CN211216680U - One-pot synthesis equipment for anticancer drug 6-hydroxyl selenious acid esterified chitosan copper - Google Patents
One-pot synthesis equipment for anticancer drug 6-hydroxyl selenious acid esterified chitosan copper Download PDFInfo
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- CN211216680U CN211216680U CN201922033769.4U CN201922033769U CN211216680U CN 211216680 U CN211216680 U CN 211216680U CN 201922033769 U CN201922033769 U CN 201922033769U CN 211216680 U CN211216680 U CN 211216680U
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- motor
- reaction furnace
- mixing reaction
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- 239000002246 antineoplastic agent Substances 0.000 title claims abstract description 22
- 229940041181 antineoplastic drug Drugs 0.000 title claims abstract description 22
- 238000005580 one pot reaction Methods 0.000 title claims abstract description 15
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 229910052802 copper Inorganic materials 0.000 title claims abstract description 11
- 239000010949 copper Substances 0.000 title claims abstract description 11
- -1 6-hydroxyl selenious acid Chemical compound 0.000 title abstract description 9
- 229940000207 selenious acid Drugs 0.000 title abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 34
- 238000002156 mixing Methods 0.000 claims abstract description 30
- 238000006243 chemical reaction Methods 0.000 claims abstract description 27
- 238000013329 compounding Methods 0.000 claims abstract description 23
- 238000001816 cooling Methods 0.000 claims abstract description 18
- 239000007787 solid Substances 0.000 claims abstract description 14
- 238000003756 stirring Methods 0.000 claims description 14
- 230000007246 mechanism Effects 0.000 claims description 12
- 238000005485 electric heating Methods 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 2
- 238000011068 loading method Methods 0.000 abstract description 47
- 239000003814 drug Substances 0.000 abstract description 33
- 239000002994 raw material Substances 0.000 abstract description 27
- 239000011343 solid material Substances 0.000 abstract description 20
- 229940079593 drug Drugs 0.000 abstract description 7
- 229940126589 solid medicine Drugs 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 5
- 238000010438 heat treatment Methods 0.000 abstract description 5
- 238000000926 separation method Methods 0.000 abstract description 5
- 230000032050 esterification Effects 0.000 abstract description 4
- 238000005886 esterification reaction Methods 0.000 abstract description 4
- 239000000843 powder Substances 0.000 abstract description 4
- 238000005119 centrifugation Methods 0.000 abstract description 3
- 239000013078 crystal Substances 0.000 abstract 1
- 239000011344 liquid material Substances 0.000 description 14
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000003786 synthesis reaction Methods 0.000 description 5
- 230000006872 improvement Effects 0.000 description 4
- 229940082569 selenite Drugs 0.000 description 4
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model provides a one-pot synthesis device of anticancer drug 6-hydroxyl selenious acid esterification chitosan copper, which comprises a material mixing reaction furnace and a centrifugal barrel, wherein different drug raw materials are mixed and heated through the material mixing reaction furnace, the drug raw materials after the mixed reaction are filtered and separated through the centrifugal barrel, and the separated liquid medicine is cooled through a cooling box to separate out crystals; compounding reacting furnace, the cooperation setting of centrifugation bucket and cooler bin, make this anticancer drugs synthesizer possess the heating compounding simultaneously, the function that filtering separation and cooling were appeared, thereby make this equipment function abundant diversified, the setting of workbin on liquid and the solid, make this equipment can carry out the material loading to liquid medicine raw materials and solid medicine raw materials simultaneously, the material loading efficiency has been promoted, flow control valve's setting, make this equipment material loading ratio more accurate, the setting of the spiral (mixing) shaft on the solid material loading case, it is more even to make this equipment carry out powdered solid material loading, the problem of powder caking jam has also been avoided.
Description
Technical Field
The utility model relates to the technical field of medicine production equipment, in particular to one-pot synthesis equipment for an anticancer medicine, namely 6-hydroxyl selenious acid esterified chitosan copper.
