CN102323310A - Noninvasive blood sugar monitoring system - Google Patents
Noninvasive blood sugar monitoring system Download PDFInfo
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- CN102323310A CN102323310A CN201110234260A CN201110234260A CN102323310A CN 102323310 A CN102323310 A CN 102323310A CN 201110234260 A CN201110234260 A CN 201110234260A CN 201110234260 A CN201110234260 A CN 201110234260A CN 102323310 A CN102323310 A CN 102323310A
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Abstract
The invention discloses a noninvasive blood sugar monitoring system comprising a salivary sugar concentration acquisition device which collects a saliva sample and acquires physical and chemical signals in the saliva sample; a processing host which measures and calculates a current blood sugar value according to the physical and chemical signals, allows the blood sugar value to communicate with multiple blood sugar values of previous periods recorded in a personal blood sugar database in a memory cell, plots a personal blood sugar curve, allows a processor to call blood sugar data of corresponding periods in a healthy blood sugar database, plots a reference blood sugar curve, and then displays the blood sugar value, the blood sugar curve and the reference blood sugar curve; a remote monitoring center which receives the blood sugar value sent by the processing host, displays and stores the value. Based on the positive correlation between the salivary sugar concentration and the blood sugar concentration, the noninvasive blood sugar monitoring system provided by the invention determines the blood sugar concentration indirectly by starting with the measurement of the salivary sugar concentration; compared with present apparatus based on noninvasive blood sugar monitoring technology, the invention has the advantages of simple operations, carrying convenience, high accuracy of measuring results, and good apparatus stability.
Description
Technical field
The invention belongs to the blood sugar test technical field, relate in particular to a Woundless blood sugar monitoring system.
Background technology
(self-monitoring of blood glucose SMBG) is the international at present extensively diabetes management methods of approval to diabetic oneself blood sugar monitoring.Conventional blood sugar monitoring needs acupuncture to gather peripheral blood, and scientific and reasonable every day of 5-6 detection can add up every annual nearly 2000 times acupuncture wound of suffering from, and for this reason, has now the Woundless blood sugar monitoring technology is provided, and existing Woundless blood sugar monitoring technology mainly contains:
1. near-infrared spectrum technique.When with near infrared ray irradiation human body, with the irrelevant tissue of blood sugar, like skin, bone, muscle, water etc.; To absorb most of infrared ray; The reflection of remaining a small amount of representative blood sugar characteristic or absorption infrared ray are called blood sugar characteristic frequency spectrum signal, can be used to extract blood glucose value.The problem of this method is: blood sugar characteristic frequency spectrum signal often very a little less than, be difficult to measure; This signal is relevant with body temperature and body fluid components, and monitoring result is inaccurate, must proofread and correct.The U.S. one company once produced and used this technological instrument-Diasensor, and the bodily form is bigger, costs an arm and a leg, and can't make accurate detection to hypoglycaem ic condition, so still in constantly debugging and researching and developing.
2. reverse ion electrophoretic techniques.Subcutaneous interstitial fluid be a kind of composition near the extracellular fluid of blood, nutriments such as glucose need to arrive cell via subcutaneous interstitial fluid.The reverse ion electrophoretic techniques can make subcutaneous interstitial fluid ooze out skin on a small quantity, like this, just can not have wound and obtains the subcutaneous interstitial fluid sample, records blood glucose value.Gluco-watch is to use this technological moulding instrument, has obtained FDA approval listing, but its stability and hypoglycemic omission behaved always denounces.
3. RF impedance is technological.When electromagnetic wave irradiation skin, nonionic solable matters such as subcutaneous glucose can absorb certain electromagnetic wave, draw concentration of glucose through calculating absorption value.PENDRA was abroad once arranged, and pertinent instruments such as GLUCOBAND occur, but because of costing an arm and a leg, accuracy is on the low side and the market of fading out.
4. other is such as based on the temperature check method, nuclear magnetic resonance method, and subcutaneous implant electrode method, the instrument of the graceful rays method of thunder etc. is developed, Monitoring Data is inaccurate, the problem of stability of instrument difference but all exist.
In sum, existing instrument based on the Woundless blood sugar monitoring technology exists that complex operation, monitoring result error are big, the problem of stability of instrument difference.
Summary of the invention
The object of the present invention is to provide a Woundless blood sugar monitoring system, have to solve existing instrument that complex operation, monitoring result error are big, the problem of stability of instrument difference based on the Woundless blood sugar monitoring technology.
