CN211096518U - Closed multifunctional extracorporeal circulation pipeline - Google Patents
Closed multifunctional extracorporeal circulation pipeline Download PDFInfo
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- CN211096518U CN211096518U CN201921175565.8U CN201921175565U CN211096518U CN 211096518 U CN211096518 U CN 211096518U CN 201921175565 U CN201921175565 U CN 201921175565U CN 211096518 U CN211096518 U CN 211096518U
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- pipeline
- branch
- circuit
- protein
- extracorporeal
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- 230000010412 perfusion Effects 0.000 claims abstract description 23
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 22
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 22
- 238000000502 dialysis Methods 0.000 claims abstract description 17
- 238000001179 sorption measurement Methods 0.000 claims description 18
- 238000005070 sampling Methods 0.000 claims description 8
- 239000002699 waste material Substances 0.000 claims description 7
- 230000037452 priming Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 2
- 230000001681 protective effect Effects 0.000 claims description 2
- 238000011067 equilibration Methods 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 17
- 230000008081 blood perfusion Effects 0.000 abstract description 8
- 238000000034 method Methods 0.000 abstract description 8
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 239000007788 liquid Substances 0.000 description 10
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 230000000740 bleeding effect Effects 0.000 description 5
- 238000010828 elution Methods 0.000 description 5
- 238000001631 haemodialysis Methods 0.000 description 4
- 230000000322 hemodialysis Effects 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000002504 physiological saline solution Substances 0.000 description 3
- 238000011284 combination treatment Methods 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- 230000001951 hemoperfusion Effects 0.000 description 2
- 238000002616 plasmapheresis Methods 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 208000037157 Azotemia Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
Images
Abstract
The utility model discloses a multi-functional extrinsic cycle pipeline of closed, its characterized in that: the device comprises 3 main pipelines and 8 branch pipelines, and the circulating pipeline can be simultaneously used for protein A immunoadsorption treatment and whole blood perfusion and dialysis treatment modes. Can realize the separate pre-charging of the dialysis unit, the plasma replacement unit or the perfusion unit; under the treatment mode of whole blood perfusion plus dialysis, the pipeline does not need to be disassembled after the whole blood perfusion is carried out for two hours, so that the infection caused by the contact of the pipeline and the external environment in the treatment process can be avoided; under the protein A immunoadsorption treatment mode, the protein A immunoadsorption column capable of being repeatedly used can be eluted and reused on line.
Description
Technical Field
The utility model belongs to the technical field of medical instrument and specifically relates to a closed blood purifies uses multi-functional extracorporeal circulation connecting pipe.
Background
At present, the common modes of blood purification in China are hemodialysis, hemoperfusion and hemofiltration. In particular, the hemoperfusion mainly includes a combination of whole blood perfusion adsorption and hemodialysis and a combination of plasma separation and plasma perfusion adsorption, for example, the combination of plasma separation and plasma perfusion adsorption is used in the treatment of autoimmune diseases by protein A immunoadsorption, and the combination of whole blood perfusion adsorption and hemodialysis is basically used in the field of uremia. The main problems faced are: 1. there is no connecting line available for simultaneous treatment in both combinations. 2. To remove the cartridge two hours after whole blood perfusion, the connecting tubing must be reconnected for the next dialysis procedure. 3. Separate priming of the dialysis unit, the plasmapheresis unit or the perfusion unit cannot be achieved. 4. There is no way to complete elution reuse of the cartridge on-line for a reusable cartridge.
Disclosure of Invention
The to-be-solved technical problem of the utility model lies in providing one kind and both having been applicable to the plasma separation and adding the absorbent combination treatment mode of plasma perfusion, be applicable to the hemodialysis again and add the general connecting line of the combination treatment mode of whole blood perfusion to can carry out the elution and the used repeatedly of repeatedly usable perfusion ware. Realize that one set of connecting line is multi-purpose, avoid dismantling the in-process of perfusion ware simultaneously and contact with the air.
