CN110064128A - A kind of regulation focusing device of magnetic nano particle - Google Patents
A kind of regulation focusing device of magnetic nano particle Download PDFInfo
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- CN110064128A CN110064128A CN201910470804.0A CN201910470804A CN110064128A CN 110064128 A CN110064128 A CN 110064128A CN 201910470804 A CN201910470804 A CN 201910470804A CN 110064128 A CN110064128 A CN 110064128A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0272—Electro-active or magneto-active materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
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Abstract
The present invention discloses a kind of regulation focusing device of magnetic nano particle, equipped with field system, the field system includes at least two coils pair, coil is to including two groups of polarizing coil groups and two propelling coils, polarizing coil group includes two subcoils, the parallel face setting of two subcoils, and around to identical, unidirectional polarized area is formed between same group of two subcoils, it is parallel to each other between subcoil with two a pair of polarizing coil groups, conducting wire forms two-way polarized area around on the contrary, with two a pair of unidirectional polarized area mutuals intersections；The centerline collineation of two propelling coils, and it is vertical with coil loop, it is located at the two sides of corresponding two-way polarized area；The two-way polarized area mutual of different pairs of coil pair is intersected, to form magnetic tuning area.Using the invention has the advantages that gradually magnetic particle being pushed to move from corresponding direction to magnetic tuning district center successively to the polarizing coil group and propelling coil energization in all directions, realizing the aggregation of magnetic particle highly controllablely.
Description
Technical field
The present invention relates to the control fields of magnetic-particle material, and in particular to a kind of regulation focusing dress of magnetic nano particle
It sets.
Background technique
Magnetic-particle especially nano magnetic particle is to quickly grow in recent years and the new material of great application value, existing
The various fields such as biological medicine, magnetic fluid, catalytic action, Magnetic resonance imaging, data storage and environmental protection etc. of generation science
It has been more and more widely used.Nano magnetic particle is generally made of the metals such as iron, cobalt, nickel and its oxide, in medical domain
In it typically is core-shell structures, by magnetic kernel and the high molecular polymer/silicon/hydroxyapatite shell being wrapped in outside magnetic kernel
Layer composition.The most common stratum nucleare is by the Fe with superparamagnetic or ferromagnetic property3O4Or γ-Fe2O3It is made, there is magnetic conductance tropism, meaning
Taste under magnetic field environment magnetic particle there is targeting.Magnetic particle directional movable under the action of an external magnetic field, facilitates positioning and target
To target area.
After magnetic particle carries drug, under magnetic tuning effect, it can be gathered in target location well, facilitate current
Major technological breakthrough, such as oncotherapy are realized in the treatment of major disease.However, these magnetic particles are difficult under the conditions of the prior art
It is gathered in body core position under magnetic fields, superficial tissues can only be gathered in.In this way, drug is removing mesh by blood circulation
Diffusion will generate the violent drug of drug side-effect, especially drug effect such as anticancer drug in normal tissue except mark position,
Its normal tissue cell also has lethal effect.Solve the problems, such as that this key is that how to control drug accurately arrives at lesion
The accurate release of place and drug.Although existing targeting technology includes that magnetic targeted technology has been rapidly developed, how to realize
Depth targeting still faces important technical challenge, and is also international research hot spot, nearest 2 years international top periodicals about
The report of magnetic tuning technology.Although research has made some progress, magnetic tuning technology is applied to clinical test and is also faced with technology
Challenge.Under the conditions of Human Physiology, the motion state of magnetic particle is extremely complex, therefore basic research is needed with simplified model in body
It is verified under the conditions of outer.First have to solve the problems, such as be how under simplified vitro, to develop highly controllable magnetic
The magnetic tuning device and method of grain.
Summary of the invention
In order to solve the above technical problems, it focuses and fills one of the objects of the present invention is to provide a kind of regulation of magnetic nano particle
It sets.
