KR101916413B1 - Apparatus for concentrating nanoparticles and method for controlling the same - Google Patents

Apparatus for concentrating nanoparticles and method for controlling the same Download PDF

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KR101916413B1
KR101916413B1 KR1020160145654A KR20160145654A KR101916413B1 KR 101916413 B1 KR101916413 B1 KR 101916413B1 KR 1020160145654 A KR1020160145654 A KR 1020160145654A KR 20160145654 A KR20160145654 A KR 20160145654A KR 101916413 B1 KR101916413 B1 KR 101916413B1
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magnetic field
magnetic
type
frequency
nanoparticles
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KR1020160145654A
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KR20180049580A (en
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이용흠
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연세대학교 원주산학협력단
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Priority to KR1020160145654A priority Critical patent/KR101916413B1/en
Priority to PCT/KR2017/011647 priority patent/WO2018084474A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves
    • A61N5/022—Apparatus adapted for a specific treatment
    • A61N5/025—Warming the body, e.g. hyperthermia treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
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  • Medical Informatics (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Abstract

Wherein the nanoparticle concentrating apparatus comprises at least one magnetic field generating unit for generating a magnetic field, at least one magnetic substance magnetized by the magnetic field, and a control unit for generating a control signal for controlling the operation of the magnetic field generating unit Wherein the magnetic body can focus a nanoparticle including a drug introduced into the living body as it is magnetized by the magnetic field, into a lesion in an area of the magnetic field.

Description

TECHNICAL FIELD [0001] The present invention relates to a nanoparticle concentration device and a method of driving the same. BACKGROUND ART [0002]

The present invention relates to a nanoparticle concentrating apparatus and a driving method thereof.

In the case of cancer treatment, the amount of anticancer drug actually administered to the user's body should be actually higher than the amount of anticancer drug needed in the place where the cancer is caused by blood circulation in the human body. In this case, administration of more than necessary anticancer drugs to the human body will adversely affect other tissues and organs, resulting in numerous side effects. Examples of side effects include nausea, vomiting, hair loss, infection, fatigue, anemia, bleeding, diarrhea, Discoloration, and heat sensation.

In order to overcome these problems, research and development of Drug Delivery System (DDS), which aims to increase the targeting efficiency of anticancer drugs, is actively carried out in order to prevent the administration of anticancer drugs more than necessary in related fields.

A drug delivery system is a system for improving administration techniques and formulations and controlling the in vivo movement of a drug to increase the stability, efficacy or reliability of the drug to the living body, It is also required to administer the composition so that the desired concentration can be maintained.

One of the various methods of implementing a drug delivery system is to use a nanoparticle, which involves introducing a drug into the nanoparticles that are attracted to the magnet and inducing the substance to the desired site using a single magnet to be.

However, there is a disadvantage in that the efficiency of drug targeting is deteriorated because the ratio of inducing the substance to a desired position in the human body is extremely low. In addition, in the conventional method, it is possible to induce the substance only in the affected part of the skin surface, and there is a problem that the substance can not be induced by the organ existing in the deep part of the human body. Therefore, it is effective for the treatment of diseases such as skin cancer existing on the surface of the skin, but it is disadvantageous in that it is ineffective for the treatment of diseases occurring in the deep part of human body.

The background technology of the present application is disclosed in Korean Patent Registration No. 10-1406632 (filed on Apr. 2014.06.03).

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above problems of the prior art, and it is an object of the present invention to provide a nanoparticle concentrating device and a driving method thereof capable of remarkably increasing the rate of inducing a drug by concentrating nanoparticles in a lesion portion so as to maximize a drug treatment effect .

It is an object of the present invention to provide a nanoparticle concentration device capable of suppressing the proliferation of cancer cells and necrosing cancer cells by conducting heat to the nanoparticles concentrated in the affected part, and a driving method thereof do.

It is to be understood, however, that the technical scope of the embodiments of the present invention is not limited to the above-described technical problems, and other technical problems may exist.

According to an aspect of the present invention, there is provided a nano particle concentration apparatus comprising at least one magnetic field generating unit generating a magnetic field, at least one magnetic body magnetized by the magnetic field, Wherein the magnetic body is capable of focusing a nanoparticle including a drug introduced into the living body as it is magnetized by the magnetic field, into a lesion in the region of the magnetic field have.

