CN114906361A

CN114906361A - Subpackaging equipment with liquid level positioning function, subpackaging method and application thereof

Info

Publication number: CN114906361A
Application number: CN202210647680.0A
Authority: CN
Inventors: 杜泽天; 黄曾�; 田佳乐; 李刚; 郝晋; 杨宇川; 阳国桂
Original assignee: Sichuan Xiantong Atomic Pharmaceutical Technology Co ltd; Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics
Current assignee: Sichuan Xiantong Atomic Pharmaceutical Technology Co ltd; Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics
Priority date: 2022-06-09
Filing date: 2022-06-09
Publication date: 2022-08-16
Anticipated expiration: 2042-06-09
Also published as: CN114906361B

Abstract

A split charging device with liquid level positioning function, a split charging method and application thereof are provided, wherein the split charging device comprises: the loading platform is configured to place a subpackage container, subpackage liquid is pre-filled in the subpackage container, and the liquid level of the subpackage liquid is a first preset distance away from a container opening of the subpackage container; the hopper comprises an accommodating part and a neck part positioned below the accommodating part and communicated with the accommodating part; a funnel disposed below the hopper and configured to be movable in a first direction and/or a second direction, the funnel including an inlet, a funnel handle, and an outlet, an end of the neck portion remote from the receptacle portion being inserted into the funnel from the inlet in response to movement of the funnel in the first direction and/or the second direction, an end of the funnel at which the outlet is located being inserted into the dispensing container; and the position sensor is arranged at the end part where the outlet of the funnel is positioned and is configured to detect the depth of the end surface where the outlet of the funnel is positioned inserted into the subpackaging container, so that the end surface where the outlet of the funnel is positioned is a second preset distance away from the liquid level.

Description

Subpackaging equipment with liquid level positioning function, subpackaging method and application thereof

Technical Field

The disclosure relates to the technical field of radioactive particle subpackage, in particular to subpackage equipment with a liquid level positioning function, a method and application thereof.

Background

The radioactive embolism based on 90Y (yttrium 90) particles is an effective means for treating primary liver cancer at present, can remarkably prolong the life cycle of patients and improve the life quality. For a small number of patients, 90Y particle therapy can degrade tumors, allowing for surgical resection or liver transplantation. Primary liver cancer ranks fifth in the incidence of malignant tumors in the world, ranks third in the mortality of tumors, and more than 60% of patients lose the opportunity to receive radical treatment (hepatectomy, liver transplantation) when liver cancer is diagnosed.

90Y particle is a low toxicity, targeting liver cancer preparation, it is made up of millions of particles carrying radioactivity 90Y, the doctor injects these radioactive particles (diameter is 20-30 μm) into hepatic artery by the method of catheter intervention, the particles are "captured preferentially" to enter the corresponding liver tissue through arterial blood flow, and stay in the peripheral blood vessel of tumor, produce the ray to kill the tumor tissue continuously, make the focus accept the local high-dose radiotherapy and exert some embolism effect, it is minor to non-tumor tissue and other organs at the same time, realize the high-selectivity and high-efficiency killing of liver cancer cell.

The average particle size of 90Y particles is 20-30 mu m, and the split charging operation of the radioactive powder for emitting beta rays needs to be carried out in an operation box with radiation protection, the charging amount is usually 20-500mg, and the split charging precision is required to be within 5%. Even if the radioactive powder is carried out in the operation box for radiation protection, the radioactive powder is required to be prevented from scattering so as to avoid pollution to related equipment in the operation box, and particularly, the radioactive powder is required to be accurately subpackaged in a specified container in the subpackaging process, so that no pollution can be caused. There is no mature solution for how to avoid scattering of radioactive particles in the automatic packaging process.

Disclosure of Invention

Some embodiments of this disclosure provide a partial shipment equipment with liquid level locate function, be applied to the partial shipment of radioactive particle, include:

the loading platform is configured to place a subpackage container, subpackage liquid is pre-filled in the subpackage container, and the distance between the liquid level of the subpackage liquid and the container opening of the subpackage container is a first preset distance;

a hopper comprising a receiving portion and a neck portion below the receiving portion and in communication with the receiving portion, the neck portion being configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to align with the dispensing container;

a funnel disposed below the hopper and configured to be movable in a first direction and/or a second direction, the funnel comprising an inlet, a funnel handle, and an outlet, an end of the neck portion distal from the receptacle portion being inserted into the funnel from the inlet in response to movement of the funnel in the first direction and/or the second direction, an end of the funnel at which the outlet is located being inserted into the dispensing container;

and the position sensor is arranged at the end part where the outlet of the funnel is positioned, and is configured to detect the depth of the end surface where the outlet of the funnel is positioned inserted into the subpackaging container, so that the distance between the end surface where the outlet of the funnel is positioned and the liquid level is a second preset distance.

In some embodiments, the ratio of the second predetermined distance to the first predetermined distance is 30% to 60%.

In some embodiments, the second predetermined distance is proportional to the weight of a single particle of the radioactive particles to be dispensed.

In some embodiments, the carrier includes a weight sensor that weighs the dispensing container in real time to obtain the weight of the radioactive particles loaded into the dispensing container.

In some embodiments, the end surface of the funnel where the outlet is located is inserted into the dispensing container to a depth that decreases as the weight of the radioactive particles loaded into the dispensing container increases, such that the end surface of the funnel where the outlet is located is maintained at the second predetermined distance from the liquid surface.

In some embodiments, further comprising:

and the limiting mechanism is configured to enable the maximum distance between the end face where the outlet of the funnel is located and the container opening of the subpackaging container to be the first preset distance.

In some embodiments, the position sensor comprises one of a laser sensor, an ultrasonic sensor, an image sensor, or a combination thereof.

In some embodiments, further comprising:

a screen disposed in the neck configured to receive the radioactive particles to be dispensed;

the vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate at a preset frequency and/or a preset amplitude in a first direction, and in response to the vibration work of the vibrating device, the radioactive particles penetrate through the screen and are subpackaged into the subpackaging container through an opening of the neck part, which is far away from the accommodating part; in response to deactivation of the vibration device, the screen preventing passage of the radioactive particles through the neck;

wherein the second predetermined distance increases with an increase in the predetermined frequency and/or the predetermined amplitude.

Some embodiments of the present disclosure provide a dispensing method with a liquid level positioning function, which employs the dispensing apparatus described in any of the above embodiments, and the dispensing method includes:

placing the subpackage container filled with the subpackage liquid on the bearing platform;

moving the funnel in a first direction and/or a second direction to insert the neck portion from the opening of the receptacle portion into the funnel from the funnel inlet while inserting the end of the funnel where the outlet is located into the dispensing container;

controlling the depth of the end face of the funnel where the outlet is located inserted into the subpackaging container, so that the end face of the funnel where the outlet is located is a second preset distance away from the liquid level;

and controlling the vibration device to execute vibration work at a preset frequency and/or a preset amplitude until the amount of the radioactive particles in the subpackaging container meets the subpackaging standard.

In some embodiments, the controlling the vibration device to perform the vibration operation at a preset frequency and/or a preset amplitude further includes:

and adjusting the depth of the end face where the outlet of the funnel is inserted into the subpackaging container in real time, so that the end face where the outlet of the funnel is away from the liquid level by a second preset distance.

and adjusting the depth of the end face where the outlet of the funnel is inserted into the subpackaging container in real time, so that the second preset distance is increased along with the increase of the preset frequency and/or the preset amplitude, and the second preset distance is decreased along with the decrease of the preset frequency and/or the preset amplitude.

Some embodiments of the present disclosure also provide a use of a dispensing apparatus for radiopharmaceutical dispensing, the dispensing apparatus comprising a dispensing apparatus as described in any one of the above.

Relative to the related art, the present disclosure has at least the following technical effects:

according to the dispensing equipment with the liquid level positioning function, the position sensor is arranged, so that the end face where the outlet of the funnel is located is inserted into the dispensing container to a second preset distance, and the second preset distance is adjusted according to the vibration frequency and/or the vibration amplitude of the vibration device, so that the distance between the end face where the outlet of the funnel is located and the liquid level is just right, on one hand, the radioactive particles are not located too close to the liquid level to cause the splash substances after falling into the dispensing liquid to pollute or block the outlet of the funnel, on the other hand, the radioactive particles are not located too close to the container opening to scatter outside the dispensing container from the container opening to pollute the box body.

