CN211751739U - Female photodynamic gel packaging dressing device - Google Patents
Female photodynamic gel packaging dressing device Download PDFInfo
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- CN211751739U CN211751739U CN201921639630.8U CN201921639630U CN211751739U CN 211751739 U CN211751739 U CN 211751739U CN 201921639630 U CN201921639630 U CN 201921639630U CN 211751739 U CN211751739 U CN 211751739U
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Abstract
The utility model relates to a female photodynamic gel packaging dressing device, which comprises an elastic cylinder body and an elastic cervical cap, wherein the elastic cylinder body is used for being implanted into a vagina, the elastic cervical cap is arranged at the front end of the elastic cylinder body, the elastic cervical cap is used for covering and sleeving a cervix, the elastic cervical cap is integrally in a bowl shape, and a small bulge is arranged at the center position of the bottom of the bowl of the elastic cervical cap, so that the shape of the inner cavity of the elastic cervical cap is matched with the shape of the cervix; the outer wall surface of the elastic column body and the inner and outer wall surfaces of the elastic cervical cap are both provided with a medicine dressing layer, the medicine dressing layer is made of a wetting soft material, and a gel type photosensitizer is wetted in the medicine dressing layer. When the photodynamic gel packaging dressing device for the female is used, the device is inserted into a vagina, after the device is inserted in place, the elastic cervical cap is sleeved at the cervix, at the moment, the medicine dressing layer is tightly contacted and attached with the cervix and the vagina, and ALA medicines in the medicine dressing layer can well permeate into the deep layer of a pathological change tissue to play a role.
Description
Technical Field
The utility model relates to a female photodynamic gel package dressing device belongs to medical instrument design technical field.
Background
The special drug injected into the blood or applied to the skin is called a photosensitizer, and when the photosensitizer is absorbed by the cancer cells, by applying "light" to the treated area, the drug can form a chemical substance with oxygen that can kill the cancer cells (or cells infected by HPV) and can cut off the nutrient supply of the cancer cells or cells infected by HPV. Compared with the traditional tumor therapy, the photodynamic therapy has the advantages of no wound, no damage, real-time dynamic, accurate treatment and low side effect. Three photosensitizing drugs have been approved by the U.S. Food and Drug Administration (FDA), namely PHOTOFRIN (common name), Visudyne (common name verteporfin, or BPD-MA for short in chemical structure), and aminolevulinic acid (ALA). The latter two are mainly used for the treatment of non-neoplastic diseases (senile fundus macular degeneration, photochemical keratosis). So far as the method for preparing the high-purity sodium silicate,
is the only photosensitive drug that has been approved by the FDA in the united states for use in the treatment of a variety of solid malignancies. It is a mixture of porphyrin oligomers extracted from bovine blood and chemically modified, which has been approved by government drug administration in more than ten countries such as the United states, Canada, France, the Netherlands, Germany, UK, Japan, Korea, etc., and can be used for the conventional treatment of some types of tumor patients among esophageal cancer, lung cancer, bladder cancer, cervical cancer and skin cancer, respectively.
In the prior art, domestic ALAs (ALA) medicines are exclusively developed and produced by shanghai fudan zhangjiang biomedicine limited company. The main operation steps of the photodynamic therapy process are dressing and irradiation. Medical care personnel prepares fresh liquid medicine, and applies the fresh liquid medicine to the affected part for 3 to 6 hours in a wet way, and packages the liquid medicine according to specific conditions. During the period, the patient can do proper free movement under the condition of ensuring that the gauze or cotton ball for applying the medicine does not move. After the application of the medicine is finished, the focal part is irradiated by the photodynamic light, and the irradiation time is usually 20 minutes per light spot. After the treatment course is finished, the wart body comes home and is observed, and becomes sheet-shaped, dried and falls off automatically. ALA medicine is white to faint yellow powder, and when in use, an operator needs to dilute the powder with normal saline to a certain concentration, then the powder is soaked and wet-applied to an affected part by using a cotton ball, and the affected part is externally wrapped by a plastic film, so that the medicine is permeated into a pathological change tissue and is combined with the pathological change tissue to perform operation.
However, the product has the following defects in clinical treatment:
1) the product is a powdered water-soluble solvent, and has poor permeability: the law of osmotic absorption of chemical substances in the skin is: the oily and water-soluble substances are most easily absorbed, the fat-soluble substances are the second, and the water-soluble substances are most difficult to absorb, so the product has low absorption utilization rate and poor permeability.
