CN212059919U - Storage device for chemiluminescence immunoassay analyzer - Google Patents
Storage device for chemiluminescence immunoassay analyzer Download PDFInfo
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- CN212059919U CN212059919U CN202020651735.1U CN202020651735U CN212059919U CN 212059919 U CN212059919 U CN 212059919U CN 202020651735 U CN202020651735 U CN 202020651735U CN 212059919 U CN212059919 U CN 212059919U
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Abstract
The utility model discloses a storage device for chemiluminescence immunity analyzer, including storage base, translation mechanism and a plurality of storage component, translation mechanism is used for driving storage base and removes, and a plurality of storage component sets up on storage base side by side, and storage component mainly comprises reagent storage box and the capillary storage box of connection in reagent storage box top, and the reagent storage box is used for storing reagent, and the capillary storage box is used for the capillary after the storage process is peridium. The utility model has the advantages of compact structure, small, can carry out the random combination according to the detection needs.
Description
Technical Field
The utility model relates to a storage device for chemiluminescence immunoassay appearance belongs to chemiluminescence analysis technical field.
Background
Chemiluminescence immunoassay (CLIA) is a technique for detecting and analyzing various antigens, antibodies, hormones, enzymes, vitamins, drugs and the like by combining a chemiluminescence assay technique with high sensitivity and a high-specificity immunoreaction. Is an immunoassay technology developed after radioimmunoassay, enzyme immunoassay, fluoroimmunoassay and time-resolved fluoroimmunoassay. The chemiluminescence method has the advantages of high sensitivity, strong specificity, high accuracy, wide detection range and the like. Compared with the semi-quantitative enzyme-linked immunosorbent assay, the chemiluminescence assay is real quantitative, and the detection speed is higher and more convenient. Meanwhile, the chemiluminescent marker is stable, the effective period of the reagent is long, and the requirement of clinical application is greatly facilitated.
The application numbers are: CN201910774133.7, publication no: the invention patent of CN110514859A discloses a full-automatic chemiluminescence immunoassay method, which comprises the steps of firstly installing a capillary storage assembly, a capillary pushing assembly, a turntable assembly, an air blowing assembly, a sample assembly, a reagent assembly and a detection assembly, then starting the capillary pushing assembly to push out a capillary positioned in the capillary storage assembly, and sending the capillary to the turntable assembly, and conveying the capillary to the positions of the sample assembly, the air blowing assembly, the reagent assembly and the detection assembly by the rotation of the turntable assembly to realize automatic immunoassay. The carrier used in the invention is not the existing enzyme label plate or micropore plate, but the capillary tube is used, thus greatly reducing the sample usage amount and reagent usage amount, reducing the detection cost and improving the detection efficiency.
The specification discloses an immunoassay device capable of realizing the method, but the following defects still exist:
1. the capillary storage component and the reagent component are two independent components, and in the step of pushing out the capillary and the step of sucking the reagent, an independent driving device is needed for driving, so that the whole occupied space is larger, and the device of the chemiluminescence immunoassay analyzer is larger.
2. When the capillary tube is pushed out, the capillary tube pushing-out mechanism and the capillary tube storage assembly are positioned, the capillary tube pushing-out mechanism and the capillary tube storage assembly may collide, and the position accuracy of each component may be influenced after the capillary tube pushing-out mechanism is used for many times, so that the inside of the chemiluminescence immunoassay analyzer fails;
3. the capillary storage component is always communicated with the interior of the chemiluminescence immunoassay analyzer, dust can return to enter the chemiluminescence immunoassay analyzer after entering the chemiluminescence immunoassay analyzer during use, and the cleanliness of the capillary is affected to cause errors in detection results.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a storage device for chemiluminescence immunoassay appearance has compact structure, small, can carry out the advantage of making up at will according to the detection needs.
