CN203587549U - Noninvasive blood glucose monitor - Google Patents
Noninvasive blood glucose monitor Download PDFInfo
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- CN203587549U CN203587549U CN201320661683.6U CN201320661683U CN203587549U CN 203587549 U CN203587549 U CN 203587549U CN 201320661683 U CN201320661683 U CN 201320661683U CN 203587549 U CN203587549 U CN 203587549U
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- electrochemical reaction
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- reaction groove
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Abstract
The utility model discloses a noninvasive blood glucose monitor which is provided with a sample collection part, an electrochemical reaction tank and an electric signal transmission wire, wherein the sample collection part consists of polyurethane foam and is used for collecting a saliva sample; the electrochemical reaction tank is filled with flavin adenine nucleotide complexing with glucose dehydrogenase and is used for performing an electrochemical reaction on the saliva sample collected by the sample collection part; the electric signal transmission wire is connected to the electrochemical reaction tank and is used for conducting the current generated in the electrochemical reaction tank to a host; the sample collection part is fixed on the electrochemical reaction tank; an insulating layer is arranged at the periphery of the electrochemical reaction tank. The noninvasive blood glucose monitor according to the utility model has the advantages that pure saliva can be rapidly collected, the defect in the traditional operation of obtaining salivary sugar is overcome, and a mode of rapidly and accurately obtaining the salivary sugar is provided for salivary sugar detection. Moreover, the adopted technology is mature, low in cost and suitable for wide-range popularization and application.
Description
Technical field
The present invention relates to a kind of blood-sugar detecting instrument, relate in particular to a kind of non-invasive blood-sugar detecting instrument.
Background technology
Along with the change of the remarkable decline of modern humans's labour intensity and eating habit, and the aggravation of aging population, the incidence of disease of diabetes rises rapidly, and diabetes and complication thereof cause affects oneself becomes one of the serious public health problem that must face countries in the world.Increasing diabetic needs the every day of blood sugar in body is carried out timing or being monitored at any time according to physical condition repeatedly, general patient need to detect 5-6 time blood sugar every day, and the blood glucose meter of selling on existing market is mostly wound, need acupuncture treatment to get blood, within 1 year, will cause the needle stick injury of 2000 left and right, so many wound, not only to patient, bring very big inconvenience, make patient suffer misery, but also likely cause wound infection, be unfavorable for the frequent detection of blood sugar.Blood sugar detects the focus that becomes domestic and international blood sugar test research without wound.
For the major defect that has wound blood sugar test, people start diversion to efficient, on Woundless blood sugar detects easily.Having come out now a lot of without wound detection method, is mainly by scanning human body skin, hypodermis liquid or blood etc.But because disturbing factor in human body is a lot, blood sugar does not have single, special absorption peak yet, make optical means accuracy in detection and sensitivity all not satisfactory.
Occurred now multiplely by check saliva sugar, indirectly measuring the method and apparatus of blood sugar, but all had the problem that saliva is obtained inconvenience and the saliva that gets is contained more bubble.
Summary of the invention
The present invention is directed to the proposition of above problem, and a kind of Woundless blood sugar monitor of development is characterized in that having: saliva sugar concentration acquisition device;
Described saliva sugar concentration acquisition device has:
By polyurethane foam, be configured for gathering the sample collection portion of saliva sample;
Be filled with lactochrome adenylic acid complexing glucose dehydrogenase, for the saliva sample that sample collection portion is gathered, carry out the electrochemical reaction groove of electrochemical reaction;
Be connected on electrochemical reaction groove, for the electric current producing in electrochemical reaction groove being transmitted to the electric signal transmission wire on main frame;
Described sample collection portion is fixed on electrochemical reaction groove;
Described electrochemical reaction groove outside is provided with insulation course;
Described sample collection portion has the profile matching with lower teeth on human body, comprising: the outer wall in laminating tooth outside, the inwall of laminating tooth inner side, connect the link slot of described outer wall and inwall, be fixed on multiple conductive poles of link slot upper surface;
Described outer wall, inwall and link slot have respectively end and two afterbodys of arch, end and front tooth laminating, and described afterbody is fitted with molar respectively;
During use, upper and lower dental articulation, described link slot between upper lower teeth, fit the respectively interior outside of tooth of outer wall and inwall, multiple conductive poles energisings, saliva stimulating glandular secretion saliva;
Described link slot has gradient: the thickness of two afterbodys of described link slot is greater than the thickness of end;
The saliva of secretion enters after link slot via tooth, in the end of link slot, collects;
Described electrochemical reaction groove, is connected with described outer wall; Described outer wall has for saliva by entering the breach of electrochemical reaction groove; The saliva of collecting in link slot end enters electrochemical reaction groove by this breach;
Described electrochemical reaction groove inside has carrying and the thin slice of ptyaloreaction material and the volute spring of the described thin slice of support; Described thin slice) be fixed in helical spring gap;
Saliva enters in described electrochemical reaction groove to be reacted with the material carrying on described thin slice.
