CN211294426U - Organ perfusion teaching and training system - Google Patents
Organ perfusion teaching and training system Download PDFInfo
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- CN211294426U CN211294426U CN201921443568.5U CN201921443568U CN211294426U CN 211294426 U CN211294426 U CN 211294426U CN 201921443568 U CN201921443568 U CN 201921443568U CN 211294426 U CN211294426 U CN 211294426U
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/285—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine for injections, endoscopy, bronchoscopy, sigmoidscopy, insertion of contraceptive devices or enemas
Abstract
The utility model provides an organ fills teaching training system, include: organ cartridge (2): for receiving organs (1) of a living being and accessory blood vessels; liquid storage bin (3): the device is positioned below the organ bin (2) and used for storing circulating perfusate; temperature maintaining device (4): for maintaining the temperature of an organ (1) of a living being; priming line (8): the liquid storage bin (3) and the subsidiary vessel of the organism organ (1) are connected, and the organism organ (1) and the subsidiary vessel are pressurized and circularly perfused under the driving of a pump (7); pump (7): pressurizing a circulation pipeline (8) and pressurizing and circularly perfusing the organism organ (1) and the accessory blood vessel; a display (35) for displaying the operation video; a base (61) for supporting, moving, and lifting the integrated device; an organ perfusion preservation apparatus is capable of perfusing a single or a plurality of biological organs (1) simultaneously. The utility model discloses can perfuse a plurality of organs simultaneously.
Description
Technical Field
The utility model relates to a medical teaching training system, more specifically relates to an organ fills teaching training system.
Background
In the medical training process, in order to ensure that the training effects of surgical laparoscopes, natural orifice endoscopes, surgical robots, medical digestive endoscopes and the like are more real, large animals are required to be utilized for operation training. However, with the progress of social civilization and the development of medical ethics, the factors of expensive cost for establishing a large animal operating room, expensive cost for a single large animal experiment and the like limit the operation training by using large animals. At present, medical training mostly uses edible large animal organs purchased in the market for training, but the organs are isolated dead organs without vitality and are single organs, so that the vitality is lacked, the difference between the survival state of the organs and the survival state of the body is large, bleeding cannot be accurately simulated, intestines cannot creep, livers cannot produce bile, kidneys cannot produce urine, and hearts cannot jump, so the simulation effect is poor; moreover, the whole anatomical structure of a single organ is destroyed, and the system anatomical training cannot be carried out, so that the training effect is poor. The virtual reality training devices appearing in recent years also have many defects, such as lack of anatomical variation, lack of authenticity of operation, high selling price and the like.
The device can be used for mechanical perfusion preservation of large animal organs, and can utilize organs and blood of pigs obtained from slaughterhouses to connect the machine for experiment under the increasingly strict situation of animal ethics and protection systems. The method has the advantages that the ethical examination is avoided, the laboratory application and the ethical application period are avoided, the experimental cost is cheaper, the number of organs is more sufficient, the artificial interference factors such as the operation technology and the like are avoided, the expensive cost for establishing a large animal laboratory is avoided, and necessary conditions are created for the next step of large-scale and high-efficiency production, the experimental period is greatly shortened, the experimental cost is greatly reduced, and the interference factors are reduced.
Chinese patent application 201580002264.3 discloses a human body simulation device, comprising: an organ from an animal having a biological tissue and a blood vessel extending from the biological tissue; a blood reservoir portion for storing blood to be sent to the blood vessel; a tube connecting the blood vessel and the blood reservoir; a pump section provided in the middle of the tube and configured to transport blood from the blood reservoir section to the blood vessel; and a storage unit that stores the organ, humidifies the organ by supplying vapor having a temperature higher than room temperature to the organ, and sets the organ to a temperature of 20-50 ℃.
The basic structure of the prior art human body simulating device does not comprise an oxygenator and a thrombus filter, and a single organ is used, so that the simultaneous perfusion of multiple organs cannot be realized. Furthermore, this prior art technique achieves a unidirectional perfusion, whereas the organs of the body require a blood return circulation. Therefore, the organ mechanical perfusion device in the prior art is complex and heavy, and cannot realize multi-organ preservation, and multi-organ preservation cannot be realized.
SUMMERY OF THE UTILITY MODEL
In order to realize the clinical multi-organ isolated preservation, a multi-organ perfusion system taking the abdominal aorta or the thoracic aorta as the core must be established. In order to simplify the operation, the device of the utility model can simultaneously perfuse a plurality of organs or a single organ through the abdominal aorta or the thoracic aorta system through a single pump and a perfusion pipeline, wherein the portal vein of the liver does not need to be inserted with a tube, and the reflux perfusion is carried out by depending on the circulating perfusate through the intestinal artery system and the splenic artery; multiple thoracic organs can be perfused simultaneously through the thoracic aortic system, where the pulmonary arteries are perfused without cannulation with circulating perfusate from the right heart. In the case of preservation of multiple organs, only a single cannula is required, a significant simplification, which is a completely different basic principle than the prior art.
The utility model discloses an organ fills teaching training system, include:
organ storage: for receiving organs and collateral vessels of a living body;
a liquid storage bin: the organ bin is positioned below the organ bin and used for storing circulating perfusate;
temperature maintaining device: for maintaining the temperature of an organ of a living being;
filling a pipeline: connecting the liquid storage bin with an affiliated blood vessel of an organism organ, and pressurizing and circularly perfusing the organism organ and the affiliated blood vessel under the driving of a pump;
a pump: pressurizing the perfusion pipeline, and pressurizing and circularly perfusing the organism organ and the accessory blood vessel;
a display for displaying an operation image;
the base is used for supporting, moving and lifting the integral device;
the organ perfusion preservation device can pressurize and circularly perfuse the aorta system of a living body, and can perfuse single or multiple organs of the living body simultaneously.
Further, the organ perfusion preservation device can perfuse a plurality of abdominal organs simultaneously through an abdominal aorta system, wherein the portal vein of the liver does not need to be intubated, and perfusion is carried out through circulating perfusate reflowing through the portal vein system.
