CN211869745U

CN211869745U - Automatic partial shipment device of radioactive solid powder

Info

Publication number: CN211869745U
Application number: CN202020201910.7U
Authority: CN
Inventors: 徐新盛; 阳国桂; 杜泽天
Original assignee: Beijing Xiantong International Pharmaceutical Technology Co ltd
Current assignee: Beijing Xiantong International Pharmaceutical Technology Co ltd
Priority date: 2020-02-24
Filing date: 2020-02-24
Publication date: 2020-11-06
Anticipated expiration: 2030-02-24

Abstract

The invention discloses an automatic subpackaging device for radioactive solid powder. The system comprises a controller, a human-computer interface, a bracket, a split charging assembly, a driver and a weight sensor; the split charging assembly comprises a split charging hopper and a split charging head, and the split charging head is a screw split charging device and has a sealing function; the driver has two degrees of freedom of rotation and extension, the rotation speed of the driving screw controls the release speed of the powder, the release is started through the extension movement, and the extension movement seals the subpackaging head; and (5) obtaining a subpackaging quantitative feedback signal by using a sensor below the subpackaging head, and carrying out quantitative subpackaging. Compared with the prior art, the automatic partial shipment device of radioactive solid powder realized automatic, accurate, safe trace partial shipment of radioactive powder.

Description

Automatic partial shipment device of radioactive solid powder

Technical Field

The utility model belongs to the technical field of the pharmaceutical production equipment, concretely relates to automatic partial shipment device of radioactive solid powder.

Background

China is the major liver disease country, the incidence of liver cancer is the first worldwide, and there are 20 new liver cancer cases every day, and China accounts for 10 cases. Based on⁹⁰The radioactive embolism of the Y microsphere is an effective means for treating primary liver cancer at present, can obviously prolong the life cycle of patients and improve the life quality. For a small number of patients the number of patients,⁹⁰y-microsphere therapy can degrade tumors, allowing for surgical resection or liver transplantation. Primary liver cancer ranks fifth in the incidence of malignant tumors in the world, ranks third in the mortality of tumors, and more than 60% of patients lose the opportunity to receive radical treatment (hepatectomy, liver transplantation) when liver cancer is diagnosed.

⁹⁰The Y microsphere is a low-toxicity liver cancer-targeting preparation, and is prepared from millions of radioactive carriers⁹⁰Y, injecting radioactive microspheres (the diameter is 20-30 mu m) into hepatic artery by a doctor through a catheter intervention method, allowing the microspheres to enter corresponding liver tissues through arterial blood flow and be retained in tumor peripheral blood vessels to continuously generate rays to kill tumor tissues, so that the focus receives local high-dose radiotherapy and exerts partial embolism effect, and meanwhile, the influence on non-tumor tissues and other organs is small, and liver cancer cells are killed efficiently and selectively.⁹⁰The average grain diameter of the Y microsphere is 20-30 mu m, and the Y microsphere is used as radioactive powder emitting beta rays, the subpackaging operation is carried out in an operation box with radiation protection, the subpackaging amount is 20-500mg, and the subpackaging precision requirement is within 2%. If manual subpackage is adopted, the manipulator can be used for assisting, the subpackage action is limited, and precise subpackage operation cannot be carried out. There is no mature solution for accurate automated dispensing of radioactive powder.

The non-radioactive powder split charging is generally carried out by adopting a screw split charging device, and the screw powder split charging device is widely used in the field of medicine split charging. However, such dispensers cannot be directly used for dispensing radioactive powder. There are mainly four reasons: 1. the split charging amount of the screw split charging machine is usually more than 100mg, and the split charging precision is difficult to ensure for the split charging amount less than 100 mg. 2.⁹⁰The Y microspheres have good particle size uniformity and good fluidity and are commercially availableThe screw racking machines all have the problem of powder leakage in different degrees, which causes inaccurate loading and radioactive powder scattering. 3. The conventional powder screw racking machine does not consider the requirement of ionizing radiation resistance, and logic circuits and devices are directly exposed to the ionizing radiation environment to cause equipment failure. 4. The conventional powder screw racking machine does not consider the requirement of small total packaging amount of the radiopharmaceuticals, and the conventional powder screw racking machine is huge in equipment and inconvenient for radiation protection.