The invention provides a kind of Woundless blood sugar monitoring system, have: gather saliva sample and obtain the saliva sugar concentration deriving means (101) of the physics and chemistry signal in this saliva sample; Connect saliva sugar concentration deriving means (101); Calculating current blood glucose value according to this physics and chemistry signal also interrelates a plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in this blood glucose value and the storage unit; Draw individual blood glucose curve; Simultaneously processor calls the blood glucose level data of corresponding period in the healthy blood glucose level data storehouse, draws with reference to behind the blood glucose curve, shows blood glucose value, blood glucose curve and with reference to the processing host (102) of blood glucose curve; Through cable network or wireless network connection processing main frame (102), receive the blood glucose value of processing host (102) transmission and the remote monitoring center (103) that shows, stores.
Said processing host (102) can be through Internet connection with remote monitoring center (103).
Said processing host (102) also can be connected through mobile communications network with remote monitoring center (103).
Said saliva sugar concentration deriving means further has:
Be configured for gathering the sample collecting portion (1) of saliva sample by polyurethane foam;
Be filled with lactochrome adenylic acid complexing GDH, the saliva sample that is used to make sample collecting portion (1) to gather carries out the electrochemical reaction groove (2) of electrochemical reaction;
Be connected on the electrochemical reaction groove (2), be used for the electric signal transfer wire (3) of the conduction of current that produces in the electrochemical reaction groove (2) to the main frame;
Said sample collecting portion (1) is fixed on the electrochemical reaction groove (2);
Said electrochemical reaction groove (2) outside is provided with insulation course (201);
Said processing host further comprises:
The physics and chemistry conversion of signals that said saliva sugar concentration deriving means is obtained is the signal processing unit of electric signal;
Reception is also handled the electric signal that said signal processing unit sends, and calculates the processor of current blood glucose value;
Be pre-stored with the patient individual blood glucose level data storehouse that has the blood sugar secure threshold, the storage unit of healthy blood glucose level data storehouse and diet database; And
The display unit that has control and input function;
The blood glucose value that said processor will be handled gained is presented on the display unit; A plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in this blood glucose value and the storage unit are interrelated, draw individual blood glucose curve, processor calls the blood glucose level data of corresponding period in the healthy blood glucose level data storehouse simultaneously; Drafting is with reference to blood glucose curve; With said blood glucose value, blood glucose curve and be presented on the display unit, the correlation parameter of each database in the updated stored unit simultaneously with reference to blood glucose curve;
In display unit, import food variety; Feed quantity and eating time; Processor calculates total sugar content of feed according to the contained sugar of the varieties of food items of putting down in writing in the diet database, and according to the blood glucose value that obtains in meal time and the above-mentioned steps; Section was done and was relatively drawn comprehensive glycemic index detection time, and this index is presented on the display unit.
The lactochrome adenylic acid complexing GDH of further, filling in the said electrochemical reaction groove (2) is wrapped on the glass nano microballoon.
Further, lactochrome adenylic acid complexing GDH in the said electrochemical reaction groove (2) or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing GDH are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Further, also comprise and be used to monitor the threshold alerts unit (4) whether saliva that sample collecting portion (1) gathers reaches collection capacity; Said threshold alerts unit (4) comprising: be set in sample collecting portion (1) on every side, the humidity sensor (401) that the humidity of sample collecting portion (1) is detected;
Connect humidity sensor (401), the detected humidity value of humidity sensor (401) is compared with preset threshold, after humidity value reaches setting threshold, send the single-chip microcomputer (402) of alerting signal;
Connect single-chip microcomputer (402), the alerting signal that single-chip microcomputer (402) sends is carried out corresponding alarm unit (403);
Be connected on the loop that humidity sensor (401), single-chip microcomputer (402) and alarm unit (403) constitute, to the unlatching of circuit or close the switch of controlling (404).
Further also have: alarm unit (9); Be set with the normal range threshold value of comprehensive glycemic index in the said individual blood glucose level data storehouse; When processor (7) detects said glycemic index and exceeds threshold value, go up display alarm information at display unit (8), control alarm unit (9) simultaneously and report to the police.
Further also have the stationary installation of fixing saliva sugar concentration deriving means (101) and processing host (102), this stationary installation is an elastoplast, and the joint of this bandage is provided with velcro.
Woundless blood sugar monitoring system provided by the invention is based on the positive correlation of saliva sugar concentration and blood sugar concentration; Start with from measuring saliva sugar concentration; The indirect determination blood sugar concentration; Existing for existing instrument based on the Woundless blood sugar monitoring technology, have easy and simple to handle, be easy to carry, advantage such as measurement result degree of accuracy height and instrument stabilizer are good.