Further, the organ perfusion preservation device can perfuse a plurality of thoracic organs simultaneously through the thoracic aortic system, wherein the pulmonary artery is perfused without cannulation with circulating perfusate from the right heart.
Further, the system further comprises: an oxygenator: for continuously oxygenating the circulating perfusate; a thrombus filter: for filtering the circulating perfusion fluid.
Further, the system further comprises: and (4) covering: a temperature maintenance device for enclosing the organ chamber; a lifting column capable of adjusting the height of an operating platform, wherein the operating platform supports a housing and an upper cover; and the display bracket is used for supporting the display.
Further, the system further comprises: the abdomen bulge is arranged on the upper cover and used for simulating the human abdomen bulge, a minimally invasive instrument or an endoscope inlet and a digestive tract operation access are arranged on the abdomen bulge, the minimally invasive instrument or the endoscope inlet is used for a surgical minimally invasive surgical instrument to enter, and the digestive tract operation access is used for a digestive endoscope soft lens to enter.
Furthermore, the alimentary canal operation access comprises an esophagus inlet and a rectum inlet, wherein the esophagus inlet is used for the upper alimentary canal endoscope device to enter, and the rectum inlet is used for collecting the excretion waste or allowing the alimentary canal endoscope device to enter.
Further, an inner illuminating lamp is arranged in the belly swelling, and a miniature exhaust fan is arranged on the upper cover opposite to the belly swelling.
Further, a minimally invasive instrument universal arm fixing seat is arranged around the upper cover and used for fixing the universal support.
Further, the gimbal includes: the camera shooting device comprises a camera shooting rod fixing hole, a camera shooting rod fixing handle and a universal structure locking handle.
Further, the system further comprises: the temperature sensor is used for monitoring the temperature of the circulating perfusate and the organism organ 1 in the liquid storage bin; the flow sensor is used for monitoring the flow of the circulating perfusion liquid in the perfusion pipeline; and the pressure sensor is used for monitoring the pressure of the circulating perfusion liquid in the perfusion pipeline.
Further, the system further comprises: tablet pc host, tablet pc host) has: a basic information database for recording basic information of the operator; having an operational scoring system, the following parameters can be gathered for quantitative evaluation: bleeding volume, operation time, shivering degree and difficulty coefficient indexes; the video recording and storage system is used for recording the operation video and playing back the operation video; the network connection function is used for realizing the network connection and monitoring of the device; information can be displayed on the control panel and the display screen.
Further, the system further comprises: the controller is configured to collect signals of the temperature sensor, the flow sensor and the pressure sensor, and after analysis processing, the controller can perform the following control:
the rotating speed of the pump is controlled to prevent perfusion pressure or flow from being abnormal, so that the abnormal flow or perfusion pressure is avoided, and even organism organs are damaged;
controlling the oxygenator heating circulating pump and the temperature maintaining device to maintain the temperature of the organism organ and the perfusion pipeline, wherein the oxygenator heating circulating pump is used for pumping out hot water in the water bath box to circularly heat the oxygenator;
the height of the lifting column is controlled to adapt to operators with different heights; the brightness of an internal illuminating lamp is controlled, and the optimal brightness is provided for training operation;
controlling a filling pipeline clamping valve to adjust the opening and closing state of the filling pipeline in time; when the device is in an abnormal condition, the alarm device alarms in time;
the control panel and the display screen display the state of the controller and can manually adjust related parameters.
Furthermore, a diaphragm suspending structure is arranged in the organ cabin and used for suspending the diaphragm so as to simulate the normal anatomical position of the adjacent organ.
Further, a minimally invasive equipment bin, an oxygen cylinder, a bile collecting and metering device and/or a urine collecting and metering device are/is arranged on the base.
Compared with the prior art of the chinese patent application 201580002264.3, the utility model has the following differences: 1) the basic structure is different, the utility model discloses a device not only includes: organs and their connecting vessels, pump parts, tubes, heating devices, organ bins; also comprises an oxygenator, a thrombus filter and the like; 2) the pipeline structure of the device of the utility model is different from the Chinese patent application 201580002264.3, the utility model simultaneously fills abdominal cavity or thoracic cavity multiple organs through abdominal aorta or thoracic aorta system according to single pump and single blood vessel intubation, liver portal vein does not need intubation and depends on intestinal tract and spleen reflux perfusate for filling; the device can perfuse a plurality of thoracic organs simultaneously through a thoracic aorta system, wherein the pulmonary artery does not need to be cannulated and perfuses through the circulating perfusate of the right heart; 3) The utility model realizes blood reflux circulation, and Chinese patent application 201580002264.3 only adopts one-way perfusion, and does not mention circulation perfusion;
additionally, the beneficial effects of the utility model also include:
the utility model discloses a device is applicable to medical science wicresoft training (peritoneoscope, natural chamber way scope, operation robot, digestion scope etc.), utilizes the simple and convenient structure that single intubate aorta system circulation perfused many organs, utilizes the discarded big animal organ of slaughterhouse, in vitro perfusion preserves, utilizes blood or cell-free type circulation perfusate, the circulation is perfused supplementary energy substrate and is taken oxygen, maintain the organ vigor, and do not destroy the anatomical structure of abdominal cavity or thorax organ, help the doctor to master conventional operation or the basic operation of wicresoft technique. The method has the advantages of obviously reducing the cost, avoiding ethical problems, having anatomical variation, keeping a complete anatomical structure, keeping the vitality of organs, bleeding after injury and the like while approaching the effect of a large animal experiment to the maximum extent.
Drawings
Fig. 1 is a schematic plan view of the basic structure of the organ perfusion preservation device of the system of the present invention.
Fig. 2 is a schematic perspective view of the organ perfusion preservation apparatus of the system of the present invention.
Fig. 3 is a schematic diagram of the organ perfusion preservation apparatus of the system of the present invention.
Fig. 4 is a top view of an organ container of the organ perfusion preservation apparatus of the system of the present invention.
Fig. 5 is a top view of the core components of the organ perfusion preservation apparatus of the system of the present invention.
Fig. 6 is a side view of the core components of the organ perfusion preservation apparatus of the system of the present invention.
Fig. 7 is an exploded view of the core components of the organ perfusion preservation apparatus of the system of the present invention.