Technical solution is as follows:
A kind of regulation focusing device of magnetic nano particle, it is critical that including field system；
The field system includes at least two pairs of coils pair, and a pair of coil is to including two groups of polarizing coil groups, and one group
The polarizing coil group includes two subcoils；
Same group of two subcoils are parallel, face setting, and conducting wire is around to identical, same group of two sons
Unidirectional polarized area is formed between coil；
It is parallel to each other between subcoil with two a pair of polarizing coil groups, with two a pair of polarization lines
The conducting wire of circle group is two-way to be formed around on the contrary, the unidirectional polarized area mutual with two a pair of polarizing coil groups is intersected
Polarized area；
A pair of coil is to further including two propelling coils, the center line of the propelling coil and same internally described
The center line of the centerline parallel of subcoil, two propelling coils is located along the same line, two propelling coils point
The two sides of the two-way polarized area Wei Yu not be corresponded to, the inner end of two propelling coils is respectively facing the corresponding two-way pole
Change area；
Mutual angle between the subcoil of the different pairs of coil pair；
The two-way polarized area mutual of the different pairs of coil pair is intersected, to form magnetic tuning area.
Using the above design, magnetic-particle is put into magnetic tuning area, is powered to some polarizing coil group to magnetism
Particle polarizes, and then matched propelling coil is powered, magnetic direction and pole of the propelling coil in magnetic tuning area
The magnetic direction for changing coil group is consistent, and propelling coil pushes polarized magnetic-particle to magnetic tuning area the repulsive force of magnetic-particle
Central plane aggregation, successively two group polarizing coil groups internal to each coil are powered in this way, gradually push magnetic-particle from
The center in corresponding direction towards magnetic tuning area is assembled, which can realize the aggregation of magnetic-particle highly controllablely.
As optimal technical scheme, the center line with the subcoil of two a pair of polarizing coil groups is overlapped.
Using the above design, so that the polarized area degree of overlapping of two polarizing coil groups is higher, so as to the area of polarization
Domain is larger.
As optimal technical scheme, same group of two subcoils are formed by same root polarization conducting wire coiling in the same direction,
The interlude of the polarization conducting wire is connected separately with perpendicular to corresponding two subcoils, the both ends of the polarization conducting wire interlude
The identical subcoil of winding turns；
Same group of two subcoils are mutually wrapped up with identical internal another group of two subcoils；
With the unidirectional polarization area overlapping of two a pair of polarizing coil groups, to make the two-way polarized area and unidirectional
Polarized area is overlapped.
Using the above design, two internal polarizing coil group windings of a coil together so that the polarized area of the two
Domain is completely coincident, and is compared two coil groups and is shifted to install, and the conducting wire winding mode of polarizing coil group of the invention can make two
Field region height between polarizing coil group is overlapped, to provide maximum effective magnetic field region, is especially having multiple groups line
To in the case of, the useful space in entire magnetic tuning area maximizes circle.
As optimal technical scheme, the center line weight of the center line of above-mentioned propelling coil and the same internal subcoil
It closes, forms regulation center line；
The center line of all propelling coils intersects at the center in the magnetic tuning area.
It is designed using above, what the magnetic-particle being put into magnetic tuning area was subject on the centerline direction of each coil pair
Motive force is more uniform, to be conducive to the stability of magnetic-particle movement, be conducive to preferably to control its accumulation process and
Improve final concentration class.
As optimal technical scheme, above-mentioned subcoil is square coil, and its side length is L；
The distance between same group two described subcoils are D；
D=L/2.
Using the above design, the distance between two coil loops guarantee that the magnetic field in unidirectional polarized area is similar to uniform magnetic
, so that the effect for the polarizing magnetic field that each magnetic-particle being dispersed in magnetic tuning region is subject to is consistent.
As optimal technical scheme, above-mentioned propelling coil is solenoid, and radius is denoted as r, the propelling coil inner face
Distance to the center in the magnetic tuning area is d,
Using the above design, according to the characteristics of magnetic field distribution of energization solenoid it is found that in the item for meeting above-mentioned distance parameter
Under part, magnetic field strength of the energization solenoid at magnetic tuning regional center goes to zero, thus can be to avoid in promotion magnetic-particle
Magnetic-particle crosses magnetic tuning regional center along a direction in motion process, and avoids the magnetic tuning regional center other side
Magnetic particle is mobile to magnetic tuning area edge by motive force, and all directions successively push magnetic-particle, so that being magnetic
Grain can be with high aggregation at magnetic tuning regional center.
As optimal technical scheme, all coils are circumferential to the center in the same plane around the magnetic tuning area
Even distribution.
Using the above design, in the plane where the center line in all coils pair, is successively applied by all directions and pushed away
Power, can be by magnetic particle aggregation to the center in magnetic tuning area.
As optimal technical scheme, for above-mentioned coil to there is two groups, the regulation center line of coil pair described in two groups is perpendicular.