Background
In the treatment of cancer, drug therapy is an important link, effective anticancer drugs are used, a patient can be helped to obtain longer survival time, and the hope of survival is met, the most common anticancer drugs at present comprise chemotherapy drugs, traditional Chinese medicines, biopharmaceuticals, targeted drugs and the like, in the drug production process, mechanical equipment is often used for mixing drug raw materials, so that the effect of full mixing can be achieved, and synthesis equipment of the anticancer drugs is needed;
in the prior art, the synthesis equipment of anticancer drugs generally only has one function, such as heating, cooling and separation, and during the loading, only one drug raw material can be added at a time, so that the loading efficiency is low, the loading amount is not convenient to control, and the drug synthesis proportion is not accurate enough, therefore, the utility model provides a one-pot synthesis equipment of anticancer drug 6-hydroxyl selenite esterified chitosan copper so as to solve the problems in the prior art.
SUMMERY OF THE UTILITY MODEL
The utility model provides a one-pot synthesis equipment of anticancer drug 6-hydroxyl selenious acid esterification chitosan copper, which is used for solving the problems of single function, low feeding efficiency and inaccurate synthesis proportion of the prior anticancer drug synthesis equipment in the technical background.
In order to achieve the purpose, the utility model provides a one-pot synthesis device of anticancer drug 6-hydroxyl selenite esterified chitosan copper, which comprises a material mixing reaction furnace and a centrifugal barrel, wherein the material mixing reaction furnace is fixed on a base through a support frame, the inner side wall of the material mixing reaction furnace is provided with an electric heating coil pipe, the bottom of the material mixing reaction furnace is provided with a material discharging pipe, and the material discharging pipe is provided with a first butterfly valve;
the centrifugal barrel is fixed on the base through a support column, the rotary drum inside the centrifugal barrel is connected to the output end of the first motor through a first rotating shaft, a liquid discharge pipe is installed on the side wall of the centrifugal barrel, a second butterfly valve is installed on the liquid discharge pipe, filter holes are formed in the side wall of the rotary drum, and a drainage plate and a guide plate are fixed on the side wall of the rotary drum and the side wall of the centrifugal barrel respectively.
The further improvement lies in that: be equipped with rabbling mechanism on the compounding reacting furnace, rabbling mechanism includes motor case and second motor, the second motor is installed in the inside of motor case, the output of second motor passes the retarder connection and has the second pivot, the one end that the second motor was kept away from in the second pivot runs through the inside of compounding reacting furnace and installs the stirring leaf through the bearing.
The further improvement lies in that: be equipped with feed mechanism on the compounding reacting furnace, feed mechanism is including the liquid material loading case and the solid material loading case that the symmetry set up, the top of liquid material loading case is equipped with liquid feed inlet, one side that liquid material loading case is close to the motor case is installed and is extended to the inside liquid material loading pipe of compounding reacting furnace, install flow control valve on the liquid material loading pipe, the top of solid material loading case is equipped with solid feed inlet, the solid material loading pipe that extends to compounding reacting furnace inside is installed to the bottom of solid material loading case, the intraductal spiral stirring shaft that is equipped with of solid material loading, the one end that the motor case was kept away from to spiral stirring shaft runs through solid material loading union coupling in miniature rotating electrical machines through the bearing.
The further improvement lies in that: one side of the liquid discharge pipe far away from the centrifugal barrel extends to the inside of the cooling box, a refrigerator is installed at the top end of the inside of the cooling box, a finished product collecting drawer is installed at the bottom end of the inside of the cooling box in a sliding mode, and a handle is fixed to one side, far away from the liquid discharge pipe, of the finished product collecting drawer.
The further improvement lies in that: a first temperature sensor is installed on the top end of the mixing reaction furnace, and a second temperature sensor is installed on the top end of the cooling box.
The utility model has the advantages that: this one-pot method former of anticancer drugs 6-hydroxyl selenite esterification chitosan copper includes compounding reacting furnace and centrifugation bucket, through the compounding reacting furnace, the cooperation setting of centrifugation bucket and cooler bin, make this anticancer drugs former possess the heating compounding simultaneously, the function that filtering separation and cooling were appeared, thereby make this equipment function richen diversification, setting through liquid material loading case and solid material loading case, make this equipment can carry out the material loading to liquid medicine raw materials and solid medicine raw materials simultaneously, material loading efficiency has been promoted, setting through the flow control valve on the liquid material loading case, make this equipment material loading proportion more accurate, setting through the spiral stirring shaft on the solid material loading case, it is more even to make this equipment carry out powdered solid material loading, the problem of powder caking jam has also been avoided.
Drawings
Fig. 1 is a front view of the present invention.
