CN210367717U - Stirring device for producing kojic acid through biological fermentation - Google Patents
Stirring device for producing kojic acid through biological fermentation Download PDFInfo
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- CN210367717U CN210367717U CN201920936582.2U CN201920936582U CN210367717U CN 210367717 U CN210367717 U CN 210367717U CN 201920936582 U CN201920936582 U CN 201920936582U CN 210367717 U CN210367717 U CN 210367717U
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Abstract
The utility model discloses a stirring device for producing kojic acid by biological fermentation, which comprises a first reaction kettle and a second reaction kettle, wherein the first reaction kettle comprises a first kettle body, a multistage stirrer and a heating jacket; the second reaction kettle comprises a second kettle body, a second stirrer and an enzyme feed port. A first pipeline is arranged near the bottom of the first kettle body and connected to a feed inlet of the second kettle body, and a discharge outlet of the second kettle body is provided with a material supplementing port connected to the first kettle body through a second pipeline; the first pipeline and the second pipeline are respectively provided with a liquid driving device. The utility model provides a based on aspergillus fermentation agitating unit, the device mutually supports through two reation kettle, has solved the overheated problem that leads to fungus crowd and enzyme inactivation in bottom after fungus liquid fermentation a period, draws forth partly fungus liquid simultaneously, earlier with increase enzyme misce bene, flows back to the reaction system again, has improved the mixing efficiency of increase enzyme.
Description
Technical Field
The utility model relates to a microbial fermentation field and microbial production equipment field, specifically speaking relate to a agitating unit of biological fermentation production kojic acid.
Background
Kojic acid, chemical name of which is 5-hydroxy-2 hydroxymethyl-1, 4 pyrone, is easily soluble in solvents such as water, alcohol, chloroform and the like, and is mostly prepared by adopting a microbial fermentation method. Kojic acid has good application in the field of cosmetics, and has good effects on pigment precipitation, melanocyte improvement and the like.
Prior art fermentation of kojic acid with aspergillus (a), (b), (c), (dAspergillus) Mainly, aspergillus oryzae and aspergillus flavus are preferably used for fermentation under the conditions of certain carbon source, nitrogen source and nutrient factors. As kojic acid is in aerobic metabolism, continuous aeration and stirring are needed in the fermentation process, and the screening of aspergillus is the main means for improving the fermentation efficiency of the kojic acid at present, but the applicant finds that the reaction efficiency can be greatly improved by adding specific enzyme in the production process. However, if the enzyme solution is added by using a conventional fermentation tank, the enzyme solution and the homogenate are not uniformly mixed, and thus further improvement of the existing fermentation tank is required.
On the other hand, when the fermentation tank for producing kojic acid starts to react for 48 hours, the bottom temperature of the fermentation tank gradually rises, the average temperature is 2-3 ℃ higher than the upper layer temperature, and no method for effectively controlling the bottom reaction temperature is available at present.
SUMMERY OF THE UTILITY MODEL
The purpose of the invention is as follows: the utility model aims at providing a through external normal atmospheric temperature stirring and mix synergistic enzyme, rethread feed supplement mouth flows back to reation kettle's agitating unit.
The technical scheme is as follows: in order to achieve the purpose, the stirring device for producing kojic acid by biological fermentation comprises a first reaction kettle and a second reaction kettle, wherein the first reaction kettle comprises a first kettle body, a first stirrer arranged in the first kettle body and a heating jacket coated outside the first kettle body; the second reaction kettle comprises a second kettle body and a second stirrer arranged in the second kettle body; a first pipeline is arranged near the bottom of the first kettle body and connected to a feed inlet of the second kettle body, and a discharge outlet of the second kettle body is provided with a material supplementing port connected to the first kettle body through a second pipeline; the first pipeline and the second pipeline are respectively provided with a liquid driving device; the second kettle body is provided with an enzyme feed port.
The first stirrer comprises any one or combination of a vortex stirrer and a paddle stirrer. For reaction systems above 5T, a vortex stirrer is preferred.
In view of the thallus fermentation process of vortex agitator, bacterial liquid surface can be tensile big, adheres to in the internal wall of cauldron easily, the top of first agitator is equipped with the defoaming agitator. The defoaming agitator contacts the liquid level of fungus liquid when stirring, breaks up the flora that the surface distributes unevenly, makes the mixture more even based on the vortex agitator again.
In a preferred embodiment, the first stirrer is a defoaming stirrer and three vortex stirrers in sequence from top to bottom.
The second reaction kettle is used for auxiliary stirring and has the main functions of: 1) introducing high-temperature bacterial liquid at the bottom of the first reaction kettle, and stirring at normal temperature to properly reduce the temperature; 2) for adding the synergistic enzyme, part of the bacterial liquid is firstly utilized to be completely mixed with the synergistic enzyme and then flows back to the stirring system of the first reaction kettle, so that the mixing effect is better, and therefore, an anchor type stirrer is preferably used.
Liquid driving devices suitable for the fluid characteristics of the Aspergillus fermentation broth include, but are not limited to, screw pumps or gear pumps, preferably screw pumps.
Owing to introduce second reation kettle normal atmospheric temperature stirring, in order to realize the accurate control to the inside temperature of first reation kettle, as the utility model discloses a further optimization, the device still is equipped with a controller, locates the first temperature sensor of first cauldron body upper portion inner wall and locates the second temperature sensor of first cauldron body bottom, is equipped with the solenoid valve on first pipeline, the second pipeline respectively, the controller respectively with first temperature sensor, second temperature sensor and solenoid valve communication connection. The controller calculates the drainage quantity by receiving signals sent by the first temperature sensor and the second temperature sensor and combining the current reaction system and the temperature difference, and realizes the accurate control of the internal temperature by controlling the opening and closing of the electromagnetic valve.