Using the above design, by the promotion in plane on the four direction of two straight lines, magnetic-particle can be completed and exist
Aggregation in the plane, apparatus structure are simple.
As optimal technical scheme, all coils are distributed in three-dimensional space to the center diverging with the magnetic tuning area
It is interior.
Using the above design, successively applies motive force by all directions, the magnetism in three-dimensional space can be will be dispersed in
Center of the particle aggregation to magnetic tuning area.
As optimal technical scheme, to there is three groups, the regulation center line of coil pair described in three groups is mutually perpendicular to above-mentioned coil,
The regulation center line of three pairs of coils pair is orthogonal to the center in the magnetic tuning area.
It can be completed magnetic by the promotion in space on the six direction of three orthogonal straight lines using the above design
The aggregation of grain in three-dimensional space, apparatus structure are simple.
The utility model has the advantages that using the invention has the advantages that the successively polarizing coil group and promotion internal to each coil
Coil be powered, gradually push magnetic-particle from corresponding direction towards the center in magnetic tuning area assemble, the device can height can
Realize the aggregation of magnetic-particle in control ground.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of embodiment one；
Fig. 2 is the top view of Fig. 1；
Fig. 3 is the structural schematic diagram of coil pair；
Fig. 4 is the structural schematic diagram of embodiment two；
Fig. 5 is the process for planar regulating and controlling magnetic particle aggregation using the method for embodiment three or four, illustrates one in figure
The movement of magnetic particle in a power cycles；
Fig. 6 is in embodiment five to a polarization-propelling coil group once electrification electricity parameters；
Fig. 7 shows magnetic particle aggregation process in embodiment five by video interception mode；
Fig. 8 is by changing control parameter, the photo that the magnetic particle after manipulation aggregation moves in magnetic tuning area.
Specific embodiment
Below with reference to embodiment and attached drawing, the invention will be further described.
As shown in figures 1-4, the regulation focusing device of a kind of magnetic nano particle, including field system；
The field system includes at least two pairs of coils to 100, and a pair of coil includes two groups of polarizing coils to 100
Group, polarizing coil group described in one group include two subcoils；
Same group of two subcoils are parallel, face setting, and conducting wire is around to identical；Same group of two sons
Unidirectional polarized area is formed between coil；
It is parallel to each other between subcoil with two a pair of polarizing coil groups, with two a pair of polarization lines
The conducting wire of circle group is two-way to be formed around on the contrary, the unidirectional polarized area mutual with two a pair of polarizing coil groups is intersected
Polarized area；
A pair of coil further includes two propelling coils 120 to 100, the center line of the propelling coil 120 with it is same
The center line of the centerline parallel of the internal subcoil, two propelling coils 120 is located along the same line, two institutes
State the two sides that propelling coil 120 is located at the corresponding two-way polarized area, the inner end of two propelling coils 120 court respectively
To the corresponding two-way polarized area；
The different pairs of coil is to mutual angle between 100 subcoil；
The different pairs of coil intersects 100 two-way polarized area mutual, to form magnetic tuning area 130.
Center line with the subcoil of two a pair of polarizing coil groups is overlapped.
For the polarizing magnetic field uniform magnetic field for making the polarized area between same group of two subcoils, thus the area Shi Gai
The magnetic field force that magnetic particle in domain is subject to is consistent, same group of two subcoils conducting wire coiling in the same direction polarized by same root and
At perpendicular to corresponding two subcoils, the both ends of the polarization conducting wire interlude connect the interlude of the polarization conducting wire respectively
It is connected to the identical subcoil of winding turns.
Same group of two subcoils are mutually wrapped up with identical internal another group of two subcoils, Ye Jitong
The subcoil of two a pair of polarizing coil groups is wound into together respectively.In this way, with two a pair of polarizing coils
The unidirectional polarization area overlapping of group, so that the two-way polarized area and unidirectional polarized area be made to be overlapped.
The center line of the propelling coil 120 is overlapped with the center line of the same internal subcoil, is formed in regulation
The center line of heart line, all propelling coils 120 intersects at the center in the magnetic tuning area 130.