Also, the control unit may control at least one of the intensity, frequency, time, and pattern of the magnetic field as the type of the magnetic field generated from the magnetic field generating unit.

In addition, the controller may control the type of the magnetic field to concentrate the nanoparticles or conduct heat to the nanoparticles.

The control unit controls the frequency of the magnetic field to 100 kHz to 300 kHz and the magnetic body is magnetized or demagnetized by a magnetic field having a frequency of 100 kHz to 300 kHz to generate heat, It can conduct heat to nanoparticles.

Further, the nanoparticle concentration apparatus according to an embodiment of the present invention may further include a sensor unit for measuring the number of nanoparticles concentrated on the lesion portion, wherein the control unit determines whether the number of nanoparticles concentrated on the lesion portion exceeds a preset reference The type of the magnetic field can be changed from the first type to the second type.

The control unit controls the type of the magnetic field to a frequency of 30 Hz or less as a first type in order to concentrate the nanoparticles, and when it is determined that the number of nanoparticles concentrated in the affected part exceeds a preset reference The type of the magnetic field is controlled as a second type at a frequency between 100 kHz and 300 kHz and the magnetic body is magnetized or demagnetized by a magnetic field having the frequency of the second type to generate heat to heat the nanoparticles You can evangelize.

The control unit may control the type of the magnetic field to a frequency of 30 Hz or less as a first type for a first predetermined time to concentrate the nanoparticles, And the magnetic body is magnetized or demagnetized by a magnetic field having a frequency of the second type to generate heat to heat the nanoparticles to a temperature of about < RTI ID = 0.0 >Lt; / RTI >

Further, the magnetic body may be located in the magnetic field generating portion, or may be located in the affected portion by at least one of attachment, insertion, and implantation.

The magnetic body located within the magnetic field generating portion may include a magnetic body needle and a spherical magnetic body coupled to an end of the magnetic body needle.

The magnetic field generating unit may include a magnetic field core formed with a through hole and a coil wound around the magnetic core, and the magnetic body may be positioned through the through hole.

Further, the magnetic substance may be a spherical magnetic substance.

In addition, the controller may change the frequency of the magnetic field at predetermined time intervals.

In addition, when the plurality of magnetic field generating units are included, the control unit may control different types of magnetic fields generated from the plurality of magnetic field generating units.

The magnetic field generator may generate a pulsed electromagnetic field (PEMF).

The magnetic field generator includes a first magnetic field generator, a second magnetic field generator, and a third magnetic field generator, and the first magnetic field generator, the second magnetic field generator, and the third magnetic field generator generate magnetic fields Can be arranged at three angles such that the regions of the first and second electrodes cross each other.

Meanwhile, a driving method of a nano particle concentration apparatus according to an embodiment of the present invention includes generating a magnetic field control signal, generating a magnetic field based on the magnetic field control signal, and magnetizing the magnetic body by the magnetic field can do.

The step of generating the magnetic field control signal may include the steps of: (a) generating a control signal to control the type of the magnetic field to a frequency of 30 Hz or less as a first type; and (b) Generating a control signal for controlling the type of the nano-particle concentrator at a frequency between 100 kHz and 300 kHz as a second type, wherein the driving method of the nanoparticle concentrating device comprises: And generating heat.

The above-described task solution is merely exemplary and should not be construed as limiting the present disclosure. In addition to the exemplary embodiments described above, there may be additional embodiments in the drawings and the detailed description of the invention.

According to the above-mentioned problem solving means of the present invention, by concentrating nanoparticles containing a drug introduced into a living body into a living body as the magnetic body is magnetized by a magnetic field, the rate of drug induction (targeting ratio) is remarkably increased And the effect of the drug treatment can be maximized.

According to the above-mentioned problem solving method of the present invention, the concentration of nanoparticles in the affected part is controlled differently and the type of the magnetic field is controlled differently, thereby transferring heat to the concentrated nanoparticles, thereby inhibiting the proliferation of cancer cells and necrosing cancer cells.

Further, the effects obtainable here are not limited to the effects mentioned above, and other effects not mentioned can be clearly understood by those skilled in the art from the following description will be.

