CN110051366A - A kind of carbon oxygen saturation detection device and method - Google Patents
A kind of carbon oxygen saturation detection device and method Download PDFInfo
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- CN110051366A CN110051366A CN201910294799.2A CN201910294799A CN110051366A CN 110051366 A CN110051366 A CN 110051366A CN 201910294799 A CN201910294799 A CN 201910294799A CN 110051366 A CN110051366 A CN 110051366A
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- A—HUMAN NECESSITIES
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- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
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- A61B5/74—Details of notification to user or communication with user or patient ; user input means
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Abstract
The present invention relates to a kind of carbon oxygen saturation detection devices, including probe unit, converting unit, processor and display screen, the probe unit includes the light source of detector and several different wave lengths, detector detection receives light intensity signal of the light of light source sending after arterial blood reflection in tissue, and light intensity signal is sent to converting unit；The converting unit is sent to processor after handling light intensity signal；Processor obtains carbon oxygen saturation to electric signal analysis.The invention further relates to a kind of carbon oxygen saturation detection methods, including LED light source, successively to tissue emissions optical signal, photodetector receives light intensity signal and is sent to AFE(analog front end)；AFE(analog front end) receives light intensity signal, and light intensity signal is converted to voltage signal, and discrete digital carbon oxygen signal is converted to after voltage signal filter amplifying processing and is sent to single-chip microcontroller；Single-chip microcontroller it is calculated carbon oxygen saturation.The present invention realizes and real-time monitoring noninvasive to carbon oxygen saturation in human body artery blood.
Description
Technical field
The present invention relates to carbon oxygen monitoring technical fields, and in particular to a kind of carbon oxygen saturation detection device and method.
Background technique
Carbonyl haemoglobin belongs to a kind of derivative of hemoglobin in blood of human body, is carbon monoxide and hemoglobin knot
The product of conjunction.In terms of binding ability, the binding ability of carbon monoxide and hemoglobin is oxygen and Hb BC hemoglobin binding capacity
200~300 times, in terms of dissociation rate, the dissociation rate of carbonyl haemoglobin only has the 1/3600 of oxyhemoglobin.
When human body largely sucks carbon monoxide, carbon monoxide replaces oxygen in conjunction with hemoglobin, enables the oxygen carrying of hemoglobin
Power sharply declines, and causes oxygen content in blood insufficient, generates anthracemia.The severity and carbon of anthracemia
Oxygen saturation is proportional, and normal human's carbon oxygen saturation is lower than 2.5%, and the intracorporal carbon oxygen saturation of long-term smoker is slightly higher
In normal level；When carbon oxygen saturation is 5%~10% in human body, expiratory dyspnea when having headache, inability, dizziness, labour
Etc. symptoms, if can appreciate that at this moment itself has the tendency that anthracemia and saves oneself in time effectively avoid one
Carbon monoxide poisoning, can often most people recognize oneself to be in poisoning edge and continue oneself activity at this time；When
Exacerbation of symptoms when internal carbon oxygen saturation reaches 10%~20%, patient's lip are in cherry-red, have Nausea and vomiting, consciousness mould
The symptoms such as paste, collapse or stupor, patient recognizes oneself to be poisoned but be difficult to complete to save oneself at this time, when carbon oxygen saturation >
When 50%, patient has brain edema, pulmonary edema, cardiac damage, arrhythmia cordis and respiration inhibition even dead more.
Currently, clinical principium judges that the method for patient's anthracemia is observation patient body state, pass through complexion, lip
Color, stupor degree do preliminary judgement, are substantially positioned in the level of subjective experience judgement, lack objective standard；Later to patient into
Carbonyl haemoglobin measurement, electroencephalogram etc. check in promoting circulation of blood, but are required to certain waiting time, can not accomplish it is real-time, continuous,
Non-invasive measurement patient's carbon oxygen saturation judges patient's intoxication conditions in turn.Although some fixed-site has been equipped with an oxygen
Change concentration of carbon detection and warning device, but if it is desired to each environment installation detecting device for may induce anthracemia
It is unpractical.Therefore, when carbon oxygen saturation is 5%~10% in human body, if device monitoring to carbon oxygen can be passed through at this moment
Saturation degree, and people is reminded to pay attention to occur the risk of anthracemia, people itself can take measures to save oneself at this time,
Anthracemia will be effectively avoided, if not having carbon oxygen saturation monitoring device, most people can not recognize oneself just
It is in poisoning edge and continues oneself activity, there is very big risk to health of human body.Therefore how to carry out noninvasive and supervise in real time
Carbon oxygen saturation in human body is surveyed, and carries out the technical issues of anthracemia early warning is urgent need to resolve.