In order to solve the technical problem, the utility model discloses the technical scheme who adopts is:
a storage device for a chemiluminescence immunoassay analyzer comprises a storage base, a translation mechanism and a plurality of storage assemblies, wherein the translation mechanism is used for driving the storage base to move, the plurality of storage assemblies are arranged on the storage base side by side, each storage assembly mainly comprises a reagent storage box and a capillary storage box connected above the reagent storage box, the reagent storage box is used for storing a reagent, and the capillary storage box is used for storing coated capillaries; the side surface of the reagent storage box is connected with an L-shaped installation part, a clamping hook is arranged on the L-shaped installation part, a clamping groove is formed in the side surface of the storage base, the clamping hook can be clamped with the clamping groove, two positioning bulges are arranged on the bottom surface of the reagent storage box, limiting clamping grooves are formed in the positioning bulges, and a bolt clamping area is formed between the two limiting clamping grooves; the storage base is provided with a transverse groove, the transverse groove divides the storage base into a left part and a right part, the left part is lower than the right part, the right part is provided with a plurality of cutting grooves which are communicated with the transverse groove, a plurality of lugs of the right part are formed by the cutting grooves between the lugs, the lug sides are provided with through holes, the clamping hooks of the L-shaped installation part are clamped with the clamping grooves, two positioning protrusions are positioned in the positioning protrusion installation areas, and the positioning protrusions are limited by bolts penetrating through the through holes on the lugs, so that the storage assembly is fixed on the storage base.
The reagent storage box is internally provided with a reagent cavity, the side wall of the reagent storage box is provided with a reagent tube, the reagent tube is communicated with the reagent cavity, the side wall of the reagent storage box opposite to the reagent tube is provided with a rubber film, and a reagent in the reagent cavity can flow out of the reagent tube after the rubber film is extruded and forms a reagent drop at the outlet position of the reagent tube.
The capillary storage device comprises a capillary storage box, capillary tubes, a partition plate and a rubber diaphragm, wherein the capillary tube storage box is formed by dividing the capillary tube storage box through the partition plate, the width of the capillary tube storage cavity is larger than the diameter of each capillary tube by 0.5-1mm, the capillary tubes are sequentially stacked in the capillary tube storage cavity from top to bottom, a left through hole and a right through hole are respectively formed in the left side and the right side of the bottom of the capillary tube storage box, the left through hole and the right through hole are communicated with the capillary tube storage cavity, the rubber diaphragm is arranged at the positions.
Further optimize, rubber diaphragm central point puts and is provided with the mar that is cross, Y style of calligraphy, X type structure to in-and-out back of capillary, the rubber diaphragm can be closed.
Wherein, still install the cleaning solution case on the storage base.
It should be noted that the translation mechanism is an air pressure translation mechanism, a hydraulic translation mechanism, a rack and pinion translation mechanism, a lead screw translation mechanism or an electric push rod translation mechanism.
Wherein, translation mechanism is connected with the detection sensor, and the detection sensor is used for detecting storage component's position.
Further optimize, capillary storage box and reagent storage box side are provided with the blotter, and the blotter is provided with the round hole, and the position of round hole corresponds with the position of left side through-hole and rubber lamella.
Compared with the prior art, the utility model discloses following beneficial effect has:
the storage device comprises the agent storage box and the capillary storage box, so that the agent storage box and the capillary storage box form an integrated structure, and the agent storage box and the capillary storage box can move along with each other in actual use, so that a driving device is reduced, and the volume of the chemiluminescence immunoassay analyzer is further reduced; meanwhile, in actual use, storage components (an agent storage box and a capillary storage box) can be additionally arranged according to detection requirements, the storage components can be increased or decreased according to actual requirements, the requirements of different users can be met, and the users can select reagents according to samples to be detected and then combine the reagents at will; at the same time, the storage capacity of the capillary tube is also increased.
More importantly, because be provided with the rubber lamella in left side through-hole and right side through-hole department, the rubber lamella can be opened or close, can carry out the shutoff to left side through-hole and right side through-hole, plays the purpose of protection to the capillary, maintains the humidity in capillary storage cavity, also can reduce the dust simultaneously and enter into to capillary storage cavity, avoids leading to the fact the pollution to the capillary, and then guarantees the accuracy of testing result, improves and detects the rate of accuracy.
Simultaneously, be provided with the blotter in capillary storage box and reagent storage box side, when releasing the capillary, capillary ejecting device is when the capillary storage box contacts the realization location, under the protection of blotter, can avoid capillary ejecting device and capillary storage box to take place the striking, has avoided influencing the position precision between inside each part because of the striking, guarantees inside each part normal operating, reduces the probability that chemiluminescence immunoassay appearance broke down.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention, and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is a schematic diagram of the position relationship between the storage base and the storage assembly of the present invention.
Fig. 3 is the overall structure diagram of the storage base of the present invention.
Fig. 4 is a schematic view of another side structure of fig. 3 according to the present invention.
Fig. 5 is a schematic view of the overall structure of the storage module of the present invention.
Fig. 6 is a left side view of fig. 5 according to the present invention.
