CN211022696U - Portable noninvasive blood glucose detection device based on near-infrared optics - Google Patents

Abstract

The utility model relates to a portable noninvasive blood glucose detecting device based on near infrared optics, which comprises a blood glucose collecting device and an upper computer, wherein the blood glucose collecting device comprises a shell, a power module, a signal collecting module, a signal conditioning module and a signal collecting and transmitting module are integrated in the shell, the power module supplies power for the signal collecting module and the signal conditioning module, the signal conditioning module is connected with the signal collecting and transmitting module, the shell is provided with a collecting port for earlobe, the signal acquisition and transmission module controls the signal conditioning module and converts the voltage signal output by the signal conditioning module into a binary digital signal, and the binary digital signal is transmitted to an upper computer through serial port communication and processed by software to obtain a blood glucose concentration result; the utility model discloses measuring speed is fast, pollution-free, noninvasive.

Description

Portable noninvasive blood glucose detection device based on near-infrared optics

Technical Field

The utility model relates to a blood glucose monitoring equipment field specifically is a portable blood glucose detection device of not creating based on near-infrared optics.

Background

Diabetes is one of four major diseases that endanger human health, and currently, about 10% of adults all over the world suffer from the diabetes. In China, about 4000 million diabetics have an increasing trend of morbidity, and the diabetes brings much inconvenience and pain to the diabetics, seriously affects the quality of life of the diabetics, and imposes heavy burden on the nation and the society. Therefore, it is important to detect the blood sugar level quickly and accurately, monitor the blood sugar level of the human body in real time, and prevent diabetes in advance. At present, no method for completely curing diabetes is found. Clinically, medication is guided primarily by frequent monitoring of blood glucose concentration. The blood sugar detection method widely adopted at present is a minimally invasive blood sugar detection method, which needs to collect blood at the tail end of a finger, brings pain to patients, and has the risk of infection to wounds, so that the frequency of measuring blood sugar is limited, and diabetics cannot realize the expected blood sugar monitoring.

The near infrared spectrum noninvasive blood sugar detection technology has the advantages of convenience in use, high analysis speed, high efficiency, high sensitivity, lower cost, no damage to samples, no consumption of chemical reagents, no pollution to the environment and the like, and is considered to be one of the noninvasive blood sugar detection technologies with the most application prospects. Near infrared light easily penetrates through the body surface, and the penetrability of tissues is good, so that abundant and strong absorption information about the concentration of glucose in blood is obtained deeply, and nondestructive and non-invasive real-time analysis in vivo is carried out. With the continuous and deep research on the near infrared spectrum, the near infrared spectrum is expected to play more practical roles in the diagnosis and real-time measurement of diabetes, realize the accurate control of blood sugar and help diabetic patients to maintain the blood sugar within a healthy and safe threshold.

In 1995, Hiroki et al, Germany, measured the spectrum of a human finger by Fourier transform infrared spectroscopy using attenuated total reflection, and experimental results showed that the method can effectively detect blood glucose concentration information. In 2002, Huanglan, Qinghua university and the like adopt a near-infrared diffuse reflection spectrum technology to perform non-invasive blood glucose detection, and establish a blood glucose correction model by adopting a partial least squares regression method. In 2010, Shanghai university Lidao Fei et al utilize wavelet analysis to perform denoising pretreatment on near infrared spectrum, and establish a blood glucose concentration prediction model by an interval partial least square method. Theoretically, the feasibility of the near infrared spectroscopy applied to noninvasive blood glucose detection is proved, but most of the obtained blood glucose correction models in the current practical products can not meet the clinical requirements. In 2018, Wangzhuh, Beijing post and telecommunications university, in the book of great graduate, "research on noninvasive blood glucose near infrared spectrum signal detection and processing technology", a noninvasive blood glucose detection experimental system was set up, finger skin related data was collected, a blood glucose correction model was established, and the performance of the model was evaluated. However, in the experimental measurement process, the system is easily interfered by noise due to the adoption of a reflected light sensing mode. In addition, the finger skin is thick, infrared light is difficult to permeate into capillary vessels, the intensity of signals acquired by an experimental system is low, and certain errors exist.

Disclosure of Invention

The utility model aims at providing a portable no blood sugar detection device of creating based on near-infrared optics in order to realize accurately not having the wound detection blood sugar.

