CN210933423U - Regulation and control focusing device for magnetic nanoparticles - Google Patents
Regulation and control focusing device for magnetic nanoparticles Download PDFInfo
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- CN210933423U CN210933423U CN201920815137.0U CN201920815137U CN210933423U CN 210933423 U CN210933423 U CN 210933423U CN 201920815137 U CN201920815137 U CN 201920815137U CN 210933423 U CN210933423 U CN 210933423U
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Abstract
The utility model discloses a regulation and control focusing device of magnetic nanoparticles, be equipped with the magnetic field system, this magnetic field system includes two at least coil pairs, the coil pair includes two sets of polarized coil groups and two promotion coils, polarized coil group includes two sub-coils, two sub-coils are parallel to setting up, and the direction of winding is the same, form one-way polarization area between two sub-coils of the same group, be parallel to each other between the sub-coils of two polarized coil groups of the same pair, the direction of winding of wire is opposite, two one-way polarization areas of the same pair have alternately each other, form two-way polarization area; the central lines of the two pushing coils are collinear, are vertical to the coil ring and are respectively positioned at two sides of the corresponding bidirectional polarization area; the two-way polarization regions of different pairs of coil pairs cross each other to form magnetic regulatory regions. Adopt the beneficial effects of the utility model are that, to the ascending polarization coil assembly in all directions and promote the coil circular telegram in order to promote magnetic particle in proper order, highly controllable realizes the gathering of magnetic particle.
Description
Technical Field
The utility model relates to a control field of magnetic particle material, concretely relates to regulation and control focusing device of magnetic nanoparticle.
Background
Magnetic particles, especially nano magnetic particles, are novel materials which are developed rapidly and have high application value in recent years, and are widely applied in various fields of modern science, such as biomedicine, magnetofluid, catalysis, nuclear magnetic resonance imaging, data storage, environmental protection and the like. The nano magnetic particles generally consist of metals such as iron, cobalt, nickel and the like and oxides thereof, are generally in a core-shell structure in the medical field, and consist of a magnetic core and a high polymer/silicon/hydroxyapatite shell layer wrapped outside the magnetic core. The most common core layer is made of Fe with superparamagnetic or ferromagnetic properties3O4Or gamma-Fe2O3The prepared magnetic particle has magnetic guidance, which means that the magnetic particle has targeting property in the magnetic field environment. Under the action of an external magnetic field, the magnetic particles can move in a directional mode, and the target area is conveniently located and targeted.
After the magnetic particles carry the medicine, the medicine can be well gathered at a target position under the magnetic regulation and control action, and the medicine is helpful for realizing important technical breakthrough in the treatment of some current serious diseases, such as tumor treatment and the like. However, under the prior art, the magnetic particles are difficult to gather at the deep position of the body under the action of the magnetic field and can only gather at the superficial tissues. Thus, the diffusion of the drug through the blood circulation in normal tissues other than the target site causes drug side effects, particularly, drugs having potent efficacy such as anticancer drugs, which also have a killing effect on normal tissue cells. The key to solve this problem is how to control the accurate arrival of the drug at the lesion and the accurate release of the drug. Although the existing targeting technology including magnetic targeting technology has been developed rapidly, how to achieve deep targeting still faces significant technical challenges and is also an international research hotspot, and the international top journal has reports on magnetic regulation technology in the last two years. Despite some advances in research, the application of magnetic modulation techniques to clinical trials has faced technical challenges. Under human physiological conditions, the motion state of magnetic particles is very complex, so basic research needs to be verified under in vitro conditions by a simplified model. The problem to be solved is how to develop a magnetic regulation device and a method for highly controllable magnetic particles in a simplified in vitro environment.
SUMMERY OF THE UTILITY MODEL
In order to solve the above technical problems, one of the objectives of the present invention is to provide a focusing device for controlling magnetic nanoparticles.
