CN211553956U - Drug absorption system - Google Patents
Drug absorption system Download PDFInfo
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- CN211553956U CN211553956U CN201920538208.7U CN201920538208U CN211553956U CN 211553956 U CN211553956 U CN 211553956U CN 201920538208 U CN201920538208 U CN 201920538208U CN 211553956 U CN211553956 U CN 211553956U
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Abstract
A drug absorption system comprises an absorption pool, a drug delivery system and a sampling system; the drug delivery system is used for conveying the mother liquor with the drugs to the interior of the absorption pool; a permeable film is arranged in the middle of the absorption tank, one side of the permeable film is a mother liquor cavity, and the other side of the permeable film is an absorption cavity; a mother liquor outlet is arranged at the top of the mother liquor cavity, a mother liquor inlet is arranged at the bottom of the mother liquor cavity, the mother liquor outlet is connected with a conduit to discharge mother liquor to the mother liquor supply device, and the mother liquor inlet is connected with a conduit; the sampling system comprises a detection device, a sampling pump, a solvent cup, a final sample cup and a four-way valve; the four-way joint of the four-way valve is respectively connected with the sampling pump, the solvent cup, the final sample cup and the detection device. Through simulation intestinal peristalsis and intestinal environment, can accurately survey the medicine absorption situation in continuous a plurality of hours, not only can survey total absorption data, more can carry out the analysis to the absorbed dose in every unit interval, it is effectual to test.
Description
Technical Field
The utility model belongs to the technical field of medical experimental facilities uses, especially a drug absorption system.
Background
The oral preparation is a common preparation form, the precondition of the oral medicine for exerting the drug effect is that the medicine is released and absorbed by the gastrointestinal tract to enter the body for exerting the pharmacological action (except the medicine which directly exerts the action on the gastrointestinal tract), and the evaluation of the release and the absorption of the medicine is very important content of the oral preparation. In order to simulate the release and absorption of drugs in the gastrointestinal tract (e.g. the intestinal tract), some biomimetic systems have been developed in the prior art. For example, chinese utility model patent No. 201110280230.4 provides a drug absorption apparatus.
This kind of absorption appearance has following shortcoming: the drug is released and absorbed in the gastrointestinal tract in a continuous and dynamic process, the instrument can only detect the drug absorption data of the intestinal tract in one unit time, can not realize the acquisition of the drug absorption data of the intestinal tract in each unit time in a plurality of continuous unit times, and is not beneficial to the detection and analysis of the high-efficiency drug.
SUMMERY OF THE UTILITY MODEL
In order to solve the existing problems, the utility model discloses a drug absorption system, its concrete technical scheme as follows:
a drug absorption system is characterized by comprising an absorption pool, a drug delivery system and a sampling system;
the drug delivery system is used for conveying mother liquor with drugs into the absorption cell and comprises a mother liquor supply device, a sample injection pump and a conduit, wherein the conduit is connected with the absorption cell and the mother liquor supply device, the sample injection pump is arranged on the conduit and is used for stably controlling the flow rate of the mother liquor;
a permeation film is arranged in the middle of the absorption tank, one side of the permeation film is a mother liquor cavity, and the other side of the permeation film is an absorption cavity; a mother liquor outlet is formed in the top of the mother liquor cavity, a mother liquor inlet is formed in the bottom of the mother liquor cavity, the mother liquor outlet is connected with a conduit to discharge mother liquor into the mother liquor providing device, and the mother liquor inlet is connected with the conduit and realizes that the mother liquor is conveyed into the mother liquor cavity from the mother liquor providing device through a sample injection pump; the top of the absorption cavity is provided with a liquid guide port, and one side of the bottom of the absorption cavity is provided with a solvent inlet and a solvent outlet;
the sampling system comprises a detection device, a sampling pump, a solvent cup, a final sample cup and a four-way valve; the four-way joint of the four-way valve is respectively connected with the sampling pump, the solvent cup, the final sample cup and the detection device, one end of the detection device is connected with the four-way valve joint, and the other end of the detection device is connected with the solvent inlet and outlet of the absorption cavity.
Furthermore, the number of the absorption tanks is multiple, the number of the sampling pumps is multiple, the number of the final sample cups is multiple, the number of the solvent cups is one or more, and the number of the detection devices is one or more; the number of the absorption cell, the sample feeding pump, the sampling pump and the final sample cup is consistent.
Further, the detection device is one of a high performance liquid analyzer or a spectrometer.
Furthermore, the detection device comprises a three-way electromagnetic valve and a plurality of sample collecting cups, one joint of the three-way electromagnetic valve is connected with a four-way valve joint, the other two joints of the three-way electromagnetic valve are respectively connected with a solvent inlet and a solvent outlet of the absorption cavity and the sample collecting cups, and the number of the sample collecting cups is multiple.
Further, the mother liquor supply device is a drug dissolution instrument or a solvent cup storing the drug mother liquor.
Further, still include the heat preservation system, the heat preservation system includes heating piece and absorption cell fixation clamp, the absorption cell passes through the absorption cell fixation clamp to be fixed between the heating piece, and the heating piece heats the heat preservation to the absorption cell.