The utility model has the following concrete scheme: the utility model provides a portable noninvasive blood glucose detection device based on near-infrared optics, includes blood glucose collection system and host computer, and blood glucose collection system includes the shell, and the integration has power module, signal acquisition module, signal conditioning module and signal acquisition transmission module in the shell, and power module gives signal acquisition module and signal conditioning module power supply, and signal conditioning module is connected with signal acquisition transmission module, and the shell is equipped with the collection mouth that is used for the earlobe, signal acquisition module includes near-infrared emission module and the receiving module who receives the earlobe transmission light, and near-infrared emission module and receiving module set up respectively in collection mouth both sides, and receiving module converts received light signal into voltage signal and transmits signal conditioning module, and signal conditioning module amplifies the voltage value of higher level's transmission, filters and change polarity and handles, signal acquisition transmission module controls signal conditioning module and converts the voltage signal of signal conditioning module output into binary And (4) controlling digital signals, transmitting the signals to an upper computer through serial port communication by a signal acquisition and transmission module, and processing the signals by software to obtain a blood glucose concentration result.

Near infrared emission module adopts the wavelength to pass through high frequency modulation for 1640~1660 nm's L ED, receiving module adopts photodiode.

The signal conditioning module adopts the high-speed operational amplifier OPA820 chip of Texas instruments company.

The signal acquisition and transmission module comprises an MSP430f449 chip of Texas instruments.

The working principle of the utility model is as follows: when light passes through human tissue, it is absorbed by the tissue and is accompanied by physical phenomena such as reflection, refraction, scattering, etc. The blood sugar measurement is realized by utilizing the near infrared optical transmission principle. Near infrared light is electromagnetic waves having a wavelength of 780nm to 2500 nm, and penetrates biological tissues to a depth of several millimeters and reaches a tissue site containing blood. The thickness of the near infrared light measurement part has great influence on the measurement result, if the thickness of the skin of the measurement part is too thin, the near infrared light is rarely contacted with the skin, and therefore, the received light has insufficient blood sugar information; if the skin thickness at the measurement site is too thick, the received light intensity will be too small to meet the power requirements for spectral analysis. And if there is more fat in the measurement site, this results in a low signal to noise ratio of the detected signal. The glucose absorption peak value of the ear lobe skin is just in the wavelength range of near infrared light, so that the near infrared light with a certain wavelength is adopted to transmit the ear lobe skin, the transmitted light with different light intensities is obtained after being absorbed by tissues in the tip of the ear lobe, and the transmitted light is converted into an electric signal through a photoelectric receiving tube, so that the pulse wave carrying the blood glucose signal can be obtained. The near infrared light of the invention has the thinnest epidermal layer through the ear lobe part, and is more suitable for near infrared spectrum noninvasive measurement.

The utility model has the advantages of 1, improved measurement accuracy, test error is little, compare with traditional blood sugar detection technology of wicresoft, it is fast to have the measuring speed, pollution-free, advantages such as noninvasive and continuous multiple measurement, 2, select 1650 nm's infrared L ED light source, 1650nm is the sensitive wavelength of blood sugar, compare with other wavelengths, blood sugar has very strong absorption peak value here, avoided the absorption peak of water in the blood at 1440 nm-1460 nm simultaneously again, the influence of moisture in the blood to the measuring result has been reduced well, 3, the characteristics of Texas instrument company MSP430f449 chip low-voltage, low-power consumption and high analog-to-digital conversion precision, select it to be the master control processing chip, accomplish to the voltage signal AD collection and the control of carrying blood sugar information to fortune put chip OPA820, the integrated level is high, easy and host computer software integration.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a flow chart of the detection of the present invention;

FIG. 3 is a diagram of the detection result of the embodiment of the present invention;

in the figure: the system comprises a shell 1, a power supply module 2, a signal conditioning module 3, a signal acquisition and transmission module 4, a near infrared light emitting module 5, a receiving module 6, an earlobe 7 and an upper computer 8.