The technical scheme is as follows:
the key point of the device for regulating and focusing the magnetic nanoparticles is that the device comprises a magnetic field system;
the magnetic field system comprises at least two pairs of coil pairs, one pair of the coil pairs comprises two groups of polarized coil groups, and one group of the polarized coil groups comprises two sub-coils;
the two sub-coils in the same group are arranged in parallel and opposite to each other, the winding directions of the leads are the same, and a unidirectional polarization area is formed between the two sub-coils in the same group;
the sub-coils of the two polarized coil groups of the same pair are parallel to each other, the winding directions of the leads of the two polarized coil groups of the same pair are opposite, and the unidirectional polarized areas of the two polarized coil groups of the same pair are crossed with each other to form a bidirectional polarized area;
the pair of coils further comprises two pushing coils, the center lines of the pushing coils are parallel to the center lines of the sub-coils in the same pair, the center lines of the two pushing coils are located on the same straight line, the two pushing coils are located on two sides corresponding to the bidirectional polarization areas respectively, and the inner ends of the two pushing coils face the corresponding bidirectional polarization areas respectively;
the sub-coils of the coil pairs of different pairs form an included angle with each other;
the two-way polarization regions of different pairs of the coil pairs cross each other to form magnetic regulatory regions.
By adopting the design, magnetic particles are placed in the magnetic regulation and control area, a certain polarization coil group is electrified to polarize the magnetic particles, then the pushing coil matched with the magnetic regulation and control area is electrified, the direction of the magnetic field of the pushing coil in the magnetic regulation and control area is consistent with the direction of the magnetic field of the polarization coil group, the repulsive force of the pushing coil to the magnetic particles pushes the polarized magnetic particles to gather to the central plane of the magnetic regulation and control area, thus, two groups of polarization coil groups in each coil pair are electrified in sequence, the magnetic particles are gradually pushed to gather from the corresponding direction to the center of the magnetic regulation and control area, and the device can highly controllably realize the gathering of the magnetic particles.
Preferably, the central lines of the sub-coils of the two polarized coil groups of the same pair are overlapped.
By adopting the design, the overlapping degree of the polarization areas of the two polarization coil groups is higher, so that the area of polarizability is larger.
As a preferred technical scheme, two sub-coils of the same group are formed by winding the same polarized wire in the same direction, the middle section of the polarized wire is perpendicular to the two corresponding sub-coils, and the two ends of the middle section of the polarized wire are respectively connected with the sub-coils with the same winding number;
the two sub-coils of the same group and the two sub-coils of the other group in the same pair are mutually wrapped;
the unidirectional polarization regions of two of the polarized coil sets of the same pair overlap so that the bidirectional polarization region and the unidirectional polarization region coincide.
Design more than adopting, two internal polarizing coil group of a coil are around establishing together for the regional coincidence completely of polarization of the two compares two coil group dislocation set, the utility model discloses a polarizing coil group's wire is around establishing the regional high coincidence in magnetic field that the mode can make between two polarizing coil group, thereby provides the biggest effective magnetic field region, especially under the situation that has the multiunit coil pair, the effective space maximize in whole magnetic regulation and control district.
As a preferred technical scheme, the central line of the pushing coil is superposed with the central lines of the sub-coils in the same pair to form a regulating central line;
the central lines of all the push coils intersect at the center of the magnetic regulation area.
By adopting the design, the pushing force of the magnetic particles placed in the magnetic control area on the central line direction of each coil pair is uniform, so that the movement stability of the magnetic particles is facilitated, the aggregation process of the magnetic particles is well controlled, and the final aggregation degree is improved.
As a preferred technical scheme, the sub-coil is a square coil, and the side length of the square coil is L;
the distance between two sub-coils in the same group is D;
D＝L/2。
by adopting the design, the distance between the two coil rings ensures that the magnetic field in the unidirectional polarization area is similar to a uniform magnetic field, so that the magnetic particles dispersed in the magnetic regulation area are subjected to the same polarization magnetic field.
