CN207886305U - Mouse abdominal cavity vein ligation auxiliary device with threading hole at tail part - Google Patents

Abstract

The utility model discloses a mouse celiac vein ligation assistant with a threading hole at the tail, aiming to solve the problem of damaging the mouse celiac artery and vein in the process of separating the mouse celiac artery and vein, resulting in blood vessel rupture and low success rate of ligation question. It includes a hand-held part, a first connecting part, a second connecting part and a tail part, and a threading hole is arranged at the end of the tail part. When performing mouse celiac vein ligation, pass the ligature thread through the threading hole, and use the tail to pass the ligature thread through the bottom of the celiac vein. The utility model is easy to operate, requires low technical proficiency of the operator, can greatly reduce the possibility of damage to the abdominal arteries and veins of mice, reduce the damage to the renal veins during threading, and improve the success rate of ligation and threading during experiments. It can effectively shorten operation time, reduce experimental wound, is easy to produce, and is beneficial to popularization and application.

Description

Mouse celiac vein ligation aid with a threading hole in the tail

technical field

The utility model relates to the field of surgical instruments for experimental animals, in particular to an auxiliary threading ligation tool for ligation of the abdominal cavity veins of mice.

Background technique

Venous thromboembolic disease is a complex vascular disease, clinically divided into deep vein thrombosis and pulmonary embolism. Venous thrombosis mainly occurs under the conditions of sluggish venous blood flow, blood hypercoagulability and vascular intima injury, and is one of the main factors of clinical death or disability. Experimental animals, especially mice, have become important model animals for the current research on the pathogenesis of venous thrombosis because of their low cost and ease of manipulation at the genetic level. Large vessel models in mice, such as mouse celiac vein ligation, can simulate the kinetics of venous thrombosis, histopathological characteristics of thrombus, and clinical features after thrombosis, and are currently one of the important models for studying venous thrombosis.

The diameter of the celiac vein in mice is about 2mm, and the abdominal surgical incision is less than 10mm during the ligation of the celiac vein. During the operation, the vision is extremely poor and the operation is difficult. The celiac vein and the artery of the mouse are connected with each other. During ligation, the celiac artery and vein are separated by surgical forceps at the bifurcation of the renal vein, and then the celiac vein is separated from the tissue at the bottom of the vein. Finally, the surgical thread is threaded through the bottom of the vein. Performed a ligation. Because the mouse celiac vein is extremely soft and fragile, during the operation, the separation of the celiac artery and vein, the separation of the vein and the surrounding tissue, and the process of using surgical forceps to pass the ligature through the bottom of the vein can easily damage the venous blood vessel, resulting in modeling fail. Notification number is that the patent literature of CN20479732U discloses a kind of venous vessel ligation device, but it can only be applied on human body. Because most of the human veins have a diameter of more than 10mm and are not connected to arteries, there is no need to worry about the surgical space and surgical field of view during surgery. The needle shaft of this ligator has no bending, and it is easy to rub and damage the surrounding tissue and the surgical incision during the operation. The operation needs to be large enough for the surgical opening and there is no interference from other tissues around it, but the mouse abdominal vein ligation does not meet such conditions. The needle part of this ligator has no hollows, and it is very easy for mice to block the line of sight and puncture blood vessels or other tissues during surgery. A miniature electric telescopic rod is installed between the needle handle and the needle rod of this ligator, resulting in a large diameter of the grip part of the device, which is not easy to perform micro-manipulation, and is not feasible in mouse surgery. Installing a miniature electric telescopic rod prevents the ligator from being sterilized by high temperature and high pressure, which may easily lead to surgical infection and increase the probability of modeling failure. In addition, the installation will sharply increase the cost of the ligator, which is not conducive to the popularization of the ligator. For the above problems, there is no better solution at present.

Contents of the invention

The purpose of the utility model is to solve the problem that when the mouse celiac artery and vein are separated, the vein and surrounding tissues and the ligature thread passing through the vein can easily damage the venous vessel and cause the failure of modeling, and provide a mouse celiac vein ligation assistant.

The scheme adopted by the utility model to solve the problems of the technologies described above is:

A mouse celiac vein ligation assistant, comprising a hand-held part, a first connecting part, a second connecting part and a tail, characterized in that: the hand-held part is connected to the first connecting part, the first connecting part is connected to the second connecting part, The second connecting part is connected with the tail; the tail is in the shape of a hook and the end is provided with a threading hole. The handle can be cylindrical for gripping. Both the first connecting part and the second connecting part are cylindrical. The hook-shaped tail is convenient for puncturing from the bottom of the vein, the ligature can pass through the threading hole, and the ligature moves with the tail during puncture.

