CN210826167U - Gene screening is with detecting sample preservative fluid preprocessing device - Google Patents

Abstract

The utility model discloses a gene screening is with detection sample preservative solution preprocessing device, including the plastic bottle body, the lower surface both sides fixed mounting of plastic bottle body has the supporting legs, through screening case upper end fixed mounting in the gene there is locking spacing ring, be convenient for place the ladder face that is equipped with in plastic bottle body upper end inboard through locking spacing ring, can be with screening case spacing in the inside of plastic bottle body in the gene, lower extreme fixed mounting who screens the case in the gene has the prefilter net, be convenient for carry out the prefilter to the gene, there is the displacement spout of a set of relative setting at the inner wall below fixed mounting of plastic bottle body, be convenient for operate the slider and reciprocate in the displacement spout, can play spacing and guide effect to two layers of filter screen membranes simultaneously. The utility model discloses there is gene cell collection tray at the lower extreme fixed mounting of two layers of filtration nethike membranes, be convenient for store in introducing gene cell collection tray with the epithelial cells after filtering through two layers of filtration nethike membranes.

Description

Gene screening is with detecting sample preservative fluid preprocessing device

Technical Field

The utility model belongs to the technical field of gene screening preprocessing device, specifically be a gene screening is with detecting sample preservative solution preprocessing device.

Background

Cervical cancer is one of the most common malignant tumors in women, and is a disease which can be discovered and treated early and can be cured. TCT mainly used cervical cancer's screening, the process of domestic liquid-based cell film-making all is manual realization, and the settlement plate that uses, feed bin security are poor, need overturn and empty when cleaing away the interior liquid of feed bin, cross contamination easily, and the security is relatively poor.

The screening of the exfoliated cells comprises the following operations: sampling with a sampling brush, storing in a storage solution bottle, oscillating and dissolving uniformly, flaking and staining liquid-based thin-layer cells, and observing under a microscope. The flaking method mainly comprises manual flaking, including centrifugal sedimentation, membrane type flaking and the like, wherein the centrifugal sedimentation is the most used method for flaking exfoliated cells in the current medical detection institutions.

The cast-off cell preservation liquid bottle for flaking by the centrifugal sedimentation method at present has a single structure, a sampling brush is directly placed in a preservation liquid plastic bottle after sampling, liquid-based cells are eluted in the preservation liquid, impurities, mucus and the like are attached to a glass slide along with the cast-off cells, the quality of flaking is influenced, observation and analysis and judgment of a doctor are influenced, the structure of the existing preservation liquid plastic bottle needs to be improved, and better gene screening is facilitated.

SUMMERY OF THE UTILITY MODEL

For solving the problem that proposes among the above-mentioned background art, the utility model provides a gene screening is with detecting sample preservative fluid preprocessing device.

In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a gene screening is with detection sample preservative solution preprocessing device, includes the plastic bottle body, the lower surface both sides fixed mounting of plastic bottle body has the supporting legs, the screening case in the gene has been placed to the inside of plastic bottle body, the upper end fixed mounting of screening case in the gene has the locking spacing ring, the locking spacing ring is placed on the inboard ladder surface in plastic bottle body upper end, the lower extreme fixed mounting of screening case in the gene has the primary filter screen, the upper end threaded connection of plastic bottle body has the plastics bottle lid.

Preferably, the middle part threaded connection of plastics bottle lid has the straw, the lower extreme threaded connection of straw is in the middle part position of preliminary filter screen, the inner wall below fixed mounting of plastics bottle has the displacement spout of a set of relative setting.

Preferably, the lower extreme threaded connection of plastics bottle has the lifting screw, the lower extreme fixed mounting of lifting screw has rotatory hand dish, the upper end fixed mounting of lifting screw has the bearing, bearing fixed mounting is in the lower surface middle part position of gene cell collection dish.

Preferably, the last fixed surface of gene cell collection dish installs two layers of filtration nethike membranes, two sides fixed mounting of two layers of filtration nethike membranes has the operation slider, the inboard at the displacement spout of operation slider inlay card, fixed mounting has the observation panel in the cavity that the antetheca of plastic bottle opened.

Preferably, the observation panel and the two layers of filtering net films are arranged oppositely, and the two layers of filtering net films are trumpet-shaped.