As a preferable technical scheme, the pushing coil is a solenoid, the radius of the pushing coil is recorded as r, the distance from the inner end surface of the pushing coil to the center of the magnetic regulation area is d,
by adopting the design, according to the magnetic field distribution characteristics of the electrified solenoid, under the condition of meeting the distance parameters, the magnetic field intensity of the electrified solenoid at the center of the magnetic regulation area tends to zero, so that the situation that magnetic particles cross the center of the magnetic regulation area along one direction in the process of pushing the magnetic particles to move can be avoided, the situation that the magnetic particles on the other side of the center of the magnetic regulation area move to the edge of the magnetic regulation area due to the pushing force can be avoided, and the magnetic particles are sequentially pushed in each direction, so that all the magnetic particles can be highly gathered at the center of the magnetic regulation area.
As a preferred technical scheme, all the coil pairs are uniformly distributed around the central ring direction of the magnetic regulation and control area in the same plane.
By adopting the design, the magnetic particles can be gathered to the center of the magnetic control area by sequentially applying the driving force in each direction in the plane of the central lines of all the coil pairs.
As a preferred technical scheme, the two groups of coil pairs are provided, and the regulating central lines of the two groups of coil pairs are vertical to each other.
By adopting the design, the aggregation of the magnetic particles in the plane can be completed by pushing the two straight lines in the plane in four directions, and the device has a simple structure.
As a preferred technical scheme, all the coil pairs are divergently distributed in a three-dimensional space by the center of the magnetic regulation area.
By adopting the design, the driving force is sequentially applied in all directions, and the magnetic particles dispersed in the three-dimensional space can be gathered to the center of the magnetic control area.
As a preferred technical scheme, the coil pairs have three groups, the regulating central lines of the three groups of coil pairs are mutually vertical, and the regulating central lines of the three groups of coil pairs are orthogonal to the center of the magnetic regulating area.
By adopting the design, the aggregation of the magnetic particles in the three-dimensional space can be completed by pushing the magnetic particles in six directions of three orthogonal straight lines in the space, and the device has a simple structure.
Has the advantages that: adopt the beneficial effects of the utility model are that, to the internal polarization coil assembly of each coil and promote the coil circular telegram in proper order, promote magnetic particle gradually and gather towards the center of magnetism regulation and control district from corresponding direction, the device can highly controllable realize magnetic particle's gathering.
Drawings
FIG. 1 is a schematic structural diagram according to a first embodiment;
FIG. 2 is a top view of FIG. 1;
FIG. 3 is a schematic diagram of a coil pair;
FIG. 4 is a schematic structural diagram of the second embodiment;
FIG. 5 is a process for regulating the aggregation of magnetic particles in a plane by the method of example three or four, showing the movement of magnetic particles during one energization period;
FIG. 6 is the energization parameters for one energization of one polarization-driving coil set in the fifth embodiment;
FIG. 7 is a video screenshot showing the process of aggregating magnetic particles according to the fifth embodiment;
FIG. 8 is a photograph of manipulation of aggregated magnetic particles to move within a magnetically controlled region by varying a control parameter.
Detailed Description
The present invention will be further explained with reference to the following examples and drawings.
As shown in fig. 1 to 4, a device for controlling focusing of magnetic nanoparticles includes a magnetic field system;
the magnetic field system comprises at least two pairs of coil pairs 100, wherein one pair of coil pairs 100 comprises two groups of polarized coil groups, and one group of polarized coil groups comprises two sub-coils;
the two sub-coils in the same group are arranged in parallel and opposite to each other, and the winding directions of the wires are the same; a unidirectional polarization area is formed between the two sub-coils in the same group;
the sub-coils of the two polarized coil groups of the same pair are parallel to each other, the winding directions of the leads of the two polarized coil groups of the same pair are opposite, and the unidirectional polarized areas of the two polarized coil groups of the same pair are crossed with each other to form a bidirectional polarized area;
the pair of coils 100 further includes two pushing coils 120, the center lines of the pushing coils 120 are parallel to the center lines of the sub-coils in the same pair, the center lines of the two pushing coils 120 are located on the same straight line, the two pushing coils 120 are respectively located at two sides corresponding to the bidirectional polarization regions, and the inner ends of the two pushing coils 120 respectively face the corresponding bidirectional polarization regions;
the sub-coils of the coil pairs 100 of different pairs have an included angle with each other;
the bi-directional polarization regions of different pairs of the coil pairs 100 cross each other to form a magnetic steering region 130.
