CN102323310B - Noninvasive blood sugar monitoring system - Google Patents
Noninvasive blood sugar monitoring system Download PDFInfo
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- CN102323310B CN102323310B CN201110234260.1A CN201110234260A CN102323310B CN 102323310 B CN102323310 B CN 102323310B CN 201110234260 A CN201110234260 A CN 201110234260A CN 102323310 B CN102323310 B CN 102323310B
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Abstract
The invention discloses a noninvasive blood sugar monitoring system comprising a salivary sugar concentration acquisition device which collects a saliva sample and acquires physical and chemical signals in the saliva sample; a processing host which measures and calculates a current blood sugar value according to the physical and chemical signals, allows the blood sugar value to communicate with multiple blood sugar values of previous periods recorded in a personal blood sugar database in a memory cell, plots a personal blood sugar curve, allows a processor to call blood sugar data of corresponding periods in a healthy blood sugar database, plots a reference blood sugar curve, and then displays the blood sugar value, the blood sugar curve and the reference blood sugar curve; a remote monitoring center which receives the blood sugar value sent by the processing host, displays and stores the value. Based on the positive correlation between the salivary sugar concentration and the blood sugar concentration, the noninvasive blood sugar monitoring system provided by the invention determines the blood sugar concentration indirectly by starting with the measurement of the salivary sugar concentration; compared with present apparatus based on noninvasive blood sugar monitoring technology, the invention has the advantages of simple operations, carrying convenience, high accuracy of measuring results, and good apparatus stability.
Description
Technical field
The invention belongs to blood sugar test technical field, relate in particular to a Noninvasive blood sugar monitoring system.
Background technology
Diabetic's oneself's blood sugar monitoring (self-monitoring of blood glucose, SMBG) is the diabetes management methods that the world is extensively approved at present.Conventional blood sugar monitoring needs acupuncture to gather peripheral blood, and scientific and reasonable 5-6 detection every day can add up every trouble and often be close on the acupuncture wound of 2000 times, for this reason, the existing Woundless blood sugar monitoring technology that provides, existing Woundless blood sugar monitoring technology mainly contains:
1. near-infrared spectrum technique.When irradiating human body with near infrared ray, with the irrelevant tissue of blood sugar, as skin, bone, muscle, water etc., to absorb most of infrared ray, remaining reflection or the absorption infrared ray that represents on a small quantity blood sugar feature, is called blood sugar characteristic frequency spectrum signal, can be used to extract blood glucose value.The problem of this method is: blood sugar characteristic frequency spectrum signal is often very weak, is difficult to measure; This signal is relevant with body temperature and body fluid components, and monitoring result is inaccurate, must proofread and correct.The U.S. one company once produced the instrument-Diasensor that uses this technology, and the bodily form is larger, expensive, cannot make accurate detection to hypoglycaem ic condition, so still in constantly debugging and researching and developing.
2. reverse ion electrophoretic techniques.Subcutaneous interstitial fluid is the extracellular fluid that a kind of composition approaches blood most, and the nutriments such as glucose need arrive cell via subcutaneous interstitial fluid.Reverse ion electrophoretic techniques can make subcutaneous interstitial fluid ooze out on a small quantity skin, like this, just can obtain subcutaneous interstitial fluid sample without wound, records blood glucose value.Gluco-watch is the moulding instrument that uses this technology, has obtained FDA approval listing, but its stability and undetectedly behave and denounce always hypoglycemic.
3. radio-frequency (RF) impedance technology.When electromagnetic wave irradiation skin, the nonionic solable matters such as subcutaneous glucose can absorb certain electromagnetic wave, by calculating absorption value, draw concentration of glucose.Once had PENDRA abroad, the pertinent instruments such as GLUCOBAND occur, but because of expensive, accuracy is on the low side and the market of fading out.
4. other is such as based on temperature check method, nuclear magnetic resonance method, and subcutaneous implant electrode method, the instrument of the graceful rays method of thunder etc. is developed, but all has the problem that Monitoring Data is inaccurate, stability of instrument is poor.
In sum, the existing instrument based on Woundless blood sugar monitoring technology exists that complex operation, monitoring result error are large, the poor problem of stability of instrument.
Summary of the invention
The object of the present invention is to provide a Noninvasive blood sugar monitoring system, to solve the existing instrument based on Woundless blood sugar monitoring technology, have that complex operation, monitoring result error are large, the poor problem of stability of instrument.