Drawings

In order to more clearly illustrate the embodiments of the present disclosure or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are some embodiments of the present disclosure, and other drawings can be obtained according to the drawings without creative efforts for those skilled in the art.

FIG. 1A is a schematic diagram of a racking system provided in some embodiments of the present disclosure;

fig. 1B is a schematic structural diagram of a radioactive particle dispensing apparatus according to some embodiments of the present disclosure;

FIG. 2 is an enlarged perspective view of area M of FIG. 1B;

FIG. 3 is a flow chart of a racking method provided by an embodiment of the present disclosure;

FIG. 4 is a schematic view of a neck receptacle according to some embodiments of the present disclosure;

fig. 5 is a schematic structural view of a hopper and a hopper provided in some embodiments of the present disclosure;

FIG. 6 is a flow chart of a racking method provided by some embodiments of the present disclosure;

fig. 7 is a schematic side view of a closed state of a barrier according to some embodiments of the present disclosure;

fig. 8 is a schematic top view of a closed position of a barrier according to some embodiments of the present disclosure;

fig. 9 is a schematic top view of a closed position of a barrier according to some embodiments of the present disclosure;

FIG. 10 is a side view schematic of a waste tray provided in some embodiments of the present disclosure;

FIG. 11 is a flow chart of a racking method provided by some embodiments of the present disclosure;

FIG. 12 is a schematic diagram of a control structure of a vibration device according to some embodiments of the present disclosure;

FIG. 13 is a flow chart of a racking method provided by some embodiments of the present disclosure;

figure 14 is a schematic view of a dispensing level positioning structure provided in some embodiments of the present disclosure;

fig. 15 is a flowchart of a racking method provided by some embodiments of the present disclosure.

Detailed Description

To make the objects, technical solutions and advantages of the present disclosure more apparent, the present disclosure will be described in further detail with reference to the accompanying drawings, and it is apparent that the described embodiments are only some embodiments of the present disclosure, not all embodiments. All other embodiments, which can be derived by one of ordinary skill in the art from the embodiments disclosed herein without making any creative effort, shall fall within the scope of protection of the present disclosure.

The terminology used in the embodiments of the present disclosure is for the purpose of describing particular embodiments only and is not intended to be limiting of the disclosure. As used in the disclosed embodiments and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise, and "a plurality" typically includes at least two.

It should be understood that the term "and/or" as used herein is merely one type of association that describes an associated object, meaning that three relationships may exist, e.g., a and/or B may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter related objects are in an "or" relationship.

It is also noted that the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that an article or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such article or apparatus. Without further limitation, the recitation of an element by the phrase "comprising a" does not exclude the presence of additional like elements in a commodity or device comprising the element.

In the medical field, the dispensing of non-radioactive particles, such as non-radioactive powders and granules, is generally performed by a screw dispenser, but such a screw dispenser cannot be directly used for dispensing radioactive powders. There are mainly the following reasons:

1. the split charging amount of the screw split charging machine is usually more than 100mg, and the split charging precision is difficult to ensure for the split charging amount less than 100 mg.

2. Radioactive particles are good in particle size uniformity and good in flowability, and if a screw racking machine is adopted, the problem of leakage of particles in different degrees can exist, so that the loading amount is inaccurate, the radioactive particles are scattered, and the radioactive particles can be broken to influence the medicine quality.

3. The screw rod split charging device does not consider the requirement of ionizing radiation resistance, and a logic circuit and a device are directly exposed in the ionizing radiation environment, so that equipment failure is caused.

4. The screw rod sub-packaging device does not consider the requirement of small total packaging amount of the radioactive medicines, and the device is huge and is not convenient for radiation protection.

In the prior art, the following technical problems still exist for radioactive particle subpackage:

1. the raw material bottle grabbing manipulator overturns, when the radioactive particles are poured into the split charging equipment, the powder may not be poured into the split charging equipment due to inaccurate positioning, but fall to the bottom of the box chamber; or partial particle powder is taken away by airflow due to certain negative pressure in the box chamber;

2. in the particle vibration subpackage process, due to the fact that certain negative pressure exists in the box chamber, partial particle powder is taken away from an opening on the upper side of the subpackage equipment through air flow, and does not flow out from an outlet on the lower side, and box type pollution is caused.

To at least one of the problem in the correlation technique as described above, for satisfying the partial shipment demand of medical radioactive particle, realize the accurate partial shipment to radioactive particle, can avoid the pollution of the radioactive particle of partial shipment in-process simultaneously, this disclosure provides a partial shipment device of radioactive particle, includes: a carrier configured to hold a dispensing container; the hopper is funnel-shaped, comprises an accommodating part and a neck part positioned below the accommodating part and communicated with the accommodating part, and is configured to accommodate radioactive particles to be subpackaged, an opening is formed in the end part, far away from the accommodating part, of the neck part, the opening is configured to be aligned with the subpackaging container, the diameter of the accommodating part is larger than that of a raw material bottle body for accommodating the radioactive particles, and the neck part has enough length to enable the radioactive particles to be subpackaged to be positioned below the joint of the accommodating part and the neck part after the radioactive particles to be subpackaged are poured into the neck part; a screen disposed in the neck; the vibrating device is connected with the hopper, the hopper and the screen mesh are driven to vibrate in the first direction in a configuration mode, the vibrating device stops working in response, the screen mesh prevents the radioactive particles from passing through the neck, the vibrating device works in response, the radioactive particles penetrate through the screen mesh, the neck is far away from an opening of the containing part, the radioactive particles are subpackaged into the subpackaging container, and the radioactive particles loaded into the hopper are subpackaged to the subpackaging container through the screen mesh in a vibrating mode to achieve accurate subpackaging of the radioactive particles.

Alternative embodiments of the present disclosure are described in detail below with reference to the accompanying drawings.

Fig. 1A is a schematic structural diagram of a racking system according to some embodiments of the present disclosure. As shown in fig. 1A, the present disclosure provides a dispensing system 1000 for radioactive particles, such as a radiopharmaceutical or radioactive microspheres, for dispensing a radioactive drug, such as radioactive particles or radioactive powder, from a single large material container into a plurality of small dispensing containers. The racking system 1000 includes a racking station 1, a cap-removing/capping station 3, and a racking container-placing station 2. And (3) performing sub-packaging of the radioactive particles at the sub-packaging station 1, and sub-packaging the radioactive particles into sub-packaging containers. And the cover taking/buckling operation is executed at the cover taking/buckling station 3, specifically, the cover body in the subpackaging container is picked up before subpackaging operation, and the cover body is buckled into the subpackaging container after the subpackaging operation. The subpackage container placing station 2 is used for placing the subpackage containers before and after the subpackage operation, and the subpackage containers move among the three stations to execute the operation of each station.

The dispensing station 1 is provided with a dispensing device for radioactive particles, and fig. 1B is a schematic structural diagram of the dispensing device for radioactive particles according to some embodiments of the present disclosure. As shown in fig. 1B, the dispensing apparatus 100 includes a carrier 10, and the carrier 10 is configured to hold the dispensing container 20. The dispensing container 20 is used for containing the dispensed radioactive particles, including but not limited to radioactive glass particles and radioactive particle resin particles. The dispensing container 20 is, for example, a vial of penicillin. The dispensing device 100 further comprises a hopper 30, the hopper 30 being, for example, funnel-shaped and comprising a containing portion 31 and a neck portion 32 located below the containing portion 31 and communicating with the containing portion 31. The hopper 30 is configured to contain radioactive particles to be dispensed. The end of the neck 32 remote from the receiving portion 31 is provided with an opening configured to align with the dispensing container 20 to dispense the radioactive particles to be dispensed received in the hopper 30 into the dispensing container 20.

Fig. 2 is an enlarged perspective view of the region M in fig. 1B. Referring to fig. 1B and 2, a screen 321 is disposed in the neck 32 of the hopper 30, a plurality of meshes are uniformly distributed on the screen 321, and the apertures of the meshes are slightly larger than the particle size of the radioactive particles contained in the hopper 30, for example, the apertures of the meshes of the screen are 1 to 3 times of the particle size of the radioactive particles. In some embodiments, for example, when the dispensing apparatus 100 is used to dispense radioactive particles, the diameter of the radioactive particles is 20 to 30 μm, and the diameter of the mesh hole of the screen 321 is 22 to 90 μm. The radioactive particles have the same charge, the radioactive particles contained in the hopper 30 are repelled by the charge interaction, and the radioactive particles at the screen 321 will not pass through the screen 321 with similar mesh size to the radioactive particles under the charge interaction.