The central lines of the sub-coils of the two polarized coil groups of the same pair are superposed.
In order to enable the polarized magnetic field in the polarized area between the two sub-coils in the same group to be a uniform magnetic field and enable magnetic field force on magnetic particles in the area to be consistent, the two sub-coils in the same group are formed by winding the same polarized wire in the same direction, the middle section of the polarized wire is perpendicular to the two corresponding sub-coils, and the two ends of the middle section of the polarized wire are respectively connected with the sub-coils with the same winding number.
The two sub-coils of the same group and the two sub-coils of the other group in the same pair are mutually wrapped, namely the sub-coils of the two polarized coil groups of the same pair are respectively wound together. In this way, the unidirectional polarization regions of two of the polarized coil sets of the same pair overlap, so that the bidirectional polarization region and the unidirectional polarization region coincide.
The central line of the push coil 120 coincides with the central lines of the sub-coils in the same pair to form a regulation central line, and the central lines of all the push coils 120 intersect at the center of the magnetic regulation region 130.
In order to facilitate the installation of each coil of the magnetic field system, a winding mold shell is further arranged, all the sub-coils are respectively wound on the winding mold shell, and the push coil 120 is fixed on the winding mold shell. Specifically, the winding mold shell is a casing with a regular polyhedral shape, a pair of opposite surfaces parallel to the winding mold shell are wound with the same pair of two polarized coil sets, and the two opposite surfaces are respectively and fixedly provided with the push coils 120. The winding mold shell can be made of high molecular materials so as not to interfere the internal magnetic field.
The sub-coils are square coils, the side length of each sub-coil is L, the distance between two sub-coils in the same group is D, and D is L/2.
Thus, when a polarized coil assembly is energized, the magnetic field distribution between the two sub-coils is approximately uniform. The push coil 120 is a solenoid having a radius r, a distance d from an inner end surface of the push coil 120 to a center of the corresponding bi-directional polarization region, and a relationship between d and r
The two groups of polarized coil groups of the pair of coil pairs 100 are opposite in winding direction, and after the same voltage is applied, the directions of the magnetic fields of the two groups of polarized coil groups in the bidirectional polarized region are opposite, so as to polarize the magnetic particles, and the two corresponding push coils 120 are respectively matched with the two groups of polarized coil groups, so as to push the magnetic particles to move.
For convenience of description, a set of cooperating polarized coils and push coils 120 is referred to as a one-directional polarized-push coil set. The following is a specific application form of the present invention.
Example one
Figures 1 and 2 illustrate a planar regulated focusing device. There are two pairs of the coil pairs 100, and the center lines of the two pairs of the coil pairs 100 are perpendicular. The inside is equipped with the wire winding mould shell of cubic form, and the polarized coil group is all around establishing on this wire winding mould shell, and promotion coil 120 wears to establish on the face of corresponding wire winding mould shell. For convenience, the central lines of the two sets of coil pairs 100 are respectively marked as an x axis and a y axis, and then two polarization-pushing coil sets with opposite pushing directions are respectively arranged on the x axis and the y axis. The four pushing directions of the pushing coils are sequentially marked as an X + pushing coil group, an X-pushing coil group, a Y + pushing coil group and a Y-pushing coil group. The X + polarized coil group and the X + pushing coil form an X + polarized-pushing coil group, and the rest are analogized in this way, namely an X-polarized-pushing coil group, a Y + polarized-pushing coil group and a Y-polarized-pushing coil group.
The magnetic field system of this first embodiment can be used for the controlled aggregation of magnetic particles dispersed in the xy plane.
