CN212118753U

CN212118753U - Photodynamic gel packaging dressing and male photodynamic gel packaging dressing device

Info

Publication number: CN212118753U
Application number: CN201921637876.1U
Authority: CN
Inventors: 赵志国; 丁克云; 代李兰
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-09-27
Filing date: 2019-09-27
Publication date: 2020-12-11
Anticipated expiration: 2029-09-27

Abstract

The utility model relates to a light power gel package dressing, including the outer and medicine dressing layer of package, the medicine dressing layer closely combines on the outer inboard surface of package, and the soft material of medicine dressing layer for having the infiltration nature, the in situ infiltration of medicine dressing has gel type photosensitizer. The utility model discloses still relate to male photodynamic gel package dressing device, including the elastic sleeve body, the inner wall of the elastic sleeve body is equipped with foretell photodynamic gel package dressing on the surface, and the outer outside fixed surface of package of photodynamic gel package dressing combines on the inner wall of the elastic sleeve body is surperficial. The photodynamic gel packaging dressing can be cut and designed into different shapes so as to be convenient for being matched with a part needing to be used, the operation is simple, and a patient can wear the photodynamic gel packaging dressing in an operable way. When the male photodynamic gel packaging dressing device is used, the elastic sleeve body is sleeved on the penis, the medicine dressing layer is directly contacted and attached with the penis, and ALA medicines in the medicine dressing layer can well permeate into the deep layer of the pathological tissue to play a role.

Description

Photodynamic gel packaging dressing and male photodynamic gel packaging dressing device

Technical Field

The invention relates to a photodynamic gel packaging dressing and a photodynamic gel packaging dressing device for men.

Background

The special drug injected into the blood or applied to the skin is called a photosensitizer, and when the photosensitizer is absorbed by the cancer cells, by applying "light" to the treated area, the drug can form a chemical substance with oxygen that can kill the cancer cells (or cells infected by HPV) and can cut off the nutrient supply of the cancer cells or cells infected by HPV. Compared with the traditional tumor therapy, the photodynamic therapy has the advantages of no wound, no damage, real-time dynamic, accurate treatment and low side effect. Three photosensitizing drugs have been approved by the U.S. Food and Drug Administration (FDA), namely PHOTOFRIN (common name), Visudyne (common name verteporfin, or BPD-MA for short in chemical structure), and aminolevulinic acid (ALA). The latter two are mainly used for the treatment of non-neoplastic diseases (senile fundus macular degeneration, photochemical keratosis). To date, PHOTOFRIN is the only photosensitive drug that has been approved by the U.S. FDA for use in the treatment of a variety of solid malignancies. It is a mixture of porphyrin oligomers extracted from bovine blood and chemically modified, which has been approved by government drug administration in more than ten countries such as the United states, Canada, France, the Netherlands, Germany, UK, Japan, Korea, etc., and can be used for the conventional treatment of some types of tumor patients among esophageal cancer, lung cancer, bladder cancer, cervical cancer and skin cancer, respectively.

In the prior art, domestic ALAs (ALA) medicines are exclusively developed and produced by shanghai fudan zhangjiang biomedicine limited company. The main operation steps of the photodynamic therapy process are dressing and irradiation. Medical care personnel prepares fresh liquid medicine, and applies the fresh liquid medicine to the affected part for 3 to 6 hours in a wet way, and packages the liquid medicine according to specific conditions. During the period, the patient can do proper free movement under the condition of ensuring that the gauze or cotton ball for applying the medicine does not move. After the application of the medicine is finished, the focal part is irradiated by the photodynamic light, and the irradiation time is usually 20 minutes per light spot. After the treatment course is finished, the wart body comes home and is observed, and becomes sheet-shaped, dried and falls off automatically. ALA medicine is white to faint yellow powder, and when in use, an operator needs to dilute the powder with normal saline to a certain concentration, then the powder is soaked and wet-applied to an affected part by using a cotton ball, and the affected part is externally wrapped by a plastic film, so that the medicine is permeated into a pathological change tissue and is combined with the pathological change tissue to perform operation.