2) The product has poor stability: because the ALA medicament and the solvent (water or gel) are separated, the ALA medicament and the solvent need to be mixed before use, and the whole process needs to be protected from light; and also, the food should be kept cold during preservation, which is inconvenient. In addition, because ALA drug is decomposed after mixing, the ALA drug must be used in a short time (4 hours), and the residual drug amount cannot be preserved for use.
3) And poor treatment concentration control: because the ALA medicine and the solvent are separated, workers are required to mix before use, the operation of different workers has individual difference, the mixing time and the dissolution degree of the medicine powder are different, and some or even half of the powder gel can not be dissolved, so that the medicine waste is caused, the utilization rate is low, the treatment effect of a patient is poor, the relapse and treatment frequency are increased, and the treatment cost is doubled.
4) Complex operation, long operation time and large difference: the whole process needs to go through the steps of chemical medicine soaking, cotton soaking, packaging, fixing, light shielding and the like, and the final curative effect is influenced when each step is not operated in place. If the plastic film is not sealed well, the absorbent cotton can slide and fall off, and the treatment effect can not be achieved; the uneven thickness and different areas of the soaked cotton can cause uneven medicine infiltration of pathological tissues, the problems of more infiltration in some places and no infiltration in some places occur, and the treatment effect is seriously influenced; the fixation is difficult, and the strip adhesive tapes are bound and fixed in a quincuncial large binding mode.
5) The price is high, the use area is small: a medicinal powder of 118mg is 863 Yuan ren Min Bing, which is more expensive than gold diamond, and ALA medicine of 118mg can be used for focus with diameter of 2 cm.
6) The clinically used solvents (water for injection, matrix cream and heat-sensitive adhesive) and external application materials (cotton, facial tissue and cosmetic cotton) are not uniform, and have no fixed treatment standard, so that the treatment effect is quite different, and the clinical effect observation and research are not facilitated.
Korean patent application No. 1020090072790 discloses a gel type photosensitizer (RGALA), which is a cosmetic composition containing ALA (5-aminolevulinic acid), to treat acne with high stability of active ingredients and to preserve and alleviate skin discomfort. The cosmetic composition comprises 1-20% of 5-aminolevulinic acid, 0.1-30% of purified water, 0.001-20% of ginsenoside extract RG2, 1-60% of propylene glycol, and 0.1-30% of ethanol. The cosmetic ingredient is used in the form of an emulsion, a milky lotion or a cream. The cosmetic composition contains components other than 5-aminolevulinic acid, and can be used as stabilizer for long-term storage of photosensitive medicine.
Disclosure of Invention
The utility model aims to overcome the defects in the prior art and provide a female photodynamic gel packaging dressing device with ingenious structure, reasonable design and convenient use.
According to the utility model provides a technical scheme: female photodynamic gel package dressing device, its characterized in that: the cervical protection device comprises an elastic cylinder body and an elastic cervical cap, wherein the elastic cylinder body is implanted into a vagina, the elastic cervical cap is arranged at the front end of the elastic cylinder body and used for covering the cervix, the elastic cervical cap is integrally bowl-shaped, and a small bulge is arranged at the center of the bottom of the bowl of the elastic cervical cap, so that the shape of the inner cavity of the elastic cervical cap is matched with the shape of the cervix; the outer wall surface of the elastic column body and the inner and outer wall surfaces of the elastic cervical cap are both provided with a medicine dressing layer, the medicine dressing layer is made of a wetting soft material, and a gel type photosensitizer is wetted in the medicine dressing layer.
As a further improvement of the utility model, the rear end of the elastic column body is provided with a fixed glue sticker which is used for being pasted on the skin around the private parts.
As a further improvement of the utility model, the fixed glue paste and the elastic column body are integrally arranged.
As a further improvement of the utility model, the drug dressing layer is made of silk fabric, non-woven fabric, cosmetic cotton, pure cotton fabric, biological fiber fabric, chemical fiber fabric, chitosan fabric or blended fabric with uniform thickness; the outer layer of the package is a soft rubber film, a latex film, a silica gel film or a polyurethane film.
As a further improvement of the utility model, the gel-type photosensitizer contains 10-25 wt% of ALA photosensitizer, ALA methyl ester photosensitizer, metal phenol cyanine photosensitizer or condensed ring quinone photosensitizer.