Fig. 2 is a sectional view of the present invention.
Wherein: 1. a material mixing reaction furnace; 2. a centrifuge bucket; 3. a support frame; 4. a base; 5. an electric heating coil pipe; 6. a discharge pipe; 7. a first butterfly valve; 8. a support pillar; 9. a drum; 10. a first rotating shaft; 11. a first motor; 12. a liquid discharge pipe; 13. a second butterfly valve; 14. filtering holes; 15. a drainage plate; 16. a baffle; 17. a motor case; 18. a second motor; 19. a speed reducer; 20. a second rotating shaft; 21. stirring blades; 22. a liquid feeding box; 23. a solid feeding box; 24. a liquid feed port; 25. a liquid feeding pipe; 26. a flow control valve; 27. a solids feed port; 28. a solids feed pipe; 29. a spiral stirring shaft; 30. a miniature rotating electrical machine; 31. a cooling tank; 32. a refrigerator; 33. a finished product collection drawer; 34. a handle; 35. a first temperature sensor; 36. a second temperature sensor.
Detailed Description
In order to deepen the understanding of the present invention, the following embodiments will be combined to make the present invention do further details, and the present embodiment is only used for explaining the present invention, and does not constitute the limitation of the protection scope of the present invention.
According to the drawings 1 and 2, the embodiment provides a one-pot synthesis device of an anticancer drug, namely 6-hydroxyselenite esterified chitosan copper, which comprises a mixing reaction furnace 1 and a centrifugal barrel 2, wherein the mixing reaction furnace 1 is fixed on a base 4 through a support frame 3, an electric heating coil 5 is arranged on the inner side wall of the mixing reaction furnace 1 and used for heating drug raw materials, a material discharge pipe 6 is arranged at the bottom of the mixing reaction furnace 1, and a first butterfly valve 7 is arranged on the material discharge pipe 6 and used for controlling the material discharge pipe 6 to be opened and closed;
In this embodiment, be equipped with rabbling mechanism on compounding reacting furnace 1 for mix the pharmaceutical raw materials, rabbling mechanism includes motor case 17 and second motor 18, second motor 18 is installed in the inside of motor case 17, reduction gear 19 is passed to the output of second motor 18 and is connected with second pivot 20, second pivot 20 is kept away from the one end of second motor 18 and is run through to the inside of compounding reacting furnace 1 through the bearing and install stirring leaf 21 for mix the different pharmaceutical raw materials of stirring.
In this embodiment, be equipped with feed mechanism on compounding reation furnace 1 for add compounding reation furnace 1 with the medicine raw materials, feed mechanism is including liquid material loading case 22 and the solid material loading case 23 that the symmetry set up, liquid material loading case 22's top is equipped with liquid feed inlet 24, liquid material loading case 22 is close to one side of motor case 17 and installs the liquid material loading pipe 25 that extends to compounding reation furnace 1 inside, install flow control valve 26 on the liquid material loading pipe 25 for control liquid medicine raw materials material loading volume, the top of solid material loading case 23 is equipped with solid feed inlet 27, the solid material loading pipe 28 that extends to compounding reation furnace 1 inside is installed to the bottom of solid material loading case 23, the intraductal spiral (mixing) shaft 29 that is equipped with of solid material loading for break up powdered solid medicine raw materials, prevent the powder caking and block up, the one end that motor case 17 was kept away from to spiral (mixing) shaft 29 runs through solid material loading pipe 28 through the bearing and connects in miniature And a machine 30.
In this embodiment, one side that fluid-discharge tube 12 kept away from centrifugal barrel 2 extends to the inside of cooling tank 31, refrigerator 32 is installed on the inside top of cooling tank 31 for the liquid medicine of cooling separation to it obtains the finished product medicine to separate out the crystallization, the inside bottom slidable mounting of cooling tank 31 has finished product collection steamer tray 33, is used for collecting the finished product medicine, one side that fluid-discharge tube 12 was kept away from to finished product collection steamer tray 33 is fixed with handle 34.
In this embodiment, first temperature-sensing ware 35 is installed on compounding reacting furnace 1 top for observe the temperature in compounding reacting furnace 1, second temperature-sensing ware 36 is installed on the top of cooling box 31 for observe the temperature in the cooling box 31.