Summary of the invention
The present invention is to solve the problems, such as that noninvasive and real-time monitoring can not be carried out to carbon oxygen saturation in human body in the prior art,
A kind of carbon oxygen saturation detection device and method are provided, realize in tissue in arterial blood carbon oxygen saturation it is noninvasive and
Real-time monitoring.To achieve the above object, the technical scheme is that
A kind of carbon oxygen saturation detection device, including probe unit, converting unit, processor and display screen, the detection
Unit includes the light source of detector and several different wave lengths, and detector detection receives the light of light source sending through arterial blood in tissue
Light intensity signal after reflection, and light intensity signal is sent to converting unit；
Light intensity signal is converted to electric signal, and is sent to processor after electric signal is handled by the converting unit；
The processor obtains the carbon oxygen saturation in final tissue for carrying out analytical calculation to electric signal；
The detection device further includes power supply, the power supply, for providing supply voltage VCC for detection device.
Further, the detector is photodetector；The light source is configured as the LED light of three different wave lengths
Source, the wavelength of the LED light source are respectively λ1、λ1And λ3；The wavelength X1Range be 590~670nm；The wavelength X2's
Range is 680~750nm；The wavelength X3Range be 760~860nm.
Further, the converting unit includes AFE(analog front end), the model AFE4900 of the AFE(analog front end)；
The processor includes single-chip microcontroller, the model MSP430f5529 of the single-chip microcontroller.
Further, the light source and detector are separately connected the I/O interface of single-chip microcontroller；
The port RESET and I2C_SPI_SEL of the AFE(analog front end) is separately connected P1.1 the and P1.2 interface of single-chip microcontroller；Institute
The port PROG_OUT1, CONTROL1 and ADC_RDY for stating AFE(analog front end) is separately connected P2.1, P2.2 and P2.3 of single-chip microcontroller and connects
Mouthful；The P1.0 interface of the port connection single-chip microcontroller of the CLK of the AFE(analog front end).
Further, the display screen use SSD1306 type display screen, CS, RES, DC, CLK of the display screen and
The port MOSI is separately connected P6.0~P6.4 interface of single-chip microcontroller.
Further, the single-chip microcontroller is connected with alarm unit, and the alarm unit includes buzzer and for driving bee
The base stage of the triode of ring device, the collector of the buzzer connecting triode, the triode passes through resistance R1 connection monolithic
The P6.6 interface of machine.
A kind of a kind of carbon oxygen saturation detection method based on carbon oxygen saturation detection device, comprising the following steps:
Step 1: three wavelength are λ1、λ1And λ3LED light source be spaced according to set time successively to tissue emissions light believe
Number, photodetector receives light intensity signal and is sent to AFE(analog front end)；
Step 2: AFE(analog front end) receives light intensity signal, light intensity signal is converted to voltage signal, later by voltage signal
Discrete digital carbon oxygen signal is converted to after filter amplifying processing, and digital carbon oxygen signal is sent to single-chip microcontroller；
Step 3: single-chip microcontroller carries out analytical calculation to digital carbon oxygen signal, obtains carbon oxygen saturation；And by carbon oxygen saturation
It is sent to display screen to be shown, alarm unit carries out audible alarm to the carbon oxygen saturation beyond single-chip microcontroller given threshold.
Further, the calculation formula of the carbon oxygen saturation is as follows:
Wherein, SPCO indicates carbon oxygen saturation, CHbCOIndicate the concentration of carbonyl haemoglobin,Indicate oxygenated blood red eggs
White concentration, CHbIndicate the concentration of reduced hemoglobin.
