CN210746613U - Simulated weightlessness tail suspension experimental device - Google Patents
Simulated weightlessness tail suspension experimental device Download PDFInfo
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- CN210746613U CN210746613U CN201921292268.1U CN201921292268U CN210746613U CN 210746613 U CN210746613 U CN 210746613U CN 201921292268 U CN201921292268 U CN 201921292268U CN 210746613 U CN210746613 U CN 210746613U
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- tail suspension
- tail
- cross rod
- shell
- experimental
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- 239000000725 suspension Substances 0.000 title claims abstract description 162
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 238000010171 animal model Methods 0.000 claims abstract description 25
- 238000012544 monitoring process Methods 0.000 claims abstract description 16
- 230000005484 gravity Effects 0.000 claims abstract description 15
- 238000012806 monitoring device Methods 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 3
- 230000006855 networking Effects 0.000 claims description 6
- 229920006351 engineering plastic Polymers 0.000 claims description 3
- 239000010902 straw Substances 0.000 claims description 3
- 239000012780 transparent material Substances 0.000 claims description 3
- 238000002474 experimental method Methods 0.000 abstract description 6
- 238000004088 simulation Methods 0.000 abstract description 4
- 230000008859 change Effects 0.000 abstract description 2
- 238000012856 packing Methods 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 10
- 241000700159 Rattus Species 0.000 description 9
- 241000699666 Mus <mouse, genus> Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 210000003141 lower extremity Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- 241000581650 Ivesia Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 239000011505 plaster Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 230000003938 response to stress Effects 0.000 description 3
- 206010022998 Irritability Diseases 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000003194 forelimb Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- 208000001840 Dandruff Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 238000001035 drying Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
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Abstract
The utility model discloses an experimental apparatus is suspended in midair to simulation weightless tail suspends casing, tail in midair horizontal pole, gravity monitoring alarm device, feeds and eats device, monitoring device and packing box by the tail and constitutes. The tail suspension cross rod can move back and forth along the guide rail, and a tail suspension sliding block on the tail suspension cross rod can move left and right along the cross rod and is limited by a limiting sleeve and a limiting buckle. The lower part of the tail suspension sliding block is provided with a tail suspension hook for suspending a mouse; the water bottle is arranged on the side wall of the tail suspension shell through a water bottle hook; the lower part of the front side plate of the tail suspension shell is provided with a feeding port for fixing a feeding device and feeding; the gravity monitoring alarm device and the monitoring device monitor and send corresponding alarm information; the material pad box is arranged at the lower part of the tail suspension shell. The tail suspension experimental device has simple structure and can avoid the change of experimental state of experimental animals; the simulated weightlessness experiment environment is good.
Description
Technical Field
The utility model relates to an animal weightlessness research field under the simulation weightlessness environment, specifically speaking relates to a tail hanging device that is used for simulating mouse or rat experimental animals weightlessness research.
Background
People find that the physiology of astronauts changes when being different from the ground in the space weightless environment, and most of the astronauts are useless and harmful to the bodies. In order to better study the changes and find a method for alleviating and treating harmful changes, a simulated weightlessness experimental device needs to be manufactured on the ground, mice or other animals are used as human study objects to carry out a simulated weightlessness experiment, and corresponding medicines are developed to treat diseases caused by weightlessness.
Patent CN109512542A proposes "a suspension device and method", which is composed of a tail-bundling belt, a suspension rope and an inflation mechanism, and can be used for tail suspension experiments, and has little damage to the tail, but the inflation mechanism is not easy to control for a long time, if the device fails or the inflation bag explodes, the animal tail is easily damaged or even broken; and when the tail binding belt is bonded for a long time, the bonding part is easy to lose efficacy, and a tail hanging experiment is difficult to be continuously carried out for a long time.
Patent CN108542540A discloses a rat tail suspension device based on physical activity insufficiency, which comprises a net cover, a cage box, a linkage structure, a fixed structure and a bottom plate, and can enlarge the activity range of a rat and reduce the motion resistance; however, the device cannot control the range of motion of the rat, the hind limb of the rat may climb the side wall, which affects the effect of hind limb unloading, and the device cannot prevent the rat from spreading a large amount of feed on the lower floor, which causes the hind limb of the rat to step on the feed, which affects the tail suspension angle and effect.
