CN211584555U

CN211584555U - Novel blood/plasma perfusion device

Info

Publication number: CN211584555U
Application number: CN201922364828.6U
Authority: CN
Inventors: 刘娟娟; 李涛; 李可; 舒桂明
Original assignee: Zibo High Tech Co ltd Tianjin City; Tianjin Third Central Hospital
Current assignee: Zibo High Tech Co ltd Tianjin City; Tianjin Third Central Hospital
Priority date: 2019-12-25
Filing date: 2019-12-25
Publication date: 2020-09-29
Anticipated expiration: 2029-12-25

Abstract

The utility model discloses a novel blood/plasma perfusion device, which comprises a shell, an upper end cover, an upper spiral cover, a lower spiral cover, an upper filtering device and a lower filtering device; the shell is provided with a liquid outlet end and a liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet; a hollow cylindrical lower filtering device is arranged in the shell and is positioned at the liquid inlet end; an upper end cover is arranged at the liquid outlet end of the shell; the upper end cover is provided with a liquid outlet; an upper filtering device is arranged in the shell and is positioned at the liquid outlet end; the shell is filled with blood/plasma perfusion adsorbent. This perfusion ware overall structure is simple, and preparation and equipment are simple and easy, and the casing internal diameter is reduced gradually to the inlet end by the outlet end, and casing inlet end inboard is equipped with cylindric lower filter screen, can effectively avoid the cavity body to form in the use, effectively improves the validity that the adsorbent was clear away to the toxin.

Description

Novel blood/plasma perfusion device

Technical Field

The utility model relates to the field of medical equipment, specifically a novel blood/plasma perfusion ware.

Background

The blood/plasma perfusion is a blood purification technology which achieves the purpose of improving the environment in a body by specifically or non-specifically removing various endogenous or exogenous toxicants in the blood of a patient by means of extracorporeal circulation and utilizing an adsorption resin with a special adsorption function in a blood/plasma perfusion device.

At present, the blood/plasma perfusion technology can remove various blood endotoxins and pathogenic substances, such as uric acid, creatinine, bilirubin, endotoxin, inflammatory cytokines, immunoglobulin and the like, according to different adsorption resins, and the treated diseases also develop from general drug poisoning, liver and kidney diseases to various difficult and complicated diseases such as immune system diseases and the like. With the rapid development of polymer materials and immunology, the development of blood perfusion materials is changing day by day, the blood/plasma perfusion technology is rapidly developed, and the clinical application is more and more extensive.

The traditional blood/plasma perfusion device consists of a cylindrical column body, an upper end cover, a lower end cover and an adsorbent in a containing cavity. However, when blood/plasma perfusion treatment is performed, after blood enters the adsorbent inside the cylindrical column body, the blood flow rate is fast when the blood enters, the blood is easily in contact with the resin in the middle of the main body sufficiently to form effective adsorption, the peripheral adsorbent is not easy to contact with the blood to form a cavity, after the adsorbent in the middle of the column body reaches adsorption balance, toxic substances in the blood cannot be effectively removed when the toxic substances flow, and the adsorbent on the periphery of the column body cannot exert adsorption effectiveness, so that the toxin adsorption efficiency in the treatment process is low, and the treatment effect is further improved.

The document of application No. 201420653776.9 discloses a blood perfusion device, it optimizes traditional blood/plasma perfusion device, hold the intracavity with the tradition and add and establish the baffling board, be used for increasing the liquid flow, the baffling board is gone into liquid end and inlet intercommunication, the baffling board goes out the liquid end and is connected with the liquid outlet, it increases the absorption sufficiency to change the intracavity blood flow direction of holding, improve adsorption efficiency, but do not consider blood to change the flow direction in-process at the flow, the blood cell need bear with the impact of baffling board and because blood constantly gets into but can not in time flow out and the extrusion force that produces, lead to the haemolysis of erythrocyte to increase, increase the treatment risk.

SUMMERY OF THE UTILITY MODEL

To the deficiency of the prior art, the technical problem to be solved by the utility model is to provide a novel blood/plasma perfusion device.

The technical scheme of the utility model for solving the technical problems is to provide a novel blood/plasma perfusion device, which is characterized in that the perfusion device comprises a shell, an upper end cover, an upper spiral cover, a lower spiral cover, an upper filtering device and a lower filtering device; the shell is provided with a liquid outlet end and a liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet; a hollow cylindrical lower filtering device is arranged in the shell and is positioned at the liquid inlet end; an upper end cover is arranged at the liquid outlet end of the shell; the upper end cover is provided with a liquid outlet; an upper filtering device is arranged in the shell and is positioned at the liquid outlet end; the shell is filled with blood/plasma perfusion adsorbent.

