CN115155485A - Synthesis and screening equipment for anti-cancer stem cell drug molecules and operation method thereof - Google Patents
Synthesis and screening equipment for anti-cancer stem cell drug molecules and operation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of drug production, and discloses synthesis and screening equipment of anticancer stem cell drug molecules and an operation method thereof, wherein the synthesis and screening equipment comprises a bottom plate, the top of the bottom plate is bolted with a frame body, the top of the frame body is bolted with a mixing barrel, the top of the mixing barrel is bolted with a first motor, the output end of the first motor is bolted with a rotating rod, and the two sides of the rotating rod are both bolted with stirring pieces; according to the invention, the anti-cancer liquid medicine in the liquid medicine barrel and the anti-cancer medicine powder in the solid medicine barrel are controlled by the conveying mechanism through the flow control valve, so that powder agglomeration and blockage are prevented, medicine proportioning is accurately controlled, and quantitative proportioning effect is improved; according to the invention, the rotating rod is driven to rotate by the first motor, so that the stirring blade is used for stirring the interior of the mixing barrel, and the heating pipe is used for heating, mixing and stirring the anticancer liquid medicine and the anticancer powder more fully, and the medicine body mixing effect is improved.
Description
Technical Field
The invention relates to the technical field of drug production, in particular to a device for synthesizing and screening anti-cancer stem cell drug molecules and an operation method thereof.
Background
Anticancer drugs are classified into western drugs and Chinese drugs according to their therapeutic characteristics. The western medicines comprise chemotherapy and biological target treatment medicines, and the traditional Chinese medicines comprise clinically common prescription medicines and Chinese patent medicines. The change of living environment and mode, the aging of population, the increase of survival pressure and other objective factors cause the increasing of incidence of malignant tumor in China, become the first lethal disease, in the treatment of cancer, drug therapy is an important link, the use of effective anticancer drugs can help patients to obtain longer survival time, and have the hope of surviving, the most common anticancer drugs at present are chemotherapy drugs, traditional Chinese medicines, biopharmaceuticals, targeting drugs and the like, in the drug production process, mechanical equipment can be frequently used for mixing drug raw materials to achieve the effect of full mixing, so that synthesis equipment of the anticancer drugs is needed, the traditional equipment cannot mix, stir and heat the drugs uniformly, powder agglomeration and blockage are easy to generate, the drug ratio cannot be accurately controlled, and the drugs cannot be cooled and separated out during separation and screening, and the synthesis and screening equipment of anticancer dry cell drug molecules and the operation method thereof are provided for solving the problems.
Disclosure of Invention
The invention aims to provide equipment for synthesizing and screening anticancer stem cell drug molecules and an operation method thereof, which have the advantages of fully mixing, preventing powder from caking and quantitatively controlling the drug ratio and solve the problems that the traditional equipment cannot mix, stir and heat the drug molecules, is not uniform in stirring, is easy to cause powder caking and blockage, cannot accurately control the drug ratio and cannot be cooled and separated out during separation and screening.
In order to achieve the purpose, the invention provides the following technical scheme: the synthesis and screening device for the anticancer stem cell drug molecules comprises a base plate, wherein a frame body is bolted to the top of the base plate, a mixing barrel is bolted to the top of the frame body, a first motor is bolted to the top of the mixing barrel, a rotating rod is bolted to the output end of the first motor, stirring sheets are bolted to two sides of the rotating rod, a liquid medicine barrel is bolted to the left side of the top of the mixing barrel, a pipe body is communicated with the top of the mixing barrel on the right side of the liquid medicine barrel, a solid medicine barrel is installed on the right side of the top of the mixing barrel, a conveying mechanism is communicated between the bottom of the solid medicine barrel and the top of the mixing barrel, a discharge pipe is communicated with the bottom of the mixing barrel, a box body is communicated with the lower end of the discharge pipe, a first drawer is slidably connected to the front of the box body, an air cylinder is bolted to the left side of the inner wall of the box body, a filter sieve is bolted to the right end of the air cylinder, a clamping support spring is connected between the right side of the filter sieve and the right side of the inner wall of the box body, a material pipe is communicated with a medicine box body, and a second drawer is slidably connected to the right side of the medicine box.
Preferably, the conveying mechanism comprises a conveying frame, a second motor is bolted to the right side of the conveying frame, and an output end of the second motor penetrates through the right side of the conveying frame and is bolted to a spiral stirring shaft.
Preferably, the top of liquid medicine bucket and solid medicine bucket all communicates there is the feeder hopper, and the top joint of feeder hopper has the shield.