Preferably, the both ends of displacement spout are logical groove structure, when the inside bottom of gene cell catch tray is pegged graft to the straw, the interval between two layers of filtration nethike embrane and the primary filter screen is 3-5 centimetres, two layers of filtration nethike embrane are network structure.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the utility model discloses in, through screening case upper end fixed mounting in the gene there is the locking spacing ring, be convenient for place the ladder face that is equipped with in plastic bottle body upper end inboard through the locking spacing ring, can be with screening the inside of case spacing at plastic bottle body in the gene, the lower extreme fixed mounting who screens the case in the gene has the prefilter screen, be convenient for carry out the prefilter screen to the gene, inner wall below fixed mounting at plastic bottle body has the displacement spout of a set of relative setting, be convenient for move the slider and reciprocate in the displacement spout, can play spacing and guide effect to two layers of filter net membranes simultaneously.

2. The utility model discloses in, lower extreme fixed mounting at two layers of filtration nethike embrane has gene cell catch tray, be convenient for introduce gene cell catch tray with epithelial cells after filtering through two layers of filtration nethike embrane and store, lower extreme threaded connection at the plastics bottle has lifting screw, lifting screw of being convenient for drives gene cell catch tray and two layers of filtration nethike embrane and reciprocates, middle part position threaded connection at plastics bottle lid and prefilter net has the straw, be convenient for can be with the cell suction in the gene cell catch tray through the straw, can carry out the preliminary treatment to the epithelial cell who takes out, be provided with the observation panel at the antetheca of plastics bottle, be convenient for better observation gene cell catch tray and the position that two layers of filtration nethike embranes removed, be convenient for the straw better with the thorough suction of epithelial cells in the gene cell catch tray.

The utility model discloses be convenient for better isolate epithelial cells, increase work efficiency, can take out the epithelial cells in the gene cell catch tray is whole simultaneously, be convenient for better carry out the preliminary treatment to epithelial cells.

Drawings

FIG. 1 is a sectional view of the structure of a pretreatment device for a preservation solution of a test sample for gene screening according to the present invention;

FIG. 2 is a front view of the structure of a pretreatment device for a preservation solution of a test sample for gene screening according to the present invention;

fig. 3 is an enlarged schematic view of the structure of the area a in fig. 1.

The labels in the figure are: 1 plastic bottle, 2 supporting legs, 3 in-gene screening boxes, 4 locking limiting rings, 5 primary filter screens, 6 plastic bottle caps, 7 straws, 8 displacement chutes, 9 lifting screws, 10 rotating hand discs, 11 bearings, 12 gene cell collecting discs, 13 two-layer filter net films, 14 running sliding blocks and 15 observation panels.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-3, a pretreatment device for a preservation solution of a test sample for gene screening, comprising a plastic bottle body 1, wherein supporting legs 2 are fixedly installed on two sides of the lower surface of the plastic bottle body 1, an intragenic screening box 3 is placed inside the plastic bottle body 1, a locking limiting ring 4 is fixedly installed at the upper end of the intragenic screening box 3, so that the intragenic screening box 3 can be limited inside the plastic bottle body 1 by placing the locking limiting ring 4 on a stepped surface arranged on the inner side of the upper end of the plastic bottle body 1, the locking limiting ring 4 is placed on the stepped surface on the inner side of the upper end of the plastic bottle body 1, a primary filter screen 5 is fixedly installed at the lower end of the intragenic screening box 3, so that the gene can be primarily screened, a plastic bottle cap 6 is connected with the upper end of the plastic bottle body 1 through a screw thread, a suction pipe 7 is connected with the middle part of, the taken-out epithelial cells can be pretreated, the lower end of a suction pipe 7 is in threaded connection with the middle position of a primary filter screen 5, a group of displacement chutes 8 which are oppositely arranged are fixedly arranged below the inner wall of a plastic bottle body 1, a sliding block 14 which is convenient to operate can move up and down in the displacement chutes 8, meanwhile, the limiting and guiding effects can be achieved on a secondary filter screen film 13, both ends of each displacement chute 8 are in a through groove structure, when the suction pipe 7 is inserted into the bottom end inside a gene cell collecting disc 12, the distance between the secondary filter screen film 13 and the primary filter screen 5 is 3-5 cm, the secondary filter screen film 13 is in a net structure, the lower end of the plastic bottle body 1 is in threaded connection with a lifting screw 9, the lifting screw 9 is convenient for driving the gene cell collecting disc 12 and the secondary filter screen film 13 to move up and down, a rotary hand disc 10 is fixedly arranged at the lower end of the, the bearing 11 is fixedly installed in the middle of the lower surface of the gene cell collecting tray 12, so that filtered epithelial cells can be conveniently introduced into the gene cell collecting tray 12 through the two layers of filtering net films 13 for storage, the two layers of filtering net films 13 are fixedly installed on the upper surface of the gene cell collecting tray 12, the two sides of the two layers of filtering net films 13 are fixedly installed with the operation sliders 14, the operation sliders 14 are clamped and embedded in the inner sides of the displacement chutes 8, the observation panel 15 is fixedly installed in a cavity formed in the front wall of the plastic bottle body 1, so that the movement positions of the gene cell collecting tray 12 and the two layers of filtering net films 13 can be better observed, a suction pipe 7 can better completely suck out the epithelial cells in the gene cell collecting tray 12, the observation panel 15 is opposite to the two layers of filtering net films 13, and the two layers of filtering net films 13 are horn-.

