CN211179851U - Carousel formula ally oneself with more and examine device and system - Google Patents
Carousel formula ally oneself with more and examine device and system Download PDFInfo
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- CN211179851U CN211179851U CN201921703114.7U CN201921703114U CN211179851U CN 211179851 U CN211179851 U CN 211179851U CN 201921703114 U CN201921703114 U CN 201921703114U CN 211179851 U CN211179851 U CN 211179851U
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Abstract
The utility model belongs to the technical field of the luminous immunodetection of micro-fluidic chip, especially, relate to a carousel formula ally oneself with more and examine device and system. The multi-joint inspection device comprises: the magnetic particle light-emitting micro-fluidic chip comprises a chip body, wherein a sample adding part is arranged on the chip body; the carousel is equipped with the application of sample pond that supplies the sample to add and a plurality of defeated appearance passageway that communicates with the application of sample pond respectively on the carousel, and each is defeated appearance passageway mutual independence sets up to each is defeated appearance passageway and is mutually connected mutually with the application of sample portion that corresponds respectively, and the at least one end of defeated appearance passageway is equipped with the blanking cover. When the carousel rotated, the sample in the application of sample pond on the carousel can be because centrifugal force evenly separated each defeated appearance passageway to from defeated appearance passageway flow direction application of sample portion, so can once only add more samples that supply to detect in the application of sample pond, flow to each magnetic particle luminescence micro-fluidic chip with the sample simultaneously again respectively, need not artifical manual operation one by one, improved detection efficiency greatly.
Description
Technical Field
The utility model belongs to the technical field of the luminous immunodetection of micro-fluidic chip, especially, relate to a carousel formula ally oneself with more and examine device and system.
Background
Currently, there are two major trends In Vitro Diagnostics (IVD): one is automatic and integrated, namely, the high-precision disease analysis and diagnosis is realized by utilizing full-automatic and high-sensitivity large-scale instruments and equipment of a central laboratory matched with a large-scale hospital; the other type of miniaturization and bedside miniaturization is realized, namely, the rapid analysis and diagnosis on site is realized through handheld small simple equipment. However, small hospitals are not capital intensive, have a small sample size, and are not suitable for purchasing expensive large equipment. Therefore, most of the rapid detection equipment adopted by hospitals at the present stage mainly comprises test strips and corollary equipment thereof, but the test strips can only realize qualitative or semi-quantitative detection, and have the advantages of low detection sensitivity, poor specificity, poor repeatability and obvious interference. Due to the fact that China has a large population, aging is aggravated, the disease incidence is increased sharply, and dependence on large hospitals is overwhelmed. Therefore, the development of a rapid detection method and equipment which are simple and convenient to operate, high in sensitivity, good in repeatability and accurate in quantification becomes urgent.
The micro-fluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in the biological, chemical and medical analysis process into a micron-scale chip, and automatically completes the whole analysis process. Due to its great potential in the fields of biology, chemistry, medicine, etc., it has been developed into a research field with multiple interdisciplinary disciplines of biology, chemistry, medicine, fluid, material, machinery, etc., and is applied to the fields of biomedical research, biochemical detection, judicial appraisal, etc. The prior microfluidic chip needs to perform an operation before performing luminescence immunoassay, that is, adding a sample into the microfluidic chip. However, the existing sample adding method only leads the samples into each microfluidic chip one by one manually or mechanically and automatically. When the number of samples is large and the joint inspection is required to be simultaneously realized by a plurality of micro-fluidic chips, if the samples are still respectively introduced into the corresponding micro-fluidic chips one by one, and then the detection is carried out by one pair of micro-fluidic chips, the detection efficiency is low, and the purpose of simultaneously carrying out the sample adding detection on a large scale cannot be achieved.
SUMMERY OF THE UTILITY MODEL
The embodiment of the utility model provides a carousel formula ally oneself with more examines device and system aims at solving among the current sample needs the one-by-one to add micro-fluidic chip, and detect micro-fluidic chip respectively, lead to the problem of inefficiency.
The embodiment of the utility model provides a realize like this, provide a carousel formula ally oneself with more and examine the device, many ally oneself with and examine the device and include: the magnetic particle light-emitting micro-fluidic chip comprises a chip body, wherein a sample adding part is arranged on the chip body; the carousel, be equipped with on the carousel supply the sample loading pond that the sample added and a plurality of respectively with the defeated appearance passageway of sample loading pond intercommunication, each defeated appearance passageway mutual independence sets up to each defeated appearance passageway interconnects mutually with the sample loading portion that corresponds respectively, the at least one end of defeated appearance passageway is equipped with the blanking cover.