Fig. 8 is an overall appearance of the oxygenator and filter plug assembly of the system of the present invention.
Fig. 9 is a cross-sectional view of an oxygenator and plug filter assembly of the system of the present invention.
Fig. 10 is a right side perspective view of the entire system of the present invention.
Fig. 11 is a left side perspective view of the whole system of the present invention.
Fig. 12 is a top view of the system of the present invention.
Fig. 13 is a right side view of the system of the present invention.
Fig. 14 is an overall rear view of the system of the present invention.
Fig. 15 is an open, overall right side perspective view of the cover of the system of the present invention.
Fig. 16 is an open, overall left side perspective view of the upper cover of the system of the present invention.
Fig. 17 is an open top plan view of the system of the present invention.
Fig. 18 is a basic minimally invasive instrument access configuration of the system of the present invention.
Figure 19 shows the basic structure of the digestive endoscope inlet of the system of the present invention.
Fig. 20 shows the basic structure of the utility model system.
Figure 21 is the utility model discloses the pole gimbal schematic diagram of making a video recording of system
Fig. 22 is a schematic view of a bile and urine collection device of the system of the present invention.
Fig. 23 is a schematic diagram of the main structure of the rear part of the system of the present invention.
Fig. 24 is a schematic diagram of an electronic control system of the present invention.
Reference numerals
1-organism organ, 2-organ bin, 3-liquid storage bin, 4-temperature maintaining device, 5-oxygenator, 6-thrombus filtering device, 7-pump, 8-perfusion pipeline, 9-blood vessel intubation, 10-water bath box, 11-esophagus inlet, 12-digestive tract operation access, 13-rectum inlet, 14-diaphragm suspension, 16-bile collection and metering device, 17-urine collection and metering device, 18-camera rod fixing hole, 19-camera rod fixing handle, 20-universal structure locking handle, 21-power box, 22-diaphragm, 23-proximal abdominal aorta blocking ligature, 24-abdominal trunk, 25-splenic artery, 26-superior mesenteric artery, 27-distal abdominal aorta intubation ligature, 28-abdominal aorta, 29-superior and inferior hepatic vena cava, 30-liver, 31-intrinsic hepatic artery, 32-splenic vein, junction of superior mesenteric vein and portal vein, 33-renal artery, 34-inferior hepatic vena cava, 35-display, 36-display support, 37-abdominal bulge, 38-minimally invasive instrument or endoscope inlet, 38-1 screw cap, 38-2 silica gel sealing sheet, 38-3 screw base, 39-tablet computer host, 40-case shell, 41-micro exhaust fan, 42-temperature controller, 43-lifting column, 44-handle, 45-instrument hanging box, 45-1 instrument jack, 45-2 hook, 45-3 instrument box main body, 46-oxygen bottle, 47-knife cabin, 48-a minimally invasive equipment bin, 49-castors, 50-an oxygenator and embolectomy device bin, 51-an oxygen flow regulating meter, 52-a heater bin, 53-a minimally invasive instrument universal arm fixing seat, 54-an oxygenator and embolectomy device shell, 55-an upper cover, 56-an internal illuminating lamp, 57-an oxygen bottle bracket, 58-an organ bin shelf, 59-an organ bin fixing knob, 60-a backflow pipeline, 61-a base, 62-an upper cover hinge, 63-an oxygenator heating circulation interface, 64-a blood vessel intubation connecting part, 65-an oxygenator heater, 66-a flow sensor, 67-a controller, 68-a temperature sensor, 69-a pressure sensor, 70-a perfusion pipeline clamping valve, 71-an oxygenator heating circulation pump and 72-a spleen, 73-stomach, 74-intestinal tract, 75-kidney, 76-portal vein, 77-splenic vein, 78-superior mesenteric vein, 79-inferior mesenteric vein, 80-right gastroomentum vein, 81-inferior mesenteric artery, 82-low voltage DC power supply, 83-control panel and display screen, and 84-alarm device.
Detailed Description
Embodiments of the present invention will now be described with reference to the drawings, wherein like parts are designated by like reference numerals. The embodiments described below and the technical features of the embodiments may be combined with each other without conflict.
The core component of the system of the present invention is a mechanical perfusion preservation device for biological organs, which is described below with reference to fig. 1-9.
As shown in fig. 1 to 3, the device of the present invention is used for a living organism organ 1, the living organism organ 1 includes a living organism organ and a blood vessel attached from the living organism organ, and the living organism organ 1 may be an organ cluster or a single organ.
The device of the utility model is used for the mechanical perfusion to preserve organism organ 1, include: organ chamber 2, stock solution storehouse 3, temperature maintenance device 4, oxygenator 5, filter 6, pump 7 and perfusion circuit 8. Preferably, a vascular cannula 9 is included at the end of the perfusion circuit 8.
The organ container 2 is used for accommodating a living organ 1 and blood vessels attached from the living organ; the liquid storage bin 3 is positioned at the lower part of the organ bin 2 and is used for collecting circulating perfusate which flows back from the vein end of the organism organ; the temperature maintaining device 4 is used for maintaining the temperature of the organ bin 2, the liquid storage bin 3 and the whole device; the oxygenator 5 is used for oxygenating the circulating perfusate, and the oxygenator 5 is connected with an oxygen bottle 46; the thrombus filter 6 is used for filtering thrombus, bubbles and other impurities in the circulating perfusate; the pump 7 is used for maintaining the perfusion power of the device, pressurizing perfusion and circulating perfusion; the filling pipeline 8 is used for connecting each key component; the vessel cannula 9 is positioned at the end of the perfusion pipeline 8 and is connected with the aorta system of the organism organ 1 for pressurized perfusion and circulating perfusion. Preferably, the vascular cannula 9 has corresponding side holes in the aortic system at corresponding positions of the different branches, with an internal diameter matching it, allowing a more accurate perfusion of the corresponding organs. The vessel cannula 9 may also have multiple branches.
The portal vein 76 is perfused without cannulation, relying on the return perfusate from the splenic artery 25 to the spleen 72, and the return perfusate from the superior mesenteric artery 26 to the intestinal tract 74, after the splenic vein, superior mesenteric vein and portal vein junction 32 have merged.
