CN211848006U

CN211848006U - Fluorescence immunity magnetic adsorption device

Info

Publication number: CN211848006U
Application number: CN201921937976.6U
Authority: CN
Inventors: 林华青; 李俊玲; 黄晓雨
Original assignee: Zhuhai Dl Medical Biotech Co ltd
Current assignee: Zhuhai deer Bioengineering Co.,Ltd.
Priority date: 2019-11-08
Filing date: 2019-11-08
Publication date: 2020-11-03
Anticipated expiration: 2029-11-08

Abstract

The utility model discloses a fluorescence immunity magnetism adsorption equipment, including collecting pipe and magnetic component. A transition section is arranged between the side wall of the collecting pipe and the bottom wall of the collecting pipe, and the inner wall of the transition section is arc-shaped; the magnetic assembly is provided with at least two magnetic blocks, all the magnetic blocks are arranged side by side, the polarity directions of all the magnetic blocks are the same, the surfaces of all the magnetic blocks facing the collecting pipe are positioned on the same plane, the tangent lines of any point of the inner walls of the plane and the transition section are mutually parallel, and all the magnetic blocks can be abutted against the outer wall of the transition section. When the magnetic blocks and the transition section are close to and abutted against each other, the magnetic forces of at least two magnetic blocks are crossed and superposed, so that the mixture of the magnetic beads and the nucleic acid is subjected to larger magnetic force, the magnetic adsorption effect is good, the magnetic adsorption time can be effectively shortened, and the working efficiency is improved; and the mixture of the magnetic beads and the nucleic acid is concentrated in the transition section, so that the loss of the nucleic acid is reduced in the steps of removing waste liquid and washing, and the accuracy of subsequent nucleic acid concentration detection is improved.

Description

Fluorescence immunity magnetic adsorption device

Technical Field

The utility model relates to a biological detection technical field that draws, in particular to fluorescence immunity magnetism adsorbs device.

Background

The fluorescence immunoassay analyzer, the nucleic acid extractor and other equipment are provided with magnetic adsorption devices for extracting nucleic acid, the nucleic acid extraction can be used for separating nucleic acid components from cells, and the nucleic acid extraction has important significance in various fields of disease control centers, clinical disease diagnosis, blood transfusion safety, forensic medicine identification, environmental microorganism detection, food safety detection, animal husbandry, molecular biology research and the like. The fluorescence immunoassay analyzer extracts nucleic acid by using a magnetic adsorption method, then adds a fluorescent agent into the nucleic acid, and analyzes the concentration of the nucleic acid by measuring fluorescence.

SUMMERY OF THE UTILITY MODEL

The utility model discloses aim at solving one of the technical problem that exists among the prior art at least. Therefore, the utility model provides a fluorescence immunity magnetism adsorbs device can reduce the loss of nucleic acid, improves the efficiency of drawing.

According to the utility model discloses fluorescence immunity magnetism adsorption equipment, including collecting pipe and magnetic component. A transition section is arranged between the side wall of the collecting pipe and the bottom wall of the collecting pipe, and the inner wall of the transition section is arc-shaped; the magnetic assembly is provided with at least two magnetic blocks, all the magnetic blocks are arranged side by side, the polarity directions of all the magnetic blocks are the same, all the magnetic blocks face the surface of the collecting pipe and are positioned on the same plane, the plane and a tangent line of any point of the inner wall of the transition section are parallel to each other, and all the magnetic blocks can be abutted to the outer wall of the transition section.

According to the utility model discloses fluorescence immunity magnetism adsorbs device has following beneficial effect at least:

the magnetic blocks are close to and abutted against the transition section, and the magnetic forces of at least two magnetic blocks are crossed and superposed, so that the mixture of the magnetic beads and the nucleic acid is subjected to larger magnetic force, the magnetic adsorption effect is good, the magnetic adsorption time can be effectively shortened, and the working efficiency is improved; and the plane of the surface of the magnetic block facing the collecting pipe and the tangent line of any point of the inner wall of the transition section are parallel to each other, and the mixture of the magnetic beads and the nucleic acids is concentrated in the transition section, so that the loss of the nucleic acids is reduced in the steps of removing waste liquid and washing, and the accuracy of subsequent nucleic acid concentration detection is improved.

According to some embodiments of the utility model, still include bottom plate and first drive arrangement, the collecting pipe pass through horizontal glide machanism install in on the bottom plate, first drive arrangement with the collecting pipe is connected.

According to some embodiments of the utility model, be equipped with the tray on the horizontal slip mechanism, slidable mounting has the reagent board on the tray, the collecting pipe place in on the reagent board, first drive arrangement with the tray is connected.

According to some embodiments of the present invention, the first driving device comprises a first motor disposed on the bottom plate, a first lead screw connected to the output end of the first motor, and a first lead screw nut disposed on the first lead screw, the first lead screw nut and the tray being connected.

According to some embodiments of the utility model, be equipped with the spout on the tray, be equipped with the slider on the reagent board, the spout with the slider can mutually support and connect.