Furthermore, two silica gel blank holders are arranged between the mother liquor cavity and the absorption cavity of the absorption tank, and the permeable film is pressed between the two silica gel blank holders, so that the permeable film is vertically fixed inside the absorption tank; the mother liquid outlet, the mother liquid inlet and the solvent inlet and outlet are luer joints; the liquid guide port is a screwed joint, and a stirrer is arranged in the absorption cavity;
the absorption tank bottom still is provided with stirring son rotary device, stirring son rotary device includes driving motor, driving pulley, driving belt, belt pivot and magnet rotor, driving motor connects driving pulley, and the driving belt that registrates between driving pulley and the belt runner realizes the transmission through the belt, and the magnet rotor is connected at belt pivot top, and the magnet rotor is located stirring son below position.
Furthermore, the drug absorption system also comprises a main frame, the main frame comprises a bottom plate, a sample injection pump box body and a sampling pump box body, the sample injection pump box body and the sampling pump box body are positioned above the bottom plate, and the sample injection pump box body and the sampling pump box body are used for placing a sample injection pump and a sampling pump; a main supporting plate is fixedly arranged at the top of the sampling pump box body and the top of the sampling pump box body, a main cover plate is arranged on the main supporting plate, the main cover plate is arranged in an inclined manner, and a heating block is fixedly arranged on the main cover plate and is arranged in an inclined manner; a transparent cover is arranged above the heating block;
the constant temperature water tank is fixedly arranged on one side of the main rack, the cup dissolving frame is arranged at the top of the constant temperature water tank and used for placing the solvent cup and the final sample cup, and the bottoms of the solvent cup and the final sample cup are located in the constant temperature water tank during use, so that the heat preservation of liquid in the solvent cup and the final sample cup is guaranteed.
Further, the medicine absorption system still includes the control box, the control box passes through the connection of electric lines with injection pump, sampling pump, thermostatted water tank and heating block, realizes signal transmission, the control box is the PLC controller, controls the switch start of injection pump and sampling pump through programming software to control thermostatted water tank and heating block's temperature.
Furthermore, the main support plate is horizontally arranged, a backboard is vertically arranged on one side of the main support plate, and a transparent cover is rotatably connected to the backboard; the main cover plate is a special-shaped plate body, the bottom of one side of the main cover plate is fixedly connected with a main support plate, the other side of the main cover plate is fixedly connected with a back plate, the top of the main cover plate is obliquely arranged, a plurality of heating blocks are arranged at the top of the main cover plate and are uniformly distributed above the main cover plate, the number of the absorption tanks is consistent with that of the heating blocks, and the absorption tanks are also positioned above the main cover plate;
the bottom of the main cover plate is fixedly connected with an installation frame, the installation frame is arranged in parallel with the absorption tank, and the stirrer rotating device is installed on the installation frame; the mounting frame comprises a top plate, a bottom plate, a first connecting column and a second connecting column, wherein the first connecting column is arranged at the bottom of one side of the top plate of the mounting frame, and the second connecting column is arranged at the bottom of the other side of the top plate of the mounting frame; the bottom of the first connecting column is fixedly connected with a driving motor, the driving belt pulley is fixedly arranged at the top of the driving motor, the bottom of the second connecting column is connected with a bottom plate, the belt rotating shaft penetrates through the top plate and the bottom plate, two bearings are arranged on the belt rotating shaft, the two bearings are respectively arranged on the top plate and the bottom plate, and the belt rotating shaft is rotatably connected on the top plate and the bottom plate through the bearings;
a groove is formed in one side of the top of the main cover plate and located below the mother liquid inlet, and the bottom of the groove is fixedly connected with one side, connected with the second connecting column, of the top plate.
Furthermore, a pipeline bracket is arranged on one side of the cup dissolving frame, and a plurality of through holes are formed in the pipeline bracket and used for separating a plurality of guide pipes in use.
Furthermore, the sampling pump is one of an injection pump, a peristaltic pump or a ceramic pump, and the sampling pump is one of the injection pump, the peristaltic pump and the ceramic pump.
The utility model has the advantages that:
the utility model discloses a simulation intestinal wriggling and intestinal environment can accurately survey medicine absorption situation in a plurality of continuous hours, not only can survey the totality and absorb data, more can carry out the analysis to the absorbed dose in every unit interval, and experimental effect is good.
The utility model discloses a set up a plurality of absorption tanks, sampling pump, can carry out the multiunit mother liquor simultaneously and test, improve experimental efficiency, the availability factor is high.
Set up the stirring seed that magnet constitutes in absorption cavity, the stirring seed is at the inside rotation of absorption cavity, can simulate human inside blood and flow, is favorable to the experiment to go on, and the result of use is good.
Two detection devices are adopted, and the high performance liquid analyzer is applied to online detection, can synchronously detect absorption data in real time, and has high efficiency; the sample collecting cup is applied to off-line detection, can be subsequently transferred to a detection mechanism for next detection, and is low in cost and convenient to use.