On described thin slice, load has the glass nano microballoon with lactochrome adenylic acid complexing glucose dehydrogenase.
In described electrochemical reaction groove with material ptyaloreaction be: lactochrome adenylic acid complexing glucose dehydrogenase or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing glucose dehydrogenase are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Also comprise whether the saliva for monitoring the collection of sample collection portion reaches the threshold alerts unit of collection capacity; Described threshold alerts unit comprises: be set in around sample collection portion the humidity sensor that the humidity of sample collection portion is detected.
The advantage of Woundless blood sugar monitor of the present invention is: can the pure saliva of quick obtaining, shortcoming while having avoided tradition to obtain saliva sugar, for detecting, saliva sugar provides a kind of quick, accurately obtain the mode of saliva, and the technology maturation adopting, with low cost, be suitable for promoting on a large scale and using.
Accompanying drawing explanation
Fig. 1 is structured flowchart of the present invention
Fig. 2 is the schematic diagram I of display unit of the present invention
Fig. 3 is the schematic diagram II of display unit of the present invention
Fig. 4 is the schematic diagram of saliva sugar concentration acquisition device of the present invention
Fig. 5 is the structured flowchart of saliva sugar concentration acquisition device control gear of the present invention
Fig. 6 is the structural representation of sample collection of the present invention portion
Fig. 7 is the side view of sample collection of the present invention portion
In figure: 1. sample collection portion, 2. electrochemical reaction groove, 3. electric signal transmission wire, 4. threshold alerts unit, 401. humidity sensors, 402. single-chip microcomputers, 403. alarm units, 404. switches, 5. signal processing unit, 6. processor, 7. storage unit, 8. display unit, 9. display unit, 13. outer walls, 14. inwalls, 12. link slots, 11. conductive poles, 21. thin slices, 22. volute springs, 23. breach.
Embodiment
Fig. 1 is structured flowchart of the present invention, Fig. 4 is the schematic diagram of saliva sugar concentration acquisition device of the present invention, Fig. 5 is the structured flowchart of saliva sugar concentration acquisition device control gear of the present invention, by Fig. 1, a kind of Woundless blood sugar monitor shown in 4,5 mainly has saliva sugar concentration acquisition device and the processing host for obtaining saliva sugar content;
Preferably saliva of the present invention sugar concentration acquisition device as shown in Figure 4, comprising: the 1(the present invention of sample collection portion who is configured for gathering saliva sample by polyurethane foam adopts Soft PU foam, is because Soft PU foam has good bio-compatibility and high-speed and high-efficiency absorbability); (the present invention adopts lactochrome adenylic acid complexing glucose dehydrogenase to be filled with lactochrome adenylic acid complexing glucose dehydrogenase, because glucose dehydrogenase has anti-oxidant, for the high feature of glucose selectivity, avoided the false positive reaction causing because of the interference of maltose, galactose and wood sugar.), for making saliva sample that sample collection portion 1 gathers carry out the electrochemical reaction groove 2 of electrochemical reaction; Be connected on electrochemical reaction groove 2, for the electric current of electrochemical reaction groove 2 interior generations is transmitted to the electric signal transmission wire 3 on main frame, main frame can adopt a coulomb coulometry, i.e. reaction produces whole electric currents and all includes calculating in, ensure that LG sample still can accurately be detected, and calculate saliva sugar concentration and blood sugar concentration are informed to user by related function; Described sample collection portion 1 is fixed on electrochemical reaction groove 2; Described electrochemical reaction groove 2 outsides are provided with insulation course 201, ensure that all kinetic currents are all uploaded seizure; The lactochrome adenylic acid complexing glucose dehydrogenase of described electrochemical reaction groove 2 interior fillings is wrapped in (Nano microsphere diameter is about 5-50nm) on glass nano microballoon, can increase like this reaction area and glucose response efficiency; Lactochrome adenylic acid complexing glucose dehydrogenase in described electrochemical reaction groove 2 or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing glucose dehydrogenase are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Experiment showed, the secretion that can accelerate saliva by the salivary gland of electro photoluminescence human body, traditional mode of obtaining saliva, process is very loaded down with trivial details, needs cotton balls to draw enough salivas, then extracts cotton balls, process is loaded down with trivial details, and the saliva solution of extruding is polluted by cotton balls; The saliva of collecting can be contained certain bubble.