As shown in fig. 2, the basic working principle of the device is as follows: the biological organ 1 is placed in the organ chamber 2, the temperature is maintained by the temperature maintaining device 4 outside the organ chamber 2 (the organ chamber 2 is placed in the temperature maintaining device 4), the circulating perfusate (including blood or non-cell type circulating fluid) flows back and is stored in the liquid storage chamber 3, and the liquid storage chamber 3 is positioned below the organ chamber 2. The organ chamber shelf 58 of the organ chamber 2 is provided with through holes, so that the organ chamber 2 and the liquid storage chamber 3 are physically communicated, and perfusate conveniently flows back to the liquid storage chamber 3 at the lower layer of the organ chamber after flowing out of the biological organ 1. In one embodiment (as shown in fig. 6 and 7), the temperature maintaining device 4 is in the form of a water bath 10, and not only can directly heat the organ chamber 2 immersed in the water bath 10, but also an oxygenator heating circulating pump 71 (disposed inside or outside the water bath 10) can pump out hot water in the water bath 10 to circularly heat the oxygenator 5, thereby improving heating efficiency. In another embodiment, the temperature maintaining device 4 is in the form of a compressor, ice, or ultra-low temperature agent, and maintains the low temperature of the liquid storage 3, the organ storage 2, and the living body organ 1 therein.
Under the drive of the pump 7, the circulating perfusion fluid in the liquid storage bin 3 enters the thrombus filter 6 to filter impurities and bubbles in the perfusion fluid; then oxygenated by an oxygenator 5; then enters the aorta system of the organism organ 1 in the organ chamber 2 through the perfusion pipeline 8 and the blood vessel intubation tube 9, and then perfuses a plurality of organs simultaneously by utilizing different branches of the aorta; finally, circulating perfusate and the like flow out through the vein end of the organism organ 1, are collected and refluxed and concentrated in the liquid storage bin 3, and thus form circulating perfusion in a reciprocating mode.
The circulation sequence is sequentially organism organ 1 in the organ chamber 2, liquid storage chamber 3, embolism filtering device 6, pump 7, oxygenator 5, perfusion pipeline 8 (blood vessel intubation tube 9) and organism organ 1 in the organ chamber 2. The filling line 8 connects the main components.
The utility model discloses an organ preservation device perfuses a plurality of organs simultaneously through abdominal aorta or thoracic aorta system, and wherein the portal vein 76 of liver need not the intubate, and the circulation perfusate of through portal vein system backward flow perfuses. Wherein the pulmonary artery is perfused by the circulating perfusate of the right heart without cannulation.
Optionally, a vessel cannula 9 is positioned at the end of the perfusion circuit 8 to connect to a collateral vessel of the biological organ 1 for perfusion.
Optionally, the vessel cannula 9 has corresponding side holes at corresponding positions of different branches in the aortic system, and the inner diameter is matched with the side holes, so that the corresponding organs can be perfused more accurately.
As shown in Figs. 1-3, in use of the device, first, a living organism organ 1 and its collateral vessels are placed in an organ chamber 2, all of which are arranged in a normal anatomical configuration. Then, both ends of the abdominal aorta 28 are respectively ligated by the proximal abdominal aorta occlusion ligature 23 and the distal abdominal aorta occlusion ligature 27, and the perfusion circuit 8 (optionally, the distal end is connected to the blood vessel cannula 9) is inserted into the abdominal aorta 28 and then fixed by the ligatures. The circulating perfusate is pressurized by the pump 7, injected into the abdominal aorta 28 through the perfusion line 8 (optionally with the end connected to the vessel cannula 9), and perfused through the organs through the abdominal aorta branches. Wherein bilateral kidneys 75 are perfused through renal artery 33; arterial perfusion of the liver 30 is performed through the celiac trunk 24 branching hepatic artery 31; and spleen 72 is perfused through celiac trunk 24 branch splenic artery 25; arterial infusion of the intestinal tract 74 through the superior mesenteric artery 26, the inferior mesenteric artery 81; the vein of the intestinal tract 74 returns to the superior mesenteric vein 78 and the inferior mesenteric vein 79, the vein of the spleen 72 returns to the splenic vein 77, and the vein of the stomach 73 returns to the right gastroomentum vein 80, and the splenic vein, the superior mesenteric vein and the portal vein junction 32 are converged together, and the liver is perfused through the portal vein 76, so the portal vein 76 can realize perfusion without a cannula. The device can complete perfusion of the abdominal cavity viscera only by perfusing the abdominal aorta 28 and the branches thereof through a single pipe. All the circulating perfusate flows back to the organ bin 2 and the liquid storage bin 3 through the suprahepatic vena cava 29 and the infrahepatic vena cava 34 of the inferior vena cava system, and then the circulating perfusate in the liquid storage bin 3 enters the thrombus filtering device 6 under the driving of the pump 7 to filter impurities and bubbles in the circulating perfusate; then oxygenated by an oxygenator 5; then enters the aorta system of the organism organ 1 in the organ chamber 2 through a perfusion pipeline 8 (optionally, the tail end is connected with a blood vessel cannula 9), and then perfuses a plurality of organs simultaneously by utilizing different branches of the aorta, and the steps are repeated in a circulating way;
the device can simultaneously perfuse a plurality of thoracic organs through a thoracic aortic system, wherein the pulmonary artery is perfused through the circulating perfusate of the right heart without intubation.
Optionally, a vessel cannula 9 is positioned at the end of the perfusion circuit 8 to connect to a collateral vessel of the biological organ 1 for perfusion.
Optionally, the vessel cannula 9 has corresponding side holes at corresponding positions of different branches in the aortic system, and the inner diameter is matched with the side holes, so that the corresponding organs can be perfused more accurately.
Optionally, the utility model discloses an animal organs such as pig or sheep are used to the device, and external machinery is perfused, resumes organ vigor, and human organ is simulated to the at utmost, carries out medical training.
Optionally, the utility model discloses a device can be used to external machinery and pours into human organ of preserving for many organs are preserved, play its key mutual guard action, preserve and restore simultaneously, aassessment organ vigor.
