CN2116904U - Infrared detecting instrument for cell gathering - Google Patents
Infrared detecting instrument for cell gathering Download PDFInfo
- Publication number
- CN2116904U CN2116904U CN 91233001 CN91233001U CN2116904U CN 2116904 U CN2116904 U CN 2116904U CN 91233001 CN91233001 CN 91233001 CN 91233001 U CN91233001 U CN 91233001U CN 2116904 U CN2116904 U CN 2116904U
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- garden
- tube
- infrared
- shearing
- blood sample
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Abstract
The utility model discloses an infrared detecting instrument for cell gathering, comprising a stepping electric machine, an infrared luminous tube, a reflecting mirror, a single chip machine, etc. Concentric double cylinders are adopted as shearing devices, with measuring precision raised. According to different shearing speeds, the double cylinders are driven to carry out shearing, after the shearing is stopped, cells in a blood sample are aggregated along with the passage of time, and the intensity of penetrating light is changed. Light generated by the infrared luminous tube is illuminated on the blood sample between the double cylinders by the reflecting mirror, and the light is received by an infrared sensor. The process of gathering which is sheared for a plurality of times by photoelectric conversion is sent into the single chip machine for carrying out storage and calculation, with results output. The utility model is a necessary detecting instrument in medical units.
Description
The utility model is the rheol detecting instrument of biological blood.
Cell aggregation (ME) is erythrocytic a kind of physiological property, it refers to blood under static state or than under the low shear rate, red blood cell is under macromolecular substances effects such as fibrinogen, inter-adhesive, form bunch shape or rouleau formation body, it is the important substance basis of keeping blood viscosity and hemostatic function.(60～80S under higher shear rate
-1More than), these aggregation generation depolymerization, free is single red blood cell, so that red blood cell generation deformation, blood viscosity descends, and blood flow is accelerated in order to passing through the blood vessel also littler than red blood cell diameter, to keep the hemoperfusion of normal microcirculation and assurance tissue and organ.But in some cases, the cell aggregation ability strengthens, even under higher shear rate, still can not depolymerization, even at 300～500S
-1Still have aggregation to exist under the high shear rate.Will influence blood circulation and perfused tissue like this, under pathologic conditions such as atherosclerotic and blood vessel infraction, its influence is more obvious.Therefore the cell aggregation enhancing is a coronary heart disease, important pathologic basis and reason that diseases such as miocardial infarction, apoplexy, diabetes take place.The detection of cell aggregation adopts the ratio of whole blood viscosity under erythrocyte sedimentation rate and the high low shear rate to do approximate estimation the earliest.Therefore error is bigger, and certain limitation is arranged in clinical practice, and developed cone-plate formula erythrocyte aggregation instrument the external end of the seventies, but because cone-plate rotates the instability of formed shearing stress in the shearing field, influence measuring accuracy.It is shear that the utility model has adopted with one heart two gardens tube, makes the shearing stress uniformity in the shearing field, thereby has improved measuring accuracy, is the research of clinical blood aggregation, and the instrumentation that objectifies is provided.
The purpose of this utility model provides a kind of instrumentation of measuring cell aggregation with the method for infrared light.
Accompanying drawing 1 is the fundamental diagram of theory diagram and shear.Accompanying drawing 2 is the instrument outside drawing, and as the specification digest accompanying drawing.
The structural principle of infrared detecting instrument for cell gathering is as follows: this analyzer has stepper motor (1), shear (2), infrared remote receiver (3), A/D change-over panel (4), single-chip microcomputer (5), and printer (6) forms, it is characterized in that shear (2) by place cover plate (7) garden in the heart infraluminescence pipe (8) and place the reflective mirror (10) at interior garden tube (9) bottom and level inclination angle at 45 ° and be fixed on formations such as outer garden tube (12) on the rotating seat (11). Blood sample to be measured (13) is placed between the tube of inside and outside garden. Stepper motor (1) is done rotation by driving and driven gear (14) driven rotary seat (11) and the outer garden tube (12) that is attached thereto. The light that infraluminescence pipe (8) sends sees through blood sample (13) by reflective mirror (10) and passes To infrared remote receiver (3). Interior garden tube (9) is fixed on the framework (16) by supporting arm (15), having diameter at interior garden tube light shield (17) is 1 millimeter small garden hole, and becoming an axis with the center of reflective mirror (10) and the garden heart of interior garden tube, the distance between the tube of inside and outside garden is 0.5～1 millimeter. Inside and outside garden tube is made by transparent material, such as quartz glass, and glass etc. In order to make outer garden tube (12) steady when doing High Rotation Speed, be fixed on the pedestal (18), between pedestal (18) and the base (19) bearing is housed, driven pulley and base (19) also are embedded with bearing (20) simultaneously. Supporting arm (15) is pulled (21) with connection and is fixed with stepper motor (1), to strengthen its globality. Cover plate (7) is fixed with alignment pin with framework (16).
