CN102389594A - Portable blood purifying system - Google Patents

Portable blood purifying system Download PDF

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CN102389594A
CN102389594A CN2011102211446A CN201110221144A CN102389594A CN 102389594 A CN102389594 A CN 102389594A CN 2011102211446 A CN2011102211446 A CN 2011102211446A CN 201110221144 A CN201110221144 A CN 201110221144A CN 102389594 A CN102389594 A CN 102389594A
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waste
valve
pressure sensor
end
venous
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CN2011102211446A
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CN102389594B (en
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刘驰
周晓明
裴莹莹
赵刚
高大勇
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黄昱
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Abstract

The invention relates to a portable blood purifying system, which comprises a high throughput dialyzer with an arterial duct, a venous duct, a washing liquid tube and a transfusion tube; the arterial duct is in turn connected in series with an arterial valve, an arterial pressure sensor and a blood pump; the venous duct is in turn connected in series with a venous valve, a venous temperature sensor, a venous bubble detector and a venous pressure sensor, so that an external circulation unit is formed; the washing liquid tube is connected in series with a pre-charging valve and is communicated with a washing liquid container; the transfusion tube is in turn connected in series with a temperature controller, a transfusion tube bubble collector and a transfusion pump, and is communicated with a waste liquid container, so that a waste liquid processing unit is formed; and the system also comprises a transfusion pump, a temperature control device, a transfusion tube, a gating valve and a first transfusion branch and a second transfusion tube branch, so that a transfusion unit is formed. The system is simplified in structure and convenient to carry; and the system is suitable for patients to do short-time dialysis for several times or night dialysis treatment at home as household treatment equipment, so that toxin tolerance of dialysis patients during dialysis period is relieved while medical cost is reduced.

Description

便携式血液净化系统 Portable blood purification system

技术领域 FIELD

[0001] 本发明属于医疗器械技术领域,具体涉及一种用于救治急、慢性肾功能衰竭、多器官衰竭、重度药物和毒物中毒的用于非常规透析的医疗器械,即一种血液净化系统。 [0001] The present invention belongs to the technical field of medical devices, particularly relates to a method for treatment of acute and chronic renal failure, multiple organ failure, severe toxicity for drugs and toxins unconventional dialysis medical device, i.e., a blood purification system .

背景技术 Background technique

[0002] 肾功能衰竭及尿毒症是在世界范围内都非常普遍的危重疾病。 [0002] renal failure and uremia is in the world are very common critical illness. 据美国肾脏数据库显示,在2005年全美有超过45万的晚期肾功能衰竭患者。 According to the American Kidney database shows that in 2005 the United States has more than 450,000 advanced renal failure patients. 在我国,据中华肾脏病学会不完全统计,目前需要治疗的尿毒症患者多达百万以上。 In China, the Chinese Society of Nephrology disease, according to incomplete statistics, uremic patients in need of treatment up to more than one million.

[0003] 目前,肾功能衰竭及尿毒症治疗所应用的主要方法为透析,包括血液透析和腹膜透析。 [0003] Currently, the main method for the treatment of renal failure and uremia applied to dialysis, including hemodialysis and peritoneal dialysis. 血液透析具有清除毒素充分、适于长期应用等优点,是临床上应用最多的治疗方法。 Hemodialysis has fully remove toxins, suitable for long-term use, etc., it is the most widely used in clinical treatment. 血液透析过程中需要应用的关键设备为血液透析机,现代的血液透析机为了实现较好的治疗效果,结构形式都非常复杂。 The key device during hemodialysis needs to be applied to a hemodialysis machine, modern hemodialysis machine in order to achieve better therapeutic effect, the structure is very complicated. 一般地,血液透析主要包括透析液供给装置、自动监护系统及体外血液循环系统等部分。 In general, including hemodialysis dialysate supplying device, and an automatic monitoring system of the extracorporeal blood circulation system, and other parts. 透析液供给装置包括动力系统和控温系统,前者能自动配制电解质含量接近人体的无菌透析液,并提供透析液回路的负压;后者主要维持透析液恒温供给。 Dialysate feeding device comprises a power system and a temperature control system, the former can be formulated automatically electrolyte content close to the body of sterile dialysate, and the dialysate circuit to provide a negative pressure; the latter is supplied to maintain constant the dialysate. 自动监护装置是为了保证透析过程的体外血液循环安全进行而设置的,一般由透析液及血液流率调控系统、透析液浓度监测系统、动静脉压监护系统、漏血监护系统等部分组成。 Automatic monitoring means in order to ensure the safety of an extracorporeal blood circulation and dialysis procedure is provided, it is normally made dialysate and blood flow rate regulation system, the dialysate concentration monitoring system, monitoring system movement pulse pressure, blood leakage monitoring system components.