As a further improvement of the present invention, the gel-type photosensitizer further comprises purified water, ginsenoside extract RG2, hydrogenated castor oil, xanthan gum, kaolin, a humectant and a local anesthetic; the humectant is any one or free combination of any more of propylene glycol, ethanol and butanediol; the local anesthetic is lidocaine or procaine or bupivacaine.
As a further improvement of the utility model, the medicine dressing layer is fixed to be combined with the outer layer of a package on the surface, the outer another of package is equipped with on the surface and pastes the layer, paste the layer and paste on the outer wall surface of elasticity cylinder and the inner chamber of elasticity cervical cage on the surface.
As a further improvement of the utility model, the elastic column body is detachably connected with the elastic cervical shield.
As a further improvement of the utility model, the nut has been buried underground to the inside trompil of elasticity cylinder front end, the double-screw bolt has been buried underground to the bottom of elasticity cervical cage, threaded connection between elasticity cylinder and the elasticity cervical cage.
As a further improvement of the utility model, the elastic cylinder and the elastic cervical cap are made of rubber or silica gel.
Compared with the prior art, the utility model, have following advantage:
1) when the photodynamic gel packaging dressing device for the female is used, the device is inserted into a vagina, after the device is inserted in place, the elastic cervical cap is sleeved at the cervix, at the moment, the medicine dressing layer is tightly contacted and attached with the cervix and the vagina, and ALA medicines in the medicine dressing layer can well permeate into the deep layer of a pathological change tissue to play a role. The whole operation process is very simple, the patient can wear the device by himself, and the operation time can be shortened to 1/4 of the operation time of a common product.
2) This female photodynamic gel package dressing device sets up fixed gluing at the rear end of elastic column body and pastes for elastic column body is fixed more convenient and reliable.
3) This female light power gel package dressing device, for can dismantling the connection between elastic cylinder body and the elasticity cervical cage, to the patient that some cervical parts in clinical need not to use medicine, just can take off elasticity cervical cage, avoid extravagant.
4) This female photodynamic gel package dressing device, medicine dressing layer thickness is even unanimous, and surperficial photosensitive medicine distributes evenly, can make medicine even soak to by inside the pathological change tissue of treatment position, furthest's play removes the effect of focus.
5) This female light power gel package dressing device can closely laminate with women's vagina and cervix uteri, is difficult to the slippage to can guarantee that ALA medicine in the medicine dressing layer just can be fine permeate to the pathological change tissue deep level, play a role.
Drawings
Fig. 1 is a schematic structural diagram of embodiment 1 of the present invention.
Fig. 2 is a schematic structural diagram of embodiment 2 of the present invention.
Description of reference numerals: 1-elastic column, 2-elastic cervical cap, 3-small bulge, 4-medicine dressing layer, 5-fixed glue, 6-outer layer of package, 7-nut and 8-stud.
Detailed Description
The invention is further described with reference to the following specific drawings and examples.
Example 1
As shown in fig. 1, embodiment 1 discloses a female photodynamic gel encapsulation dressing device, which comprises an elastic cylinder 1 and an elastic cervical cap 2, wherein the elastic cylinder 1 is used for being implanted into a vagina, the elastic cervical cap 2 is installed at the front end of the elastic cylinder 1, the elastic cervical cap 2 is used for covering and sleeving a cervix, the elastic cervical cap 2 is integrally bowl-shaped, and a small bulge 3 is arranged at the center of the bottom of the elastic cervical cap 2, so that the shape of an inner cavity of the elastic cervical cap 2 is matched with the shape of the cervix; the outer wall surface of the elastic column body 1 and the inner and outer wall surfaces of the elastic cervical cap 2 are both provided with a medicine dressing layer 4, the medicine dressing layer 4 is a soft material with wettability, and the medicine dressing layer 4 is infiltrated with a gel type photosensitizer.
When the medical cervical cap is used specifically, a female patient inserts the elastic cylinder 1 with the medicine dressing layer 4 into the vagina, after the elastic cylinder is inserted in place, the elastic cervical cap 2 is covered and sleeved on the cervix, at the moment, the medicine dressing layer 4 is tightly contacted and attached with the cervix and the vagina, and ALA medicines in the medicine dressing layer 4 can well permeate into the deep layer of a pathological change tissue to play a role. The whole operation process is very simple, the patient can wear the device by himself, and the operation time can be shortened to 1/4 of the operation time of a common product.