Drawings
Fig. 1 is a schematic diagram of the system principle of embodiment 1 of the present invention.
Fig. 2 is a schematic diagram of embodiment 2 of the present invention.
Figure 3 is a schematic view of the absorption system of the present invention.
Figure 4 is a schematic view of the absorption system of the present invention with the transparent cover open.
Fig. 5 is a schematic view of the installation of the absorption cell of the present invention on the heating block.
Fig. 6 is a schematic sectional view of the absorption cell of the present invention mounted on the heating block.
Fig. 7 is a schematic view of the absorption tank of the present invention.
Fig. 8 is an exploded view of the absorption tank of the present invention.
List of reference numerals:
an absorption tank 1, a permeable membrane 11, a mother liquor cavity 12, a mother liquor outlet 13, a mother liquor inlet 14, an absorption cavity 15, a liquid guide port 16, a solvent inlet and outlet 17, a silica gel blank holder 18 and a stirrer 19;
a drug delivery system 2, a mother liquor supply device 21, a sample injection pump 22 and a conduit 23;
a sampling system 3, a detection device 31, an electromagnetic valve 311, a sample collection cup 312, a sampling pump 32, a solvent cup 33, a final sample cup 34, a four-way valve 35,
A heat preservation system 4, a heating block 41, an absorption pool fixing clamp 42,
The stirrer rotating device 5, a driving motor 51, a driving belt pulley 52, a transmission belt 53, a belt rotating shaft 54, a bearing 541 and a magnet rotor 55;
the device comprises a main frame 6, a bottom plate 61, a sample pump box 62, a sample pump box 63, a main support plate 64, a main cover plate 65, a groove 651, a transparent cover 66, a thermostatic water tank 67, a dissolving cup holder 68, a final sample cup placing hole 681, a solvent cup placing hole 682, a pipeline holder 69, a back plate 610 and a transparent cover 611;
Detailed Description
For making the technical scheme of the utility model clear more clearly and definitely, it is right to combine the drawing below the utility model discloses further describe, any is right the utility model discloses technical scheme's technical characteristic carries out the scheme that equivalent replacement and conventional reasoning reachs and all falls into the utility model discloses protection scope. The fixed connection, the fixed setting that mention in this embodiment are one or more in the publicly known connected mode that technical personnel in the field know such as hot melt integral type shaping, screw connection, welding, its connection principle is in the embodiment of the utility model provides a do not describe in detail.
Example 1
Referring to fig. 1, a drug absorption system for on-line detection of drug absorption is shown, which is characterized by comprising an absorption cell, a drug delivery system and a sampling system;
the drug delivery system is used for conveying mother liquor with drugs into the absorption cell and comprises a mother liquor supply device, a sample injection pump and a conduit, wherein the conduit is connected with the absorption cell and the mother liquor supply device, the sample injection pump is arranged on the conduit and is used for stably controlling the flow rate of the mother liquor; 22
A permeable membrane is arranged in the middle of the absorption tank, the permeable membrane is an intestinal membrane, one side of the permeable membrane is a mother liquor cavity, and the other side of the permeable membrane is an absorption cavity; a mother liquor outlet is formed in the top of the mother liquor cavity, a mother liquor inlet is formed in the bottom of the mother liquor cavity, the mother liquor outlet is connected with a conduit to discharge mother liquor into the mother liquor providing device, and the mother liquor inlet is connected with the conduit and realizes that the mother liquor is conveyed into the mother liquor cavity from the mother liquor providing device through a sample injection pump; the top of the absorption cavity is provided with a liquid guide port, and one side of the bottom of the absorption cavity is provided with a solvent inlet and a solvent outlet;
the sampling system comprises a detection device, a sampling pump, a solvent cup, a final sample cup and a four-way valve; the four-way joint of the four-way valve is respectively connected with the sampling pump, the solvent cup, the final sample cup and the detection device, one end of the detection device is connected with the four-way valve joint, and the other end of the detection device is connected with the solvent inlet and outlet of the absorption cavity.
Furthermore, the number of the absorption pools is 8, the number of the sampling pumps is 8, the number of the final sample cups is 8, the number of the solvent cups is one, and the number of the detection devices is one. All sampling pumps sample from a solvent cup;
further, the detection device is a high performance liquid analyzer.
Further, the mother liquor supply device is a drug dissolution instrument.
Further, still include the heat preservation system, the heat preservation system includes heating piece and absorption cell fixation clamp, the absorption cell passes through the absorption cell fixation clamp to be fixed between the heating piece, and the heating piece heats the heat preservation to the absorption cell.
Furthermore, two silica gel blank holders are arranged between the mother liquor cavity and the absorption cavity of the absorption tank, and the permeable film is pressed between the two silica gel blank holders, so that the permeable film is vertically fixed inside the absorption tank; the mother liquid outlet, the mother liquid inlet and the solvent inlet and outlet are luer joints; the liquid guide port is a screwed joint, and a stirrer is arranged in the absorption cavity;
the absorption tank bottom still is provided with stirring son rotary device, 23 stirring son rotary device includes driving motor, driving pulley, driving belt, belt pivot and magnet rotor, driving motor connects driving pulley, and the driving belt that registrates between driving pulley and the belt runner realizes the transmission through the belt, and the magnet rotor is connected at belt pivot top, and the magnet rotor is located stirring son below position.