[0004] 基于复杂的设备结构和工作过程,血液透析机能较有效地去除尿毒症患者体内的毒素。 [0004] Given the complex structure and operation of the devices, hemodialysis function more effectively remove toxins uremic patients. 但目前血液透析机及相应的治疗模式仍具有较大弊端,主要体现在: But the hemodialysis machine and the corresponding treatment modalities still have great drawbacks, mainly reflected in:

1)净化效率低。 1) low purification efficiency. 血液透析机治疗的主要原理是在膜两侧的浓度差驱动下,血液中的毒素渐渐向透析液侧扩散。 The main principle of treatment is hemodialysis machine in driving concentration difference across the membrane, diffusion of toxins from the blood to the dialysate side gradually. 现代透析方法能够高效去除血液中的小分子毒素,但是对尿素症患者体内的关键的中分子毒素的去除效率明显不足。 Modern dialysis method can efficiently remove small molecule toxins in the blood, but the removal efficiency of key molecules in vivo toxin in patients with urea disease is clearly insufficient. 为了达到充分的解毒效果,一般每次透析治疗需要多达120升以上清洗液。 In order to achieve a sufficient effect detoxification, generally each dialysis treatment requires up to 120 liters wash solution.

[0005] 2)治疗成本高。 High [0005] 2) the cost of treatment. 血液透析中的透析液一般在治疗过程中在线配制,因此血液透析机中需要复杂的透析液供给装置,以实现自动配制电解质含量接近人体的无菌透析液。 Hemodialysis dialysate line is generally formulated in the treatment process, thus the complex dialysate supplying device need hemodialysis machine, for automatic preparation of sterile dialysate is close to the body of the electrolyte content. 而且为了保证运行安全,血液透析机中还需要附设浓度监护及误配报警,以预防机器及人为故障造成的误配透析液发生。 And in order to ensure safe operation, the hemodialysis machine also need to monitor the concentration and attached mismatch alarm, to prevent mismatches dialysate caused by machines and human error occurs. 复杂的系统结构造成设备成本高昂。 Complex system architecture resulting in costly equipment. 另一方面,血液透析过程中需要耗费大量的透析液,从而导致设备的使用成本也居高不下。 On the other hand, during hemodialysis requires a large amount of dialysate, resulting in equipment costs are also high. 而且,为了满足透析用水需要,血液透析要求配备复杂的水处理设备,进一步提高了血液透析的治疗成本。 Further, in order to meet the water needs of dialysis, hemodialysis treatment requires complex apparatus with further improved hemodialysis treatment cost. 在美国, 仅2000年一用用于晚期肾功能衰竭治疗的费用就高达142亿美元。 In the US, only in 2000 with a cost for the treatment of advanced renal failure as high as $ 14.2 billion. 而在中国,住院血液透析人均年医疗费用约为6至10万元,高昂的费用造成很多患者得不到有效的治疗而死亡。 In China, inpatient hemodialysis in medical expenses per capita is about 6-100000 yuan, the high costs caused by the lack of effective treatment of many patients died.

[0006] 3)病人生活质量差。 [0006] 3) patients' quality of life is poor. 现有的血液透析机体型庞大,且需要大型水净化系统支持,因此对设备的使用场地提出了很高的要求。 Hemodialysis existing large body type and need large-scale water purification systems support, so the use of space equipment made high demands. 因此,当前的血液透析方式主要还是所谓的透析中心血透(In-center hemodialysis),即病人前往医院透析中心,每周透析2〜3次,每次透析4〜6小时。 Therefore, the current way of hemodialysis dialysis centers mainly so-called hemodialysis (In-center hemodialysis), namely the patient to the hospital dialysis centers, dialysis 2 or 3 times a week for dialysis 4 ~ 6 hours. 这样繁琐的往返治疗会严重干扰患者的日常工作和生活,降低患者的生存质量,长期治疗会容易使病人产生心理障碍。 Such cumbersome and from treatment would seriously interfere with the patient's daily life and work, reduce the quality of life of patients, long-term treatment so that the patient can easily lead to psychological disorders. 据统计,高达27%的血透病人有自杀倾向。 According to statistics, up to 27% of hemodialysis patients with suicidal tendencies. [0007] 基于现有血液透析机所存在的以上问题,本发明致力于应用新的方法和设计以提高治疗质量、降低治疗成本和提高病人生活质量。 [0007] Based on the above problems of the prior existence of a hemodialysis machine, application of the present invention is directed to new methods and designs to improve the quality of treatment, lower the cost of treatment and improve patient quality of life.

发明内容 SUMMARY

[0008] 为了解决现有的血液透析机及相应的治疗模式存在的血液净化效率低、治疗成本高、病人生活质量差的问题,本发明提供一种治疗质量高、治疗成本低和提高病人生活质量的便携式血液净化系统。 [0008] In order to solve the low efficiency of purification of blood present in conventional hemodialysis machine and the appropriate treatment modalities, the high cost of treatment, patients with poor quality of life issues, the present invention provides a method of treating a high quality, low cost, and improve the treatment of life in patients portable blood purification system quality.