Referring to fig. 1B, the dispensing apparatus 100 further includes a vibration device 40, wherein the vibration device 40 is connected to the hopper 30 and configured to drive the hopper 30 and the screen 321 to vibrate in a first direction, such as a horizontal direction. Specifically, as shown in fig. 1B, the vibration device 40 includes a driver 41 and a vibration block 42, and the driver 41 is disposed on a holder of the racking device for driving the vibration block 42 to perform a vibration operation. The vibrating mass 42 is coupled to, e.g., snapped into, the hopper 30 and is configured to support the hopper 30. In some embodiments, the vibrating block 42 has a fixing through hole 421, at least a portion of the neck 32 of the hopper 30 passes through the fixing through hole 421 so that the hopper 30 is fixedly supported by the vibrating block 42, and the inner wall of the fixing through hole 421 has a slope with respect to the vertical direction, which matches with the slope of the neck 32 of the hopper 30 with respect to the vertical direction, in which case, the hopper 30 can be conveniently mounted on or dismounted from the vibrating block 42, so as to facilitate replacement of the hopper 30, facilitate cleaning or disposable use of the hopper 30 in direct contact with radioactive particles, and meet GMP (good manufacturing practice) requirements of pharmaceutical production.

When the dispensing of the radioactive particles is performed using the dispensing apparatus 100, the screen 321 prevents the radioactive particles from passing through the neck 32 of the hopper 30 in response to the vibration device 40 being deactivated. In response to the operation of the vibration device 40, the radioactive particles pass through the screen 321 and are dispensed into the dispensing container 20 through the opening of the neck portion 32 away from the receiving portion 31. Specifically, as described above, in the static state of the screen 321 and the hopper 30, since the aperture of the mesh is slightly larger than the radioactive particles contained in the hopper 30, the screen 321 can support the radioactive particles under the effect of the charge carried by the radioactive particles, and the radioactive particles located at the screen 321 will not pass through the screen 321 with the aperture similar to that of the radioactive particles. When the screen 321 and the hopper 30 are vibrated by the vibrating device 40, the balance between the acting force of the electric charge, the gravity of the radioactive particles and the supporting force of the screen 321 on the radioactive particles is broken, and the radioactive particles located on the screen 321 can relatively slowly pass through the meshes of the screen 321 under the action of the gravity and are dispensed into the dispensing container 20 through the opening at the end of the neck 32 away from the accommodating portion 31.

The sub-packaging device adopting the vibration mode can realize accurate control on the sub-packaging of radioactivity, and whether the radioactive particles flow out of the hopper 30 or not is controlled by controlling whether the vibration device 40 works or not. Adopt above-mentioned partial shipment device to carry out the partial shipment to radioactive particle, can satisfy the partial shipment requirement of high accuracy, can realize being less than 5% partial shipment precision to the partial shipment volume of 20 ~ 500 mg.

And adopt above-mentioned partial shipment device can realize sieving when carrying out the partial shipment to radioactive particle, further controlled the particle diameter of granule, detached the large granule impurity in treating the partial shipment granule. The subpackage process can not cause mechanical extrusion to the particles to be subpackaged, does not damage the particles and effectively ensures the product quality.

In other embodiments, the radioactive particles to be dispensed are 20 to 80 μm in diameter, and in this case, the aperture of the screen is, for example, 20 to 200 μm, preferably 30 to 100 μm. Thus, the radioactive particles can not be leaked when the vibration device does not work, and the hopper slowly releases the radioactive particles when the vibration device works.

In some embodiments, the speed and accuracy of dispensing may be affected by the area of the screen. In order to ensure the speed and precision of the split charging of 20-500mg granules, the area of the screen is not more than 10cm ² Preferably not more than 1cm ² 。

In some embodiments, to reduce bremsstrahlung radiation from beta rays emitted by the radioactive particles, the hopper material in contact with the radioactive particles may be selected from one or a combination of glass, plastic, or aluminum, preferably a transparent plastic material. Further, in order to reduce the electrostatic adsorption effect between the transparent plastic material and the radioactive particles and improve the yield of the subpackage, in some embodiments, an aluminum foil layer can be further arranged on the inner wall of the hopper made of the plastic material.

In some embodiments, the hopper 30 and the screen 321 therein are of a unitary design, and after a predetermined number of batches are dispensed, the hopper 30 and the screen 321 therein may be replaced as a unit to meet GMP specifications.

In some embodiments, the carrier 10 includes a sensor that monitors in real time the amount of radioactive particles loaded into the dispensing container 20. The sensor is, for example, a weight sensor or a radioactivity sensor. The sensor is disposed in the carrier 10, and the circuit portion electrically connected to the sensor is also disposed in the carrier 10 and is as far away from the surface of the carrier 10 contacting the dispensing container 20 as possible, so as to avoid the radioactive particles in the dispensing container 20 from adversely affecting the circuit portion. In other embodiments, a radiation protection device may be disposed around the circuit portion to shield radiation from the radioactive particles to ensure proper operation of the circuit portion.

In some embodiments, the sensor is, for example, a weight sensor that weighs the dispensing container in real time to obtain the weight of the radioactive particles loaded into the dispensing container 20. The vibration means 40 is controlled based on the weight of the radioactive particles loaded into the dispensing container 20 obtained in real time, thereby achieving accurate dispensing of the radioactive particles.

In the dispensing apparatus 100 as previously described, the rate at which radioactive particles, such as 90Y radioactive particles, flow from the hopper 30 when the vibratory apparatus 40 is operated is related to the frequency F and amplitude a of vibration of the vibratory apparatus 40. The applicant has found that, with the amplitude a of the vibration device 40 unchanged, the higher the vibration frequency F of the vibration device 40, the greater the rate at which radioactive particles flow out of the hopper 30, and the lower the vibration frequency F of the vibration device 40, the lower the rate at which radioactive particles flow out of the hopper 30. When the vibration frequency F of the vibration device 40 is constant, the larger the amplitude a of the vibration device 40, the higher the rate at which radioactive particles flow out of the hopper 30, and the smaller the amplitude a of the vibration device 40, the higher the rate at which radioactive particles flow out of the hopper 30.

The slow outflow rate of radioactive particles affects the dispensing efficiency, and the fast outflow rate of radioactive particles affects the dispensing accuracy. In order to achieve both the dispensing efficiency and the dispensing accuracy, the inventors performed frequency conversion or variable amplitude control on the vibration device 40 when the dispenser device 100 was used to dispense radioactive particles, thereby achieving better dispensing of the radioactive particles.

In some embodiments, during the dispensing of the radioactive particles by using the dispensing apparatus 100, the precise dispensing of the radioactive particles is achieved by controlling the vibration frequency of the vibration apparatus to decrease as the weight of the radioactive particles loaded into the dispensing container increases.

The inventor obtains a scheme for controlling the vibration frequency of the vibration device to obtain a good subpackaging effect of the radioactive particles through research calculation and a large number of experiments. The method comprises the following specific steps:

the vibration frequency F of the vibration device satisfies the following formula:

wherein, W _D ＝W _S -W _R ，W _S Standard weight, W, of the radioactive particles intended to be filled in the dispensing container _R The weight of the radioactive particles loaded into the dispensing container is measured for the weight sensor.

The following is illustrative of some examples that the inventors have employed in experiments:

in both the following examples and comparative examples, the dispensing apparatus 100 shown in FIG. 1B was used, the 90Y radioactive particles were dispensed, the standard amount was 100mg, and the amplitude A of the vibration apparatus 40 was 300. mu.m.

Example 1

wherein, W _D ＝W _S -W _R ，W _S For the standard weight of the radioactive particles intended to be filled in the dispensing container, W _R The weight of the radioactive particles loaded into the dispensing container is measured for the weight sensor.

Comparative example 1

Comparative example 2

F＝W _D Hz

TABLE 1

As can be seen from table 1, the dispensing time of example 1 and comparative example 1 is shorter than that of comparative example 2, the dispensing accuracy of example 1 is higher than that of comparative example 1 and closer to the standard dispensing amount, the dispensing accuracy of example 1 and comparative example 2 is higher than that of comparative example 1, and the dispensing time of example 1 is shorter. Compared with comparative examples 1 and 2, example 1 can achieve both dispensing time and dispensing accuracy.

In some embodiments, during the dispensing of the radioactive particles by using the dispensing apparatus 100, the amplitude of the vibration device decreases as the weight of the radioactive particles loaded into the dispensing container increases, so as to dispense the radioactive particles.