The working principle is as follows: when screening the gene, place locking spacing ring 4 on the inboard ladder face in 1 upper end of plastic bottle, pour the gene into in-gene screening case 3, the gene carries out prefilter through prefilter net 5, impurity and mucus are attached to prefilter net 5, remaining gene passes through prefilter net 5 landing on two layers of filtration nethike embrane 13, under two layers of filtration nethike embrane 13's effect, leave epithelial cell on two layers of filtration nethike embrane 13, epithelial cell landing stores in gene cell collection dish 12 simultaneously, remaining inflammatory cell, the erythrocyte, small-size histocyte, the bottom of landing to plastic bottle 1 through two layers of filtration nethike embrane 13.

After the filtration is finished, the plastic bottle cap 6 is in threaded connection with the upper end of the plastic bottle body 1, the suction pipe 7 is in threaded connection with the inner side of the plastic bottle cap 6, meanwhile, the lower end of the suction pipe 7 is in threaded connection with the middle position of the primary filter screen 5, the rotating hand disc 10 is rotated, the rotating hand disc 10 drives the lifting screw 9 to rotate, the gene cell collecting disc 12 and the two-layer filter net film 13 can be upwards pushed, the lower end of the suction pipe 7 is inserted into the gene cell collecting disc 12, an external pipeline is connected with the upper end of the suction pipe 7, epithelial cells in the gene cell collecting disc 12 can be sucked out, the lifting screw 9 drives the gene cell collecting disc 12 and the gene cell collecting disc 12 to move in position by rotating the rotating hand disc 10, epithelial cells at different depths in the gene cell collecting disc 12 can be sucked out, and the epithelial cells in the gene cell collecting disc 12 can be thoroughly sucked out, the residue is not easy to be generated.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (6)

1. The utility model provides a gene screening is with detection sample preservative solution preprocessing device, includes plastic bottle (1), its characterized in that, the lower surface both sides fixed mounting of plastic bottle (1) has supporting legs (2), screening case (3) in the gene has been placed to the inside of plastic bottle (1), the upper end fixed mounting of screening case (3) in the gene has locking spacing ring (4), place on the inboard ladder surface in plastic bottle (1) upper end in locking spacing ring (4), the lower extreme fixed mounting of screening case (3) in the gene has prefilter screen (5), the upper end threaded connection of plastic bottle (1) has plastic bottle lid (6).

2. The pretreatment device for the preservation solution of the test sample for gene screening according to claim 1, wherein a suction pipe (7) is connected to the middle of the plastic bottle cap (6) through a thread, the lower end of the suction pipe (7) is connected to the middle of the primary filter screen (5) through a thread, and a set of displacement chutes (8) which are arranged oppositely is fixedly arranged below the inner wall of the plastic bottle body (1).

3. The pretreatment device for the preservation solution of the test sample for gene screening according to claim 1, wherein the lower end of the plastic bottle body (1) is connected with a lifting screw (9) in a threaded manner, the lower end of the lifting screw (9) is fixedly provided with a rotating hand disc (10), the upper end of the lifting screw (9) is fixedly provided with a bearing (11), and the bearing (11) is fixedly arranged at the middle position of the lower surface of the gene cell collecting disc (12).

4. The pretreatment device for the preservation solution of the test sample for gene screening according to claim 3, wherein a second layer of filtering net film (13) is fixedly installed on the upper surface of the gene cell collecting tray (12), operation sliders (14) are fixedly installed on two sides of the second layer of filtering net film (13), the operation sliders (14) are clamped and embedded on the inner side of the displacement chute (8), and an observation panel (15) is fixedly installed in a cavity formed in the front wall of the plastic bottle body (1).

5. The pretreatment device for a test sample preservative fluid for gene screening according to claim 4, wherein the observation panel (15) is disposed opposite to the two-layer filter net (13), and the two-layer filter net (13) is formed in a horn shape.

6. The pretreatment device for the preservation solution of the test sample for gene screening according to claim 2, wherein both ends of the displacement chute (8) are both of a through groove structure, when the suction pipe (7) is inserted into the bottom end inside the gene cell collection tray (12), the distance between the two layers of filter net membranes (13) and the primary filter net (5) is 3-5 cm, and the two layers of filter net membranes (13) are of a net structure.

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