[0009] 实现上述目的的技术解决方案如下: [0009] achieving the above object of the technical solution is as follows:

便携式血液净化系统包括高通量透析器4,所述高通量透析器4的内腔入口401连通着动脉导管100的一端,从另一端起动脉导管上依次串联着动脉阀101、动脉压力传感器103 和血泵104 ;高通量透析器4的内腔出口402连通着静脉导管110的一端,从另一端起静脉导管上依次串联着静脉阀109、静脉温度传感器108、静脉气泡检测器107、静脉压力传感器106,构成体外循环单元;所述动脉压力传感器103和静脉压力传感器106上分别设有气泡收集器; Portable blood purification system comprising a high-flux dialyzer 4, the high-flux dialyzer 4 lumen 401 communicates with the inlet end of the arterial catheter 100, the valve 101 in series sequentially from the artery the arterial catheter reach another, an arterial pressure sensor 103 and blood pump 104; a high-flux dialyzer outlet lumen 402 of conduit 110 communicates with one end of the vein, the vein valve 109 are sequentially connected in series, the temperature sensor 108 veins, venous bubble detector 107 from the other reach the venous catheter, venous pressure sensor 106, constituting the extracorporeal unit; bubble trap are provided on the arterial pressure sensor 103 and a venous pressure sensor 106;

所述高通量透析器4的外腔入口403连通着清洗液管的一端,清洗液管的另一端连通着清洗液容器201,清洗液容器201上设有清洗液重量传感器202,清洗液管上串联着预充阀306 ;清洗液容器201的出口连通着输液管200的一端,输液管200的另一端连通着输液选通阀206的第一端口,输液管200上依次串联着温度控制器203、输液管气泡收集器204 和输液泵205 ;输液选通阀206的第二端口连通着第一输液管支路210的一端,第一输液管支路210的另一端通过三通管连通着高通量透析器的内腔出口402和静脉压力传感器106 的进口之间静脉导管110 ;输液选通阀206的第三端口连通着第二输液管支路220的一端, 第二输液管支路220的另一端通过三通管连通着动脉阀101和动脉压力传感器103之间的动脉导管100 ; The high-flux dialyzer outer chamber 4 communicates with the inlet end 403 of the washing liquid pipe, the other end of the cleaning liquid pipe 201 communicates with the cleaning liquid tank, the cleaning fluid container 201 is provided with a weight sensor 202 cleaning liquid, the cleaning liquid pipe the series with the pre-fill valve 306; cleaning solution tank outlet 201 communicated with an end of the infusion tube 200, the other end of the infusion tube 200 in communication with the infusion port of the first gate valve 206, 200 in series with the temperature controller of the infusion tube 203, infusion tube 204 of the bubble trap 205 and the infusion pump; infusion gate valve port 206 communicates with the second end of the first infusion tube leg 210, a first infusion tube branch 210 communicates with the other end through the tee an outlet between the inlet lumen 402 of high flux dialyzer and the venous pressure sensor 106 of the intravenous catheter 110; infusion gate valve port 206 communicates with the third end of the second leg 220 of the infusion tube, the second infusion tube branch the other end of the communication pipe 220 through the tee 100 between the arterial catheter 103 and valve 101 artery arterial pressure sensor;

高通量透析器4的外腔出口404连通着废液管的一端,废液管的另一端连通着废液容器301,废液容器301上设有废液重量传感器302,废液管上串联着漏血探测器305、废液压力传感器304、超滤泵303,废液压力传感器304上设有压力传感器。 High-flux dialyzer outer chamber 404 communicates with outlet 4 end of the waste line, the waste line and the other end communicates with a waste container 301, the waste liquid is provided with a weight sensor 302 on the waste container 301, the waste line in series a blood leak detector 305, effluent pressure sensor 304, the ultrafiltration pump 303, a pressure sensor is provided with a pressure sensor 304 on the waste.

[0010] 所述高通量透析器4的外腔入口403连通着废液选通阀307的第一端口,废液选通阀307的第二端口连通着清洗液容器201,废液选通阀307的第三端口连通着再生管的一端,再生管的另一端连通着废液容器301的出口,从废液容器301出口起的再生管上依次串联着吸附器310、除菌过滤器309、再生泵308。 External cavity [0010] of the high-flux dialyzer 4, an inlet port 403 communicates with the first waste gate valve 307, the waste gate valve in communication with the second port 307 of the cleaning liquid container 201, the waste gate One end of the third port in communication with the regeneration valve 307 of the pipe, the other end communicates with the outlet pipe regeneration waste container 301 from the regeneration waste container 301 from the tube outlet 310 in series with the adsorber, filter sterilization 309 , 308 regeneration pump.

[0011] 所述温度控制器203为电热式加热器。 The [0011] temperature controller 203 is an electric heater.

[0012] 所述动脉压力传感器103、静脉压力传感器106和废液压力传感器304上带有气泡收集器。 [0012] The arterial pressure sensor 103, a pressure sensor with a venous bubble trap 106 and pressure sensor 304 waste.

[0013] 所述血泵104、输液泵205和超滤泵303为蠕动泵,转速精确可调。 [0013] The blood pump 104, the infusion pump and the ultrafiltration pump 205 is a peristaltic pump 303, precisely adjustable speed.

[0014] 所述动脉阀101、静脉阀109及预充阀306为双向夹管阀,输液选通阀206及废液选通阀307为三向夹管阀。 [0014] The valve 101 artery, vein valve 109 and the pre-fill valve 306 is a two-way pinch valves, an infusion valve 206 and the waste gate valve 307 is gated to the three pinch valve.