The inventor has studied and calculated and has obtained a scheme for controlling the amplitude of the vibration device to obtain a good dispensing effect of the radioactive particles through a large number of experiments. The method comprises the following specific steps:

the amplitude A of the vibration device satisfies the following formula:

in both the following examples and comparative examples, the dispensing apparatus 100 shown in FIG. 1B was used, the 90Y radioactive particles were dispensed, the standard amount was 100mg, and the frequency F of the vibration apparatus 40 was 100 Hz.

Example 2

The amplitude A of the vibration device satisfies the following formula:

wherein, W _D ＝W _S -W _R ，W _S For said separate packaging containerStandard weight of the radioactive particles planned to be charged, W _R The weight of the radioactive particles loaded into the dispensing container is measured for the weight sensor.

Comparative example 3

Comparative example 4

The vibration frequency A of the vibration device satisfies the following formula:

A＝5W _D μm

TABLE 2

As can be seen from table 2, the dispensing accuracy of example 2 is greatly different from that of comparative example 3 and that of comparative example 4, but the dispensing time of example 2 is obviously different from that of comparative example 3 and that of comparative example 4. Compared with comparative examples 3 and 4, example 2 can achieve both dispensing time and dispensing accuracy.

In the foregoing embodiment, the sub-packaging is completed by controlling the vibration device 40 to operate until the weight of the radioactive particles in the sub-packaging container 20 meets the requirement based on the real-time monitoring of the weight of the radioactive particles in the sub-packaging container 20, and in other embodiments, the sub-packaging may be completed by controlling the vibration device 40 to operate until the activity of the radioactive particles in the sub-packaging container 20 meets the requirement based on the real-time monitoring of the activity of the radioactive particles in the sub-packaging container 20.

In some embodiments, referring to fig. 1B, the racking device 100 further comprises a funnel 50, the funnel 50 being disposed below the hopper 30 and configured to be movable in a second direction, such as a vertical direction. Funnel 50 includes import and export, and the neck 32 of hopper 30 is kept away from the tip of holding portion 31 certainly the import is inserted in the funnel 50, respond to funnel 50 is kept away from along the second direction hopper 30 removes, the tip at funnel 50's export place is inserted in the partial shipment container 20, respond to funnel 50 is followed the second direction orientation hopper 30 removes, the tip at funnel 50's export place certainly take out in the partial shipment container 20.

Funnel 50 can regard as the transmission path of radioactive particle at the partial shipment in-process, and when adopting partial shipment device 100 to carry out the radioactive particle partial shipment, the neck 32 of hopper 30 is kept away from the tip of holding portion 31 is from the import is inserted in funnel 50, and the tip at the export place of funnel 50 is inserted in the partial shipment container 20, the radioactive particle in the hopper 30 can be via funnel 50 partial shipment to the partial shipment container 20 in, avoids the leakage of radioactive particle when the partial shipment. The bore of the inlet of the funnel 50 needs to be large enough, so that under the conditions that the funnel moves along the second direction and the hopper 30 vibrates under the driving of the vibrating device 40, the inner wall of the funnel 50 is not contacted with the outer wall of the neck 32 of the hopper 30, and the influence on the subpackaging operation of the subpackaging device is avoided.

When the dispensing operation is completed for one of the dispensing containers 20, the vibration device 40 stops vibrating, the funnel 50 moves toward the hopper 30 in the second direction, the end portion where the outlet of the funnel 50 is located is drawn out from the dispensing container 20, the dispensed dispensing container 20 is taken away from the carrying platform 10 by, for example, a robot arm, and enters the next process, and the robot arm picks up another empty dispensing container 20 and places the same on the carrying platform 10. The opening of the dispensing container 20 is aligned with the outlet of the funnel 50, the funnel 50 is moved in a second direction away from the hopper 30, the end of the funnel 50 at which the outlet is located is inserted into the dispensing container 20, and the vibrating device 40 is then activated to perform the next dispensing.

As shown in fig. 1B, the movement of the funnel 50 in the second direction is achieved by a movable arm 60, one end of which is used to support the funnel 50, and the other end is slidably connected to the bracket of the racking device 100 through a guide rail.

In some embodiments, the one end of the movable arm 60 has a fixed through hole through which at least a portion of the funnel 50 passes such that the funnel 50 is fixedly supported by the one end of the movable arm 60, and the inner wall of the fixed through hole has a slope with respect to the vertical direction matching the slope of the outer wall of the funnel 50, in which case the funnel 50 can be easily mounted on or removed from the movable arm 60, facilitating the replacement of the funnel 50, facilitating the cleaning or disposable use of the funnel 50 in direct contact with radioactive particles, meeting the GMP specifications for pharmaceutical manufacturing.

If the funnel 50 movable in the second direction is not used, even if the opening of the end of the neck portion 32 of the hopper 30 away from the accommodating portion 31 is aligned with the sub-packaging container 20, since the opening of the end of the neck portion 32 of the hopper 30 away from the accommodating portion 31 is spaced from the sub-packaging container 20 by a predetermined distance, the radioactive particles may be leaked during sub-packaging, and a portion of the radioactive particles flowing out from the opening of the end of the neck portion 32 of the hopper 30 away from the accommodating portion 31 may not enter the sub-packaging container 20 and may be scattered around the sub-packaging container 20. In order to ensure that the radioactive particles only enter the dispensing container 20 after flowing out from the opening of the end of the neck portion 32 of the hopper 30 away from the accommodating portion 31, the hopper 30 may be designed to be movable in the second direction, and after the end of the neck portion 32 away from the accommodating portion 31 is inserted into the dispensing container 20, the vibration device 40 may be activated to perform dispensing. However, in this way, the hopper 30 needs to be moved frequently to divide the radioactive particles into a plurality of sub-containers 20, and each sub-container needs to be moved to complete the sub-packaging, which may cause the particles in the hopper 30 to be released accidentally due to accidental vibration of the hopper 30 during the moving process, and the sub-packaging accuracy is affected. The above problems are overcome by the dispensing apparatus 100 of figure 1B having the funnel 50 movable in the second direction.

Some embodiments of the present disclosure further provide a method for dispensing radioactive particles, which uses the dispensing apparatus described in the foregoing embodiments, as shown in fig. 3, the method includes:

s301: placing the subpackage container on the bearing platform;

specifically, the dispensing container 20 is placed on the carrier table 10 using, for example, a robot arm.

S303: filling a hopper with the radioactive particles;

specifically, the radioactive particles in the raw material bottle are loaded into the hopper 30, for example, using a robot arm.

S305: and controlling the vibration device to vibrate until the amount of the radioactive particles in the subpackaging container meets the subpackaging standard.

Specifically, the vibration device 40 is controlled to vibrate, for example, the vibration parameters in the foregoing embodiments 1 and 2 are used to control the vibration device 40 to perform the vibration operation, and at least the weight of the radioactive particles in the sub-packaging container 20 is approximately equal to the standard sub-packaging amount, for example, 100 mg.

Further, in the prior art, the following technical problems still exist for radioactive particle subpackaging:

1. when the raw material bottle grabbing manipulator overturns and pours the radioactive particles into the split charging equipment, the powder may not be poured into the split charging equipment but fall to the bottom of the box chamber because of inaccurate positioning; or partial particle powder is taken away by airflow due to certain negative pressure in the box chamber;

To at least one of the problems in the related art as described above, in order to meet the requirement for dispensing medical radioactive particles, achieve accurate dispensing of the radioactive particles, and simultaneously avoid contamination of the radioactive particles during the dispensing process, some embodiments of the present disclosure provide a radioactive particle dispensing apparatus, including: a carrier configured to hold a dispensing container; a hopper including a receiving portion and a neck portion below the receiving portion and in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to align with the dispensing container; the diameter of the accommodating part is larger than that of the bottle body of the raw material bottle for accommodating the radioactive particles, and the neck part has enough length so that after the radioactive particles to be subpackaged are poured into the neck part, the radioactive particles to be subpackaged are positioned below the joint of the accommodating part and the neck part, so that the situation that the radioactive particles fly out of the accommodating part 31 due to negative pressure in the box body to cause pollution to the box body can be avoided; a screen disposed in the neck configured to receive the radioactive particles to be dispensed; and the vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction, so that the radioactive particles pass through the screen and are subpackaged into the subpackaging container through an opening of the neck part, which is far away from the accommodating part. Wherein, the diameter of portion 31 of holding is greater than and holds the diameter of radioactive particle's raw materials bottle body for when the manipulator grab raw materials bottle and with the in-process of the leading-in hopper of radioactive particle in the raw materials bottle, because the diameter of portion 31 of holding is enough big, provide great redundant space, avoided on the one hand because the manipulator does not aim at the hopper and the radioactive particle who causes leaks the risk outward, on the other hand has also avoided the interior negative pressure of box to be in the future the risk of the radioactive particle suction hopper that suddenly leaks. In addition, the neck portion is provided with a sufficient length, for example, an elongated structure, specifically, the length of the neck portion ranges from 30 cm to 50cm, so that after the radioactive particles to be dispensed are poured into the neck portion, the radioactive particles to be dispensed are certainly located below the connection between the accommodating portion and the neck portion (i.e., all enter the neck portion) and are not accumulated in the accommodating portion 31, and the risk of contamination to the box body due to the flying of the radioactive particles out of the accommodating portion 31 caused by the negative pressure in the box body can be further avoided.