The principle of work of this analyzer is as follows: it is according to the dynamic optical method---the mensuration principle of penetrability is measured the cell aggregation degree.The utility model has adopted two gardens cartridge type viscosity meter to do shearing, because its measuring chamber (between the tube of inside and outside garden) is transparent, can utilize opto-electronic conversion that the penetrability change records of blood sample is got off.
With blood sample (dilution mixes formation blood suspending liquid with blood) the outer garden tube (12) of packing into, interior garden tube (9) is put into during measurement, covered cover plate (7).Stepper motor is by the appointment rotating speed rotational shear of finishing in advance.Aperture on the light transmission light shield (17) that infraluminescence pipe (8) sends after stopping is on the blood suspending liquid inside and outside catoptron (10) is radiated between the tube of garden.Infrared remote receiver (3) can be corresponding electric signal with this signal transition just, through sending into single-chip microcomputer (5) after A/D change-over panel (4) conversion.Because stop to shear As time goes on and constantly gathering of cell in the blood suspending liquid of back, it is transparent that suspending liquid becomes gradually, and therefore seeing through light intensity will strengthen gradually, so just can write down this accumulation process.
At first by the instruction of finishing in advance, single-chip microcomputer sends the step motor drive pulse signal when starting working, and makes stepper motor by the speed rotation of high shearforce, (600S
-1) shear 20S and stop, and carried out Photoelectric Detection 2 seconds, reduce shearforce, i.e. 200S then successively
-1, 100S
-1, 50S
-1, 20S
-1, 10S
-1Each variation (totally 6 times) that all is the cell aggregation degree of 2 seconds such blood suspending liquid reaches shearforce in time at interval all can be sent into single-chip microcomputer and store, and detects the back unified calculation processing that finishes, and by printer (6) result is exported.
Computing formula:
VAT＝ (δ
A)/(δ
b) ＝1- (r
1)/(r)
The VAT-aggregate index, δ
AThe surface area of-unit volume, δ
b-total surface area,
r
1Light transmission capacity during-state of aggregation, the light transmission capacity during r-depolymerization state
Because so the shear that the utility model adopts is compared with the cone-plate formula and is had the higher stable degree and can more accurately measure the cell aggregation parameter, the employing infrared light is a detection means, then cheap, and it is simple in structure easy to operate, and for all be absolutely necessary detection, analytical instrument such as medical administration and organisation, medical colleges and schools and medical research unit, for the clinical prevention ischemic angiocardiopathy and cerebrovascular disease provides reliable basis, and guide medicine for treatment, have bigger social benefit and economic benefit simultaneously.
Claims (3)
1, infrared cell aggregation detector, has stepper motor (1), shear (2), infrared remote receiver (3), A/D change-over panel (4), single-chip microcomputer (5) and printer (6) are formed, it is characterized in that shear (2) by place cover plate (7) garden in the heart infraluminescence pipe (8) and place in garden tube (9) bottom and level inclination angle at 45 reflective mirror (10) and be fixed on outer garden tube formations such as (12) on the rotary seat (11), blood sample to be measured (13) is placed between the tube of inside and outside garden, stepper motor (1) is by main, follower gear (14) driven rotary seat (11) and outer garden tube (12) rotation that is attached thereto, the light that infraluminescence pipe (8) sends sees through blood sample (13) by reflective mirror (10) and reaches infrared remote receiver (3).
2, according to the described infrared cell aggregation detector of claim 1, it is characterized in that described interior garden tube (9) is fixed on the framework (16) by supporting arm (15), on interior garden tube light shield (17), have diameter and be 1 millimeter small garden hole, and becoming an axis with the center of reflective mirror (10) and the garden heart of interior garden tube, the distance between the tube of inside and outside garden is 0.5～1 millimeter.
3,, it is characterized in that described inside and outside garden tube made by transparent material, as quartz glass etc. according to claim 1 or 2 described infrared cell aggregation detectors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91233001 CN2116904U (en) | 1991-12-30 | 1991-12-30 | Infrared detecting instrument for cell gathering |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 91233001 CN2116904U (en) | 1991-12-30 | 1991-12-30 | Infrared detecting instrument for cell gathering |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2116904U true CN2116904U (en) | 1992-09-23 |
Family
ID=4937931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 91233001 Granted CN2116904U (en) | 1991-12-30 | 1991-12-30 | Infrared detecting instrument for cell gathering |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2116904U (en) |
-
1991
- 1991-12-30 CN CN 91233001 patent/CN2116904U/en active Granted
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| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |