CN202305465U - Saliva glucose concentration acquisition device - Google Patents
Saliva glucose concentration acquisition device Download PDFInfo
- Publication number
- CN202305465U CN202305465U CN2011202976424U CN201120297642U CN202305465U CN 202305465 U CN202305465 U CN 202305465U CN 2011202976424 U CN2011202976424 U CN 2011202976424U CN 201120297642 U CN201120297642 U CN 201120297642U CN 202305465 U CN202305465 U CN 202305465U
- Authority
- CN
- China
- Prior art keywords
- electrochemical reaction
- saliva
- sample
- collecting portion
- glucose concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn - After Issue
Links
Images
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a saliva glucose concentration acquisition device which is characterized by comprising a sample acquisition part, an electrochemical reaction tank, and an electrical signal transmission conducting wire, wherein the sample acquisition part is made from polyurethane foam and used for acquiring saliva samples; the electrochemical reaction tank is filled with riboflavin adenine nucleotide complexation glucose dehydrogenase and allows the saliva sample acquired by the sample acquisition part to be subjected to electrochemical reaction; the electrical signal transmission conducting wire is connected with the electrochemical reaction tank, so as to allow the current generated by the electrochemical reaction tank to be transmitted to a host machine; and the insulation layer is arranged at the periphery of the electrochemical reaction tank. The acquisition device has the advantages that through the polyurethane adsorption technology, the nano microsphere package enzyme technology, and the electrochemical reaction signal capture and processing technology, the saliva with lower glucose content is an ideal detection sample, and the blood-glucose concentration can be detected indirectly through detecting the saliva glucose concentration based on the positive correlation of the saliva glucose concentration and the blood-glucose concentration; and besides, the device has the characteristics of simple structure, convenience in production and low cost, and is suitable for wide popularization.
Description
Technical field
The utility model relates to a kind of saliva sugar concentration deriving means.
Background technology
(self-monitoring of blood glucose SMBG) is the international at present extensively diabetes management methods of approval to diabetic oneself blood sugar monitoring.And blood glucose meter market is huge both at home and abroad; Various brand instruments are multifarious; But principle of work is similar, all needs aculeus blood-taking to come more or less (0.3-10 microlitre) to collect whole blood sample, and scientific and reasonable every day of 5-6 the meeting of detection adds up every annual nearly 2000 times acupuncture wound of suffering from.
In recent years, studied multiple can reaching in the world and do not had the technology that wound detects the blood sugar purpose, also had some corresponding instruments to come out, but do not had a easy and simple to handlely so far, measured stablely, moderate portable non-invasive blood glucose meter is extensively approved by market.As: near-infrared spectrum technique; When with near infrared ray irradiation human body, with the irrelevant tissue of blood sugar, like skin, bone, muscle, water etc.; To absorb most of infrared ray; The reflection of remaining a small amount of representative blood sugar characteristic or absorption infrared ray are called blood sugar characteristic frequency spectrum signal, can be used to extract blood glucose value.The problem of this method is: blood sugar characteristic frequency spectrum signal often very a little less than, be difficult to measure; This signal is relevant with body temperature and body fluid components, must proofread and correct.The U.S. one company once produced and used this technological instrument-Diasensor, and the bodily form is bigger, costs an arm and a leg, and can't make accurate detection to hypoglycaem ic condition, so still in constantly debugging and researching and developing.The reverse ion electrophoretic techniques; Subcutaneous interstitial fluid be a kind of composition near the extracellular fluid of blood, nutriments such as glucose need to arrive cell via subcutaneous interstitial fluid.The reverse ion electrophoretic techniques can make subcutaneous interstitial fluid ooze out skin on a small quantity, like this, just can not have wound and obtains the subcutaneous interstitial fluid sample, records blood glucose value.Gluco-watch is to use this technological moulding instrument, has obtained FDA approval listing, but its stability and hypoglycemic omission behaved always denounces.The RF impedance technology; When electromagnetic wave irradiation skin, nonionic solable matters such as subcutaneous glucose can absorb certain electromagnetic wave, draw concentration of glucose through calculating absorption value.PENDRA was abroad once arranged, and pertinent instruments such as GLUCOBAND occur, but because of costing an arm and a leg, accuracy is on the low side and the market of fading out.Also have some based on the temperature check method, nuclear magnetic resonance method, subcutaneous implant electrode method, the instrument of the graceful rays method of thunder etc. is developed, but all very immature.And the positive correlation of saliva sugar concentration and blood sugar concentration, for a kind of novel blood sugar concentration monitoring means provides the possible of new technology realization.But according to existing achievement in research, what primarily solve is exactly the problem of gathering.
Summary of the invention
The utility model is directed against the proposition of above problem, and develops a kind of saliva sugar concentration deriving means.The technological means that the utility model adopts is following:
A kind of saliva sugar concentration deriving means is characterized in that comprising:
Be configured for gathering the sample collecting portion of saliva sample by polyurethane foam;
Be filled with lactochrome adenylic acid complexing GDH, the saliva sample that is used to make sample collecting portion to gather carries out the electrochemical reaction groove of electrochemical reaction;
Be connected on the electrochemical reaction groove, be used for the electric signal transfer wire of the conduction of current that produces in the electrochemical reaction groove to the main frame;
Said sample collecting portion is fixed on the electrochemical reaction groove;
Said electrochemical reaction groove outside is provided with insulation course.
The lactochrome adenylic acid complexing GDH of filling in the said electrochemical reaction groove is wrapped on the glass nano microballoon.
Lactochrome adenylic acid complexing GDH in the said electrochemical reaction groove or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing GDH are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Also comprise and be used to monitor the threshold alerts unit whether saliva that sample collecting portion gathers reaches collection capacity; Said threshold alerts unit comprises: be set in around the sample collecting portion humidity sensor that the humidity of sample collecting portion is detected;
Connect humidity sensor, the detected humidity value of humidity sensor is compared with preset threshold, after humidity value reaches setting threshold, send the single-chip microcomputer of alerting signal;
Connect single-chip microcomputer, the alerting signal that single-chip microcomputer sends is carried out corresponding alarm unit;
Be connected on the loop that humidity sensor, single-chip microcomputer and alarm unit constitute, to the unlatching of circuit or close the switch of controlling.
The advantage of the said device of the utility model is: through using the polyurethane adsorption technology; Nano microsphere parcel zymotechnic and electrochemical reaction signal capture treatment technology; Make the lower saliva of glucose content become desirable detection sample; Based on the positive correlation of saliva sugar concentration and blood sugar concentration, start with the indirect determination blood sugar concentration from measuring saliva sugar concentration.Utilize the rapid a large amount of collected specimens of strong absorbent of PU; Utilize the highly effective reaction property of Nano microsphere that whole glucose in the sample are carried out enzymic catalytic reaction; Produce electric current and be convenient to the size of main frame (being detecting instrument) through electric current and be calculated to be concentration of glucose, thereby reach the purpose of not having wound calibrating blood sugar; Detect the pain that is caused and infect the risk that infects to reduce the tradition blood sampling.In addition, this device also has simple in structure, be convenient to produce, and characteristics with low cost, be suitable for extensive popularization.
Description of drawings
Fig. 1 is the structural representation of the said device of the utility model;
Fig. 2 is the structural representation of the threshold alerts unit of the said device of the utility model.
Among the figure: 1, sample collecting portion, 2, the electrochemical reaction groove, 201, insulation course, 3, the electric signal transfer wire, 4, the threshold alerts unit, 401, humidity sensor, 402, single-chip microcomputer, 403, alarm unit, 404, switch.