Preferably, the surface of the stirring sheet is provided with a slotted hole, the top of the inner wall of the mixing barrel is bolted with a heating pipe, and the top of the inner wall of the medicine box is bolted with a refrigerating pipe.
Preferably, a flow control valve is installed at the top of the pipe body, and a butterfly valve is installed at the top of the discharge pipe.
The operation method of the equipment for synthesizing and screening the anti-cancer stem cell drug molecules comprises the following steps:
step 1: respectively adding liquid medicine raw materials and solid medicine raw materials into a liquid medicine barrel and a solid medicine barrel;
step 2: quantitative liquid medicine raw materials enter the mixing barrel through a flow control valve, and the liquid medicine raw materials are mixed according to the proportion;
and step 3: starting a second motor to feed the solid medicine raw materials into the mixing barrel;
and 4, step 4: starting a first motor and a heating pipe to heat and stir different kinds of medicine raw materials;
and 5: opening a butterfly valve after the medicine raw materials react in the mixing barrel, and enabling the medicine raw materials subjected to the mixing reaction to flow into the top of the filter sieve in the box body;
and 6: starting the cylinder, pushing the filter screen to extrude the support spring to horizontally vibrate, enabling the liquid medicine to flow into the medicine box through the material pipe, flow into the second drawer, and flow into the first drawer through the part which does not pass through the material pipe;
and 7: opening the refrigerating pipe to cool the liquid medicine;
and 8: after the liquid medicine is cooled and crystallized, taking out the finished product of the medicine in the second drawer
Preferably, in step 3, the solid raw material enters the mixing barrel and is brought in by the rotation of the spiral stirring shaft, so as to break up the powdery solid medicine raw material, and avoid blocking caused by powder agglomeration, so that the solid medicine raw material cannot flow out quantitatively, and the synthesis of the anticancer medicine is affected.
Preferably, in step 4, the heating pipe is heated, so that the anticancer drug synthesis device is provided with a heating mixed material at the same time, the mixture is stirred and mixed more fully, the stirring is performed so as to enable the solute to be dissolved in the solvent more quickly, and the heating can enable the mixed anticancer drug to be heated uniformly.
Preferably, in step 5, the filter sieve is a molecular sieve, the molecular sieve is a crystalline silicate or aluminosilicate formed by connecting silicon-oxygen tetrahedrons or aluminum-oxygen tetrahedrons through oxygen bridges, the molecular sieve is an aluminosilicate compound with a cubic lattice, mainly a silicon-aluminum is connected through oxygen bridges to form an open framework structure, a plurality of pores with uniform pore diameters and cavities with large internal surface area are arranged in the framework, water molecules are continuously lost after heating, but the crystal framework structure is unchanged, a plurality of cavities with the same size are formed, the cavities are connected by a plurality of micropores with the same diameter, the diameters of the micropores are uniform, molecules with smaller diameters than those of the pores can be adsorbed into the interiors of the pores, molecules with larger diameters than those of the pores can be excluded, and molecules with different shapes, diameters, different molecules with different polarities, molecules with different boiling points and molecules with different saturation degrees can be separated.
Preferably, in step 7, the cooling tube is used for cooling the separated drug solution, the content of dissolved substances in the drug solution is high, and the excess dissolved substances are precipitated from the solution in the form of solid crystals through temperature reduction and solubility reduction, so that the finished drug is obtained through precipitation and crystallization.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, the anti-cancer liquid medicine in the liquid medicine barrel and the anti-cancer medicine powder in the solid medicine barrel are controlled by the conveying mechanism through the flow control valve, so that powder agglomeration and blockage are prevented, medicine proportioning is accurately controlled, and quantitative proportioning effect is improved;
according to the invention, the rotating rod is driven to rotate by the first motor, so that the stirring blade is used for stirring the interior of the mixing barrel, and the heating pipe is used for heating, mixing and stirring the anticancer liquid medicine and the anticancer powder more fully, and the medicine body mixing effect is improved.
Drawings
FIG. 1 is a front cross-sectional view of the structure of the present invention;
FIG. 2 is an enlarged view of a portion A of FIG. 1 according to the present invention.
