CN212159824U - Immunoassay box - Google Patents
Immunoassay box Download PDFInfo
- Publication number
- CN212159824U CN212159824U CN202020924996.6U CN202020924996U CN212159824U CN 212159824 U CN212159824 U CN 212159824U CN 202020924996 U CN202020924996 U CN 202020924996U CN 212159824 U CN212159824 U CN 212159824U
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- Prior art keywords
- sample
- test paper
- hole
- thick bamboo
- paper
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- 238000003018 immunoassay Methods 0.000 title claims description 20
- 238000012360 testing method Methods 0.000 claims abstract description 78
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 29
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 29
- 241001330002 Bambuseae Species 0.000 claims abstract description 29
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 29
- 239000011425 bamboo Substances 0.000 claims abstract description 29
- 238000005070 sampling Methods 0.000 claims abstract 2
- 238000001514 detection method Methods 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 11
- 238000001125 extrusion Methods 0.000 claims description 8
- 230000000903 blocking effect Effects 0.000 claims description 6
- 229910003460 diamond Inorganic materials 0.000 claims description 3
- 239000010432 diamond Substances 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 238000003317 immunochromatography Methods 0.000 description 4
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Images
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The application discloses an immunodetection box in the clinical examination immunity related technology field, box and a sample application section of thick bamboo at the bottom of including the paper test disc, the center department at box top at the bottom of the paper test disc is located to the sample application section of thick bamboo, be equipped with a plurality of on the box at the bottom of the paper test disc and encircle the test paper recess that adds a sample application section of thick bamboo, the embedded test paper that is equipped with of test paper recess, be equipped with on the section of thick bamboo wall that adds a sample application section of thick bamboo with the test paper recess just right sample hole, the outside that goes out sample hole is equipped with the slider that a plurality of blockked up out sample hole, slider and the slide connection in the vertical direction of the section of thick bamboo wall that adds a sample application section of thick bamboo. The scheme can be used for synchronously detecting a plurality of items, and can also be used for selecting to detect only one part of items according to requirements, and the items at the position can not be detected by moving the sliding block to block the sampling hole at the position.
Description
Technical Field
The utility model belongs to the technical field of clinical examination immunity is relevant, concretely relates to immunoassay box.
Background
With the continuous development of medical technology, the immunoassay technology is in a general application trend and is widely applied to species identification, disease detection and treatment and the like. The detection test paper utilizes the principle of antigen-antibody specific binding, has the advantages of high sensitivity, simple and convenient operation, portability and the like, and is generally applied to detection technology. However, in actual work, one test paper can only detect one substance at a time, and detection is often required to be repeated for many times during detection and diagnosis of complex diseases, so that the defects of long consumed time, inconvenience in operation and the like exist.
In view of this, prior art CN101261270B discloses an immunochromatographic multiple detection test paper tray, which includes a test paper tray bottom case, a test paper tray upper cover that can be covered with the test paper tray bottom case, and a drainage sheet that is arranged between the test paper strip on the test paper tray and the test paper tray upper cover, the test paper tray upper cover is provided with a sample adding hole, and the sample adding hole is right opposite to the drainage sheet, the sample adding hole is communicated with a drainage groove that is arranged on the inner surface of the upper cover and is composed of a plurality of drainage channels, the bottom case is provided with a plurality of drainage channel positions and test paper strip bearing tables corresponding to the number of the upper cover, and the edge of the drainage sheet is lapped on the sample pad of the test paper strip that is borne on the test paper strip bearing table and is close to one end of. The utility model also provides an utilize the method that the test paper dish carries out multiple detection of immunochromatography can realize carrying out the operation of once testing and accomplishing the while of multiple target by the thing to a sample and detect, promptly "one to many" detection mode for multiple immunochromatography test paper can be synchronous even emergence immunochromatography reaction and carry out many indexes to a sample and detect. However, the above-mentioned apparatus can only detect all the test strips at the same time, and when only partial detection is required, some test strips or drainage sheets need to be taken out to select and detect several indexes therein as required, which is more complicated for people unfamiliar with the apparatus and is also easy to contaminate the test strips.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to overcome the not enough of prior art existence, provide one kind can random selection detect wherein several kinds of inspection indexes or detect project immunodetection box.
