CN211271342U - Vascular clamp for ischemia reperfusion rat and mouse model - Google Patents
Vascular clamp for ischemia reperfusion rat and mouse model Download PDFInfo
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- CN211271342U CN211271342U CN201922012837.9U CN201922012837U CN211271342U CN 211271342 U CN211271342 U CN 211271342U CN 201922012837 U CN201922012837 U CN 201922012837U CN 211271342 U CN211271342 U CN 211271342U
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- clamp
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- vascular clamp
- sleeve
- blood vessel
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Abstract
The utility model discloses a vascular clamp for ischemia reperfusion rat and mouse models, which comprises a vascular clamp and a vascular clamp split device, wherein the vascular clamp comprises a first clamp part and a second clamp part which have the same structure, the first clamp part and the second clamp part are mutually crossed and fixedly connected through a universal driving shaft, one ends of the first clamp part and the second clamp part are mutually parallel, and a spring is fixedly connected between the first clamp part and the second clamp part which are mutually parallel; the blood vessel presss from both sides the components of a whole that can function independently device and includes two blood vessel clamp sleeve pipes that the structure is the same, and two blood vessel clamp sleeve pipes overlap respectively in the one end that first clamp part and second clamp part are parallel to each other, all are equipped with the blood vessel and press from both sides the components of a whole that can function independently in two blood vessel clamp sleeve pipes. The vascular clamp and the vascular clamp are connected in a split way, and the vascular clamp sleeve extends out of the body to carry out abdominal cavity or thoracic cavity suture after animal surgery, so as to carry out postoperative treatment. The vascular clamp is separated and inserted into the socket at the tail part of the vascular clamp along the vascular clamp pipe sleeve, the vascular clamp is removed, and the problem of the increase of the death rate of animals caused by the fact that the abdominal opening is performed by secondary anesthesia or the thoracic opening is performed to take out the vascular clamp is avoided.
Description
Technical Field
The utility model belongs to the technical field of biomedicine, concretely relates to a vascular clamp for ischemia reperfusion rat and mouse model.
Background
With the rapid development of medical technology, organ transplantation has become an important treatment for severe organ failure and end-stage tumors. Ischemia-reperfusion injury (ischemia-reperfusion injury) is an important influencing factor for the success rate and survival rate of organ transplantation patients such as heart transplantation and liver transplantation. How to prevent and treat ischemia-reperfusion injury is a hotspot direction of modern organ transplantation research, and a rat animal model of ischemia-reperfusion is the most common animal model for researching ischemia-reperfusion injury in recent years. The general ischemia reperfusion animal model adopts a rat and mouse anesthesia laparotomy operation, cuts off ischemia for 60-90 minutes by using a vascular clamp cutting off mode, removes the vascular clamp for perfusion for 1-2 hours, and the rat and the mouse are always in an anesthesia laparotomy or thoracotomy state in the period, so that the rat and the mouse are easy to die, and the acute ischemia reperfusion rat and mouse animal model can be generally constructed only. How to complete abdominal cavity or thoracic cavity suture of the big mouse as soon as possible after abdominal cavity or thoracotomy for ischemia, remove the vascular clamps at the set time to recover blood flow, improve the survival rate of the big mouse and the small mouse, and construct a chronic ischemia reperfusion big mouse model has important significance for researching and preventing ischemia reperfusion injury and improving the survival rate of patients after organ transplantation operation and resection.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a vascular clamp for ischemia reperfusion rat and mouse model can realize the accurate butt joint of internal vascular clamp and the external vascular clamp components of a whole that can function independently, and does not harm the tissue organ.
The technical scheme adopted by the utility model is that the vascular clamp for the ischemia reperfusion rat and mouse model comprises a vascular clamp and a vascular clamp split device, wherein the vascular clamp comprises a first clamp part and a second clamp part which have the same structure, the first clamp part and the second clamp part are mutually crossed and fixedly connected through a universal driving shaft, one ends of the first clamp part and the second clamp part are mutually parallel, and a spring is fixedly connected between the first clamp part and the second clamp part which are mutually parallel;
the blood vessel presss from both sides the components of a whole that can function independently device and includes two blood vessel clamp sleeve pipes that the structure is the same, and two blood vessel clamp sleeve pipes overlap respectively in the one end that first clamp part and second clamp part are parallel to each other, all are equipped with the blood vessel and press from both sides the components of a whole that can function independently in two blood vessel clamp sleeve pipes.
The utility model is also characterized in that,
the inside of each sleeve is also provided with a link joint, and the vascular clamp split bodies are respectively and fixedly connected with the first clamp part and the second clamp part through the link joints.
The link ends of the links are of a hexagonal structure.