Embodiment
The described saliva sugar of the utility model as shown in Figure 1 concentration deriving means; Comprise: the sample collecting portion 1 (the utility model adopts Soft PU foam, is because Soft PU foam has good bio-compatibility and high-speed and high-efficiency absorbability) that is configured for gathering saliva sample by polyurethane foam; (the utility model adopts lactochrome adenylic acid complexing GDH to be filled with lactochrome adenylic acid complexing GDH; Because of GDH has anti-oxidant; For the high characteristics of glucose selectivity, the false positive reaction of having avoided the interference because of maltose, galactose and wood sugar to cause.), the saliva sample that is used to make sample collecting portion 1 to gather carries out the electrochemical reaction groove 2 of electrochemical reaction; Be connected on the electrochemical reaction groove 2; Be used for the electric signal transfer wire 3 of the conduction of current that produce in the electrochemical reaction groove 2 to the main frame; Main frame can adopt a coulomb coulometry; I.e. reaction produces whole electric currents and all includes calculating in, ensures that the LG sample still can be by accurate detection, and calculates through related function saliva sugar concentration and blood sugar concentration are informed the user; Said sample collecting portion 1 is fixed on the electrochemical reaction groove 2; Said electrochemical reaction groove 2 outsides are provided with insulation course 201, ensure that all kinetic currents are all uploaded seizure; The lactochrome adenylic acid complexing GDH of filling in the said electrochemical reaction groove 2 is wrapped in (the Nano microsphere diameter is about 5-50nm) on the glass nano microballoon, can increase reaction area and glucose response efficient like this; Lactochrome adenylic acid complexing GDH in the said electrochemical reaction groove 2 or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing GDH are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Because of the result of the amount of gathering saliva and detection has direct relation (magnitude of current as the sample of same people microlitre saliva of same stages 100 produces is fixed); Therefore for obtaining testing result more accurately; After sample collecting portion collects the ormal weight saliva sample; Corresponding prompt must be arranged, and the amount of prompting collected specimens is enough.Therefore this device this device as shown in Figure 2 also comprises and is used to monitor the threshold alerts unit 4 whether saliva that sample collecting portion 1 gathers reaches collection capacity; Said threshold alerts unit 4 comprises: be set in around the sample collecting portion 1; The humidity sensor 401 that the humidity of sample collecting portion 1 is detected is (according to the solubleness of collection portion absorption of water and saliva; The corresponding position of the harvester of same specification is the identical principle of its humidity under the identical situation of collection capacity; And the employing humidity sensor, present embodiment adopts capacitive humidity sensor; According to the sample collecting portion 1 of different model with sensor settings in corresponding position, this process need parameter testing, debug process is collection capacity with the signal of the conduction process to coupling, is techniques well known, is not elaborated here); Connect humidity sensor 401, humidity sensor 401 detected humidity values are compared with preset threshold, after humidity value reaches setting threshold, send the single-chip microcomputer 402 of alerting signal; Connect single-chip microcomputer 402, the alerting signal that single-chip microcomputer 402 sends is carried out corresponding alarm unit 403, said alarm unit 403 can also can be luminous warning for audible alarm, perhaps has the function of sound and light alarm simultaneously; Be connected on the loop that humidity sensor 401, single-chip microcomputer 402 and alarm unit 403 constitute, to the unlatching of circuit or close the switch of controlling 404.
The above; Be merely the preferable embodiment of the utility model; But the protection domain of the utility model is not limited thereto; Any technician who is familiar with the present technique field is equal to replacement or changes according to the technical scheme of the utility model and inventive concept thereof in the technical scope that the utility model discloses, and all should be encompassed within the protection domain of the utility model.
Claims (3)
1. saliva sugar concentration deriving means is characterized in that comprising:
Be configured for gathering the sample collecting portion (1) of saliva sample by polyurethane foam;
Be filled with lactochrome adenylic acid complexing GDH, the saliva sample that is used to make sample collecting portion (1) to gather carries out the electrochemical reaction groove (2) of electrochemical reaction;
Be connected on the electrochemical reaction groove (2), be used for the electric signal transfer wire (3) of the conduction of current that produces in the electrochemical reaction groove (2) to the main frame;
Said sample collecting portion (1) is fixed on the electrochemical reaction groove (2);
Said electrochemical reaction groove (2) outside is provided with insulation course (201).
2. a kind of saliva sugar concentration deriving means according to claim 1 is characterized in that the lactochrome adenylic acid complexing GDH of filling in the said electrochemical reaction groove (2) is wrapped on the glass nano microballoon.