Fig. 7 is the overall structure schematic diagram of the capillary tube ejecting device of the present invention.
Fig. 8 is a schematic sectional view of a pushing frame in the capillary tube pushing device of the present invention.
Fig. 9 is an explosion diagram of the pushing assembly in the capillary pushing device according to the present invention.
Fig. 10 is an exploded view of the positioning assembly of the capillary releasing device according to the present invention.
Reference numerals: 801 storage base, 802 translation mechanism, 803 storage assembly, 804 reagent storage box, 805 capillary storage box, 806L-shaped mounting part, 807 trip, 808 clamping groove, 809 positioning projection, 810 positioning projection mounting area, 811 reagent tube, 812 rubber membrane, 813 reagent droplet, 814 left through hole, 815 right through hole, 816 rubber membrane flap, 817 cleaning solution box, 818 slide rail, 819 slider, 820 rack and pinion translation mechanism, 821 translation motor, 822 translation rack, 824 buffer pad, 825 round hole, 826 spacing clamping groove, 827 transverse groove, 828 dividing groove, 829 through hole, 830 bolt, 831 lug.
901 positioning support, 902 positioning component, 903 positioning rack, 904 positioning rod, 905 blocking piece, 906 spring, 907 first limit boss, 908 second limit boss, 909 pushing component, 910 pushing rack, 911 push rod, 912 pushing driving device, 913 pushing motor, 914 pushing rack, 915 pushing gear, 916 extruding rod, 917 adjusting bolt, 918 threaded hole, 919 guide hole, 920 sliding component, 921 sliding guide rail, 922 positioning slide block, 923 pushing slide block.
Detailed Description
The present invention will be further described with reference to the following examples, which are only some, but not all, of the examples of the present invention. Based on the embodiments in the present invention, other embodiments used by those skilled in the art without creative work belong to the protection scope of the present invention.
Example 1
A storage device for a chemiluminescent immunoassay analyzer, the storage device is used for being installed inside the chemiluminescent immunoassay analyzer and used for providing a capillary and a reagent;
the concrete structure is as follows: the device comprises a storage base 801, a translation mechanism 802 and a plurality of storage assemblies 803, wherein the translation mechanism 802 is used for driving the storage base 801 to move, the plurality of storage assemblies 803 are arranged on the storage base 801 side by side, each storage assembly 803 mainly comprises a reagent storage tank 804 and a capillary storage tank 805 connected above the reagent storage tank 804, the reagent storage tank 804 is used for storing reagent, and the capillary storage tank 805 is used for storing coated capillaries; the side surface of the reagent storage box 804 is connected with an L-shaped installation part 806, a clamping hook 807 is arranged on the L-shaped installation part 806, a clamping groove 808 is arranged on the side surface of the storage base 801, the clamping hook 807 can be clamped with the clamping groove 808, two positioning protrusions 809 are arranged on the bottom surface of the reagent storage box 804, a limiting clamping groove 826 is arranged on the positioning protrusions 809, and a bolt clamping area is formed between the two limiting clamping grooves 826; the storage base 801 is provided with a transverse groove 827, the transverse groove 827 divides the storage base 801 into a left part and a right part, the left part is lower than the right part, the right part is provided with a plurality of dividing grooves 826, the dividing grooves 826 are communicated with the transverse groove 827, the dividing grooves 826 divide a plurality of bumps 831 on the right part, the dividing grooves 826 between the bumps 831 form a positioning protrusion mounting area 810, the side of the bump 831 is provided with a through hole 829, after the hook 807 of the L-shaped mounting portion 806 is clamped with the clamping groove 808, the two positioning protrusions 809 are located in the positioning protrusion mounting area 810, and the storage assembly 803 is limited by a bolt 830 penetrating through the through hole 829 on the bump 831, so that the storage assembly 803 is fixed on the storage base 801.
The storage base 801 is used for being slidably mounted on a capillary pushing device of a chemiluminescence immunoassay analyzer, and the storage base 801 is driven to move on the capillary pushing device of the chemiluminescence immunoassay analyzer through a translation mechanism 802.