Example two
Figure 4 shows a three-dimensional regulated aggregation device. Three coil pairs 100 are provided, three coil pairs 100 enclose the magnetic control region 130 in a cubic shape, and the center lines of three coil pairs 100 are orthogonal to the center of the magnetic control region 130. The inside is equipped with square shaped's cavity wire winding mould shell, and the polarized coil group is all around establishing on this wire winding mould shell, and the promotion coil 120 is worn to establish on the face of corresponding wire winding mould shell.
For convenience, the center lines of the three coil pairs 100 are respectively marked as an x axis, a y axis and a z axis, and then two polarization-push coil sets with opposite push directions are respectively arranged on the x axis, the y axis and the z axis. The six pushing directions of the pushing coils are sequentially marked as an X + pushing coil group, an X-polarizing coil group, a Y + polarizing coil group, a Y-polarizing coil group, a Z + polarizing coil group and a Z-polarizing coil group. After combination, an X + polarization-pushing coil group, an X-polarization-pushing coil group, a Y + polarization-pushing coil group, a Y-polarization-pushing coil group, a Z + polarization-pushing coil group and a Z-polarization-pushing coil group are formed in sequence.
The coil pair 100 in the first and second embodiments will be described in detail by taking the X-axis direction as an example:
the coil pair 100 in the X-axis direction includes a forward polarized coil group a and a reverse polarized coil group B;
the forward polarized coil group A comprises two sub-coils, namely a sub-coil A1 and a sub-coil A2; the sub-coil A1 and the sub-coil A2 are arranged in parallel and opposite to each other, the winding directions of the wires are the same, and a unidirectional polarization area A is formed between the sub-coil A1 and the sub-coil A2;
the reverse polarization coil group B comprises two sub-coils, namely a sub-coil B1 and a sub-coil B2; the sub-coil B1 and the sub-coil B2 are arranged in parallel and opposite to each other, and the winding directions of the wires are the same; a unidirectional polarization area B is formed between the sub-coil B1 and the sub-coil B2;
the winding turns of the sub-coil A1, the sub-coil A2, the sub-coil B1 and the sub-coil B2 are the same, and the center lines of the sub-coil A1, the sub-coil A2, the sub-coil B1 and the sub-coil B2 are overlapped;
the two sub-coils of the forward polarized coil group A and the two sub-coils of the reverse polarized coil group B are parallel to each other, and the wire winding directions of the forward polarized coil group A and the reverse polarized coil group B are opposite;
the sub-coil A1 and the sub-coil A2 are formed by winding the same polarization lead A in the same direction, the middle section of the polarization lead A is perpendicular to the sub-coil A1 and the sub-coil A2, and the two ends of the middle section of the polarization lead A are respectively connected with the sub-coil A1 and the sub-coil A2;
the sub-coil B1 and the sub-coil B2 are formed by winding the same polarized lead B in the same direction, the middle section of the polarized lead B is perpendicular to the sub-coil B1 and the sub-coil B2, and the two ends of the middle section of the polarized lead B are respectively connected with the sub-coil B1 and the sub-coil B2;
the polarized conducting wire A and the polarized conducting wire B are enameled wires;
the sub-coil A1 and the sub-coil B1 are wrapped to form a first annular wire harness 110 in an integrated mode, and the sub-coil A2 and the sub-coil B2 are wrapped to form another annular wire harness 110 in an integrated mode;
the unidirectional polarization area A and the unidirectional polarization area B are overlapped to form a bidirectional polarization area;
the coil pair 100 in the X direction further includes two push coils 120, which are an X + direction push coil and an X-direction push coil, respectively, wherein the X + direction push coil and the first annular beam 110 are located at the same side, and the X-direction push coil and the second annular beam 110 are located at the same side.