1 is a schematic block diagram of a nanoparticle concentrating device according to one embodiment of the present invention.
FIG. 2A is a diagram schematically showing the configuration of a magnetic field generating unit according to the first embodiment in a nano particle concentration apparatus according to an embodiment of the present invention. FIG.
FIG. 2B is a view showing a configuration of a magnetic body in a nanoparticle concentrating apparatus according to an embodiment of the present invention.
FIG. 3 is a view schematically showing a configuration of a magnetic field generating unit according to a second embodiment in a nano particle concentration apparatus according to an embodiment of the present invention.
FIG. 4 is a diagram illustrating an example of a magnetic field stimulation mode scheme in a nanoparticle concentrating apparatus according to an embodiment of the present invention.
FIG. 5 is a diagram illustrating a concentrated mode and a heating mode in a nano-particle concentration apparatus according to an embodiment of the present invention.
FIG. 6 is a view showing a configuration of a plurality of magnetic field generating units in a nano particle concentration apparatus according to an embodiment of the present invention.
FIG. 7 is a view showing another configuration of a plurality of magnetic field generating units in a nano particle concentration apparatus according to an embodiment of the present invention.
FIG. 8 is a schematic operation flowchart of a method of driving a nano-particle concentration device according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. It should be understood, however, that the present invention may be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In the drawings, the same reference numbers are used throughout the specification to refer to the same or like parts.

Throughout this specification, when an element is referred to as being "connected" to another element, it is intended to be understood that it is not only "directly connected" but also "electrically connected" or "indirectly connected" "Is included.

It will be appreciated that throughout the specification it will be understood that when a member is located on another member "top", "top", "under", "bottom" But also the case where there is another member between the two members as well as the case where they are in contact with each other.

Throughout this specification, when an element is referred to as "including " an element, it is understood that the element may include other elements as well, without departing from the other elements unless specifically stated otherwise.

The present invention relates to a nanoparticle concentrating device capable of suppressing the proliferation of cancer cells and necrosing cancer cells by concentrating nanoparticles containing a drug introduced into the living body into the lesion and controlling the type of magnetic field to conduct heat to the concentrated nanoparticles And a driving method thereof.

1 is a schematic block diagram of a nanoparticle concentrating device according to one embodiment of the present invention.

Referring to FIG. 1, the nanoparticle concentrating apparatus 100 according to an embodiment of the present invention may include a magnetic field generating unit 110, a magnetic body 120, and a controller 130.

The magnetic field generating unit 110 may generate a magnetic field based on a control signal from the controller 130 and the nanoparticle concentrating apparatus 100 may include at least one magnetic field generating unit 110. At this time, the magnetic field generated from the magnetic field generator 110 may be a Pulsed Electro-Magnetic Field (PEMF).

The magnetic body 120 may be magnetized by a magnetic field generated from the magnetic field generating unit 110 and the nanoparticle concentrating apparatus 100 may include at least one magnetic body 120.

The magnetic body 120 is magnetized by the magnetic field generated from the magnetic field generating unit 110 so that the nanoparticles containing the drug introduced into the user's body (or the living body 1) . A more detailed description follows.

Here, the magnetic field generating unit 110 and the magnetic body 120 may be formed in the shape as shown in FIGS. 2A and 2B according to the first embodiment, or may be formed in the shape as shown in FIG. 3 according to the second embodiment. have.

First, the shape of the magnetic field generating portion 110 'and the magnetic body 120' according to the first embodiment can be more easily understood with reference to FIGS. 2A and 2B.

2A is a schematic view illustrating a configuration of a magnetic field generator 110 'according to the first embodiment of the nano particle concentration apparatus 100 according to an embodiment of the present invention, and FIG. 1 is a diagram showing a configuration of a magnetic body 120 'according to the first embodiment in the nano particle concentrating apparatus 100. FIG.

2A and 2B, the magnetic field generator 110 'according to the first embodiment of the nano particle concentrating apparatus 100 according to the embodiment of the present invention includes a magnetic field core 110' having a through hole 110a formed at its center portion And a coil 110c wound around the magnetic field core 110b. The magnetic field core 110b can be, for example, cylindrical in shape, but is not limited thereto. The coil 110c may be wound around the magnetic field core 110b.