When absorbing the inside liquid that is full of cavity and absorbing the experiment, the motor drives the drive pulley and rotates, the drive pulley passes through driving belt and drives the belt runner and rotate, the belt runner drives the magnet rotor and rotates, the stirring is the magnet structure, the magnet rotor is by N utmost point and S level with the stirring, under the effect of magnetic force, the magnet rotor keeps unanimous with stirring N level and S level all the time, consequently the magnet rotor is when rotating, drive the stirring through magnetic force effect and rotate, realize the stirring inside rotatory at the absorption cavity, the inside blood flow of simulation human body.
The threaded connector of the liquid guide port is internally provided with an extremely fine through hole, and the absorption tank which is obliquely arranged in a matched mode can be favorable for discharging internal gas when the absorption tank is used, so that the internal gas is guaranteed, and the experimental effect is favorably guaranteed.
Furthermore, the drug absorption system also comprises a main frame, the main frame comprises a bottom plate, a sample injection pump box body and a sampling pump box body, the sample injection pump box body and the sampling pump box body are positioned above the bottom plate, the sample injection pump box body and the sampling pump box body are used for placing eight sample injection pumps and eight sampling pumps, and one sample injection pump and one sampling pump correspond to one absorption cell and one final sample cup; a main supporting plate is fixedly arranged at the top of the sampling pump box body and the top of the sampling pump box body, a main cover plate is arranged on the main supporting plate, the main cover plate is arranged in an inclined manner, and a heating block is fixedly arranged on the main cover plate and is arranged in an inclined manner; a transparent cover is arranged above the heating block;
the fixed constant temperature water tank that is provided with in main frame one side, constant temperature water tank top is provided with dissolves the glass stand, dissolve and be provided with 8 final sample cups on the glass stand and place the hole and 1 menstruum drinking cup and place the hole for place menstruum drinking cup and final sample cup, menstruum drinking cup and final sample cup bottom are located constant temperature water tank during the use, guarantee that menstruum drinking cup and the inside liquid of final sample cup keep warm.
Further, the medicine absorption system still includes the control box, the control box passes through the connection of electric lines with injection pump, sampling pump, thermostatted water tank and heating block, realizes signal transmission, the control box is the PLC controller, controls the switch start of injection pump and sampling pump through programming software to control thermostatted water tank and heating block's temperature.
Furthermore, the control box is fixedly arranged on the main supporting plate and is positioned on one side of the main cover plate.
Furthermore, the main support plate is horizontally arranged, a backboard is vertically arranged on one side of the main support plate, and a transparent cover is rotatably connected to the backboard; the main cover plate is a special-shaped plate body, the bottom of one side of the main cover plate is fixedly connected with a main support plate, the other side of the main cover plate is fixedly connected with a back plate, the top of the main cover plate is obliquely arranged, heating blocks are arranged on the top of the main cover plate, the number of the heating blocks is 8, the heating blocks are uniformly distributed above the main cover plate, the number of the absorption tanks is consistent with that of the heating blocks, and the absorption tanks are also located above the main cover plate;
the bottom of the main cover plate is fixedly connected with an installation frame, the installation frame is arranged in parallel with the absorption tank, and the stirrer rotating device is installed on the installation frame; the mounting frame comprises a top plate, a bottom plate, a first connecting column and a second connecting column, wherein the first connecting column is arranged at the bottom of one side of the top plate of the mounting frame, and the second connecting column is arranged at the bottom of the other side of the top plate of the mounting frame; the bottom of the first connecting column is fixedly connected with a driving motor, the driving belt pulley is fixedly arranged at the top of the driving motor, the bottom of the second connecting column is connected with a bottom plate, the belt rotating shaft penetrates through the top plate and the bottom plate, two bearings are arranged on the belt rotating shaft, the two bearings are respectively arranged on the top plate and the bottom plate, and the belt rotating shaft is rotatably connected on the top plate and the bottom plate through the bearings;
a groove is formed in one side of the top of the main cover plate and located below the mother liquid inlet, and the bottom of the groove is fixedly connected with one side, connected with the second connecting column, of the top plate.
Furthermore, a pipeline bracket is arranged on one side of the cup dissolving frame, and a plurality of through holes are formed in the pipeline bracket and used for separating a plurality of guide pipes in use.
Furthermore, the sampling pump is a peristaltic pump, and the sampling pump is an injection pump.
The high-performance liquid analyzer in the embodiment can replace a component light spectrometer, and the using effect is the same.
