CN107320723A - Magnetic nano-particle method for congregating based on three-dimensional magnetic field - Google Patents
Magnetic nano-particle method for congregating based on three-dimensional magnetic field Download PDFInfo
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
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Abstract
The present invention provides a kind of magnetic nano-particle method for congregating based on three-dimensional magnetic field, is moved using three-dimensional magnetic field driving magnetic nano-particle along X-direction, Y direction, Z-direction, completes the aggregation of magnetic nano-particle；Magnetic nano-particle is driven when some direction of principal axis is moved using three-dimensional magnetic field, first, apply timing in the direction of principal axis and keep constant orientation magnetic field, magnetic nano-particle is magnetized, magnetic nano-particle, which is magnetized to form magnetic pole and overturn, matches timing holding constant orientation magnetic field；Then, after magnetic nano-particle successful match alignment magnetic field, revocation timing keeps constant orientation magnetic field, and in the direction of principal axis application pulsed magnetic field opposite with the pole orientation of magnetic nano-particle, using the principle of magnetic homopolar-repulsion, magnetic nano-particle is promoted to be moved along the direction of principal axis.It is combined using 3 D tropism magnetic field with pulsed magnetic field, to realize the aggregation to magnetic nano-particle, the depth localization of magnetic nano-particle can be realized.
Description
Technical field
The present invention relates to magnetic field aggregation technique field, more specifically, it is related to a kind of magnetic Nano based on three-dimensional magnetic field
Particle buildup method.
Background technology
The method of oncotherapy for a long time has surgical excision, chemotherapy and radiotherapy.Modus operandi is because can not be complete
Clear all cancer cell, easily causes cancer cell and spreads again, and adding most human organs can not regenerate once excision, make operation
Method limitation is big.Chemotherapy and radiotherapy have largely injured normal cell again while cancer cell is killed, and cause a lot
Side effect and complication.Human research has found：The nerve and blood vessel of tumor locus are undeveloped, are easily heated, cancer cell is added
Heat will be dead to more than 43 DEG C, and normal cell be heated to more than 48 DEG C also will not death, it is therefore optionally that cancer is thin
Born of the same parents are heated to 43 DEG C -48 DEG C, and it is a kind of effective ways for treating cancer of being free from side effects to be killed, and this method is called warm
Therapy.Heating has the methods such as microwave, ultrasonic wave, infrared ray, hot water, but these methods can only all be heated in vitro, it is difficult to human body
The tumour of depths is effectively heated, the also difficult control such as heated perimeter, degree, it is difficult to be practically applicable to clinical treatment.
At present, people's research applies extraneous alternating magnetic field in advance by ferrimagnet implantation tumour position, then in the external world,
In the presence of alternating magnetic field, the magnetic domain orientation in ferrimagnet also can alternately change with the direction in magnetic field.In rotation
During change, magnetic domain mutually collides friction and produces heat, heats tumor locus by this magnetic hysteresis heat, reaches its temperature
To 43 DEG C -48 DEG C, cancer cell is removed, and normal cell preserves from, this method homogeneous heating, convenient temperature control, safety can
Lean on, deep-seated tumors can be heated, but it is low in the presence for the treatment of cancer cell efficiency, eliminate the defect such as not thorough.Treatment tumour also has
A kind of method, is that cancer therapy drug is implanted directly into tumor locus, medicine is directly acted on tumour cell.
Either frictional heat treatment method or medicine implanted treatment method, the most important condition is by medicine or magnetic
Material gathers in body the position that any one needs to treat, in the prior art, using injection by medicine or magnetic material
It is injected directly at tumour, but this method is invasive, and inside tumor pressure is big, the medicine or magnetic material of injection
Easily spill.
The content of the invention
In view of the above problems, it is an object of the invention to provide a kind of magnetic nano-particle aggregation side based on three-dimensional magnetic field
Method, to solve how to realize the problem of medicine or magnetic material are assembled in vivo.