Patent CN201905126U discloses a simulated weightlessness tail suspension device, which consists of a suspension body, an upper pull plate, a suspension cross rod, a suspension rope, a lower pull plate, a base and a hook; the device can ensure that the range of motion of the experimental animal is large, but the range of motion is not limited, so that the phenomenon that hind limbs climb the side wall is easy to occur, and the effect of tail suspension simulated weightlessness is influenced; the lower part of the device is not provided with a ventilation design, so that the air in the device is not easy to circulate and exchange with the outside; the feed is easy to spread at each corner of the device or spread on the lower bottom plate without a special feeding device, so that the phenomenon that the feed is stepped on by feet after the experimental animal is easy to occur, and the tail suspension simulation effect is influenced; and the feeding mode is abrupt, so that the experimental animal is easy to be frightened.
At present, a tail suspension device for simulating weightlessness is complex and imperfect, the motion range of a tail suspension experimental animal is small, so that the stress response of the experimental animal is large, or the motion range is too large, so that hind limbs of the experimental animal easily climb onto the side wall of the tail suspension device; the tail suspension device has poor air circulation, and the height of the tail suspension is inconvenient to adjust; in the experimental process, the bottom plate supporting the forelimb of the animal is not easy to replace and clean, and the stress reaction of the animal is larger when the bottom plate is replaced; the feeding mode also enables the animals to generate larger stress response, and a special feeding device is not provided, so that the situation that the hind limbs of the animals trample the feed is easy to occur.
SUMMERY OF THE UTILITY MODEL
In order to avoid the deficiencies in the prior art, the utility model provides a simulation weightless tail suspends experimental apparatus in midair.
The utility model adopts the technical proposal that the feeding device comprises an upper baffle, a tail suspension shell, a tail suspension cross rod, a tail suspension sliding block, a limit sleeve, a gravity monitoring alarm device, a tail suspension hook, a roller, a limit buckle, a water bottle hook, a water bottle, a straw, a feeding device, a monitoring device, a lower bottom plate and a material cushion box, and is characterized in that E-shaped guide rails are arranged on the upper parts of two side plates of the tail suspension shell, the upper baffle and the tail suspension cross rod are respectively positioned on the upper part and the lower part of the E-shaped guide rails, the tail suspension cross rod can move back and forth along the guide rails and is limited by the limit buckle in a groove on the lower part of the E-; the tail suspension sliding block is positioned on the tail suspension cross rod, can move axially along the tail suspension cross rod and is limited by a limiting sleeve on the tail suspension cross rod, the lower part of the tail suspension sliding block is connected with a tail suspension hook, and the gravity monitoring and alarming device is positioned on the tail suspension sliding block; the water bottle is arranged on a water bottle hook mounting hole on the side wall of the tail suspension shell through a water bottle hook; the lower part of the front side plate of the tail suspension shell is provided with a mounting opening for fixing the feeding device; the lower part of the side plate of the tail suspension shell is provided with a plurality of vent holes for exchanging air in the tail suspension device with the outside; the monitoring device is positioned in a groove of a side plate of the tail suspension shell, and a bottom plate replacing channel is arranged at the lower part of the tail suspension shell and used for replacing a lower bottom plate; the pad box is arranged at the lower part of the tail suspension shell through a C-shaped guide rail.
Two side plates of the tail suspension shell are made of transparent materials, the vent hole is positioned at the lower part of the tail suspension shell, scale marks for adjusting the tail suspension angle are marked on the side wall of the tail suspension shell, and the tail suspension angle is adjusted by adjusting a tail suspension chain for fixing a suspension object.
The two ends of the tail suspension cross rod are provided with rollers, so that the tail suspension cross rod can move on the E-shaped guide rail conveniently; and the limiting sleeve on the tail suspension cross rod is used for controlling the moving range of the tail suspension sliding block.
The gravity monitoring alarm device comprises a force sensor and a networking alarm instrument, and when the force measured by the force sensor is smaller than a certain value, the networking alarm instrument sends out corresponding alarm information.
The lower bottom plate is a fence-shaped frame plate consisting of a plurality of round rods, the diameter of each round rod is 10mm, and the distance between the round rods is 5 mm.
The pad box is made of engineering plastics and is in a drawer shape and used for collecting excrement of experimental animals.
Advantageous effects
The utility model provides a simulated weightlessness tail suspension experimental device, which is a tail suspension device for simulating the weightlessness research of experimental animals of mice or rats; the device is simple in structure, convenient and fast to operate and good in experimental environment.
Compared with the prior art, the method has the following characteristics:
1. the lower base plate is detached and replaced conveniently during experiments, the lower base plate can be extruded into the upper surface of the C-shaped guide rail through the lower base plate replacement channel, the used lower base plate is extruded out simultaneously, experimental animals do not need to be taken out, the experimental state of the experimental animals is reduced to the maximum extent, and the irritability of the experimental animals is reduced.