The technical field of radioactive isotopes also demands the subpackaging of radioactive powder, and CN2543185Y discloses a technology for subpackaging radioactive particles for oilfield tracing in a dumping manner, and the scheme is simple and extensive and is not suitable for the micro-precise subpackaging of radioactive medicines.

Disclosure of Invention

To prior art not enough, for satisfying the partial shipment demand of medical radioactive powder, the utility model provides a radioactive solid powder's automatic partial shipment device, it adopts weighing sensor based on screw rod partial shipment principle, has realized the automatic quantitative partial shipment of radioactive powder of 1-1000mg loading, satisfies radiation protection simultaneously, reduces radioactive contamination's demand, and this partial shipment device and medicine direct contact's material can be convenient dismantlement and installation in addition, and is easily clean, satisfies the requirement of pharmaceutical production GMP standard.

The utility model discloses an automatic partial shipment device of radioactive solid powder, which comprises a controller, a human-computer interface, a bracket, a partial shipment component 1, a driver 2 and a weight sensor 3; the sub-packaging assembly 1 comprises a sub-packaging hopper 4 at the upper side and a sub-packaging head 5 at the right lower side; the driver 2 is arranged at the upper end of the bracket and comprises a rotating motor, a telescopic motor and a transmission lever; the tail end of the transmission rod is meshed and connected with a transmission shaft at the upper part of the sub-assembly 1 through a gear; the screw is connected with the lower part of the transmission shaft, and a stirring paddle is arranged on the screw; the screw rod and the outlet of the subpackaging head 5 are sealed through threads; the weight sensor 3 is arranged on the bracket and is positioned right below the sub-packaging head 5; the controller controls the human-machine interface, the weight sensor 3 and the driver 2, respectively.

The material of the distribution hopper 4 is selected from one of glass, plastic or aluminum, and is preferably transparent plastic.

The depth of the thread groove of the screw is one fourth of the diameter of the screw, and the thread pitch is 4 times of the diameter of the screw.

The human-computer interface is provided with a radiation protection protective layer.

The driver has two degrees of freedom of rotation and extension of a driving screw rod, the release speed of the powder is controlled by the rotation speed of the driving screw rod, the release is started through extension movement, and the subpackaging head is sealed through retraction movement. And (5) obtaining a subpackaging quantitative feedback signal by using a sensor below the subpackaging head, and carrying out quantitative subpackaging. The device realizes the automatic, accurate and safe micro-packaging of radioactive powder. Wherein, the partial shipment subassembly is detachable subassembly, conveniently changes and clean. Before the partial shipment begins, install the partial shipment subassembly on the partial shipment device, be connected partial shipment subassembly and driver through the gear, then, shift the powder to the partial shipment hopper to place partial shipment receiving container at the first lower extreme of partial shipment, the tare weight before the sensor survey partial shipment, control system sets for the sensor and returns to zero, accessible controller sets up partial shipment volume and the partial shipment deviation that allows. The loading amount can be set to 1-1000 mg. After the start of dispensing by command, the actuator is extended and rotated through an angle and then retracted as a cycle. The rotation angle can be adjusted arbitrarily by a program to obtain a balance of dispensing speed and accuracy. The frequency of the cycle is adjustable according to the difference between the current quantity and the set value of the loading quantity, and the range is from 1 to 500 times/min. The powder falls into the receiving bottle below during each cycle. The sensor measures the powder filling amount in the receiving bottle in real time, and when the powder filling amount is close to a set filling amount value, the circulating frequency can be reduced, and the subpackaging accuracy is ensured to meet the requirement. And when the sensor detects that the filling quantity requirement is met, stopping the circulation and finishing the sub-packaging.

Compared with the prior art, the automatic partial shipment device of radioactive solid powder have following characteristics:

1. the common screw rod split charging device has no sealing performance, has the problems of powder scattering and is not suitable for split charging of radioactive powder, in particular to the split charging of radioactive microspheres with high fluidity. The split charging device has self-sealing performance, and solves the problem of scattering of split charging of high-fluidity radioactive powder.

2. The split charging of radioactive powder is not suitable for manual operation, the scheme solves the difficult problem of automatic high-precision split charging of the radioactive powder, and effectively ensures the radiation safety of operators.