The utility model discloses a multi-functional extrinsic cycle pipeline of closed, its characterized in that: the pipeline comprises 3 main pipelines, a pipeline 3, a pipeline 6, a pipeline 7 and 8 branch pipelines, wherein the branch pipelines comprise a branch pipeline 1, a branch pipeline 2, a branch pipeline 4, a branch pipeline 5, a branch pipeline 8, a branch pipeline 9, a branch pipeline 10 and a branch pipeline 11; the branch pipeline 1, the branch pipeline 2 and the pipeline 3 are communicated with each other; the branch pipeline 1 is connected with a plasma separator adapter 16 and further connected with a plasma separator 15, and the branch pipeline 2 is connected with the arterial end of a dialysis pipeline; the end part of the pipeline 6 is connected with the perfusion device 13, the other end of the pipeline is communicated with the pipeline 3, and a section of pump pipe 62 is designed in the middle of the pipeline 6; the branch pipeline 8, the branch pipeline 9, the branch pipeline 10 and the pipeline 6 are communicated with each other; one end of the pipeline 7 is connected with the perfusion device 13, the other end of the pipeline is communicated with the pipeline 3, and the branch pipeline 11 is communicated with the pipeline 7; the pipeline 3, the branch pipeline 4 and the branch pipeline 5 are communicated with each other; the branch line 4 is connected with a hemodialyzer 14; the branch pipeline 5 is connected with the dialysis pipeline venous pot interface; each pipeline is provided with a pipeline clamp, wherein two pipeline clamps are arranged between the pipeline 6 and the pipeline 7 of the pipeline 3; the joints at the end parts of the pipelines are provided with protective caps.
The pipelines 3 and 6 and the pipelines 3 and 7 are connected through T-shaped tee joints and are provided with pipeline clamps 31, 32, 61 and 71.
The branch pipeline 1 and the branch pipeline 2 are connected with the pipeline 3 through a Y-shaped tee joint and are provided with pipeline clamps 12 and 22, and internal threads 11 and 21 are arranged at the end parts of the branch pipeline 1 and the branch pipeline 2.
The branch pipelines 8, 9 and 10 are connected with the pipeline 6 through T-shaped tee joints and are provided with pipeline clamps 84, 94 and 104.
The branch pipe 8 is connected with a protein A adsorption column priming solution 83 through an external thread 81 and an internal thread 82.
The branch pipeline 9 is connected with the protein A adsorption column eluent 93 through an external thread 91 and an internal thread 92.
The branch pipeline 8 is connected with the protein A adsorption column equilibrium liquid 103 through an external thread 101 and an internal thread 102.
The branch pipeline 11 is connected with the pipeline 7 through a T-shaped tee joint and is provided with a pipeline clamp 111.
The branch pipe 11 is connected with a waste liquid bag 115 through an internal thread 113 and an external thread 114, and is provided with a rubber sealing sampling port.
The branch pipeline 4 and the branch pipeline 5 are connected with the pipeline 3 through a Y-shaped tee joint and are provided with pipeline clamps 42 and 52, the branch pipeline 4 is provided with an external thread 41, and the end part of the branch pipeline 5 is provided with an internal thread 51.
The utility model has the advantages that: (1) can be simultaneously used for protein A immunoadsorption treatment and whole blood perfusion plus dialysis treatment. (2) The tube does not need to be detached after the whole blood perfuses for two hours, but the blood flowing path is controlled through the tube clamp, the perfusion path is closed, the blood is directly guided into the dialyzer, the following dialysis process is completed, and the infection caused by the contact of the tube and the external environment in the treatment process can be avoided. (3) Separate priming of the dialysis unit, the plasmapheresis unit or the perfusion unit can be achieved. (4) The protein A immunoadsorption column capable of being reused can be eluted and reused on line.
Drawings
Fig. 1 is a schematic view of a closed multifunctional extracorporeal circulation pipeline of the present invention.
Fig. 2 is a schematic structural view of a first embodiment of the sealed multifunctional extracorporeal circulation circuit of the present invention.
Fig. 3 is a schematic structural view of a second embodiment of the closed multifunctional extracorporeal circulation circuit of the present invention.
Detailed Description
The following detailed description of embodiments of the invention. It should be understood that the examples of the present invention are illustrative of the present invention and not restrictive. Modifications made in accordance with the spirit of the invention are within the scope of the invention as claimed.