A drug absorption sampling method is characterized by comprising the following steps:
(1) opening a sample injection pump, pumping the mother liquor in the mother liquor supply device into a mother liquor cavity of the absorption tank, and discharging the mother liquor into the mother liquor supply device through a mother liquor outlet, so that the mother liquor circulates between the mother liquor supply device and the mother liquor cavity to simulate intestinal peristalsis;
(2) opening a channel between a four-way valve sampling pump and a solvent cup, closing other channels of the four-way valve, extracting 10ml of solvent with the pH value of 7.4 in the solvent cup by the sampling pump, and enabling 10ml of solvent to enter the sampling pump;
(3) opening a channel between a four-way valve sampling pump and a detection device, and closing other channels of the four-way valve, wherein the detection device is a high-efficiency liquid phase analyzer, the sampling pump conveys 10ML of solvent into an absorption cavity of an absorption cell, and the solvent without liquid medicine can directly enter the absorption cavity through the high-efficiency liquid phase analyzer; closing a channel between the four-way valve sampling pump and the detection device, and reacting the solvent for 1 hour after the solvent is in the absorption cavity;
(4) opening a channel between a four-way valve sampling pump and the high-performance liquid analyzer, closing other channels of the four-way valve, pumping 10ml of solvent in the absorption cavity into the high-performance liquid analyzer by the sampling pump, and setting to leave 5ml for detection by the high-performance liquid analyzer; pumping the residual 5ml of solvent into a sampling pump;
(5) opening a channel between a four-way valve sampling pump and the final sample cup, closing other channels of the four-way valve, and transmitting the residual 5ml of solvent into the final sample cup by the sampling pump to finish the first hour of absorption data acquisition;
(6) repeating the steps (1) to (5) eight times to obtain absorption data acquisition within 8 hours, wherein a high performance liquid analyzer is provided with 8 analysis tube groups, each analysis tube group comprises 8 analysis tubes, eight absorption cells work simultaneously, the high performance liquid analyzer respectively stores, detects and analyzes drug absorption data within each hour, one analysis tube group corresponds to one absorption cell, and the drug absorption data of each hour of the absorption cell corresponds to each analysis tube of the group; and 5ml of residual solvent in 8 hours is completely placed into one final sample cup, 40ml of final solution is obtained from one final sample cup, eight absorption pools correspond to eight final sample cups, and the total amount of the absorbed medicines in the absorption pool in 8 hours can be obtained by detecting the solution in one final sample cup.
Example 2
Referring to fig. 2, a drug absorption system for off-line detection of drug absorption is characterized by comprising an absorption cell, a drug delivery system and a sampling system;
the drug delivery system is used for conveying mother liquor with drugs into the absorption cell and comprises a mother liquor supply device, a sample injection pump and a conduit, wherein the conduit is connected with the absorption cell and the mother liquor supply device, the sample injection pump is arranged on the conduit and is used for stably controlling the flow rate of the mother liquor;
a permeable membrane is arranged in the middle of the absorption tank, the permeable membrane is an intestinal membrane, one side of the permeable membrane is a mother liquor cavity, and the other side of the permeable membrane is an absorption cavity; a mother liquor outlet is formed in the top of the mother liquor cavity, a mother liquor inlet is formed in the bottom of the mother liquor cavity, the mother liquor outlet is connected with a conduit to discharge mother liquor into the mother liquor providing device, and the mother liquor inlet is connected with the conduit and realizes that the mother liquor is conveyed into the mother liquor cavity from the mother liquor providing device through a sample injection pump; the top of the absorption cavity is provided with a liquid guide port, and one side of the bottom of the absorption cavity is provided with a solvent inlet and a solvent outlet;
the sampling system comprises a detection device, a sampling pump, a solvent cup, a final sample cup and a four-way valve; the four-way joint of the four-way valve is respectively connected with the sampling pump, the solvent cup, the final sample cup and the detection device, one end of the detection device is connected with the four-way valve joint, and the other end of the detection device is connected with the solvent inlet and outlet of the absorption cavity.
Furthermore, the number of the absorption tanks is 8, the number of the sampling pumps is 8, the number of the final sample cups is 8, and the number of the solvent cups is 2; the number of the absorption cell, the sample feeding pump, the sampling pump and the final sample cup is consistent. Wherein 4 sampling pumps sample from one solvent cup, and the other 4 sampling pumps sample from the other solvent cup;
furthermore, the detection device comprises a three-way electromagnetic valve and sample collection cups, one joint of the three-way electromagnetic valve is connected with a four-way valve joint, the other two joints of the three-way electromagnetic valve are respectively connected with a solvent inlet and a solvent outlet of the absorption cavity and the sample collection cups, the number of the sample collection cups is 8, and the number of each group is 8.
Further, the mother liquor supply device is a solvent cup for storing the medicine mother liquor.
Further, still include the heat preservation system, the heat preservation system includes heating piece and absorption cell fixation clamp, the absorption cell passes through the absorption cell fixation clamp to be fixed between the heating piece, and the heating piece heats the heat preservation to the absorption cell.