In the nanoparticle concentrating apparatus 100 according to the embodiment of the present invention, the magnetic body 120 'according to the first embodiment includes a magnetic body 120a and a spherical magnetic body 120b coupled to one end of the magnetic body 120a. . ≪ / RTI > Here, the spherical magnetic body 120b may be formed to have a diameter larger than the diameter of the magnetic body needles 120a so that the nanoparticles can be concentrated as much as possible in the magnetic field region. Here, the term 'diameter' Rather than being narrowly interpreted, it can be broadly interpreted to mean various widths. In addition, although the magnetic substance 120 'according to the first embodiment of the present invention is illustrated as having a spherical shape, the shape of the spherical magnetic substance 120b is not limited thereto, and its shape can be variously modified.

The magnetic body 120 'according to the first embodiment may be located in the through hole 110a of the magnetic field generating portion 110' and may be positioned at a position such that a part of the magnetic body needle 120a passes through the through hole 110a. can do. The magnetic needle 120a may serve as a needle so that a portion of the magnetic needle 120a and the spherical magnetic body 120b formed at the end of the magnetic body 120 ' As shown in Fig.

2A shows a case where a part of the magnetic body 120 'is inserted into the user's body 1. For example, when a magnetic field is generated through the magnetic field generating part 110' in this state, A magnetic field region s may be formed in a peripheral region around the spherical magnetic body 120b formed at the end of the magnetic body 120 '. The magnetic body 120'is magnetized by the magnetic field generated from the magnetic field generating part 110'to attract the nanoparticles 2 containing the drug introduced into the living body 1 to the lesion part in the magnetic field area s, Can be concentrated in the cancer tissue.

The shapes of the magnetic field generating portion 110 '' and the magnetic substance 120 '' according to the second embodiment can be more easily understood with reference to FIG.

FIG. 3 is a view schematically showing a configuration of a magnetic field generating unit according to a second embodiment in a nano particle concentration apparatus according to an embodiment of the present invention.

Referring to FIG. 3, the magnetic field generating unit 110 '' according to the second embodiment of the nano particle concentrating apparatus 100 according to the embodiment of the present invention includes a magnetic field core 110b 'and a magnetic field core 110b' And may include a wound coil 110c '. Unlike the magnetic field core 110b of the magnetic field generating portion 110 'according to the first embodiment, the magnetic field core 110b' of the magnetic field generating portion 110 '' according to the second embodiment has a through hole at its center portion Can be absent. The magnetic field core 110b 'may be, for example, cylindrical in shape and is not limited thereto. The coil 110c 'may be wound around the magnetic field core 110b'.

Further, in the nanoparticle concentrating apparatus 100 according to the embodiment of the present invention, the magnetic substance 120 '' according to the second embodiment may be a spherical magnetic substance. The magnetic body 120 " according to the second embodiment may be located at the affected part of the user's body 1 by at least one of attachment, insertion and implantation. That is, the magnetic body 120 '' may be attached to the surface of the user's body 1 or inserted or implanted in the user's body 1. Although the shape of the magnetic body 120 " is illustrated as being spherical, the shape of the magnetic body 120 " is not limited thereto and may be variously modified.

3 shows a case where the magnetic body 120 '' is attached to the surface of the user's body 1, for example. In this state, a magnetic field is generated through the magnetic field generating portion 110 '' , A magnetic field region (s) dl may be formed in a peripheral region around the magnetic substance 120 ''. The magnetic substance 120 "is magnetized by the magnetic field generated from the magnetic field generating section 110", and the nanoparticles 2 containing the drug that has flowed into the living body 1, , Especially in cancer tissues.

Meanwhile, the control unit 130 may generate a control signal for controlling the operation of the magnetic field generating unit 110. The control unit 130 may generate a control signal based on the user input.

When a magnetic field is generated from the magnetic field generation unit 110 based on the control signal of the control unit 130, the magnetic body 120 is magnetized by a magnetic field, so that the nano- It is possible to concentrate the particles 2 to the lesion portion in the magnetic field (s) region.

The controller 130 can control the type of the magnetic field generated from the magnetic field generator 110 and can control at least one of the intensity, frequency, time, and pattern of the magnetic field as the type of the magnetic field.

The controller 130 may control the magnetic field generator 110 so that the magnetic field generator 110 generates a magnetic field stimulus corresponding to the magnetic field stimulation mode information input from the user. The magnetic field stimulation mode can be more easily understood from FIG.

FIG. 4 is a diagram illustrating an example of a magnetic field stimulation mode scheme in a nanoparticle concentrating apparatus according to an embodiment of the present invention.