The utility model provides a, an immunoassay box, box and a sample adding section of thick bamboo at the bottom of the test paper dish, its characterized in that: the sample adding cylinder is positioned at the center of the top of the test paper disc bottom box, a plurality of test paper grooves surrounding the sample adding cylinder are formed in the test paper disc bottom box, detection test paper is embedded in the test paper grooves, sample outlet holes opposite to the test paper grooves are formed in the cylinder wall of the sample adding cylinder, a plurality of sliding blocks blocking the sample outlet holes are arranged outside the sample outlet holes, the sliding blocks are connected with the cylinder wall of the sample adding cylinder in a sliding mode in the vertical direction, capillary tubes communicated with the sample outlet holes penetrate through the sliding blocks, and tube orifices at one end, far away from the sample outlet holes, of the capillary tubes are positioned right above the detection test paper.
The utility model discloses a theory of operation: the utility model discloses a based on prior art's scheme is improved, load test paper in the test paper recess, add a sample section of thick bamboo and be located the central point department of putting at test paper dish bottom box top, can be fixed also can not be fixed with a sample section of thick bamboo, shift up or move down the slider, make capillary and the play sample hole on the slider stagger, the wall and the laminating of a sample hole of slider, the jam goes out the sample hole, prevent the weeping, prepare to accomplish the back, wait for the sample with the preface and add a sample into a sample section of thick bamboo, it needs to use which several test paper promptly to make clear need the project that detects, just remove the slider that should locate with it corresponds, make capillary and sample hole intercommunication, wait to wait that the sample flows to the capillary in through the sample hole, from the dropwise add the test paper of capillary again, accomplish the detection that needs, the dropping sample finishes, remove the slider, it can prevent to wait to examine the sample and flow to.
The utility model has the advantages that: the utility model discloses an immunoassay box can carry out the detection of a plurality of projects in step, also can select only to detect some projects as required, moves the application of sample hole that plugs up this department with the slider and just can not detect the project of this department, compares in prior art, and this scheme is flexible more, simple and easy operation.
Preferably, an elastic plug for plugging the sample adding hole is arranged on the inner wall of the sliding block and above or below the capillary tube. In order to strengthen the blocking effect on the sample outlet hole, an elastic plug which is positioned in the same vertical direction with the capillary tube is arranged on the sliding block, the elastic plug is conical and is connected with the sliding block through a spring, when the sliding block moves up or moves down, the spring on the elastic plug is compressed, when the elastic plug moves to the sample outlet hole, the spring is released, the elastic plug blocks the sample outlet hole, and the sample to be detected is prevented from flowing out.
Further, the capillary inclines towards test paper one side, and inclination is 5 ~ 30. To accelerate the flow rate of the sample to be examined, the capillary is set to be inclined.
Furthermore, the sample adding cylinder is detachably connected with the paper test disc bottom box, and a clamping groove for inserting or screwing the sample adding cylinder into is formed in the center of the top of the paper test disc bottom box. In order to limit the sample adding cylinder and facilitate taking out, a clamping groove is preferably arranged on the paper test disc bottom box, and the sample adding cylinder is limited on the paper test disc bottom box through clamping or threaded connection.
Further, the bottom of adding a kind of section of thick bamboo is equipped with out the liquid hole, be equipped with the end cap that is used for blockking up out the liquid hole on going out the liquid hole, the bottom of adding a kind of section of thick bamboo is equipped with the inner groovy that is used for placing the end cap. In order to facilitate the cleaning of the sample adding cylinder and the discharge of waste liquid, the bottom of the sample adding cylinder is provided with an inner groove and a liquid outlet hole, and the liquid outlet hole is blocked by the plug.