In order conveniently to obtain pure saliva, as preferred embodiment, adopt the structure of similar facing or denture fixing device etc. to collect saliva: described sample collection portion 1 and lower teeth on the human body profile matching of arranging, comprise: at the outer wall 13 of outside laminating tooth, at the inwall 14 of inner side laminating tooth, connect the link slot 12 of described outer wall 13 and inwall 14, be fixed on multiple conductive poles 11 of link slot 12 upper surfaces.
Described outer wall 13, inwall 14 and link slot 12 have respectively end and two afterbodys of arch, end and front tooth laminating, and afterbody is fitted with molar respectively;
During use, upper and lower dental articulation, described link slot 12 between upper lower teeth, fit the respectively interior outside of tooth of outer wall 13 and inwall 14, multiple conductive poles 11 are switched on, saliva stimulating glandular secretion saliva;
Described link slot 12 has gradient: the thickness of 12 two afterbodys of described link slot is greater than the thickness of end.
The saliva of secretion is entered after link slot 12 by tooth, in the end of link slot 12, collects; Described electrochemical reaction groove 2, is connected with described outer wall 13; Described outer wall 13 has for saliva by entering the breach 23 of electrochemical reaction groove 2; The saliva of collecting in link slot 12 ends enters electrochemical reaction groove 2 by this breach; Described electrochemical reaction groove 2 inside have the thin slice 21 of carrying and ptyaloreaction material, the volute spring 22 of described thin slice 21 and the described thin slice of support; Described thin slice 21 is fixed in the gap of volute spring 22; Saliva enters in described electrochemical reaction groove 2 to be reacted with the material of carrying on described thin slice 21.
Adopt volute spring the thin slice 21 that is loaded with ptyaloreaction material can be fixed on to specific height, when saliva arrives height, react and send electronics with material, electronics is received by electric signal transmission wire 3.
Itself can be used as sparking electrode volute spring, as an embodiment preferably, can adopt glucose dehydrogenase type electrode to participate in reaction.When saliva liquid level exceedes certain height, can react, save the device of controlling saliva amount.
Because gathering the amount of saliva and the result of detection, there is direct relation to fix as the magnitude of current that the sample of same people's same stage 100 microlitre salivas produces, therefore for obtaining more accurately testing result, when sample collection portion collects after ormal weight saliva sample, must have corresponding prompting, the amount of prompting collected specimens is enough.Therefore this device as shown in Figure 5 this device also comprise the threshold alerts unit 4 that whether reaches collection capacity for monitoring saliva that sample collection portion 1 gathers; Described threshold alerts unit 4 comprises: be set in around sample collection portion 1, the humidity sensor 401 that the humidity of sample collection portion 1 is detected is according to the solubleness of collection portion absorption of water and saliva, the corresponding position of harvester of same specification identical principle of its humidity in the situation that collection capacity is identical, and employing humidity sensor, the present embodiment adopts capacitive humidity sensor; According to the sample collection portion 1 of different model by sensor settings in corresponding position, this process need parameter testing, debug process be collection capacity with conduction signal to coupling process, be techniques well known, be not elaborated here; Connect humidity sensor 401, the humidity value that humidity sensor 401 is detected compares with the threshold value of setting, and sends the single-chip microcomputer 402 of alerting signal after humidity value reaches setting threshold; Connect single-chip microcomputer 402, the alerting signal that single-chip microcomputer 402 is sent is carried out corresponding alarm unit 403, and described alarm unit 403 can also can be luminous alarm for audible alarm, or has the function of sound and light alarm simultaneously; Be connected on the loop that humidity sensor 401, single-chip microcomputer 402 and alarm unit 403 form the unlatching to circuit or close the switch 404 of controlling.