Detailed Description

Referring to fig. 1, the embodiment includes a blood sugar collecting device and an upper computer 8, the blood sugar collecting device includes a housing 1, a power module 2, a signal collecting module, a signal conditioning module 3 and a signal collecting and transmitting module 4 are integrated in the housing 1, the power module 2 provides a constant ± 5V voltage for the signal collecting module and provides a constant ± 12V voltage for the signal conditioning module 3, the signal conditioning module 3 is connected with the signal collecting and transmitting module 4, the housing 1 is provided with a collecting port for an earlobe 7, the signal collecting module includes a near infrared light emitting module 5 and a receiving module 6 for receiving the transmission light of the earlobe, the near infrared light emitting module 5 and the receiving module 6 are respectively arranged at two sides of the collecting port, the receiving module 6 converts the received light signal into a voltage signal and transmits the voltage signal to the signal conditioning module 3, the signal conditioning module 3 amplifies the voltage value transmitted by a higher level, Filtering and polarity changing processing, the signal acquisition and transmission module 4 controls the signal conditioning module 3 and converts the voltage signal output by the signal conditioning module 3 into a binary digital signal, the signal acquisition and transmission module 4 transmits the binary digital signal to the upper computer 8 through serial port communication, and the upper computer 8 obtains a blood glucose concentration result through software processing.

In this embodiment, the near-infrared light emitting module 5 employs L ED with a wavelength of 1650nm for high frequency modulation, and the receiving module 6 employs a photodiode.

In this embodiment, the signal conditioning module 3 employs a high-speed operational amplifier OPA820 chip of texas instruments company, the output voltage value of the receiving module 6 is a weak signal, and the weak signal is amplified by a certain multiple through the amplifier, so that subsequent signal acquisition is facilitated, the signal carries a large amount of high-frequency noise and a large amount of pulse noise, and needs to be filtered to extract a clean and useful signal, the obtained voltage signal is bipolar, and the subsequent signal acquisition and transmission module 4 is unipolar for unipolar acquisition, so that unipolar processing is performed on the voltage signal, and a dc offset is added.

The signal acquisition and transmission module 4 of the present embodiment includes an MSP430f449 chip of texas instruments, which has the characteristics of low voltage, low power consumption and high analog-to-digital conversion accuracy.

Referring to fig. 2, the upper computer outputs data as an intuitive image through a visualization technology, can directly judge whether blood sugar meets a normal range, and automatically records test time and test values.

Referring to fig. 3, blood sugar values of 70 diabetic patients are measured in a physiological state of 0.5-4 hours after fasting, so that energy loss and stable emotion of the testers before testing are avoided, the maximum measurement error is 15% by calculating and comparing 70 groups of blood sugar standard values measured by the traditional Chinese medical institutions and actual measurement values, the correlation coefficient between the actual measurement values and the standard values is 0.978, and the blood sugar detection range is 4-18 mmol/L.

Claims (4)

1. The utility model provides a portable noninvasive blood glucose detection device based on near-infrared optics, includes blood glucose collection system and host computer, characterized by: the blood sugar collecting device comprises a shell, a power module, a signal collecting module, a signal conditioning module and a signal collecting and transmitting module are integrated in the shell, the power module supplies power to the signal collecting module and the signal conditioning module, the signal conditioning module is connected with the signal collecting and transmitting module, the shell is provided with a collecting port for an ear lobe, the signal collecting module comprises a near infrared light emitting module and a receiving module for receiving the transmission light of the ear lobe, the near infrared light emitting module and the receiving module are respectively arranged at two sides of the collecting port, the receiving module converts the received light signal into a voltage signal and transmits the voltage signal to the signal conditioning module, the signal conditioning module amplifies, filters and changes the polarity of the voltage value transmitted by a higher level, the signal collecting and transmitting module controls the signal conditioning module and converts the voltage signal output by the signal conditioning module into a binary digital signal, the signal acquisition and transmission module is communicated and transmitted to the upper computer through a serial port, and a blood glucose concentration result is obtained through software processing.

2. The portable noninvasive blood glucose detection device based on near-infrared optics as claimed in claim 1, wherein said near-infrared light emitting module adopts L ED with wavelength of 1640-1660 nm for high frequency modulation, and said receiving module adopts photodiode.

3. The portable noninvasive blood glucose detecting device based on near-infrared optics as claimed in claim 1, wherein: the signal conditioning module adopts a high-speed operational amplifier OPA820 chip of Texas instruments.

4. The portable noninvasive blood glucose detecting device based on near-infrared optics as claimed in claim 1, wherein: the signal acquisition and transmission module comprises an MSP430f449 chip of Texas instruments.

Images