For convenience of the installation of each coil of the field system, it is additionally provided with coiling formwork, all subcoils point
It is not wound on the coiling formwork, the propelling coil 120 is fixed on the coiling formwork.Specifically, the winding former
Shell is the shell that shape is in regular polygon shape, and a pair of of the opposite face for being parallel to the coiling formwork is arranged with described in two of a pair
Polarizing coil group, upper in the two opposite faces are fixedly installed the propelling coil 120 respectively.Height can be used in coiling formwork
Molecular material manufacture, is subject to and does not interfere internal magnetic field.
The subcoil is square coil, and its side length is L, the distance between same group two described subcoils are D,
D=L/2.
In this way, the Distribution of Magnetic Field between two subcoil is approximately uniform after a polarizing coil group is powered.It is described
Propelling coil 120 is solenoid, radius r, the inner side end of the propelling coil 120 to the corresponding two-way polarized area
The distance at center is that the relationship of d, d and r are
A pair of coil to 100 two groups of polarizing coil groups around to after on the contrary, applying same voltage, the two is two-way
The magnetic direction of polarized area on the contrary, for polarizing to magnetic particle, corresponding two propelling coils 120 respectively with two groups
Polarizing coil group cooperation, for pushing magnetic particle to move.
It is convenient for statement, the polarization-that polarizing coil group and propelling coil 120 that one group matches are known as a direction is pushed away
Moving winding group.It is below concrete application form of the invention.
Embodiment one
Fig. 1 and 2 illustrates a kind of plane regulation aggregation apparatus.The coil has two pairs to 100, two pairs of coils pair
100 center line is perpendicular.Inside is equipped with the coiling formwork of cubic, and polarizing coil group is wound around on the coiling formwork,
Propelling coil 120 is threaded through on the face of corresponding coiling formwork.Convenient for statement, coil described in two groups divides 100 center line
It is not denoted as x-axis and y-axis, then is respectively equipped with the opposite polarization of two pushing directions-propelling coil group in x-axis and y-axis.Four are pushed away
The polarizing coil group in dynamic direction is successively denoted as X+ polarizing coil group, X- polarizing coil group, Y+ polarizing coil group and Y- polarizing coil
Group, the propelling coil of four pushing directions are successively denoted as X+ propelling coil, X- propelling coil, Y+ propelling coil and Y- and push line
Circle.X+ polarizing coil group and X+ propelling coil form X+ polarization-propelling coil group, and the rest may be inferred for remaining, and respectively X- polarizes-pushes away
Moving winding group, Y+ polarization-propelling coil group and Y- polarization-propelling coil group.
The regulation aggregation for the magnetic-particle that the field system of the embodiment one can be used for dispersing in x/y plane.
Embodiment two
Fig. 4 shows a kind of three-dimensional regulation aggregation apparatus.The coil has three groups to 100, and three groups of coils are surrounded to 100
The cube shaped magnetic tuning area 130, coil described in three groups are orthogonal in the magnetic tuning area 130 100 center line
The heart.Inside is equipped with hollow windings formwork square-shaped, and polarizing coil group is wound around on the coiling formwork, propelling coil 120
It is threaded through on the face of corresponding coiling formwork.
Convenient for statement, coil described in three groups is denoted as x-axis, y-axis and z-axis to 100 center line respectively, then x-axis, y-axis and z
The opposite polarization of two pushing directions-propelling coil group is respectively equipped on axis.Successively by the polarizing coil group of six pushing directions
It is denoted as X+ polarizing coil group, X- polarizing coil group, Y+ polarizing coil group, Y- polarizing coil group, Z+ polarizing coil group and Z- polarization
Coil group, the propelling coil of six pushing directions are successively denoted as X+ propelling coil, X- propelling coil, Y+ propelling coil, Y- and push
Coil, Z+ propelling coil and Z- propelling coil.After combination, X+ polarization-propelling coil group, X- polarization-propelling coil are successively formed
Group, Y+ polarization-propelling coil group, Y- polarization-propelling coil group, Z+ polarization-propelling coil group, Z- polarization-propelling coil group.