Still further, the multi-joint inspection device further comprises: and the connection area is provided with a connection channel which is respectively communicated with the sample adding part and the sample conveying channel.
Still further, the carousel is provided integrally with the docking area.
Furthermore, a buffer pool is arranged on the connection area, and the width of the buffer pool is larger than that of the connection channel.
Still further, a first side of the docking area extends toward a second side and is disposed with a gradually decreasing width, and the first side is disposed adjacent to the chip body.
Furthermore, the connection channel is provided with a sharp part at one end close to the sample adding part.
Furthermore, the turntable is circular, the sample adding pool is circular with a smaller diameter than the turntable, and the sample conveying channel is arranged between the outer wall of the turntable and the outer wall of the sample adding pool.
The utility model also provides a many examining systems of carousel formula, many examining systems include: the multi-gang inspection device is described above; the driving device is used for driving the turntable to rotate; under the drive of the driving device, the sample feeding pool of the turntable separates the samples to each sample feeding channel, and the samples enter the sample feeding part from the sample feeding channels.
Further, the driving device is a rotating motor.
The utility model has the advantages of providing a carousel-type multi-link detection device and system, which is provided with a carousel and at least one magnetic particle luminous micro-fluidic chip connected with the carousel, wherein the sample delivery channel on the carousel is connected with the sample adding part on the magnetic particle luminous micro-fluidic chip, when the carousel rotates, the sample in the sample adding pool on the carousel can be uniformly separated into each sample delivery channel due to centrifugal force and flows to the sample adding part from the sample delivery channel, so that more samples for detection can be added into the sample adding pool at one time, and then the samples flow to each magnetic particle luminous micro-fluidic chip simultaneously, manual operation is not needed, each magnetic particle luminous micro-fluidic chip is also arranged on the carousel, the purpose of joint detection of a plurality of magnetic particle luminous micro-fluidic chips can be realized, the detection efficiency is greatly improved, and the sample delivery channels are provided with blocking covers, when the corresponding position of the sample conveying channel is not connected with the magnetic particle luminous micro-fluidic chip, the blocking cover can seal the sample conveying channel, so that the loss of the sample is avoided.
Drawings
Fig. 1 is a schematic diagram of a multi-gang inspection device provided by an embodiment of the present invention;
fig. 2 is a schematic view of a turntable provided in an embodiment of the present invention;
fig. 3 is a schematic diagram of a magnetic particle luminescent microfluidic chip according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Compared with the prior art, the utility model relates to a carousel formula many examine equipment and system more, be equipped with carousel 2 and at least one magnetic particle luminescence micro-fluidic chip 1 connected with carousel 2, defeated appearance passageway 22 on carousel 2 and the portion of application of sample 111 on the magnetic particle luminescence micro-fluidic chip 1 interconnect, when carousel 2 rotates, the sample in the application of sample pond 21 on carousel 2 can be because of centrifugal force evenly separate to each defeated appearance passageway 22, and flow to portion of application of sample 111 from defeated appearance passageway 22, so can once only add the more sample that supplies the detection in application of sample pond 21, respectively flow to each magnetic particle luminescence micro-fluidic chip 1 simultaneously with the sample again, need not artifical manual operation one by one, each magnetic particle luminescence micro-fluidic chip still establishes jointly on carousel 2, can realize the purpose that a plurality of magnetic particle luminescence micro-fluidic chips jointly examined, greatly improved detection efficiency, and, the sample transportation channel 22 is provided with a blocking cover, when the corresponding position of the sample transportation channel 22 is not connected with the magnetic particle luminescent microfluidic chip 1, the blocking cover can close the sample transportation channel 22, so that the loss of the sample is avoided.
Example one
Referring to fig. 1 to 3, in the first embodiment, a carousel type multi-gang inspection apparatus is provided, and the multi-gang inspection apparatus includes:
the magnetic particle light-emitting micro-fluidic chip 1 comprises a chip body 11, wherein a sample adding part 111 is arranged on the chip body 11; carousel 2, carousel 2 are equipped with the application of sample pond 21 that supplies the sample to add and a plurality of defeated appearance passageway 22 that communicates with application of sample pond 21 respectively, and each defeated appearance passageway 22 sets up each other independently to each defeated appearance passageway 22 respectively with the application of sample portion 111 interconnect that corresponds, at least one end of defeated appearance passageway 22 is equipped with the blanking cover.