In the figure: 1. a base plate; 2. a frame body; 3. a mixing barrel; 4. a first motor; 5. rotating the rod; 6. a stirring sheet; 7. a liquid medicine barrel; 8. a pipe body; 9. a medicine fixing barrel; 10. a conveying mechanism; 101. a conveying frame; 102. a second motor; 103. a spiral stirring shaft; 11. a discharge pipe; 12. a box body; 13. a first drawer; 14. a cylinder; 15. filtering and screening; 16. a support spring; 17. a material pipe; 18. a kit; 19. a second drawer; 20. a feed hopper; 21. a dust cover; 22. a slot; 23. heating a tube; 24. a refrigeration pipe; 25. a flow control valve; 26. butterfly valves.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-2, the present invention provides a technical solution: the synthesis and screening device of the anticancer stem cell drug molecules comprises a bottom plate 1, a frame body 2 is bolted at the top of the bottom plate 1, a mixing barrel 3 is bolted at the top of the frame body 2, a first motor 4 is bolted at the top of the mixing barrel 3, a rotating rod 5 is bolted at the output end of the first motor 4, stirring blades 6 are bolted at two sides of the rotating rod 5, a liquid drug barrel 7 is bolted at the left side of the top of the mixing barrel 3, a tube body 8 is communicated between the right side of the liquid drug barrel 7 and the top of the mixing barrel 3, a solid drug barrel 9 is installed at the right side of the top of the mixing barrel 3, a conveying mechanism 10 is communicated between the bottom of the solid drug barrel 9 and the top of the mixing barrel 3, a discharge tube 11 is communicated at the bottom of the mixing barrel 3, the lower end of the discharge pipe 11 is communicated with a box body 12, the front side of the box body 12 is connected with a first drawer 13 in a sliding mode, the left side of the inner wall of the box body 12 is connected with an air cylinder 14 in a bolting mode, the right end of the air cylinder 14 is connected with a filter sieve 15 in a bolting mode, a supporting spring 16 is clamped between the right side of the filter sieve 15 and the right side of the inner wall of the box body 12 in a clamping mode, the right side of the box body 12 is connected with a material pipe 17 in a communicating mode, the right end of the material pipe 17 is communicated with a medicine box 18, the right side of the medicine box 18 is connected with a second drawer 19 in a sliding mode, the anti-cancer medicine liquid in the liquid medicine barrel 7 and the anti-cancer medicine powder in the medicine fixing barrel 9 are controlled through a flow control valve 25, accordingly, blocking of powder is prevented, medicine proportioning is controlled accurately, and quantitative proportioning effect is improved; drive rotary rod 5 through first motor 4 and rotate, make stirring piece 6 stir in to mixing drum 3, the heat treatment of heating pipe 23 to it mixes more abundant to add the hot mixing stirring to resist cancer liquid medicine and anticancer powder, has improved the medicine body and has mixed the effect.
Further, conveying mechanism 10 includes transport frame 101, and the right side of transport frame 101 is bolted with second motor 102, and the output that second motor 102 runs through the right side of transport frame 101 and is bolted with spiral stirring shaft 103, through setting up conveying mechanism 10, plays the effect that prevents solid medicine caking and arouse the jam.
Further, the top of liquid medicine bucket 7 and solid medicine bucket 9 all communicates there is feeder hopper 20, and the top joint of feeder hopper 20 has shield 21, through setting up shield 21, plays the effect that prevents debris such as dust and get into.
Furthermore, slotted holes 22 are formed in the surface of the stirring sheet 6, a heating pipe 23 is bolted to the top of the inner wall of the mixing barrel 3, a refrigerating pipe 24 is bolted to the top of the inner wall of the medicine box 18, the heating pipe 23 is arranged, the medicine after mixing is heated uniformly, and the refrigerating pipe 24 achieves the purpose of condensing and crystallizing.
Further, flow control valve 25 is installed at the top of body 8, and butterfly valve 26 is installed at the top of discharging pipe 11, through setting up flow control valve 25, plays the purpose of quantitative control liquid medicine volume, is convenient for accurately dispense.
The operation method of the synthesis and screening equipment of the anti-cancer stem cell drug molecule comprises the following steps:
step 1: firstly, respectively adding liquid medicine raw materials and solid medicine raw materials into a liquid medicine barrel 7 and a solid medicine barrel 9;
step 2: the quantitative liquid medicine raw materials are controlled to enter the mixing barrel 3 through the flow control valve 25 and are proportioned according to the liquid medicine raw materials;
and 3, step 3: starting the second motor 102 to feed the solid medicine raw materials into the mixing barrel 3;
and 4, step 4: starting the first motor 4 and the heating pipe 23 to heat and stir different kinds of medicine raw materials;
and 5: after the medicine raw materials react in the mixing barrel 3, the butterfly valve 26 is opened, and the medicine raw materials which are subjected to the mixing reaction flow into the top of the filter screen 15 in the box body 12;
step 6: starting the air cylinder 14, pushing the filter sieve 15 to extrude the supporting spring 16 to horizontally vibrate, enabling the liquid medicine to flow into the medicine box 18 through the material pipe 17, flow into the second drawer 19, and flow into the first drawer 13 through the part which does not pass through the material pipe 17;
and 7: the refrigerating pipe 24 is opened to cool the liquid medicine;
and 8: after the liquid medicine is cooled and crystallized, the finished medicine in the second drawer 19 is taken out.