Preferably, processing host as shown in Figure 1 comprises: the physics and chemistry signal that described saliva sugar concentration acquisition device is obtained is converted to the signal processing unit 5 of electric signal, because electric conductivity and the saliva sugar concentration of sialic saccharide solution have certain relation, as an embodiment preferably, described signal processing unit 5 mainly will be in described sugar juice a coulomb electricity be converted to 6 electric signal that can identify of processor.
Because processor 6 need to be born signal conversion processing, the work such as data base call modification, graphic interface demonstration and touch control, the task weight of bearing, current data traffic is large, therefore general single-chip microcomputer is not competent, preferably, here select domestic ARM Cortex A8 architecture processor " auspicious core micro-2918 ", as previous generation compacting instruction set processor, there is enough powerful calculation process, supporting development technique maturation simultaneously, cost again can be not unattainable as ARM Cortex A9 dual core processor price of new generation.
Because needs are stored a large amount of patients' blood glucose level data, normally according to blood glucose level data storehouse, and be loaded with diet database, memory space is larger, therefore select popular on the market microSD card, Mobile phone card is as the storage medium of storage unit 7.Simultaneously, in described blood glucose level data storehouse, also store the blood sugar secure threshold that the patient doctor in charge sets, when patient's blood glucose value of measuring exceedes this threshold value, processor 6 is understood in display unit 8 display alarm information, and sends alerting signal by the alarm unit 9 being directly connected with processor 6 with wireless transmission interface.
Preferably, select, with controlling with the touch-screen of input function as display unit 8, whole main frame to be made like this and similarly volume of mobile phone size, to be convenient for carrying.
When concrete use, first patient inputs diet information by display unit 8, comprise dietetic variety quantity, processor 6 receive this type of information after, call the data that in storage unit 7, diet database is recorded, through calculating, can draw the sugar information of taking in by diet, comprise: sugared intake and the time of diet.Simultaneously, processor 6 obtains the electric signal that signal processing unit 5 transmits, change into corresponding blood glucose value, and the blood glucose value of gained is presented on display unit 8, multiple blood glucose values of the former period that this blood glucose value is recorded with individual blood glucose level data storehouse in storage unit 7 are associated, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting is with reference to blood glucose curve, by described blood glucose value, blood glucose curve and being presented on display unit 8 with reference to blood glucose curve, upgrade the correlation parameter of each database in storage unit 7 simultaneously.
According to sugared intake and the time of diet last time, with the blood glucose value recording together by compare draw one relative, fixing glycemic index voluntarily, value 1-100,90-100 is kilter, and now patient can not take any hypoglycemic measure, such as intravenous injection insulin etc.; 70-90 is for taking medicine state, and patient is according to the positive informal dress antidiabetic drug of doctor's advice.Below 70, be precarious position, remind patient to seek medical advice immediately and send information to family numbers of patients.
The above; it is only preferably embodiment of the present invention; but protection scope of the present invention is not limited to this; any be familiar with those skilled in the art the present invention disclose technical scope in; according to technical scheme of the present invention and inventive concept thereof, be equal to replacement or changed, within all should being encompassed in protection scope of the present invention.
