatic feeding pipe 2 according to the prescription amount, and then the stainless steel thin rod 14 is inserted into the liquid medicine from the top gap of the mold 1 through the automatic rod inserting machine 3; then the liquid medicine is operated to pass through a low-temperature brine tank 4 with the concentration of 28-32 DEG Be and the temperature of-28 to-32 ℃, and the liquid medicine is solidified and molded from outside to inside at low temperature; and after the liquid medicine is completely solidified and formed, the low-temperature brine tank 4 is operated, a small amount of demoulding water with the temperature of 20-30 ℃ is sprayed on the outer surface of the mould to separate the liquid medicine blocks from the mould so as to facilitate smooth demoulding of the liquid medicine blocks, then the spliced mould is opened, and the mechanical arm 5 grabs the liquid medicine blocks in rows and enters the next working section.
Continuing to refer to fig. 2, the prepared glue solution is input into the glue solution pool 7 from the glue solution tank 6 through the liquid inlet pipeline 9 and the circulating pump 13, and when the liquid level of the glue solution reaches a certain height, the glue solution overflows and flows into the liquid level tank 8 through the circulating liquid pipeline 10, so that the glue solution in the glue solution pool 7 can be kept in a fixed liquid level height and temperature range; when the glue solution in the liquid level tank 8 is accumulated to a certain amount, the liquid inlet valve 11 is closed, the circulating liquid valve 12 is opened, and the glue solution in the liquid level tank 8 is injected into the glue solution tank 7 again; after the glue solution in the liquid level tank 8 is placed to the lowest liquid level height, the circulating liquid valve 12 is closed, the liquid inlet valve 11 is opened, and the glue solution is input into the glue solution tank 7 again from the glue solution tank 6; the manipulator 5 is operated to the upper part of the glue solution pool 7, the liquid medicine block is immersed into the glue solution pool 7 to a proper depth and then taken out, and the liquid medicine block is coated and hung uniformly; then, the rubber is preliminarily shaped after running through an air supply section of an air cooler through a manipulator 5, and is placed into a groove of the production line in an aligned mode; when the liquid medicine is properly melted, the rubber sheet adhered on the stainless steel bar is peeled off by the mechanical arm 5, and the stainless steel bar is drawn out.
According to the soft capsule preparation system provided by the embodiment, the capsule blank coated with the glue solution is operated through the sealing device in a flow line mode, a circle of rubber protruding out of the surface of the capsule blank is pressed through the heating plate, the redundant part is cut off, and then the pressing opening is polished to be smooth, so that a semi-finished product is obtained. Collecting the semi-finished product from the groove of the production line, and performing post-processes such as drying to finally obtain the required soft capsule product.
The above detailed description of the embodiments of the present invention is only for exemplary purposes, and the present invention is not limited to the above described embodiments. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, variations and modifications in equivalents may be made without departing from the spirit and scope of the invention, which is intended to be covered by the following claims.

Claims (10)

1. The soft capsule preparation system is characterized by comprising a liquid medicine block forming system for freezing liquid medicine into a liquid medicine block at a low temperature and a capsule blank forming system for wrapping the surface of the liquid medicine block with liquid glue to form a rubber sheet, wherein:
the liquid medicine block forming system comprises a plurality of moulds (1), an automatic feeder (2), an automatic rod inserting machine (3) and a low-temperature brine pond (4), wherein the automatic feeder (2) is used for quantitatively injecting liquid medicine into each mould (1) according to the prescription amount; the automatic rod inserting machine (3) is used for inserting a transfer rod (14) into the liquid medicine or the liquid medicine block from the top of the mould (1); the low-temperature brine tank (4) is used for freezing and solidifying the liquid medicine in the mould (1) into liquid medicine blocks;
the capsule blank forming system comprises a glue solution tank (6) and a glue solution pool (7), wherein the bottom of the glue solution tank (6) is communicated with the lower part of the glue solution pool (7) through a liquid inlet pipeline (9); and the liquid medicine blocks frozen in the low-temperature brine tank (4) are transferred to the glue solution tank (7) for coating treatment, so that a rubber is formed on the surface of the liquid medicine blocks.
2. The system for preparing soft capsule formulation according to claim 1, wherein the mold (1) is composed of two openable and closable semispherical structures, a circular notch is provided at the center of the top, and an automatic opening and closing mechanism for controlling the opening and closing of the two semispherical structures is provided at the bottom.
3. The system for preparing soft capsule formulation according to claim 2, wherein a plurality of said molds (1) are sequentially disposed on an in-line conveyor by said automatic opening and closing mechanism at the bottom thereof.
4. The soft capsule preparation system of claim 1, wherein the transfer rod (14) is a stainless steel rod or a gelatin rod.
5. The system for preparing soft capsule formulations according to claim 1, characterized in that the system for forming the mass of liquid medicine further comprises a robot (5) for transferring the mass of glue to the glue bath (7) for gluing.
6. The soft capsule preparation system of claim 1, wherein the capsule blank forming system further comprises a liquid level tank (8) connected to the upper part of the glue solution tank (7) through a circulation pipeline (10), and the bottom of the liquid level tank (8) is connected to the liquid inlet pipeline (9) through a pipeline, so as to transport the glue solution collected in the liquid level tank (8) to the glue solution tank (7) for recycling.
7. The system for preparing soft capsule formulation according to claim 6, wherein the bottom of the liquid level tank (8) is connected to the liquid inlet pipe (9) through a circulating liquid valve (12) by a pipe.
8. The system for preparing soft capsule formulations according to claim 1, characterized in that a circulation pump (13) is provided on the liquid inlet duct (9) in the vicinity of the glue bath (7); and a liquid inlet valve (11) is arranged on the liquid inlet pipeline (9) and close to the glue tank (6).
9. The system for preparing the soft capsule preparation according to claim 1, wherein the glue solution tank (6) is provided with an ultrasonic level meter (15) for detecting the balance of the glue solution.
10. The system for preparing the soft capsule preparation according to claim 1, wherein the capsule blank forming system further comprises an air cooler for cooling and shaping the liquid medicine block after the glue is applied to the liquid medicine pool (7).
CN202020003077.5U 2020-01-02 2020-01-02 Soft capsule preparation system Active CN212214206U (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116585197A (en) * 2023-06-16 2023-08-15 广州顾元化妆品有限公司 Automatic feeding device for producing essence of cosmetic soft capsules and soft capsule production process thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116585197A (en) * 2023-06-16 2023-08-15 广州顾元化妆品有限公司 Automatic feeding device for producing essence of cosmetic soft capsules and soft capsule production process thereof
CN116585197B (en) * 2023-06-16 2023-11-10 广州顾元化妆品有限公司 Automatic feeding device for producing essence of cosmetic soft capsules and soft capsule production process thereof

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