In some embodiments, as shown in fig. 2, the neck is generally conical, i.e., has a configuration that is thick at the top and thin at the bottom, so that the upper end of the neck has sufficient space to contain the radioactive particles to be dispensed. Further, it is possible to prevent the radioactive particles from flying out of the accommodating portion 31 due to the negative pressure in the case and causing contamination of the case.

In some embodiments, as shown in fig. 4, the neck 32 further includes a receiving portion 322, and the receiving portion 322 protrudes smoothly along the neck 32, so that the receiving portion 322 has enough space to receive the radioactive particles to be dispensed, and when the radioactive particles enter the neck 32 from the receiving portion 31, the excess radioactive particles will be preferentially accumulated in the receiving portion 322 for storage.

In some embodiments, the receiving portion 322 is a substantially conical structure, wherein an included angle θ between the lower edge of the conical structure and the neck portion is greater than 120 degrees, so as to ensure that the lower edge of the conical structure and the neck portion do not cause the accumulation of radioactive particles after the vibration sub-packaging is completed, and the radioactive particles can easily fall into the screen 321 under the vibration of the vibration device 40. The screen 321 is disposed near the connection between the lower edge of the conical structure and the neck, so as to ensure that the radioactive particles are accumulated in the accommodating portion 322 as much as possible, and the accommodating portion 322 has an outward protruding structure, so that the radioactive particles can be prevented from flying out of the accommodating portion 31 due to negative pressure in the box body, and the box body can be prevented from being polluted.

In some embodiments, referring to fig. 1B and 5, the racking device 100 further comprises a funnel 50, wherein the funnel 50 is disposed below the hopper 30 and is configured to be movable in a first direction and/or a second direction, wherein the first direction may be a horizontal direction and the second direction may be a vertical direction, and the funnel 50 can be aligned with the hopper 30 by the movement of the first direction. Funnel 50 includes import 501 and export 502, and the neck 32 of hopper 30 is kept away from the tip of holding portion 31 certainly in the import is inserted in the funnel 50, respond to funnel 50 is kept away from along the second direction hopper 30 removes, the tip at the export 502 place of funnel 50 inserts in the partial shipment container 20, respond to funnel 50 moves along the second direction hopper 30 removes, the tip at the export 502 place of funnel 50 certainly take out in the partial shipment container 20.

In some embodiments, the inlet 501 has a slope 503, and when the vibration device is not activated, the opening 323 of the neck portion away from the accommodating portion abuts against the slope 503 to prevent the radioactive particles to be dispensed from leaking out of the screen 321, then leaking into the hopper 50 along the opening 323, and leaking into the box body from the hopper outlet 502.

In some embodiments, the opening 323 of the neck portion away from the accommodating portion is also a slope structure, the slope structure has the same slope as the slope 503 of the inlet 501, and when the opening 323 of the neck portion away from the accommodating portion abuts against the slope of the inlet 501, the slope structure of the opening abuts against the slope of the inlet, so as to prevent radioactive particles to be dispensed from leaking into the funnel 50 along the opening 323 and leaking into the box body from the funnel outlet 502 after leaking from the screen 321.

In some embodiments, the neck portion is provided with a cushion 324 at the edge of the opening of the ramp structure away from the receptacle, which cushion abuts the ramp of the inlet 501. The cushion 324 may be such that when the funnel 50 is moved in the first or second direction to the neck opening 323 of the funnel, impact with the neck opening 323 due to mechanical forces may damage the funnel or funnel, or further cause leakage of radioactive particles. Wherein the cushion 324 is made of soft rubber, plastic, etc.

In some embodiments, the screen is disposed on a side of the neck portion near the opening, so that the neck portion above the screen has a sufficient accommodation space. When the screen is arranged below the neck part and the neck part has enough length, the neck part at the upper part of the screen can have enough accommodating space, and the pollution to the box body caused by the flying of radioactive particles from the accommodating part 31 due to the negative pressure in the box body can be avoided.

In some embodiments, the material of the hopper comprises one or a combination of glass, plastic or aluminum, and an aluminum foil layer is arranged on the inner wall of the hopper, so that on one hand, pollution of radioactive particles to the hopper is reduced, and on the other hand, friction force can be reduced, and leakage of the radioactive particles is facilitated.

Some embodiments of the present disclosure provide a method for dispensing radioactive particles, as shown in fig. 6, by using the dispensing apparatus of the foregoing embodiments, the method for dispensing includes the following steps:

step S601: placing the subpackage container on the bearing platform;

step S603: moving the funnel along a first direction and/or a second direction to enable the neck to be far away from the opening of the containing part and abut against the inclined plane;

step S605: filling a hopper with the radioactive particles so that the radioactive particles enter the neck and are carried by a screen;

step S607: moving the funnel along a first direction and/or a second direction, separating the opening of the neck part far away from the accommodating part from the state of abutting against the inclined plane, inserting the end part of the neck part far away from the accommodating part into the funnel from the inlet, and simultaneously inserting the end part of the funnel with the outlet into the subpackaging container;

step S609: controlling the vibrating device to vibrate so that the particles pass through the screen and fall into the dispensing container.

The diameter of the accommodating part is larger than that of the raw material bottle body for accommodating the radioactive particles, so that the radioactive particles are prevented from scattering in the process of pouring the radioactive particles into the accommodating part from the raw material bottle, meanwhile, the neck part has enough length to enable the radioactive particles to be subpackaged to be positioned below the joint of the accommodating part and the neck part after the radioactive particles to be subpackaged are poured into the neck part, and further the radioactive particles are prevented from scattering out of the hopper due to negative pressure in the operation box; and the radioactive particles are prevented from scattering and being out of the hopper due to negative pressure in the operation box by means of further arranging the accommodating part, arranging the screen on one side of the neck close to the opening and the like. Further, in the prior art, the following technical problems still exist for radioactive particle subpackaging:

1. when the vibration split charging is not started, the raw material bottle grabbing mechanical arm turns over, when the radioactive particles are poured into the split charging hopper, a small amount of powder is scattered to the box body from the screen at the bottom of the hopper because the screen holes are larger than the particle size of the powder;

2. in the radioactive particle subpackaging process, when one penicillin bottle is subpackaged to the next penicillin bottle is not prepared, due to the accidental vibration of the environment, powder is scattered on the table top of the equipment from the screen at the bottom of the hopper.

To at least one of the problems in the related art as described above, in order to meet the requirement for dispensing medical radioactive particles, achieve accurate dispensing of the radioactive particles, and simultaneously avoid contamination of the radioactive particles before and after dispensing, some embodiments of the present disclosure provide a device for dispensing radioactive particles, and the same structure has the same technical effect, which is not described herein again, and refer to the description of the above embodiments, which specifically includes: a carrier configured to hold a dispensing container; a hopper including a receiving portion and a neck portion below the receiving portion and in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to align with the dispensing container; a screen disposed in the neck configured to receive the radioactive particles to be dispensed; a baffle disposed below the screen of the neck, configured to have an open state and a closed state, for blocking the missing radioactive particles when the baffle is in the closed state, the radioactive particles falling along the neck when the baffle is in the open state; the vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction; wherein, in response to the vibrating device ceasing to operate, the screen prevents the radioactive particles from passing through the neck, and the blocker closes to block the radioactive particles missing from the screen, and in response to the vibrating device operating, the blocker opens and the radioactive particles pass through the screen, are dispensed into the dispensing container through an opening of the neck remote from the receptacle. The opening and closing of the barrier are synchronously controlled by a control signal of the vibration device, namely, the barrier is opened before the vibration of the vibration device starts, and the barrier is closed after the vibration of the vibration device is finished.