By taking X-direction as an example, the coil in embodiment one and embodiment two is described in detail to 100:
The coil of X axis includes forward direction polarizing coil group A and reverse polarization coil group B to 100；
The forward direction polarizing coil group A includes two subcoils, respectively subcoil A1 and subcoil A2；The subcoil
A1 is parallel with subcoil A2, face setting, and conducting wire forms unidirectional pole between the subcoil A1 and subcoil A2 around to identical
Change area A；
The reverse polarization coil group B includes two subcoils, respectively subcoil B1 and subcoil B2；The subcoil
B1 is parallel with subcoil B2, face setting, and conducting wire is around to identical；Unidirectional pole is formed between the subcoil B1 and subcoil B2
Change area B；
The subcoil A1, subcoil A2, subcoil B1 are identical with the winding turns of subcoil B2, the subcoil A1,
The center line coincidence of subcoil A2, subcoil B1, subcoil B2；
Between two subcoils of the forward direction polarizing coil group A and two subcoils of the reverse polarization coil group B
It is parallel to each other, the conducting wire of the forward direction polarizing coil group A and the reverse polarization coil group B is around to opposite；
The subcoil A1, subcoil A2 are formed by same root polarization conducting wire A coiling in the same direction, the centre of polarization conducting wire A
For section perpendicular to the subcoil A1 and subcoil A2, the both ends of the polarization conducting wire A interlude are connected separately with the subcoil A1
With subcoil A2；
The subcoil B1, subcoil B2 are formed by same root polarization conducting wire B coiling in the same direction, the centre of polarization conducting wire B
For section perpendicular to the subcoil B1 and subcoil B2, the both ends of the polarization conducting wire B interlude are connected separately with the subcoil B1
With subcoil B2；
The polarization conducting wire A and polarization conducting wire B is enameled wire；
The subcoil A1 and subcoil B1 package is formed as one first cyclic annular harness 110, the subcoil A2 and
Subcoil B2 package is formed as one another cyclic annular harness 110；
The unidirectional polarized area A and unidirectional polarized area B is overlapped, and forms two-way polarized area；
X to the coil further include two propelling coils 120 to 100, respectively X+ is to propelling coil and X- to promotion
Coil, wherein X+ is located to propelling coil with first cyclic annular harness 110 ipsilateral, and X- is to propelling coil and second ring-type harness
110 positioned at ipsilateral.
Embodiment three
A kind of regulation method for congregating of magnetic particle, process be,
The magnetic particle of dispersion is put into the magnetic tuning area 130 of field system；
It is powered to field system, the energization rule of field system are as follows: be initially powered up from one group of polarization-propelling coil group, one
It is powered off after fixing time, then next polarization adjacent thereto-propelling coil group is powered, so respectively successively to all polarization-
Propelling coil group is powered, and is that a polarization pushes power cycles；
Each polarization-propelling coil group energization rule is to apply electricity to the polarization-propelling coil group polarizing coil group
Pressure is Uj, duration Tj, complete the polarization to magnetic-particle, interval time△The propelling coil 120 of the backward coil group of T is applied
Making alive Ut, duration Tt；Push magnetic-particle along the centerline direction of the propelling coil 120 to perpendicular and
Face by magnetic tuning district center is close；
Repeat the polarization according to energization timing and voltage and push power cycles, formation rotating excitation field, from all directions according to
It is secondary gradually magnetic particle to be pushed to assemble to the center in magnetic tuning area 130.
Specifically, the galvanization of the field system in embodiment one are as follows: line first is pushed to X+ polarizing coil group and X+
Circle is successively powered；Then it is successively powered to Y+ polarizing coil group and Y+ propelling coil；Line is pushed to X- polarizing coil group and X- again
Circle is successively powered；It is finally successively powered to Y- polarizing coil group and Y- propelling coil, completes a power cycles.Against the sequence
It is also feasible for being powered.