Firstly, respectively adding liquid medicine raw materials and solid medicine raw materials into a liquid feeding box 22 and a solid feeding box 23, then controlling quantitative liquid medicine raw materials to enter a material mixing reaction furnace 1 through a flow control valve 26, starting a micro rotating motor 30 to uniformly flow the solid medicine raw materials into the material mixing reaction furnace 1 through a spiral stirring shaft 29 according to the proportion of the liquid medicine raw materials, then starting a second motor 18 and an electric heating coil pipe 5 to heat and stir different types of medicine raw materials, starting a first motor 11 to drive a rotary drum 9 before the medicine raw materials react in the material mixing reaction furnace 1, starting a first butterfly valve 7 after the medicine raw materials react in the material mixing reaction furnace 1, flowing the medicine raw materials subjected to mixed reaction into a centrifugal barrel 2, starting a second butterfly valve 13 when the medicine raw materials are filtered and separated out medicine liquid through the rotary drum 9, and flowing the medicine liquid into a cooling box 31 through a liquid discharge pipe 12, and finally, the refrigerator 32 is started to cool the liquid medicine, and after the liquid medicine is cooled, separated out and crystallized, the finished product collection drawer 33 is taken out to finish the collection of the finished product of the medicine.
This one-pot method former of anticancer drugs 6-hydroxyl selenite esterification chitosan copper includes compounding reacting furnace 1 and centrifuge bucket 2, through compounding reacting furnace 1, centrifuge bucket 2 and cooler bin 31's cooperation sets up, make this anticancer drugs former possess the heating compounding simultaneously, the function that filtering separation and cooling were appeared, thereby make this equipment function richen diversified, setting through liquid material loading case 22 and solid material loading case 23, make this equipment can carry out the material loading to liquid medicine raw materials and solid medicine raw materials simultaneously, material loading efficiency has been promoted, setting through flow control valve 26 on the liquid material loading case 22, make this equipment material loading proportion more accurate, setting through spiral stirring shaft 29 on the solid material loading case 23, it is more even to make this equipment carry out powdered solid material loading, the problem of powder raw materials caking jam has also been avoided.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the above embodiments, and that the foregoing embodiments and descriptions are provided only to illustrate the principles of the present invention without departing from the spirit and scope of the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (5)
1. The one-pot synthesis equipment for the anticancer drug of the chitosan copper 6-hydroxyselenite is characterized in that: the material mixing reaction furnace comprises a material mixing reaction furnace (1) and a centrifugal barrel (2), wherein the material mixing reaction furnace (1) is fixed on a base (4) through a support frame (3), an electric heating coil (5) is arranged on the inner side wall of the material mixing reaction furnace (1), a material discharging pipe (6) is installed at the bottom of the material mixing reaction furnace (1), and a first butterfly valve (7) is installed on the material discharging pipe (6);
the centrifugal barrel (2) is fixed on the base (4) through a support column (8), a rotary drum (9) inside the centrifugal barrel (2) is connected to the output end of a first motor (11) through a first rotating shaft (10), a liquid discharge pipe (12) is installed on the side wall of the centrifugal barrel (2), a second butterfly valve (13) is installed on the liquid discharge pipe (12), a filter hole (14) is formed in the side wall of the rotary drum (9), and a drainage plate (15) and a guide plate (16) are fixed on the side walls of the rotary drum (9) and the centrifugal barrel (2) respectively.
2. The one-pot synthesis apparatus of anticancer drug, chitosan-6-hydroxyselenite esterified according to claim 1, characterized in that: be equipped with rabbling mechanism on compounding reacting furnace (1), rabbling mechanism includes motor case (17) and second motor (18), install in the inside of motor case (17) second motor (18), the output of second motor (18) passes reduction gear (19) and is connected with second pivot (20), the one end that second motor (18) were kept away from in second pivot (20) runs through the inside of compounding reacting furnace (1) and installs stirring leaf (21) through the bearing.