The invention provides a kind of Noninvasive blood sugar monitoring system, have: gather saliva sample and obtain the saliva sugar concentration acquisition device (101) of the physics and chemistry signal in this saliva sample; Connect saliva sugar concentration acquisition device (101), according to this physics and chemistry signal, calculate current blood glucose value and this blood glucose value is associated with a plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in storage unit, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting with reference to blood glucose curve after, show blood glucose value, blood glucose curve and with reference to the processing host (102) of blood glucose curve; By cable network or wireless network, connect processing host (102), the blood glucose value that reception & disposal main frame (102) sends the remote monitoring center (103) that shows, stores.
Described processing host (102) can be connected by internet with remote monitoring center (103).
Described processing host (102) also can be connected by mobile communications network with remote monitoring center (103).
Described saliva sugar concentration acquisition device further has:
By polyurethane foam, be configured for gathering the sample collection portion (1) of saliva sample;
Be filled with lactochrome adenylic acid complexing glucose dehydrogenase, for the saliva sample that sample collection portion (1) is gathered, carry out the electrochemical reaction groove (2) of electrochemical reaction;
Be connected to electrochemical reaction groove (2) upper, for the electric current producing in electrochemical reaction groove (2) is transmitted to the electric signal transmission wire (3) on main frame;
Described sample collection portion (1) is fixed on electrochemical reaction groove (2);
Described electrochemical reaction groove (2) outside is provided with insulation course (201);
Described processing host further comprises:
The physics and chemistry signal that described saliva sugar concentration acquisition device is obtained is converted to the signal processing unit of electric signal;
Receive and process the electric signal that described signal processing unit sends, calculate the processor of current blood glucose value;
Be pre-stored with the patient's individual's blood glucose level data storehouse with blood sugar secure threshold, the storage unit of healthy blood glucose level data storehouse and diet database; And
Display unit with control with input function;
Described processor is presented at the blood glucose value of processing gained on display unit, a plurality of blood glucose values of the former period that this blood glucose value is recorded with individual blood glucose level data storehouse in storage unit are associated, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting is with reference to blood glucose curve, by described blood glucose value, blood glucose curve and being presented on display unit with reference to blood glucose curve upgrades the correlation parameter of each database in storage unit simultaneously;
In display unit, input food variety, feed quantity and eating time, processor is according to the contained sugar of the varieties of food items of recording in diet database, calculate total sugar content of feed, and according to the blood glucose value obtaining in meal time and above-mentioned steps, section compared and drew comprehensive glycemic index detection time, and this index is presented on display unit.
The lactochrome adenylic acid complexing glucose dehydrogenase of further, filling in described electrochemical reaction groove (2) is wrapped on glass nano microballoon.
Further, the lactochrome adenylic acid complexing glucose dehydrogenase in described electrochemical reaction groove (2) or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing glucose dehydrogenase are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Further, also comprise the threshold alerts unit (4) that whether reaches collection capacity for monitoring the saliva of sample collection portion (1) collection; Described threshold alerts unit (4) comprising: be set in sample collection portion (1) around, the humidity sensor (401) that the humidity of sample collection portion (1) is detected;
Connect humidity sensor (401), the humidity value that humidity sensor (401) is detected compares with the threshold value of setting, and sends the single-chip microcomputer (402) of alerting signal after humidity value reaches setting threshold;
Connect single-chip microcomputer (402), the alerting signal that single-chip microcomputer (402) is sent is carried out corresponding alarm unit (403);
Be connected on the loop that humidity sensor (401), single-chip microcomputer (402) and alarm unit (403) form, to the unlatching of circuit or close the switch (404) of controlling.
Further also have: alarm unit (9), in described individual blood glucose level data storehouse, be set with the normal range threshold value of comprehensive glycemic index, when processor (7) detects described glycemic index and exceeds threshold value, in the upper display alarm information of display unit (8), control alarm unit (9) simultaneously and report to the police.
The stationary installation further also with fixing saliva sugar concentration acquisition device (101) and processing host (102), this stationary installation is elastoplast, the joint of this bandage is provided with velcro.
The positive correlation of Noninvasive blood sugar monitoring system provided by the invention based on saliva sugar concentration and blood sugar concentration, from measuring saliva sugar concentration, start with, indirect determination blood sugar concentration, now for the existing instrument based on Woundless blood sugar monitoring technology, have easy and simple to handle, be easy to carry, the advantage such as measurement result degree of accuracy is high and instrument stabilizer is good.