The vascular clamp components of a whole that can function independently is hexagon cylinder formula structure, and the hexagon size of chain joint suits with the hexagon size of vascular clamp components of a whole that can function independently, and the afterbody of vascular clamp components of a whole that can function independently is spherical setting.
One end of the first clamping part and one end of the second clamping part, which are far away from the sleeve, are both provided with vascular clamp front parts.
The front part of the vascular clamp is provided with a spherical chuck.
Also included is a sleeve closure insertable inside the jacketed vascular tube.
The sleeve closing body is a cylindrical structure, and the outer diameter of the sleeve closing body is matched with the inner diameter of the blood vessel jacket sleeve.
The sleeve is a hollow tubular structure made of PP, PE or TPE materials.
The utility model has the advantages that: the utility model discloses a blood vessel jacket sleeve pipe (PP, PE or PET that high temperature resistant, can disinfect) is connected blood vessel jacket and blood vessel jacket components of a whole that can function independently device, and it is external to make the blood vessel jacket sleeve pipe extend the animal after the animal operation, carries out abdominal cavity or thorax and sews up, carries out positive postoperative treatment to big mouse. At the required time point, the vascular clamp split body is inserted into the tail socket of the vascular clamp along the vascular clamp pipe sleeve, the vascular clamp is removed, and the vascular clamp is taken out from the pipe sleeve opening, so that the problem of improvement of the animal mortality caused by opening the abdomen or opening the chest to take out the vascular clamp in secondary anesthesia is solved. Particularly, in the construction process of the chronic ischemia reperfusion rat model, the survival rate of the modeling animal is improved, and the problems of high mortality rate of the animal and difficulty in modeling caused by secondary abdomen opening or thoracotomy and vascular clamp taking out in the chronic ischemia reperfusion rat model are solved.
Drawings
FIG. 1 is a schematic structural diagram of a vascular clamp for ischemia reperfusion rat and mouse models according to the present invention;
FIG. 2 is a schematic structural view of the vascular clamp of the present invention;
FIG. 3 is a front view of the link joint connection end of the present invention;
FIG. 4 is a schematic structural view of the sleeve closure of the present invention;
FIG. 5 is a schematic view of the insertion of the inventive cannula closure into a vascular clamping cannula;
in the figure, 1, a first clamping part, 2, a second clamping part, 3, a vascular clamp front part, 4, a link joint, 5, a vascular clamp sleeve, 6, a vascular clamp split body, 7, a spring, 8, a sleeve closing body and 9, a linkage shaft.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings and specific embodiments.
As shown in fig. 1, for the utility model relates to a structural schematic diagram of a vascular clamp for ischemia reperfusion rat model, including vascular clamp and vascular clamp components of a whole that can function independently device, vascular clamp components of a whole that can function independently device is shown as the dotted line part in fig. 1, and the vascular clamp includes the same first clamp 1 of structure and second clamp 2, and first clamp 1 and second clamp 2 intercross just pass through universal driving shaft 9 rigid coupling, and the one end of first clamp 1 and second clamp 2 is parallel to each other, and the rigid coupling spring 7 that still goes between first clamp 1 and the second clamp 2 that are parallel to each other.
The blood vessel clamp split device comprises two blood vessel clamp sleeves 5 with the same structure, the two blood vessel clamp sleeves 5 are respectively sleeved at one end of the first clamping part 1 and one end of the second clamping part 2 which are parallel to each other, blood vessel clamp split bodies 6 are respectively arranged in the two blood vessel clamp sleeves 5, as shown in fig. 2, the blood vessel clamp split bodies 6 are of a hexagonal column structure, the tail parts of the blood vessel clamp split bodies 6 are arranged in a spherical mode, a link joint 4 is further arranged inside each blood vessel clamp sleeve 5, the connecting end of the link joint 4 is of a hexagonal structure, the size of the hexagonal link joint 4 is matched with that of the hexagonal blood vessel clamp split body 6, the hexagonal structure of the link joint 4 is shown in fig. 3, the blood vessel clamp split bodies 6 are respectively fixedly connected with the first clamping part 1 and the second clamping part 2 through the link joint 4, and the blood vessel clamp split device further comprises a sleeve closing body.
The hexagon of the vessel clamp split body 6 column body is matched with the hexagon shape of the link joint 4, so that the vessel clamp split body 6 can be connected with the first clamping part 1 and the second clamping part 2 through the link joint 4.
One ends of the first clamping part 1 and the second clamping part 2, which are far away from the vascular clamping sleeve 5, are provided with vascular clamp front parts 3, and the vascular clamp front parts 3 are spherical clamping heads.
The vascular clamp sleeve 5 is made of high-temperature-resistant and sterilizable elastic materials, and the vascular clamp sleeve 5 is of a hollow tubular structure made of PP (polypropylene), PE (polyethylene) or TPE (thermoplastic elastomer).