According to the utility model discloses a some embodiments, the bottom plate is in be equipped with lift drive on the region of horizontal glide machanism one end, the magnetic component still includes the mounting panel, all the magnetic path is all located on the same surface of mounting panel, the mounting panel with lift drive's output is connected.

According to some embodiments of the utility model, the mounting panel is located through vertical glide machanism on the bottom plate, lift drive is including locating second motor on the bottom plate, connecting the second lead screw of second motor output with locate second lead screw nut on the second lead screw, second lead screw nut with the mounting panel is connected.

According to some embodiments of the invention, the cross-section of the collection tube is annular.

Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.

Drawings

The above and/or additional aspects and advantages of the present invention will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:

FIG. 1 is a schematic view of an immunofluorescent magnetic adsorption apparatus according to an embodiment of the present invention;

fig. 2 is a schematic cross-sectional view of a fluorescence immunoassay magnetic adsorption device according to an embodiment of the present invention;

fig. 3 is a schematic view of the magnetic assembly, the vertical sliding mechanism and the lifting driving device according to the embodiment of the present invention.

Detailed Description

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present invention, and should not be construed as limiting the present invention.

In the description of the present invention, it should be understood that the orientation or positional relationship indicated with respect to the orientation description, such as up, down, front, rear, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplification of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.

In the description of the present invention, a plurality of means are one or more, and a plurality of means are two or more. The description to first and second is only for the purpose of distinguishing technical features and is not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of technical features indicated.

In the description of the present invention, unless there is an explicit limitation, the words such as setting, installation, connection, etc. should be understood in a broad sense, and those skilled in the art can reasonably determine the specific meanings of the above words in combination with the specific contents of the technical solution.

Referring to fig. 1 to 3, a fluorescence-immunomagnetic adsorption device includes a collection tube 100 and a magnetic assembly 200. A transition section 110 is arranged between the side wall of the collecting pipe 100 and the bottom wall of the collecting pipe 100, and the inner wall of the transition section 110 is arc-shaped; the magnetic assembly 200 comprises at least two magnetic blocks 220, all the magnetic blocks 220 are arranged side by side, the polarity directions of all the magnetic blocks 220 are the same, the surfaces of all the magnetic blocks 220 facing the collecting pipe 100 are in the same plane, the plane is parallel to the tangent line of any point of the inner wall of the transition section 110, and all the magnetic blocks 220 can abut against the outer wall of the transition section 110.

When the magnetic adsorption device works, the magnetic blocks 220 are close to and abutted against the transition section 110, and the magnetic forces of at least two magnetic blocks 220 are crossed and superposed, so that the mixture of magnetic beads and nucleic acid is subjected to larger magnetic force, the magnetic adsorption effect is good, the magnetic adsorption time can be effectively shortened, and the working efficiency is improved; and the tangent lines of any point of the inner wall of the transition section 110 and the plane of the surfaces of all the magnetic blocks 220 facing the collecting pipe 100 are parallel to each other, and the mixture of the magnetic beads and the nucleic acids is concentrated on the transition section 110, so that the loss of the nucleic acids is reduced in the steps of removing waste liquid and washing, and the accuracy of the subsequent nucleic acid concentration detection is improved.

In some embodiments of the present invention, the cross-section of the collecting tube 100 is annular, so that when the magnetic assembly 200 abuts against the collecting tube 100, the magnetic beads and the nucleic acids are in a concentrated region of the collecting tube 100.

In some embodiments of the present invention, the magnetic adsorption device further includes a bottom plate (not shown in the figure) and a first driving device 400, the collecting pipe 100 is installed on the bottom plate through a horizontal sliding mechanism 500, the first driving device 400 is connected with the collecting pipe 100, the first driving device 400 drives the collecting pipe 100 to move toward the magnetic assembly 200, so that the collecting pipe 100 is close to or away from the magnetic assembly 200, thereby performing or stopping the magnetic assembly 200 from adsorbing magnetic beads and nucleic acids.

In some embodiments of the present invention, the tray 600 is disposed on the horizontal sliding mechanism 500, the reagent plate 700 is slidably mounted on the tray 600, the collecting pipe 100 is disposed on the reagent plate 700, and the first driving device 400 is connected to the tray 600. The first driving device 400 drives the tray 600 to drive the collecting pipe 100 to move; the reagent plate 700 is provided to facilitate the placement and the taking of the collection tube 100, and a groove for accommodating various liquids may be provided on the reagent plate 700.

The utility model discloses a some embodiments, horizontal sliding mechanism 500 includes first slide rail and the first slider of matched with, and first slide rail can be connected with the bottom plate, and first slider can be connected with tray 600, and horizontal sliding mechanism 500 plays the effect of direction, can guide collecting pipe 100 to move towards magnetic component 200 direction.

In some embodiments of the present invention, the first driving device 400 includes a first motor 410 disposed on the bottom plate, a first lead screw 420 connected to an output end of the first motor 410, and a first lead screw nut 430 disposed on the first lead screw 420, and the first lead screw nut 430 is connected to the tray 600. The tray 600 can be driven to slide on the first slide rail by starting the first motor 410. In other embodiments, the first driving device 400 may be a cylinder, and the tray 600 is disposed on an output end of the cylinder.