Accompanying drawing explanation
Fig. 1 is the structural drawing of Noninvasive blood sugar monitoring system provided by the invention;
Fig. 2 is the structural drawing of saliva sugar concentration acquisition device in Fig. 1;
Fig. 3 is the further structural drawing of saliva sugar concentration acquisition device in Fig. 1.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearer, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein, only in order to explain the present invention, is not intended to limit the present invention.
As shown in Figure 1, Noninvasive blood sugar monitoring system provided by the invention comprises: gather saliva sample and obtain the saliva sugar concentration acquisition device 101 of the physics and chemistry signal in this saliva sample; Connect saliva sugar concentration acquisition device 101, according to this physics and chemistry signal, calculate current blood glucose value and this blood glucose value is associated with a plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in storage unit, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting with reference to blood glucose curve after, show blood glucose value, blood glucose curve and with reference to the processing host 102 of blood glucose curve; By cable network or wireless network, connect processing host 102, the blood glucose value that reception & disposal main frame 102 sends the remote monitoring center 103 that shows, stores.
Cable network wherein can be internet, and wireless network wherein can be mobile communications network or other electric communication network, and this mobile communications network is preferably GPRS network.
In addition, this system also comprises the stationary installation of fixing saliva sugar concentration acquisition device 101 and processing host 102, and this stationary installation is elastoplast, and the joint of this bandage is provided with velcro.
As shown in Figure 2, saliva sugar concentration acquisition device 101 comprises: the sample collection portion 1 that is configured for gathering saliva sample by polyurethane foam; Be filled with lactochrome adenylic acid complexing glucose dehydrogenase, for the saliva sample that sample collection portion 1 is gathered, carry out the electrochemical reaction groove 2 of electrochemical reaction; Be connected on electrochemical reaction groove 2, for the electric current of electrochemical reaction groove 2 interior generations is transmitted to the electric signal transmission wire 3 on main frame; Sample collection portion 1 is fixed on electrochemical reaction groove 2; Electrochemical reaction groove 2 outsides are provided with insulation course 201.
Wherein, the lactochrome adenylic acid complexing glucose dehydrogenase of electrochemical reaction groove 2 interior fillings is wrapped on glass nano microballoon.
Wherein, the lactochrome adenylic acid complexing glucose dehydrogenase in electrochemical reaction groove 2 or the glass nano microballoon that is enclosed with lactochrome adenylic acid complexing glucose dehydrogenase are dissolved in the phosphate-buffered saline damping fluid of pH value 7.4.
Shown in Fig. 2 and Fig. 3, saliva sugar concentration acquisition device 101 also comprises the threshold alerts unit 4 that whether reaches collection capacity for monitoring the saliva of sample collection portion 1 collection; Described threshold alerts unit 4 comprises: be set in around sample collection portion 1 humidity sensor 401 that the humidity of sample collection portion 1 is detected; Connect humidity sensor 401, the humidity value that humidity sensor 401 is detected compares with the threshold value of setting, and sends the single-chip microcomputer 402 of alerting signal after humidity value reaches setting threshold; Connect single-chip microcomputer 402, the alerting signal that single-chip microcomputer 402 is sent is carried out corresponding alarm unit 403; Be connected on the loop that humidity sensor 401, single-chip microcomputer 402 and alarm unit 403 form, to the unlatching of circuit or close the switch 404 of controlling.
Further, processing host 102 comprises: the physics and chemistry signal that saliva sugar concentration acquisition device 101 is obtained is converted to the signal processing unit of electric signal; Receive and process the electric signal that described signal processing unit sends, calculate the processor of current blood glucose value; Be pre-stored with the patient's individual's blood glucose level data storehouse with blood sugar secure threshold, the storage unit of healthy blood glucose level data storehouse and diet database; And with the display unit of controlling with input function; Processor is presented at the blood glucose value of processing gained on display unit, a plurality of blood glucose values of the former period that this blood glucose value is recorded with individual blood glucose level data storehouse in storage unit are associated, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting is with reference to blood glucose curve, by described blood glucose value, blood glucose curve and being presented on display unit with reference to blood glucose curve upgrades the correlation parameter of each database in storage unit simultaneously; In display unit, input food variety, feed quantity and eating time, processor is according to the contained sugar of the varieties of food items of recording in diet database, calculate total sugar content of feed, and according to the blood glucose value obtaining in meal time and above-mentioned steps, section compared and drew comprehensive glycemic index detection time, and this index is presented on display unit;
Further, processing host 102 also comprises: the alarm unit that connects processor, in individual's blood glucose level data storehouse, be set with the normal range threshold value of comprehensive glycemic index, when processor detects described glycemic index and exceeds threshold value, display alarm information on display unit, controls alarm unit simultaneously and reports to the police.