In order to avoid the contact between the sample and the external environment, the sample adding pool 21 of the turntable 2 can be provided with an open or closed cover, after the cover is opened, an external sample adding device (such as a needle tube) can penetrate through a through hole formed after the cover is opened, the sample is added into the sample adding pool 21 by the sample adding device, and then the cover is closed, so that the sample and the external environment can be isolated from each other. Further, the size of lid can set up to be less than the size of application of sample pond 21 far away, and so, the through-hole size that forms after the lid is opened is also less, more can avoid external environment's impurity to get into the cavity between lid and the application of sample pond 21, and the application of sample device sees through the through-hole again and adds the sample in application of sample pond 21. Of course, the sample adding cell 21 can also be directly exposed to the external environment, and the sample adding device directly adds the sample to the sample adding cell 21.
After the sample is added into the sample adding pool 21 by the sample adding device, the turntable 2 is rotated, and the turntable 2 can be controlled to move at a constant speed, at an accelerated speed or at a decelerated speed, so that the turntable 2 can realize circular rotation. Due to the action of centrifugal force, the samples in the sample adding pool 21 can be uniformly separated and enter each sample conveying channel 22, and the sample conveying channels 22 are independently arranged, so that the phenomenon of sample crossing can be avoided. Along with carousel 2's continuation rotation, because defeated appearance passageway 22 is equipped with the direction that sets up, can play the guide effect to the sample, the sample can follow defeated appearance passageway 22 and get into in proper order during the corresponding application of sample portion 111 to get into chip body 11 smoothly. Alternatively, the diameters of the sample transport channels 22 are uniform, so that the samples flowing from the sample transport channels 22 to the sample addition part 111 can be ensured to be uniform.
It is worth mentioning that the magnetic particle luminous micro-fluidic chip 1 and the turntable 2 are detachably arranged, when an operator separates the sample adding part 111 from the sample conveying channel 22, the magnetic particle luminous micro-fluidic chip 1 and the turntable 2 can be detached, and at the moment, the blocking cover can seal the sample conveying channel 22, so that the subsequent sample is prevented from flowing out. When the operator connects the sample adding part 111 to the sample adding channel 22, the magnetic particle luminescent microfluidic chip 1 and the rotary disk 2 can be combined.
To the blanking cover, can set up and be close to application of sample pond 21 one end at defeated appearance passageway 22, when defeated appearance passageway 22 does not correspond and connect application of sample portion 111, operating personnel can close the blanking cover by oneself for the blanking cover seals defeated appearance passageway 22, even follow-up carousel 2 is rotatory, and the sample also can not get into from application of sample pond 21 and defeated appearance passageway 22, can avoid the waste of sample. When the sample-feeding channel 22 is correspondingly connected with the sample-feeding part 111, the operator opens the blocking cover by himself, the subsequent rotary disc 2 rotates, and the sample can enter the sample-feeding channel 22 from the sample-feeding pool 21 and enter the sample-feeding part 111. Or, the blanking cover can set up and be close to application of sample portion 111 one end at defeated appearance passageway 22, when defeated appearance passageway 22 does not correspond and connect application of sample portion 111, operating personnel can close the blanking cover by oneself, operating personnel can open the blanking cover by oneself, even follow-up carousel 2 is rotatory, the sample also only can flow in defeated appearance passageway 22, nevertheless can not flow out from defeated appearance passageway 22, can avoid the waste of sample, and, can help the sample to separate more evenly in application of sample pond 21. When the sample-feeding channel 22 is correspondingly connected with the sample-feeding part 111, the operator opens the blocking cover by himself, the subsequent rotary disc 2 rotates, and the sample can enter the sample-feeding channel 22 from the sample-feeding pool 21 and enter the sample-feeding part 111.
Example two
Referring to fig. 1 and 3, on the basis of the first embodiment, the multi-split inspection apparatus of the second embodiment further includes:
and a connection area 22 connected with the turntable, wherein the connection area 22 is provided with a connection channel 221 respectively communicated with the sample adding part 111 and the sample conveying channel 22.