3. The one-pot synthesis apparatus of anticancer drug, chitosan-6-hydroxyselenite esterified according to claim 1, characterized in that: the material mixing reaction furnace (1) is provided with a feeding mechanism, the feeding mechanism comprises a liquid feeding box (22) and a solid feeding box (23) which are symmetrically arranged, a liquid feeding hole (24) is formed in the top end of the liquid feeding box (22), a liquid feeding pipe (25) extending into the mixing reaction furnace (1) is installed on one side, close to the motor box (17), of the liquid feeding box (22), a flow control valve (26) is arranged on the liquid feeding pipe (25), a solid feeding hole (27) is arranged at the top end of the solid feeding box (23), a solid feeding pipe (28) extending to the interior of the mixing reaction furnace (1) is arranged at the bottom of the solid feeding box (23), the solid feeding pipe (28) is internally provided with a spiral stirring shaft (29), and one end of the spiral stirring shaft (29), which is far away from the motor box (17), penetrates through the solid feeding pipe (28) through a bearing and is connected with a micro rotating motor (30).
4. The one-pot synthesis apparatus of anticancer drug, chitosan-6-hydroxyselenite esterified according to claim 1, characterized in that: one side that fluid-discharge tube (12) kept away from centrifugal barrel (2) extends to the inside of cooler bin (31), refrigerator (32) are installed on the inside top of cooler bin (31), the inside bottom slidable mounting of cooler bin (31) has finished product collection drawer (33), one side that fluid-discharge tube (12) was kept away from in finished product collection drawer (33) is fixed with handle (34).
5. The one-pot synthesis apparatus of anticancer drug, chitosan-6-hydroxyselenite esterified according to claim 4, characterized in that: a first temperature sensor (35) is installed on the top end of the mixing reaction furnace (1), and a second temperature sensor (36) is installed on the top end of the cooling box (31).
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CN201922033769.4U CN211216680U (en) | 2019-11-22 | 2019-11-22 | One-pot synthesis equipment for anticancer drug 6-hydroxyl selenious acid esterified chitosan copper |
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CN201922033769.4U CN211216680U (en) | 2019-11-22 | 2019-11-22 | One-pot synthesis equipment for anticancer drug 6-hydroxyl selenious acid esterified chitosan copper |
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CN201922033769.4U Expired - Fee Related CN211216680U (en) | 2019-11-22 | 2019-11-22 | One-pot synthesis equipment for anticancer drug 6-hydroxyl selenious acid esterified chitosan copper |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN112156493A (en) * | 2020-09-21 | 2021-01-01 | 山东民基新材料科技有限公司 | Crystallization centrifuge |
CN112479927A (en) * | 2020-11-03 | 2021-03-12 | 浙江汇翔新材料科技股份有限公司 | Production process of N-cyanoethyl-N-benzylaniline |
CN112791681A (en) * | 2020-12-28 | 2021-05-14 | 新昌县辰逸服饰有限公司 | Preparation facilities of prevent wind dacron fabric coating agent |
CN113758193A (en) * | 2021-09-22 | 2021-12-07 | 南京一苇医药科技有限公司 | Device is air-dried in crystal washing for intermediate preparation of medicine |
CN115155485A (en) * | 2021-05-28 | 2022-10-11 | 王孟阳 | Synthesis and screening equipment for anti-cancer stem cell drug molecules and operation method thereof |
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2019
- 2019-11-22 CN CN201922033769.4U patent/CN211216680U/en not_active Expired - Fee Related
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112156493A (en) * | 2020-09-21 | 2021-01-01 | 山东民基新材料科技有限公司 | Crystallization centrifuge |
CN112479927A (en) * | 2020-11-03 | 2021-03-12 | 浙江汇翔新材料科技股份有限公司 | Production process of N-cyanoethyl-N-benzylaniline |
CN112479927B (en) * | 2020-11-03 | 2022-06-14 | 浙江汇翔新材料科技股份有限公司 | Production process of N-cyanoethyl-N-benzylaniline |
CN112791681A (en) * | 2020-12-28 | 2021-05-14 | 新昌县辰逸服饰有限公司 | Preparation facilities of prevent wind dacron fabric coating agent |
CN115155485A (en) * | 2021-05-28 | 2022-10-11 | 王孟阳 | Synthesis and screening equipment for anti-cancer stem cell drug molecules and operation method thereof |
CN113758193A (en) * | 2021-09-22 | 2021-12-07 | 南京一苇医药科技有限公司 | Device is air-dried in crystal washing for intermediate preparation of medicine |
CN113758193B (en) * | 2021-09-22 | 2022-12-06 | 南京一苇医药科技有限公司 | Device is air-dried in crystal washing for intermediate preparation of medicine |
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Granted publication date: 20200811 |