The magnetic nano-particle method for congregating based on three-dimensional magnetic field that the present invention is provided, is received using three-dimensional magnetic field driving magnetic
Rice corpuscles is moved along X-direction, Y direction, Z-direction, completes the aggregation of magnetic nano-particle；Wherein,
The process that magnetic nano-particle is moved in X-direction is driven using three-dimensional magnetic field, including：
Apply X axis timing in X-direction and keep constant orientation magnetic field, magnetic nano-particle is magnetized, magnetic is received
Rice corpuscles, which is magnetized to form magnetic pole and overturn matching X axis timing, keeps constant orientation magnetic field；
After the timing of magnetic nano-particle successful match X axis keeps constant orientation magnetic field, apply and magnetic in X-direction
The opposite X axis pulsed magnetic field of the pole orientation of nano-particle, promotes magnetic nano-particle to move in the X-axis direction；
The process that magnetic nano-particle is moved in Y direction is driven using three-dimensional magnetic field, including：
Apply Y-axis timing in Y direction and keep constant orientation magnetic field, magnetic nano-particle upset matching Y-axis timing
Keep constant orientation magnetic field；
After the timing of magnetic nano-particle successful match Y-axis keeps constant orientation magnetic field, apply and magnetic in Y direction
The opposite Y-axis pulsed magnetic field of the pole orientation of nano-particle, promotes magnetic nano-particle to be moved along Y direction；
The process that magnetic nano-particle is moved in Z-direction is driven using three-dimensional magnetic field, including：
Apply Z axis to timing holding constant orientation magnetic field in Z-direction, the magnetic nano-particle upset matching Z being magnetized
Axially timing keeps constant orientation magnetic field；
After magnetic nano-particle successful match Z axis keeps constant orientation magnetic field to timing, apply and magnetic in Z-direction
The opposite Z axis of the pole orientation of nano-particle promotes magnetic nano-particle to be moved along Z-direction to pulsed magnetic field.
Compared with prior art, the magnetic nano-particle method for congregating based on three-dimensional magnetic field that the present invention is provided, utilizes three
Dimension timing keeps constant orientation magnetic field to be combined with pulsed magnetic field, realizes and magnetic nano-particle aggregation in vivo and depth are determined
Position.
Brief description of the drawings
By reference to the explanation below in conjunction with accompanying drawing, and with the present invention is more fully understood, of the invention is other
Purpose and result will be more apparent and should be readily appreciated that.In the accompanying drawings：
Fig. 1 is the magnetic nano-particle according to the embodiment of the present invention in the first X axis timing holding constant orientation magnetic field
In view；
Fig. 2 is the magnetic nano-particle according to the embodiment of the present invention in second of X axis timing holding constant orientation magnetic field
In view；
Fig. 3 is the view in X axis pulsed magnetic field according to the magnetic nano-particle of the embodiment of the present invention；
Fig. 4 is the magnetic nano-particle according to the embodiment of the present invention in the first Y-axis timing holding constant orientation magnetic field
In view；
Fig. 5 is to be illustrated according to state of the magnetic nano-particle of the embodiment of the present invention in second of Y-axis pulsed magnetic field
Figure；
Fig. 6 is the view in Y-axis pulsed magnetic field according to the magnetic nano-particle of the embodiment of the present invention.
Embodiment
The specific embodiment of the present invention is described in detail below with reference to accompanying drawing.
The present invention provides a kind of magnetic nano-particle method for congregating based on three-dimensional magnetic field, and magnetic is driven using three-dimensional magnetic field
Nano-particle is moved in three-dimensional magnetic field along X-direction, Y direction, Z-direction, completes the aggregation of magnetic nano-particle, poly-
The position of the magnetic nano-particle gathered together reaches that the path of the objective can be different as objective, but finally
The position of arrival is identical, i.e. objective, that is to say, that the present invention is not necessarily non-according to X-direction → Y direction → Z
The permanent order driving magnetic nano-particle movement of direction of principal axis, X-direction → this order of Y direction → Z-direction is to arrive
Up to a paths of objective, and the other paths for reaching objective are as follows：
X-direction → Z-direction → Y direction；
Y direction → X-direction → Z-direction；
Y direction → Z-direction → X-direction；
Z-direction → X-direction → Y direction；
Z-direction → Y direction → X-direction.