Further, in step 3, the solid raw material enters the mixing barrel 3 and is brought in by the rotation of the spiral stirring shaft 103 to break up the powdery solid medicine raw material, so that the blockage caused by the agglomeration of the powder is avoided, the solid medicine raw material cannot flow out quantitatively, and the synthesis of the anticancer medicine is influenced.
Further, in step 4, the heating pipe 23 heats, so that the anticancer drug synthesis device has a heating mixed material at the same time, the anticancer drug synthesis device can stir and mix the anticancer drug more fully, the stirring can enable the solute to be dissolved in the solvent more quickly, and the heating can enable the mixed anticancer drug to be heated uniformly.
Furthermore, in step 5, the filter sieve 15 is a molecular sieve which is a crystalline silicate or aluminosilicate and formed by connecting silicon-oxygen tetrahedrons or aluminum-oxygen tetrahedrons through oxygen bridges, and is an aluminosilicate compound with cubic lattices, wherein silicon-aluminum is mainly connected through oxygen bridges to form an open framework structure, a plurality of pores with uniform pore diameters and cavities with large internal surface area are arranged in the structure, water molecules are continuously lost after heating, but the crystal framework structure is unchanged, so that a plurality of cavities with the same size are formed, the cavities are connected by a plurality of micropores with the same diameter, the diameters of the micropores are uniform, molecules with the diameter smaller than that of the pores can be adsorbed into the interiors of the pores, molecules with the diameter larger than that of the pores can be excluded, and molecules with different shapes, diameters, different molecules with different degrees of polarity, molecules with different boiling points and molecules with different degrees of saturation can be separated.
Further, in step 7, the cooling tube is used for cooling the separated liquid medicine, the content of dissolved substances in the liquid medicine is high, and the excessive dissolved substances are separated out from the liquid medicine in the form of solid crystals after the solubility is reduced through temperature reduction, so that the finished medicine is obtained through crystallization.
It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising a … …" does not exclude the presence of another identical element in a process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The synthesis and screening equipment of anti-cancer stem cell drug molecules comprises a base plate (1), and is characterized in that: the top of the bottom plate (1) is bolted with a frame body (2), the top of the frame body (2) is bolted with a mixing barrel (3), the top of the mixing barrel (3) is bolted with a first motor (4), the output end of the first motor (4) is bolted with a rotating rod (5), stirring sheets (6) are bolted on both sides of the rotating rod (5), the left side of the top of the mixing barrel (3) is bolted with a liquid medicine barrel (7), the right side of the liquid medicine barrel (7) is communicated with the top of the mixing barrel (3) with a pipe body (8), the right side of the top of the mixing barrel (3) is provided with a solid medicine barrel (9), a conveying mechanism (10) is communicated between the bottom of the solid medicine barrel (9) and the top of the mixing barrel (3), the bottom of the mixing barrel (3) is communicated with a discharge pipe (11), the lower end of the discharge pipe (11) is communicated with a box body (12), the front of the box body (12) is slidably connected with a first drawer (13), the left side of the inner wall of the box body (12) is connected with a bolt cylinder (14), the right side of the cylinder (14) is connected with a filter screen (15), and a filter screen (15) is connected with a right end of the filter screen (17) in a filter screen (15) in a clamping way, the right end of the material pipe (17) is communicated with a medicine box (18), and the right side of the medicine box (18) is connected with a second drawer (19) in a sliding mode.
2. The apparatus for synthesizing and screening anticancer stem cell drug molecules as claimed in claim 1, wherein: the conveying mechanism (10) comprises a conveying frame (101), a second motor (102) is bolted to the right side of the conveying frame (101), and an output end of the second motor (102) penetrates through the right side of the conveying frame (101) and is bolted to a spiral stirring shaft (103).
3. The apparatus for synthesizing and screening anticancer stem cell drug molecules as claimed in claim 1, wherein: the top of liquid medicine bucket (7) and solid medicine bucket (9) all communicates there is feeder hopper (20), and the top joint of feeder hopper (20) has shield (21).
