CN211189163U - Concentrate device for extracting paclitaxel from taxus chinensis - Google Patents
Concentrate device for extracting paclitaxel from taxus chinensis Download PDFInfo
- Publication number
- CN211189163U CN211189163U CN201922097240.9U CN201922097240U CN211189163U CN 211189163 U CN211189163 U CN 211189163U CN 201922097240 U CN201922097240 U CN 201922097240U CN 211189163 U CN211189163 U CN 211189163U
- Authority
- CN
- China
- Prior art keywords
- outlet pipe
- tank body
- concentration tank
- concentration
- taxus chinensis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 241001149649 Taxus wallichiana var. chinensis Species 0.000 title claims abstract description 17
- 229930012538 Paclitaxel Natural products 0.000 title claims abstract description 14
- 229960001592 paclitaxel Drugs 0.000 title claims abstract description 14
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 title claims abstract description 14
- 239000012141 concentrate Substances 0.000 title abstract description 6
- 239000002904 solvent Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000010438 heat treatment Methods 0.000 claims abstract description 10
- 239000000523 sample Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 9
- 238000005485 electric heating Methods 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 2
- 238000002386 leaching Methods 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 24
- 229940123237 Taxane Drugs 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Images
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- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
The utility model relates to a chinese yew deep-processing technology field, concretely relates to draw enrichment facility of taxol from chinese yew. This enrichment facility is including setting up the concentrated jar of body on the support, its top of the concentrated jar of body is equipped with the feed inlet, its below is equipped with the concentrate outlet pipe, still including setting up the electric mixer in the concentrated jar of body, the external temperature detect switch of temperature control probe and concentrated jar, its top of the concentrated jar of body is equipped with vacuum pump and steam outlet pipe, its inner wall is equipped with the cover that presss from both sides that is used for the heating, it is provided with the electrothermal tube in the cover to press from both sides, the steam outlet pipe has connected gradually the condenser, oil water separator and solvent jar, concentrate outlet pipe below is connected with the extract collection tank, temperature detect. The utility model provides a current concentrated pot can not be to leaching solvent recycle and the not wayward problem of temperature, and can improve concentration efficiency.
Description
Technical Field
The utility model relates to a chinese yew deep-processing technology field, concretely relates to draw enrichment facility of taxol from chinese yew.
Background
In the paclitaxel extraction production, after the branches and leaves of the taxus chinensis are generally extracted, the branch and leaf extract liquid produced in the extraction process is heated and concentrated through a concentration pot, and finally an extract product is obtained. However, in the concentration process of the existing concentration pot, a part of the leaching solvent is discharged from the exhaust pipe of the concentration pot along with the water vapor and is not effectively recovered, so that the solvent loss is large and the production cost is high; secondly, the temperature is not easy to control during heating, so that the taxane substance is easy to destroy and degrade at high temperature (the temperature is not suitable to exceed 80 ℃).
SUMMERY OF THE UTILITY MODEL
The utility model discloses to prior art's not enough, provide a reliable performance and draw enrichment facility of taxol from chinese yew, solved current concentration pot and can not be to leaching solvent recycle and the not wayward problem of temperature, and can improve concentration efficiency.
The technical scheme of the utility model is realized like this: the utility model provides a follow enrichment facility that taxol was drawed to chinese yew, is including setting up the concentrated jar of body on the support, its top of the concentrated jar of body is equipped with the feed inlet, and its below is equipped with the concentrate outlet pipe, its characterized in that, still including setting up at the external temperature detect switch of internal electric mixer, temperature detect probe and the concentrated jar of concentrated jar, its top of the concentrated jar of body is equipped with vacuum pump and steam outlet pipe, and its inner wall is equipped with the cover that presss from both sides that is used for the heating, it is provided with the electrothermal tube in the cover to press from both sides, the steam outlet pipe has connected gradually condenser, oil water separator and solvent jar, concentrate outlet pipe below is connected with the extract collection tank, temperature.
And a filtering membrane is arranged on a pipeline between the steam outlet pipe and the condenser.
The electric stirrer comprises a speed reduction motor at the top of the concentration tank body, the speed reduction motor is connected with a stirring shaft extending into the interior of the concentration tank body, and stirring blades are arranged on the stirring shaft.
The outer wall of the concentrating tank body is coated with a heat-insulating layer.
And a pressure gauge is arranged on the concentration tank body.
The utility model provides an existing defect among the background art, have following beneficial effect:
the utility model provides a follow enrichment facility that taxol was drawed to chinese yew simple structure is reasonable, has solved current concentration pot and can not be to the not wayward problem of leaching solvent recycle and temperature, and can improve concentration efficiency. The utility model discloses a vacuum pump extraction vacuum has improved concentration efficiency, reduces the boiling point of material, and solvent methyl alcohol boils the back under vacuum low temperature to through the condenser condensation, separate water and solvent through oil water separator again, the methanol solvent who finally obtains, thereby realized solvent recycle. Through the linkage of the temperature sensing probe and the temperature control switch, the heating temperature can be controlled within a preset temperature, and the damage and the degradation of the taxane active ingredients caused by high temperature are avoided. In the heating process, the leaching liquor is stirred by an electric stirrer to be uniformly heated and concentrated, and finally a high-quality extract product is obtained.