It should be noted that magnetic nano-particle is driven not only in three-dimensional magnetic field but also in human body by three-dimensional magnetic field
Dynamic magnetic nano-particle motion, reaches the purpose that magnetic nano-particle is assembled in vivo, is mounted with and controls in magnetic nano-particle
Treat medicine, magnetic nano-particle as medicine carrier, play a part of transport medicine, the purpose of the present invention be as
Where the targeting aggregation of medicine is realized in vivo, and to replace existing injection system, therefore, the present invention is not a kind of to people
The treatment method of body disease.
The process that magnetic nano-particle is moved in X-direction is driven using three-dimensional magnetic field, including：
Step S11：Apply X axis timing in X-direction and keep constant orientation magnetic field, magnetic is carried out to magnetic nano-particle
Change, magnetic nano-particle, which is magnetized to form magnetic pole and overturn matching X axis timing, keeps constant orientation magnetic field.
The X axis timing applied in X-direction keeps the effect in constant orientation magnetic field to be, in magnetized magnetic nano-particle
While, prevent magnetic nano-particle from being moved towards some magnetic direction, magnetic nano-particle forms N poles and S poles after being magnetized, and
Constant orientation magnetic field is kept to match with X axis timing.
Producing X axis timing keeps the method in constant orientation magnetic field to have two kinds, two methods is carried out separately below detailed
Explanation.
First method：
As shown in figure 1, X axis timing keeps constant orientation magnetic field by two independent spaced multilaminate coiled poles
Change coil to produce, the winding number of turn of two polarizing coils is identical, magnetic nano-particle is located between two polarizing coils, polarize line
Circle is equivalent to solenoid, and two polarizing coils are filled with two magnetic fields of generation, the direction phase in two magnetic field after size identical electric current
It is identical with, magnetic field intensity, so that forming X axis timing keeps constant orientation magnetic field.It is identical big being filled with to two polarizing coils
After small electric current, according to Ampere's law, the left end of polarizing coil 1 is that S poles, right-hand member are N poles in Fig. 1, and the left end of polarizing coil 2 is
S poles, right-hand member are N poles, magnetic nano-particle 3 (in Fig. 1 exemplary show one) be located at the N poles of left side polarizing coil with it is right
Between the S poles of side polarizing coil, N poles and S poles, subsequent magnetic nano-particle 3 and X are produced after magnetic nano-particle 3 is magnetized
Axially timing keeps constant orientation magnetic field to be matched, and the S poles of magnetic nano-particle 3 are towards the N poles of polarizing coil 1, and magnetic is received
The N poles of rice corpuscles 3 are towards the S poles of polarizing coil 2, because the N poles of magnetic nano-particle 3 are attracted by the S poles of polarizing coil 1
Power, the N poles of magnetic nano-particle 3 are by the attraction of the S poles of polarizing coil 2, and therefore, magnetic nano-particle will not be towards polarization
Coil 1 or polarizing coil 2 are moved.
Two polarizing coils independently refer to that two polarizing coils are not connected in first method, are each filled with size phase
Deng, direction identical electric current.The magnetic direction that two polarizing coils are produced determines according to the direction of charging current, polarizing coil
Which end can be N poles or S poles, as long as ensureing to produce two magnetic fields in the same direction.
Second method：
As shown in Fig. 2 X axis timing keeps the polarization line that constant orientation magnetic field is arranged at intervals and linked together by two
Circle is produced, and polarizing coil is multilaminate coiled to be formed, and the winding number of turn of two polarizing coils is identical.Because two polarizing coils are connected,
Therefore, two coils are together charged, and the size of current being filled with is identical, and control is easy to compared to first method.By two poles
Change coil and regard a long polarizing coil as, magnetic nano-particle 3 is located at the inside of long polarizing coil, filled to two polarizing coils
Enter after electric current, the polarizing coil 1 in left side is used as the S poles of long polarizing coil, the long polarization line of the conduct of polarizing coil 2 on right side in Fig. 2
The N poles of circle, form X axis timing and keep constant orientation magnetic field, then the magnetic nano-particle 3 after magnetizing produces N poles and S poles, and
Matched with the pole orientation of long polarizing coil, finally, the S levels of magnetic nano-particle 3 are towards the S poles of long polarizing coil, and magnetic is received
The N levels of rice corpuscles 3 are towards the N poles of long polarizing coil.