Further, the inner wall sliding connection of a sample adding cylinder has an extrusion piston, be equipped with the application of sample hole with application of sample cylinder intercommunication on the extrusion piston, be equipped with the stopper on the application of sample hole. In order to accelerate the flow rate of the sample to be detected and the effect of cleaning, a piston is arranged to extrude the sample adding cylinder.
Further, the outside cover of adding a sample section of thick bamboo is equipped with the sleeve, and telescopic inner wall and the outer wall contact of adding a sample section of thick bamboo, be equipped with on the sleeve with go out the extension hole of appearance hole coincidence, the slider sets up on telescopic outer wall, and with sleeve sliding connection, capillary and extension hole intercommunication. In order to facilitate the processing of the equipment, the influence on the sample adding barrel is avoided, and the sliding of the sliding block is ensured, so that a sleeve is sleeved outside the sample adding barrel, a sliding groove is processed on the sleeve, and the sliding of the sliding block is facilitated.
Furthermore, the elastic plugs which block the sample outlet holes are arranged on the sleeve and positioned on the circle center connecting line of the plurality of extension holes, and the elastic plugs are connected with the sleeve through springs. Because a sleeve is additionally arranged, an elastic plug which is the same as the sliding block is arranged on the sleeve to plug the sample outlet hole.
Further, a cover is arranged at the upper part of the test paper disc bottom box. The cover is arranged to cover the immunoassay box, so that the immunoassay box is dustproof and anti-pollution.
Further, the shape of the paper tray bottom box is circular, square, diamond or regular polygon. The shape of the material can be any geometric shape such as a circle, a square, a diamond, a regular polygon and the like; the test paper recess has N, and N is the natural number. Therefore, N is preferably 4 to 8.
The detection test paper is a detection test paper or a detection box of a colloidal gold method, the colloidal gold method is a common marking technology, and the colloidal gold is used as a tracing marker to be applied to a novel immune marking technology of an antigen antibody, so that the colloidal gold detection kit has unique advantages. Have been widely used in various biological studies in recent years. The immunoblotting technique used in clinical practice almost exclusively uses its markers. And can be used in flow, electron microscope, immunity, molecular biology and biochip. The specific colloidal gold immunochromatography method comprises the steps of fixing specific antigen or antibody on a membrane in a strip shape, adsorbing a colloidal gold labeled reagent (antibody or monoclonal antibody) on a binding pad, moving forward through capillary action after a sample to be detected is added on the sample pad at one end of a test strip, dissolving the colloidal gold labeled reagent on the binding pad, reacting with each other, moving to a region of the fixed antigen or antibody, specifically binding the conjugate of the object to be detected and the gold labeled reagent with the conjugate, retaining the conjugate, and gathering the conjugate on a detection strip, so that a color development result can be observed through naked eyes. The method is developed into a diagnostic test strip, and is very convenient to use.
Drawings
FIG. 1 is a top view of an immunoassay cassette according to an embodiment of the present invention;
FIG. 2 is a cross-sectional view A-A of FIG. 1;
fig. 3 is a top view of the sleeve.
Detailed Description
The following is further detailed by way of specific embodiments:
reference numerals in the drawings of the specification include: the device comprises a paper disc bottom box 1, a test paper groove 2, a capillary tube 3, a sliding block 4, a sleeve 5, a sample adding cylinder 6, an extrusion piston 7, a plug 8, a liquid outlet hole 9 and an elastic plug 51.