In this embodiment, two horizontal sliding mechanisms 500 are provided, and the tray 600 is spanned on two first sliders, so that the movement of the tray 600 is more stable, and it should be noted that the number of the horizontal sliding mechanisms 500 may also be one or more than three.

It can be understood that the tray 600 is provided with a sliding groove, the reagent plate 700 is provided with a sliding plate, and the sliding groove and the sliding plate can be mutually matched and connected, so that the reagent plate 700 can be detachably placed on the tray 600, and the reagent plate 700 can be conveniently replaced. In this embodiment, the number of the chutes is five, so the number of the reagent plates 700 is also five, and it should be noted that the number of the chutes is not less than one, and the number of the chutes may be set as needed.

The utility model discloses an in some embodiments, the bottom plate is equipped with lift drive 800 on the region that is close to horizontal glide 500 one end, and magnetic component 200 still includes mounting panel 210, and all magnetic paths 220 are all located on the same surface of mounting panel 210, and mounting panel 210 and lift drive 800's output are connected. It should be understood that the lift drive 800 may drive the mounting plate 210 toward the collection tube 100.

The utility model discloses an in some embodiments, mounting panel 210 is located on the bottom plate through vertical glide machanism 300, it is concrete, vertical glide machanism 300 includes second slide rail and second slider, second slider and mounting panel 210 are connected, the second slide rail is located on the bottom plate, the axis mutually perpendicular of second slide rail and first slide rail, because tray 600 is in the top of first slide rail, so when mounting panel 210 is in second slide rail lower extreme and tray 600 is in the one end that the second slide rail was kept away from to first slide rail, the distance of collecting pipe 100 and magnetic component 200 is the biggest, can not take place the magnetic adsorption effect, when mounting panel 210 is in second slide rail upper end and tray 600 is in the one end that first slide rail is close to the second slide rail, collecting pipe 100 and magnetic component 200 butt, this state is magnetic adsorption operating condition.

In some embodiments of the present invention, the lifting driving device 800 comprises a second motor 810 disposed on the bottom plate, a second lead screw 820 connected to the output end of the second motor 810, and a second lead screw nut 830 disposed on the second lead screw 820, wherein the second lead screw nut 830 is connected to the mounting plate 210. The second motor 810 drives the mounting plate 210 to move in the placement direction of the second slide rail.

The embodiments of the present invention have been described in detail with reference to the accompanying drawings, but the present invention is not limited to the above embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge range of those skilled in the art.

Claims

1. A fluorescent-immune-magnetic adsorption device, comprising:

the collecting pipe (100), there is a transition section (110) between bottom wall and the sidewall, the inner wall of the said transition section (110) is in the form of arc;

magnetic component (200), have two piece at least magnetic blocks (220), all magnetic blocks (220) set up side by side, all the polarity direction of magnetic block (220) is the same, all magnetic block (220) face the surface of collecting pipe (100) is in the coplanar, the plane with the tangent line of changeover portion (110) inner wall arbitrary point is parallel to each other, and all magnetic blocks can butt the outer wall of changeover portion (110).

2. The immunofluorescent magnetic adsorption device according to claim 1, wherein: the collecting pipe device is characterized by further comprising a bottom plate and a first driving device (400), wherein the collecting pipe (100) is installed on the bottom plate through a horizontal sliding mechanism (500), and the first driving device (400) is connected with the collecting pipe (100).

3. The immunofluorescent magnetic adsorption apparatus according to claim 2, wherein: be equipped with tray (600) on horizontal glide machanism (500), slidable mounting has reagent board (700) on tray (600), collecting pipe (100) place in on reagent board (700), first drive arrangement (400) with tray (600) are connected.

4. The immunofluorescent magnetic adsorption device according to claim 3, wherein: the first driving device (400) comprises a first motor (410) arranged on the bottom plate, a first lead screw (420) connected with the output end of the first motor (410), and a first lead screw nut (430) arranged on the first lead screw (420), wherein the first lead screw nut (430) is connected with the tray (600).

5. The immunofluorescent magnetic adsorption apparatus according to claim 3 or 4, wherein: the reagent plate is characterized in that a sliding groove is formed in the tray (600), a sliding block is arranged on the reagent plate (700), and the sliding groove and the sliding block can be connected in a matched mode.

6. The immunofluorescent magnetic adsorption apparatus according to claim 2, wherein: the bottom plate is in be equipped with lift drive (800) on the region of horizontal glide machanism (500) one end, magnetic component (200) still include mounting panel (210), all magnetic path (220) are all located on the same surface of mounting panel (210), mounting panel (210) with the output of lift drive (800) is connected.

7. The immunofluorescent magnetic adsorption device according to claim 6, wherein: the mounting plate (210) is arranged on the bottom plate through a vertical sliding mechanism (300), the lifting driving device (800) comprises a second motor (810) arranged on the bottom plate, a second lead screw (820) connected with the output end of the second motor (810) and a second lead screw nut (830) arranged on the second lead screw (820), and the second lead screw nut (830) is connected with the mounting plate (210).

8. The immunofluorescent magnetic adsorption device according to claim 1, wherein: the cross section of the collecting pipe (100) is annular.