Step S12：After the timing of magnetic nano-particle successful match X axis keeps constant orientation magnetic field, applied in X-direction
Plus the X axis pulsed magnetic field opposite with the pole orientation of magnetic nano-particle, promote magnetic nano-particle to move in the X-axis direction.
Because timing keeps constant orientation magnetic field magnetic nano-particle can not be driven to move, accordingly, it would be desirable to be applied in X-direction
Plus a pulsed magnetic field reverse with magnetic nanoparticle magnetic pole, to drive magnetic nano-particle to move.
Pulsed magnetic field is charged by pulsed coil to be produced, because pulsed magnetic field is a gradient magnetic field, when pulsed coil charging
When, to ensure that the magnetic nano-particle close to pulsed coil, by bigger magnetic force, has bigger displacement, promotes magnetic nano particle
Son is reunited.
As shown in figure 3, pulsed coil 4 is located at the left side of magnetic nano-particle 3, after pulsed coil 4 charges, pulsed coil
4 left end is that N poles, right-hand member are S poles, because the S of magnetic nano-particle 3 is extremely close to the S poles of pulsed coil 4, magnetic nano-particle 3
It can be moved right by the repulsive force of pulsed coil 4 along X axis.
When pulsed coil 4 is located at the right side of magnetic nano-particle 3, after the charging of pulsed coil 4, magnetic nano-particle 3
It can be moved left by the repulsive force of pulsed coil 4 along X axis.
It should be noted that magnetic nano-particle 3 by pulsed coil 4 repulsive force along X-direction move it is same
When can matching pulse magnetic field, i.e. magnetic nano-particle 3 start rotation while away from pulsed coil 4, with matching pulse coil 4
The direction of the pulsed magnetic field of generation, once the direction of magnetic nano-particle 3 and pulsed magnetic field matches, magnetic nano-particle 3 will
Not further away from pulsed coil 4, and start to be attracted by pulsed coil 4.Therefore, finally inverted in magnetic nano-particle 3 by impulse line
Before circle 4 attracts, there is the maximum duration of a pulsed magnetic field, the time cannot be greater than the upset of magnetic nano-particle 3
Duration, according to theoretical calculation, the shape of response time and particle of the magnetic nano-particle 3 in magnetic field, magnetic property and
Magnetic field size close relation, general scope is between 500 μ s and 100ms.
The process that magnetic nano-particle is moved in Y direction is driven using three-dimensional magnetic field, including：
Step S21：Apply Y-axis timing in Y direction and keep constant orientation magnetic field, the magnetic nano-particle being magnetized is turned over
Turn matching Y-axis timing and keep constant orientation magnetic field.
Applying Y-axis timing in Y direction keeps the method in constant orientation magnetic field to include two kinds, wherein,
First method：Y-axis timing keeps constant orientation magnetic field by being disposed on two independent poles of Y direction
Change coil charges to produce, magnetic nano-particle is located between two polarizing coils, and the magnetic nano-particle is the magnetic after magnetization
Property nano-particle, Y-axis pulsed magnetic field can be such that the magnetic nano-particle being magnetized is moved along Y direction.
Because magnetic nano-particle has been magnetized before being moved along X-direction, it is therefore not necessary to the magnetic nano-particle
Magnetize again, the magnetic nano-particle need to only overturn matching Y-axis timing and keep constant orientation magnetic field.
The winding number of turn of two polarizing coils of Y direction is identical, and the size of current being filled with is also identical, works as Y direction
The charging of two polarizing coils when, produce that two intensity are identical, direction identical magnetic field in Y direction, determine so as to form Y-axis
When keep constant orientation magnetic field, the magnetic nano-particle for keeping constant orientation magnetic field in Y-axis timing can the rotation matching Y-axis
Constant orientation magnetic field is kept to timing.
As shown in figure 4, after two of Y direction independent polarizing coils chargings, polarizing coil 1` upper end is S poles,
Lower end is N poles, and polarizing coil 2` upper end is that S poles, lower end are N poles, the magnetic nano-particle 3` rotate counterclockwises of X-direction
Constant orientation magnetic field is kept with Y-axis timing, postrotational magnetic nano-particle 3` S poles are revolved towards polarizing coil 2` N poles
The N poles of magnetic nano-particle 3` after turning are towards polarizing coil 1` S poles.