[0015] 本发明可以实现两种功能:单纯血液滤过和血液透析滤过。 [0015] The present invention may implement two functions: pure hemofiltration and hemodiafiltration. 当本发明实现血液透析滤过功能时,输液单元包括瓶装或袋装无菌清洗液、输液泵、输液管、选通阀等元件,其中输液管经选通阀分别与体外血液循环系统的动脉导管和静脉导管相连通,通过设备选通阀 When the present invention is to achieve functional hemodiafiltration, bottled or bagged infusion unit comprising a sterile washing solution, infusion pump, infusion tube, a gate valve or the like element, wherein the infusion tube through a gate valve, respectively, the arterial extracorporeal blood circulation system catheters and catheter in communication, through a gate valve apparatus

4状态可灵活选择前稀释(“先灌注后超滤”)或后稀释(“先灌注后超滤”);废液处理单元包括超滤泵、废液管、清洗液再生装置和废液容器等元件,废液在泵的驱动下在吸附器被吸附净化,进入高通量透析器或滤过器以透析的作用持续清除血液中的毒素。 4 the flexibility to choose the state before diluted ( "first infusion ultrafiltration") or a diluted ( 'after the first infusion ultrafiltration "); waste treatment unit comprises an ultrafiltration pump, a waste tube, the cleaning liquid reproducing apparatus and a waste container and other elements, driving the pump at the waste is adsorbed in the adsorber purge, into a high-flux dialyzer or filter to remove blood dialysis duration of action of the toxin. 当本发明实现单纯血液滤过功能时,超滤液直接形成废液收集在废液容器里。 When the present invention is implemented purely hemofiltration functions, direct the ultrafiltrate collected in the waste liquid is formed in the waste container.

[0016] 在两种工作模式下,本发明均采用了如下一种非侵入性测量和控制流速的方法: 通过读取重量传感器所测得的清洗液和废液的重量变化,反馈控制清洗液和废液流速,并间接地控制净超滤量。 [0016] In both modes of the present invention are used as a non-invasive method of measuring and controlling the flow rate: by reading the weight sensors measured the weight change of the cleaning liquid and waste, feedback control washing liquid and waste flow rate, and the net ultrafiltration volume is indirectly controlled.

[0017] 在输液单元,本发明的温度控制器为一种电热式加热器,以实现非浸入式的清洗液加热。 [0017] The infusion unit, the temperature controller of the present invention is an electric heater, in order to achieve a non-immersion cleaning liquid is heated. 在温度控制器内部,清洗液流经一个特殊形状的液袋,且在该液袋中回形流动,流动过程中被硅胶加温恒温器逐渐加热。 Internal temperature controller, a cleaning liquid through the fluid bags specially shaped and meander-shaped flow of the liquid in the bag, the flow process silica is warmed gradually heated thermostat.

[0018] 系统中的清洗液再生机构包括含有活性炭、树脂等吸附剂的吸附器310、再生泵308和除菌过滤器309。 [0018] The cleaning liquid reproducing mechanism system comprises an adsorbent comprising activated carbon, adsorption resin or the like 310, 308 regeneration pump 309 and filter sterilization. 来自清洗废液在再生泵308的驱动下进入吸附器310被吸附净化, 成为再生透析液重新进入高通量透析器,以透析的作用持续清除血液中的小分子毒素。 The spent cleaning liquid from entering the adsorber in the regeneration of the driving of the pump 308 is an adsorption clarifier 310, it becomes regenerated dialysate re-entering the high flux dialyzer dialysis to remove small molecule toxins duration of action in blood.

[0019] 通过以上设计,本发明相对血液透析机具有以下几方面的优点: 1)具有高效的中、小分子毒素清除能力,血液净化效率明显提高。 [0019] By the above design, the present invention relative to a hemodialysis machine has the following advantages: 1) in a highly efficient, small molecule toxins scavenging ability, the blood purification efficiency is significantly improved.

[0020] 2)治疗所需清洗液大大减少,每次治疗只需要小于8升的清洗液,一方面使得系统摆脱了对水净化设备的依赖,治疗成本也大大降低。 [0020] 2) treatment of the cleaning liquid required is greatly reduced, only less than 8 per treatment liters of cleaning solution, on the one hand to make the system out of the water purification device dependent, treatment costs are reduced.

[0021] 3)系统运行所用清洗液可预先配制,无需复杂的透析液在线配制系统及相应的浓度监控等系统,设备结构大大简化,运行可靠性和安全性也相对提高。 Cleaning solution [0021] 3) operation of the system may be pre-formulated with, without the complexity of a dialysate preparation system and the corresponding line concentration monitoring system, greatly simplifying the device configuration, operation reliability and safety is also enhanced.

[0022] 4)系统运行过程简单,无需复杂的专业操作,病人可以自主进行治疗。 [0022] 4) operation of the system is simple, without complex professional operation, the patient can be treated autonomously. 系统中的智能控制系统能够将病人的生理数据远程传输到透析监测中心,从而有效地保障治疗安全和治疗疗效。 Intelligent Control System system is able to transfer the patient's physiological data to a remote monitoring center dialysis, so as to effectively guarantee the safety and therapeutic efficacy of treatment.

[0023] 5)相对传统血液透析机,本发明结构大大简化,可以方便地移动,且便于携带。 [0023] 5) relative to a conventional hemodialysis machine, greatly simplify the structure of the present invention, it can be easily moved, and portable. 本发明可以作为居家治疗设备,更适合患者在家里多次短时透析或夜间透析治疗,在降低医护成本的同时降低透析病人在透析间期的毒素耐受。 The present invention can be used as home treatment device, more suitable for patients with multiple short dialysis or nocturnal dialysis treatment at home, reducing dialysis patients endotoxin tolerance in between dialysis while reducing health care costs.