Further, the light source to the light intensity signal after tissue emissions include: when arterial blood all flows back into heart
Light intensity signal be IDC:
Wherein, ε is extinction coefficient, and l is the light path of light source in the tissue；
When arterial blood is most full, light intensity signal at this time are as follows:
Formula (2) subtracts each other to obtain with formula (3):
Wherein, IDCAnd IACIt is the DC amount and AC amount of light source light intensity in the tissue；△ l is at two kinds of arterial blood
The optical path difference of light source；
The maximum value and minimum value of the light intensity for the Same Wavelength light source that the photodetector detects are respectively ImaxWith
Imin；The Imin=IDC；The Imax-Imin=IAC。
Further, single-chip microcontroller carries out analytical calculation to digital carbon oxygen signal in the step 3, specifically includes:
Formula (4) are converted are as follows:
Photodetector is λ for the wavelength of detection1、λ1And λ3Be denoted as a, b, c respectively in formula (5), then,
Formula (5.1), (5.2) and (5.3) makees ratio, obtains:
Carbon oxygen saturation SPCO is obtained in conjunction with formula (1), (6.1), (6.2) and (6.3).
Through the above technical solutions, the invention has the benefit that
The present invention uses integrated simulation front-end A FE4900 chip, it is integrated with traditional light source driving circuit, operation amplifier
Circuit, A/D converter circuit and filter circuit, the stability that circuit is increased on the basis of more integrated improve measurement essence
Degree；Detection device has super low-power consumption, selects MSP430f5529 single-chip microcontroller, AFE4900 AFE(analog front end) is super low-power consumption device
Part, the display screen of use be also compared with low power consumption so that the present invention when in use between on be guaranteed.Simultaneously the present apparatus can by pair
Processor setting, enables detection device to play a variety of use patterns, does not have to the bright display screen of moment point, also substantially prolongs use
Time.The present invention is easily integrated, and the detection method thinking which utilizes is clear, and calculating is uncomplicated, and is avoided very much
The generation of error, improves detection accuracy, is easily integrated in analysis and Processing Algorithm, keeps detection device practicability stronger.
The present invention being capable of continuous, real-time detection normal person or in the patient's body arterial blood of anthracemia
The parameter of carbon oxygen saturation, normal person detect carbon oxygen saturation, for preventing or the generation of early warning anthracemia phenomenon；When
After patient's anthracemia, to avoid multiple blood test, it is full that carbon oxygen in patient blood can be observed in real time using this device
With the variation tendency of degree, the recovery situation of patient is judged with this, it is applied widely.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram of carbon oxygen saturation detection device of the present invention.
Fig. 2 is a kind of circuit diagram of the single-chip microcontroller of carbon oxygen saturation detection device of the present invention.
Fig. 3 is a kind of circuit diagram of the AFE(analog front end) of carbon oxygen saturation detection device of the present invention.
Fig. 4 is the circuit diagram of sensor DCM08 in the embodiment of the present invention 1.
Fig. 5 is the variation schematic diagram of light intensity in tissue in the embodiment of the present invention 2.
Fig. 6 is the testing result schematic diagram of the carbon oxygen saturation in the embodiment of the present invention 2.
Numbering in the drawing are as follows: 1 is single-chip microcontroller, and 2 be AFE(analog front end), and 3 be photodetector, and 4 be LED light source, and 5 be display
Screen, 6 be power supply.
Specific embodiment
Present invention will be further explained below with reference to the attached drawings and specific embodiments:
Embodiment 1: as shown in Figure 1 to 4, a kind of carbon oxygen saturation detection device, including probe unit, converting unit,
Processor and display screen 5, the probe unit include the light source of detector and several different wave lengths, and detector detection receives light source
Light intensity signal of the light of sending after arterial blood reflection in tissue, and light intensity signal is sent to converting unit；
Light intensity signal is converted to electric signal, and is sent to processor after electric signal is handled by the converting unit；
The processor obtains the carbon oxygen saturation in final tissue for carrying out analytical calculation to electric signal；
The detection device further includes power supply 6, the power supply 6, for providing supply voltage VCC for detection device.
It is preferably carried out mode as one kind, the detector is photodetector 3；The light source is configured as three not
The wavelength of the LED light source 4 of co-wavelength, the LED light source 4 is respectively λ1、λ1And λ3；The wavelength X1Range be 590~
670nm；The wavelength X2Range be 680~750nm；The wavelength X3Range be 760~860nm.
As an embodiment, detector and light source use sensor DCM08 in the present embodiment, and DCM08 is integrated can
It is 660 with launch wavelength, 730,850, four LED of 940nm light, while integrates one piece of photodetector 3；Wherein four LED
The driving current of common-anode design, the chip is 50mA, can directly be directly driven, not needed by AFE(analog front end) 2AFE4900 chip
Peripheral drive circuit；The present invention is only with three LED light sources 4 therein, the wavelength X of three LED light sources 41、λ1And λ3Respectively
660,730 and 850nm.Specifically, as shown in figure 4, DCM08 chip the port 660C connection AFE(analog front end) 2 the port TX1,
The port TX2 of the port the 730C connection AFE(analog front end) 2 of DCM08 chip, the port the 850C connection AFE(analog front end) 2 of DCM08 chip
The port TX3.