2. The tail suspends experimental apparatus in midair can make the animal all-round activity that the tail suspended in midair, and its home range can be adjusted to stop collar and spacing knot, has both reduced experimental animal's irritability, can avoid experimental animal home range uncontrollable again, and the condition that the lateral wall was climbed to the forelimb of still can be avoided experimental animal appears.
3. The lower part of the side wall of the tail suspension shell of the tail suspension experimental device is provided with the vent hole array, so that the exchange between the air in the experimental device and the outside can be increased, and the experimental animal breathes fresh air.
4. The tail suspension experimental device is provided with a special feeding device, and food can be fed into the feeding device from a feeding port on the side wall of the tail suspension shell, so that compared with the mode of directly feeding food from the upper part, the frightening effect on experimental animals can be reduced, and the stress response of the experimental animals can be reduced; and the feeding device special for storing food separates the food from the bottom plate, so that the situation that the food is scattered on the lower bottom plate and the hind limb of the experimental animal tramples the food is avoided.
5. The gravity monitoring and alarming device on the tail suspension sliding block can monitor whether the animal is separated from the suspension state or not, and when the animal is separated from the suspension state, the alarm is given, so that an operator can know the change of the experimental condition.
6. The monitoring device can enable an operator to remotely observe the state of the experimental animal in real time, and can observe whether the experimental animal falls to the ground or not to know the physical state of the experimental animal.
Drawings
The following describes the simulated weightlessness tail suspension experimental apparatus in detail with reference to the accompanying drawings and embodiments.
Fig. 1 is a schematic view of the simulated weightlessness tail suspension experimental device of the utility model.
Fig. 2 is a partially enlarged view of fig. 1.
Fig. 3(a) is an isometric view of the tail suspension housing of the present invention.
Fig. 3(b) is a schematic diagram of the position of the angle-adjusting scale mark of the tail suspension housing of the present invention.
Fig. 4 is a schematic view of the upper baffle of the present invention.
Fig. 5 is a schematic view of the tail suspension cross bar of the present invention.
Fig. 6(a) and (b) are schematic diagrams of the limit buckle and the limit sleeve of the present invention.
Fig. 7(a), (b) are perspective views of the feeding device of the present invention.
Fig. 8 is a schematic view of the lower plate of the present invention.
Fig. 9 is a schematic view of the pad box of the present invention.
Fig. 10(a) and (b) are schematic views of the water bottle and the water bottle hook of the present invention.
Fig. 11 is a schematic view of the monitoring device of the present invention.
In the drawings
1. The gravity monitoring and alarming device comprises an upper baffle 2, a tail suspension shell 3, a tail suspension cross rod 4, a tail suspension sliding block 5, a limiting sleeve 6, a gravity monitoring and alarming device 7, a tail suspension hook 8, a roller 9, a limiting buckle 10, a water bottle hook 11, a water bottle 12, a suction pipe 13, a feeding device 14, a monitoring device 15, a lower bottom plate 16, a cushion box 17, an E-shaped guide rail 18, a water bottle hook mounting hole 19, a mounting hole 20, a vent hole 21, a suction pipe mounting hole 22, a groove 23, a bottom plate replacement channel 24, a C-shaped guide rail 25 and tail suspension angle scale marks
Detailed Description
The embodiment is a simulated weightlessness tail suspension experimental device, which is used for simulating a mouse weightlessness experiment.