Referring to FIG. 4, the nanoparticle concentrating apparatus 100 according to an embodiment of the present invention may receive magnetic field stimulation mode information from a user. For example, an N pulse stimulation mode, an S pulse stimulation mode, An N-pulse continuous stimulation mode, and an S-pulse continuous stimulation mode. Accordingly, the controller 130 receives a magnetic field stimulus corresponding to any one of N pulse stimulus, S pulse stimulus, alternate stimulus of N pulse and S pulse, N pulse continuous stimulus and S pulse continuous stimulus from the magnetic field generator 110 The magnetic field generator 110 can be controlled to generate the magnetic field.

In addition, the control unit 130 can control at least one of the intensity, frequency, time, and pattern of the magnetic field as the type of the magnetic field, thereby concentrating the nanoparticles in the affected area or conducting heat to the concentrated nanoparticles. This can be more easily understood with reference to FIG.

FIG. 5 is a diagram illustrating a concentrated mode and a heating mode in a nano-particle concentration apparatus according to an embodiment of the present invention.

Referring to FIG. 5, the controller 130 controls the magnetic field of the magnetic field generator 110 'to control the mode of the magnetic field generator 110' It can be controlled as a heat generation mode in which heat is conducted to nanoparticles.

Specifically, Fig. 5 (a) shows the concentrated mode and Fig. 5 (b) shows the heat generation mode.

As shown in FIG. 5A, the controller 130 can control the magnetic field of the magnetic field generator 110 'at a frequency of 30 Hz or less in order to concentrate the nanoparticles.

5B, the control unit 130 may control the type of the magnetic field of the magnetic field generating unit 110 'at a high frequency in order to conduct heat to the concentrated nanoparticles. For example, (130) can be controlled as any one of 100 kHz to 300 kHz as a high frequency. At this time, as a magnetic field having a frequency of 100 kHz to 300 kHz is generated from the magnetic field generator 110 ', the magnetic body 120' can be quickly magnetized or demagnetized to generate heat, The heat generated from the magnetic body 120 '' 'can be transferred to the nanoparticles 2 located in the magnetic field region s. Accordingly, in the heat generation mode, the heat generated from the exothermic magnetic substance 120 '' 'is transferred to the nanoparticles 2 to necrotize cancer cells in cancer tissues or inhibit the proliferation of cancer cells.

Meanwhile, the nanoparticle concentrating apparatus 100 according to one embodiment of the present invention may include a sensor unit (not shown) for measuring the number of nanoparticles concentrated on the affected part.

The sensor unit (not shown) can count the number of nanoparticles 2 concentrated in the magnetic field area s of the affected part. For example, the nanoparticles may be a fluorescent substance, and the sensor unit may include a fluorescence sensor, an image sensor, an infrared sensor, and the like capable of detecting nanoparticles, but the present invention is not limited thereto.

The control unit 130 may control the type of the magnetic field of the magnetic field generating unit 110 in consideration of the measured value of the number of nanoparticles through the sensor unit.

Specifically, the controller 130 may change the type of the magnetic field of the magnetic field generator 110 from the first type to the second type according to whether or not the number of nanoparticles concentrated in the affected part exceeds a preset reference.

For example, the first type may be a type of the intensive mode in which the magnetic field of the magnetic field generator 110 has a frequency of 30 Hz or less, and the second type may be a frequency of a magnetic field of the magnetic field generator 110 of 100 kHz to 300 kHz But it is not limited thereto.

The control unit 130 controls the type of the magnetic field of the magnetic field generating unit 110 to the first type which is a frequency of 30 Hz or less in order to concentrate the nanoparticles 2 in the affected part or the magnetic field area s, the control unit 130 may change the type of the magnetic field to the second type, which is a frequency between 100 kHz and 300 kHz in the first type, when it is determined that the number of nanoparticles concentrated in the first type exceeds the preset reference. At this time, the magnetic body 120 'generated by the magnetic field having the frequency of the second type may change its state to the exothermic body 120' '' that generates heat due to magnetization or demagnetization, Quot; can conduct heat to the nanoparticles concentrated in the affected area or in the magnetic field area " s ".