The first embodiment is as follows:
dialyzer series resin carbon perfusion device treatment:
the dialyzer and the perfusion apparatus are connected to the pipeline in the manner shown in fig. 2, the perfusion apparatus and the dialyzer need to be pre-filled with physiological saline before treatment, the perfusion apparatus 13 is pre-filled first, the pipeline clamps 22, 61, and 111 are opened, the other pipeline clamps are closed, the physiological saline passes through the pipeline 2, enters the perfusion apparatus 13 through the pipeline 6, then enters the pipeline 11 through the pipeline 7, and finally enters the waste liquid bag 115. The dialyzer 14 is then primed, the clamps 22, 31, 32, 42 are opened, the other clamps are closed, and saline passes through line 2, through line 3 and then through line 4 into the hemodialyzer, and the waste fluid is discharged through the venous end of the dialyzer. In the dialysis serial perfusion treatment process, the pipeline clamps 22, 61, 71, 33 and 42 are opened, other pipeline clamps are closed, blood passes through the pipeline 2, enters the pipeline 6 through the upper section of the pipeline 3, then passes through the perfusion device 13, flows out through the pipeline 7, flows back to the lower section of the pipeline 3, finally enters the blood inlet end of the dialyzer 14, and returns to the venous end of the dialysis pipeline through the bleeding end of the perfusion device. After 2h of perfusion, the line clamps 22, 61 and 71 are closed, the connectors 63 and 72 are unscrewed, the perfusion device 13 is taken down, the line clamp 22 is opened again, the line clamps 31 and 32 are opened simultaneously, the line clamps 61 and 71 are still closed, and only the dialysis treatment process is carried out.
Example two:
plasma separation and protein a immunoadsorption column combination therapy:
the plasma separator and the protein A immunoadsorption column are connected to a pipeline according to the mode of figure 3, a dialyzer and the protein A immunoadsorption column need to be pre-filled with physiological saline before treatment, the pipeline clamp 12 is closed firstly, the plasma separator is pre-filled through a dialysis pipeline, then the pipeline clamps 84 and 111 are opened, other pipeline clamps are closed, the pre-filled liquid 83 enters the pipeline 6 through the pipeline 8, enters the protein A immunoadsorption column 13 through the pump pipe 62 under the action of a constant flow pump, flows through the bleeding end through the pipeline 7, and is discharged into the waste liquid bag 115 through the pipeline 11, and whether the filling liquid in the adsorption column is cleaned or not can be monitored by sampling through the sampling port 112. During treatment, the line clamps 12, 61, 71, 33, 52 are opened, the other line clamps are closed, plasma enters the line 1 through the adapter 16, enters the line 6 through the upper section of the line 3, enters the protein a immunoadsorption column 13 through the pump line 62 under the action of the constant flow pump, flows through the line 7 through the bleeding end, returns to the lower section of the line 3, finally enters the line 5, and returns to the venous pot of the dialysis line through the interface 51. After the protein a adsorption column is saturated in adsorption, an elution procedure is performed, the pipeline clamps 94 and 111 are closed, the eluent 93 enters the pipeline 6 through the pipeline 9, enters the protein a immunoadsorption column 13 through the pump 62 under the action of a constant flow pump, flows through the pipeline 7 through a bleeding end, and is finally discharged into the waste liquid bag 115 through the pipeline 11, and whether the antibody in the adsorption column is completely eluted can be monitored by sampling through the sampling port 112. After the elution of the protein A adsorption column is finished, the protein A adsorption column enters a balance program, the pipeline clamps 12, 61 and 71 are still closed, the pipeline clamp 94 is closed, the pipeline clamp 104 is opened, the balance liquid 103 enters the pipeline 6 through the pipeline 10, enters the protein A immunoadsorption column 13 through the pump pipe 62 under the action of a constant flow pump, flows through the pipeline 7 through a bleeding end and is finally discharged into the waste liquid bag 115 through the pipeline 11, and whether the elution liquid in the adsorption column is completely washed or not can be monitored by sampling through the sampling port 112. And completing a treatment cycle after the immunoadsorption column balancing program is completed, and then re-entering the adsorption treatment program, and repeating the cycle.