Description of drawings
Fig. 1 is the structural drawing of Woundless blood sugar monitoring system provided by the invention;
Fig. 2 is the structural drawing of saliva sugar concentration deriving means among Fig. 1;
Fig. 3 is the further structural drawing of saliva sugar concentration deriving means among Fig. 1.
Embodiment
In order to make the object of the invention, technical scheme and advantage clearer,, the present invention is further elaborated below in conjunction with accompanying drawing and embodiment.Should be appreciated that specific embodiment described herein only in order to explanation the present invention, and be not used in qualification the present invention.
As shown in Figure 1, Woundless blood sugar monitoring system provided by the invention comprises: gather saliva sample and obtain the saliva sugar concentration deriving means 101 of the physics and chemistry signal in this saliva sample; Connect saliva sugar concentration deriving means 101; Calculating current blood glucose value according to this physics and chemistry signal also interrelates a plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in this blood glucose value and the storage unit; Draw individual blood glucose curve; Simultaneously processor calls the blood glucose level data of corresponding period in the healthy blood glucose level data storehouse, draws with reference to behind the blood glucose curve, shows blood glucose value, blood glucose curve and with reference to the processing host 102 of blood glucose curve; Through cable network or wireless network connection processing main frame 102, receive the blood glucose value of processing host 102 transmissions and the remote monitoring center 103 that shows, stores.
Cable network wherein can be the internet, and wireless network wherein can be mobile communications network or other electric communication network, and this mobile communications network is preferably GPRS network.
In addition, this system also comprises the stationary installation of fixing saliva sugar concentration deriving means 101 and processing host 102, and this stationary installation is an elastoplast, and the joint of this bandage is provided with velcro.
As shown in Figure 2, saliva sugar concentration deriving means 101 comprises: the sample collecting portion 1 that is configured for gathering saliva sample by polyurethane foam; Be filled with lactochrome adenylic acid complexing GDH, the saliva sample that is used to make sample collecting portion 1 to gather carries out the electrochemical reaction groove 2 of electrochemical reaction; Be connected on the electrochemical reaction groove 2, be used for the electric signal transfer wire 3 of the conduction of current that produce in the electrochemical reaction groove 2 to the main frame; Sample collecting portion 1 is fixed on the electrochemical reaction groove 2; Electrochemical reaction groove 2 outsides are provided with insulation course 201.
The lactochrome adenylic acid complexing GDH of wherein, filling in the electrochemical reaction groove 2 is wrapped on the glass nano microballoon.
Wherein, lactochrome adenylic acid complexing GDH in the electrochemical reaction groove 2 or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing GDH are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
In conjunction with Fig. 2 and shown in Figure 3, saliva sugar concentration deriving means 101 also comprises and is used to monitor the threshold alerts unit 4 whether saliva that sample collecting portion 1 gathers reaches collection capacity; Said threshold alerts unit 4 comprises: be set in around the sample collecting portion 1 humidity sensor 401 that the humidity of sample collecting portion 1 is detected; Connect humidity sensor 401, humidity sensor 401 detected humidity values are compared with preset threshold, after humidity value reaches setting threshold, send the single-chip microcomputer 402 of alerting signal; Connect single-chip microcomputer 402, the alerting signal that single-chip microcomputer 402 sends is carried out corresponding alarm unit 403; Be connected on the loop that humidity sensor 401, single-chip microcomputer 402 and alarm unit 403 constitute, to the unlatching of circuit or close the switch of controlling 404.
Further, processing host 102 comprises: the physics and chemistry conversion of signals that saliva sugar concentration deriving means 101 is obtained is the signal processing unit of electric signal; Reception is also handled the electric signal that said signal processing unit sends, and calculates the processor of current blood glucose value; Be pre-stored with the patient individual blood glucose level data storehouse that has the blood sugar secure threshold, the storage unit of healthy blood glucose level data storehouse and diet database; And the display unit that has control and input function; The blood glucose value that processor will be handled gained is presented on the display unit; A plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in this blood glucose value and the storage unit are interrelated, draw individual blood glucose curve, processor calls the blood glucose level data of corresponding period in the healthy blood glucose level data storehouse simultaneously; Drafting is with reference to blood glucose curve; With said blood glucose value, blood glucose curve and be presented on the display unit, the correlation parameter of each database in the updated stored unit simultaneously with reference to blood glucose curve; In display unit, import food variety; Feed quantity and eating time; Processor calculates total sugar content of feed according to the contained sugar of the varieties of food items of putting down in writing in the diet database, and according to the blood glucose value that obtains in meal time and the above-mentioned steps; Section was done and was relatively drawn comprehensive glycemic index detection time, and this index is presented on the display unit;
Further; Processing host 102 also comprises: the alarm unit of connection processing device; Be set with the normal range threshold value of comprehensive glycemic index in individual's blood glucose level data storehouse; When processor detected said glycemic index and exceeds threshold value, display alarm information on display unit was controlled alarm unit simultaneously and is reported to the police.
