CN110101967A - A kind of magnetic particle magnetic control aggregation apparatus - Google Patents
A kind of magnetic particle magnetic control aggregation apparatus Download PDFInfo
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- CN110101967A CN110101967A CN201910472757.3A CN201910472757A CN110101967A CN 110101967 A CN110101967 A CN 110101967A CN 201910472757 A CN201910472757 A CN 201910472757A CN 110101967 A CN110101967 A CN 110101967A
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- magnetic
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- magnetic particle
- subcoil
- field system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F7/00—Magnets
- H01F7/06—Electromagnets; Actuators including electromagnets
- H01F7/20—Electromagnets; Actuators including electromagnets without armatures
- H01F7/206—Electromagnets for lifting, handling or transporting of magnetic pieces or material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0272—Electro-active or magneto-active materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
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- Electromagnetism (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Power Engineering (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Magnetic Treatment Devices (AREA)
Abstract
The present invention discloses a kind of magnetic particle magnetic control aggregation apparatus, rotating mechanism including field system and for driving field system to rotate, field system includes polarizing coil and propelling coil, which includes the subcoil of two parallel face settings, and two sub- coil-windings are identical and are connected；A propelling coil is equipped with close to any one subcoil, the inner face of propelling coil is towards between two subcoils, rotating mechanism drives field system to rotate in the same plane around the midpoint of the line of centres of two subcoils, and the region that the rotational trajectory of field system surrounds forms magnetic tuning area.Using the beneficial effects of the invention are as follows, pass through polarization-pushing action, push to the magnetic particle of dispersion moves it to the middle part in magnetic tuning area, then field system rotates by a certain angle carries out polarizing-pushing again, repeat above-mentioned rotation-pushing action, assemble magnetic particle to the middle part in magnetic tuning area, the device is highly controllable to the movement of magnetic particle and Assembling Behavior.
Description
Technical field
The present invention relates to the control fields of magnetic-particle material, and in particular to a kind of magnetic particle magnetic control aggregation apparatus.
Background technique
Magnetic-particle especially nano magnetic particle is to quickly grow in recent years and the new material of great application value, existing
The various fields such as biological medicine, magnetic fluid, catalytic action, Magnetic resonance imaging, data storage and environmental protection etc. of generation science
It has been more and more widely used.Nano magnetic particle is generally made of the metals such as iron, cobalt, nickel and its oxide, in medical domain
In it typically is core-shell structures, by magnetic kernel and the high molecular polymer/silicon/hydroxyapatite shell being wrapped in outside magnetic kernel
Layer composition.The most common stratum nucleare is by the Fe with superparamagnetic or ferromagnetic property3O4Or γ-Fe2O3It is made, there is magnetic conductance tropism, meaning
Taste under magnetic field environment magnetic particle there is targeting.Magnetic particle directional movable under the action of an external magnetic field, facilitates positioning and target
To target area.
After magnetic particle carries drug, under magnetic tuning effect, it can be gathered in target location well, facilitate current
Major technological breakthrough, such as oncotherapy are realized in the treatment of major disease.However, these magnetic particles are difficult under the conditions of the prior art
Body core position is focused under magnetic fields, can only focus on superficial tissues.In this way, drug is removing mesh by blood circulation
Diffusion will generate the violent drug of drug side-effect, especially drug effect such as anticancer drug in normal tissue except mark position,
Its normal tissue cell also has lethal effect.Solve the problems, such as that this key is that how to control drug accurately arrives at lesion
The accurate release of place and drug.Although existing targeting technology includes that magnetic targeted technology has been rapidly developed, how to realize
Depth targeting still faces important technical challenge, and is also international research hot spot.Although research has made some progress, by magnetic tune
Control technology is applied to clinical test and is also faced with technological challenge.Under the conditions of Human Physiology, the motion state of magnetic particle is extremely complex, because
This basic research needs are verified under in vitro conditions with simplified model.First have to solve the problems, such as be, how in simplification
Vitro under, develop the magnetic tuning device and method of highly controllable magnetic particle.It further, is under planar condition
Magnetic particle regulating device and method.