Because the intensity in the magnetic field of two polarizing coils generations is identical, therefore, processes of the magnetic nano-particle 3` in rotation
In will not produce displacement, i.e., will not be moved towards polarizing coil 1` or polarizing coil 2`.
Second method：As shown in figure 5, Y-axis timing keeps constant orientation magnetic field to be arranged at intervals and be connected to by two
Polarizing coil together is produced, and polarizing coil is multilaminate coiled to be formed, and the winding number of turn of two polarizing coils is identical.Due to two poles
Change coil to be connected, therefore, two coils together charge, and the size of current being filled with is identical, can regard two polarizing coils as one
Individual long polarizing coil, magnetic nano-particle 3` is located at the inside of long polarizing coil, after electric current is filled with to two polarizing coils, figure
The polarizing coil 2` of top is as the S poles of long polarizing coil in 5, and the polarizing coil 1` of lower section is used as the N poles of long polarizing coil, shape
Keep constant orientation magnetic field into Y-axis timing, then the magnetic nano-particle 3 after magnetizing produces N poles and S poles, and with long polarization line
The pole orientation matching of circle, finally, magnetic nano-particle 3` S levels are towards the S poles of long polarizing coil, the N of magnetic nano-particle 3
Level is towards the N poles of long polarizing coil.
Step S22：After the timing of magnetic nano-particle successful match Y-axis keeps constant orientation magnetic field, applied in Y direction
Plus the Y-axis pulsed magnetic field opposite with the pole orientation of magnetic nano-particle, promote magnetic nano-particle to be moved along Y direction.
Because timing keeps constant orientation magnetic field magnetic nano-particle can not be driven to move, accordingly, it would be desirable to be applied in Y direction
Plus a pulsed magnetic field reverse with postrotational magnetic nanoparticle magnetic pole, to drive magnetic nano-particle to be moved along Y direction
It is dynamic.
Pulsed magnetic field is charged by pulsed coil to be produced, because pulsed magnetic field is a gradient magnetic field, when pulsed coil charging
When, to ensure that the magnetic nano-particle close to pulsed coil, by bigger magnetic force, has bigger displacement, promotes magnetic nano particle
Son is reunited.
As shown in fig. 6, pulsed coil 4` is located at magnetic nano-particle 3` top, after pulsed coil 4` charges, pulse
Coil 4` lower end is that S poles, upper end are N poles, and because magnetic nano-particle 3` S is extremely close to pulsed coil 4` S poles, magnetic is received
Rice corpuscles 3` can be moved down by pulsed coil 4` repulsive force along Y-axis.
When pulsed coil 4` is located at magnetic nano-particle 3` lower section, after pulsed coil 4` chargings, magnetic nano particle
Sub- 3` can be moved up by pulsed coil 4` repulsive force along Y-axis.
The process that magnetic nano-particle is moved in Z-direction is driven using three-dimensional magnetic field, including：
Step S31：Apply Z axis to timing holding constant orientation magnetic field, magnetic nano-particle upset matching Z in Z-direction
Axially timing keeps constant orientation magnetic field.
The description that above-mentioned Y-axis timing keeps constant orientation magnetic field is refer to, Z axis keeps constant orientation magnetic field same to timing
Li Ke get.
Step S32：After magnetic nano-particle successful match Z axis keeps constant orientation magnetic field to timing, revocation Z axis is to calmly
When keep constant orientation magnetic field, and apply the Z axis opposite with the pole orientation of magnetic nano-particle to pulsed magnetic in Z-direction
, promote magnetic nano-particle to be moved along Z-direction.
The description of above-mentioned Y-axis pulsed magnetic field is refer to, Z axis can similarly be obtained to pulsed magnetic field.