In some embodiments, the blocker 325 may include a plurality of portions that are pivotably openable and closable, such as two portions, three portions, four portions, and the like, without limitation. A plurality of rotatable open closed parts form a sealed whole when closed for avoid the radioactive particle scattering of omission, when opening, can be normal carry out the partial shipment to radioactive particle.

In some embodiments, as shown in fig. 7, blocker 325 includes a rotatable first blocker 3251 and a rotatable second blocker 3252, first blocker 3251 and second blocker 3252 are sealingly abutted end to end with blocker 325 in a closed state when first blocker 3251 and second blocker 3252 are rotated to a closed position; when first blocker 3251 and second blocker 3252 rotate to an open position, first blocker 3251 and second blocker 3252 extend down the neck 32 and blocker 325 is in an open state. The rotatable first blocking device 3251 and the rotatable second blocking device 3252 can be rotated without being limited to be controlled by the micro spindle 3254, a rotating gear (not shown), and a motor (not shown), which are not described in detail herein.

In some embodiments, as shown in fig. 8-9, first blocker 3251 and second blocker 3252 are planar or arc-shaped, wherein when first blocker 3251 and second blocker 3252 are planar, a cross section of neck 32 at front and rear ends forms a split circle after first blocker 3251 and second blocker 3252 are closed. When first blocker 3251 and second blocker 3252 are both arc-shaped, a cross section of neck 32 at front and back ends, for example, forms a portion of a split hemisphere or sphere when first blocker 3251 and second blocker 3252 are closed.

In some embodiments, the first barrier 3251 and the second barrier 3252 are arc-surface shaped, and the arcs of the first barrier 3251 and the second barrier 3252 are the same as the arc of the neck at the positions, so that when the first barrier 3251 and the second barrier 3252 rotate to the open position, the first barrier 3251 and the second barrier 3252 are attached to the inner wall of the neck and extend downward, and after the first barrier 3251 and the second barrier 3252 are attached to the inner wall of the neck, the falling space of the radioactive particles can be formed to the maximum extent, and the radioactive particles are prevented from being attached to the surface of the barriers.

In some embodiments, first blocker 3251 and second blocker 3252 are asymmetric structures that when rotated into a closed position, the closed position is off-axis of the neck. When the first barrier 3251 and the second barrier 3252 are asymmetric, once the first barrier 3251 and the second barrier 3252 are not completely and hermetically abutted, the large-area first barrier 3251 can still receive the missing radioactive particles, and particularly, when the first barrier 3251 and the second barrier 3252 are both arc-shaped, the large-area first barrier 3251 alone forms a concave receiving portion, which can effectively receive the missing radioactive particles.

In some embodiments, the ends of first blocker 3251 and second blocker 3252 that sealingly interface are each provided with a flexible portion 3253. In some embodiments, the flexible portion comprises any one or combination of a brush, an elastic rubber, a fabric. The flexible portion 3253 can prevent a sufficient redundant space from being left when the first barrier 3251 and the second barrier 3252 are in interference contact or are not in contact in place due to thermal expansion and cold contraction, and meanwhile, prevent the first barrier 3251 and the second barrier 3252 which are hard from being in contact with each other to cause damage to the barriers.

In some embodiments, the funnel further comprises a solenoid valve disposed above the outlet, the solenoid valve being closed to prevent the omission of the radioactive particles. The solenoid valve can be through controller unified control, when the partial shipment that begins, opens the solenoid valve, and the partial shipment is accomplished the back, closes the solenoid valve to prevent the omission of radioactive particle.

In some embodiments, as shown in fig. 10, the racking device further comprises: a waste tray 70, disposed on the platform, for holding the dispensing containers and receiving the missing radioactive particles. In some embodiments the waste tray includes a recess 71 for receiving the dispensing container. In the particle subpackaging process, when radioactive powder is scattered from the bottom of the funnel due to accidental vibration of the environment in the state that the penicillin bottle is not arranged below the subpackaging funnel, the radioactive powder can be received through the waste tray 70. The waste tray 70 may be a disposable and replaceable device or a reusable device.

Some embodiments of the present disclosure provide a method for dispensing radioactive particles, using a dispensing apparatus according to any of the embodiments described above, the method comprising the following method steps:

step S1101: placing a waste tray on the bearing table;

step S1103: placing the subpackage containers in the grooves of the waste material tray;

step S1105: moving the funnel in a first direction and/or a second direction to insert the neck portion from the opening of the receptacle portion into the funnel from the funnel inlet while inserting the end of the funnel where the outlet is located into the dispensing container;

step S1107: opening the blocker to rotate from a closed state to an open state;

step S1109: controlling the vibration device to vibrate until the amount of the radioactive particles in the subpackaging container meets the subpackaging standard.

The radioactive particle subpackaging device provided by the embodiment of the disclosure avoids omission of radioactive particles after subpackaging is finished by additionally arranging the blocking device, specifically, the blocking device is arranged below the screen of the neck of the hopper, and the blocking device is controlled to be in an opening state and a closing state and can respond to stop working of the vibrating device, the screen prevents the radioactive particles from passing through the neck, the blocking device is closed to be followed by blocking, the radioactive particles are omitted by the screen, response is carried out on the vibrating device, the blocking device is opened, and the radioactive particles pass through the screen, the neck is kept away from the opening subpackaging of the containing part to the subpackaging container. In addition, by the technical means of arranging the waste material tray, arranging the electromagnetic valve in the hopper and the like, the omission of radioactive particles after the split charging is further avoided.

1. in the vibration subpackaging process, under the condition that particles still exist in the funnel, the particles cannot be released due to the failure of the vibrator;

2. after the vibration partial shipment finishes, still can leave over the radioactive particle in the partial shipment route such as funnel, in the partial shipment equipment transportation, because the vibration can lead to the leakage of reflective granule, form the pollution to the box.

To address at least one of the above-mentioned problems in the related art, in order to meet the requirement for dispensing radioactive particles for medical use, achieve accurate dispensing of the radioactive particles, and avoid contamination of the radioactive particles after dispensing, some embodiments of the present disclosure provide a self-cleaning dispensing apparatus for radioactive particles, including: a carrier configured to hold a dispensing container; a hopper comprising a receiving portion and a neck portion below the receiving portion and in communication with the receiving portion, the neck portion being configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to align with the dispensing container; a screen disposed in the neck configured to receive the radioactive particles to be dispensed; the main vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction; the auxiliary vibration device is connected with the hopper and is configured to drive the hopper and the screen to vibrate in a first direction; wherein, in response to the vibrating operation of the primary vibrating means and/or the secondary vibrating means, the radioactive particles are dispensed into the dispensing container through the opening of the neck portion remote from the receiving portion, passing through the screen; the screen prevents passage of the radioactive particles through the neck in response to deactivation of the primary and secondary vibratory devices.

In some embodiments, as shown in fig. 12, the racking device further comprises: the control device is configured to control the main vibration device and the auxiliary vibration device to simultaneously execute vibration work so as to drive the hopper and the screen to vibrate in a first direction; at the moment, the control device distributes balanced driving current to the vibration device and the auxiliary vibration device, so that the vibration device and the auxiliary vibration device vibrate in a coordinated mode with the same frequency and the same amplitude.

In some embodiments, the control device may be further configured to first control the main vibrating device to perform a vibrating operation, and when the main vibrating device drives the hopper and the screen to vibrate in the first direction, the auxiliary vibrating device vibrates along with the main vibrating device; when the main vibration device breaks down, the auxiliary vibration device is controlled to drive the hopper and the screen to vibrate in the first direction, and the main vibration device vibrates along with the auxiliary vibration device. The vibrating device adopts the redundancy design, and after the main vibrating device became invalid, steerable auxiliary vibrating device drive hopper continued the partial shipment, had avoided single vibrating device to become invalid after, had left over the radioactive particle in addition among the partial shipment equipment such as hopper, caused the radioactive particle extravagant on the one hand, on the other hand also prevented that these radioactive particles who leave over from in the middle of the later stage vibration, leaked in the box, caused the pollution of box. The following refers to passive movement, that is, the control device does not provide active driving force to make the control device vibrate, and does not provide active back-driving force to prevent the control device from vibrating, but does not provide any driving external force to the following driving device, so that the following driving device only vibrates by means of the vibration device with the driving external force.