As shown in fig. 1, in this embodiment 1, a fixing adhesive tape 5 is disposed at a rear end of the elastic cylinder 1, and the fixing adhesive tape 5 is used for being attached to skin around the external genitalia. So set up for elastic column 1 is fixed more convenient reliable. Preferably, the fixing sticker 5 is integrally arranged with the elastic column body 1.
In the invention, the medicine dressing layer 4 is silk fabric, non-woven fabric, cosmetic cotton or flattened cotton with uniform thickness. Preferably, the silk fabric is adopted, is skin-friendly and non-irritant, can completely soak the photosensitizer, and can well solve the problem of uneven medicine application concentration parts and the like.
In this embodiment 1, the material of the elastic cylinder 1 and the elastic cervical cap 2 is preferably rubber or silicone. So set up, the patient uses the sense of touch good, and the comfort level is high.
In example 1, the gel-type photosensitizer contains 10 to 25% by weight of an ALA photosensitizer, an ALA methyl ester photosensitizer, a metal phthalocyanine photosensitizer or a fused ring quinone photosensitizer. In practical application, different concentrations can be selected according to different lesion property parts of a patient, and targeted treatment is performed. The concentration can be freely adjusted according to the state of the patient in the treatment process, so that the satisfaction of the patient is maximized, the recurrence is reduced, and the times of repeated treatment are reduced. In addition, the gel type photosensitizer further comprises purified water, ginsenoside extract RG2, hydrogenated castor oil, xanthan gum, kaolin, a humectant and a local anesthetic; the humectant is any one or free combination of any more of propylene glycol, ethanol and butanediol; the local anesthetic is lidocaine or procaine or bupivacaine, and the dosage of the local anesthetic is preferably 0.5-2% by weight. Among the above components, the purified water is used as a solvent, the ginsenoside extract RG2 is used as an antioxidant, propylene glycol, ethanol and butylene glycol are used as an antibacterial agent and a solvent in addition to a humectant, the hydrogenated castor oil is used as a surfactant, an emulsifier and a solvent, the xanthan gum is used as a thickener and an emulsion stabilizer, and the kaolin is used as an adsorbent and a filler.
The gel type photosensitizer [ RGALA ] in the drug coating layer 4 was developed by using the technology of korea advanced chemical company [ GLONM ], wherein the photosensitizer ALA can be kept stable for a long period of time, so that it is not necessary to mix with a solvent before use, and can be used directly, and it is not necessary to store it in a refrigerator, and there is no limitation on the operation environment, and it can be used in a dark room, and the remaining amount of drug can be stored for a long period of time for reuse. The gel type photosensitizer (RGALA) is an oily and water-soluble substance, is most easily absorbed by skin, has excellent permeability, can well permeate deep layer of lesion tissues to play the maximum photodynamic effect, and shortens the application time (2 hours) to half of that of the existing product. Compared with the prior usage, the ALA medicament is uniformly distributed in the medicament dressing layer 4, and the usage area is large. One 118mg ALA medicine can act on the focus of 12 square centimeters, and the price of the unit area dosage is only 1/6 of the price of the existing product.
Example 2
As shown in fig. 2, example 2 discloses a device for packaging and applying a female photodynamic gel, which is different from example 1 in that: the medicine dressing layer 4 in the embodiment 2 is fixedly combined on the surface of an outer packaging layer 6, an adhesive layer is arranged on the other surface of the outer packaging layer 6, and the adhesive layer is adhered on the outer wall surface of the elastic column body 1 and the inner cavity surface of the elastic cervical cap 2.
So set up, just can cut wantonly after medicine dressing layer 4 and the outer 6 combination of package to be applicable to different use positions, can conveniently fix on some carriers through pasting the layer simultaneously. The outer package layer 6 is a high polymer elastomer film such as a soft rubber film, a silica gel film, a polyurethane film, a polylactic acid film, a polyethylene film or a polypropylene film, and the soft rubber film or the silica gel film, and thus can be properly stretched. Wherein the polyurethane film has elasticity and air permeability, and is very comfortable for patients to use.