The sleeve closing body 8 is a cylindrical structure, and the outer diameter of the sleeve closing body 8 is matched with the inner diameter of the vascular clamp sleeve 5.
Except the blood vessel clamp sleeve 5, the other parts of the utility model are stainless steel structures.
The utility model discloses a theory of operation is: because the vascular clamp sleeve 5 is made of high-temperature-resistant, sterilizable and elastic materials, the spring 7 is compressed by pressing the front section and the rear section of the link joint 4 by utilizing the lever principle, the first clamp part 1 and the second clamp part 2 are partially opened by the universal driving shaft 9, the front section and the rear section of the link joint 4 are loosened, the spring 7 naturally resets, and the first clamp part 1 and the second clamp part 2 are partially closed by the universal driving shaft 9. The vascular clamp sleeve 5 adopts a hollow tubular structure, so that the vascular clamp split body 6 and the link joint 4 are protected from accurately abutting and damaging tissues and organs in a body. The hexagonal notch of the vascular clamp tail link joint 4 is in butt joint with the vascular clamp split body 6, after the butt joint is completed, the vascular clamp split body 6 becomes a vascular clamp tail extension part, the mode of opening and closing the vascular clamp in the previous period is the same, the tail part of the vascular clamp split body 6 is pressed or loosened, the spring 7 is compressed or reset, and the blood first clamping part 1 and the blood second clamping part 2 are opened and closed through the universal driving shaft 9. The cylindrical sleeve closing body 8 can be directly inserted into the hollow vascular clamp sleeve 5 to prevent external bacteria from entering the animal body through the sleeve, and fig. 5 is a structural schematic diagram of the sleeve closing body 8 inserted into the vascular clamp sleeve 5.
The utility model relates to a use method that is used for ischemia reperfusion rat and mouse model's vascular clamp does: before operation, the internal part of the stainless steel vascular clamp (dotted line in figure 1) is sleeved on a sleeve 5 at the tail part of the vascular clamp according to the animal and the operation condition. Animal anesthesia, get the supine position, open abdominal cavity or thorax, it needs to block the blood vessel to expose, get the utility model discloses the vascular clamp, press the front and back section of vascular clamp afterbody chain joint 4 with thumb and forefinger, vascular clamp spring 7 partial compression, make first clamp 1 and 2 sections of second clamp open, make and need to block the blood vessel and be in the vascular clamp mouth, the front and back section of the chain joint 4 of unclamping the vascular clamp afterbody is in order to clip the blood vessel, test stainless steel vascular clamp internal part (dotted line part in figure 1) sheathes in vascular clamp sleeve pipe 5 and whether firm, and test afterbody vascular clamp sleeve pipe 5 stretches out the external position of animal, the vascular clamp afterbody should be as far as possible and the sleeve pipe stretches out the position and be the straight line, make things convenient for external vascular clamp components of a whole that can function independently 6. The abdominal cavity or the thoracic cavity is sutured, the part of the tail blood vessel jacket 5 extending out of the body is sealed by a cylindrical external jacket closing body 8 or a thread tie, and external bacteria are prevented from entering the body of the animal through the jacket. The hexagonal cylinder type external vascular clamp split 6 adopts a hexagonal cylinder mechanism and a spherical tail part. After a specified time, the animals were anesthetized with a small dose and placed in supine position. And taking out the cylindrical external sleeve closing body from the tail sleeve of the vascular clamp or removing the wire tie. The blood vessel clamp split body 6 is externally connected with a hexagonal cylinder type and enters along a blood vessel clamp tail sleeve 5, the blood vessel clamp split body 6 enters into a blood vessel clamp tail link joint 4, the spherical tail part of the blood vessel clamp split body 6 is pressed by a thumb and an index finger, the spring 7 is partially compressed, the first clamp part 1 and the second clamp part 2 are partially expanded, and the blood vessel clamp is removed from a blood vessel. The other clip is slowly taken out of the animal body by pinching the tail sleeve 5 of the vascular clamp. The laparotomy or thoracotomy tube removal is optionally sutured or not sutured. The used device is put into a cleaning machine, and is sterilized under high pressure after being cleaned, so that the device can be repeatedly used.
The utility model discloses can realize ischemia reperfusion rat model operation vascular clamp and can sew up abdominal cavity or thorax after blocking the blood vessel, later stage removes the vascular clamp from external and resumes the blood flow, has improved ischemia reperfusion rat model's moulding rate, is suitable for chronic ischemia reperfusion rat model and founds. By utilizing the sleeve structure, the blood vessel clamp in vivo and the blood vessel clamp in vitro can be accurately butted in a split way without damaging tissues and organs. The ball-type chuck is adopted, the force of the vascular clamp on the blood vessel can be controlled by the ball-type chuck, and the blood vessel is blocked by the columnar clamp body, so that the risk of the common flat vascular clamp for clamping and breaking the blood vessel is prevented.