EXAMPLE III
A method for regulating and aggregating magnetic particles comprises the following steps,
placing the dispersed magnetic particles into a magnetic regulatory region 130 of a magnetic field system;
electrifying the magnetic field system, wherein the electrifying rule of the magnetic field system is as follows: starting to electrify a group of polarization-pushing coil groups, powering off after a certain time, and then electrifying the next polarization-pushing coil group adjacent to the group of polarization-pushing coil groups, so that all the polarization-pushing coil groups are electrified in sequence respectively to form a polarization-pushing electrifying period;
the energization rule of each polarization-push coil set is that a voltage of U is applied to the polarization coil set of the polarization-push coil setjDuration of TjComplete the polarization of the magnetic particles, with a time interval△T applies a voltage U to the push coil 120 of the coil assemblytDuration of Tt(ii) a Pushing the magnetic particles to approach to the surface perpendicular to the central line of the pushing coil 120 and passing through the center of the magnetic control region;
the polarization promotion energization cycle is repeated according to the energization timing and voltage to form a rotating magnetic field, which gradually promotes the magnetic particles to be gathered toward the center of the magnetic regulation region 130 from all directions in sequence.
Specifically, the energization process of the magnetic field system in the first embodiment is as follows: firstly, sequentially electrifying the X + polarized coil group and the X + push coil; then electrifying the Y + polarized coil group and the Y + pushing coil in sequence; then electrifying the X-polarized coil group and the X-pushing coil in sequence; and finally, sequentially electrifying the Y-polarized coil group and the Y-push coil to complete an electrifying period. It is also possible to energize against this sequence.
Fig. 5 illustrates the process of regulating the aggregation of magnetic particles in a plane, showing the state of motion of the magnetic particles during a power-on cycle. The distribution state of the magnetic particles in the initial state is shown as a in fig. 5, after the operation is started, firstly, the X + coil group is electrified to generate magnetic force, and the magnetic particles in the magnetic regulation region 130 close to the X + coil group are pushed to move to the middle part, after a period of time, the magnetic particles in the region are obviously gathered to the middle part, then, the X + coil group is powered off, and at the moment, the distribution state of the magnetic particles is shown as b in fig. 5, and the magnetic particles in the magnetic regulation region 130 close to the X + coil group move to the y axis; then, energizing the Y + coil group to generate magnetic force and push the magnetic particles in the magnetic regulation and control region 130 close to the Y + coil group to move and gather towards the middle part, after a period of time, the magnetic particles in the region gather towards the x axis obviously, and then, deenergizing the Y + coil group, wherein the distribution state of the magnetic particles is as shown in c in figure 5, and the magnetic particles in the region close to the Y + coil group gather at the x axis; then the X-coil group is electrified to generate magnetic force to push the magnetic particles in the magnetic control region 130 close to the X-coil group to move and gather towards the middle part, after a period of time, the magnetic particles in the region are obviously gathered at the middle part, then the X-coil group is powered off, and at the moment, the distribution state of the magnetic particles is shown as d in figure 5, and the magnetic particles in the region close to the X-coil group are gathered towards the y axis; then the Y-coil group is electrified to generate magnetic force and push the magnetic particles in the area close to the Y-coil group to move and gather towards the middle part, after a period of time, the magnetic particles in the area are gathered at the middle part obviously, then the Y-coil group is powered off, and the distribution state of the magnetic particles is shown as e in figure 5, and the magnetic particles are gathered towards the center of the magnetic regulation area obviously. After this is repeated many times, the magnetic particles may be all concentrated at the center of the magnetic regulatory region 130.
An example of the energization process of the magnetic field system in the second embodiment is: firstly, sequentially electrifying an X + polarized coil group and an X + pushing coil; secondly, sequentially electrifying the Y + polarized coil group and the Y + pushing coil; thirdly, electrifying the Z + polarized coil group and the Z + pushing coil in sequence; fourthly, successively electrifying the X-polarized coil group and the X-pushing coil; fifthly, electrifying the Y-polarized coil group and the Y-pushing coil in sequence; and sixthly, successively electrifying the Z-polarized coil group and the Z-pushing coil to complete an electrifying period. It will be appreciated by those skilled in the art that it is also possible to change the sequence of energization in each direction and complete energization in all directions in sequence within one energization cycle.