The present invention sets two polarizing coils respectively in X-direction, Y direction and Z-direction, and six polarizing coils are from upper
Under, left and right, front and rear six direction magnetic nanoparticle is enclosed in centre, the space that six polarizing coils surround formation is three
Magnetic field space is tieed up, by accurately controlling X, Y, Z axis polarizing magnetic field, the direction of pulsed magnetic field and applying order, is followed through certain time
Ring processing, realizes the aggregation of the magnetic nano-particle in three dimensions.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (6)
1. a kind of magnetic nano-particle method for congregating based on three-dimensional magnetic field, magnetic nano-particle is driven along X using three-dimensional magnetic field
Direction of principal axis, Y direction, Z-direction motion, complete the aggregation of the magnetic nano-particle；Wherein,
The process that the magnetic nano-particle is moved in X-direction is driven using the three-dimensional magnetic field, including：
Apply X axis timing in X-direction and keep constant orientation magnetic field, the magnetic nano-particle is magnetized, the magnetic
Property nano-particle be magnetized to form magnetic pole and overturn matching X axis timing and keep constant orientation magnetic field；
After X axis timing keeps constant orientation magnetic field described in the magnetic nano-particle successful match, X-direction apply with
The opposite X axis pulsed magnetic field of the pole orientation of the magnetic nano-particle, promotes the magnetic nano-particle to be transported along X-direction
It is dynamic；
The process that the magnetic nano-particle is moved in Y direction is driven using the three-dimensional magnetic field, including：
Apply Y-axis timing in Y direction and keep constant orientation magnetic field, the magnetic nano-particle upset matching institute being magnetized
State Y-axis timing and keep constant orientation magnetic field；
After Y-axis timing keeps constant orientation magnetic field described in the magnetic nano-particle successful match, Y direction apply with
The opposite Y-axis pulsed magnetic field of the pole orientation of the magnetic nano-particle, promotes the magnetic nano-particle to be transported along Y direction
It is dynamic；
The process that the magnetic nano-particle is moved in Z-direction is driven using the three-dimensional magnetic field, including：
Apply Z axis to timing holding constant orientation magnetic field in Z-direction, the magnetic nano-particle upset matching institute being magnetized
State Z axis and keep constant orientation magnetic field to timing；
After Z axis described in the magnetic nano-particle successful match keeps constant orientation magnetic field to timing, Z-direction apply with
The opposite Z axis of the pole orientation of the magnetic nano-particle promotes the magnetic nano-particle to be transported along Z-direction to pulsed magnetic field
It is dynamic.
2. the magnetic nano-particle method for congregating as claimed in claim 1 based on three-dimensional magnetic field, wherein,
Applying the X axis timing keeps the process in constant orientation magnetic field to include：
By being powered to along two independent spaced polarizing coils of X-direction, generation both direction is identical, intensity is identical
Magnetic field, form X axis timing and keep constant orientation magnetic field；
Applying the Y-axis timing keeps the process in constant orientation magnetic field to include：
By being powered to along two spaced polarizing coils of Y direction, generation both direction is identical, intensity identical magnetic
, form the Y-axis timing and keep constant orientation magnetic field；
Apply the Z axis keeps the process in constant orientation magnetic field to include to timing：
By being powered to along two spaced polarizing coils of Z-direction, generation both direction is identical, intensity identical magnetic
, form the Z axis and keep constant orientation magnetic field to timing.
3. the magnetic nano-particle method for congregating as claimed in claim 1 based on three-dimensional magnetic field, wherein,
Applying the X axis timing keeps the process in constant orientation magnetic field to include：
By being connected and the energization of spaced polarizing coil to two along X-direction, produce the X axis timing and keep constant
Alignment magnetic field；
Applying the Y-axis timing keeps the process in constant orientation magnetic field to include：
By being connected and the energization of spaced polarizing coil to two along Y direction, produce the Y-axis timing and keep constant
Alignment magnetic field；
Apply the Z axis keeps the process in constant orientation magnetic field to include to timing：
By being connected and the energization of spaced polarizing coil to two along Z-direction, produce the Z axis and keep constant to timing
Alignment magnetic field.
4. the magnetic nano-particle method for congregating as claimed in claim 1 based on three-dimensional magnetic field, wherein,
The duration for applying the X axis pulsed magnetic field is overturn as the X axis pulsed magnetic less than the magnetic nano-particle
The time of field；
The duration for applying the Y-axis pulsed magnetic field is overturn as the X axis pulsed magnetic less than the magnetic nano-particle
The time of field；
It is the X axis pulsed magnetic to apply the Z axis to be less than magnetic nano-particle upset to the duration of pulsed magnetic field
The time of field.