Summary of the invention
In order to solve the above technical problems, one of the objects of the present invention is to provide a kind of magnetic particle magnetic control aggregation apparatus.
Technical solution is as follows:
A kind of magnetic particle magnetic control aggregation apparatus, it is critical that including field system；
The field system includes for carrying out polarized polarizing coil to magnetic particle and for pushing magnetic particle to move
Propelling coil, the polarizing coil include the subcoil of two parallel face settings, and the direction of winding of two subcoils is identical；
Be equipped with a propelling coil close to any one of subcoil, the central axis of the propelling coil in
The subcoil plane, the inner face of the propelling coil is towards between two subcoils.
Using the above design, the magnetic particle of dispersion is placed between two subcoils, is powered to polarizing coil, two sub-lines
Magnetic field between circle is unidirectional magnetic field, and magnetic particle is made to polarize, and then polarizing coil powers off, and propelling coil is powered, propelling coil court
Repulsive force is generated to magnetic particle to one end of magnetic particle, to push magnetic particle along the repulsive force direction far from propelling coil
Inner face, it is mobile to two sub- thiols, in actual use, using the more set field systems arranged along multiple directions, or
Field system is set to turn over certain angle, multiple directions repeat aforementioned energization pushing course in space, magnetic particle aggregation can be arrived
Together.
As optimal technical scheme, above-mentioned polarizing coil is square coil, its side length is L, two above-mentioned subcoils it
Between distance be D, D=L/2.
Using the above design, the distance between two subcoils are set so that Distribution of Magnetic Field is approximate in region between the two
In uniform magnetic field, so that the effect for the polarizing magnetic field that each magnetic-particle of position in the inner is subject to is consistent.
As optimal technical scheme, form polarized area between two subcoils, the center line of the propelling coil with
The center line of the subcoil is overlapped；
The propelling coil is solenoid, and radius r, the inner side end of the propelling coil is into the polarized area
The distance of the heart is d；
Using the above design, according to the characteristics of magnetic field distribution of energization solenoid it is found that in the item for meeting above-mentioned distance parameter
Under part, magnetic field strength of the energization solenoid at polarization district center goes to zero, thus can be to avoid in promotion magnetic-particle movement
Magnetic-particle crosses polarization district center along a direction in the process, and all directions successively push magnetic-particle, so that all magnetic
Property particle can with high aggregation polarization district center at.
As optimal technical scheme, above-mentioned propelling coil is set to the center of any subcoil.
Using the above design, the centerline collineation of solenoidal center line and propelling coil, when as needed in multiple sides
To when multiple field systems are arranged, the center of the polarized area of the field system of all directions is overlapped or field system turns
When dynamic, using the district center that polarizes as center of rotation, assemble convenient for magnetic particle to the center.
As optimal technical scheme, above-mentioned magnetic control aggregation apparatus further includes winding bobbin, and the outer coiling of the winding bobbin is
Subcoil is stated, the propelling coil is arranged on the winding bobbin, and the propelling coil is fixed with the winding bobbin.
Using the above design, the installation convenient for each coil is fixed.
As optimal technical scheme, two subcoils are formed by same root polarization conducting wire coiling in the same direction, which leads
For the interlude of line perpendicular to the subcoil, it is identical described that the both ends of the polarization conducting wire interlude are connected separately with winding turns
Subcoil.
As optimal technical scheme, electric current when energization in two subcoils is equal, so that the magnetic field of polarized area remains
Uniform magnetic field.
The utility model has the advantages that using the invention has the advantages that the magnetic particle of dispersion is placed between two subcoils, to pole
Changing coil energization makes magnetic particle polarize, and then polarizing coil powers off, and propelling coil is powered, and propelling coil is towards one end of magnetic particle
Generate repulsive force to magnetic particle actually makes so that magnetic particle be pushed to move along the repulsive force direction to two sub- thiols
Used time using the more set field systems arranged along multiple directions, or makes field system turn over certain angle, multiple in space
Direction repeats aforementioned energization pushing course, forms rotating excitation field, continuous polarization and promotion magnetic particle, can be by magnetic particle aggregation to one
It rises, so as to realize the highly controllable of movement to magnetic particle and Assembling Behavior.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of field system；
Fig. 2 is the left view of Fig. 1；
Fig. 3 is that field system is wound on the schematic diagram on winding bobbin；
Fig. 4 is that field system rotates the schematic diagram to form magnetic tuning area；
Fig. 5 is the action schematic diagram that field system rotated and carried out to magnetic particle polarization promotion；
Fig. 6 is magnetic particle aggregation status diagram corresponding with the field system position of Fig. 5；
Fig. 7 is the structural schematic diagram for being provided with the magnetic control aggregation apparatus of rotating mechanism.