After the rotating disc 2 rotates, the sample in the sample adding pool 21 is introduced into each sample adding channel 22, then enters each corresponding connecting channel 221 from the sample adding channel 22, and finally enters each corresponding sample adding part 111 from the connecting channel 221, so as to smoothly enter the magnetic particle light-emitting microfluidic chip 1. It should be noted that the sample-transporting channel 22 of the turntable 2 is communicated with the docking channel 221 of the docking area 22, the docking channel 221 is further communicated with the sample-loading part 111 of the chip main body, and the sample-transporting channel 22 is not directly communicated with the sample-loading part 111, so that the sample separation process is more reliable.
EXAMPLE III
Referring to fig. 1, on the basis of the second embodiment, the connection area 22 of the third embodiment is integrally disposed with the turntable 2, so that the processing cost is reduced, and the overall firmness is greatly improved.
Example four
Referring to fig. 1 and fig. 3, on the basis of the second embodiment, the buffer pool 222 is disposed on the docking area 22 of the fourth embodiment, and the width of the buffer pool 222 is greater than the width of the docking channel 221.
Wherein the buffer pool 222 is optionally arranged at the middle position of the docking passage 221. When the sample enters the docking channel 221 from the sample adding pool 21, the sample moves along the guiding function of the docking channel 221, and along with the movement of the sample, the sample enters the buffer pool 222 to obtain a certain buffering function, and then flows out of the buffer pool 222 to continue to move along the guiding function of the docking channel 221.
EXAMPLE five
Referring to fig. 1 and fig. 3, on the basis of the second embodiment, the first side of the connection region 22 of the fifth embodiment extends toward the second side and is gradually reduced in width, and the first side is disposed adjacent to the chip main body.
If the connection area 22 is only provided with the connection channel 221, the connection channel 221 is a long strip-shaped channel, which is relatively long and thin, and as the turntable 2 rotates, the connection channel 221 also rotates along with the turntable 2, and the connection channel 221 receives a large acting force during rotation, which easily causes the connection channel 221 to bend, affects the transportation of the sample, and greatly reduces the service life of the connection channel 221. Therefore, the connection region 22 extends from the first side to the second side and has a gradually reduced width, so that the stability of the device and the reliability of the connection between the turntable 2 and the magnetic particle light-emitting microfluidic chip 1 can be greatly improved, and even if the turntable 2 rotates at a high speed, the magnetic particle light-emitting microfluidic chip 1 can also stably rotate along with the rotation of the turntable 2.
The first side of the connection region 22 extends toward the second side and is gradually reduced in width to form a triangle, when the turntable 2 is connected with the magnetic particle luminescent microfluidic chip 1, the second side of the connection region 22 may abut against the sample transportation channel 22, or the second side of the connection region 22 is far away from the sample transportation channel 22 and only the connection channel 221 is connected with the sample transportation channel 22.
EXAMPLE six
Referring to fig. 1 and fig. 3, in addition to the second embodiment, the docking channel 221 of the sixth embodiment is provided with a sharp portion at an end close to the sample adding portion 111, and a sharp end of the sharp portion faces the magnetic particle luminescent microfluidic chip 1. Because the sample adding part 111 on the chip main body 11 is a through groove, when the magnetic particle luminescent microfluidic chip 1 moves towards the direction of the turntable 2, the sharp part can be inserted into the sample adding part 111, so that the mutual connection between the sample adding part 111 and the connection channel 221 is realized. When the magnetic particle light-emitting micro-fluidic chip 1 is separated from the turntable 2, the sample adding part 111 and the sharp part are separated from each other. It should be noted that the sharp portion may be provided with a through hole so that the sample can flow from the connecting channel 221 to the sample adding portion 111, or the sharp portion may be configured to be capable of being clamped into the sample adding portion 111, and a gap may be left, so that the sample can flow into the sample adding portion 111 from the gap.
EXAMPLE seven
Referring to fig. 1 and 2, in the seventh embodiment, the turntable 2 is circular, the sample adding well 21 is circular with a smaller diameter than that of the turntable 2, and the sample adding channel 22 is disposed between the outer wall of the turntable 2 and the outer wall of the sample adding well 21. Because defeated appearance passageway 22 is for extending the passageway that sets up along application of sample pond 21, will defeated appearance passageway 22 establishes between the outer wall of carousel 2 and the outer wall of application of sample pond 21, can improve the stability and the reliability of carousel 2 greatly, also can improve the quality of use of defeated appearance passageway 22 greatly, when carousel 2 is high-speed rotatory, defeated appearance passageway 22 also can the steady rotation equally, and can not take place the phenomenon of atress bending.