Woundless blood sugar monitoring system provided by the invention is based on the positive correlation of saliva sugar concentration and blood sugar concentration; Start with from measuring saliva sugar concentration; The indirect determination blood sugar concentration; Existing for existing instrument based on the Woundless blood sugar monitoring technology, have easy and simple to handle, be easy to carry, advantage such as measurement result degree of accuracy height and instrument stabilizer are good.
The above; Be merely the preferable embodiment of the present invention; But protection scope of the present invention is not limited thereto; Any technician who is familiar with the present technique field is equal to replacement or change according to technical scheme of the present invention and inventive concept thereof in the technical scope that the present invention discloses, all should be encompassed within protection scope of the present invention.
Claims (9)
1. Woundless blood sugar monitoring system is characterized in that having:
Gather saliva sample and obtain the saliva sugar concentration deriving means (101) of the physics and chemistry signal in this saliva sample;
Connect saliva sugar concentration deriving means (101); Calculating current blood glucose value according to this physics and chemistry signal also interrelates a plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in this blood glucose value and the storage unit; Draw individual blood glucose curve; Simultaneously processor calls the blood glucose level data of corresponding period in the healthy blood glucose level data storehouse, draws with reference to behind the blood glucose curve, shows blood glucose value, blood glucose curve and with reference to the processing host (102) of blood glucose curve;
Through cable network or wireless network connection processing main frame (102), receive the blood glucose value of processing host (102) transmission and the remote monitoring center (103) that shows, stores.
2. Woundless blood sugar monitoring system as claimed in claim 1 is characterized in that said processing host (102) and remote monitoring center (103) are through Internet connection.
3. Woundless blood sugar monitoring system as claimed in claim 1 is characterized in that said processing host (102) is connected through mobile communications network with remote monitoring center (103).
4. Woundless blood sugar monitoring system as claimed in claim 1 is characterized in that said saliva sugar concentration deriving means has:
Be configured for gathering the sample collecting portion (1) of saliva sample by polyurethane foam;
Be filled with lactochrome adenylic acid complexing GDH, the saliva sample that is used to make sample collecting portion (1) to gather carries out the electrochemical reaction groove (2) of electrochemical reaction;
Be connected on the electrochemical reaction groove (2), be used for the electric signal transfer wire (3) of the conduction of current that produces in the electrochemical reaction groove (2) to the main frame;
Said sample collecting portion (1) is fixed on the electrochemical reaction groove (2);
Said electrochemical reaction groove (2) outside is provided with insulation course (201);
Said processing host comprises:
The physics and chemistry conversion of signals that said saliva sugar concentration deriving means is obtained is the signal processing unit of electric signal;
Reception is also handled the electric signal that said signal processing unit sends, and calculates the processor of current blood glucose value;
Be pre-stored with the patient individual blood glucose level data storehouse that has the blood sugar secure threshold, the storage unit of healthy blood glucose level data storehouse and diet database; And
The display unit that has control and input function;
The blood glucose value that said processor will be handled gained is presented on the display unit; A plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in this blood glucose value and the storage unit are interrelated, draw individual blood glucose curve, processor calls the blood glucose level data of corresponding period in the healthy blood glucose level data storehouse simultaneously; Drafting is with reference to blood glucose curve; With said blood glucose value, blood glucose curve and be presented on the display unit, the correlation parameter of each database in the updated stored unit simultaneously with reference to blood glucose curve;
In display unit, import food variety; Feed quantity and eating time; Processor calculates total sugar content of feed according to the contained sugar of the varieties of food items of putting down in writing in the diet database, and according to the blood glucose value that obtains in meal time and the above-mentioned steps; Section was done and was relatively drawn comprehensive glycemic index detection time, and this index is presented on the display unit.
5. Woundless blood sugar monitoring system as claimed in claim 4 is characterized in that the lactochrome adenylic acid complexing GDH of filling in the said electrochemical reaction groove (2) is wrapped on the glass nano microballoon.