4. The apparatus for synthesizing and screening anticancer stem cell drug molecules and the operation method thereof according to claim 1, characterized in that: slotted holes (22) are formed in the surface of the stirring sheet (6), a heating pipe (23) is bolted to the top of the inner wall of the mixing barrel (3), and a refrigerating pipe (24) is bolted to the top of the inner wall of the medicine box (18).
5. The apparatus for synthesizing and screening anticancer stem cell drug molecules as claimed in claim 1, wherein: flow control valve (25) are installed at the top of body (8), butterfly valve (26) are installed at the top of discharging pipe (11).
6. The operation method of the synthesis and screening equipment of the anti-cancer stem cell drug molecules is characterized in that: the method comprises the following steps:
step 1: firstly, respectively adding liquid medicine raw materials and solid medicine raw materials into a liquid medicine barrel (7) and a solid medicine barrel (9);
step 2: quantitative liquid medicine raw materials are controlled to enter the mixing barrel (3) through a flow control valve (25) according to the proportion of the liquid medicine raw materials;
and step 3: starting a second motor (102) to feed the solid medicine raw materials into the mixing barrel (3);
and 4, step 4: starting a first motor (4) and a heating pipe (23) to heat and stir different kinds of medicine raw materials;
and 5: after the medicine raw materials react in the mixing barrel (3), a butterfly valve (26) is opened, and the medicine raw materials which are mixed and reacted flow into the top of a filter screen (15) in the box body (12);
step 6: starting the air cylinder (14), pushing the filter screen (15) to extrude the supporting spring (16) to horizontally vibrate, enabling the liquid medicine to flow into the medicine box (18) through the material pipe (17), flow into the second drawer (19), and flow into the first drawer (13) through the part which does not pass through the material pipe (17);
and 7: the refrigerating pipe (24) is opened to cool the liquid medicine;
and 8: after the liquid medicine is cooled and crystallized, the finished product of the medicine in the second drawer (19) is taken out.
7. The method of claim 6, wherein the apparatus for synthesizing and screening the anticancer stem cell drug molecule comprises: in the step 3, the solid raw materials enter the mixing barrel (3) and need to be brought in by the rotation of the spiral stirring shaft (103) for scattering the powdery solid medicine raw materials, so that the blockage caused by the agglomeration of the powder is avoided, the solid medicine raw materials cannot flow out quantitatively, and the synthesis of the anticancer medicine is influenced.
8. The method of claim 6, wherein the apparatus for synthesizing and screening the anticancer stem cell drug molecule comprises: in the step 4, the heating pipe (23) is heated, so that the anticancer drug synthesis equipment is provided with a heating mixed material, the anticancer drug synthesis equipment is stirred and mixed more fully, the solute is dissolved in the solvent more quickly by stirring, and the mixed anticancer drug is heated uniformly by heating.
9. The method for operating an apparatus for synthesizing and screening anticancer stem cell drug molecules as claimed in claim 6, wherein: in the step 5, the filter sieve (15) adopts a molecular sieve which is crystalline silicate or aluminosilicate and is formed by connecting silicon-oxygen tetrahedrons or aluminum-oxygen tetrahedrons through oxygen bridge bonds, the molecular sieve is an aluminosilicate compound with cubic lattices, silicon-aluminum is mainly connected through oxygen bridges to form a hollow framework structure, a plurality of pore passages with uniform pore diameters and cavities with large internal surface areas are arranged in the structure, water molecules are continuously lost after heating, but the crystal framework structure is unchanged, a plurality of cavities with the same size are formed, the cavities are connected by a plurality of micropores with the same diameter, the diameters of the tiny pores are uniform, molecules with the diameter smaller than that of the pore passages can be adsorbed into the interior of the pores, molecules with the larger diameter than that of the pore passages are excluded, and molecules with different shapes, diameters, molecules with different polarity degrees, molecules with different boiling points and molecules with different saturation degrees can be separated.
10. The method of claim 6, wherein the apparatus for synthesizing and screening the anticancer stem cell drug molecule comprises: in the step 7, the cooling pipe is used for cooling the separated liquid medicine, the content of dissolved substances in the liquid medicine is high, and the excessive dissolved substances are separated out from the liquid medicine in a solid crystal form through temperature reduction and solubility reduction, so that the finished medicine is obtained through crystallization.
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| CN202110588527.0A CN115155485A (en) | 2021-05-28 | 2021-05-28 | Synthesis and screening equipment for anti-cancer stem cell drug molecules and operation method thereof |
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