Specific embodiment
Below with reference to embodiment and attached drawing, the invention will be further described.
As illustrated in fig. 1 and 2, a kind of magnetic particle magnetic control aggregation apparatus, including field system 100, the field system 100 include
Propelling coil 120 for carrying out polarized polarizing coil 110 to magnetic particle and for pushing magnetic particle to move, the polarizing coil
110 include the subcoil 111 of two parallel face settings, and the direction of winding of two subcoils 111 is identical, two sons
Polarized area is formed between coil 111.
It is equipped with a propelling coil 120 close to any one of subcoil 111, in the propelling coil 120
Heart line is perpendicular to 111 plane of subcoil, and the inner face of the propelling coil 120 is towards between two subcoils 111.
The polarizing coil 110 is square coil, and its side length is L, the distance between two described subcoils 111 are D,
D=L/2.Under the distance, according to characteristics of magnetic field distribution, the magnetic field between two subcoils 111 after energization be may be considered
Uniform magnetic field.
Further, two subcoils 111 are formed by same root polarization conducting wire coiling in the same direction, in the polarization conducting wire
Between section perpendicular to the subcoil 111, the both ends of the polarization conducting wire interlude are connected separately with the identical son of winding turns
Coil 111.
The propelling coil 120 is solenoid, is placed in any one subcoil 111 in the solenoid, the two center line weight
It closes.The solenoidal radius is r, and the distance of the inner side end of the propelling coil 120 to the polarization district center is denoted as d, d and
The relationship of r is
Since the end face apart from energization solenoid is remoter, magnetic field strength is gradually decreased, the energization helical at the district center that polarizes
The field strength of pipe is close to zero.
As shown in figure 3, the magnetic control aggregation apparatus is provided with winding bobbin 400, the winding bobbin 400 for convenience of installing
It is wound with the subcoil 111 outside, the propelling coil 120 is arranged on the winding bobbin 400, the propelling coil 120
It is fixed with the winding bobbin 400.Specifically, the winding bobbin 400 is the shell that shape is in cuboid, is parallel to the shell
Two opposite flanks of body are arranged with the subcoil 111, are vertically equipped on any one face in the two opposite flanks
The propelling coil 120.High molecular material can be used to manufacture for winding bobbin 400, and is subject to and does not interfere internal magnetic field.
Field system is connected with power-supply system and control system, which controls power-supply system and supply to field system
Electricity.Under operative scenario, field system needs the center rotating around polarized area, thus in a plurality of directions to being dispersed in polarized area
Magnetic particle pushed.As shown in figure 4, the track of the inner face of propelling coil 120 is enclosed when the field system 100 rotates
At region and polarized area rotation process in the equitant part in the region turned over form magnetic tuning area 130.
Magnetic particle regulating accumulation process is as follows: firstly, magnetic tuning area 130 is dispersed by magnetic particle, then first to polarization line
Circle 110 is powered, voltage Ujh, duration Tj1, voltage is then reduced to Uj, duration Tj2；After interval time△T,
Apply voltage U to the propelling coil 120th, duration Tt1, voltage is then reduced to Ut, duration Tt2, with
First side pushes up magnetic particle.Since there are magneto-impedance effects for coil, when causing to be initially powered, magnetic field strength be one by
The cumulative big process then to tend towards stability.Apply high voltage to coil first, so that the magnetic field strength of coil quickly increases to
Then design value applies lower maintenance voltage again.Compared to the way for applying constant maintenance voltage, this method be can be improved
The responsiveness of field system, so that the movement of magnetic-particle is more controllable.