Fig. 5 illustrates the process for planar regulating and controlling magnetic particle aggregation, is magnetic in a power cycles shown in figure
The motion state of grain.The distribution of magnetic particle is as shown in a in Fig. 5 under original state, and after bringing into operation, X+ coil group is logical first
Electricity generates magnetic force, and the magnetic particle being pushed closer in the magnetic tuning region 130 of X+ coil group is mobile to middle part, continues for some time
Afterwards, the magnetic-particle in the region is obviously assembled to middle part, and then X+ coil group powers off, at this time magnetic Particles Distribution such as Fig. 5
Shown in middle b, the magnetic particle in the magnetic tuning region 130 of X+ coil group is moved to y-axis；The energization of Y+ coil group generates immediately
Magnetic force, and the magnetic particle being pushed closer in the magnetic tuning region 130 of Y+ coil group is mobile to middle part and assembles, and continues for some time
Afterwards, the magnetic-particle in the region is obviously assembled to x-axis, and then Y+ coil group powers off, at this time in magnetic Particles Distribution such as Fig. 5
Shown in c, the magnetic particle aggregation in Y+ coil group region is at x-axis；X- coil group is powered and generates magnetic force immediately, and promotion is leaned on
Magnetic particle in the magnetic tuning region 130 of nearly X- coil group is mobile to middle part and assembles, after continuing for some time, in the region
Magnetic-particle is significantly built up at middle part, and then X- coil group powers off, and magnetic Particles Distribution is as shown in d in Fig. 5 at this time, close to X-
Magnetic particle in coil group region is to assembling at y-axis；Y- coil group, which is powered, immediately generates magnetic force, and is pushed closer to Y- coil group area
Magnetic particle is mobile to middle part in domain and assembles, and after continuing for some time, the magnetic-particle in the region is significantly built up at middle part, so
The power-off of Y- coil group afterwards, for magnetic Particles Distribution as shown in e in Fig. 5, magnetic particle is obviously poly- to the center in magnetic tuning area at this time
Collection.After carrying out repeatedly repeatedly, magnetic particle can be all gathered at the center in magnetic tuning region 130.
One example of the galvanization of the field system in embodiment two are as follows: the first step pushes away X+ polarizing coil group and X+
Moving winding is successively powered；Second step is successively powered to Y+ polarizing coil group and Y+ propelling coil；Third step Z+ polarizing coil group and Z
+ propelling coil is successively powered；4th step is successively powered to X- polarizing coil group and X- propelling coil；5th step is to Y- polarizing coil
Group and Y- propelling coil are successively powered；6th step is successively powered to Z- polarizing coil group and Z- propelling coil, completes an energization
Period.It will be appreciated by one of ordinary skill in the art that change all directions power-up sequence, and in a power cycles according to
The directive energization of secondary completion institute and feasible.
When three pairs or multipair coil clock synchronization are arranged in plane or in space, according to above-mentioned rule successively to the list of all directions
It is powered to polarization-promotion group, galvanization consecutive variations form multidirectional magnetic field rotationally-varying in plane or in space, from each
A direction is pushed the regulation, it can be achieved that more fine to magnetic particle to magnetic particle.It is contemplated that coil is more to quantity,
It is finer to the motion control of magnetic particle.
Example IV
The difference is that, the energization rule of each polarization-propelling coil group is, first to the pole with embodiment three
It is U that change-propelling coil group polarizing coil group, which applies voltage,jh, duration Tj1, voltage is then reduced to Uj, the duration
For Tj2, and Tj1+Tj2=Tj；
After interval time△T applies voltage U to the propelling coil 120 of the same polarization-propelling coil groupth, continue
Time is Tt1, voltage is then reduced to Ut, duration Tt2, and Tt1+Tt2=Tt。
Reason for doing so is that, since there are inductive impedance effects for coil, when being initially powered, magnetic field strength be one by
The cumulative big process then to tend towards stability.Apply high voltage to coil first, so that the magnetic field strength of coil quickly increases to
Then design value applies lower maintenance voltage again.Compared to the way for applying constant maintenance voltage, this method be can be improved
The responsiveness of field system, so that the movement of magnetic-particle is more controllable.
Embodiment five
According to the method in example IV, effectiveness of the invention is verified.By taking the field system of embodiment one as an example.
By the Fe of 10 milligrams of 20~200nm3O4Magnetic particle is dispersed in 20ml liquid, and then putting it into diameter is 50mm
Vial in, vial is put into magnetic field control region center.Control parameter is set are as follows:
As shown in fig. 6, applying voltage to polarizing coil group is Ujh=540V, duration Tj1=5 μ s, then will be electric
Pressure drop is Uj=150V, duration Tj2=600 μ s, interval time△The promotion line of T=605 μ s, Xiang Suoshu coil group 100
Circle 120 applies voltage Uth=-800V, duration Tt1=40 μ s, are then reduced to U for voltaget=-120V, duration be
Tt2=60 μ s.
In this experiment, power supply energization frequency is 32Hz, and propelling coil electric current reaches 120A, according to the above method to magnetic in plane
Nano particle is assembled.Using the distribution situation of the magnetic particle in vial in videograph pushing course, selected according to the time
Screenshot is taken, as seen from Figure 7, as the time increases, planar magnetic nano particle is uniformly distributed and is constantly converged to central area, when
When instrument work 180s, magnetic nano particle is significantly built up in central area.