Thus, one storage component 803 can be used for storing the capillary and the reagent, and can share one translation mechanism 802 to realize movement, so that the use amount of a driving device is reduced, the volume of the chemiluminescence immunoassay analyzer can be effectively reduced, and the structure is more compact; the reagent storage box 804 is clamped with a clamping groove 808 arranged on the side surface of the storage base 801 through a clamping hook 807, then a bolt 830 clamping area is formed on the positioning protrusion 809 through two positioning protrusions 809 arranged on the bottom surface of the reagent storage box 804, the two positioning protrusions 809 are positioned in the positioning protrusion mounting area 810, and the storage group is fixed on the storage base 801 by limiting through the bolt 830 penetrating through a through hole 829 on a bump 831; can carry out dismouting storage component 803 according to specific sample condition in the use of reality, place required reagent at reagent storage box 804, can realize the independent assortment of reagent, improve the utility model discloses an application range.
Further, reagent storage box 804 has a reagent chamber therein, a side wall of reagent storage box 804 is provided with a reagent tube 811, reagent tube 811 is communicated with the reagent chamber, a side wall of reagent storage box 804 opposite to reagent tube 811 is provided with a rubber film 812, the reagent in the reagent chamber can flow out from reagent tube 811 after pressing rubber film 812, and a reagent drop 813 is formed at an outlet position of reagent tube 811.
The capillary storage cavity is formed by dividing the capillary storage box 805 through a partition plate, the width of the capillary storage cavity is larger than the diameter of a capillary tube by 0.5-1mm, a plurality of capillaries are sequentially stacked in the capillary storage cavity from top to bottom, a left through hole 814 and a right through hole 815 are respectively arranged on the left side and the right side of the bottom of the capillary storage box 805, the left through hole 814 and the right through hole 815 are communicated with the capillary storage cavity, a rubber diaphragm 816 is arranged at the left through hole 814 and the right through hole 815, and the rubber diaphragm 816 can be opened or closed.
In this embodiment, the width of the capillary storage chamber is greater than 0.7mm of the capillary diameter.
Thus, in actual use, reagent droplets 813 are formed at the orifice of the reagent tube 811 by pressing the rubber membrane 812 to supply the capillary with reagent; and can seal the capillary storage chamber through the rubber lamella 816 that sets up for inside the capillary storage chamber keeps the relatively stable state, and inside rubber lamella 816 closed, outside air or dust can not enter into the capillary storage chamber, can effectual reduction external factor to the influence of testing result, can effectual improvement testing result's accuracy.
Further optimization, scratches in a cross-shaped, Y-shaped and X-shaped structure are arranged at the center of the rubber flap 816, so that the rubber flap 816 can be closed after the capillary tube enters and exits; therefore, the process of pushing out the capillary tube can be smoother, and the pushing out process is prevented from being blocked; meanwhile, the sealing performance of the capillary tube can be guaranteed after the capillary tube is pushed out.
Wherein, the storage base 801 is also provided with a cleaning liquid tank 817.
It should be noted that the translation mechanism 802 is an air pressure translation mechanism, a hydraulic translation mechanism, a rack and pinion translation mechanism, a lead screw translation mechanism, or an electric push rod translation mechanism, and only needs to be able to push the storage base 801 to move.
In actual use, the storage base 801 is slidably mounted on a capillary pushing-out device of a chemiluminescence immunoassay analyzer, the storage base 801 is slidably mounted on the capillary pushing-out device through a sliding rail 818 and a sliding block 819, and the storage base 801 is driven to move on the capillary pushing-out device through a translation mechanism 802; in this embodiment, the translation mechanism 802 is a rack and pinion translation mechanism, the rack and pinion translation mechanism 820 includes a translation motor 821, a translation gear and a translation rack 822, the translation motor 821 is fixedly installed on the capillary pushing device, the translation rack 822 is fixedly installed on the storage base 801, the translation gear is installed on the translation motor 821 and then meshed with the translation gear, and the translation motor 821 rotates to drive the storage base 801.
In actual use, the translation mechanism 802 is connected with a detection sensor for detecting the position of the storage component 803; the translation mechanism 802 is started and stopped according to information fed back by the detection sensor.
Further preferably, in this embodiment, the side surfaces of the capillary storage tank 805 and the reagent storage tank 804 are provided with cushions 824, the cushions 824 are provided with circular holes 825, and the positions of the circular holes 825 correspond to the positions of the left through hole 814 and the rubber flap 816.
Thus, the buffering cushion 824 can play a good role in buffering, and prevent the capillary pushing device in the chemiluminescence immunoassay analyzer from colliding with the storage component 803 in the positioning process when pushing out the capillary; the capillary pushing device in the chemiluminescence immunoassay analyzer is mainly used for pushing the capillary out of the capillary storage box 805 so that the capillary enters a turntable assembly in the chemiluminescence immunoassay analyzer; in addition, the capillary pushing device in the chemiluminescence immunoassay analyzer is also used for pressing the side wall of the reagent storage tank 804 to form a rubber membrane 812, so that a reagent droplet 813 is formed at the outlet position of the reagent tube 811.