In some embodiments, as shown in fig. 12, the dispensing apparatus further includes an alarm device configured to send an alarm signal to the control device when the main vibrating device fails, and the control device controls the auxiliary vibrating device to drive the hopper and the screen to vibrate in the first direction according to the alarm signal, and controls the main vibrating device to vibrate along with the auxiliary vibrating device.

In some embodiments, the carrier includes a weight sensor that weighs the dispensing container in real time to obtain the weight of the radioactive particles loaded into the dispensing container. The primary and/or secondary vibrating means vibrates at a first vibration frequency when performing a vibratory dispensing operation, the first vibration frequency decreasing as the weight of the radioactive particles contained in the dispensing container increases. The control of the vibration frequency in the normal split charging process of the main vibration device and the auxiliary vibration device and the technical effects thereof are as described in the foregoing embodiments, and are not described herein again.

In some embodiments, the first vibration frequency F of the primary and/or secondary vibration device satisfies the following formula:

In some embodiments, the primary vibration device and/or the secondary vibration device vibrates at a second vibration frequency when the sub-packaging operation is stopped, wherein the second vibration frequency range is 180-300 Hz. The applicant finds that under the normal frequency vibration, the vibration device can ensure accurate sub-packaging of radioactive particles, but after the sub-packaging is finished, a small amount of radioactive particles still remain on the side wall of the neck of the hopper, the accommodating part 322, the screen 321, even the opening 323 of the accommodating part and other positions, and after the sub-packaging is finished, the residual radioactive particles are left in the box body in the later transportation process due to the existence of the residual radioactive particles, so that the box body is polluted. Therefore, when the main vibration device and/or the auxiliary vibration device stops the sub-packaging operation, the vibration frequency needs to be temporarily increased to shake off the residual radioactive particles to the waste tray, so as to avoid the pollution of the box body. The applicant has found through experiments that the increased frequency is preferably about 3 times of the previous vibration frequency, for example, the vibration frequency range is 180-300 Hz.

In some embodiments, the primary and/or secondary vibratory apparatus vibrates at a first amplitude when performing vibratory dispensing operations, the first amplitude decreasing with increasing weight of the radioactive particles contained in the dispensing container. The control of the vibration amplitude and the technical effects thereof in the normal split charging process of the main vibration device and the auxiliary vibration device are as described in the foregoing embodiments, and are not described herein again.

In some embodiments, the first amplitude a of the primary and/or secondary vibrating devices satisfies the following equation:

In some embodiments, the primary vibrating device and/or the secondary vibrating device vibrates with a second amplitude when the dispensing operation is stopped, and the vibration range of the second amplitude is 1000-. As described above, the applicant found that, under the normal vibration amplitude, the vibration device can ensure the accurate dispensing of the radioactive particles, but after the dispensing is completed, a small amount of radioactive particles still remain on the sidewall of the hopper neck, the receiving portion 322, the screen 321, or even the opening 323 far away from the receiving portion, and after the dispensing is completed, the residual radioactive particles are left in the box body during the later transportation process, thereby causing the pollution of the box body. Therefore, when the main vibration device and/or the auxiliary vibration device stops the sub-packaging operation, the vibration amplitude needs to be temporarily increased so as to shake off the residual radioactive particles to the waste tray, thereby avoiding the box body pollution. The applicant has found through experiments that the increased amplitude is preferably about 3 times of the previous vibration frequency, for example, the vibration range of the amplitude is 1000-.

In some embodiments, the sub-packaging device further comprises a waste tray 70 disposed on the carrying platform, and when the sub-packaging is finished, the radioactive particles scattered by the secondary vibration of the main and auxiliary vibrating devices are received by the waste tray 70, so as to avoid pollution caused by scattering on other devices of the box body.

Some embodiments of the present disclosure provide a self-cleaning dispensing method for radioactive particles, which employs the dispensing device according to any of the embodiments, and the dispensing method includes the following steps:

step S1301: placing the subpackage container on the bearing table;

step S1303: moving the funnel in a first direction and/or a second direction to insert the neck portion from the opening of the receptacle portion into the funnel from the funnel inlet while inserting the end of the funnel where the outlet is located into the dispensing container;

step S1305: and controlling the main vibration device and/or the auxiliary vibration device to perform vibration work at a first frequency and/or a first amplitude until the amount of the radioactive particles in the subpackaging container meets the subpackaging standard.

In some embodiments, further comprising:

step S1307: and when the main vibration device and/or the auxiliary vibration device stops subpackaging work, controlling the main vibration device and/or the auxiliary vibration device to execute vibration work at a second frequency and/or a second amplitude.

According to the radioactive particle self-cleaning split charging device provided by the embodiment of the disclosure, the main vibration device and the auxiliary vibration device are arranged, so that the main vibration device and the auxiliary vibration device simultaneously execute vibration work, and the driving power of each vibration device is reduced; or firstly controlling the main vibration device to execute vibration work, wherein the auxiliary vibration device vibrates along with the main vibration device; when the main vibration device breaks down, the auxiliary vibration device is controlled to drive the hopper and the screen to vibrate in a first direction, and the main vibration device vibrates along with the auxiliary vibration device; the risk that the subpackaging work stops and radioactive particles leak out due to the fact that one vibrating device breaks down is avoided; in addition, when the subpackaging work is finished, the vibration frequency or amplitude of the main vibration device and/or the auxiliary vibration device is increased, so that the subpackaging hopper and the like are automatically cleaned, and the leakage of radioactive particles is further avoided.

in the split charging process, the split charging funnel needs to descend below the port of the split charging container and above the liquid level in the split charging container, but the funnel descends too low due to the fact that the descending height of the funnel cannot be accurately controlled, and the funnel enters the position below the liquid level, so that split charging cannot be carried out. Or the falling height of the funnel is not enough, so that the funnel opening is above the opening of the split charging container, particles are left outside the split charging container in the split charging process, and the box body is polluted.

To at least one of the problems in the related art as described above, in order to meet the subpackage requirement of medical radioactive particles, realize the accurate subpackage of the radioactive particles, and simultaneously avoid the contamination of the radioactive particles during the subpackage process, some embodiments of the present disclosure provide a subpackage equipment with a liquid level positioning function, which is applied to the subpackage of the radioactive particles, and includes: a loading platform configured to place a dispensing container, wherein a dispensing liquid is pre-filled in the dispensing container, and a liquid level of the dispensing liquid is a first preset distance H1 from a container opening of the dispensing container, as shown in fig. 14; a hopper including a receiving portion and a neck portion below the receiving portion and in communication with the receiving portion, the neck portion configured to receive radioactive particles to be dispensed, an end of the neck portion remote from the receiving portion being provided with an opening configured to align with the dispensing container; a funnel disposed below the hopper and configured to be movable in a first direction and/or a second direction, the funnel comprising an inlet 501, a funnel handle 504 and an outlet 502, an end of the neck portion remote from the receptacle being inserted into the funnel from the inlet in response to movement of the funnel in the first direction and/or the second direction, an end of the funnel at which the outlet is located being inserted into the dispensing container; and a position sensor 505 disposed at an end of the funnel where the outlet is located, and configured to detect a depth of insertion of an end surface of the funnel where the outlet is located into the dispensing container such that the end surface of the funnel where the outlet is located is a second predetermined distance H2 from the liquid surface.

As a specific example, the subpackaging container is generally a penicillin bottle, the height of the penicillin bottle is about 3-5cm, the diameter of the penicillin bottle is about 0.8-1.5cm, the liquid level height before subpackaging is generally 1-4.5cm, and the distance between the end face where the outlet of the funnel is located and the liquid level height is generally 0.3-1.8 cm. The data is not particularly limited, and is determined by the parameters of the actual dispensing container.

In some embodiments, the ratio of the second preset distance H2 to the first preset distance H1 is 30% -60%. The applicant has found that when the ratio of the second preset distance H2 to the first preset distance H1 is 30% to 60%, it can be ensured that the radioactive particles falling from the dispensing funnel fall into the liquid surface during the dispensing process, and then do not splash the liquid or the jelly of the powder and the liquid, and cause the blockage of the funnel outlet; and the funnel opening is not too close to the opening of the split charging container, so that particles are scattered outside the split charging container in the split charging process, and the box body is not polluted. When the ratio of the second preset distance to the first preset distance is more than 60%, due to the problems of vibration or negative pressure in the box body, the risk of radioactive particles overflowing can occur, and when the ratio of the second preset distance to the first preset distance is less than 30%, liquid can be splashed at the moment of entering the liquid when the weight of the radioactive particles is large enough, so that the pollution of a funnel opening is caused; when the weight of the radioactive particles is not large enough, due to the tension of the liquid surface, a pile is formed between the funnel opening and the liquid surface in a short time, causing contamination of the funnel opening.