The embodiment is basically as shown in the attached figures 1-2: an immunoassay box in this scheme, remove the lid, box 1 and application of sample section of thick bamboo 6 at the bottom of including the paper test disc, 6 one end openings of application of sample section of thick bamboo, the shape of box 1 at the bottom of the paper test disc is circular, an application of sample section of thick bamboo 6 is located the center department at 1 top of the box at the bottom of the paper test disc, the center department at 1 top of the box at the bottom of the paper test disc is equipped with the draw-in groove that supplies application of sample section of thick bamboo 6 to insert or the screw in, the bottom of application of sample section of thick bamboo 6 is equipped with liquid outlet 9, be equipped with the end cap that is used for blockking. The paper disc bottom box 1 is provided with 8 test paper grooves 2 surrounding the sample adding cylinder 6, different test paper is embedded in the test paper grooves 2, a sample outlet hole opposite to the test paper grooves 2 is arranged on the cylinder wall of the sample adding cylinder 6, the outer part of the sample adding cylinder 6 is sleeved with a sleeve 5, the inner wall of the sleeve 5 is contacted with the outer wall of the sample adding cylinder 6, the sleeve 5 is provided with an extension hole superposed with the sample outlet hole, the slide block 4 is arranged on the outer wall of the sleeve 5, and with sleeve 5 sliding connection, the outside of extension hole is equipped with the slider 4 that a plurality of blockked up the extension hole, slider 4 and sleeve 5's section of thick bamboo wall upward sliding connection in the vertical direction, run through on the slider 4 have with go out the capillary 3 of appearance hole and extension hole intercommunication, capillary 3 is fixed on slider 4, capillary 3 keeps away from the one end mouth of pipe in appearance hole and is located test paper directly over, capillary 3 inclines towards test paper one side, inclination is 15. On the inner wall of slider 4 and be in the top of capillary 3 or be equipped with the elasticity end cap 51 of blockking up the extension hole below, through spring coupling between elasticity end cap 51 and the slider 4, the inner wall sliding connection of application of sample section of thick bamboo 6 has extrusion piston 7, is equipped with the application of sample hole with application of sample section of thick bamboo 6 intercommunication on the extrusion piston 7, is equipped with stopper 8 on the application of sample hole.
As shown in fig. 3, an elastic plug 51 for blocking the sample outlet is also disposed on the inner wall of the sleeve 5 and on the connection line of the centers of the plurality of extending holes, and the elastic plug 51 is connected to the sleeve 5 through a spring.
The detection test paper is a colloidal gold method detection test paper.
The embodiment 2 is different from the embodiment 1 only in that the sleeve 5 is not arranged outside the sample adding cylinder 6, the slide block 4 is directly connected on the outer wall of the sample adding cylinder 6 in a sliding way, and the detection test paper is a detection box of a colloidal gold method.
The specific implementation process is as follows: in general use, as in example 1, the cover is removed, the slider 4 is moved up or down, the sleeve 5 is rotated to make the elastic plug 51 on the slider 4 and the elastic plug 51 on the sleeve 5 respectively plug the extension hole and the sample outlet hole, the extruding piston 7 is loaded into the sample loading cylinder 6, the plug 8 is opened, the sample to be tested is loaded into the sample loading cylinder 6 through the sample loading hole, and the plug 8 is covered. The test paper that will wait to detect the project loads in test paper recess 2, select the project that needs the detection, rotary sleeve 5, will go out the appearance hole and extend the hole intercommunication, move slider 4 up or down, make and extend hole and capillary 3 intercommunication, wait to detect the appearance and flow to capillary 3 in through the application of sample hole, again from capillary 3's mouth of pipe dropwise add to the test paper on, in order to wait to detect the outflow of appearance with higher speed, can press extrusion piston 7 downwards, wait to detect the outflow of appearance with higher speed, accomplish required detection, it is concrete, the appearance volume control of every turn of the mouth of pipe of every capillary 3 is at 80 ~ 100 microliters. Dropping the appearance and ending, removing slider 4, stopping up the extension hole, later rotating sleeve 5 blocks up out the appearance hole, can prevent to wait to examine the appearance and flow, and repeated operation can when examining next time, when need not continue to examine, take out application of sample section of thick bamboo 6, the washing can.