However, the product has the following defects in clinical treatment:

1) the product is a powdered water-soluble solvent, and has poor permeability: the law of osmotic absorption of chemical substances in the skin is: the oily and water-soluble substances are most easily absorbed, the fat-soluble substances are the second, and the water-soluble substances are most difficult to absorb, so the product has low absorption utilization rate and poor permeability.

2) The product has poor stability: because the ALA medicament and the solvent (water or gel) are separated, the ALA medicament and the solvent need to be mixed before use, and the whole process needs to be protected from light; and also, the food should be kept cold during preservation, which is inconvenient. In addition, because ALA drug is decomposed after mixing, the ALA drug must be used in a short time (4 hours), and the residual drug amount cannot be preserved for use.

3) And poor treatment concentration control: because the ALA medicine and the solvent are separated, workers are required to mix before use, the operation of different workers has individual difference, the mixing time and the dissolution degree of the medicine powder are different, and some or even half of the powder gel can not be dissolved, so that the medicine waste is caused, the utilization rate is low, the treatment effect of a patient is poor, the relapse and treatment frequency are increased, and the treatment cost is doubled.

4) Complex operation, long operation time and large difference: the whole process needs to go through the steps of chemical medicine soaking, cotton soaking, packaging, fixing, light shielding and the like, and the final curative effect is influenced when each step is not operated in place. If the plastic film is not sealed well, the absorbent cotton can slide and fall off, and the treatment effect can not be achieved; the uneven thickness and different areas of the soaked cotton can cause uneven medicine infiltration of pathological tissues, the problems of more infiltration in some places and no infiltration in some places occur, and the treatment effect is seriously influenced; the fixation is difficult, and the strip adhesive tapes are bound and fixed in a quincuncial large binding mode.

5) The price is high, the use area is small: a medicinal powder of 118mg is 863 Yuan ren Min Bing, which is more expensive than gold diamond, and ALA medicine of 118mg can be used for focus with diameter of 2 cm.

6) The clinically used solvents (water for injection, matrix cream and heat-sensitive adhesive) and external application materials (cotton, facial tissue and cosmetic cotton) are not uniform, and have no fixed treatment standard, so that the treatment effect is quite different, and the clinical effect observation and research are not facilitated.

Korean patent application No. 1020090072790 discloses a gel type photosensitizer (RGALA), which is a cosmetic composition containing ALA (5-aminolevulinic acid) to treat acne with high stability of active ingredients and to preserve and relieve skin discomfort. The cosmetic composition comprises 1-20% of 5-aminolevulinic acid, 0.1-30% of purified water, 0.001-20% of ginsenoside extract RG2, 1-60% of propylene glycol, and 0.1-30% of ethanol. The cosmetic ingredient is used in the form of an emulsion, a milky lotion or a cream. The cosmetic composition contains components other than 5-aminolevulinic acid, and can be used as stabilizer for long-term storage of photosensitive medicine.

Disclosure of Invention

The invention aims to overcome the defects in the prior art and provides a photodynamic gel packaging dressing and a male photodynamic gel packaging dressing device, which have the advantages of ingenious structure, reasonable design, convenience in use and wide application.

The first purpose of the invention is realized by the following technical scheme:

the photodynamic gel packaging dressing is characterized in that: the medical dressing layer is tightly combined on the inner side surface of the outer package layer, the medical dressing layer is made of a wetting soft material, and a gel type photosensitizer is wetted in the medical dressing layer.

As a further improvement of the photodynamic gel package dressing, the outer layer of the package is a soft rubber film, a silica gel film, a polyurethane film, a polylactic acid film, a polyethylene film or a polypropylene ethylene film.

As a further improvement of the photodynamic gel packaging dressing, an adhesive layer is arranged on the outer side surface of the packaging outer layer.

As a further improvement of the photodynamic gel packaging dressing, the medicine dressing layer is made of silk fabric, non-woven fabric, cosmetic cotton, pure cotton fabric, biological fiber fabric, chemical fiber fabric, chitosan fabric or blended fabric with uniform thickness.