The structure and principles of the components of the organ chamber 2, the reservoir 3, the temperature maintenance device 4, the oxygenator 5 and the embolectomy filter 6 are further refined with reference to fig. 4-9. As shown in fig. 4, the bottom of the organ chamber 2 is provided with an organ chamber shelf 58, which is provided with a plurality of holes and is communicated with the lower liquid storage chamber 3 (see fig. 2) to facilitate the perfusion circulation liquid to flow back to the liquid storage chamber 3. The inner side of the organ chamber 2 is provided with a return pipeline 60, one end of the return pipeline 60 is communicated with the liquid storage chamber 3, and the other end is connected with the perfusion pipeline 8. Preferably, the bottom surface of the reservoir 3 is inclined toward the connection of the return line 60, so as to maintain a high liquid level, thereby facilitating collection of the circulating liquid and preventing the return line 60 from sucking air.
The outer wall of the water bath box 10 is provided with an oxygenator heating circulation interface 63, a circulating pump 71 is heated by the oxygenator for pumping warm water in the water bath box 10, and the circulating perfusate is heated by the oxygenator 5. The oxygenator heating cycle port 63 is not in communication with the organ chamber 2 and is in communication with the water bath 10 (described in detail below).
The side wall of the organ cabin 2 is provided with a diaphragm suspension 14 for suspending a diaphragm 22 (see fig. 1), the diaphragm suspension 14 is a protrusion protruding inwards from the inner wall of the organ cabin 2, and a plurality of diaphragm suspensions 14 can be arranged. The diaphragm hook 14 is used for fixing and hanging the diaphragm part of the organism organ 1, and restoring the anatomical position of the liver in the abdominal cavity to the maximum extent.
As shown in fig. 5-7, the device of the present invention comprises: organ chamber 2, water bath 10 (optional as temperature maintenance device 4), pump 7, oxygenator 5, embolectomy filter 6, return line 60, vessel cannula connection 64, and vessel cannula 9. Wherein, the return end of the perfusion pipeline 8 is connected with the return pipeline 60, the perfusion end is connected with the blood vessel intubation connecting part 64 and the blood vessel intubation 9, and the middle of the perfusion pipeline 8 is connected with the pump 7, the oxygenator 5, the thrombus filter 6 and other parts. The organism organ 1 is placed on an organ chamber shelf 58 in the organ chamber 2, and is immersed in the water bath box 10 together to maintain the body temperature environment, and the diaphragm hook 14 is used for fixing and hanging the diaphragm part of the organism organ 1, thereby reducing the anatomical position in the abdominal cavity to the maximum extent. Alternatively, the organ shelf 58 of the organ bin 2 may be made of metal as a negative plate of the high-frequency electric knife so as to use the high-frequency electric knife.
The circulating perfusate enters the abdominal aorta or thoracic aorta system of the organism organ 1 through the blood vessel cannula 9 under the pressurization driving of the pump 7, and perfuses a plurality of organs in the abdominal cavity or the thoracic cavity simultaneously, the portal vein 76 does not need to be cannulated, and depends on the reflux perfusate from the spleen artery 25 to the spleen 72, the superior mesenteric artery 26 perfusate the reflux perfusate of the intestinal tract 74, and the perfusion is performed after the spleen vein and the superior mesenteric vein are merged with the portal vein junction 32. The pulmonary artery is perfused with the circulating perfusate from the right heart without cannulation. Then the circulating perfusate flows out through the inferior vena cava of the organism organ 1 and intensively flows back to the liquid storage bin 3 at the lower part of the organ bin 2 through the porous structure of the organ bin shelf 58; then, under the drive of the pump 7, the circulating liquid in the liquid storage bin 3 is pumped out through the return pipeline 60 and flows to the thrombus filter 6, and thrombus and air embolism mixed in the circulating liquid are filtered; then passes through a pump 7 through a perfusion pipeline 8 through an outlet of the filter suppository device 6, and then enters the oxygenator 5 through the perfusion pipeline 8 to oxygenate the circulating liquid; then enters the blood vessel intubation connecting part 64 from the outlet of the oxygenator 5, and enters the blood vessel intubation 9 through the blood vessel intubation connecting part 64, thus completing the circulation perfusion process.
As shown in fig. 6 to 9, the organ chamber 2 and the reservoir chamber 3 are placed in the temperature maintenance apparatus 4, and the temperature maintenance apparatus 4 includes a water bath 10 and a temperature controller 42. The temperature is maintained through two ways, namely, the first way, warm water is contained in the water bath box 10 to directly heat the organ bin 2, the liquid storage bin 3 and the organism organ 1. In the second approach, the oxygenator heating circulation pump 71 is arranged to pump the warm water in the water bath 10 through the oxygenator heating circulation port 63 into the oxygenator heater 65, and the oxygenator heater 65 is located below the oxygenator 5 to heat the circulation liquid in the oxygenator 5.
The oxygenator 5 and the thrombus filter 6 are intensively arranged in the oxygenator and thrombus filter shell 54, and the corresponding perfusion pipelines 8 are regularly distributed in the shell 54, so that the oxygenator and thrombus filter is convenient to install and replace quickly; optionally, the components of the organ container 2, the reservoir 3, the oxygenator 5, the embolus filter 6, the perfusion line 8, the blood vessel cannula 9, the return line 60, etc. other than the pump 7 can be disposable, facilitating quick replacement.
Referring again to fig. 6, a temperature sensor 68 is disposed inside the organ cartridge 2 for monitoring the temperature of the living organism organ 1 inside the organ cartridge 2. Flow sensors 66 are disposed on the return line 60 and the vessel cannula connection 64 for monitoring the flow of the perfusion fluid circulating through the return line 60 and the vessel cannula connection 64. The pressure sensor 69 is arranged on the blood vessel intubation connecting part 64, wherein the blood vessel intubation 9 is connected with the tail end of the blood vessel intubation connecting part 64. The pressure sensor 69 is used to monitor the pressure at the vascular cannula connection 64, i.e. the pressure of the circulating perfusion fluid to be delivered to the vascular cannula 9.