Referring to fig. 1 to 11, the simulated weightlessness tail suspension experimental apparatus in this embodiment is composed of an upper baffle 1, a tail suspension casing 2, a tail suspension cross rod 3, a tail suspension sliding block 4, a limiting sleeve 5, a gravity monitoring alarm device 6, a tail suspension hook 7, a roller 8, a limiting buckle 9, a water bottle hook 10, a water bottle 11, a straw 12, a feeding device 13, a monitoring device 14, a lower base plate 15 and a pad box 16. Wherein, the inner side of the upper part of the tail suspension shell is provided with an E-shaped guide rail 17, the upper half part of the E-shaped guide rail is provided with an upper baffle plate 1, and the lower half part is provided with a roller 8 and a limit buckle 9 which are connected with the tail suspension cross rod 3; the tail suspension sliding block 4 is sleeved on the tail suspension cross rod 3, the tail suspension sliding block 4 can axially move along the tail suspension cross rod 3 and is limited by the limiting sleeve 5 on the tail suspension cross rod, the lower part of the tail suspension sliding block 4 is provided with a tail suspension hook 7, and the gravity monitoring and alarming device 6 is installed on the tail suspension sliding block 4 and is connected with the tail suspension hook 7. A water bottle hook mounting hole 18 is formed in the middle of the front side plate of the tail suspension shell 2 and used for mounting a water bottle hook 10, a water bottle 11 is mounted in a matched mode with the water bottle hook 10, and a suction pipe 12 is arranged at the front end of the water bottle 11 and communicated with the interior of the tail suspension shell 2. A mounting opening 19 at the lower part of the front side plate of the tail suspension shell 2 is used for mounting the feeding device 13. Two side plates of the tail suspension shell 2 are made of transparent materials, and the lower part of the side plate of the tail suspension shell is provided with a groove 22 for installing the monitoring device 14; the lower part of the side plate of the tail suspension shell is provided with a plurality of vent holes 20 for exchanging the air in the tail suspension shell 2 with the outside. A bottom plate replacing channel 23 is arranged at the lower part of the tail suspension shell and used for replacing the lower bottom plate 15; a C-shaped guide rail 24 of the tail suspension housing is positioned below the bottom plate replacement channel 23, and the pad box 16 is mounted on the lower part of the tail suspension housing through the C-shaped guide rail 24. The pad box 16 is made of engineering plastics and is made into a drawer shape and used for collecting excrement of experimental animals. A reference scale line 25 for adjusting the tail suspension angle is marked above the side wall vent hole 20 of the tail suspension housing 2, and the tail suspension angle is adjusted by adjusting the tail suspension chain for fixing the mouse.
In this embodiment, the upper baffle 1 is a light high-strength transparent thin plate with fine holes, and is used to prevent external objects from falling into the tail suspension housing 2 and prevent mice or rats from escaping, and is convenient for air and outside circulation in the tail suspension housing 2. The lower bottom plate 15 is a fence-shaped frame plate structure consisting of a plurality of round rods, the diameter of each round rod is 10mm, and the distance between the round rods is 5 mm. The rollers at the two ends of the tail suspension cross rod are convenient for the tail suspension cross rod to move on the E-shaped guide rail; two limit sleeves on the tail suspension cross rod are used for controlling the moving range of the tail suspension sliding block. The gravity monitoring alarm device comprises a force sensor and a networking alarm instrument, and when the force measured by the force sensor is smaller than a certain value, the networking alarm instrument sends out corresponding alarm information.
The experimental operation process for simulating mouse weightlessness in the embodiment
1. Dipping medical paper into disinfecting alcohol to wipe grease, scurf and dirt on the surface of the mouse tail, wiping the tail with the medical paper or drying the tail in the air, and wiping the twisted copper wire;
2. cutting the medical adhesive plaster to a section of 7-8 cm, winding the medical adhesive plaster on the root of the mouse tail, and continuously winding the medical adhesive plaster and the copper wire to fix the root and the middle of the mouse tail and the copper wire together;
3. connecting a copper wire with a tail suspension hook and adjusting the suspension angle of the tail of the mouse to enable the body of the mouse to be parallel to a reference scale mark on a tail suspension shell, wherein the mouse is suspended at a tail of 30 degrees at a low position;
4. the position of the limiting buckle on the E-shaped guide rail is adjusted and fixed, the position of the limiting sleeve on the tail suspension cross rod is adjusted and fixed, and the movement of the tail suspension cross rod and the tail suspension sliding block is limited to control the mouse to move within a set moving range;
5. filling a proper amount of padding into the padding box, putting a proper amount of feed into the feeding device from a feeding port, putting a water bottle into a water bottle hook, and extending into the tail suspension shell through a suction pipe 12 at the front end of the water bottle 11;
6. opening a gravity monitoring alarm device and a monitoring device, and monitoring the conditions of the mouse tail suspension and the tail suspension shell in real time;
7. when the lower base plate needs to be replaced, the lower base plate can be extruded into the upper surface of the C-shaped guide rail through the base plate replacing channel, and the used lower base plate is extruded out.