For further understanding of the present invention, the specific structure of the capillary pushing-out device in the present embodiment is further described below:
a capillary tube pushing device comprises a positioning support 901, a positioning component 902 and a pushing component 909, wherein the positioning support 901 is used for being installed on a fixed seat 7 installed on a bottom plate in a chemiluminescence immunoassay analyzer in a sliding mode, the positioning component 902 and the pushing component 909 are installed on the positioning support 901 in a sliding mode, the positioning component 902 is located in front of the pushing component 909, the positioning component 902 and the pushing component 909 are connected with a pushing driving device 912, the pushing driving device 912 can drive the positioning component 902 and the pushing component 909 to move on the positioning support 901, the positioning component 902 is connected with a pressing rod 916, the pressing rod 916 is used for pressing a rubber membrane 812 arranged on a reagent storage box 804 in a storage device in the chemiluminescence immunoassay analyzer, the positioning component 902 is used for positioning a left through hole 814 position arranged on a capillary tube storage box 805 in the storage device in the chemiluminescence immunoassay analyzer, and the pushing component 909 is used for enabling a capillary tube to be arranged on a capillary tube storage box 805 in the storage device in the The right side through hole 815 is pushed out.
In actual use, the storage base 801 is slidably mounted on the positioning bracket 901 through the slide rail 818 and the slide 819. Wherein, the translation mechanism 802 drives the storage base 801 to move on the positioning bracket 901, so that one of the storage assemblies 803 is aligned with the positioning assembly 902, at this time, the right through hole 815 of the storage assembly 803 is aligned with the turntable assembly 1, and the left through hole 814 is exactly aligned with the left through hole 814; the pushing-out driving device 912 connected with the positioning assembly 902 drives the positioning assembly 902 to align with the storage assembly 803, and then the pushing-out driving device 912 connected with the pushing assembly 909 assembly drives the pushing assembly 909 to push the capillary tubes in the capillary storage tank 805 in the storage assembly 803 into the turntable assembly 1.
The positioning bracket 901 is driven by the first driving device 11 to move on the fixed base 7, so that the storage device is close to or far away from the turntable assembly 1.
Further thinning, the positioning assembly 902 includes a positioning rack 903, a positioning rod 904, a blocking piece 905 and a spring 906, the positioning rack 903 is connected with one push-out driving device 912, the push-out driving device 912 is used for driving the positioning rack 903 to move, the positioning rod 904 is hollow, one end of the positioning rod 904 is conical, the other end of the positioning rod 904 is provided with a first limiting boss 907, one conical end of the positioning rod 904 is provided with a second limiting boss 908, the positioning rod 904 is slidably mounted on the positioning rack 903, and the two rear ends of the positioning rod 903 extend out of the positioning rack 903, the spring 906 and the blocking piece 905 are both sleeved on the positioning rod 904, the blocking piece 905 is close to the first limiting boss 907, the spring 906 is close to the second limiting boss 908, under the action of the spring 906, the blocking piece 905 is pressed on the side surface of the positioning rack 903, a push rod 911 in the pushing assembly 909 can pass through, the length of the squeeze lever 916 is shorter than the length of the positioning rod 904 extending out of the right end of the positioning housing 903.
Thus, in practical use, the push-out driving device 912 drives the positioning rack 903 to move, the positioning rack 903 drives the positioning rod 904 to move, and the positioning rod 904 is enabled to approach the capillary storage tank 805 in the storage assembly 803 until the end of the positioning rod 904 is aligned with and contacts with the left through hole 814 arranged on the capillary storage tank 805, at this time, after the positioning rod 904 contacts with the capillary storage tank 805, the positioning rod 904 will compress the spring 906, the purpose of buffering is achieved through the deformation of the spring 906, and after the positioning is finished, the push-out driving device 912 stops driving; at this time, the pushing element 909 will perform a capillary pushing-out step.
Further, the pushing assembly 909 includes a pushing frame 910 and a pushing rod 911, the pushing frame 910 is connected to another pushing driving device 912, the pushing driving device 912 can drive the pushing frame 910 to move, and one end of the pushing rod 911 is connected to the pushing frame 910, and the other end of the pushing rod 911 extends into the positioning rod 904 and can extend out of the positioning rod 904.