Example eight
This embodiment nine provides a many online inspection systems of carousel formula, and many online inspection systems include: a multi-gang inspection device as in embodiments one to seven; and the driving device is used for driving the turntable 2 to rotate.
The turntable 2 is rotated by the driving device, the sample cell 21 of the turntable 2 separates the sample into the sample transport channels 22, and the sample enters the sample loading portion 111 from the sample transport channels 22.
Example nine
In addition to the eighth embodiment, the driving device of the ninth embodiment is a rotating electric machine. Rotating electrical machines, which convert electrical energy into mechanical energy, essentially comprise an electromagnet winding or distributed stator winding for generating a magnetic field and a rotating armature or rotor. Under the action of the rotating magnetic field of the stator winding, current passes through the aluminum frame and is driven by the magnetic field to rotate. Of course, the driving device may be other devices as long as the driving of the rotation of the turntable 2 can be realized, and the details are not repeated herein.
The above description is only exemplary of the present invention and should not be construed as limiting the present invention, and any modifications, equivalents and improvements made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (9)
1. The utility model provides a carousel formula ally oneself with examines device more which characterized in that, the many allies oneself with examines the device and include:
the magnetic particle light-emitting micro-fluidic chip comprises a chip body, wherein a sample adding part is arranged on the chip body;
the carousel, be equipped with on the carousel supply the sample loading pond that the sample added and a plurality of respectively with the defeated appearance passageway of sample loading pond intercommunication, each defeated appearance passageway mutual independence sets up to each defeated appearance passageway interconnects mutually with the sample loading portion that corresponds respectively, the at least one end of defeated appearance passageway is equipped with the blanking cover.
2. The multi-gang inspection apparatus of claim 1, further comprising:
and the connection area is provided with a connection channel which is respectively communicated with the sample adding part and the sample conveying channel.
3. A multi-gang inspection apparatus as claimed in claim 2, wherein the turntable is integrally provided with the docking area.
4. The multi-gang inspection device as claimed in claim 2, wherein a buffer pool is provided on the docking area, and the width of the buffer pool is greater than the width of the docking channel.
5. The multi-gang inspection device of claim 2, wherein a first side of the docking area extends toward a second side and is disposed with a gradually decreasing width, the first side being disposed adjacent to the chip body.
6. The multi-test device as claimed in claim 2, wherein said docking channel has a sharp portion at an end thereof adjacent to said sample loading portion.
7. The multi-test device as claimed in claim 1, wherein the carousel is configured as a circle, the sample loading wells are configured as a circle having a smaller diameter than the carousel, and the sample loading channels are disposed between an outer wall of the carousel and an outer wall of the sample loading wells.
8. The utility model provides a many joint inspection systems of carousel formula which characterized in that, many joint inspection systems include:
a multiple inspection apparatus as claimed in any one of claims 1 to 7;
the driving device is used for driving the turntable to rotate;
under the drive of the driving device, the sample feeding pool of the turntable separates the samples to each sample feeding channel, and the samples enter the sample feeding part from the sample feeding channels.
9. The multi-gang inspection system of claim 8, wherein the driving means is a rotary motor.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921703114.7U CN211179851U (en) | 2019-10-11 | 2019-10-11 | Carousel formula ally oneself with more and examine device and system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921703114.7U CN211179851U (en) | 2019-10-11 | 2019-10-11 | Carousel formula ally oneself with more and examine device and system |
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| CN211179851U true CN211179851U (en) | 2020-08-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110646608A (en) * | 2019-10-11 | 2020-01-03 | 深圳华迈兴微医疗科技有限公司 | Carousel formula ally oneself with more and examine device and system |
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2019
- 2019-10-11 CN CN201921703114.7U patent/CN211179851U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110646608A (en) * | 2019-10-11 | 2020-01-03 | 深圳华迈兴微医疗科技有限公司 | Carousel formula ally oneself with more and examine device and system |
| WO2021068911A1 (en) * | 2019-10-11 | 2021-04-15 | 深圳华迈兴微医疗科技有限公司 | Rotating disc type multiple measurement device and system |
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