Claims (10)
1. The utility model provides an immunoassay box, includes at the bottom of the paper test tray box and adds a kind section of thick bamboo, its characterized in that: the sample adding cylinder is positioned at the center of the top of the test paper disc bottom box, a plurality of test paper grooves surrounding the sample adding cylinder are formed in the test paper disc bottom box, detection test paper is embedded in the test paper grooves, sample outlet holes opposite to the test paper grooves are formed in the cylinder wall of the sample adding cylinder, a plurality of sliding blocks blocking the sample outlet holes are arranged outside the sample outlet holes, the sliding blocks are connected with the cylinder wall of the sample adding cylinder in a sliding mode in the vertical direction, capillary tubes communicated with the sample outlet holes penetrate through the sliding blocks, and tube orifices at one end, far away from the sample outlet holes, of the capillary tubes are positioned right above the detection test paper.
2. An immunoassay cassette according to claim 1, wherein: and the inner wall of the sliding block is positioned above the capillary or below the capillary, and an elastic plug for blocking the sampling hole is arranged on the inner wall of the sliding block and is connected with the sliding block through a spring.
3. An immunoassay cassette according to claim 1 or 2, wherein: the capillary inclines towards one side of the detection test paper, and the inclination angle is 5-30 degrees.
4. An immunoassay cassette according to claim 3, wherein: the sample adding cylinder is detachably connected with the paper test disc bottom box, and a clamping groove for inserting or screwing the sample adding cylinder is formed in the center of the top of the paper test disc bottom box.
5. An immunoassay cassette according to claim 4, wherein: the bottom of adding a kind of section of thick bamboo is equipped with out the liquid hole, it is equipped with the end cap that is used for blockking up out the liquid hole to go out on the liquid hole, the bottom of adding a kind of section of thick bamboo is equipped with the inner groovy that is used for placing the end cap.
6. An immunoassay kit according to claim 5, wherein: the inner wall sliding connection of a sample adding cylinder has an extrusion piston, be equipped with the application of sample hole with an application of sample cylinder intercommunication on the extrusion piston, be equipped with the stopper on the application of sample hole.
7. An immunoassay cassette according to claim 2, wherein: the outside cover that adds a kind of section of thick bamboo is equipped with the sleeve, telescopic inner wall and the outer wall contact of a kind of sample section of thick bamboo, be equipped with on the sleeve with go out the extension hole of appearance hole coincidence, the slider sets up on telescopic outer wall, and with sleeve sliding connection, capillary and extension hole intercommunication.
8. An immunoassay cassette according to claim 7, wherein: the elastic plugs are arranged on the sleeve and located on the circle center connecting lines of the plurality of extension holes and used for blocking the sample outlet holes, and the elastic plugs are connected with the sleeve through springs.
9. An immunoassay cassette according to claim 6, wherein: and a cover is arranged at the upper part of the test paper tray bottom box.
10. An immunoassay cassette according to claim 8, wherein: the shape of the paper tray bottom box is round, square, diamond or regular polygon.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020924996.6U CN212159824U (en) | 2020-05-27 | 2020-05-27 | Immunoassay box |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020924996.6U CN212159824U (en) | 2020-05-27 | 2020-05-27 | Immunoassay box |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212159824U true CN212159824U (en) | 2020-12-15 |
Family
ID=73701414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202020924996.6U Expired - Fee Related CN212159824U (en) | 2020-05-27 | 2020-05-27 | Immunoassay box |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212159824U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406321A (en) * | 2021-06-17 | 2021-09-17 | 黄埔海关技术中心 | Multi-mycotoxin synchronous rapid detection robot and detection method |
-
2020
- 2020-05-27 CN CN202020924996.6U patent/CN212159824U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113406321A (en) * | 2021-06-17 | 2021-09-17 | 黄埔海关技术中心 | Multi-mycotoxin synchronous rapid detection robot and detection method |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20201215 |
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| CF01 | Termination of patent right due to non-payment of annual fee |