Furthermore, two silica gel blank holders are arranged between the mother liquor cavity and the absorption cavity of the absorption tank, and the permeable film is pressed between the two silica gel blank holders, so that the permeable film is vertically fixed inside the absorption tank; the mother liquid outlet, the mother liquid inlet and the solvent inlet and outlet are luer joints; the liquid guide port is a screwed joint, and a stirrer is arranged in the absorption cavity;
the absorption tank bottom still is provided with stirring son rotary device, stirring son rotary device includes driving motor, driving pulley, driving belt, belt pivot and magnet rotor, driving motor connects driving pulley, and the driving belt that registrates between driving pulley and the belt runner realizes the transmission through the belt, and the magnet rotor is connected at belt pivot top, and the magnet rotor is located stirring son below position.
When absorbing the inside liquid that is full of cavity and absorbing the experiment, the motor drives the drive pulley and rotates, the drive pulley passes through driving belt and drives the belt runner and rotate, the belt runner drives the magnet rotor and rotates, the stirring is the magnet structure, the magnet rotor is by N utmost point and S level with the stirring, under the effect of magnetic force, the magnet rotor keeps unanimous with stirring N level and S level all the time, consequently the magnet rotor is when rotating, drive the stirring through magnetic force effect and rotate, realize the stirring inside rotatory at the absorption cavity, the inside blood flow of simulation human body.
The threaded connector of the liquid guide port is internally provided with an extremely fine through hole, and the absorption tank which is obliquely arranged in a matched mode can be favorable for discharging internal gas when the absorption tank is used, so that the internal gas is guaranteed, and the experimental effect is favorably guaranteed.
Furthermore, the drug absorption system also comprises a main frame, the main frame comprises a bottom plate, a sample injection pump box body and a sampling pump box body, the sample injection pump box body and the sampling pump box body are positioned above the bottom plate, the sample injection pump box body and the sampling pump box body are used for placing eight sample injection pumps and eight sampling pumps, and one sample injection pump and one sampling pump correspond to one absorption cell and one final sample cup; a main supporting plate is fixedly arranged at the top of the sampling pump box body and the top of the sampling pump box body, a main cover plate is arranged on the main supporting plate, the main cover plate is arranged in an inclined manner, and a heating block is fixedly arranged on the main cover plate and is arranged in an inclined manner; a transparent cover is arranged above the heating block;
the fixed constant temperature water tank that is provided with in main frame one side, constant temperature water tank top is provided with dissolves the glass stand, dissolve and be provided with 8 final sample cups on the glass stand and place the hole and 1 menstruum drinking cup and place the hole for place menstruum drinking cup and final sample cup, menstruum drinking cup and final sample cup bottom are located constant temperature water tank during the use, guarantee that menstruum drinking cup and the inside liquid of final sample cup keep warm.
Further, the medicine absorption system still includes the control box, the control box passes through the connection of electric lines with injection pump, sampling pump, thermostatted water tank and heating block, realizes signal transmission, the control box is the PLC controller, controls the switch start of injection pump and sampling pump through programming software to control thermostatted water tank and heating block's temperature.
Furthermore, the control box is fixedly arranged on the main supporting plate and is positioned on one side of the main cover plate.
Furthermore, the main support plate is horizontally arranged, a backboard is vertically arranged on one side of the main support plate, and a transparent cover is rotatably connected to the backboard; the main cover plate is a special-shaped plate body, the bottom of one side of the main cover plate is fixedly connected with a main support plate, the other side of the main cover plate is fixedly connected with a back plate, the top of the main cover plate is obliquely arranged, a plurality of heating blocks are arranged at the top of the main cover plate and are uniformly distributed above the main cover plate, the number of the absorption tanks is consistent with that of the heating blocks, and the absorption tanks are also positioned above the main cover plate;
the bottom of the main cover plate is fixedly connected with an installation frame, the installation frame is arranged in parallel with the absorption tank, and the stirrer rotating device is installed on the installation frame; the mounting frame comprises a top plate, a bottom plate, a first connecting column and a second connecting column, wherein the first connecting column is arranged at the bottom of one side of the top plate of the mounting frame, and the second connecting column is arranged at the bottom of the other side of the top plate of the mounting frame; the bottom of the first connecting column is fixedly connected with a driving motor, the driving belt pulley is fixedly arranged at the top of the driving motor, the bottom of the second connecting column is connected with a bottom plate, the belt rotating shaft penetrates through the top plate and the bottom plate, two bearings are arranged on the belt rotating shaft, the two bearings are respectively arranged on the top plate and the bottom plate, and the belt rotating shaft is rotatably connected on the top plate and the bottom plate through the bearings;
a groove is formed in one side of the top of the main cover plate and located below the mother liquid inlet, and the bottom of the groove is fixedly connected with one side, connected with the second connecting column, of the top plate.
Furthermore, a pipeline bracket is arranged on one side of the cup dissolving frame, and a plurality of through holes are formed in the pipeline bracket and used for separating a plurality of guide pipes in use.
Furthermore, the sampling pump is a ceramic injection pump, and the sampling pump is a ceramic injection pump.