Referring again to fig. 6, the organ perfusion preservation device of the present invention further includes a perfusion line clamp valve 70, which is disposed on the perfusion line 8, and is shown as being disposed near the input end of the pump 7, the perfusion line clamp valve 70 closes the circulation perfusion that can stop the perfusion line 8 quickly, and the organism organ 1 is prevented from being damaged when abnormal conditions occur.
The system of the present invention is described below with reference to fig. 10-24. The utility model discloses a system mainly used medical science wicresoft training (surgery peritoneoscope, natural chamber way scope, operation robot, internal medicine digestion scope etc.), utilize single intubate in the aorta system to perfuse the simple and convenient structure of multiple organs, utilize the big animal source organism organ 1 that the pig farm acquireed, perfuse the storage in vitro. The blood or cell-free circulating perfusate is used for supplementing energy substrates and oxygen, so that the vitality of organs is maintained, the anatomical structure of organs in the abdominal cavity or the thoracic cavity is not damaged, and doctors are helped to master the basic operation of the conventional operation or minimally invasive technique. The method has the advantages of obviously reducing the cost, avoiding ethical problems, having anatomical variation, keeping a complete normal anatomical structure, keeping the vitality of organs, bleeding after operation injury and the like while approaching the effect of a large animal experiment to the maximum extent.
As shown in fig. 10 to 17, the overall system structure of the present invention can be divided into three major parts, i.e., an upper half, a lower half, and a lifting column 43, wherein the upper half is a core component, and the lower half is mainly a base and main accessories. The upper half mainly comprises a chassis shell 40, an upper cover 55 and core components located inside the chassis shell and the upper cover: a biological organ 1, an organ chamber 2, a water bath 10, a pump 7, an oxygenator 5, a thrombus filter 6, a perfusion line 8, a reflux line 60, a blood vessel intubation tube connection part 64, a blood vessel intubation tube 9, and the like. In addition, the upper half part is also provided with a display 35, a display bracket 36 for supporting the display 35, an abdominal bulge 37, a minimally invasive instrument or endoscope inlet 38, a tablet personal computer host 39, a water bath tank temperature controller 42, an instrument hanging box 45 and the like. The cabinet housing 40 is provided with a heater chamber 52 therein for accommodating the water bath cabinet 10.
The display 35 is used for displaying operation images or other operation information, and the display content of the display 35 is from operation images transmitted by a laparoscope or a digestive endoscope host in the minimally invasive device bin 48, or operation teaching videos transmitted by the tablet personal computer host 39. An abdominal distension 37 is provided on the upper cover 55, the abdominal distension 37 including but not limited to a circle, an ellipse, etc., the abdominal distension 37 being used to simulate the abdominal or laparoscopic pneumoperitoneum condition of the body. A minimally invasive instrument or endoscope inlet 38 is provided on the abdominal distension 37 for receiving a laparoscopic instrument or endoscope hose. An internal illumination lamp 56 is provided within the abdominal distension 37 for illumination during operation. The organ chamber fixing knob 59 is used for fastening the organ chamber 2, fastening the organ chamber 2 to the water bath tank 10, and preventing the floating of the organ chamber 2 caused by the warm water buoyancy in the water bath tank 10 below the organ chamber 2. A handle 44 is provided at the front lower part of the case housing 40 for hanging an instrument hanging box 45, and the instrument hanging box 45 is used for accommodating training instruments for standby.
A minimally invasive instrument universal arm fixing seat 53 is arranged around the upper cover 55, is used for fixing a universal bracket (comprising a camera shooting rod fixing hole 18, a camera shooting rod fixing handle 19 and a universal structure locking handle 20, as shown in fig. 21), is used for adjusting and fastening a camera shooting rod of a minimally invasive device, is convenient for single-person operation, and replaces an assistant; at the front end of the upper cover 55, a micro exhaust fan 41 is provided toward the abdominal bulge 37, and the micro exhaust fan 41 is used for exhausting the steam generated by the evaporation of the organ chamber 2 and the water bath box 10 and the smoke generated by the cauterization of the organism organ 1 by the high frequency electric knife in the operation. The upper cover 55 has an upper cover hinge 62 that can be opened and closed by rotation.
The tablet personal computer host 39 is provided with a basic information database for recording basic information of an operator; there is an operational scoring system that can gather the following parameters for evaluation: bleeding amount, operation time, shivering degree, difficulty coefficient and the like. The tablet pc host 39 has a recording and storage system for recording and playing back the operation video. The tablet computer host 39 has a network connection function to implement device networking. The tablet pc host 39 may also be connected to an electronic control system having the functions of a control panel and a display screen 83, as described in the second section.
The lower half part mainly takes a base 61 as a core, a plurality of casters 49 are symmetrically distributed on the periphery of the base 61, a minimally invasive equipment bin 48 and an electric knife bin 47 are arranged on the upper part of the base 61, and an oxygen cylinder 46 is arranged at the rear part of the base 61. Wherein, the minimally invasive equipment bin 48 is used for accommodating a laparoscope or a digestive endoscope host, and the electric knife bin 47 is used for accommodating a high-frequency electric knife. The oxygen cylinder 46 is used for supplying oxygen and is placed on the oxygen cylinder bracket 57, and an oxygen flow regulating meter 51 is arranged at the outlet of the oxygen cylinder 46 and is used for regulating the gas outlet amount of the oxygen cylinder 46. The height of the lifting column 43 can be adjusted, and the height of the operation surface of the machine can be adjusted to adapt to different heights of operators.
As shown in fig. 15-17, the upper cover 55 has a hinge 62 for opening and closing the upper cover in a rotatable manner, so as to facilitate the opening of the upper cover 55 and the quick replacement of consumables such as the organ container 2, the oxygenator 5, and the thrombus filter 6; the abdominal distension 37 is internally provided with an internal illuminating lamp 56. The organ chamber fixing knob 59 is used to fasten the organ chamber 2, fasten the organ chamber 2 with the water bath 10, prevent buoyancy from causing the organ chamber 2 to float, and maintain a sufficient contact area to improve heat conduction efficiency. The pump 7 is fixed inside the casing 40, and the oxygenator 5 and the filter 6 are collectively placed in the same casing 54 and fixed inside the casing 40.