Compared with the prior art, the utility model discloses beneficial effect lies in:

(1) this perfusion ware casing outside is smooth cambered surface structure, and the casing internal diameter is reduced gradually to the inlet port end by the outlet port end, forms similar coniform cavity structure, and such structural design can effectively avoid the cavity body to form at the perfusion implementation in-process through the effect to the liquid flow direction, improves the contact rate of liquid and adsorbent, improves adsorption efficiency.

(2) The upper end cover is of a transparent arc-shaped structure, the liquid outlet is positioned in the center, so that air in the shell can be conveniently discharged in the pre-flushing process, and the design of the transparent upper end cover is convenient for observing whether the gas in the tank body is completely discharged.

(3) The casing inlet end inboard is equipped with cylindric lower filter equipment, and liquid gets into the casing from this end after, gets into the filter screen process and does not have any obstruction, can be full of the filter screen rapidly, simultaneously because the filter screen is the columnar structure, liquid can realize effectively shunting all around under velocity of flow pressure, avoids "cavity body" to form, is showing improvement toxin adsorption efficiency.

(4) Adopt disposable injection moulding transparent housing, can avoid because connect the product that the jail leads to and reveal the problem, and be convenient for observe the smooth and easy nature that the perfusion was implemented at the perfusion in-process, can take remedial action in the very first time if take place unusually in the perfusion ware.

Drawings

Fig. 1 is a schematic overall structure diagram of an embodiment of the present invention;

in the figure: 1. a housing; 2. an upper end cover; 3. screwing a cover; 4. screwing down the cover; 5. an upper filtering device; 6. a lower filtration device; 7. a liquid outlet; 8. a liquid inlet; 9. blood/plasma perfusion adsorbents.

Detailed Description

The present invention will be further explained with reference to the following embodiments and accompanying drawings. The specific embodiments are only used for further elaboration of the invention, and do not limit the scope of protection of the claims of the present application.

The utility model provides a novel blood/plasma perfusion device (perfusion device for short), which is characterized in that the perfusion device comprises a shell 1, an upper end cover 2, an upper rotary cover 3, a lower rotary cover 4, an upper filtering device 5 and a lower filtering device 6; the shell 1 is of a smooth transparent arc-shaped cavity truncated cone-shaped structure with a large-opening liquid outlet end and a small-opening liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet 8 for the entry of blood/plasma; the liquid inlet 8 is a medical luer connector and is screwed with a lower screw cap 4; a hollow cylindrical lower filtering device 6 is arranged in the shell 1 and is positioned at the liquid inlet end; the bottom surface of the cylindrical lower filtering device 6, which is closer to the liquid inlet 8, is not provided with a filter screen, and the other bottom surface and the side surface are both provided with filter screens; the liquid outlet end of the shell 1 is provided with an arc-shaped transparent upper end cover 2 which is transparent and is convenient for observing whether the gas in the shell 1 is exhausted; a liquid outlet 7 is formed in the center of the upper end cover 2, so that air in the shell can be conveniently discharged before perfusion is performed, and the formation of an air plug in the treatment process due to insufficient discharge of air in the shell is avoided; the liquid outlet 7 is a medical luer connector and is screwed with an upper screw cap 3; the upper filtering device 5 is arranged in the shell 1 and is positioned at the liquid outlet end, so that the blood/plasma perfusion adsorbent 9 and micro particles falling off from the adsorbent are prevented from flowing out, and the treatment safety is ensured; the inside of the shell 1 is a containing cavity which is filled with blood/plasma perfusion adsorbent 9.

Preferably, the filter screen of the upper filter device 5 and the filter screen of the lower filter device 6 are set to be 50-200 meshes according to the type of the blood/plasma perfusion adsorbent 9, and the meshes of the two are the same.

Preferably, the shell sequentially consists of a slow closing part occupying the length 2/3-5/6 of the shell and a large-amplitude arc closing part occupying the length 1/6-1/3 of the shell from the liquid outlet end to the liquid inlet end.

Preferably, the lower filtering device 6 comprises a cylindrical supporting framework and a filtering net; the supporting framework is a cylindrical structure formed by supporting spokes from circular side surfaces at two ends, a filter screen is fixed on one side surface and one bottom surface of the cylindrical supporting framework, and the other bottom surface which is closer to the liquid inlet 8 is not provided with the filter screen and is communicated with the liquid inlet 8. The upper filtering device 5 is a circular sheet-shaped filter screen.