Claims (4)
1. a Woundless blood sugar monitor, is characterized in that having: saliva sugar concentration acquisition device;
Described saliva sugar concentration acquisition device has:
By polyurethane foam, be configured for gathering the sample collection portion (1) of saliva sample;
Be filled with lactochrome adenylic acid complexing glucose dehydrogenase, for the saliva sample that sample collection portion (1) is gathered, carry out the electrochemical reaction groove (2) of electrochemical reaction;
Be connected to electrochemical reaction groove (2) upper, for the electric current producing in electrochemical reaction groove (2) is transmitted to the electric signal transmission wire (3) on main frame;
Described sample collection portion (1) is fixed on electrochemical reaction groove (2);
Described electrochemical reaction groove (2) outside is provided with insulation course (201);
Described sample collection portion (1) has the profile matching with lower teeth on human body, comprise: the outer wall (13) in laminating tooth outside, the inwall (14) of laminating tooth inner side, connect the link slot (12) of described outer wall (13) and inwall (14), be fixed on multiple conductive poles (11) of link slot (12) upper surface;
Described outer wall (13), inwall (14) and link slot (12) have respectively end and two afterbodys of arch, end and front tooth laminating, and described afterbody is fitted with molar respectively;
During use, upper and lower dental articulation, described link slot (12) between upper lower teeth, fit the respectively interior outside of tooth of outer wall (13) and inwall (14), multiple conductive poles (11) are switched on, saliva stimulating glandular secretion saliva;
Described link slot (12) has gradient: the thickness of two afterbodys of described link slot (12) is greater than the thickness of end;
The saliva of secretion enters after link slot (12) via tooth, in the end of link slot (12), collects;
Described electrochemical reaction groove (2), is connected with described outer wall (13); Described outer wall (13) has for saliva by entering the breach (23) of electrochemical reaction groove (2); The saliva of collecting in link slot (12) end enters electrochemical reaction groove (2) by this breach;
Described electrochemical reaction groove (2) inside has carrying and the thin slice (21) of ptyaloreaction material and the volute spring (22) of the described thin slice of support; Described thin slice (21) is fixed in the gap of volute spring (22);
Saliva enters in described electrochemical reaction groove (2) to be reacted with the material of the upper carrying of described thin slice (21).
2. a kind of Woundless blood sugar monitor according to claim 1, is characterized in that the upper load of described thin slice (21) has the glass nano microballoon with lactochrome adenylic acid complexing glucose dehydrogenase.
3. a kind of Woundless blood sugar monitor according to claim 1 and 2, is characterized in that the material with ptyaloreaction in described electrochemical reaction groove (2) is: lactochrome adenylic acid complexing glucose dehydrogenase or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing glucose dehydrogenase are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
4. a kind of Woundless blood sugar monitor according to claim 1, characterized by further comprising for monitoring the saliva that sample collection portion (1) gathers whether reach the threshold alerts unit (4) of collection capacity; Described threshold alerts unit (4) comprising: be set in sample collection portion (1) around, the humidity sensor (401) that the humidity of sample collection portion (1) is detected.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320661683.6U CN203587549U (en) | 2013-10-22 | 2013-10-22 | Noninvasive blood glucose monitor |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320661683.6U CN203587549U (en) | 2013-10-22 | 2013-10-22 | Noninvasive blood glucose monitor |
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| Publication Number | Publication Date |
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| CN203587549U true CN203587549U (en) | 2014-05-07 |
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| CN201320661683.6U Expired - Fee Related CN203587549U (en) | 2013-10-22 | 2013-10-22 | Noninvasive blood glucose monitor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| CN105615897A (en) * | 2016-04-05 | 2016-06-01 | 京东方科技集团股份有限公司 | Blood glucose monitoring device and blood glucose monitoring method |
-
2013
- 2013-10-22 CN CN201320661683.6U patent/CN203587549U/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| CN105615897A (en) * | 2016-04-05 | 2016-06-01 | 京东方科技集团股份有限公司 | Blood glucose monitoring device and blood glucose monitoring method |
| WO2017173867A1 (en) * | 2016-04-05 | 2017-10-12 | 京东方科技集团股份有限公司 | Apparatus for monitoring blood glucose, and monitoring method therefor |
| CN105615897B (en) * | 2016-04-05 | 2018-12-18 | 京东方科技集团股份有限公司 | A kind of blood sugar monitor and its monitoring method |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140507 Termination date: 20181022 |