Claims (6)
1. A simulated weightlessness tail suspension experimental device comprises an upper baffle, a tail suspension shell, a tail suspension cross rod, a tail suspension sliding block, a limiting sleeve, a gravity monitoring alarm device, a tail suspension hook, a roller, a limiting buckle, a water bottle hook, a water bottle, a straw, a feeding device, a monitoring device, a lower bottom plate and a material filling box, and is characterized in that E-shaped guide rails are arranged on the upper parts of two side plates of the tail suspension shell, the upper baffle and the tail suspension cross rod are respectively positioned on the upper part and the lower part of the E-shaped guide rails, the tail suspension cross rod can move back and forth along the guide rails and is limited by the limiting buckle in a groove on the lower part of the E; the tail suspension sliding block is positioned on the tail suspension cross rod, can move axially along the tail suspension cross rod and is limited by a limiting sleeve on the tail suspension cross rod, the lower part of the tail suspension sliding block is connected with a tail suspension hook, and the gravity monitoring and alarming device is positioned on the tail suspension sliding block; the water bottle is arranged on a water bottle hook mounting hole on the side wall of the tail suspension shell through a water bottle hook; the lower part of the front side plate of the tail suspension shell is provided with a mounting opening for fixing the feeding device; the lower part of the side plate of the tail suspension shell is provided with a plurality of vent holes for exchanging air in the tail suspension device with the outside; the monitoring device is positioned in a groove of a side plate of the tail suspension shell, and a bottom plate replacing channel is arranged at the lower part of the tail suspension shell and used for replacing a lower bottom plate; the pad box is arranged at the lower part of the tail suspension shell through a C-shaped guide rail.
2. The simulated weightlessness tail suspension experimental device according to claim 1, wherein two side plates of the tail suspension shell are made of transparent materials, the vent hole is positioned at the lower part of the tail suspension shell, the side wall of the tail suspension shell is marked with a scale mark for adjusting the tail suspension angle, and the tail suspension angle is adjusted by adjusting a tail suspension chain for fixing a suspension object.
3. The simulated weightlessness tail suspension experimental device according to claim 1, wherein rollers are arranged at two ends of the tail suspension cross rod to facilitate the tail suspension cross rod to move on the E-shaped guide rail; and the limiting sleeve on the tail suspension cross rod is used for controlling the moving range of the tail suspension sliding block.
4. The simulated weightlessness tail suspension experimental device according to claim 1, wherein the gravity monitoring alarm device comprises a force sensor and a networking alarm, and when the force measured by the force sensor is less than a certain value, the networking alarm sends out corresponding alarm information.
5. The simulated weightlessness tail suspension experimental device according to claim 1, wherein the lower bottom plate is a fence-shaped frame plate consisting of a plurality of round rods, the diameter of the round rods is 10mm, and the interval between the round rods is 5 mm.
6. The simulated weightlessness tail suspension experimental device according to claim 1, wherein the pad box is made of engineering plastics and is in a drawer shape for collecting the excrement of experimental animals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921292268.1U CN210746613U (en) | 2019-08-12 | 2019-08-12 | Simulated weightlessness tail suspension experimental device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921292268.1U CN210746613U (en) | 2019-08-12 | 2019-08-12 | Simulated weightlessness tail suspension experimental device |
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| CN210746613U true CN210746613U (en) | 2020-06-16 |
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| CN201921292268.1U Expired - Fee Related CN210746613U (en) | 2019-08-12 | 2019-08-12 | Simulated weightlessness tail suspension experimental device |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111713416A (en) * | 2020-07-10 | 2020-09-29 | 中国人民解放军63919部队 | Animal feeding cage suitable for biological rhythm wireless signal acquisition |
| CN112400718A (en) * | 2020-11-05 | 2021-02-26 | 天津大学 | Screw-nut type buckle structure and method for simulating weightless rat tail suspension |
| CN113170739A (en) * | 2021-06-01 | 2021-07-27 | 上海交通大学医学院附属第九人民医院 | Mouse feeding cage for simulating weightless environment |
| CN114868661A (en) * | 2022-03-24 | 2022-08-09 | 齐齐哈尔医学院 | Experimental animals behavior characteristic testing arrangement |
-
2019
- 2019-08-12 CN CN201921292268.1U patent/CN210746613U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111713416A (en) * | 2020-07-10 | 2020-09-29 | 中国人民解放军63919部队 | Animal feeding cage suitable for biological rhythm wireless signal acquisition |
| CN112400718A (en) * | 2020-11-05 | 2021-02-26 | 天津大学 | Screw-nut type buckle structure and method for simulating weightless rat tail suspension |
| CN113170739A (en) * | 2021-06-01 | 2021-07-27 | 上海交通大学医学院附属第九人民医院 | Mouse feeding cage for simulating weightless environment |
| CN114868661A (en) * | 2022-03-24 | 2022-08-09 | 齐齐哈尔医学院 | Experimental animals behavior characteristic testing arrangement |
| CN114868661B (en) * | 2022-03-24 | 2023-10-13 | 齐齐哈尔医学院 | Experimental animal behavior characteristic testing device |
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Granted publication date: 20200616 |