Preferably, the upper end cap 2, the lower filter device 6 and the upper filter device 5 are all fixed to the housing 1 by ultrasonic welding.

Preferably, the upper screw cap 3 and the lower screw cap 4 are both provided with sealing gaskets which are respectively screwed with the liquid outlet 7 and the liquid inlet 8 to realize the sealing of the perfusion device.

Preferably, the circumferential sides of the upper screw cap 3 and the lower screw cap 4 are both provided with anti-skid convex ribs.

Preferably, the blood/plasma perfusion adsorbent 9 includes various types of adsorbents involved in blood/plasma perfusion treatment such as uric acid, creatinine, bilirubin, endotoxin, various inflammatory cytokines, and immunoglobulin.

The utility model discloses a theory of operation and work flow are:

connecting a liquid outlet 7 and a liquid inlet 8 at two ends of the perfusion device with a blood purification pipeline to establish an extracorporeal circulation passage; this perfusion device is vertical fixed, and inlet 8 is located the below, and liquid outlet 7 is located the top, implements external preflush circulation pipeline process, and liquid is from supreme down gradually through the perfusion device, and the casing 1 is constantly beaten to this in-process, discharges its inside air from liquid outlet 7.

After the pre-flushing is finished, a passage is established with a human body through the double-cavity cannula, the perfusion process is implemented, after blood enters the liquid inlet 8, the lower filtering device 6 is quickly filled with the blood, the blood is shunted to the periphery by the lower filtering device 6, then the blood slowly rises from bottom to top, the formation of a 'cavity body' is reduced, the blood is fully contacted with the blood/plasma perfusion adsorbent 9, and the toxin adsorption efficiency is obviously improved.

The utility model discloses the nothing is mentioned the part and is applicable to prior art.

Claims

1. A novel blood/plasma perfusion device is characterized in that the perfusion device comprises a shell, an upper end cover, an upper spiral cover, a lower spiral cover, an upper filtering device and a lower filtering device; the shell is provided with a liquid outlet end and a liquid inlet end, the inner diameter of the shell is gradually reduced from the liquid outlet end to the liquid inlet end, and the liquid inlet end is provided with a liquid inlet; a hollow cylindrical lower filtering device is arranged in the shell and is positioned at the liquid inlet end; an upper end cover is arranged at the liquid outlet end of the shell; the upper end cover is provided with a liquid outlet; an upper filtering device is arranged in the shell and is positioned at the liquid outlet end; the shell is filled with blood/plasma perfusion adsorbent.

2. The novel blood/plasma perfusion device as claimed in claim 1, wherein the housing is a truncated cone-shaped structure with a cambered transparent cavity having a large-opening liquid outlet end and a small-opening liquid inlet end.

3. The novel blood/plasma perfusion device as claimed in claim 1, wherein the shell comprises a slow closing portion occupying the length of the shell from 2/3 to 5/6 and a large-amplitude arc closing portion occupying the length of the shell from 1/6 to 1/3 in sequence from the liquid outlet end to the liquid inlet end.

4. The novel blood/plasma perfusion device as claimed in claim 1, wherein the upper end cap is arc-shaped and transparent, and the liquid outlet is disposed at the center of the upper end cap.

5. The new blood/plasma perfusion apparatus of claim 1, wherein the upper filter device is a circular sheet filter.

6. The novel blood/plasma perfusion device as claimed in claim 1, wherein the liquid inlet is a luer connector and is screwed with a lower screw cap; the liquid outlet is a luer joint and is screwed with an upper screw cap.

7. The novel hemoperfusion cartridge of claim 1 or 6 wherein the upper and lower screw caps are provided with sealing gaskets therein.

8. The novel hemoperfusion cartridge as claimed in claim 1 or 6, wherein the circumferential sides of the upper screw cap and the lower screw cap are provided with anti-skid ribs.

9. The new blood/plasma perfusion apparatus of claim 1, wherein the lower filtering device comprises a cylindrical support frame and a filter screen; the side face and one bottom surface of the cylindrical supporting framework are fixed with a filter screen, and the other bottom surface which is closer to the liquid inlet is not provided with the filter screen and is communicated with the liquid inlet.

10. The novel blood/plasma perfusion device as claimed in claim 1, wherein the filter screen of the upper filtering device and the filter screen of the lower filtering device are set to be 50-200 meshes.