In addition, the controller 130 controls the type of the magnetic field of the magnetic field generator 110 to the first type for a first predetermined time to concentrate the nanoparticles, and for a second predetermined time after the first time has elapsed The type of the magnetic field of the magnetic field generating section 110 can be controlled to the second type. For example, the control unit 130 can control the type of the magnetic field of the magnetic field generating unit 110 to the first type for 10 minutes, and to the second type for 3 minutes after 10 minutes have elapsed.

Also, the control unit 130 may change the frequency of the magnetic field generated from the magnetic field generating unit 110 at predetermined time intervals. At this time, the controller 130 may control the time interval at which the frequency is changed according to the type of the magnetic field. For example, when the type of the magnetic field generated from the magnetic field generator 110 is controlled in the heat generation mode, the controller 130 may control the frequency to change at intervals of 10 seconds within a frequency range of 100 kHz to 300 kHz . Specifically, the controller 130 controls the frequency of the magnetic field to 100 kHz for 10 seconds, controls the frequency to 230 kHz for 10 seconds, controls the frequency to 150 kHz for 10 seconds, and controls the frequency to 280 kHz for 10 seconds The frequency can be controlled to change every 10 seconds. At this time, the frequency change may be changed regularly or irregularly. For example, when the type of the magnetic field generated from the magnetic field generator 110 is controlled in the concentrated mode, the controller 130 controls the frequency to be changed every 30 seconds within a frequency of 30 Hz or less. At this time, the frequency change can be changed regularly or irregularly as mentioned above.

Meanwhile, the nanoparticle concentrating apparatus 100 according to an embodiment of the present invention may include a plurality of magnetic field generating units 110, and the positions and the number of the plurality of magnetic field generating units 110 may be variously implemented. For example, a configuration example of the plurality of magnetic field generators 110 can be more easily understood with reference to FIGS. 6 and 7. FIG.

FIG. 6 is a view showing a configuration of a plurality of magnetic field generating units in a nano particle concentration apparatus according to an embodiment of the present invention.

Referring to FIG. 6, the nano particle concentration apparatus 100 according to an embodiment of the present invention includes a first magnetic field generating unit 110'A, a second magnetic field generating unit 110'B And a third magnetic field generating unit 110'C.

In this case, the first magnetic field generating unit 110'A, the second magnetic field generating unit 110'B, and the third magnetic field generating unit 110'C may be triangularly arranged such that areas of the magnetic fields generated by the first magnetic field generating unit 110'A, As shown in FIG. Specifically, the first magnetic field region s1 formed by the first magnetic substance 120'A located in the first magnetic field generation portion 110'A, the second magnetic field region s1 generated by the second magnetic field generation portion 110'B located within the second magnetic field generation portion 110'B, The second magnetic field region s2 formed by the third magnetic field generating portion 110'C and the third magnetic field region s3 formed by the third magnetic substance 120'C located within the third magnetic field generating portion 110'C The first magnetic field generating portion 110'A to the third magnetic field generating portion 110'C may be arranged at three angles. Through such an arrangement, the nanoparticle concentrating apparatus 100 according to an embodiment of the present invention concentrates nanoparticles in the treatment site (or lesion) of a desired user as much as possible, and then, by conducting heat to the nanoparticles, .

When the plurality of magnetic field generators 110 are included, the controller 130 may control the types of the magnetic fields generated by the plurality of magnetic field generators 110, respectively. For example, in the case of FIG. 6, the controller 130 controls the type of the magnetic field to be the first type by the first magnetic field generator 110'A, and the second magnetic field generator 110'B controls the second Type, and the third magnetic field generating unit 110'C may control the third type different from the first type and the second type. Alternatively, the first magnetic field generating unit 110'A and the second magnetic field generating unit 110'B may be controlled to be of the first type and the third magnetic field generating unit 110'C may be controlled to the second type .

When the plurality of magnetic field generators 110 are included, the controller 130 not only determines the type of the magnetic field but also the frequency change time of the magnetic field generated from each of the plurality of magnetic field generators 11, the magnetic field stimulation time, Can be controlled differently.

6, a plurality of magnetic field generating units 110'A, 110'B, and 110'C and a plurality of magnetic bodies 120'A, 120'B, and 120'C located in the respective magnetic field generating units 110'A, 110'B, The shape of the magnetic field generating portion 110 '' and the magnetic body 120 '' according to the second embodiment is not limited to the shape of the magnetic field generating portion 110 'and the magnetic body 120' .