3. The split charging device has simple and compact structure, and is suitable for being installed and used in a radiation protection hot room with narrow space; and the assembly directly contacted with the radioactive substance has the advantage of easy disassembly and has the advantage of simple replacement and cleaning operation.

Drawings

Fig. 1 is a schematic structural view of a radioactive powder dispensing apparatus. Figure 2 is a schematic view of the dispensing assembly. The device comprises a split charging assembly-1, a driver-2, a weight sensor-3, a split charging hopper-4 and a split charging head-5 right below.

Detailed Description

The following will further describe the automated sub-packaging device for radioactive solid powder according to the present invention with reference to specific embodiments, but the scope of the present invention is not limited thereto.

Example 1

The utility model discloses an automatic partial shipment device of radioactive solid powder, which comprises a controller, a human-computer interface, a bracket, a partial shipment component 1, a driver 2 and a weight sensor 3; the sub-packaging assembly 1 comprises a sub-packaging hopper 4 at the upper side and a sub-packaging head 5 at the right lower side; the driver 2 is arranged at the upper end of the bracket and comprises a rotating motor, a telescopic motor and a transmission lever; the tail end of the transmission rod is meshed and connected with a transmission shaft at the upper part of the sub-assembly 1 through a gear; the screw is connected with the lower part of the transmission shaft, and a stirring paddle is arranged on the screw; the screw rod and the outlet of the subpackaging head 5 are sealed through threads; the weight sensor 3 is arranged on the bracket and is positioned right below the sub-packaging head 5. The controller controls the human-computer interface, the weight sensor and the driver 2 through signals respectively. The material of the distributing hopper 4 is transparent plastic. The depth of the thread groove of the screw is one fourth of the diameter of the screw, and the thread pitch is 4 times of the diameter of the screw. The human-computer interface is provided with a radiation protection protective layer.

The sub-packaging component 1 is a whole, can be conveniently detached and installed, ensures that materials contacted with radioactive powder are conveniently cleaned or discarded in a disposable mode, and meets the requirements of GMP (good manufacturing practice) specifications. The sub-packaging assembly 1 is connected with the driver 2 through gear engagement. The driver transmission rod is vertically arranged, and the sub-packaging opening is vertically downward. In the sub-packaging assembly, there is a paddle that can rotate synchronously with the drive shaft. The weight sensor feeds back a loading signal to the controller (PLC), the controller (PLC) controls the motion frequency of the driver according to the difference value between the actual loading and the loading limit, and when the frequency is close to the subpackaging end point, the frequency is reduced, so that the subpackaging precision and accuracy meet the requirements. In this embodiment, the weighing sensor is a one ten-thousandth balance, and the loading accuracy and precision are shown in the following table through the split charging test:

table 1 adoption the utility model discloses the load accuracy and precision of 10 batches of gained samples

Claims

1. An automatic subpackaging device for radioactive solid powder is characterized by comprising a controller, a human-computer interface, a bracket, a subpackaging assembly (1), a driver (2) and a weight sensor (3); the split charging assembly (1) comprises a split charging hopper (4) at the upper side and a split charging head (5) at the right lower side; the driver (2) is arranged at the upper end of the bracket and comprises a rotating motor, a telescopic motor and a transmission lever; the tail end of the transmission rod is meshed and connected with a transmission shaft at the upper part of the sub-packaging assembly (1) through a gear; the screw is connected with the lower part of the transmission shaft, and a stirring paddle is arranged on the screw; the screw rod and the outlet of the split charging head (5) are sealed by threads; the weight sensor (3) is arranged on the bracket and is positioned right below the sub-packaging head (5); the controller respectively controls the human-computer interface, the weight sensor (3) and the driver (2).

2. The automated packaging unit for radioactive solid powder according to claim 1, wherein the material of the dispensing hopper (4) is selected from one of glass, plastic or aluminum.

3. The automated packaging unit for radioactive solid powder according to claim 1, wherein the material of the dispensing hopper (4) is transparent plastic.

4. An automated radioactive solid powder packaging apparatus according to claim 1, wherein the screw has a groove depth of one fourth of the screw diameter and a pitch of 4 times the screw diameter.

5. An automated radioactive solid powder packaging apparatus according to claim 1, wherein the human-machine interface is provided with a radiation protection shield.