附图说明 BRIEF DESCRIPTION

[0024] 图1为本发明结构示意图。 [0024] Fig 1 a schematic view of the structure of the present invention.

[0025] 图2为具有清洗液再生模块的结构示意图。 [0025] FIG. 2 is a schematic structural diagram of a cleaning liquid having a regeneration module.

[0026] 上述图中,100动脉导管、101动脉阀、102三通管、103动脉压力传感器、104血泵、 105三通管、106静脉压力传感器、107静脉气泡检测器、108静脉温度传感器、109动脉阀、 110静脉导管、200输液管、201清洗液容器、202清洗液重量传感器、203温度控制装置、204 输液管气泡收集器、205输液泵、206输液管选通阀、210输液管支路、220输液管支路、301废液容器、302废液重量传感器、303超滤泵、304废液压力传感器及压力传感器、305漏血探测器、306预充阀、307废液管选通阀、4高通量透析器、401高通量透析器的内腔入口、402高通量透析器的外腔出口、403高通量透析器的外腔入口、404高通量透析器的外腔出口。 [0026] FIG above, the arterial catheter 100, the valve 101 artery, tee 102, an arterial pressure sensor 103, blood pump 104, tee 105, 106 venous pressure sensor, venous bubble detector 107, temperature sensor 108 vein, 109 artery valve, 110 intravenous catheter, 200 infusion tube, 201 cleaning liquid container 202 cleaning liquid weight sensor, 203 a temperature control device 204 infusion tube bubble trap 205 infusion pump 206 infusion tube gating valve 210 infusion tube support Road branch infusion tube 220, waste container 301, the waste liquid weight sensor 302, the ultrafiltration pump 303, the waste liquid pressure sensor 304 and the pressure sensor, blood leak detector 305, pre-fill valve 306, gate 307 waste line valves, high-flux dialyzer 4, the inlet lumen 401 of high flux dialyzer outer chamber outlet 402 high flux dialyzer outer chamber inlet 403 of high-flux dialyzer, high-flux dialyzer 404 outer chamber outlet.

具体实施方式 detailed description

[0027] 下面结合附图,通过实施例对本发明作进一步地描述。 [0027] below with the accompanying drawings, by way of example will be further described in the present invention.

5[0028] 实施例: 5 [0028] Example:

参见图1,便携式血液净化系统包括高通量透析器4,高通量透析器4的内腔入口401 连通着动脉导管100的一端,从另一端起动脉导管上依次串联着动脉阀101、动脉压力传感器103和血泵104 ;高通量透析器4的内腔出口402连通着静脉导管110的一端,从另一端起静脉导管上依次串联着静脉阀109、静脉温度传感器108、静脉气泡检测器107、静脉压力传感器106,构成体外循环单元;动脉压力传感器103和静脉压力传感器106上分别安装有气泡收集器; Referring to Figure 1, a portable blood purification system comprising a high-flux dialyzer 4, 4 high-flux dialyzer inlet lumen 401 communicates with one end of the arterial catheter 100, the valve 101 in series sequentially from the artery the arterial catheter reach another, arterial the pressure sensor 103 and blood pump 104; a high-flux dialyzer outlet lumen 402 of conduit 110 communicates with one end of the vein, the vein valve 109 are sequentially connected in series, the temperature sensor 108 veins, venous bubble detector from the other terminus vein catheter 107, venous pressure sensor 106, constituting the extracorporeal unit; are mounted on the bubble trap 103 and an arterial pressure sensor venous pressure sensor 106;

高通量透析器4的外腔入口403连通着清洗液管的一端,清洗液管的另一端连通着清洗液容器201,清洗液容器201上安装有清洗液重量传感器202,清洗液管上串联着预充阀306 ;清洗液容器201的出口连通着输液管200的一端,输液管200的另一端连通着输液选通阀206的第一端口,输液管200上依次串联着温度控制器203、输液管气泡收集器204和输液泵205 ;输液选通阀206的第二端口连通着第一输液管支路210的一端,第一输液管支路210的另一端通过三通管连通着高通量透析器的内腔出口402和静脉压力传感器106的进口之间静脉导管110 ;输液选通阀206的第三端口连通着第二输液管支路220的一端,第二输液管支路220的另一端通过三通管连通着动脉阀101和动脉压力传感器103之间的动脉导管100 ; High-flux dialyzer outer chamber 4 communicates with the inlet end 403 of tube cleaning liquid, the washing liquid pipe and the other end in communication with the cleaning liquid container 201, cleaning liquid weight sensor 201 is mounted to the liquid container 202, the washing liquid pipe on the series the pre-fill valve 306; cleaning solution tank outlet 201 communicated with an end of the infusion tube 200, the other end of the infusion tube 200 in communication with the infusion port of the first gate valve 206, 200 in series with the temperature controller 203 infusion tube, infusion tube bubble trap 204 and the infusion pump 205; a second port 206 communicating with the end of the first leg 210 of the infusion tube, the other end of the first infusion tube of an infusion branch gate valve 210 communicates through a high-pass tee between the amount of the dialyzer outlet lumen 402 and venous inlet pressure sensor 106 intravenous catheter 110; infusion gate valve port 206 communicates with the third end of the second leg 220 of the infusion tube, the second branch 220 of the infusion tube the other end is communicated with a tee 101 and valve artery arterial pressure sensor 103 between the arterial catheter 100;