As a further improvement of the photodynamic gel encapsulation dressing, the gel-type photosensitizer contains 10-25 wt% of ALA photosensitizer, ALA methyl ester photosensitizer, metal phenol cyanine photosensitizer or condensed ring quinone photosensitizer.

As a further improvement of the dressing, the gel type photosensitizer further comprises purified water, ginsenoside extract RG2, hydrogenated castor oil, xanthan gum, kaolin, a humectant and a local anesthetic; the humectant is any one or free combination of any more of propylene glycol, ethanol and butanediol; the local anesthetic is lidocaine or procaine or bupivacaine.

The second purpose of the invention is realized by the following technical scheme:

male photodynamic gel package dressing device which characterized in that: the front wrapping part, the rear constraint fixing part and the middle connecting part are all made of flexible waterproof materials; the front wrapping portion is used for wrapping the penis, an applying block is pasted on the inner surface of the front wrapping portion and formed by cutting the photodynamic gel packaging dressing, a fixing and pasting layer is arranged on the area, located on the periphery of the applying block, of the inner surface of the front wrapping portion, and a fixing and pasting layer is also arranged on the inner surface of the rear restraint fixing portion and the inner surface of the middle connecting portion.

The second object of the present invention can also be achieved by the following technical solutions:

male photodynamic gel package dressing device which characterized in that: the photodynamic gel packaging dressing is characterized by comprising an elastic sleeve body, wherein the elastic sleeve body is used for being sleeved on a penis, the inner wall surface of the elastic sleeve body is provided with the photodynamic gel packaging dressing, and the outer side surface of the packaging layer of the photodynamic gel packaging dressing is fixedly combined on the inner wall surface of the elastic sleeve body.

As a further improvement of the male photodynamic gel packaging dressing device, the rear end of the elastic sleeve body is provided with a fixed adhesive sticker, the fixed adhesive sticker is used for being pasted on the skin around the root of the penis, and the fixed adhesive sticker and the elastic sleeve body are integrally arranged.

As a further improvement of the male photodynamic gel packaging dressing device, the rear end of the elastic sleeve body is provided with an elastic tightening belt which is used for being sleeved on the penis and the scrotum; the elastic sleeve body is made of rubber or silica gel.

Compared with the prior art, the invention has the following advantages:

1) the photodynamic gel packaging dressing can be cut into different shapes, so that the dressing can be conveniently matched with a part needing to be used, the operation is simple, a patient can wear the dressing in an operable manner, and 1/4 can be shortened to 1/4 when the dressing is operated by a common product.

2) The outer layer of the package in the photodynamic gel package dressing is a soft high-molecular elastomer film which can be properly stretched to ensure that the treatment area is completely covered, wherein the polyurethane film has elasticity and air permeability, so that the patient feels very comfortable when using the photodynamic gel package dressing; the medicine dressing layer is silk fabric, non-woven fabric, cosmetic cotton, pure cotton fabric, biological fiber fabric, chemical fiber fabric, chitosan fabric or blended fabric with uniform thickness, wherein the silk fabric is not only skin-friendly and non-irritant, but also can completely soak photosensitizer, and can well solve the problem of uneven medicine dressing concentration parts and the like.

3) The thickness of the photodynamic gel packaging dressing layer is uniform, the distribution of the surface photosensitive medicine is uniform, the medicine can be uniformly infiltrated into the interior of the pathological change tissue of the treated part, and the photodynamic gel packaging dressing layer is selectively used for the focus, thereby exerting the effect of removing the focus to the maximum extent.

4) The male photodynamic gel packaging dressing device comprises a front wrapping part, a rear constraint fixing part and a middle connecting part which are integrally connected, wherein the front wrapping part is wrapped on the penis (mainly glans and coronary sulcus) when in use, the wrapping and fixing form is convenient to operate, and the male photodynamic gel packaging dressing device can be suitable for the penis with different sizes, so that a medicine dressing layer on a dressing block can be tightly attached to the surface of the penis, and ALA medicines in the medicine dressing layer can well permeate into the deep layer of a lesion tissue to play a role; and then the whole photodynamic gel packaging dressing device can be kept stable by restricting the fixing part, so that the treatment effect is improved.