Further, the first connection part and the second connection part form an included angle of 130-160 degrees. Thereby avoiding the frictional damage of the first connecting part to the renal vein during the operation, and at the same time avoiding the hindering effect of the renal vein on the mouse celiac vein ligation aid. Preferably, the first connection part and the second connection part form an included angle of 145 degrees.

Furthermore, the middle of the tail is hollowed out. It is convenient to observe the tissue under the tail from the hollow when the puncture is blocked.

Further, the handle part, the first connection part, the second connection part and the tail part are all made of medical stainless steel. Medical stainless steel is not only suitable for surgery, but also has high hardness, which can better support the force of tail puncture.

The beneficial effects of the utility model are: it can effectively avoid damage to abdominal arteries, veins and renal veins, shorten operation time, reduce operation wounds, and increase the success rate of modeling. Moreover, the operation is convenient and easy, and it is easy to be sterilized by high-pressure steam.

Description of drawings

Fig. 1 is the structural representation of the utility model.

FIG. 2 is a partially enlarged view of FIG. 1 .

Fig. 3 is a schematic front view of the utility model.

Fig. 4 is a schematic side view of the utility model.

Figure 5 is a schematic diagram of the distribution of celiac arteries and veins in mice.

In the figure, 1. Hand-held part, 2. First connecting part, 3. Second connecting part, 4. Tail part, 401, threading hole, 402, hollow structure, 5. Renal vein, 6. Celiac vein, 7. Ligation site (site of separation of celiac artery and vein), 8, celiac artery.

Detailed ways

Example 1

As shown in FIGS. 1-4 , a mouse celiac vein ligation assistant includes a hand-held part 1 , a first connecting part 2 , a second connecting part 3 and a tail part 4 . The handle part 1 is in the shape of a cylinder, the first connecting part 2 and the second connecting part 3 are in the shape of a cylinder slightly smaller than the handle part 1 , and the tail part 4 is in the shape of a hook and has a circular threading hole 401 . One end of the handle part 1 is fixedly connected to one end of the first connecting part 2 , the other end of the first connecting part 2 is fixedly connected to one end of the second connecting part 3 , and the other end of the second connecting part 3 is fixedly connected to the tail part 4 . The handle part 1, the first connecting part 2, the second connecting part 3 and the tail part 4 are all made of medical stainless steel.

As shown in FIG. 2 , there is a hollow structure 402 in the middle of the tail part 4 .

As shown in Figure 3 and Figure 4, the angle between the first connecting part 2 and the second connecting part 3 is 145 degrees; the length of the handle part 1 is 60 mm, and the diameter is 5 mm; the length of the first connecting part 2 is 25 mm ; Tail 4 is 5 mm long, 5 mm wide, and 3 mm high.

As shown in FIG. 5 , when performing mouse celiac vein ligation, the ligature thread was passed through the threading hole 401 of the tail 4, and after the celiac vein was separated from the artery and surrounding tissues, the tail 4 was slowly punctured from the bottom of the vein. The second connecting part 3 is beneficial to avoid the interference of the branches of the renal vein during operation, and at the same time avoid damage to the renal vein. After delivering the ligature from one side of the vein to the other, part of the ligature is withdrawn, cut in the middle, and the tail 4 is retracted the same way. Or, at first directly the tail 4 is slowly punctured from the bottom of the vein, after the other side of the vein exposes the threading hole 402, the ligature is passed through the threading hole 402; One side of the vein is brought to the other side and further ligation is done. In this way, the operation time can be effectively shortened, the operation wound can be reduced, the success rate of modeling can be improved, and the operation is convenient and easy.

Example 2

In Embodiment 1, the included angle between the first connecting part 2 and the second connecting part 3 is changed to 130 degrees, and the others remain unchanged.

Example 3

In Embodiment 1, the included angle between the first connecting part 2 and the second connecting part 3 is changed to 160 degrees, and the others remain unchanged.

The above descriptions are only preferred embodiments of the present utility model, and are not intended to limit the present utility model. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present utility model shall be included in this utility model. within the scope of protection of utility models.

Claims (3)

1. A mouse celiac vein ligation aid, comprising a hand-held part, a first connecting part, a second connecting part and a tail, characterized in that: the hand-held part is connected with the first connecting part, and the first connecting part is connected with the second connecting part Connection, the second connecting part is connected to the tail, the first connecting part and the second connecting part form an angle of 130~160 degrees; the tail is hook-shaped and the end is provided with a threading hole, and the middle of the tail is hollowed out. 2 . The mouse abdominal vein ligation assistant according to claim 1 , wherein the angle between the first connecting part and the second connecting part is 145 degrees. 3. The mouse celiac vein ligation aid as claimed in claim 1 or 2, characterized in that: the hand-held part, the first connecting part, the second connecting part and the tail are all made of medical stainless steel.