The positive correlation of Noninvasive blood sugar monitoring system provided by the invention based on saliva sugar concentration and blood sugar concentration, from measuring saliva sugar concentration, start with, indirect determination blood sugar concentration, now for the existing instrument based on Woundless blood sugar monitoring technology, have easy and simple to handle, be easy to carry, the advantage such as measurement result degree of accuracy is high and instrument stabilizer is good.
The above; it is only preferably embodiment of the present invention; but protection scope of the present invention is not limited to this; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; according to technical scheme of the present invention and inventive concept thereof, be equal to replacement or changed, within all should being encompassed in protection scope of the present invention.
Claims (8)
1. a Noninvasive blood sugar monitoring system, is characterized in that having:
Gather saliva sample and obtain the saliva sugar concentration acquisition device (101) of the physics and chemistry signal in this saliva sample;
Connect saliva sugar concentration acquisition device (101), according to this physics and chemistry signal, calculate current blood glucose value and this blood glucose value is associated with a plurality of blood glucose values of the former period of individual blood glucose level data storehouse record in storage unit, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting with reference to blood glucose curve after, show blood glucose value, blood glucose curve and with reference to the processing host (102) of blood glucose curve;
By cable network or wireless network, connect processing host (102), the blood glucose value that reception & disposal main frame (102) sends the remote monitoring center (103) that shows, stores;
Described saliva sugar concentration acquisition device has:
By polyurethane foam, be configured for gathering the sample collection portion (1) of saliva sample;
Be filled with lactochrome adenylic acid complexing glucose dehydrogenase, for the saliva sample that sample collection portion (1) is gathered, carry out the electrochemical reaction groove (2) of electrochemical reaction;
Be connected to electrochemical reaction groove (2) upper, for the electric current producing in electrochemical reaction groove (2) is transmitted to the electric signal transmission wire (3) on main frame;
Described sample collection portion (1) is fixed on electrochemical reaction groove (2);
Described electrochemical reaction groove (2) outside is provided with insulation course (201);
Described processing host comprises:
The physics and chemistry signal that described saliva sugar concentration acquisition device is obtained is converted to the signal processing unit of electric signal;
Receive and process the electric signal that described signal processing unit sends, calculate the processor of current blood glucose value;
Be pre-stored with the patient's individual's blood glucose level data storehouse with blood sugar secure threshold, the storage unit of healthy blood glucose level data storehouse and diet database; And
Display unit with control with input function;
Described processor is presented at the blood glucose value of processing gained on display unit, a plurality of blood glucose values of the former period that this blood glucose value is recorded with individual blood glucose level data storehouse in storage unit are associated, draw individual blood glucose curve, simultaneous processor calls the blood glucose level data of corresponding period in healthy blood glucose level data storehouse, drafting is with reference to blood glucose curve, by described blood glucose value, blood glucose curve and being presented on display unit with reference to blood glucose curve upgrades the correlation parameter of each database in storage unit simultaneously;
In display unit, input food variety, feed quantity and eating time, processor is according to the contained sugar of the varieties of food items of recording in diet database, calculate total sugar content of feed, and according to the blood glucose value obtaining in meal time and above-mentioned steps, section compared and drew comprehensive glycemic index detection time, and this index is presented on display unit.
2. Noninvasive blood sugar monitoring system as claimed in claim 1, is characterized in that described processing host (102) is connected by internet with remote monitoring center (103).
3. Noninvasive blood sugar monitoring system as claimed in claim 1, is characterized in that described processing host (102) is connected by mobile communications network with remote monitoring center (103).
4. Noninvasive blood sugar monitoring system as claimed in claim 1, is characterized in that the lactochrome adenylic acid complexing glucose dehydrogenase of filling in described electrochemical reaction groove (2) is wrapped on glass nano microballoon.