In the utility model, the preferable structural style that sets up to dismantling the connection between elastic column body 1 and the elastic cervical cage 2. By the arrangement, the elastic cervical shield 2 can be taken down for some patients who need not to take medicine at the cervical part clinically, so that waste is avoided.
As shown in fig. 2, in this embodiment 2, a nut 7 is embedded in a hole formed in the front end of the elastic cylinder 1, a stud 8 is embedded in the bottom of the elastic cervical cap 2, and the elastic cylinder 1 and the elastic cervical cap 2 are connected by a screw thread.
The above description is only for the preferred embodiment of the present invention, and the above specific embodiments are not intended to limit the present invention. Within the scope of the technical idea of the present invention, various modifications and alterations can be made, and any person skilled in the art can make modifications, amendments or equivalent replacements according to the above description, all belonging to the protection scope of the present invention.
Claims (8)
1. Female photodynamic gel package dressing device, its characterized in that: the vagina implanting device comprises an elastic cylinder body (1) and an elastic cervical cap (2), wherein the elastic cylinder body (1) is used for being implanted into a vagina, the elastic cervical cap (2) is installed at the front end of the elastic cylinder body (1), the elastic cervical cap (2) is used for covering and sleeving a cervix, the elastic cervical cap (2) is integrally bowl-shaped, and a small bulge (3) is arranged at the center of the bottom of the bowl of the elastic cervical cap (2) so that the shape of an inner cavity of the elastic cervical cap (2) is matched with the shape of the cervix; the surface of the outer wall of the elastic column body (1) and the surface of the inner wall and the outer wall of the elastic cervical cap (2) are both provided with a medicine dressing layer (4), the medicine dressing layer (4) is made of a soft material with wettability, and a gel type photosensitizer is soaked in the medicine dressing layer (4).
2. A female photodynamic gel encapsulation dressing apparatus according to claim 1 wherein: the back end of the elastic column body (1) is provided with a fixed adhesive tape (5), and the fixed adhesive tape (5) is used for being adhered to the skin around the pudendum.
3. A female photodynamic gel encapsulation dressing apparatus according to claim 2, wherein: the fixed glue paste (5) and the elastic column body (1) are integrally arranged.
4. A female photodynamic gel encapsulation dressing apparatus according to claim 1 wherein: the medicine dressing layer (4) is fixedly combined on the surface of an outer packaging layer (6), an adhesive layer is arranged on the other surface of the outer packaging layer (6), and the adhesive layer is adhered to the surface of the outer wall of the elastic column body (1) and the surface of the inner cavity of the elastic cervical cap (2).
5. A female photodynamic gel encapsulation dressing device according to claim 4, wherein: the drug dressing layer (4) is a silk fabric, a non-woven fabric, a cosmetic cotton, a pure cotton fabric, a biological fiber fabric, a chemical fiber fabric, a chitosan fabric or a blended fabric with uniform thickness; the outer packaging layer (6) is a soft rubber film, a latex film, a silica gel film or a polyurethane film.
6. A female photodynamic gel encapsulation dressing apparatus according to claim 1 wherein: the elastic cylinder body (1) is detachably connected with the elastic cervical cap (2).
7. A female photodynamic gel encapsulation dressing device according to claim 6, wherein: the elastic cervical cap is characterized in that a hole is formed in the front end of the elastic cylinder body (1) and a nut (7) is embedded, a stud (8) is embedded in the bottom of the elastic cervical cap (2), and the elastic cylinder body (1) is in threaded connection with the elastic cervical cap (2).
8. A female photodynamic gel encapsulation dressing device according to any one of claims 1 to 7, wherein: the elastic cylinder body (1) and the elastic cervical cap (2) are made of rubber or silica gel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921639630.8U CN211751739U (en) | 2019-09-27 | 2019-09-27 | Female photodynamic gel packaging dressing device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921639630.8U CN211751739U (en) | 2019-09-27 | 2019-09-27 | Female photodynamic gel packaging dressing device |
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| CN211751739U true CN211751739U (en) | 2020-10-27 |
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| CN201921639630.8U Active CN211751739U (en) | 2019-09-27 | 2019-09-27 | Female photodynamic gel packaging dressing device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110575612A (en) * | 2019-09-27 | 2019-12-17 | 赵志国 | Female photodynamic gel packaging dressing device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110575612A (en) * | 2019-09-27 | 2019-12-17 | 赵志国 | Female photodynamic gel packaging dressing device |
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