A drug absorption sampling method is characterized by comprising the following steps:
(1) opening a sample injection pump, pumping the mother liquor in the mother liquor supply device into a mother liquor cavity of the absorption tank, and discharging the mother liquor into the mother liquor supply device through a mother liquor outlet, so that the mother liquor circulates between the mother liquor supply device and the mother liquor cavity to simulate intestinal peristalsis;
(2) opening a channel between a four-way valve sampling pump and a solvent cup, closing other channels of the four-way valve, extracting 10ml of solvent with the pH value of 7.4 in the solvent cup by the sampling pump, and enabling 10ml of solvent to enter the sampling pump;
(3) opening a channel between a four-way valve sampling pump and a detection device, and closing other channels of the four-way valve; at the moment, the detection device is a three-way electromagnetic valve and a sample collection cup, the three-way electromagnetic valve opens the absorption cavity and a sampling pump channel, the sampling pump conveys 10ML of solvent into the absorption cavity of the absorption cell, the channel between the four-way valve sampling pump and the detection device is closed, and the solvent reacts for 1 hour after inside the absorption cavity;
(4) opening a channel between a four-way valve sampling pump and a detection device, and closing other channels of the four-way valve; the three-way electromagnetic valve opens the channel between the absorption cavity and the sampling pump, and the sampling pump extracts 10ml of solvent in the absorption cavity to enter the sampling pump;
(5) the electromagnetic valve opens the channel between the sample collection cup and the sampling pump, and the sampling pump sends 2ml of solvent into the sample collection cup;
(6) opening a channel between a four-way valve sampling pump and the final sample cup, and closing other channels of the four-way valve; the sampling pump transmits the residual 8ml of solvent into a final sample cup to finish the acquisition of absorption data in the first hour;
(7) repeating the steps (1) to (6) for 8 times to obtain absorption data acquisition within 8 hours, wherein the number of the final sample cups is 8, the number of the sample collection cups is 8, each group of the sample collection cups is 8, the eight absorption cells work simultaneously, one group of the sample collection cups corresponds to one absorption cell, one sample collection cup in the same group is replaced in each hour, and the drug absorption data corresponding to one absorption cell in each hour is obtained by detecting each sample collection cup; and (3) putting all the residual 8ml of solvent in 8 hours into one final sample cup to obtain 64ml of final sample solution, wherein each absorption cell corresponds to eight final sample cups, and the total amount of the absorbed medicines in the absorption cell in 8 hours can be obtained by detecting the solution in one final sample cup.
Claims (10)
1. A drug absorption system is characterized by comprising an absorption pool, a drug delivery system and a sampling system;
the drug delivery system is used for conveying mother liquor with drugs into the absorption cell and comprises a mother liquor supply device, a sample injection pump and a conduit, wherein the conduit is connected with the absorption cell and the mother liquor supply device, the sample injection pump is arranged on the conduit and is used for stably controlling the flow rate of the mother liquor;
a permeation film is arranged in the middle of the absorption tank, one side of the permeation film is a mother liquor cavity, and the other side of the permeation film is an absorption cavity; a mother liquor outlet is formed in the top of the mother liquor cavity, a mother liquor inlet is formed in the bottom of the mother liquor cavity, the mother liquor outlet is connected with a conduit to discharge mother liquor into the mother liquor providing device, and the mother liquor inlet is connected with the conduit and realizes that the mother liquor is conveyed into the mother liquor cavity from the mother liquor providing device through a sample injection pump; the top of the absorption cavity is provided with a liquid guide port, and one side of the bottom of the absorption cavity is provided with a solvent inlet and a solvent outlet;
the sampling system comprises a detection device, a sampling pump, a solvent cup, a final sample cup and a four-way valve; the four-way joint of the four-way valve is respectively connected with the sampling pump, the solvent cup, the final sample cup and the detection device, one end of the detection device is connected with the four-way valve joint, and the other end of the detection device is connected with the solvent inlet and outlet of the absorption cavity.
2. The drug absorption system of claim 1, wherein the absorption cell is in plurality, the sampling pump is in plurality, the final sample cup is in plurality, the solvent cup is in one or more, and the detection device is in one or more; the number of the absorption cell, the sample feeding pump, the sampling pump and the final sample cup is consistent.
3. A drug absorption system as in claim 1 wherein said detection means is a high performance liquid analyzer.
4. The drug absorption system according to claim 1, wherein the detection device comprises a three-way solenoid valve and a plurality of sample collection cups, one connector of the three-way solenoid valve is connected with a four-way valve connector, the other two connectors of the three-way solenoid valve are respectively connected with the solvent inlet/outlet of the absorption cavity and the sample collection cups, and the number of the sample collection cups is multiple.
5. The drug absorption system of claim 1, wherein the stock solution providing means is a drug dissolution apparatus or a solvent cup containing a stock solution of the drug.
6. The drug absorption system of claim 1 further comprising a thermal insulation system, the thermal insulation system comprising heating blocks and absorption cell retaining clips, the absorption cells being retained between the heating blocks by the absorption cell retaining clips, the heating blocks heating and insulating the absorption cells.