5. the magnetic nano-particle method for congregating as claimed in claim 1 based on three-dimensional magnetic field, wherein,
Applying the process of the X axis pulsed magnetic field includes：
By being powered to the pulsed coil set along X-direction, produce opposite with the pole orientation of the magnetic nano-particle
The X axis pulsed magnetic field；
Applying the process of the Y-axis pulsed magnetic field includes：
By being powered to the pulsed coil set along Y direction, produce opposite with the pole orientation of the magnetic nano-particle
The Y-axis pulsed magnetic field；
Apply the Z axis includes to the process of pulsed magnetic field：
By being powered to the pulsed coil set along Z-direction, produce opposite with the pole orientation of the magnetic nano-particle
The Z axis is to pulsed magnetic field.
6. the magnetic nano-particle method for congregating as claimed in claim 1 based on three-dimensional magnetic field, wherein, driven using three-dimensional magnetic field
Dynamic magnetic nano-particle includes following several along the order that X-direction, Y direction, Z-direction are moved：
The first is sequentially followed successively by X-direction, Y direction, Z-direction；
Second of order is followed successively by X-direction, Z-direction, Y direction；
The third is sequentially followed successively by Y direction, X-direction, Z-direction；
4th kind of order is followed successively by Y direction, Z-direction, X-direction；
5th kind of order is followed successively by Z-direction, X-direction, Y direction；
6th kind of order is followed successively by Z-direction, Y direction, X-direction.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899622A (en) * | 2006-05-29 | 2007-01-24 | 上海大学 | Applying method for using magnetic field in magnetic particles |
| CN101983172A (en) * | 2008-02-28 | 2011-03-02 | 李欢成 | Unipolar magnetic carrier for 3d tumor targeting |
| CN102272312A (en) * | 2008-11-07 | 2011-12-07 | 智能纳米公司 | Transfection with magnetic nanoparticles and ultrasound |
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| CN103816578A (en) * | 2014-03-05 | 2014-05-28 | 广州一代医药科技有限公司 | Targeted drug delivery device for anti-tumor magnetic nanometer particle drug |
-
2017
- 2017-08-08 CN CN201710669547.4A patent/CN107320723A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1899622A (en) * | 2006-05-29 | 2007-01-24 | 上海大学 | Applying method for using magnetic field in magnetic particles |
| CN101983172A (en) * | 2008-02-28 | 2011-03-02 | 李欢成 | Unipolar magnetic carrier for 3d tumor targeting |
| CN102272312A (en) * | 2008-11-07 | 2011-12-07 | 智能纳米公司 | Transfection with magnetic nanoparticles and ultrasound |
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| CN103816578A (en) * | 2014-03-05 | 2014-05-28 | 广州一代医药科技有限公司 | Targeted drug delivery device for anti-tumor magnetic nanometer particle drug |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111524679A (en) * | 2019-02-01 | 2020-08-11 | 温伯格医学物理有限公司 | Method, system and component for selective magnetic particle movement |
| CN110085142A (en) * | 2019-05-15 | 2019-08-02 | 京东方科技集团股份有限公司 | Quantum dot light emitting structure, display panel, display device and its display methods |
| CN110085142B (en) * | 2019-05-15 | 2021-01-22 | 京东方科技集团股份有限公司 | Quantum dot light-emitting structure, display panel, display device and display method thereof |
| CN110064128A (en) * | 2019-05-31 | 2019-07-30 | 重庆科技学院 | A kind of regulation focusing device of magnetic nano particle |
| CN110127771A (en) * | 2019-05-31 | 2019-08-16 | 重庆科技学院 | The regulation method for congregating of ferroferric oxide nano granules |
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| CN110180076A (en) * | 2019-05-31 | 2019-08-30 | 重庆科技学院 | Magnetic particle regulating lens system in space |
| CN110176341B (en) * | 2019-05-31 | 2021-04-02 | 上海市第六人民医院 | Method for regulating and controlling aggregation of magnetic particles in space |
| CN110180076B (en) * | 2019-05-31 | 2022-03-01 | 重庆科技学院 | Spatial magnetic particle regulation and control aggregation system |
| CN110064128B (en) * | 2019-05-31 | 2023-09-22 | 重庆科技学院 | Magnetic nanoparticle's regulation and control focusing device |
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