高通量透析器4的外腔出口404连通着废液管的一端,废液管的另一端连通着废液容器301,废液容器301上安装有废液重量传感器302,废液管上串联着漏血探测器305、废液压力传感器304、超滤泵303,废液压力传感器304上安装有气泡收集器。 High-flux dialyzer outer chamber 404 communicates with outlet 4 at one end of the waste tube, the other end of the waste line 301 communicates with a waste container, liquid waste with a weight sensor 302 is mounted on the waste container 301, the waste line in series a blood leak detector 305, effluent pressure sensor 304, the ultrafiltration pump 303, is mounted on the bubble trap effluent pressure sensor 304.

[0029] 参见图2,高通量透析器4的外腔入口403连通着废液选通阀307的第一端口,废液选通阀307的第二端口连通着清洗液容器201,废液选通阀307的第三端口连通着再生管的一端,再生管的另一端连通着废液容器301的出口,从废液容器301出口起的再生管上依次串联着吸附器310、除菌过滤器309、再生泵308 ;这一部份机构形成清洗液再生机构。 [0029] Referring to Figure 2, a high-flux dialyzer outer chamber 403 communicates with the inlet 4 of the waste gate valve of the first port 307, the waste gate valve in communication with the second port 307 of the cleaning liquid container 201, waste gating end of the valve tube in communication with the third port 307 regeneration, the regeneration and the other end communicates with the outlet pipe of the waste container 301, the tube starting from the regeneration of the waste container 301 in series with the outlet of the adsorber 310, filter sterilization 309, 308 regeneration pump; this part of the cleaning liquid reproducing means forming mechanism.

[0030] 高通量透析器4型号为日本旭化成医疗器械株式会社的APS系列旭化成聚砜膜血液透析器。 [0030] High flux dialyzer type 4 polysulfone membrane into a hemodialyzer is medical equipment Asahi Kasei Corporation Asahi APS series.

[0031] 温度控制器203为电热式加热器,产品型号:ANIMEC AM-2S Fluid Warmer(美国)。 [0031] The temperature controller 203 is an electric heater, Model: ANIMEC AM-2S Fluid Warmer (USA).

[0032] 动脉压力传感器103、静脉压力传感器106和废液压力传感器304中包括气泡收集器,传感器硬件通过空气测量压力值,而不与液体直接接触。 [0032] an arterial pressure sensor 103, pressure sensor 106 and a venous pressure sensor 304 comprises a waste liquid bubble trap, a sensor measuring the air pressure by the hardware, without direct contact with the liquid.

[0033] 血泵104、输液泵205和超滤泵303皆为蠕动泵,泵体不与管内流体直接接触。 [0033] Blood pump 104, the infusion pump 205 and the pump 303 are all ultrafiltration peristaltic pump, the pump is not in direct contact with the fluid inside.

[0034] 动脉阀101、静脉阀109及预充阀306为双向夹管阀,输液选通阀206及废液选通阀307为三向夹管阀。 [0034] artery valve 101, valve 109, and intravenous pre-fill valve 306 is a two-way pinch valves, an infusion valve 206 and the waste gate valve 307 is gated to the three pinch valve.

[0035] 单纯血液滤过工作模式如下: [0035] simple blood filtration mode of operation as follows:

如图1所示,系统的动脉导管100与静脉导管110分别连接到人体的动脉与静脉。 1, the arterial catheter system 100 are connected to arteries and veins of the human body 110 and the venous catheter. 在体外血液循环单元1中,动脉血液经动脉阀101、三通管102和动脉压力传感器103,被血泵104泵入高通量透析器4的内腔入口401。 In the extracorporeal blood circulation unit 1, the arterial blood arterial valve 101, tees 102 and the arterial pressure sensor 103, blood pump 104 is pumped into the high-flux dialyzer inlet lumen 401 4. 血液由高通量透析器4的内腔出口402流出, 经静脉三通管105、静脉压力传感器106、静脉气泡检测器107、温度传感器108、静脉阀109, 由静脉导管110流回人体。 High-flux dialyzer blood from the lumen 402 flows out of the outlet 4, intravenous tee 105, venous pressure sensor 106, a venous bubble detector 107, temperature sensor 108, vein valve 109, conduit 110 back into the body intravenously.