Next, field system 100 turns over certain angle, above-mentioned energization-pushing course is then carried out again.It repeats to turn
The process of dynamic-promotion, field system 100 rotate a circle, and complete an energization and push the period.Fig. 5 illustrate field system 100 by
According to being rotated clockwise, 90 ° of position view is turned over every time, completes a power cycles through four rotations.Fig. 6 is to correspond to
An energization push the period in magnetic particle aggregation process schematic.
The present embodiment provides a kind of and mating setting of field system 100 rotating mechanism 200, to realize field system 100
Controllable rotating, the rotating mechanism 200 is for driving the field system 100 to revolve in the same plane around the center of polarized area
Turn.
As shown in fig. 7, the rotating mechanism 200 includes rack 240, which includes pedestal 241 and is installed in the bottom
Portal frame 242 on seat 241.
Driving motor 230 is installed on the crossbeam of the portal frame 242, the output shaft of the driving motor 230, which is connected with, to be turned
Axis 220, the shaft 220 is vertically arranged, and lower end is connected with rotating turret 210.The rotating turret 210 rotates in horizontal plane, should
Fixed setting is equipped with the winding bobbin 400 and field system 100 below rotating turret 210, and the axial line of the shaft 220 passes through institute
State the center in magnetic tuning area 130.Driving motor is stepper motor.400 lower surface of winding bobbin is equipped with to be entered for sample
Sample well.
It is provided with liftable sample stage 300 below the field system 100, which passes through described
Sample well passes in and out the magnetic tuning area 130.
When carrying out magnetic particle regulating focusing experiment, first disperse magnetic particle in the vial for containing liquid, then by it
It is put on liftable sample stage 300, the height for adjusting liftable sample stage 300 makes vial be located at magnetic tuning area 130.Then magnetic
Field system 100 is powered on, and completes primary polarization-pushing course.Next, rotating mechanism 200 rotates, make field system 100
Certain angle is turned over, completes primary push again according to above-mentioned energization timing and voltage swing.
It repeats above-mentioned energization and pushes the period, rotating excitation field, continuous polarization and promotion magnetic particle are formed, until magnetic particle is larger
At the center for gathering to degree magnetic tuning region 130.The angle that field system 100 turns over every time is smaller, then completes one and lead to
The number that electricity pushes the period to be pushed is more, just more fine to the regulation accumulation process of magnetic particle.
This research, to obtain magnetic field appropriate, realizes magnetic nano particle in magnetic repulsion by rationally control power-supply system
It constantly travels forward under effect, by the promotion of all directions in plane, magnetic nano particle is constantly focused on into magnetic tuning region
Center.Such method and apparatus for focusing magnetic particle can be applied to field of biomedicine laboratory research, such as deep tumor cell
Targeting removal, the targeted therapy for the load medicine magnetic particle under more complicated, closer bio-tissue environment provides basis.
Finally, it should be noted that foregoing description is only the preferred embodiment of the present invention, the ordinary skill people of this field
Member under the inspiration of the present invention, without prejudice to the purpose of the present invention and the claims, can make multiple similar tables
Show, such transformation is fallen within the scope of protection of the present invention.
Claims (6)
1. a kind of magnetic particle magnetic control aggregation apparatus, it is characterised in that: including field system (100)；
The field system (100) includes for carrying out polarized polarizing coil (110) to magnetic particle and for pushing magnetic particle
The propelling coil (120) of movement, which includes the subcoil (111) of two parallel face settings, described in two
The direction of winding of subcoil (111) is identical；
It is equipped with a propelling coil (120) close to any one of subcoil (111), the propelling coil (120)
Central axis is in the subcoil (111) plane, inner face two subcoils of direction of the propelling coil (120)
(111) between.
2. a kind of magnetic particle magnetic control aggregation apparatus according to claim 1, it is characterised in that:
The polarizing coil (110) is square coil, and its side length is L；
The distance between two described subcoils (111) are D, D=L/2.