It is preferably carried out mode as one kind, the converting unit includes AFE(analog front end) 2, the model of the AFE(analog front end) 2
For AFE4900.
The processor includes single-chip microcontroller 1, as shown in Fig. 2, the model MSP430f5529 of the single-chip microcontroller 1；Specifically
, the port XIN with XOUT connects crystal oscillating circuit, and the crystal oscillator frequency that crystal oscillating circuit uses is 32.768KHz, the both ends of crystal oscillator
It is parallel with capacitor C69 and C70, the capacitor of capacitor C69 and C70 are 12pF.Single-chip microcontroller 1MSP430f5529 and AFE(analog front end)
2AFE4900 chip communication, processing resolve the digital signal that AFE4900 is sent back to, and final result are sent to display screen 5 and is shown
Show.MSP430f5529 single-chip microcontroller 1 not only has data processing speed block, high reliablity, super low-power consumption, strong antijamming capability etc.
Advantage, security performance is also very high, and the speed of service is also faster than traditional single-chip microcontroller 1, in addition to this, MSP430f5529 monolithic
Machine 1 has been internally integrated the very high clock of precision and the high reset circuit of reliability, to eliminate external reset circuit
Deng greatly reducing the setting of circuit, reduce the volume of detection device.
Specifically, as shown in figure 3, the light source and detector are separately connected the I/O interface of single-chip microcontroller 1；
The port RESET and I2C_SPI_SEL of the AFE(analog front end) 2 is separately connected P1.1 the and P1.2 interface of single-chip microcontroller 1；
The port PROG_OUT1, CONTROL1 and ADC_RDY of the AFE(analog front end) 2 be separately connected single-chip microcontroller 1 P2.1, P2.2 and
P2.3 interface；The P1.0 interface of the port connection single-chip microcontroller 1 of the CLK of the AFE(analog front end) 2.
It should be noted that the AFE(analog front end) 2AFE4900, be integrated with LED drive module, time-sequence control module, AD and turn
Block, filter and amplification module and I-V conversion module and controllable LED open circuit and the fault diagnosis circuit of short-circuit detecting etc. are changed the mold,
Module necessary to traditional sensing detection is integrated on the monolithic of very little, traditional peripheral circuit has been abandoned, avoids use
The disadvantages of discrete component bring is bulky, circuit debugging is difficult, power consumption is big；Wherein the most important LED for keeping it internal is passed
Defeated channel and PD receiving channel, LED transmission channel drive LED light source 4 to replace under suitable driving current with determining frequency
It shines；PD receiving channel is substantially carried out I-V conversion, photosignal correction, the AD conversion work of filtering circuit high-frequency noise；Mould
It can be by SPI/I between quasi- front end 2ADE4900 and single-chip microcontroller 1MSP430f55292C realizes data communication.
The display screen 5 uses SSD1306 type display screen, the port CS, RES, DC, CLK and MOSI point of the display screen 5
Not Lian Jie single-chip microcontroller 1 P6.0~P6.4 interface.
The single-chip microcontroller 1 is connected with alarm unit 7, and the alarm unit 7 is including buzzer and for driving buzzer
The base stage of triode, the collector of the buzzer connecting triode, the triode passes through resistance R1 connection single-chip microcontroller 1
P6.6 interface.
As an embodiment, the power supply 6 in the present embodiment uses CR1220 button cell, CR1220 button cell
It is stable 3V voltage for the supply voltage VCC that detection device provides.
This detection device is set as two kinds of working conditions at work:
The first is long term monitoring mode, and under such mode, device is started to work after being inserted into CR1220 button cell, single
Piece machine 1MSP430f5529 passes through SPI/I every 30s2C is communicated with AFE(analog front end) 2AFE4900, the LED driving in AFE4900
Module controls the light that DCM08 timesharing issues constant intensity, and specially every 50ms, three LED light sources 4 successively issue constant intensity
Light, when light all the way is acquired after the arterial blood back reflection in human skin tissue by the photodetector 3 of the same side, light
Light intensity signal is changed into current signal and is sent to AFE4900 by electric explorer 3, and chip interior I-V conversion module believes electric current
Number it is changed into discrete voltage signal, through filter and amplification module by the undistorted amplification of voltage signal, crosses noise filtering, then turned by AD
It is discrete digital carbon oxygen signal that block, which is changed the mold, by analog-signal transitions, by SPI/I2C is sent to single-chip microcontroller 1MSP430f5529.