7. The drug absorption system of claim 1, wherein two silica gel beads are disposed between the mother liquor chamber and the absorption chamber of the absorption cell, and the permeable membrane is pressed between the two silica gel beads, such that the permeable membrane is vertically fixed inside the absorption cell; the mother liquid outlet, the mother liquid inlet and the solvent inlet and outlet are luer joints; the liquid guide port is a screwed joint, and a stirrer is arranged in the absorption cavity;
the absorption tank bottom still is provided with stirring son rotary device, stirring son rotary device includes driving motor, driving pulley, driving belt, belt pivot and magnet rotor, driving motor connects driving pulley, and the driving belt that registrates between driving pulley and the belt runner realizes the transmission through the belt, and the magnet rotor is connected at belt pivot top, and the magnet rotor is located stirring son below position.
8. The drug absorption system according to claim 1, further comprising a control box, wherein the control box is connected to the sample pump, the sampling pump, the thermostatic water tank and the heating block through wires for signal transmission, the control box is a PLC controller, switches of the sample pump and the sampling pump are controlled to be started through programming software, and temperatures of the thermostatic water tank and the heating block are controlled.
9. The drug absorption system of claim 6, further comprising a main frame, wherein the main frame comprises a bottom plate, a sample pump box and a sampling pump box, the sample pump box and the sampling pump box are located above the bottom plate, and the sample pump box and the sampling pump box are used for placing the sample pump and the sampling pump; a main supporting plate is fixedly arranged at the top of the sampling pump box body and the top of the sampling pump box body, a main cover plate is arranged on the main supporting plate, the main cover plate is arranged in an inclined manner, and a heating block is fixedly arranged on the main cover plate and is arranged in an inclined manner; a transparent cover is arranged above the heating block;
the constant temperature water tank is fixedly arranged on one side of the main rack, the cup dissolving frame is arranged at the top of the constant temperature water tank and used for placing the solvent cup and the final sample cup, and the bottoms of the solvent cup and the final sample cup are located in the constant temperature water tank during use, so that the heat preservation of liquid in the solvent cup and the final sample cup is guaranteed.
10. The drug absorption system of claim 9, wherein the main support plate is horizontally disposed, a back plate is vertically disposed on one side of the main support plate, and a transparent cover is rotatably connected to the back plate; the main cover plate is a special-shaped plate body, the bottom of one side of the main cover plate is fixedly connected with a main support plate, the other side of the main cover plate is fixedly connected with a back plate, the top of the main cover plate is obliquely arranged, a plurality of heating blocks are arranged at the top of the main cover plate and are uniformly distributed above the main cover plate, the number of the absorption tanks is consistent with that of the heating blocks, and the absorption tanks are also positioned above the main cover plate;
the bottom of the absorption tank is also provided with a stirrer rotating device, the stirrer rotating device comprises a driving motor, a driving belt pulley, a transmission belt, a belt rotating shaft and a magnet rotor, the driving motor is connected with the driving belt pulley, the transmission belt is sleeved between the driving belt pulley and the belt rotating wheel, transmission is realized through the belt, the top of the belt rotating shaft is connected with the magnet rotor, and the magnet rotor is positioned below the stirrer;
the bottom of the main cover plate is fixedly connected with an installation frame, the installation frame is arranged in parallel with the absorption tank, and the stirrer rotating device is installed on the installation frame; the mounting frame comprises a top plate, a bottom plate, a first connecting column and a second connecting column, wherein the first connecting column is arranged at the bottom of one side of the top plate of the mounting frame, and the second connecting column is arranged at the bottom of the other side of the top plate of the mounting frame; the belt conveyor is characterized in that the bottom of the first connecting column is fixedly connected with a driving motor, a driving belt pulley is fixedly arranged at the top of the driving motor, the bottom of the second connecting column is connected with a bottom plate, a belt rotating shaft penetrates through the top plate and the bottom plate, two bearings are arranged on the belt rotating shaft and are respectively installed on the top plate and the bottom plate, and the belt rotating shaft is rotatably connected with the top plate and the bottom plate through the bearings.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920538208.7U CN211553956U (en) | 2019-04-19 | 2019-04-19 | Drug absorption system |
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| CN201920538208.7U CN211553956U (en) | 2019-04-19 | 2019-04-19 | Drug absorption system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110045072A (en) * | 2019-04-19 | 2019-07-23 | 禄根仪器(镇江)有限公司 | A kind of drug absorption system and its absorb sampling method |
| CN113009094A (en) * | 2021-02-03 | 2021-06-22 | 禄根仪器(镇江)有限公司 | Novel high-efficient medicine dissolves out appearance |
-
2019
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110045072A (en) * | 2019-04-19 | 2019-07-23 | 禄根仪器(镇江)有限公司 | A kind of drug absorption system and its absorb sampling method |
| CN110045072B (en) * | 2019-04-19 | 2023-12-05 | 禄根仪器(镇江)有限公司 | Drug absorption system and absorption sampling method thereof |
| CN113009094A (en) * | 2021-02-03 | 2021-06-22 | 禄根仪器(镇江)有限公司 | Novel high-efficient medicine dissolves out appearance |
| CN113009094B (en) * | 2021-02-03 | 2023-07-07 | 禄根仪器(镇江)有限公司 | Novel high-efficient medicine dissolves out appearance |
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