5) The male photodynamic gel package dressing device comprises an elastic sleeve body, wherein photodynamic gel package dressing is arranged on the surface of the inner wall of the elastic sleeve body, the elastic sleeve body is used for being sleeved on a penis during use, so that a medicine dressing layer is directly contacted and attached with the penis of a patient, and ALA medicines in the medicine dressing layer can well permeate into the deep layer of a pathological change tissue to play a role.

6) The photodynamic gel packaging dressing device is characterized in that the rear end of the elastic sleeve body is provided with the fixed adhesive tape and/or the elastic contraction band, so that the elastic sleeve body is more convenient and reliable to fix.

Drawings

Fig. 1 is a schematic view of the overall structure of a layer in embodiment 1 of the present invention.

Fig. 2 is a schematic view of an appearance structure of embodiment 2 of the present invention.

Fig. 3 is a schematic structural diagram of the appearance of embodiment 3 of the present invention.

Fig. 4 is a structural sectional view of embodiment 3 of the present invention.

Fig. 5 is a schematic view showing a shape of a mask used for a face.

Description of reference numerals: 1-outer wrapping layer, 2-medicine dressing layer, 3-sticking layer, 4-front wrapping part, 5-rear constraint fixing part, 6-middle connecting part, 7-dressing block, 8-elastic sleeve body and 9-fixing adhesive plaster.

Detailed Description

The invention is further illustrated by the following specific figures and examples.

Example 1

As shown in fig. 1, embodiment 1 discloses a photodynamic gel envelope dressing, which comprises an envelope outer layer 1 and a drug dressing layer 2, wherein the drug dressing layer 2 is tightly bonded on the inner side surface of the envelope outer layer 1, the drug dressing layer 2 is a soft material with wettability, and a gel type photosensitizer is soaked in the drug dressing layer 2.

During specific use, the photodynamic gel packaging dressing can be cut into different shapes according to different use parts of a human body, so that the photodynamic gel packaging dressing can be conveniently matched with the use parts required, is simple to operate, can be worn by a patient in an operable manner, and can be shortened to 1/4 used for operating a common product during operation.

In this embodiment 1, the outer layer 1 of the package is a soft rubber film, a silicone film, a polyurethane film, a polylactic acid film, a polyethylene film, a polypropylene film, a soft rubber film, a latex film, a silicone film, a polyurethane film, or other high molecular elastomer films, which can be properly stretched to cover the treatment area, wherein the polyurethane film has both elasticity and air permeability, and is very comfortable for the patient to use. The outer surface of the outer packaging layer 1 is provided with an adhesive layer 3, so that the photodynamic gel packaging dressing can be conveniently fixed on some carriers, and the material of the adhesive layer 3 can be the adhesive layer material on the existing medical application.

In this embodiment 1, the drug dressing layer 2 is made of silk fabric, non-woven fabric, cosmetic cotton, pure cotton fabric, bio-fiber fabric, chemical fiber fabric, chitosan fabric or blended fabric with uniform thickness. Preferably, the silk fabric is adopted, is skin-friendly and non-irritant, can completely soak the photosensitizer, and can well solve the problem of uneven medicine application concentration parts and the like.

In example 1, the gel-type photosensitizer contains 10 to 25% by weight of an ALA photosensitizer, an ALA methyl ester photosensitizer, a metal phthalocyanine photosensitizer or a fused ring quinone photosensitizer. In practical application, different concentrations can be selected according to different lesion property parts of a patient, and targeted treatment is performed. The concentration can be freely adjusted according to the state of the patient in the treatment process, so that the satisfaction of the patient is maximized, the recurrence is reduced, and the times of repeated treatment are reduced. In addition, the gel type photosensitizer further comprises purified water, ginsenoside extract RG2, hydrogenated castor oil, xanthan gum, kaolin, a humectant and a local anesthetic; the humectant is any one or free combination of any more of propylene glycol, ethanol and butanediol; the local anesthetic is lidocaine or procaine or bupivacaine, and the dosage of the local anesthetic is preferably 0.5-2% by weight. Among the above components, the purified water is used as a solvent, the ginsenoside extract RG2 is used as an antioxidant, propylene glycol, ethanol and butylene glycol are used as an antibacterial agent and a solvent in addition to a humectant, the hydrogenated castor oil is used as a surfactant, an emulsifier and a solvent, the xanthan gum is used as a thickener and an emulsion stabilizer, and the kaolin is used as an adsorbent and a filler.