Embodiment six
Remoter apart from some propelling coil when magnetic-particle moves in a liquid, the motive force being subject to is smaller, in addition, also
By liquid resistance and with the frictional force of bottom of bottle.It therefore, can by setting electric current size to obtain magnetic field strength appropriate
So that magnetic-particle is assembled slowly, controllably, step by step.Further, when can also apply voltage value by changing and be powered
Between, move the magnetic cluster of grains of aggregation along particular course, as shown in figure 8, being magnetic cluster of grains in circle in figure.
This experiment, to obtain magnetic field appropriate, realizes magnetic nano particle in magnetic repulsion by rationally control power-supply system
It constantly travels forward under effect, by the promotion of four in-planes, constantly magnetic nano particle is gathered in magnetic tuning region
The heart.By changing electricity parameters, the magnetic nano particle group after can also making aggregation moves or is pushed to target position along particular course
It sets.The method and apparatus of such aggregation magnetic particle can be applied to field of biomedicine laboratory research, such as deep tumor cell
Targeting removal, the targeted therapy for the load medicine magnetic particle under more complicated, closer bio-tissue environment provide basis.
Finally, it should be noted that foregoing description is only the preferred embodiment of the present invention, the ordinary skill people of this field
Member under the inspiration of the present invention, without prejudice to the purpose of the present invention and the claims, can make multiple similar tables
Show, such transformation is fallen within the scope of protection of the present invention.
Claims (10)
1. a kind of regulation focusing device of magnetic nano particle, it is characterised in that: including field system；
The field system includes at least two pairs of coils to (100), and a pair of coil includes two groups of polarizing coils to (100)
Group, polarizing coil group described in one group include two subcoils；
Same group of two subcoils are parallel, face setting, and conducting wire is around to identical, same group of two subcoils
Between form unidirectional polarized area；
It is parallel to each other between subcoil with two a pair of polarizing coil groups, with two a pair of polarizing coil groups
Conducting wire around on the contrary, the unidirectional polarized area mutual with two a pair of polarizing coil groups is intersected, to form two-way polarization
Area；
A pair of coil further includes two propelling coils (120) to (100), the center line of the propelling coil (120) and same
The center line of the centerline parallel of the subcoil in one pair, two propelling coils (120) is located along the same line, and two
A propelling coil (120) is located at the two sides of the corresponding two-way polarized area, two propelling coils (120) it is interior
End is respectively facing the corresponding two-way polarized area；
The different pairs of coil is to mutual angle between the subcoil of (100)；
The different pairs of coil intersects the two-way polarized area mutual of (100), to form magnetic tuning area (130).
2. a kind of regulation focusing device of magnetic nano particle according to claim 1, it is characterised in that: with a pair of two
The center line of the subcoil of the polarizing coil group is overlapped.
3. a kind of regulation focusing device of magnetic nano particle according to claim 2, it is characterised in that: two of same group
The subcoil is formed by same root polarization conducting wire coiling in the same direction, and the interlude of the polarization conducting wire is perpendicular to described in corresponding two
Subcoil, the both ends of the polarization conducting wire interlude are connected separately with the identical subcoil of winding turns；
Same group of two subcoils are mutually wrapped up with identical internal another group of two subcoils；
With the unidirectional polarization area overlapping of two a pair of polarizing coil groups, to make the two-way polarized area and unidirectional polarization
Area is overlapped.
4. a kind of regulation focusing device of magnetic nano particle according to claim 3, it is characterised in that: the propelling coil
(120) center line is overlapped with the center line of the same internal subcoil, forms regulation center line；
The center line of all propelling coils (120) intersects at the center of the magnetic tuning area (130).
5. a kind of regulation focusing device of magnetic nano particle according to claim 1, it is characterised in that: the subcoil is
Square coil, its side length is L；
The distance between same group two described subcoils are D, D=L/2.
6. a kind of according to claim 1, regulation focusing device of magnetic nano particle described in 2,3,4 or 5, it is characterised in that: institute
Stating propelling coil (120) is solenoid, radius r, propelling coil (120) inner face to the magnetic tuning area (130)
The distance at center is d,
7. a kind of regulation focusing device of magnetic nano particle according to claim 4, it is characterised in that: all coils
Center circumferential direction to (100) in the same plane around the magnetic tuning area (130) is uniformly distributed.