After three kinds of different wavelength send a signal to single-chip microcontroller 1 in the above described manner, to the digital signal received inside single-chip microcontroller 1
It is calculated, when the carbon oxygen saturation being calculated is in the threshold range of setting, then carbon oxygen saturation parameter is normal, monolithic
Machine 1 does not light display screen 5, and system enters standby mode, until 30s is repeated the above process later.
Second is urgent monitoring pattern, and under the first monitoring pattern, the carbon oxygen saturation detected into the human body is more than
When given threshold, 1 control device of single-chip microcontroller enters urgent monitoring pattern；Single-chip microcontroller 1MSP430f5529 continues under this monitoring pattern
It is communicated with AFE4900, system is in continuous duty；LED drive module control DCM08 timesharing in AFE4900 issues permanent
Determine the light of intensity, every light all the way is after the arterial blood in human skin tissue by the photodetector 3 of the same side after diffusing reflection
Light intensity signal is changed into current signal and is sent to AFE4900 by acquisition, photodetector 3, and chip interior I-V conversion module will
Current signal is changed into discrete voltage signal, through filter and amplification module by the undistorted amplification of voltage signal, excessively noise filtering, then by
Analog-signal transitions are discrete digital carbon oxygen signal by AD conversion module, by SPI/I2C is sent to MSP430f5529.When three
After the different wavelength of kind sends a signal to single-chip microcontroller 1 in the above described manner, the digital signal received is carried out inside single-chip microcontroller 1
It calculates and result is simultaneously sent to display screen 5 by I/O mouthfuls in the form of percentage, while result is shown in wavy manner aobvious
In display screen 5, to monitor carbon oxygen saturation variation tendency, until carbon oxygen saturation restores normal or manual reset；At the same time
Single-chip microcontroller 1 drives alarm unit 7, and buzzer, which makes a sound, makes a sound alarm.
It should be noted that can be integrated into small volume portable for the carbon oxygen saturation detection device in the present embodiment, or
Person is the bracelet or other equipment of Worn type, and the present embodiment does not illustrate, but it not limits practical range of the invention, therefore
All equivalent change or modifications done according to structure, feature and principle described in the invention patent range, should be included in the present invention
In claim.
Embodiment 2: as shown in Fig. 5~6, a kind of carbon oxygen saturation detection side based on a kind of carbon oxygen saturation detection device
Method, comprising the following steps:
First it should be noted that the calculation formula of the carbon oxygen saturation is as follows:
Wherein, SPCO indicates carbon oxygen saturation, CHbCOIndicate the concentration of carbonyl haemoglobin, CHbO2Indicate oxygenated blood red eggs
White concentration, CHbIndicate the concentration of reduced hemoglobin.
Step 1: three wavelength are λ1、λ1And λ3LED light source 4 be spaced according to set time successively to tissue emissions light believe
Number, photodetector 3 receives light intensity signal and is sent to AFE(analog front end) 2；
The light source is to the light intensity signal after tissue emissions including two kinds: the light intensity when arterial blood all flows back into heart
Signal is IDC:
Wherein, ε is extinction coefficient, and l is the light path of light source in the tissue；The formula (1) is by Lambert-Beer's law
Mathematical expression is derived；
When arterial blood is most full, light intensity signal at this time are as follows:
Formula (2) subtracts each other to obtain with formula (3):
Wherein, IDCAnd IACIt is the DC amount and AC amount of light source light intensity in the tissue；△ l is at two kinds of arterial blood
The optical path difference of light source；
The maximum value and minimum value of the light intensity for the Same Wavelength light source that the photodetector 3 detects are respectively ImaxWith
Imin；It should be noted that photodetector 3 is unable to direct detection to the AC amount and DC amount of light intensity, photodetector 3 can only be visited
Measure the largest light intensity I of light source after reflectionmaxWith minimum intensity of light Imin, light intensity variation as shown in figure 5, in figure light intensity max value
The min value of namely wave crest, light intensity is trough；What max-min was obtained is exactly the amount changed, that is, of ac IAC, valley value
It is to stablize constant minimum value, that is, DC quantity IDC；Therefore the Imin=IDC；The Imax-Imin=IAC；Light intensity variation and
Curent change is consistent, therefore single-chip microcontroller 1 calculates the digital signal received, is equal to and calculates light intensity,
So still being calculated using light intensity value when calculating carbon oxygen saturation in step 3, calculated result does not influence completely.