In some embodiments, the second predetermined distance H2 is proportional to the single particle weight of the radioactive particles to be packed. The larger the weight is, the more liquid is splashed when the radioactive particles fall into the liquid surface, the larger the height of the liquid is splashed, and the weight of the radioactive particles is usually 20-500mg, so that different distances from the funnel opening to the liquid surface can be preset for subpackaging the radioactive particles with different weights.

In some embodiments, the carrier includes a weight sensor that weighs the dispensing container in real time to obtain the weight of the radioactive particles loaded into the dispensing container. The end surface of the funnel where the outlet is located is inserted into the dispensing container to a depth which decreases with the increase in the weight of the radioactive particles loaded into the dispensing container, so that the end surface of the funnel where the outlet is located is kept at the second preset distance H2 from the liquid surface. In order not to cause the above-mentioned problems, the second predetermined distance H2 must be maintained, and therefore, the funnel can be controlled to move upward by the stepping motor, so that the end surface of the funnel where the outlet is located is kept at the second predetermined distance H2 from the liquid surface.

In some embodiments, the dispensing apparatus further comprises a limiting mechanism configured to make the maximum distance from the end surface where the outlet of the funnel is located to the container opening of the dispensing container be the first preset distance H1, that is, to ensure that the funnel does not insert below the dispensing liquid level, otherwise, the dispensing cannot be realized due to the air pressure. The limiting mechanism is controlled by the stepping motor, and after the type of the radioactive particles to be subpackaged is determined, the subpackaging container and the liquid capacity preassembled in the subpackaging container can be determined, so that the control device can set a maximum descending depth for the funnel in initial control, and once the maximum descending depth is reached, the limiting mechanism controls the stepping motor to stop driving, and the funnel is prevented from being inserted below the subpackaging liquid level. The activation of the limit mechanism is typically caused by an inaccurate measured distance due to a position sensor failure.

In some embodiments, the position sensor 505 comprises one of a laser sensor, an ultrasonic sensor, an image sensor, or a combination thereof. The position sensor is pre-positioned at a location above the funnel outlet, for example, the position sensor is pre-positioned at a location 2-3cm above the funnel outlet, such that the sensor does not enter the dispensing container and does not get stuck in the mouth of the dispensing container. The laser sensor measures the height of the liquid level by measuring the reflection of the liquid level to a light signal, and the ultrasonic sensor measures the height of the liquid level by emitting sound waves to the liquid level.

In some embodiments, the racking apparatus further comprises: a screen disposed in the neck configured to receive the radioactive particles to be dispensed; the vibrating device is connected with the hopper and is configured to drive the hopper and the screen to vibrate at a preset frequency and/or a preset amplitude in a first direction, and in response to the vibration work of the vibrating device, the radioactive particles penetrate through the screen and are subpackaged into the subpackaging container through an opening of the neck part, which is far away from the accommodating part; in response to deactivation of the vibration device, the screen preventing passage of the radioactive particles through the neck; wherein the second predetermined distance increases with an increase in the predetermined frequency and/or the predetermined amplitude. When the vibration frequency or amplitude of the vibration device is increased, the descending speed of the radioactive particles to be packed is increased, that is, the packing speed is increased, and at this time, the distance from the funnel opening to the liquid surface needs to be increased to prevent the funnel opening from being polluted due to splashing of the liquid surface or accumulation of the radioactive particles.

Some embodiments of the present disclosure provide a dispensing method with a liquid level positioning function, which employs the dispensing apparatus described in any of the above embodiments, as shown in fig. 15, and includes the following method steps:

step S1501: placing the subpackage container filled with the subpackage liquid on the bearing platform;

step S1503: moving the funnel in a first direction and/or a second direction to insert the neck portion from the opening of the receptacle portion into the funnel from the funnel inlet while inserting the end of the funnel where the outlet is located into the dispensing container;

step S1505: controlling the depth of the end face of the funnel where the outlet is located inserted into the subpackaging container, so that the end face of the funnel where the outlet is located is a second preset distance away from the liquid level;

step S1507: and controlling the vibration device to execute vibration work at a preset frequency and/or a preset amplitude until the amount of the radioactive particles in the subpackaging container meets the subpackaging standard.

In some embodiments, the controlling the vibration device to perform the vibration operation at a preset frequency and/or a preset amplitude further comprises: and adjusting the depth of the end face where the outlet of the funnel is inserted into the subpackaging container in real time, so that the end face where the outlet of the funnel is away from the liquid level by a second preset distance.

In some embodiments, the controlling the vibration device to perform the vibration operation at a preset frequency and/or a preset amplitude further includes: and adjusting the depth of the end face where the outlet of the funnel is inserted into the subpackaging container in real time, so that the second preset distance is increased along with the increase of the preset frequency and/or the preset amplitude, and the second preset distance is decreased along with the decrease of the preset frequency and/or the preset amplitude.

According to the split charging equipment with the liquid level positioning function, the position sensor is arranged, the end face where the outlet of the funnel is located is enabled to detect the depth of the end face inserted into the split charging container, the end face where the outlet of the funnel is located is enabled to be at the second preset distance from the liquid level, the second preset distance is adjusted according to the vibration frequency and/or the vibration amplitude of the vibration device, the distance from the end face where the outlet of the funnel is located to the liquid level is enabled to be proper, on one hand, the radioactive particles cannot fall into the split charging liquid and splash up due to the fact that the radioactive particles are too close to the liquid level to pollute the liquid level or block the outlet of the funnel, on the other hand, the radioactive particles cannot be too close to the container opening, and the radioactive particles can scatter out of the split charging container from the container opening to pollute a box body.

The flowchart and block diagrams in the figures illustrate the architecture, functionality, and operation of possible implementations of systems, methods and computer program products according to various embodiments of the present disclosure. In this regard, each block in the flowchart or block diagrams may represent a module, segment, or portion of code, which comprises one or more executable instructions for implementing the specified logical function(s). It should also be noted that, in some alternative implementations, the functions noted in the block may occur out of the order noted in the figures. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality involved. It will also be noted that each block of the block diagrams and/or flowchart illustration, and combinations of blocks in the block diagrams and/or flowchart illustration, can be implemented by special purpose hardware-based systems which perform the specified functions or acts, or combinations of special purpose hardware and computer instructions.

Finally, it should be noted that: the embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The system or the device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.

The above examples are only intended to illustrate the technical solutions of the present disclosure, not to limit them; although the present disclosure has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present disclosure.

Claims

1. The utility model provides a partial shipment equipment with liquid level locate function, is applied to radioactive particle partial shipment which characterized in that includes:

2. The racking device of claim 1 wherein the ratio of said second predetermined distance to said first predetermined distance is between 30% and 60%.

3. A dispensing apparatus as claimed in claim 2 wherein the second predetermined distance is directly proportional to the weight of a single particle of radioactive particles to be dispensed.

4. The dispensing apparatus of claim 1 wherein the carrier includes a weight sensor that weighs the dispensing container in real time to obtain the weight of the radioactive particles loaded into the dispensing container.

5. The dispensing apparatus of claim 4 wherein the end surface of the funnel at which the outlet is located decreases in depth into the dispensing container as the weight of the radioactive particles loaded into the dispensing container increases such that the end surface of the funnel at which the outlet is located is maintained at the second predetermined distance from the liquid surface.

6. The racking device of claim 1 further comprising:

7. The racking apparatus of claim 1 wherein said position sensor comprises one or a combination of a laser sensor, an ultrasonic sensor, an image sensor.

8. The racking device of claim 1 further comprising:

9. A sub-packaging method having a liquid level positioning function, which employs the sub-packaging apparatus according to any one of claims 1 to 8, the sub-packaging method comprising:

10. The racking method according to claim 9, wherein said controlling said vibrating means to perform a vibrating operation at a preset frequency and/or a preset amplitude, further comprising thereafter:

11. The racking method according to claim 9, wherein said controlling said vibrating means to perform a vibrating operation at a preset frequency and/or a preset amplitude, further comprising thereafter:

12. Use of a dispensing apparatus for radiopharmaceutical dispensing, the dispensing apparatus comprising a dispensing apparatus as claimed in any one of claims 1 to 8.