8. a kind of regulation focusing device of magnetic nano particle according to claim 4 or 7, it is characterised in that: the coil
There are two pairs to (100), two pairs of coils are mutually perpendicular to the regulation center line of (100).
9. a kind of regulation focusing device of magnetic nano particle according to claim 4, it is characterised in that: all coils
(100) are distributed in three-dimensional space with the center diverging of the magnetic tuning area (130).
10. a kind of regulation focusing device of magnetic nano particle according to claim 4 or 9, it is characterised in that: the coil
There are three pairs to (100), three pairs of coils are mutually perpendicular to the regulation center line of (100), tune of three pairs of coils to (100)
Control center line is orthogonal to the center of the magnetic tuning area (130).
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Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009056232A (en) * | 2007-09-03 | 2009-03-19 | Toshiba Corp | Magnetic particle imaging apparatus and coil arrangement method |
| CN103945760A (en) * | 2011-11-16 | 2014-07-23 | 皇家飞利浦有限公司 | Apparatus and method for influencing and/or detecting magnetic particles having a large field of view |
| WO2015046672A1 (en) * | 2013-09-24 | 2015-04-02 | 경상대학교산학협력단 | Three-dimensional electromagnetic drive device for delivery of magnetic nanoparticles |
| CN105079971A (en) * | 2011-08-26 | 2015-11-25 | 安都磁学有限公司 | Apparatus for the generation of an energy field for the treatment of cancer in body cavities and parts that are cavity-like |
| US20170067972A1 (en) * | 2014-05-07 | 2017-03-09 | The Trustees Of Dartmouth College | Method And Apparatus For Nonlinear Susceptibility Magnitude Imaging Of Magnetic Nanoparticles |
| CN107320723A (en) * | 2017-08-08 | 2017-11-07 | 重庆科技学院 | Magnetic nano-particle method for congregating based on three-dimensional magnetic field |
| CN107946018A (en) * | 2017-12-29 | 2018-04-20 | 中国科学院电工研究所 | A kind of focusing magnetic field regulation device |
| CN108198677A (en) * | 2017-12-29 | 2018-06-22 | 中国科学院电工研究所 | A kind of focusing magnetic field regulator control system for nano particle |
| CN108744257A (en) * | 2018-03-30 | 2018-11-06 | 深圳海磁康科技有限责任公司 | Magnetic and medicated targeting method for congregating and magnet structure |
| CN210933423U (en) * | 2019-05-31 | 2020-07-07 | 重庆科技学院 | Regulation and control focusing device for magnetic nanoparticles |
-
2019
- 2019-05-31 CN CN201910470804.0A patent/CN110064128B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009056232A (en) * | 2007-09-03 | 2009-03-19 | Toshiba Corp | Magnetic particle imaging apparatus and coil arrangement method |
| CN105079971A (en) * | 2011-08-26 | 2015-11-25 | 安都磁学有限公司 | Apparatus for the generation of an energy field for the treatment of cancer in body cavities and parts that are cavity-like |
| CN103945760A (en) * | 2011-11-16 | 2014-07-23 | 皇家飞利浦有限公司 | Apparatus and method for influencing and/or detecting magnetic particles having a large field of view |
| WO2015046672A1 (en) * | 2013-09-24 | 2015-04-02 | 경상대학교산학협력단 | Three-dimensional electromagnetic drive device for delivery of magnetic nanoparticles |
| US20170067972A1 (en) * | 2014-05-07 | 2017-03-09 | The Trustees Of Dartmouth College | Method And Apparatus For Nonlinear Susceptibility Magnitude Imaging Of Magnetic Nanoparticles |
| CN107320723A (en) * | 2017-08-08 | 2017-11-07 | 重庆科技学院 | Magnetic nano-particle method for congregating based on three-dimensional magnetic field |
| CN107946018A (en) * | 2017-12-29 | 2018-04-20 | 中国科学院电工研究所 | A kind of focusing magnetic field regulation device |
| CN108198677A (en) * | 2017-12-29 | 2018-06-22 | 中国科学院电工研究所 | A kind of focusing magnetic field regulator control system for nano particle |
| CN108744257A (en) * | 2018-03-30 | 2018-11-06 | 深圳海磁康科技有限责任公司 | Magnetic and medicated targeting method for congregating and magnet structure |
| CN210933423U (en) * | 2019-05-31 | 2020-07-07 | 重庆科技学院 | Regulation and control focusing device for magnetic nanoparticles |
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