6. like claim 4 or 5 described Woundless blood sugar monitoring systems, the glass nano microballoon that it is characterized in that the lactochrome adenylic acid complexing GDH in the said electrochemical reaction groove (2) or be enclosed with lactochrome adenylic acid complexing GDH is dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
7. Woundless blood sugar monitoring system as claimed in claim 4 is characterized in that also comprising being used to monitor the threshold alerts unit (4) whether saliva that sample collecting portion (1) gathers reaches collection capacity; Said threshold alerts unit (4) comprising: be set in sample collecting portion (1) on every side, the humidity sensor (401) that the humidity of sample collecting portion (1) is detected;
Connect humidity sensor (401), the detected humidity value of humidity sensor (401) is compared with preset threshold, after humidity value reaches setting threshold, send the single-chip microcomputer (402) of alerting signal;
Connect single-chip microcomputer (402), the alerting signal that single-chip microcomputer (402) sends is carried out corresponding alarm unit (403);
Be connected on the loop that humidity sensor (401), single-chip microcomputer (402) and alarm unit (403) constitute, to the unlatching of circuit or close the switch of controlling (404).
8. Woundless blood sugar monitoring system as claimed in claim 4; It is characterized in that also having: alarm unit (9); Be set with the normal range threshold value of comprehensive glycemic index in the said individual blood glucose level data storehouse; When processor (7) detects said glycemic index and exceeds threshold value, go up display alarm information at display unit (8), control alarm unit (9) simultaneously and report to the police.
9. Woundless blood sugar monitoring system as claimed in claim 4 is characterized in that also having the stationary installation of fixing saliva sugar concentration deriving means (101) and processing host (102), and this stationary installation is an elastoplast, and the joint of this bandage is provided with velcro.
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| CN201110234260.1A CN102323310B (en) | 2011-08-16 | 2011-08-16 | Noninvasive blood sugar monitoring system |
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| CN201110234260.1A CN102323310B (en) | 2011-08-16 | 2011-08-16 | Noninvasive blood sugar monitoring system |
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| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| RU2598344C2 (en) * | 2014-04-25 | 2016-09-20 | Тахир Хусанович Холматов | Conductometric method for non-invasive blood sugar measurement, device for implementation of the conductometric method with non-invasive measurement of blood sugar |
| CN107003316A (en) * | 2014-12-19 | 2017-08-01 | 三星电子株式会社 | Non-invasive blood glucose measuring method and device |
| CN107951492A (en) * | 2017-11-16 | 2018-04-24 | 天津大学 | A kind of noninvasive dynamics monitoring device |
| CN108474781A (en) * | 2016-12-21 | 2018-08-31 | 韩国运动科技有限公司 | Using saliva diagnostic device and utilize its diagnostic method |
| CN109682873A (en) * | 2019-01-25 | 2019-04-26 | 京东方科技集团股份有限公司 | A kind of saliva detection device and system |
| CN110873751A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Purine sensor and purine uptake control method |
| CN113171090A (en) * | 2021-03-12 | 2021-07-27 | 中山大学 | Diabetes monitoring and treating device and system based on mesoporous microneedle |
| CN111820955B (en) * | 2020-07-27 | 2021-09-10 | 南方科技大学 | Intelligent device is gathered to portable pharynx swab |
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| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| RU2598344C2 (en) * | 2014-04-25 | 2016-09-20 | Тахир Хусанович Холматов | Conductometric method for non-invasive blood sugar measurement, device for implementation of the conductometric method with non-invasive measurement of blood sugar |
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| CN108474781A (en) * | 2016-12-21 | 2018-08-31 | 韩国运动科技有限公司 | Using saliva diagnostic device and utilize its diagnostic method |
| CN107951492A (en) * | 2017-11-16 | 2018-04-24 | 天津大学 | A kind of noninvasive dynamics monitoring device |
| CN110873751A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Purine sensor and purine uptake control method |
| CN109682873A (en) * | 2019-01-25 | 2019-04-26 | 京东方科技集团股份有限公司 | A kind of saliva detection device and system |
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| CN111820955B (en) * | 2020-07-27 | 2021-09-10 | 南方科技大学 | Intelligent device is gathered to portable pharynx swab |
| CN113171090A (en) * | 2021-03-12 | 2021-07-27 | 中山大学 | Diabetes monitoring and treating device and system based on mesoporous microneedle |
| CN113171090B (en) * | 2021-03-12 | 2023-09-26 | 中山大学 | Diabetes monitoring and treatment device and system based on mesoporous microneedle |
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