FIG. 7 is a view showing another configuration of a plurality of magnetic field generating units in a nano particle concentration apparatus according to an embodiment of the present invention.

Referring to FIG. 7, the nano particle concentration apparatus 100 according to one embodiment of the present invention may include four magnetic field generators 110 '' as a plurality of magnetic field generators 110, As shown in FIG.

In Fig. 7, for example, three magnetic bodies can be attached, inserted or implanted as a plurality of spherical magnetic bodies 120 " to the user's body, and nanoparticles are concentrated around the three spherical magnetic bodies 120 " The four magnetic field generators 110 '' can be positioned in the up, down, right, left or front / rear left / right directions. As described above, the controller 1300 can control the type of the magnetic field, the stimulation time, the stimulation frequency change time, and the like with respect to each of the four magnetic field generators 110 ''.

Hereinafter, the operation flow of the present invention will be briefly described based on the details described above.

FIG. 8 is a schematic operation flowchart of a method of driving a nano-particle concentration device according to an embodiment of the present invention.

The driving method of the nanoparticle concentration apparatus shown in FIG. 8 can be performed by the nanoparticle concentration apparatus 100 described above. Therefore, the contents described for the nanoparticle concentrating apparatus 100 can be similarly applied to FIG. 8 even if omitted below.

Referring to FIG. 8, in step S810, a magnetic field control signal may be generated through the controller 130. FIG.

At this time, in step S810, the controller 130 may generate a control signal for controlling the type of the magnetic field generated from the magnetic field generator 110 to a frequency of 30 Hz or less as a first type. The control unit 130 may generate a control signal for controlling the frequency of 30 Hz or less and then generate a control signal for controlling the type of the magnetic field to a frequency between 100 kHz and 300 kHz as the second type.

Next, in step S820, a magnetic field can be generated through the magnetic field generating section 110 based on the magnetic field control signal generated in step S810.

At this time, in step S820, a magnetic field corresponding to a frequency of 30 Hz or less can be generated through the magnetic field generator 110 based on the first type control signal. In addition, in step S820, a magnetic field corresponding to a frequency between 100 kHz and 300 kHz may be generated through the magnetic field generator 110 based on the second type of control signal.

Next, in step S830, the magnetic body 120 can be magnetized by the magnetic field generated in step S820.

At this time, in step S830, the magnetic substance 120 is magnetized by the magnetic field corresponding to the first type, so that the nanoparticles containing the drug can be concentrated in the magnetic field region s formed by the magnetic substance 120. [

In addition, in step S830, the magnetic substance 120 may be magnetized or demagnetized by the magnetic field corresponding to the second type to generate heat from the magnetic substance 120. [ Accordingly, the heat generated from the magnetic substance 120 can be conducted to nanoparticles concentrated in the magnetic field region (s), thereby more effectively inhibiting the proliferation of cancer cells and necrosing cancer cells.

In addition, although not shown in the drawing, the driving method of the nano particle concentrating apparatus according to an embodiment of the present invention may further include a step of changing the type of the magnetic field generated from the magnetic field generating unit 110.

At this time, the type of the magnetic field can be changed based on the number of nanoparticles concentrated on the affected part. The type of the magnetic field can also be controlled to operate with a preset type of magnetic field for a predetermined time. In addition, the type of the magnetic field can be controlled so that the frequency of the magnetic field changes at predetermined time intervals. A more specific example of this has been described in detail above, and the following description will be omitted.

In the above description, steps S810 through S830 may be further divided into further steps, or combined in fewer steps, according to embodiments of the present disclosure. Also, some of the steps may be omitted as necessary, and the order between the steps may be changed.

The method of driving the nanoparticle concentrating device according to one embodiment of the present invention may be implemented in the form of a program command that can be executed through various computer means and recorded in a computer readable medium. The computer-readable medium may include program instructions, data files, data structures, and the like, alone or in combination. The program instructions recorded on the medium may be those specially designed and constructed for the present invention or may be available to those skilled in the art of computer software. Examples of computer-readable media include magnetic media such as hard disks, floppy disks and magnetic tape; optical media such as CD-ROMs and DVDs; magnetic media such as floppy disks; Magneto-optical media, and hardware devices specifically configured to store and execute program instructions such as ROM, RAM, flash memory, and the like. Examples of program instructions include machine language code such as those produced by a compiler, as well as high-level language code that can be executed by a computer using an interpreter or the like. The hardware devices described above may be configured to operate as one or more software modules to perform the operations of the present invention, and vice versa.