In the present invention, the gel type photosensitizer [ RGALA ] in the drug coating layer 2 was developed by using the technology of the korean advanced chemical company [ GLONM ], and the photosensitizer ALA can be kept stable for a long period of time, so that it can be used without being mixed with a solvent before use, and it can be used directly without refrigeration, and there is no limitation on the operation environment, and it can be used without dark room, and the remaining amount of drug can be stored for a long time and reused. The gel type photosensitizer (RGALA) is an oily and water-soluble substance, is most easily absorbed by skin, has excellent permeability, can well permeate deep layer of lesion tissues to play the maximum photodynamic effect, and shortens the application time (2 hours) to half of that of the existing product. Compared with the prior usage, the ALA medicament is uniformly distributed in the medicament dressing layer 2, and the usage area is large. One 118mg ALA medicine can act on the focus of 12 square centimeters, and the price of the unit area dosage is only 1/6 of the price of the existing product.

Example 2

As shown in fig. 2, embodiment 2 discloses a photovoltaic gel pack dressing device for men, which comprises a front wrapping part 4, a rear constraint fixing part 5 and an intermediate connecting part 6 which are integrally connected, wherein the front wrapping part 4, the rear constraint fixing part 5 and the intermediate connecting part 6 are all made of flexible waterproof materials; the front wrapping portion 4 is used for wrapping the penis, an applying block 7 is pasted on the inner surface of the front wrapping portion 4, the applying block 7 is formed by cutting the photodynamic gel packet dressing according to any one of claims 1 to 5, a fixing and pasting layer is arranged on the inner surface of the front wrapping portion 4 at the periphery of the applying block 7, and a fixing and pasting layer is also arranged on the inner surfaces of the rear constraint fixing portion 5 and the middle connecting portion 6.

When the penis fixing device is used specifically, the front wrapping part 4 is wrapped on the penis of a patient and is connected in an adhesive mode through the fixing and pasting layer, and then the rear restraint fixing part 6 is wound at the root of the scrotum of the patient and is connected in an adhesive mode through the fixing and pasting layer. The wrapping and fixing mode is convenient to operate, and can be suitable for the penis with different sizes, so that the medicine dressing layer 2 on the dressing block 7 is ensured to be directly contacted and attached with the penis of a patient, and ALA medicine in the medicine dressing layer 2 can well permeate into the deep layer of a pathological tissue to play a role; and then the restraint fixing part 6 can ensure that the whole photodynamic gel packaging dressing device keeps stable, thereby improving the treatment effect.

In this embodiment 2, the flexible waterproof material may be a conventional product in the prior art, such as a medical waterproof film commonly used at present.

Example 3

As shown in fig. 3 and 4, embodiment 3 discloses a device for applying a photodynamic gel encapsulation dressing for men, which comprises an elastic sleeve body 8, wherein the elastic sleeve body 8 is used for being sleeved on a penis, the photodynamic gel encapsulation dressing is arranged on the inner wall surface of the elastic sleeve body 8, and the outer side surface of an encapsulation outer layer 1 of the photodynamic gel encapsulation dressing is fixedly combined on the inner wall surface of the elastic sleeve body 8.

When the medical dressing layer is used specifically, the elastic sleeve body 8 is directly sleeved on the penis of a patient, so that the medical dressing layer 2 is directly contacted and attached with the penis of the patient, and ALA medicines in the medical dressing layer 2 can well permeate into the deep layer of a pathological tissue to play a role.