When three or more pairs of coil pairs are arranged in a plane or in a space, the unidirectional polarization-pushing groups in all directions are sequentially electrified according to the rule, the electrifying process is continuously changed, a multidirectional magnetic field which is rotationally changed in the plane or in the space is formed, magnetic particles are pushed from all directions, and the magnetic particles can be more finely regulated. It is anticipated that the greater the number of pairs of coils, the more precise the control of the movement of the magnetic particles.
Example four
The difference from the third embodiment is that each of the polarization-push coil sets is energized by applying a voltage U to the polarization coil set of the polarization-push coil setjhDuration of Tj1Then drop the voltage to UjDuration of Tj2And T isj1+Tj2＝Tj；
After a time interval△T, to the same said polarisationThe push coils 120 of the push coil set apply a voltage UthDuration of Tt1Then drop the voltage to UtDuration of Tt2And T ist1+Tt2＝Tt。
The reason for this is that the magnetic field strength of the coil, when energized, is a process that gradually increases and then stabilizes due to inductive impedance effects. First a high voltage is applied to the coil so that the magnetic field strength of the coil increases more quickly to the design value, and then a lower sustain voltage is applied. Compared with the method of applying constant maintaining voltage, the method can improve the responsiveness of the magnetic field system, so that the movement of the magnetic particles is more controllable.
EXAMPLE five
According to the method of the fourth embodiment, the validity of the present invention is verified. Take the magnetic field system of embodiment one as an example.
10 mg of 20-200 nm Fe3O4The magnetic particles were dispersed in 20ml of liquid and then placed in a glass vial 50mm in diameter, which was placed in the center of the magnetic field control zone. Setting the control parameters as follows:
as shown in FIG. 6, a voltage of U is applied to the polarized coil assemblyjh540V, duration T j15 mus and then dropping the voltage to Uj150V, duration T j2600 mus, interval time△T605 mu s, and applying a voltage U to the push coil 120 of the coil set 100th-800V, duration Tt140 mus and then dropping the voltage to Ut-120V, duration Tt2＝60μs。
In the experiment, the power supply is electrified at a frequency of 32Hz, the coil current is pushed to 120A, and the in-plane magnetic nanoparticles are gathered according to the method. The distribution condition of the magnetic particles in the glass bottle in the pushing process is recorded by using a video, a screenshot is selected according to time, as can be seen from fig. 7, the magnetic nanoparticles are uniformly distributed in a plane and continuously converge towards the central area along with the increase of the time, and when the instrument works for 180s, the magnetic nanoparticles are obviously converged at the central area.
EXAMPLE six
When the magnetic particles move in the liquid, the farther the magnetic particles are from a certain pushing coil, the smaller the pushing force is, and in addition, the resistance of the liquid and the friction force with the bottle bottom are also applied. Thus, by setting the current magnitude to obtain an appropriate magnetic field strength, the magnetic particles can be slowly, controllably, and gradually aggregated. Further, the magnetic particle clusters gathered can be moved along a specific route by changing the value of the applied voltage and the energization time, as shown in fig. 8, in which the magnetic particle clusters are in circles.
In the experiment, a power supply system is reasonably controlled to obtain a proper magnetic field, so that the magnetic nanoparticles continuously move forwards under the action of magnetic repulsion, and are continuously gathered in the center of a magnetic regulation area by being pushed in four plane directions. By changing the power-on parameters, the gathered magnetic nanoparticle clusters can also be moved or pushed to a target position along a specific route. The method and the device for gathering the magnetic particles can be applied to laboratory research in the field of biomedicine, such as targeted removal of deep tumor cells, and provide a foundation for more complex targeted treatment of drug-loaded magnetic particles closer to the environment of organism tissues.
Finally, it should be noted that the above description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and the scope of the present invention.