3. a kind of saliva sugar concentration deriving means according to claim 1 is characterized in that also comprising being used to monitor the threshold alerts unit (4) whether saliva that sample collecting portion (1) gathers reaches collection capacity; Said threshold alerts unit (4) comprising: be set in sample collecting portion (1) on every side, the humidity sensor (401) that the humidity of sample collecting portion (1) is detected;
Connect humidity sensor (401), the detected humidity value of humidity sensor (401) is compared with preset threshold, after humidity value reaches setting threshold, send the single-chip microcomputer (402) of alerting signal;
Connect single-chip microcomputer (402), the alerting signal that single-chip microcomputer (402) sends is carried out corresponding alarm unit (403);
Be connected on the loop that humidity sensor (401), single-chip microcomputer (402) and alarm unit (403) constitute, to the unlatching of circuit or close the switch of controlling (404).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202976424U CN202305465U (en) | 2011-08-16 | 2011-08-16 | Saliva glucose concentration acquisition device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011202976424U CN202305465U (en) | 2011-08-16 | 2011-08-16 | Saliva glucose concentration acquisition device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202305465U true CN202305465U (en) | 2012-07-04 |
Family
ID=46374337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011202976424U Withdrawn - After Issue CN202305465U (en) | 2011-08-16 | 2011-08-16 | Saliva glucose concentration acquisition device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202305465U (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102384931A (en) * | 2011-08-16 | 2012-03-21 | 苏州悦安医疗电子有限公司 | Salivary glucose concentration acquiring device |
| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| CN105615897A (en) * | 2016-04-05 | 2016-06-01 | 京东方科技集团股份有限公司 | Blood glucose monitoring device and blood glucose monitoring method |
| WO2020151440A1 (en) * | 2019-01-25 | 2020-07-30 | 京东方科技集团股份有限公司 | Saliva test device and system, and operating method thereof |
-
2011
- 2011-08-16 CN CN2011202976424U patent/CN202305465U/en not_active Withdrawn - After Issue
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102384931A (en) * | 2011-08-16 | 2012-03-21 | 苏州悦安医疗电子有限公司 | Salivary glucose concentration acquiring device |
| CN102384931B (en) * | 2011-08-16 | 2013-10-09 | 苏州悦安医疗电子有限公司 | Salivary glucose concentration acquiring device |
| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| CN105615897A (en) * | 2016-04-05 | 2016-06-01 | 京东方科技集团股份有限公司 | Blood glucose monitoring device and blood glucose monitoring method |
| WO2017173867A1 (en) * | 2016-04-05 | 2017-10-12 | 京东方科技集团股份有限公司 | Apparatus for monitoring blood glucose, and monitoring method therefor |
| CN105615897B (en) * | 2016-04-05 | 2018-12-18 | 京东方科技集团股份有限公司 | A kind of blood sugar monitor and its monitoring method |
| WO2020151440A1 (en) * | 2019-01-25 | 2020-07-30 | 京东方科技集团股份有限公司 | Saliva test device and system, and operating method thereof |
| US20210204917A1 (en) * | 2019-01-25 | 2021-07-08 | Boe Technology Group Co., Ltd. | Saliva detection device, saliva detection system and operation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102323310B (en) | Noninvasive blood sugar monitoring system | |
| CN110338813B (en) | Noninvasive blood glucose detection method based on spectrum analysis | |
| CN202305465U (en) | Saliva glucose concentration acquisition device | |
| CN105510388B (en) | Wearable sweat pH value detection device | |
| CN103190917B (en) | Laser Raman technique-based glucometer | |
| WO2006010310A1 (en) | Apparatus and method for non-invasive monitoring of blood components using pulsewave impedance spectra | |
| CN100482154C (en) | Portable near-infrared detection apparatus for human body local plasma volume variation parameter | |
| CN203220371U (en) | Wireless portable noninvasive blood glucose detector | |
| CN109222946A (en) | Physio-parameter detection system and detection method based on optical fiber pad | |
| CN103499621A (en) | Noninvasive blood glucose monitor | |
| WO2021082259A1 (en) | Ecg electrocardiographic measurement mode switching method and apparatus, and wearable device and storage medium | |
| CN102384931B (en) | Salivary glucose concentration acquiring device | |
| CN110575182A (en) | Method and device for detecting blood sugar | |
| CN105816186A (en) | Noninvasive type automated hand-held blood analyzer | |
| CN202204794U (en) | Noninvasive glucose monitoring system | |
| KR20110094405A (en) | Method for non-invasive glucose measurement and non-invasive glucose measuring apparatus using the same method | |
| CN202939150U (en) | Glucometer | |
| CN205658894U (en) | Infrared sphygmometer based on singlechip | |
| CN202364268U (en) | Flip cellphone with blood flow detecting function | |
| CN103876749A (en) | Built-in spectroscopy rapid blood glucose detection system | |
| CN203587549U (en) | Noninvasive blood glucose monitor | |
| CN204318765U (en) | A kind of infrared spectrum technology non-invasive blood-sugar detecting instrument | |
| CN210631213U (en) | Physical health testing device based on Internet of things | |
| CN205433707U (en) | A supplementary clip for non -invasive glucose concentration detection | |
| CN206534644U (en) | Portable noninvasive blood glucose detector based on DSP technologies |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20120704 Effective date of abandoning: 20131009 |
|
| RGAV | Abandon patent right to avoid regrant |