Step 2: AFE(analog front end) 2 receives light intensity signal, light intensity signal is converted to voltage signal, later by voltage signal
Discrete digital carbon oxygen signal is converted to after filter amplifying processing, and digital carbon oxygen signal is sent to single-chip microcontroller 1；
Step 3: 1 pair of single-chip microcontroller digital carbon oxygen signal carries out analytical calculation, obtains carbon oxygen saturation；And by carbon oxygen saturation
It is sent to display screen 5 to be shown, alarm unit 7 carries out audible alarm to the carbon oxygen saturation beyond 1 given threshold of single-chip microcontroller.
1 pair of the single-chip microcontroller digital carbon oxygen signal carries out analytical calculation, specifically includes:
Formula (4) are converted are as follows:
Photodetector 3 is λ for the wavelength of detection1、λ1And λ3Be denoted as a, b, c respectively in formula (5), then,
Formula (5.1), (5.2) and (5.3) makees ratio, obtains:
Carbon oxygen saturation SPCO is obtained in conjunction with formula (1), (6.1), (6.2) and (6.3).
As an embodiment, alarm unit 7 described in the present embodiment is to the carbon oxygen for exceeding 1 given threshold of single-chip microcontroller
Saturation degree SPCO carries out audible alarm, and the threshold value of the carbon oxygen saturation SPCO that single-chip microcontroller 1 is set is 5%；When carbon oxygen saturation
SPCO is normal condition when being lower than 5%, when carbon oxygen saturation SPCO is higher than 5%, issues alarm.
It is that core builds detection with MSP430f5529 single-chip microcontroller 1 and AFE4900 AFE(analog front end) 2 based on above-mentioned detection method
Device since current anthracemia examination person difficulty such as looks at the odjective causes, utilizes the device only for the accuracy of proof theory
Centralized detecting is carried out to a large amount of normal subjects, testing result is as shown in Figure 3；
It is shown from the data in Fig. 3 as can be seen that average carbon oxygen saturation SPCO is in the arterial blood of subject
0.03456, it was demonstrated that the carbon oxygen saturation SPCO of subject is 3.456%, meets objective fact.It is higher for carbon oxygen saturation
Subject is analyzed, it is found that most of carbon oxygen saturation people with too high has long-term smoking history, the imperfect combustion of cigarette
Carbon monoxide can be generated, frequent smoking will lead to intracorporal carbon oxygen saturation numerical value and be slightly above normal person.Utilize inspection of the invention
Survey method it can be concluded that it is highly stable as a result, different crowd measurement result maximum difference be 0.0241, this is because the age,
Caused by life habit is different.Device stability based on the measuring principle is good, high sensitivity, is very suitable to human body carbon oxygen saturation
Spend the estimation of SPCO；There is very big application prospect for future prevention anthracemia.
The embodiment of the above, only presently preferred embodiments of the present invention, not limits practical range of the invention,
Therefore all equivalent change or modifications done according to structure, feature and principle described in the invention patent range, it should be included in this hair
In bright claim.
Claims (10)
1. a kind of carbon oxygen saturation detection device, which is characterized in that including probe unit, converting unit, processor and display screen
(5), the probe unit includes the light source of detector and several different wave lengths, and detector detection receives the light of light source sending through group
Light intensity signal after knitting arterial blood reflection, and light intensity signal is sent to converting unit；
Light intensity signal is converted to electric signal, and is sent to processor after electric signal is handled by the converting unit；
The processor obtains the carbon oxygen saturation in final tissue for carrying out analytical calculation to electric signal；
The detection device further includes power supply (6), the power supply (6), for providing supply voltage VCC for entire detection device.
2. a kind of carbon oxygen saturation detection device according to claim 1, which is characterized in that the detector is photoelectricity spy
It surveys device (3)；The light source is configured as the LED light source (4) of three different wave lengths, and the wavelength of the LED light source (4) is respectively
λ1、λ1And λ3；The wavelength X1Range be 590~670nm；The wavelength X2Range be 680~750nm；The wavelength X3
Range be 760~860nm.