As shown in fig. 18, the upper cover 55 has a minimally invasive instrument or endoscope entrance 38, which is mainly used for a camera rod for laparoscopic training and a surgical minimally invasive surgical instrument to enter for training. The minimally invasive instrument or endoscope inlet 38 comprises: a screw cap 38-1, a silica gel sealing sheet 38-2 and a screw base 38-3. The screw cap 38-1 secures the silicone sealing disc 38-2 to the screw base 38-3, not only to seal the upper cover, but also to simulate a minimally invasive instrument penetration.
As shown in fig. 19, the upper cover 55 has an alimentary canal operation access 12, which includes an esophageal entrance 11 and a rectal entrance 13, and mainly simulates the structure of human esophagus and anus for the digestive endoscopy soft lens to enter for training the digestive endoscopy. Preferably includes an esophageal portal 11 for access by devices such as gastroscopes and the like, upper gastrointestinal endoscopes and the like; preferably comprising a rectal inlet 13 for collecting faecal waste, or for entry of an endoscopic device for the digestive tract, such as a colonoscope.
As shown in fig. 20, the instrument hanging box 45 includes: an instrument jack 45-1, a hook 45-2 and an instrument box main body 45-3. Wherein, the main body 45-3 of the instrument box is of a hollow structure, the side surface is provided with an instrument jack 45-1 and a hook 45-2, and the hook 45-2 extends out vertical to the main body of the instrument box. The instrument hanging box 45 can be hung on the handle 44 in front of the teaching and training device through the hook 45-2.
As shown in fig. 21, the camera mast gimbal includes a camera mast fixing hole 18, a camera mast fixing handle 19, and a gimbal structure locking handle 20. The camera shooting rod fixing hole 18 is used for accommodating a camera shooting rod of a minimally invasive device, the camera shooting rod fixing handle 19 is used for locking the camera shooting rod, and the universal structure locking handle 20 is used for adjusting and locking a universal structure, so that the camera shooting rod is convenient to operate by a single person and replaces an assistant;
as shown in fig. 22, the system of the present invention further has a bile collecting and metering device 16 and a urine collecting and metering device 17 for collecting bile and urine and dynamically observing the vitality of the organs. The bile collecting and metering device 16 and the urine collecting and metering device 17 are arranged on the side surface of the case shell 40.
The system of the present invention further includes an electronic control system, the power supply of which relies on a low voltage dc power supply 82 located in the power supply box 21 (see fig. 23). The power supply box 21 is located at the rear of the chassis housing 40.
As shown in fig. 24, the core of the electronic control system of the present invention is the controller 67, and the electronic control system includes the controller 67, the control panel and the display screen 83. Fig. 24 shows a schematic circuit diagram of the electronic control system. After the signals of the temperature sensor 68, the flow sensor 66 and the pressure sensor 69 are transmitted to the controller 67 for analysis, the controller 67 controls the temperature of the temperature maintaining device 4, controls the rotation speed of the pump 7 to prevent the perfusion pressure or flow from being abnormal, controls the open/close state of the perfusion line clamp valve 70, and gives an alarm in time through the alarm device 84 when the device is abnormal.
The controller 67 is located near the power box 21, and the controller 67 collects signals of the temperature sensor 68, the flow sensor 66 and the pressure sensor 69, and after analysis processing, can perform the following control: 1) controlling the rotation speed of the pump 7 to prevent perfusion pressure or flow from being abnormal, avoid or prevent the flow from being abnormal and even damage the organism organ 1; 2) controlling the oxygenator heating circulation pump 71 and the temperature maintaining device 4 to maintain the temperature of the living organ 1 and the perfusion circuit 8; 3) the height of the lifting column 43 is controlled to adapt to operators with different heights; 4) the brightness of the internal illuminating lamp 56 is controlled, and the optimal brightness is provided for training operation; 5) controlling the filling pipeline clamping valve 70 to adjust the opening and closing state of the filling pipeline 8 in time; 6) the alarm device 84 gives an alarm in time when an abnormal condition occurs in the apparatus. The control panel and display 83 is used to display the status of the controller 67 and can manually adjust the relevant parameters.
The above-mentioned embodiments are only preferred embodiments of the present invention, and the ordinary changes and substitutions performed by those skilled in the art within the technical scope of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. An organ perfusion teaching and training system, comprising:
organ cartridge (2): for receiving organs (1) of a living being and accessory blood vessels;
liquid storage bin (3): the device is positioned below the organ bin (2) and used for storing circulating perfusate;
temperature maintaining device (4): for maintaining the temperature of an organ (1) of a living being;
priming line (8): the liquid storage bin (3) and the subsidiary vessel of the organism organ (1) are connected, and the organism organ (1) and the subsidiary vessel are pressurized and circularly perfused under the driving of a pump (7);
pump (7): pressurizing a perfusion pipeline (8) to pressurize and circularly perfuse the organism organ (1) and the accessory blood vessel;
a display (35) for displaying an operation image;
a base (61) for supporting, moving and lifting the integrated device;
upper cover (55): a device (4) for sealing the organ chamber (2) and maintaining the temperature;
a lifting column (43), the lifting column (43) being capable of adjusting the height of an operating platform, wherein the operating platform supports a housing (40) and an upper cover (55);
a display stand (36) for supporting a display (35);
oxygenator (5): for continuously oxygenating the circulating perfusate;
thrombus filter (6): for filtering the circulating perfusate;
the organ perfusion preservation device is used for pressurizing and circularly perfusing the aorta system of a living body, and perfusing a plurality of organs (1) of the living body singly or simultaneously.
2. The system of claim 1, further comprising:
the abdomen bulge (37), the abdomen bulge (37) sets up on upper cover (55) for simulate human abdomen bulge, have wicresoft's apparatus or scope entry (38), alimentary canal operation access (12) on abdomen bulge (37), wicresoft's apparatus or scope entry (38) supply surgery wicresoft's operation apparatus to get into, and alimentary canal operation access (12) supply the soft mirror of digestion scope to get into.