Claims (10)
1. A magnetic nanoparticle regulation and focusing device is characterized in that: comprises a magnetic field system;
the magnetic field system comprises at least two pairs of coil pairs (100), one pair of the coil pairs (100) comprises two groups of polarized coils, and one group of the polarized coils comprises two sub-coils;
the two sub-coils in the same group are arranged in parallel and opposite to each other, the winding directions of the leads are the same, and a unidirectional polarization area is formed between the two sub-coils in the same group;
the sub-coils of the two polarized coil groups of the same pair are parallel to each other, the winding directions of the leads of the two polarized coil groups of the same pair are opposite, and the unidirectional polarized areas of the two polarized coil groups of the same pair are crossed with each other to form a bidirectional polarized area;
the pair of coils (100) further comprises two pushing coils (120), the central lines of the pushing coils (120) are parallel to the central lines of the sub-coils in the same pair, the central lines of the two pushing coils (120) are located on the same straight line, the two pushing coils (120) are respectively located on two sides corresponding to the bidirectional polarization regions, and the inner ends of the two pushing coils (120) respectively face the corresponding bidirectional polarization regions;
sub-coils of the coil pairs (100) of different pairs mutually form an included angle;
the bi-directional polarized regions of different pairs of the coil pairs (100) cross each other to form a magnetic steering region (130).
2. A device for modulated focusing of magnetic nanoparticles as claimed in claim 1, characterized in that: the central lines of the sub-coils of the two polarized coil groups of the same pair are superposed.
3. A device for modulated focusing of magnetic nanoparticles as claimed in claim 2, characterized in that: the two sub-coils in the same group are formed by winding the same polarization lead in the same direction, the middle section of the polarization lead is perpendicular to the two corresponding sub-coils, and the two ends of the middle section of the polarization lead are respectively connected with the sub-coils with the same winding number;
the two sub-coils of the same group and the two sub-coils of the other group in the same pair are mutually wrapped;
the unidirectional polarization regions of two of the polarized coil sets of the same pair overlap so that the bidirectional polarization region and the unidirectional polarization region coincide.
4. A device for modulated focusing of magnetic nanoparticles according to claim 3, characterized in that: the central line of the pushing coil (120) is superposed with the central lines of the sub-coils in the same pair to form a regulating central line;
the center lines of all the push coils (120) intersect at the center of the magnetic regulation region (130).
5. A device for modulated focusing of magnetic nanoparticles as claimed in claim 1, characterized in that:
the sub-coils are square coils, and the side length of each sub-coil is L;
the distance between two sub-coils in the same group is D;
D＝L/2。
6. a device for modulated focusing of magnetic nanoparticles according to claim 1, 2, 3, 4 or 5, characterized in that: the pushing coil (120) is a solenoid, the radius of the pushing coil is r, the distance from the inner end surface of the pushing coil (120) to the center of the magnetic regulation area (130) is d,
7. a device for modulated focusing of magnetic nanoparticles according to claim 4, characterized in that: all the coil pairs (100) are uniformly distributed around the central ring direction of the magnetic regulation and control area (130) in the same plane.
8. A device for modulated focusing of magnetic nanoparticles according to claim 4 or 7, characterized in that: two pairs of the coil pairs (100) are provided, and the regulating central lines of the two pairs of the coil pairs (100) are mutually vertical.
9. A device for modulated focusing of magnetic nanoparticles according to claim 4, characterized in that: all the coil pairs (100) are distributed in a three-dimensional space with a central divergence of the magnetic control region (130).
10. A device for modulated focusing of magnetic nanoparticles according to claim 4 or 9, characterized in that: the coil pairs (100) are provided with three pairs, the regulating central lines of the three pairs of coil pairs (100) are mutually vertical, and the regulating central lines of the three pairs of coil pairs (100) are orthogonal to the center of the magnetic regulating area (130).
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| CN110064128A (en) * | 2019-05-31 | 2019-07-30 | 重庆科技学院 | A kind of regulation focusing device of magnetic nano particle |
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| CN110064128A (en) * | 2019-05-31 | 2019-07-30 | 重庆科技学院 | A kind of regulation focusing device of magnetic nano particle |
| CN110064128B (en) * | 2019-05-31 | 2023-09-22 | 重庆科技学院 | Magnetic nanoparticle's regulation and control focusing device |
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