Has the advantages that: the utility model provides a based on aspergillus fermentation agitating unit, the device mutually supports through two reation kettle, has solved the overheated problem that leads to fungus crowd and enzyme inactivation in bottom after fungus liquid fermentation a period, draws forth partly fungus liquid simultaneously, earlier with increase enzyme misce bene, flows back to the reaction system again, has improved the mixing efficiency of increase enzyme, can improve 12% yield through the experiment.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Detailed Description
The present invention will be further described with reference to the accompanying drawings.
Example 1
As shown in fig. 1, the stirring apparatus for producing kojic acid by biological fermentation of this embodiment includes first reaction kettle 1 and second reaction kettle 2, first reaction kettle 1 includes first kettle body 3, locate the first agitator in first kettle body 3, and the cladding is in heating jacket 5 outside first kettle body 3, first agitator from last down includes a defoaming agitator 6 and three vortex agitator 7 in proper order, the interval is the same between every agitator, first agitator is based on same main shaft 8, main shaft 8 is through the rotatory stirring of top motor drive. The second reaction kettle 2 comprises a second kettle body 4 and an anchor stirrer 10 arranged in the second kettle body 4.
A first pipeline 11 is arranged at the position, close to the bottom, of the first kettle body 3 and connected to a feed inlet of the second kettle body 4, and a discharge outlet of the second kettle body 4 is provided with a second pipeline 12 connected to a feed supplement port 13 of the first kettle body 3; the first pipeline 11 and the second pipeline 12 are respectively provided with a screw pump 14; an enzyme feeding port 15 is arranged above the second kettle body 4.
Example 2
As shown in fig. 1, this embodiment further includes a controller 16, a first temperature sensor 17 disposed on the inner wall of the upper portion of the first kettle 3, and a second temperature sensor 18 disposed at the bottom of the first kettle 3 based on embodiment 1. The first pipeline 11 and the second pipeline 12 are respectively provided with an electromagnetic valve, and the controller 16 is respectively connected with the first temperature sensor 17, the second temperature sensor 18 and the electromagnetic valve in a communication way. The controller 16 receives signals sent by the first temperature sensor 17 and the second temperature sensor 18, calculates the drainage quantity by combining the current reaction system and the temperature difference, and realizes accurate control of the internal temperature by controlling the opening and closing of the electromagnetic valve.
Claims (7)
1. The utility model provides a agitating unit of biological fermentation production kojic acid which characterized in that: the device comprises a first reaction kettle and a second reaction kettle, wherein the first reaction kettle comprises a first kettle body, a first stirrer arranged in the first kettle body and a heating jacket coated outside the first kettle body; the second reaction kettle comprises a second kettle body and a second stirrer arranged in the second kettle body;
a first pipeline is arranged near the bottom of the first kettle body and connected to a feed inlet of the second kettle body, and a discharge outlet of the second kettle body is provided with a material supplementing port connected to the first kettle body through a second pipeline; the first pipeline and the second pipeline are respectively provided with a liquid driving device; the second kettle body is provided with an enzyme feed port.
2. The stirring device for producing kojic acid by biological fermentation according to claim 1, wherein: the first stirrer comprises any one or combination of a vortex stirrer and a paddle stirrer.
3. The stirring device for producing kojic acid by biological fermentation according to claim 2, characterized in that: and a defoaming stirrer is arranged at the top of the first stirrer.
4. A stirring device for producing kojic acid by biological fermentation according to claim 3, characterized in that: the first stirrer is sequentially provided with a defoaming stirrer and three vortex stirrers from top to bottom.
5. The stirring device for producing kojic acid by biological fermentation according to claim 1, wherein: the second stirrer is an anchor stirrer.
6. The stirring device for producing kojic acid by biological fermentation according to claim 1, wherein: the liquid driving device is a screw pump or a gear pump.
7. The stirring device for producing kojic acid by biological fermentation according to claim 1, wherein: the device still is equipped with a controller, locates the first temperature sensor of first cauldron body upper portion inner wall and locates the second temperature sensor of first cauldron body bottom, is equipped with the solenoid valve on first pipeline, the second pipeline respectively, the controller respectively with first temperature sensor, second temperature sensor and solenoid valve communication connection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920936582.2U CN210367717U (en) | 2019-06-20 | 2019-06-20 | Stirring device for producing kojic acid through biological fermentation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920936582.2U CN210367717U (en) | 2019-06-20 | 2019-06-20 | Stirring device for producing kojic acid through biological fermentation |
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| CN210367717U true CN210367717U (en) | 2020-04-21 |
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| CN201920936582.2U Active CN210367717U (en) | 2019-06-20 | 2019-06-20 | Stirring device for producing kojic acid through biological fermentation |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113578229A (en) * | 2021-06-29 | 2021-11-02 | 浙江中科玖源新材料有限公司 | Polymerization reaction system capable of preventing violent heat release |
-
2019
- 2019-06-20 CN CN201920936582.2U patent/CN210367717U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113578229A (en) * | 2021-06-29 | 2021-11-02 | 浙江中科玖源新材料有限公司 | Polymerization reaction system capable of preventing violent heat release |
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Address after: 210000 building C, Shilin Industrial Park, No. 10, Wanshou Road, Jiangbei new area, Nanjing, Jiangsu Patentee after: Nanjing sbaike Biotechnology Co.,Ltd. Address before: 210000 floor 5, building C, Shilin Industrial Park, No. 10, Wanshou Road, Pukou District, Nanjing, Jiangsu Province Patentee before: SPEC-CHEM INDUSTRY Inc. |
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