After the positioning rod 904 is positioned, the pushing-out driving device 912 connected with the pushing assembly 909 drives the pushing rack 910 to move, the pushing rack 910 drives the pushing rod 911 to move, the end part of the towing rod penetrates through the positioning rod 904 and extends into the capillary storage cavity of the capillary storage cavity 805, the capillary of the capillary storage cavity is pushed out, and the capillary enters the turntable assembly 1; after the capillary tube is pushed into the turntable assembly 1 by the towing rod, the push rod 911 firstly makes a return stroke motion, and then the positioning rod 904 makes a return stroke motion; the positioning and pushing steps are then completed.
Like this, the locating lever 904 can realize the purpose of location, can play the effect of support direction to push rod 911 secondly, avoids push rod 911 to play the effect of protection at the in-process rupture that promotes the capillary, to push rod 911.
Further optimization, wherein the pushing assembly 909 further comprises an adjusting bolt 917, the pushing frame 910 is provided with a threaded hole 918 and a guide hole 919, the threaded hole 918 is communicated with the guide hole 919, the adjusting bolt 917 is matched with the threaded hole 918, the push rod 911 is connected with the pushing frame 910 through the adjusting bolt 917, one end of the push rod 911 penetrates through the guide hole 919 and then is fixedly connected with the end of the adjusting bolt 917, the other end of the push rod 911 extends into the positioning rod 904, and the push rod 911 can extend out of the positioning rod 904 after the positioning frame 903 moves; thus, fine adjustment of the push rod 911 can be achieved by screwing the adjusting bolt 917.
Further, the positioning assembly 902 and the pushing assembly 909 are respectively connected with the two pushing-out driving devices 912 through the sliding assembly 920, the sliding assembly 920 includes a sliding guide rail 921, a positioning slider 922 and a pushing-out slider 923, the sliding guide rail 921 is fixedly mounted on the positioning bracket 901, the positioning slider 922 and the pushing-out slider 923 are slidably disposed on the sliding guide rail 921, the positioning slider 922 is connected with the positioning assembly 902, the pushing-out slider 923 is connected with the pushing assembly 909, and the positioning slider 922 and the pushing-out slider 923 are respectively connected with the pushing-out driving devices 912; in this way, the positioning frame 903 and the pushing frame 910 can be made more stable when moving.
The pushing-out driving device 912 includes a pushing-out motor 913, a pushing-out rack 914 and a pushing-out gear 915, the pushing-out motor 913 is fixedly mounted on the positioning bracket 901, the pushing-out gear 915 is fixedly mounted on an output shaft of the pushing-out motor 913, the pushing-out rack 914 is mounted on the positioning slider 922 or the pushing-out slider 923, and the pushing-out gear 915 and the pushing-out rack 914 are engaged with each other.
It should be noted that positioning assembly 902 also includes a droplet sensor, the droplet sensor is connected to the pushing out driving device 912 connected to positioning assembly 902, the droplet sensor is used to detect the size of reagent droplet 813 formed at the nozzle of reagent tube 811 connected to reagent storage box 804 in the storage device of the chemiluminescence immunoassay analyzer; thus, in actual use, the size of the reagent droplet 813 is detected by the droplet sensor, the positioning frame 903 is driven to move by the push-out driving device 912 connected to the positioning module 902 according to the information detected by the droplet sensor, and if the size of the reagent droplet 813 is too small, the positioning module 902 is driven by the driving device, so that the pressing rod 916 continues to press the rubber film 812, and the volume of the reagent droplet 813 increases; ensure to extrude reagent drops 813 with proper size and avoid causing reagent waste.