3. The system of claim 2,
the alimentary canal operation access way (12) comprises an esophagus inlet (11) and a rectum inlet (13), wherein the esophagus inlet (11) is used for the upper alimentary canal endoscope device to enter, and the rectum inlet (13) is used for collecting the excretion waste or allowing the alimentary canal endoscope device to enter.
4. The system of claim 2,
an internal illuminating lamp (56) is arranged in the abdomen bulge (37), and a micro exhaust fan (41) is arranged on the upper cover (55) opposite to the abdomen bulge (37).
5. The system of claim 1,
a minimally invasive instrument universal arm fixing seat (53) is arranged around the upper cover (55) and used for fixing a universal bracket.
6. The system of claim 5, wherein the gimbal comprises:
a camera shooting rod fixing hole (18), a camera shooting rod fixing handle (19) and a universal structure locking handle (20).
7. The system of claim 1, further comprising:
the temperature sensor (68) is used for monitoring the temperature of the circulating perfusate and the organism organ (1) in the liquid storage bin (3);
a flow sensor (66) for monitoring the flow of the circulating perfusion fluid in the perfusion line (8);
a pressure sensor (69) for monitoring the pressure of the circulating perfusion fluid in the perfusion line (8).
8. The system of claim 1,
a diaphragm suspending structure (14) is arranged in the organ cabin (2) and used for suspending a diaphragm (22) so as to simulate the normal anatomical position of an adjacent organ.
9. The system of claim 1,
the base (61) is provided with a minimally invasive equipment bin (48), an oxygen bottle (46), a bile collecting and metering device (16) and/or a urine collecting and metering device (17).
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| CN2019102243301 | 2019-03-22 | ||
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| CN201921443568.5U Active CN211294426U (en) | 2019-03-22 | 2019-09-02 | Organ perfusion teaching and training system |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110459113A (en) * | 2019-03-22 | 2019-11-15 | 天一阁医疗科技(广州)有限公司 | A kind of organ perfusion's teaching and training system |
| CN112772632A (en) * | 2020-12-31 | 2021-05-11 | 重庆北部宽仁医院 | Isolated liver perfusion device |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110859178B (en) * | 2019-12-23 | 2022-04-22 | 张嘉 | MRI (magnetic resonance imaging) -compatible in-vitro kidney perfusion system |
| CN114373347A (en) * | 2020-12-15 | 2022-04-19 | 西安赛德欧医疗研究院有限公司 | Intelligent high-simulation training system for whole-organ surgery |
| CN113487953B (en) * | 2021-07-30 | 2023-05-05 | 北京博医时代教育科技有限公司 | Esophageal gastric fundus varices operation training model and manufacturing method thereof |
| CN113793545A (en) * | 2021-10-12 | 2021-12-14 | 北京博医时代教育科技有限公司 | Operation simulation device and operation training system |
| CN215868358U (en) * | 2021-10-12 | 2022-02-18 | 北京博医时代教育科技有限公司 | Training is with filling platform |
| CN113994954A (en) * | 2021-12-10 | 2022-02-01 | 广东省虚拟医学科技有限公司 | Organ in-vitro perfusion device |
| CN115394163B (en) * | 2022-08-23 | 2024-04-02 | 南方医科大学 | Isolated organ perfusion simulation device and method |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995444A (en) * | 1974-11-08 | 1976-12-07 | American Hospital Supply Corporation | Organ perfusion system |
| GB201119420D0 (en) * | 2011-11-10 | 2011-12-21 | Organox Ltd | Oxygen supply for organ perfusion systems |
| CN202694653U (en) * | 2012-05-02 | 2013-01-23 | 上海理工大学 | Multipurpose laparoscopic surgery trainer |
| ES2388223B1 (en) * | 2012-06-29 | 2013-09-02 | Grifols Sa | Device for perfusion of a liver graft |
| CN103886796B (en) * | 2014-03-13 | 2016-02-24 | 西安交通大学 | A kind of for the organ perfusion's system in surgical simulation training aids |
| IL303658B1 (en) * | 2014-06-02 | 2024-03-01 | Transmedics Inc | Ex vivo organ care system |
| CN104430302B (en) * | 2014-12-04 | 2016-05-18 | 宋涂润 | For preserving the normal temperature filling system of human organ |
| CN104705288B (en) * | 2015-02-16 | 2016-09-07 | 杭州电子科技大学 | Subnormal temperature transplant organ vitro intelligent supports System and method for |
| US11785938B2 (en) * | 2016-07-22 | 2023-10-17 | Eth Zurich | Perfusion loop assembly for an ex-vivo liver perfusion and a liver chamber assembly |
| CN108719271A (en) * | 2017-04-13 | 2018-11-02 | 南方医科大学珠江医院 | Isolated organ Perfusion preservation movement system |
| CN108432743B (en) * | 2018-06-15 | 2023-08-11 | 广东丁沃生医疗器械有限公司 | Portable organ donation donor mechanical perfusion system |
| CN110459113A (en) * | 2019-03-22 | 2019-11-15 | 天一阁医疗科技(广州)有限公司 | A kind of organ perfusion's teaching and training system |
| CN110432260A (en) * | 2019-03-22 | 2019-11-12 | 天一阁医疗科技(广州)有限公司 | A kind of machine perfusion save set of organism organ |
-
2019
- 2019-09-02 CN CN201910822478.5A patent/CN110459113A/en active Pending
- 2019-09-02 CN CN201921443568.5U patent/CN211294426U/en active Active
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110459113A (en) * | 2019-03-22 | 2019-11-15 | 天一阁医疗科技(广州)有限公司 | A kind of organ perfusion's teaching and training system |
| CN112772632A (en) * | 2020-12-31 | 2021-05-11 | 重庆北部宽仁医院 | Isolated liver perfusion device |
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| Publication number | Publication date |
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| CN110459113A (en) | 2019-11-15 |
| WO2020192511A1 (en) | 2020-10-01 |
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Effective date of registration: 20210514 Address after: No.2 Xiangshan Avenue, Ningxi street, Zengcheng District, Guangzhou, Guangdong 510000 Patentee after: Singularity medical technology (Guangzhou) Co., Ltd Address before: 510075 room a40, 505, west block, 2 Shuiyin Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee before: Tianyige medical technology (Guangzhou) Co.,Ltd. |