As shown in fig. 3 and 4, in this embodiment 2, the back end of the elastic sleeve body 8 is provided with a fixing sticker 9, the fixing sticker 9 is used for being stuck on the skin around the root of the penis, and the fixing sticker 9 is integrally provided with the elastic sleeve body 8. So set up for elastic sleeve body 8 is fixed more convenient reliable.

In addition, the rear end of the elastic sleeve body 8 can be provided with an elastic tightening band (not shown in the figure) which is sleeved on the penis and the scrotum. So set up, elasticity is taken in the area and also can be played supplementary fixed action, is suitable for the inconvenient patient who pastes fixed sticker 9 and uses. In this embodiment 2, the elastic sleeve 8 is preferably made of rubber or silicone.

It should be noted that the photodynamic gel sealing dressing can be used on other parts of the human body besides the penis, and at this time, the photodynamic gel sealing dressing needs to be cut and designed into a corresponding shape according to different using parts of the human body. Fig. 5 shows a shape of a mask used for a face.

The above description is only for the preferred embodiment of the present invention, and the above specific embodiments are not intended to limit the present invention. Various modifications and alterations may occur to those skilled in the art without departing from the spirit and scope of the invention, and such modifications and alterations should be accorded the broadest interpretation so as to encompass all such modifications and alterations.

Claims

1. The photodynamic gel packaging dressing is characterized in that: the patch is characterized by comprising a package outer layer (1) and a medicine dressing layer (2), wherein the medicine dressing layer (2) is tightly combined on the inner side surface of the package outer layer (1), the medicine dressing layer (2) is made of a soft material with wettability, and a gel type photosensitizer is soaked in the medicine dressing layer (2).

2. The photodynamic gel encapsulation dressing of claim 1, wherein: the outer layer (1) of the package is a soft rubber film, a latex film, a silica gel film or a polyurethane film.

3. The photodynamic gel encapsulation dressing of claim 1, wherein: and an adhesive layer (3) is arranged on the outer surface of the outer packaging layer (1).

4. The photodynamic gel encapsulation dressing of claim 1, wherein: the drug dressing layer (2) is a silk fabric, a non-woven fabric, a cosmetic cotton, a pure cotton fabric, a biological fiber fabric, a chemical fiber fabric, a chitosan fabric or a blended fabric with uniform thickness.

5. Male photodynamic gel package dressing device which characterized in that: the front wrapping part (4), the rear constraint fixing part (5) and the middle connecting part (6) are integrally connected, and the front wrapping part (4), the rear constraint fixing part (5) and the middle connecting part (6) are all made of flexible waterproof materials; the front wrapping portion (4) is used for wrapping the penis, an applying block (7) is pasted on the inner surface of the front wrapping portion (4), the applying block (7) is formed by cutting the photodynamic gel packaging dressing according to any one of claims 1 to 4, a fixing and pasting layer is arranged on the area, located on the periphery of the applying block (7), of the inner surface of the front wrapping portion (4), and a fixing and pasting layer is also arranged on the inner surfaces of the rear constraint fixing portion (5) and the middle connecting portion (6).

6. The male photodynamic gel encapsulated dressing device of claim 5, wherein: the photodynamic gel sealing dressing comprises an elastic sleeve body (8), wherein the elastic sleeve body (8) is used for being sleeved on a penis, the inner wall surface of the elastic sleeve body (8) is provided with the photodynamic gel sealing dressing as claimed in any one of claims 1 to 4, and the outer side surface of the sealing outer layer (1) of the photodynamic gel sealing dressing is fixedly combined on the inner wall surface of the elastic sleeve body (8).

7. The male photodynamic gel encapsulated dressing device of claim 6, wherein: the rear end of the elastic sleeve body (8) is provided with a fixed adhesive sticker (9), the fixed adhesive sticker (9) is used for being pasted on the skin around the root of the penis, and the fixed adhesive sticker (9) and the elastic sleeve body (8) are integrally arranged.

8. The male photodynamic gel encapsulated dressing device of claim 6, wherein: the rear end of the elastic sleeve body (8) is provided with an elastic tightening belt which is used for being sleeved on the penis and the scrotum; the elastic sleeve body (8) is made of rubber or silica gel.