5. the Noninvasive blood sugar monitoring system as described in claim 1 or 4, the glass nano microballoon that it is characterized in that the lactochrome adenylic acid complexing glucose dehydrogenase in described electrochemical reaction groove (2) or be enclosed with lactochrome adenylic acid complexing glucose dehydrogenase is dissolved in the phosphate buffer of pH value 7.4.
6. Noninvasive blood sugar monitoring system as claimed in claim 1, characterized by further comprising the threshold alerts unit (4) that whether reaches collection capacity for monitoring the saliva of sample collection portion (1) collection; Described threshold alerts unit (4) comprising: be set in sample collection portion (1) around, the humidity sensor (401) that the humidity of sample collection portion (1) is detected;
Connect humidity sensor (401), the humidity value that humidity sensor (401) is detected compares with the threshold value of setting, and sends the single-chip microcomputer (402) of alerting signal after humidity value reaches setting threshold;
Connect single-chip microcomputer (402), the alerting signal that single-chip microcomputer (402) is sent is carried out first alarm unit (403) of corresponding warning;
Be connected on the loop that humidity sensor (401), single-chip microcomputer (402) and the first alarm unit (403) form, to the unlatching of circuit or close the switch (404) of controlling.
7. Noninvasive blood sugar monitoring system as claimed in claim 1, it is characterized in that also having: the second alarm unit, in described individual blood glucose level data storehouse, be set with the normal range threshold value of comprehensive glycemic index, when processor detects described glycemic index and exceeds threshold value, display alarm information on display unit, controls the second alarm unit simultaneously and reports to the police.
8. Noninvasive blood sugar monitoring system as claimed in claim 1, is characterized in that also having the fixedly stationary installation of saliva sugar concentration acquisition device (101) and processing host (102), and this stationary installation is elastoplast, and the joint of this bandage is provided with velcro.
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| CN201110234260.1A CN102323310B (en) | 2011-08-16 | 2011-08-16 | Noninvasive blood sugar monitoring system |
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| CN201110234260.1A CN102323310B (en) | 2011-08-16 | 2011-08-16 | Noninvasive blood sugar monitoring system |
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| CN102323310B true CN102323310B (en) | 2014-03-12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103499621A (en) * | 2013-10-22 | 2014-01-08 | 文加斌 | Noninvasive blood glucose monitor |
| RU2598344C2 (en) * | 2014-04-25 | 2016-09-20 | Тахир Хусанович Холматов | Conductometric method for non-invasive blood sugar measurement, device for implementation of the conductometric method with non-invasive measurement of blood sugar |
| KR102335739B1 (en) * | 2014-12-19 | 2021-12-06 | 삼성전자주식회사 | Apparatus and method for measuring a blood glucose in a noninvasive manner |
| KR101883412B1 (en) * | 2016-12-21 | 2018-07-30 | 주식회사 동운아나텍 | Device for diagnosing using saliva and analyzing method using the same |
| CN107951492A (en) * | 2017-11-16 | 2018-04-24 | 天津大学 | A kind of noninvasive dynamics monitoring device |
| CN110873751A (en) * | 2018-08-31 | 2020-03-10 | 佛山市顺德区美的电热电器制造有限公司 | Purine sensor and purine uptake control method |
| CN109682873A (en) | 2019-01-25 | 2019-04-26 | 京东方科技集团股份有限公司 | A kind of saliva detection device and system |
| CN111820955B (en) * | 2020-07-27 | 2021-09-10 | 南方科技大学 | Intelligent device is gathered to portable pharynx swab |
| CN113171090B (en) * | 2021-03-12 | 2023-09-26 | 中山大学 | Diabetes monitoring and treatment device and system based on mesoporous microneedle |
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| CN1300025A (en) * | 1999-12-10 | 2001-06-20 | 北京通路科技责任有限公司 | Non-injurious salivary blood sugar instrument |
| CN100342825C (en) * | 2005-11-28 | 2007-10-17 | 何宗彦 | Non-wound rapid blood sugar detecting method and its detecting instrument |
| CN101762707A (en) * | 2010-01-05 | 2010-06-30 | 深圳市西可德信通信技术设备有限公司 | Mobile blood sugar detection method and system |
| CN202204794U (en) * | 2011-08-16 | 2012-04-25 | 苏州悦安医疗电子有限公司 | Noninvasive glucose monitoring system |
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