Claims (9)
1. The vascular clamp for the ischemia reperfusion rat model is characterized by comprising a vascular clamp and a vascular clamp splitting device, wherein the vascular clamp comprises a first clamp part (1) and a second clamp part (2) which are identical in structure, the first clamp part (1) and the second clamp part (2) are mutually crossed and fixedly connected through a universal driving shaft (9), one ends of the first clamp part (1) and the second clamp part (2) are mutually parallel, and a spring (7) is fixedly connected between the first clamp part (1) and the second clamp part (2) which are mutually parallel;
the vascular clamp split device comprises two vascular clamp sleeves (5) with the same structure, the two vascular clamp sleeves (5) are respectively sleeved at one ends of the first clamp part (1) and the second clamp part (2) which are parallel to each other, and vascular clamp split bodies (6) are arranged in the two vascular clamp sleeves (5).
2. The vascular clamp for the ischemia reperfusion rat and mouse model is characterized in that a link joint (4) is further arranged inside each vascular clamp sleeve (5), and the vascular clamp split bodies (6) are fixedly connected with the first clamp part (1) and the second clamp part (2) through the link joint (4) respectively.
3. The vascular clamp for the ischemia reperfusion rat and mouse model as claimed in claim 2, wherein the connecting end of the link joint (4) is a cylindrical hexagon.
4. The vascular clamp for the ischemia reperfusion rat model as claimed in claim 3, wherein the vascular clamp split body (6) is a hexagonal column structure, the hexagonal size of the link joint (4) is adapted to the hexagonal size of the vascular clamp split body (6), and the tail part of the vascular clamp split body (6) is arranged in a spherical shape.
5. The vascular clamp for the ischemia reperfusion rat model is characterized in that the ends of the first clamp part (1) and the second clamp part (2) far away from the vascular clamp sleeve (5) are provided with vascular clamp front parts (3).
6. The vascular clamp for the rat model of ischemia-reperfusion according to claim 5, characterized in that the front part (3) of the vascular clamp is a ball chuck.
7. A vascular clamp for ischemia reperfusion rat and mouse models according to claim 1, wherein the vascular clamp split device further comprises a sleeve closing body (8) insertable inside the vascular clamp sleeve (5).
8. A vascular clamp for use in a rat model of ischaemia-reperfusion as claimed in claim 7, wherein the sleeve closure body (8) is of cylindrical configuration, the outer diameter of the sleeve closure body (8) matching the inner diameter of the vascular clamp sleeve (5).
9. The vascular clamp for the rat model with ischemia reperfusion as claimed in any one of claims 1 to 8, wherein the vascular clamp sleeve (5) is a hollow tubular structure made of PP, PE or TPE.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922012837.9U CN211271342U (en) | 2019-11-20 | 2019-11-20 | Vascular clamp for ischemia reperfusion rat and mouse model |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922012837.9U CN211271342U (en) | 2019-11-20 | 2019-11-20 | Vascular clamp for ischemia reperfusion rat and mouse model |
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| Publication Number | Publication Date |
|---|---|
| CN211271342U true CN211271342U (en) | 2020-08-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922012837.9U Expired - Fee Related CN211271342U (en) | 2019-11-20 | 2019-11-20 | Vascular clamp for ischemia reperfusion rat and mouse model |
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| CN (1) | CN211271342U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112790814A (en) * | 2021-01-21 | 2021-05-14 | 吴一芃 | Rapid vascular blocking device for free flap transplantation operation and use method thereof |
| CN116492099A (en) * | 2023-06-16 | 2023-07-28 | 昆明市第一人民医院 | Method for establishing rat tree shrew xenogeneic in-situ liver transplantation model |
-
2019
- 2019-11-20 CN CN201922012837.9U patent/CN211271342U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112790814A (en) * | 2021-01-21 | 2021-05-14 | 吴一芃 | Rapid vascular blocking device for free flap transplantation operation and use method thereof |
| CN116492099A (en) * | 2023-06-16 | 2023-07-28 | 昆明市第一人民医院 | Method for establishing rat tree shrew xenogeneic in-situ liver transplantation model |
| CN116492099B (en) * | 2023-06-16 | 2023-09-15 | 昆明市第一人民医院 | Bile duct puncture outfit for rat tree shrew xenogeneic in-situ liver transplantation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Yan Lei Inventor after: Yu Jun Inventor after: Lei Shengping Inventor after: Chen Baoying Inventor after: Wang Pengli Inventor before: Yan Lei Inventor before: Yu Jun Inventor before: Lei Shengping Inventor before: Chen Baoying Inventor before: Wang Pengli |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200818 Termination date: 20211120 |