[0036] 在输液单元中,无菌透析液从清洗液容器201由输液管200流经温度控制器203、 输液管压力传感器204,由输液泵205泵入体外血液循环。 [0036] The infusion unit, the sterilized dialysis fluid from the cleaning liquid container 201 by the infusion tube 200 flows through a temperature controller 203, the infusion tube pressure sensor 204, infusion pump 205 is pumped into the extracorporeal blood circulation. 清洗液的注入点有两种选择。 Cleaning liquid injection point there are two choices. its

6中,清洗液注入动脉导管100中与血液混合,称为前稀释即“先稀释后超滤”;而清洗液注入静脉导管110中与血液混合,称为后稀释即“先超滤后稀释”。 6, the cleaning liquid injection catheter 100 with the arterial blood mixing, i.e. before dilution called "diluted before ultrafiltration"; the cleaning liquid into the vein conduit 110 is mixed with the blood, i.e. "diluted before ultrafiltration diluted called . "

[0037] 在废液处理单元中,超滤液在超滤泵305的驱动下从高通量透析器的外腔出口404流出形成废液,废液依次流经漏血探测器305、废液压力传感器304流回废液容器301。 [0037] In the waste treatment unit, the ultrafiltrate 404 is formed from the waste flow out of the outlet chamber of the high-flux dialyzer pump 305 driven by the ultrafiltration of waste sequentially through blood leak detector 305, the waste pressure sensor 304 back into the waste container 301. 其中,废液压力传感器304用于跨膜压力的检测。 Wherein the waste liquid pressure sensor 304 for detecting the transmembrane pressure.

[0038] 清洗液容器201和废液容器301中液体的重量分别由清洗液重量传感器202和废液重量传感器302测量,以反馈控制清洗液和废液的流速,并间接精确控制灌注和超滤的速率。 [0038] by weight of the cleaning liquid container 201 and waste fluid container 301 respectively, by weight of the cleaning liquid sensor 202 and the sensor 302 measures the weight of the waste liquid, the cleaning liquid and the feedback control of the waste flow rate, and indirectly control the precise infusion and ultrafiltration s speed.

[0039] 血液透析滤过工作模式如下: [0039] hemodiafiltration operating mode is as follows:

在此工作模式下,系统的体外血液循环单元和输液单元与单纯血液滤过模式下相同。 In this mode of operation, the same unit and the extracorporeal blood circulation with a simple infusion unit hemofiltration mode of the system. 所不同在于,废液处理单元中增加了吸附器310及再生泵308等元件,如图2所示。 The difference is that, in the waste treatment unit 310 increases the adsorption and regeneration of the pump element 308 and the like, as shown in FIG. 从高通量透析器的外腔出口404流出的废液进入废液容器301后,在再生泵308的驱动下入吸附器310,废液再生为透析液,然后经过除菌过滤器309自高通量透析器和高通量透析器4的外腔入口403重新进入高通量透析器4。 After the waste container into the outer chamber 301 from the waste outlet of the high-flux dialyzer 404 flowing out of the pump 308 into the reproduction drive 310 adsorption, regeneration of the dialysate effluent and then through sterilizing filter 309 from high high-flux dialyzer and the outer flux dialyzer inlet chamber 4 into the high-flux dialyzer 403 back 4. 在吸附器310中废液中含有的大部分毒素被吸附剂吸附,经处理后的再生透析液中毒素含量远低于血液,因此在高通量透析器4内血液侧的毒素尤其是能够持续扩散至透析液侧。 Most toxins contained in the waste liquid 310 is adsorbed by the adsorbent in the adsorber, the regenerated dialysate after endotoxin treatment is much lower than the blood, so the blood side of toxins in the high-flux dialyzer 4 in particular can continue diffused into the dialysate side. 此外,通过控制再生泵310和超滤泵303使得废液流速大于再生透析液流速,即可实现连续的超滤作用,系统通过透析滤过的方式持续清除血液内的毒素。 Further, by controlling the pump 310 and the reproducing so that the ultrafiltration pump 303 is greater than the flow rate of the regeneration effluent dialysate flow rate, to achieve a continuous ultrafiltration system continuously by way of diafiltration to remove toxins in the blood.

7 7

Claims (6)