Claims (10)
1. The utility model provides a multi-functional extrinsic cycle pipeline of closed which characterized in that: the pipeline comprises 3 main pipelines, a pipeline 3, a pipeline 6, a pipeline 7 and 8 branch pipelines, wherein the branch pipelines comprise a branch pipeline 1, a branch pipeline 2, a branch pipeline 4, a branch pipeline 5, a branch pipeline 8, a branch pipeline 9, a branch pipeline 10 and a branch pipeline 11; the branch pipeline 1, the branch pipeline 2 and the pipeline 3 are communicated with each other; the branch pipeline 1 is connected with the adapter of the plasma separator and further connected with the plasma separator, and the branch pipeline 2 is connected with the arterial end of the dialysis pipeline; the end part of the pipeline 6 is connected with the perfusion device, the other end of the pipeline is communicated with the pipeline 3, and a section of pump pipe is designed in the middle of the pipeline 6; the branch pipeline 8, the branch pipeline 9, the branch pipeline 10 and the pipeline 6 are communicated with each other; one end of the pipeline 7 is connected with the perfusion device, the other end of the pipeline is communicated with the pipeline 3, and the branch pipeline 11 is communicated with the pipeline 7; the pipeline 3, the branch pipeline 4 and the branch pipeline 5 are communicated with each other; the branch pipeline 4 is connected with a hemodialyzer; the branch pipeline 5 is connected with the dialysis pipeline venous pot interface; each pipeline is provided with a pipeline clamp, wherein two pipeline clamps are arranged between the pipeline 6 and the pipeline 7 of the pipeline 3; the joints at the end parts of the pipelines are provided with protective caps.
2. The extracorporeal circuit of claim 1, wherein the circuit 3 is connected to the circuit 6 and the circuit 3 is connected to the circuit 7 by a T-junction.
3. The extracorporeal circulation circuit of claim 1, wherein the branch circuit 1 and the branch circuit 2 are connected to the circuit 3 by a Y-shaped tee, and the ends of the branch circuit 1 and the branch circuit 2 are provided with internal threads.
4. The extracorporeal circuit of claim 1, wherein the branch lines 8, 9, 10 are connected to the circuit 6 by a tee.
5. The extracorporeal circuit of claim 1, wherein the branch circuit 8 is externally threaded for connection to a priming solution for a protein a adsorption column.
6. The extracorporeal circuit of claim 1, wherein the branch circuit 9 is externally threaded to connect to the protein a adsorption column eluate.
7. The extracorporeal circuit of claim 1, wherein the branch circuit 8 is externally threaded to connect with a protein a adsorption column equilibration fluid.
8. The extracorporeal circuit of claim 1, wherein the branch circuit 11 is connected to the circuit 7 by a T-junction.
9. The extracorporeal circuit of claim 1, wherein the branch circuit 11 is connected to the waste bag by an internal thread and is provided with a rubber-sealed sampling port.
10. The extracorporeal circulation circuit of claim 1, wherein the branch circuit 4 and the branch circuit 5 are connected to the circuit 3 by a "Y" tee, the branch circuit 4 is provided with external threads, and the end of the branch circuit 5 is provided with internal threads.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921175565.8U CN211096518U (en) | 2019-07-25 | 2019-07-25 | Closed multifunctional extracorporeal circulation pipeline |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921175565.8U CN211096518U (en) | 2019-07-25 | 2019-07-25 | Closed multifunctional extracorporeal circulation pipeline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN211096518U true CN211096518U (en) | 2020-07-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921175565.8U Active CN211096518U (en) | 2019-07-25 | 2019-07-25 | Closed multifunctional extracorporeal circulation pipeline |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN211096518U (en) |
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2019
- 2019-07-25 CN CN201921175565.8U patent/CN211096518U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A closed multifunctional extracorporeal circulation pipeline Effective date of registration: 20231214 Granted publication date: 20200728 Pledgee: Societe Generale Limited by Share Ltd. Chongqing branch Pledgor: CHONGQING XIERKANG BLOOD PURIFICATION EQUIPMENT RESEARCH DEVELOPMENT CO.,LTD. Registration number: Y2023500000103 |