In addition, the above-described method of driving the nanoparticle concentrating device can also be implemented in the form of a computer program or an application executed by a computer stored in a recording medium.

It will be understood by those of ordinary skill in the art that the foregoing description of the embodiments is for illustrative purposes and that those skilled in the art can easily modify the invention without departing from the spirit or essential characteristics thereof. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims rather than the detailed description, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be interpreted as being included in the scope of the present invention.

100: Nano particle concentration device
110, 110 ', 110'':
120, 120 ', 120'': magnetic substance
130:

Claims (18)

At least one magnetic field generating section for generating a magnetic field;
At least one magnetic body magnetized by the magnetic field; And
A control unit for generating a control signal for controlling the operation of the magnetic field generating unit,
, ≪ / RTI &
The magnetic body concentrates a nanoparticle containing drug introduced into the living body as it is magnetized by the magnetic field into a lesion in a region of the magnetic field,
Wherein,
Frequency, time and pattern of the magnetic field as the type of the magnetic field generated from the magnetic field generator,
Wherein when the plurality of magnetic field generating units are included, different types of magnetic fields generated from each of the plurality of magnetic field generating units are controlled differently. delete The method according to claim 1,
Wherein,
Wherein the type of magnetic field is controlled to concentrate the nanoparticles or conduct heat to the nanoparticles. The method of claim 3,
Wherein the control unit controls the frequency of the magnetic field to any one of 100 kHz to 300 kHz,
Wherein the magnetic substance is magnetized or demagnetized by a magnetic field having a frequency of 100 kHz to 300 kHz to generate heat to conduct heat to the nanoparticles. The method according to claim 1,
A sensor unit for measuring the number of nanoparticles concentrated in the affected part,
Further comprising:
Wherein,
Wherein the type of the magnetic field is changed from the first type to the second type according to whether or not the number of the nanoparticles concentrated in the lesion portion exceeds a preset reference. 6. The method of claim 5,
Wherein,
Controlling the type of the magnetic field to a frequency of 30 Hz or less as a first type to concentrate the nanoparticles,
And controlling the type of the magnetic field to a frequency between 100 kHz and 300 kHz as the second type when it is determined that the number of nanoparticles concentrated in the affected part exceeds a preset reference,
Wherein the magnetic material is magnetized or demagnetized by a magnetic field having a frequency of the second type to generate heat to conduct heat to the nanoparticle. The method according to claim 1,
Wherein,
Controlling the type of the magnetic field to a frequency of 30 Hz or less as a first type for a first predetermined time to concentrate the nanoparticles,
Controlling the type of the magnetic field to a frequency between 100 kHz and 300 kHz as a second type for a second predetermined time after the first time has elapsed,
Wherein the magnetic material is magnetized or demagnetized by a magnetic field having a frequency of the second type to generate heat to conduct heat to the nanoparticle. The method according to claim 1,
The magnetic body may include:
And is located in the magnetic field generating portion or is located at the affected portion by at least one of attachment, insertion and implantation. 9. The method of claim 8,
The magnetic body positioned in the magnetic field generating portion is,
A magnetic needle, and a spherical magnetic body that is coupled to an end of the magnetic needle. 10. The method of claim 9,
Wherein the magnetic field generating unit comprises:
A magnetic field core formed with a through hole; And
A coil wound around the magnetic core,
/ RTI >
And the magnetic material is positioned through the through-hole. 9. The method of claim 8,
Wherein the magnetic substance is a spherical magnetic substance. The method according to claim 1,
Wherein the control unit changes the frequency of the magnetic field at predetermined time intervals. delete The method according to claim 1,
Wherein the magnetic field generating unit comprises:
To generate a pulsed electro-magnetic field (PEMF). The method according to claim 1,
The magnetic field generator includes a first magnetic field generator, a second magnetic field generator, and a third magnetic field generator,
Wherein the first magnetic field generating portion, the second magnetic field generating portion, and the third magnetic field generating portion are arranged at a triangle so that magnetic field regions to be generated respectively cross each other. A computer-readable recording medium having recorded thereon a computer program for executing a method of driving a nanoparticle concentration apparatus for driving the nanoparticle concentration apparatus of claim 1. delete delete
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