1.便携式血液净化系统,包括高通量透析器(4),其特征在于,所述高通量透析器(4) 的内腔入口(401)连通着动脉导管(100)的一端,从另一端起动脉导管上依次串联着动脉阀(101)、动脉压力传感器(103)和血泵(104);高通量透析器(4)的内腔出口(402)连通着静脉导管(110)的一端,从另一端起静脉导管上依次串联着静脉阀(109)、静脉温度传感器(108)、静脉气泡检测器(107)、静脉压力传感器(106),构成体外循环单元;所述动脉压力传感器(103)和静脉压力传感器(106)上分别设有气泡收集器;所述高通量透析器(4)的外腔入口(403)连通着清洗液管的一端,清洗液管的另一端连通着清洗液容器(201 ),清洗液容器(201)上设有清洗液重量传感器(202),清洗液管上串联着预充阀(306);清洗液容器(201)的出口连通着输液管(200)的一端,输液管(200) 的另一端连 1 portable blood purification system comprising a high-flux dialyzer (4), characterized in that said high-flux dialyzer inlet lumen (4) (401) communicates with one end of the arterial catheter (100) from the other one end of the arterial catheter in series artery valve (101), arterial pressure sensor (103) and a blood pump (104); high-flux dialyzer (4) an outlet lumen (402) communicates with an intravenous catheter (110) end, from the other terminus in series with the venous catheter venous valve (109), venous temperature sensor (108), a venous bubble detector (107), venous pressure sensor (106), constituting the extracorporeal unit; the arterial pressure sensor (103) and a venous pressure sensor (106) are provided on the bubble trap; outer chamber inlet of the high flux dialyzer (4) (403) communicates with one end of the washing liquid pipe, the other end of the cleaning liquid communication pipe the cleaning liquid container (201), the cleaning liquid container is provided with a cleaning liquid weight sensor (202) (201), the pre-fill valve cleaning series (306) on the liquid pipe; cleaning fluid container (201) communicates with the outlet of the infusion tube One end of the other end (200) of the infusion tube (200) connected 着输液选通阀(206)的第一端口,输液管(200)上依次串联着温度控制器(203)、输液管气泡收集器(204)和输液泵(205);输液选通阀(206)的第二端口连通着第一输液管支路(210)的一端,第一输液管支路(210)的另一端通过三通管连通着高通量透析器的内腔出口(402)和静脉压力传感器(106)的进口之间静脉导管(110);输液选通阀(206 )的第三端口连通着第二输液管支路(220 )的一端,第二输液管支路(220 )的另一端通过三通管连通着动脉阀(101)和动脉压力传感器(103)之间的动脉导管(100);高通量透析器(4)的外腔出口(404)连通着废液管的一端,废液管的另一端连通着废液容器(301),废液容器(301)上设有废液重量传感器(302),废液管上串联着漏血探测器(305)、废液压力传感器(304)、超滤泵(303),废液压力传感器(304)上设有压力传感器。 Infusion on the gate valve (206) to the first port, the infusion tube (200) in series with the temperature controller (203), the infusion tube bubble trap (204) and an infusion pump (205); infusion gate valve (206 ) a second port in fluid communication with the first infusion tube branch (210) at one end, the other end of the first infusion tube branch (210) in communication with the outlet lumen of the high flux dialyzer (402) through the tee and venous pressure sensor (106) intravenous catheter (110) between the inlet; third infusion port gate valve (206) communicates with the second end of the infusion tube branch (220), a second infusion tube branch (220) the other end communicates with the valve through a tee artery arterial catheter (100) between (101) and the arterial pressure sensor (103); high-flux dialyzer (4) an outer chamber outlet (404) communicated with the waste line one end, the other end of the waste tube communicates with a waste container (301), the waste container (301) is provided with a waste liquid weight sensor (302), the blood leak detector with a series (305) on the waste line, the waste hydraulic pressure sensor (304), the ultrafiltration pump (303), the waste pressure sensor provided with a pressure sensor (304).
2.根据权利要求1所述的便携式血液净化系统,其特征在于:所述高通量透析器(4) 的外腔入口(403)连通着废液选通阀(307)的第一端口,废液选通阀(307)的第二端口连通着清洗液容器(201),废液选通阀(307)的第三端口连通着再生管的一端,再生管的另一端连通着废液容器(301)的出口,从废液容器(301)出口起的再生管上依次串联着吸附器(310)、除菌过滤器(309)、再生泵(308)。 The portable blood purification system according to claim 1, wherein: an outer chamber inlet of the high flux dialyzer (4) (403) communicated with the waste gate valve (307) to the first port, waste gate valve (307) communicates with the second port of the cleaning liquid container (201), the waste gate valve (307) communicates with the third port of the regeneration tube end, the other end of the tube communicating with the regeneration waste container (301) outlet, the tube starting from the regeneration of the waste container (301) in series with the adsorber outlet (310), sterilizing filter (309), the regeneration of the pump (308).
3.根据权利要求1所述的便携式血液净化系统,其特征在于:所述温度控制器(203)为电热式加热器。 3. The portable blood purification system according to claim 1, wherein: said temperature controller (203) is an electric heater.
4.根据权利要求1所述的便携式血液净化系统,其特征在于:所述动脉压力传感器(103)、静脉压力传感器(106)和废液压力传感器(304)上带有气泡收集器。 4. The portable blood purification system according to claim 1, wherein: the arterial pressure sensor (103), with the bubble trap venous pressure sensor (106) and the waste pressure sensor (304).
5.根据权利要求1所述的便携式血液净化系统,其特征在于:所述血泵(104)、输液泵(205)和超滤泵(303)为蠕动泵。 The portable blood purification system according to claim 1, wherein: the blood pump (104), the infusion pump (205) and the ultrafiltration pump (303) is a peristaltic pump.
6.根据权利要求1所述的便携式血液净化系统,其特征在于:所述动脉阀(101)、静脉阀(109)及预充阀(306)为双向夹管阀,输液选通阀(206)及废液选通阀(307)为三向夹管阀。 The portable blood purification system according to claim 1, wherein: said artery valve (101), venous valve (109) and the pre-fill valve (306) is a two-way pinch valves, an infusion valve gate (206 ) and waste gate valve (307) is a three-way pinch valve.
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CN101678161A (en) * 2007-04-12 2010-03-24 甘布罗伦迪亚股份公司 Method and apparatus for priming an extracorporeal blood circuit
WO2010042666A2 (en) * 2008-10-07 2010-04-15 Xcorporeal, Inc. Priming system and method for dialysis systems
CN101708347A (en) * 2009-03-11 2010-05-19 重庆多泰医用设备有限公司 Hemodialysis system for controlling electric conduction and ultra-filtration by weighing
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CN105377322B (en) * 2013-04-16 2018-03-23 费森尤斯医疗保健公司 The method for determining the pressure in extracorporal circulatory system
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