3. a kind of carbon oxygen saturation detection device according to claim 1, which is characterized in that the converting unit includes mould
Quasi- front end (2), the model AFE4900 of the AFE(analog front end) (2)；
The processor includes single-chip microcontroller (1), the model MSP430f5529 of the single-chip microcontroller (1).
4. a kind of carbon oxygen saturation detection device according to claim 3, which is characterized in that the light source and detector point
Not Lian Jie single-chip microcontroller (1) I/O interface；
The port RESET and I2C_SPI_SEL of the AFE(analog front end) (2) is separately connected P1.1 the and P1.2 interface of single-chip microcontroller (1)；
The port PROG_OUT1, CONTROL1 and ADC_RDY of the AFE(analog front end) (2) is separately connected P2.1, P2.2 of single-chip microcontroller (1)
With P2.3 interface；The P1.0 interface of port connection single-chip microcontroller (1) of the CLK of the AFE(analog front end) (2).
5. a kind of carbon oxygen saturation detection device according to claim 3, which is characterized in that the display screen (5) uses
The port CS, RES, DC, CLK and MOSI of SSD1306 type display screen, the display screen (5) is separately connected the P6.0 of single-chip microcontroller (1)
~P6.4 interface.
6. a kind of carbon oxygen saturation detection device according to claim 3 and method, which is characterized in that the single-chip microcontroller
(1) it is connected with alarm unit (7), the alarm unit (7) includes buzzer and the triode for driving buzzer, the bee
The collector of ring device connecting triode, the base stage of the triode pass through the P6.6 interface of resistance R1 connection single-chip microcontroller (1).
7. based on a kind of a kind of described in any item carbon oxygen saturation detections of carbon oxygen saturation detection device of claim 1~6
Method, which comprises the following steps:
Step 1: three wavelength are λ1、λ1And λ3LED light source (4) be spaced according to set time successively to tissue emissions optical signal,
Photodetector (3) receives light intensity signal and is sent to AFE(analog front end) (2)；
Step 2: AFE(analog front end) (2) receives light intensity signal, and light intensity signal is converted to voltage signal, later filters voltage signal
Discrete digital carbon oxygen signal is converted to after wave enhanced processing, and digital carbon oxygen signal is sent to single-chip microcontroller (1)；
Step 3: single-chip microcontroller (1) carries out analytical calculation to digital carbon oxygen signal, obtains carbon oxygen saturation；And carbon oxygen saturation is sent out
It send to display screen (5) and is shown, alarm unit (7) carries out sound to the carbon oxygen saturation beyond single-chip microcontroller (1) given threshold
Alarm.
8. a kind of carbon oxygen saturation detection method according to claim 7, which is characterized in that the meter of the carbon oxygen saturation
It is as follows to calculate formula:
Wherein, SPCO indicates carbon oxygen saturation, CHbCOIndicate the concentration of carbonyl haemoglobin,Indicate oxyhemoglobin
Concentration, CHbIndicate the concentration of reduced hemoglobin.
9. a kind of carbon oxygen saturation detection method according to claim 7, which is characterized in that the light source is to tissue emissions
Light intensity signal afterwards includes: that the light intensity signal when arterial blood all flows back into heart is IDC:
Wherein, ε is extinction coefficient, and l is the light path of light source in the tissue；
When arterial blood is most full, light intensity signal at this time are as follows:
Formula (2) subtracts each other to obtain with formula (3):
Wherein, IDCAnd IACIt is the DC amount and AC amount of light source light intensity in the tissue；△ l is the light source at two kinds of arterial blood
Optical path difference；
The maximum value and minimum value of the light intensity for the Same Wavelength light source that the photodetector (3) is detected are respectively ImaxWith
Imin；The Imin=IDC；The Imax-Imin=IAC。
10. a kind of carbon oxygen saturation detection method according to claim 7, which is characterized in that single-chip microcontroller in the step 3
(1) analytical calculation is carried out to digital carbon oxygen signal, specifically included:
Formula (4) are converted are as follows:
Photodetector (3) is λ for the wavelength of detection1、λ1And λ3Be denoted as a, b, c respectively in formula (5), then,
Formula (5.1), (5.2) and (5.3) makees ratio, obtains:
Carbon oxygen saturation SPCO is obtained in conjunction with formula (1), (6.1), (6.2) and (6.3).
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