Drawings
Fig. 1 is a schematic structural view of the present invention;
in the figure: 1-support, 2-concentration tank body, 3-jacket, 4-electrothermal tube, 5-electric stirrer, 6-vacuum pump, 7-condenser, 8-oil-water separator, 9-solvent tank, 10-feed inlet, 11-concentrated solution outlet pipe, 12-extract collecting tank, 13-steam outlet pipe, 14-filtering membrane, 15-temperature control probe, 16-temperature control switch and 17-pressure gauge.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
An embodiment of a concentration device for extracting paclitaxel from taxus chinensis as shown in fig. 1 comprises a concentration tank body 2 arranged on a support 1, a feed inlet 10 is arranged above the concentration tank body 2, a concentrated solution outlet pipe 11 is arranged below the concentration tank body, the concentration device further comprises an electric stirrer 5 arranged in the concentration tank body 2, a temperature control probe 15 and a temperature control switch 16 outside the concentration tank body 2, a vacuum pump 6 and a steam outlet pipe 13 are arranged at the top of the concentration tank body 2, a jacket 3 for heating is arranged on the inner wall of the concentration tank body, an electric heating pipe 4 is arranged in the jacket 3, the steam outlet pipe 13 is sequentially connected with a condenser 7, an oil-water separator 8 and a solvent tank 9, an extract collection tank 12 is connected below the concentrated solution outlet pipe 11, and the temperature control switch 16 is respectively electrically connected. A filter membrane 14 is mounted on the pipe between the vapor outlet pipe 13 and the condenser 7. The electric stirrer 5 comprises a speed reducing motor at the top of the concentration tank body 2, the speed reducing motor is connected with a stirring shaft extending into the concentration tank body 2, and stirring blades are arranged on the stirring shaft. The outer wall of the concentration tank body 2 is coated with a heat preservation layer. The concentration tank body 2 is provided with a pressure gauge 17.
The utility model discloses a working process is: during operation, firstly, the vacuum pump 6 of the vacuumizing device is used for evacuating the air in the concentrating tank body 2, so that the concentrating efficiency is improved. Then the leaching liquor of the branches and leaves of the taxus chinensis is pumped into the concentration tank body 2 through the feed inlet 10. Meanwhile, the electric heating tube 4 is started to raise the temperature in the jacket 3, so that the leaching liquor in the tank body is heated and concentrated. In the vacuum environment, the boiling points of the methanol solvent and water are lowered, and water vapor is discharged from the condensed water outlet pipe 8. After the solvent methanol is boiled at low temperature, the solvent methanol is discharged from a steam outlet pipe 13 as steam, condensed by a condenser 7 and separated by an oil-water separator 8, and finally the obtained methanol solvent flows into a solvent tank 9 to be collected, so that the solvent is recycled. In the heating process, the leaching liquor is stirred by the electric stirrer 5, so that the temperature is uniformly increased. When the concentration of the methanol recovered in the solvent tank 9 is less than 20 degrees, the separation and recovery of the methanol solvent are completed, and finally an extract product is obtained. Finally, the concentrated solution is discharged out of the tube 11, and the paste is discharged into a paste collection tank 12 when the concentrated solution is hot. In the concentration process, once the temperature control probe 15 detects that the temperature in the tank exceeds the preset value (80 ℃), a signal is sent to the temperature control switch 16, the temperature control switch 16 cuts off the power supply of the electric heating tube 4, heating is stopped, and the damage and degradation of the taxane active ingredients caused by high temperature are avoided.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. A concentration device for extracting paclitaxel from Taxus chinensis comprises a concentration tank body (2) arranged on a support (1), a feed inlet (10) is arranged above the concentration tank body (2), a concentrated solution outlet pipe (11) is arranged below the device, and the device is characterized by also comprising an electric stirrer (5) arranged in the concentration tank body (2), a temperature control probe (15) and a temperature control switch (16) outside the concentration tank body (2), the top of the concentration tank body (2) is provided with a vacuum pump (6) and a steam outlet pipe (13), the inner wall of the heating tube is provided with a jacket (3) for heating, an electric heating tube (4) is arranged in the jacket (3), the steam outlet pipe (13) is sequentially connected with a condenser (7), an oil-water separator (8) and a solvent tank (9), an extract collecting tank (12) is connected below the concentrated solution outlet pipe (11), the temperature control switch (16) is respectively and electrically connected with the electric heating tube (4) and the temperature control probe (15).
2. The apparatus for concentrating paclitaxel extracted from taxus chinensis according to claim 1, wherein: and a filtering membrane (14) is arranged on a pipeline between the steam outlet pipe (13) and the condenser (7).
3. The concentration device for extracting paclitaxel from taxus chinensis according to claim 1 or 2, wherein: the electric stirrer (5) comprises a speed reduction motor arranged at the top of the concentration tank body (2), the speed reduction motor is connected with a stirring shaft extending into the concentration tank body (2), and stirring blades are arranged on the stirring shaft.
4. The apparatus for concentrating paclitaxel extracted from taxus chinensis according to claim 3, wherein: the outer wall of the concentration tank body (2) is coated with a heat preservation layer.
5. The apparatus for concentrating paclitaxel extracted from taxus chinensis according to claim 4, wherein: and a pressure gauge (17) is arranged on the concentration tank body (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922097240.9U CN211189163U (en) | 2019-11-28 | 2019-11-28 | Concentrate device for extracting paclitaxel from taxus chinensis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922097240.9U CN211189163U (en) | 2019-11-28 | 2019-11-28 | Concentrate device for extracting paclitaxel from taxus chinensis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211189163U true CN211189163U (en) | 2020-08-07 |
Family
ID=71847684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922097240.9U Expired - Fee Related CN211189163U (en) | 2019-11-28 | 2019-11-28 | Concentrate device for extracting paclitaxel from taxus chinensis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211189163U (en) |
-
2019
- 2019-11-28 CN CN201922097240.9U patent/CN211189163U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20200807 |