3. a kind of magnetic particle magnetic control aggregation apparatus according to claim 1 or 2, it is characterised in that:
Polarized area, the center line and the subcoil of the propelling coil (120) are formed between two subcoils (111)
(111) center line is overlapped；
The propelling coil (120) is solenoid, radius r, the inner side end of the propelling coil (120) to the polarization
The distance at the center in area is d；
4. a kind of magnetic particle magnetic control aggregation apparatus according to claim 1, it is characterised in that: the propelling coil (120)
It is set to the center of any subcoil (111).
5. a kind of magnetic particle magnetic control aggregation apparatus according to claim 4, it is characterised in that: further include winding bobbin
(400), it is wound with the subcoil (111) outside the winding bobbin (400), the propelling coil (120) is arranged in the coiling
On skeleton (400), the propelling coil (120) and the winding bobbin (400) are fixed.
6. a kind of magnetic particle magnetic control aggregation apparatus according to claim 1,2,4 or 5, it is characterised in that: two sons
Coil (111) is formed by same root polarization conducting wire coiling in the same direction, and the interlude of the polarization conducting wire is perpendicular to the subcoil
(111), the both ends of the polarization conducting wire interlude are connected separately with the identical subcoil (111) of winding turns.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910472757.3A CN110101967A (en) | 2019-05-31 | 2019-05-31 | A kind of magnetic particle magnetic control aggregation apparatus |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910472757.3A CN110101967A (en) | 2019-05-31 | 2019-05-31 | A kind of magnetic particle magnetic control aggregation apparatus |
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| CN110101967A true CN110101967A (en) | 2019-08-09 |
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| CN201910472757.3A Pending CN110101967A (en) | 2019-05-31 | 2019-05-31 | A kind of magnetic particle magnetic control aggregation apparatus |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110127771A (en) * | 2019-05-31 | 2019-08-16 | 重庆科技学院 | The regulation method for congregating of ferroferric oxide nano granules |
| CN114376991A (en) * | 2022-02-18 | 2022-04-22 | 北京大学深圳医院 | Magnetic mesoporous silica nanosphere motion trajectory regulation method and drug delivery system |
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| CN102847477A (en) * | 2012-09-25 | 2013-01-02 | 中国科学院电工研究所 | Magnetic stirring device and stirring method thereof |
| CN106237915A (en) * | 2016-08-16 | 2016-12-21 | 闫维新 | A kind of magnetic bead actuation means based on permanent magnet |
| CN108744257A (en) * | 2018-03-30 | 2018-11-06 | 深圳海磁康科技有限责任公司 | Magnetic and medicated targeting method for congregating and magnet structure |
| CN210933422U (en) * | 2019-05-31 | 2020-07-07 | 重庆科技学院 | Magnetic particle magnetic control gathering device |
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2019
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Patent Citations (5)
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| CN201249110Y (en) * | 2008-08-22 | 2009-06-03 | 杭州博日科技有限公司 | Magnetic stirring device based on nanometer magnetic beads |
| CN102847477A (en) * | 2012-09-25 | 2013-01-02 | 中国科学院电工研究所 | Magnetic stirring device and stirring method thereof |
| CN106237915A (en) * | 2016-08-16 | 2016-12-21 | 闫维新 | A kind of magnetic bead actuation means based on permanent magnet |
| CN108744257A (en) * | 2018-03-30 | 2018-11-06 | 深圳海磁康科技有限责任公司 | Magnetic and medicated targeting method for congregating and magnet structure |
| CN210933422U (en) * | 2019-05-31 | 2020-07-07 | 重庆科技学院 | Magnetic particle magnetic control gathering device |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110127771A (en) * | 2019-05-31 | 2019-08-16 | 重庆科技学院 | The regulation method for congregating of ferroferric oxide nano granules |
| CN114376991A (en) * | 2022-02-18 | 2022-04-22 | 北京大学深圳医院 | Magnetic mesoporous silica nanosphere motion trajectory regulation method and drug delivery system |
| CN114376991B (en) * | 2022-02-18 | 2024-08-20 | 北京大学深圳医院 | Magnetic mesoporous silica nanosphere motion track regulation and control method and drug delivery system |
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