For further understanding of the present invention, the storage device in the chemiluminescence immunoassay analyzer of the present embodiment will be further described below:
the storage device is used for being installed inside the chemiluminescence immunoassay analyzer and used for providing the capillary and the reagent; the concrete structure is as follows: the device comprises a storage base 801, a translation mechanism 802 and a plurality of storage assemblies 803, wherein the translation mechanism 802 is used for driving the storage base 801 to move, the plurality of storage assemblies 803 are arranged on the storage base 801 side by side, each storage assembly 803 mainly comprises a reagent storage tank 804 and a capillary storage tank 805 connected above the reagent storage tank 804, the reagent storage tank 804 is used for storing reagent, and the capillary storage tank 805 is used for storing coated capillaries; the side surface of the reagent storage box 804 is connected with an L-shaped installation part 806, a clamping hook 807 is arranged on the L-shaped installation part 806, a clamping groove 808 is arranged on the side surface of the storage base 801, the clamping hook 807 can be clamped with the clamping groove 808, two positioning protrusions 809 are arranged on the bottom surface of the reagent storage box 804, a limiting clamping groove 826 is arranged on the positioning protrusions 809, and a bolt clamping area is formed between the two limiting clamping grooves 826; the storage base 801 is provided with a transverse groove 827, the transverse groove 827 divides the storage base 801 into a left part and a right part, the left part is lower than the right part, the right part is provided with a plurality of dividing grooves 826, the dividing grooves 826 are communicated with the transverse groove 827, the dividing grooves 826 divide a plurality of bumps 831 on the right part, the dividing grooves 826 between the bumps 831 form a positioning protrusion mounting area 810, the side of the bump 831 is provided with a through hole 829, after the hook 807 of the L-shaped mounting portion 806 is clamped with the clamping groove 808, the two positioning protrusions 809 are located in the positioning protrusion mounting area 810, and the storage assembly 803 is limited by a bolt 830 penetrating through the through hole 829 on the bump 831, so that the storage assembly 803 is fixed on the storage base 801.
The storage base 801 is used for being slidably mounted on a capillary pushing device of a chemiluminescence immunoassay analyzer, and the storage base 801 is driven to move on the capillary pushing device of the chemiluminescence immunoassay analyzer through a translation mechanism 802.
Further, reagent storage box 804 has a reagent chamber therein, a side wall of reagent storage box 804 is provided with a reagent tube 811, reagent tube 811 is communicated with the reagent chamber, a side wall of reagent storage box 804 opposite to reagent tube 811 is provided with a rubber film 812, the reagent in the reagent chamber can flow out from reagent tube 811 after pressing rubber film 812, and a reagent drop 813 is formed at an outlet position of reagent tube 811.
The capillary storage cavity is formed by dividing the capillary storage box 805 through a partition plate, the width of the capillary storage cavity is larger than the diameter of a capillary tube by 0.5-1mm, a plurality of capillaries are sequentially stacked in the capillary storage cavity from top to bottom, a left through hole 814 and a right through hole 815 are respectively arranged on the left side and the right side of the bottom of the capillary storage box 805, the left through hole 814 and the right through hole 815 are communicated with the capillary storage cavity, a rubber diaphragm 816 is arranged at the left through hole 814 and the right through hole 815, and the rubber diaphragm 816 can be opened or closed.
In this embodiment, the width of the capillary storage chamber is greater than 0.7mm of the capillary diameter.
Further optimization, scratches in a cross-shaped, Y-shaped and X-shaped structure are arranged at the center of the rubber flap 816, so that the rubber flap 816 can be closed after the capillary tube enters and exits; therefore, the process of pushing out the capillary tube can be smoother, and the pushing out process is prevented from being blocked; meanwhile, the sealing performance of the capillary tube can be guaranteed after the capillary tube is pushed out.
Wherein, the storage base 801 is also provided with a cleaning liquid tank 817.
It should be noted that the translation mechanism 802 is an air pressure translation mechanism, a hydraulic translation mechanism, a rack and pinion translation mechanism, a lead screw translation mechanism, or an electric push rod translation mechanism, and only needs to be able to push the storage base 801 to move.
In actual use, the storage base 801 is slidably mounted on a capillary pushing-out device of a chemiluminescence immunoassay analyzer, the storage base 801 is slidably mounted on the capillary pushing-out device through a sliding rail 818 and a sliding block 819, and the storage base 801 is driven to move on the capillary pushing-out device through a translation mechanism 802; in this embodiment, the translation mechanism 802 is a rack and pinion translation mechanism, the rack and pinion translation mechanism 820 includes a translation motor 821, a translation gear and a translation rack 822, the translation motor 821 is fixedly installed on the capillary pushing device, the translation rack 822 is fixedly installed on the storage base 801, the translation gear is installed on the translation motor 821 and then meshed with the translation gear, and the translation motor 821 rotates to drive the storage base 801.
In actual use, the translation mechanism 802 is connected with a detection sensor for detecting the position of the storage component 803; the translation mechanism 802 is started and stopped according to information fed back by the detection sensor.
Further preferably, in this embodiment, the side surfaces of the capillary storage tank 805 and the reagent storage tank 804 are provided with cushions 824, the cushions 824 are provided with circular holes 825, and the positions of the circular holes 825 correspond to the positions of the left through hole 814 and the rubber flap 816.
The capillary pushing device in the chemiluminescence immunoassay analyzer is mainly used for pushing the capillary out of the capillary storage box 805 so that the capillary enters a turntable assembly in the chemiluminescence immunoassay analyzer; in addition, the capillary pushing device in the chemiluminescence immunoassay analyzer is also used for pressing the side wall of the reagent storage tank 804 to form a rubber membrane 812, so that a reagent droplet 813 is formed at the outlet position of the reagent tube 811.
While the preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the appended claims be interpreted as including the preferred embodiment and all such alterations and modifications as fall within the scope of the invention. The above description is only exemplary of the present invention and should not be taken as limiting, and all changes, equivalents, and improvements made within the spirit and principles of the present invention should be understood as being included in the scope of the present invention.
Claims (7)
1. A storage device for a chemiluminescence immunoassay analyzer is characterized in that: the reagent storage device comprises a storage base, a translation mechanism and a plurality of storage assemblies, wherein the translation mechanism is used for driving the storage base to move, the plurality of storage assemblies are arranged on the storage base side by side, each storage assembly mainly comprises a reagent storage box and a capillary storage box connected above the reagent storage box, the reagent storage box is used for storing a reagent, and the capillary storage box is used for storing a coated capillary; the side surface of the reagent storage box is connected with an L-shaped installation part, a clamping hook is arranged on the L-shaped installation part, a clamping groove is formed in the side surface of the storage base, the clamping hook can be clamped with the clamping groove, two positioning bulges are arranged on the bottom surface of the reagent storage box, limiting clamping grooves are formed in the positioning bulges, and a bolt clamping area is formed between the two limiting clamping grooves; the storage base is provided with a transverse groove, the transverse groove divides the storage base into a left part and a right part, the left part is lower than the right part, the right part is provided with a plurality of cutting grooves which are communicated with the transverse groove, a plurality of lugs of the right part are formed by the cutting grooves between the lugs, the lug sides are provided with through holes, the clamping hooks of the L-shaped installation part are clamped with the clamping grooves, two positioning protrusions are positioned in the positioning protrusion installation areas, and the positioning protrusions are limited by bolts penetrating through the through holes on the lugs, so that the storage assembly is fixed on the storage base.
2. The storage device for a chemiluminescent immunoassay analyzer of claim 1, wherein: the reagent storage box is internally provided with a reagent cavity, the side wall of the reagent storage box is provided with a reagent tube, the reagent tube is communicated with the reagent cavity, the side wall of the reagent storage box opposite to the reagent tube is provided with a rubber film, and a reagent in the reagent cavity can flow out of the reagent tube after the rubber film is extruded, and a reagent liquid drop is formed at the outlet position of the reagent tube.
3. The storage device for a chemiluminescent immunoassay analyzer according to claim 2, wherein: the capillary storage box is internally divided by a partition plate to form a capillary storage cavity, the width of the capillary storage cavity is 0.5-1mm larger than the diameter of a capillary, a plurality of capillaries are sequentially stacked in the capillary storage cavity from top to bottom, a left through hole and a right through hole are respectively formed in the left side and the right side of the bottom of the capillary storage box, the left through hole and the right through hole are communicated with the capillary storage cavity, rubber diaphragms are arranged at the left through hole and the right through hole, and can be opened or closed.
4. The storage device for a chemiluminescent immunoassay analyzer of claim 3, wherein: the central position of the rubber valve is provided with scratches which are in cross, Y-shaped and X-shaped structures, so that the rubber valve can be closed after the capillary tube enters and exits.
5. The storage device for a chemiluminescent immunoassay analyzer of claim 1, wherein: the translation mechanism is a pneumatic translation mechanism, a hydraulic translation mechanism, a rack and pinion translation mechanism, a lead screw translation mechanism or an electric push rod translation mechanism.
6. The storage device for a chemiluminescent immunoassay analyzer of claim 1, wherein: the translation mechanism is connected with a detection sensor, and the detection sensor is used for detecting the position of the storage assembly.
7. The storage device for a chemiluminescent immunoassay analyzer according to claim 3 or 4, wherein: the side surfaces of the capillary storage box and the reagent storage box are provided with buffer pads, the buffer pads are provided with round holes, and the positions of the round holes correspond to the positions of the left through hole and the rubber diaphragm.
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